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Pancreatic Carcinoma malady
4 drugs, 345 genes, 19 tissues, 1623 related diseases, 29 phenotypes, 406 articles, clinical trials.

Summaries for Pancreatic Carcinoma

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6Disease Ontology, 44Wikipedia, 22MalaCards
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Wikipedia: Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues forming...44 more...

MalaCards: Pancreatic Carcinoma, also known as carcinoma of pancreas (disorder), is related to lung carcinoma and carcinoma. An important gene associated with Pancreatic Carcinoma is SMAD4 (SMAD family member 4), and among its related pathways are PTEN Pathway and Cell adhesion_PLAU signaling. The drugs carmustine and diethylstilbestrol diphosphate and the compounds calcium and atp have been mentioned in the context of this disorder. Affiliated tissues include cells found in the tissues of the pancreas, bone marrow and lymph node, and related mouse phenotypes are nervous system and growth/size.

Disease Ontology: A pancreas cancer that is located in cells found in the tissues of the pancreas.6

Aliases & Descriptions for Pancreatic Carcinoma

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43UMLS, 6Disease Ontology, 7diseasecard, 32Novoseek , 33OMIM, 40SNOMED-CT, 27NCIt
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Aliases & Descriptions:

pancreatic carcinoma 6 7 32 43
carcinoma of pancreas (disorder) 6
exocrine pancreas carcinoma 6
carcinoma of pancreas 6
carcinoma 43

External Ids:

SNOMED-CT40 154475002, 372142002, 255089009 93938001, more
NCIt27 C3850

Related Diseases for Pancreatic Carcinoma

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13GeneCards, 14GeneDecks
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Diseases related to pancreatic carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1620)
idRelated DiseaseScoreTop Affiliating Genes
1lung carcinoma47.3PIK3CA, NCAM1, PCNA, RB1, SETD2, SERPINB5
2carcinoma47.2ZNF146, PIK3CA, NCAM1, RET, KITLG, KIF14
3pancreatitis47.2ZNF146, PIK3CA, NCAM1, RET, KITLG, KIF14
4squamous cell carcinoma43.5LGALS1, LGALS3, CD44, CDH1, MMP7, MKI67
5hepatocellular carcinoma43.3PIK3CA, NCAM1, RET, VTN, PCNA, RB1
6renal cell carcinoma41.9PIK3CA, RET, PCNA, GCNT2, SETD2, SERPINB2
7breast carcinoma41.2PIK3CA, KITLG, VTN, PCNA, RB1, RBBP8
8ovarian carcinoma39.7PIK3CA, VTN, PCNA, RB1, SETD2, SERPINB5
9non-small cell lung carcinoma39.2NCAM1, PCNA, RB1, SETD2, VEGFA, RASSF1
10basal cell carcinoma39.2BCL2, LGALS1, LGALS3, BAK1, BAX, JUP
11esophagitis39.0PIK3CA, NCAM1, RET, KITLG, PCNA, RB1
12endometrial carcinoma38.9PIK3CA, PCNA, RB1, SERPINB5, SERPINB2, VIM
13colon carcinoma38.9ZNF146, PIK3CA, NCAM1, KITLG, VTN, RBBP8
14papillary thyroid carcinoma38.7RET, SERPINB5, RARB, RASSF1, LGALS3, MUC4
15bladder carcinoma38.7PIK3CA, PCNA, RB1, SELE, SERPINB5, SERPINB2
16prostate carcinoma38.7BRCA2, VEGFA, CD82, CDH1, ITGA2, MMP9
17hepatitis38.5MGAT3, MGAT5, FASLG, FAS, IFNA1, IFNA2
18thyroiditis38.5PIK3CA, NCAM1, RET, KITLG, VTN, PCNA
19squamous cell carcinoma of the head and neck38.2PIK3CA, VTN, RB1, SETD2, VEGFA, VEGFB
20small cell carcinoma38.0NCAM1, PCNA, RB1, VIM, VIP, BRCA2
21cervicitis37.6PIK3CA, RET, KITLG, VTN, PCNA, RB1
22oral squamous cell carcinoma37.3PIK3CA, VTN, PCNA, RB1, SELE, SETD2
23neuroendocrine carcinoma37.1NCAM1, CHKA, CHGA, CEACAM5, CDH2, CDH1
24laryngeal squamous cell carcinoma37.1PCNA, RB1, VEGFA, BIRC5, CLU, BCL2
25adenoma36.9PIK3CA, NCAM1, RET, KITLG, PCNA, RB1
26adrenocortical carcinoma36.5NCAM1, KITLG, RB1, VIP, CHKA, CHGA
27esophageal squamous cell carcinoma36.2PIK3CA, NCAM1, PCNA, RB1, SELE, SETD2
28esophageal carcinoma36.1PCNA, RB1, SERPINB5, VEGFA, RARB, BIRC5
29liver cirrhosis36.1NCAM1, VTN, SERPINB2, VIP, RASSF1, LIF
30adenoid cystic carcinoma36.0NCAM1, PCNA, SERPINB5, VIM, RASSF1, LGALS3
31nasopharyngitis35.9PIK3CA, KITLG, PCNA, RB1, SETD2, SERPINB5
32ductal carcinoma in situ35.7PIK3CA, PCNA, RB1, VIM, BRCA2, VEGFA
33thyroid carcinoma35.7PIK3CA, RET, KITLG, PCNA, RB1, SELE
34clear cell renal cell carcinoma35.5SETD2, VIM, VEGFA, RASSF1, BIRC5, KDR
35cholangiocarcinoma35.4PIK3CA, NCAM1, PCNA, RB1, SELE, SERPINB5
36hepatitis b35.3CD274, IL10, IL12B, IL18, IFNA1, IFNA2
37pancreatic cancer35.3RET, SERPINB5, VIP, BRCA2, VEGFA, RAC1
38mucoepidermoid carcinoma35.2PCNA, CHGA, MUC4, MUC5AC, CEACAM5, CDKN1B
39gallbladder carcinoma35.0PIK3CA, NCAM1, PCNA, SERPINB5, VEGFA, RARB
40merkel cell carcinoma34.9NCAM1, KITLG, PCNA, VIM, RASSF1, BIRC5
41chromophobe renal cell carcinoma34.9PCNA, VIM, RARB, MET, MAGEA3, MAGEA4
42adenosquamous carcinoma34.6CHGA, MUC4, MUC5AC, CEACAM5, CEACAM7, FHIT
43cervical squamous cell carcinoma34.4RASSF1, BIRC5, BCL2, BAX, CEACAM5, CEACAM7
44colorectal adenoma and carcinoma34.4PCNA, VEGFA, BCL2, BAK1, BAX, CEACAM5
45lung adenocarcinoma34.2PIK3CA, RB1, SETD2, VEGFA, VEGFB, RARB
46papillary renal cell carcinoma34.0PCNA, VEGFA, RASSF1, KDR, CD44, MMP11
47laryngitis34.0PIK3CA, KIF14, PCNA, RB1, SETD2, SERPINB5
48large cell carcinoma33.9CHGA, CEACAM5, CEACAM7, CEACAM3, CDK4, ERBB2
49renal clear cell carcinoma33.9SETD2, VIM, VEGFA, RASSF1, BIRC5, KDR
50bile duct carcinoma33.9GCNT2, BCL2, MUC4, CDKN2A, CD44, CDH1

Graphical network of the top 20 diseases related to pancreatic carcinoma:



Graphical network of diseases related to pancreatic carcinoma

Clinical Features for Pancreatic Carcinoma

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Drugs & Therapeutics for Pancreatic Carcinoma

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for pancreatic carcinoma

Drug clinical trials:

Search ClinicalTrials for pancreatic carcinoma

Search NIH Clinical Center for pancreatic carcinoma

Search CenterWatch for pancreatic carcinoma

Inferred drug relations via UMLS/NDF-RT:

43 28 carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, nilutamide

Genetic Tests for Pancreatic Carcinoma

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Anatomical Context for Pancreatic Carcinoma

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11FMA, 22MalaCards
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MalaCards organs/tissues related to pancreatic carcinoma:

22
Bone marrow, Lymph node, Heart, Small intestine, Colon, Liver, Lung, Pancreas, Breast, Ovary, Prostate, Testis, Nk cells, T cells, B cells, Endothelial, Pancreatic islet, Pituitary

FMA organs/tissues related to pancreatic carcinoma:

11
Cells found in the tissues of the pancreas

Phenotypes for genes affiliated with Pancreatic Carcinoma

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25MGI
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MGI Mouse Phenotypes related to pancreatic carcinoma:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1nervous system phenotypeMP:000363114.2KITLG, RB1, VEGFB, RAPGEF3, RAC1, LIF
2growth/size phenotypeMP:000537813.0PIK3CA, RET, KITLG, RB1, SELE, SETD2
3embryogenesis phenotypeMP:000538013.0PIK3CA, RET, RBBP8, SETD2, SERPINB5, VIM
4homeostasis/metabolism phenotypeMP:000537612.4PIK3CA, RET, KITLG, VTN, GCNT2, RB1
5hematopoietic system phenotypeMP:000539712.3PCNA, GCNT2, SERPINB2, BRCA2, BID, BCL2
6normal phenotypeMP:000287311.9RET, VTN, SELE, VIP, BRCA2, VEGFA
7no phenotypic analysisMP:000301211.4RET, PCNA, RB1, VEGFA, ATM, CDKN1B
8integument phenotypeMP:001077111.3KITLG, GCNT2, RB1, BRCA2, RARG, RAC1
9craniofacial phenotypeMP:000538211.1KITLG, RARG, LAMA3, LAMP1, LAMP2, CFTR
10renal/urinary system phenotypeMP:000536711.0RET, GCNT2, RARB, CLU, BCL2, SCTR
11respiratory system phenotypeMP:000538810.9RET, LIF, BID, CFTR, IL12B, CALCA
12endocrine/exocrine gland phenotypeMP:000537910.9RET, BRCA2, RARG, CDKN1B, ITGA3, ARHGDIB
13immune system phenotypeMP:000538710.7GCNT2, SERPINB2, VIM, BRCA2, RARG, CLU
14limbs/digits/tail phenotypeMP:000537110.7RET, KITLG, RB1, BRCA2, VEGFA, RARB
15skeleton phenotypeMP:000539010.0KITLG, RB1, BRCA2, VEGFA, RARG, RARB
16liver/biliary system phenotypeMP:00053709.8VEGFA, LIF, BID, CHKA, CFTR, CD36
17other phenotypeMP:00053959.7RARG, RARB, CLU, KDR, CDKN2A, ITGA6
18hearing/vestibular/ear phenotypeMP:00053779.7KITLG, RB1, RARG, RARB, BCL2, BAK1
19reproductive system phenotypeMP:00053899.4PIK3CA, RET, VIP, BRCA2, VEGFA, RARG
20cardiovascular system phenotypeMP:00053859.4PIK3CA, RET, KITLG, RB1, SELE, SETD2
21muscle phenotypeMP:00053698.5PIK3CA, RET, RB1, SERPINB2, VIM, VEGFA
22adipose tissue phenotypeMP:00053758.4PIK3CA, RB1, LIF, BCL2, UBB, JDP2
23digestive/alimentary phenotypeMP:0005381INFRET, KITLG, RB1, BRCA2, VEGFA, RARG
24cellular phenotypeMP:0005384INFPIK3CA, NCAM1, RET, KITLG, PCNA, RB1
25vision/eye phenotypeMP:0005391INFPIK3CA, NCAM1, KITLG, RB1, SELE, VIM
26behavior/neurological phenotypeMP:0005386INFPIK3CA, NCAM1, GCNT2, RB1, SELE, VIM
27mortality/agingMP:0010768INFPIK3CA, NCAM1, RET, KITLG, RB1, RBBP8
28tumorigenesisMP:0002006INFPIK3CA, RET, KITLG, RB1, RBBP8, BRCA2
29pigmentation phenotypeMP:0001186INFKITLG, RB1, RAC1, BCL2, CDKN1B, CDKN2A

Publications for genes affiliated with Pancreatic Carcinoma

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35PubMed
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Articles related to pancreatic carcinoma:

(show top 50)    (show all 406)
idTitleAuthorsYearAffiliating Genes
1Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cells. (20484017)Batra S.... Srivastava S.K.2010CCND1, HDAC1, HDAC3
2Induced overexpression of protein kinase D1 stimulate s mitogenic signaling in human pancreatic carcinoma PANC-1 cells. (20082306)Kisfalvi K.... Rozengurt E.2010MAPK1, PKD1, PRKD1
3Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic carcinoma line resistant t o daunorubicin. (20335952)Borska S.... Dziegiel P.2010ABCB1
4Identification of liver metastasis-related genes in a novel human pancreatic carcinoma cell model by microarray analysis. (19375852)Shi W.D.... Liu L.M.2009MDM2, CDH1, MMP7
5EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells. (19804359)Camaj P.... Bruns C.J.2009EGFR, EFEMP1
6Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells. (19737400)Hage B.... Menke A.2009CDH1, RAC1, IQGAP1
7Consensus transcriptome signature of perineural invas ion in pancreatic carcinoma. (19509238)Abiatari I.... Kleeff J.2009ARHGDIB, KIF14
8Proliferation of colo-357 pancreatic carcinoma cells and survival of patients with pancreatic carcinoma are not altered by insulin glargine. (18316392)Erbel S.... Ritzel R.A.2008IGF1R
9Melatonin stimulates HSP27 phosphorylation in human pancreatic carcinoma cells (PANC-1). (17901593)Leja-Szpak A.... Pawlik W.W.2007HSPB1
10Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel quantitative model of metastasis in NOD/SCID/gammacnull (NOG) mice. (17786304)Suemizu H.... Nakamura M.2007S100A4
11RNA interference-mediated knockdown of DNMT1 and DNMT3B induces CXCL12 expression in MCF-7 breast cancer and AsPC1 pancreatic carcinoma cell lines. (17532557)Sowinska A.... Jagodzinski P.P.2007DNMT3B, DNMT1, CXCL12
12Anti-angiogenesis therapy in pancreatic carcinoma. (16525200)Saif M.W.2006VEGFA
13Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspirates. (17019794)Jhala N.... Grizzle W.E.2006CLU, MUC4, MSLN
14Activated Akt and Erk expression and survival after surgery in pancreatic carcinoma. (16788754)Chadha K.S.... Javle M.M.2006MAPK1
15Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. (15825074)Bachem M.G.... Adler G.2005TGFB1, FGF2
16Therapeutic synergism of gemcitabine and CpG-oligodeoxynucleotides in an orthotopic human pancreatic carcinoma xenograft. (16024642)Pratesi G.... Balsari A.2005TLR9
17Control of T-cell-mediated immune response by HLA class I in human pancreatic carcinoma. (15701833)Ryschich E.... Schmidt J.2005HLA-A
18Retroviral IFN-alpha gene transfer combined with gemcitabine acts synergistically via cell cycle alteration in human pancreatic carcinoma cells implanted orthotopically in nude mice. (15320962)Ziske C.... Schmidt-Wolf I.G.2004IFNA1
19Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis. (15526319)Ebrahimi B.... Kurzrock R.2004IL1RAPL2
20Expression of cancer testis antigens in pancreatic carcinoma cell lines, pancreatic adenocarcinoma and chronic pancreatitis. (14991579)Kubuschok B.... Pfreundschuh M.2004MAGEA4, MAGEA3, SYCP1
21Mechanisms of inhibition of growth of human pancreatic carcinoma implanted in nude mice by somatostatin receptor subtype 2 (15200918)Manoj K.... Qin R.Y.2004BCL2, SSTR2, BAX
22Pancreatic carcinoma cell lines with SMAD4 inactivation show distinct expression responses to TGFB1. (12619158)Jonson T.... HAPglund M.2003TGFB1
23Trypsinogen activation peptide (TAP) expression in ga llbladder bile identifies bilio-pancreatic carcinoma. (12820306)Brockmann J.G.... Senninger N.J.2003FLNB
24Characterization of the neoplastic phenotype in the familial atypical multiple-mole melanoma-pancreatic carcinoma syndrome. (12910525)Rulyak S.J.... Austin M.A.2003CDKN2A
25Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic control. (14670180)Fitzgerald M.... Domann F.E.2003SERPINB5, HIST2H3C
26Pancreatic carcinoma surveillance in patients with familial melanoma. (12925390)Parker J.F.... Leachman S.A.2003CDKN2A
27The recombinant anti-EGF receptor immunotoxin 425(scFv)-ETA' suppresses growth of a highly metastatic pancreatic carcinoma cell line. (12964002)Bruell D.... Barth S.2003EGFR
28Clinicopathological significance of hypoxia-inducible factor-1alpha expression in human pancreatic carcinoma. (14636255)Kitada T.... Wakasa K.2003HIF1A
29Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome. (11815963)Lynch H.T.... Kern S.2002CDKN2A
30Analysis of the cytochrome c-dependent apoptosis apparatus in cells from human pancreatic carcinoma. (11953820)Gerhard M.C.... HAocker G.2002CYCS
31Immunohistochemical expression of extracellular matrix proteins and adhesion molecules in pancreatic carcinoma. (11677955)Linder S.... Biberfeld P.2001ITGA4, ITGB1, ITGA6
32Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma. (11731440)Ueki T.... Goggins M.2001CCNG1
33Inhibition of caspase-1 induces cell death in pancreatic carcinoma cells and potentially modulates expression levels of bcl-2 family proteins. (11226429)Schlosser S.... Gansauge S.2001CASP1
34Therapy of human pancreatic carcinoma implants by irinotecan and the oral immunomodulator JBT 3002 is associated with enhanced expression of inducible nitric oxide synthase in tumor-infiltrating macrophages. (10646841)Bruns C.J.... Fidler I.J.2000NOS2
35Expression of the MMP-1 in human pancreatic carcinoma: relationship with prognostic factor. (10430270)Ito T.... Sekine I.1999MMP1
36Clinical usefulness of CA-19-9 in pancreatic carcinoma. (9671952)Nakao A.... Takagi H.1998CEACAM3
37Loss of tumorigenicity of human pancreatic carcinoma cells engineered to produce interleukin-2 or interleukin-4 in nude mice: a potentiality for cancer gene therapy. (9652792)Kimura M.... Sakiyama S.1998IL2, IL4
38Stromelysin 3 is overexpressed in human pancreatic carcinoma and regulated by retinoic acid in pancreatic carcinoma cell lines. (9824353)von Marschall Z.... Rosewicz S.1998MMP11
39Low serum levels of soluble CD44 variant 6 are significantly associated with poor prognosis in patients with pancreatic carcinoma. (9351541)Gansauge F.... Beger H.G.1997CD44
40Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma. (9020484)Cantero D.... BA1chler M.W.1997PLAU, PLAUR
41PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line. (8653710)Schaefer H.... Schmidt W.E.1996IER3
42Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice. (8971180)Reyes G.... CapellA! G.1996TP53, CDKN2A
43Granulocyte-colony stimulating factor produced by pancreatic carcinoma. (8723556)Uematsu T.... Mizuno R.1996CSF3
44Retinoids: effects on growth, differentiation, and nuclear receptor expression in human pancreatic carcinoma cell lines. (7557150)Rosewicz S.... Riecken E.O.1995CA2, RARG, CRABP2
45Chemopreventive activity of Oltipraz against N-nitrosobis(2-oxopropyl)amine (BOP)-induced ductal pancreatic carcinoma development and effects on survival of Syrian golden hamsters. (7554069)Clapper M.L.... Ruggeri B.A.1995TP53
46Immunohistochemical localization of group II phospholipase A2 in human pancreatic carcinomas. (8384235)Kiyohara H.... Ogawa M.1993PLA2G6
47Importance of E-selectin (ELAM-1) and sialyl Lewis(a) in the adhesion of pancreatic carcinoma cells to activated endothelium. (7687590)Iwai K.... Yoshiki T.1993SELE
48Hormonal therapy of pancreatic carcinoma. Rationale and perspectives. (8103783)Perilli D.... Celle G.1993EGF, SST, CCK
49Synergism between a novel amphibian oocyte ribonuclease and lovastatin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines. (1503903)Mikulski S.M.... Shogen K.1992HMGCR
50Epidermal growth factor and its receptors in human pancreatic carcinoma. (2343041)Chen Y.F.... Yanaihara N.1990EGF

Expression for genes affiliated with Pancreatic Carcinoma

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Pancreatic Carcinoma

Pathways for genes affiliated with Pancreatic Carcinoma

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36QIAGEN, 41Thomson Reuters, 20KEGG, 10EMD Millipore
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Pathways related to pancreatic carcinoma according to GeneDecks:

(show top 50)    (show all 344)
idPathwayScoreTop Affiliating Genes
1PTEN Pathway3612.0KITLG, VEGFB, RAC1, KDR, LAMA3, ITGA2
2Cell adhesion_PLAU signaling4111.8PIK3CA, VTN, SERPINB2, ITGB1, MET, GRB2
3Ras Pathway3611.4VEGFB, RALA, RALB, KDR, JUN, ITGA2
4Development_VEGF-family signaling4111.3PIK3CA, VTN, VEGFA, VEGFB, KDR, ITGB1
5Focal adhesion2011.3PIK3CA, VTN, VEGFB, RAC1, KDR, BCL2
6Pancreatic cancer2011.3BRCA2, RALA, RALB, AKT2
7Phospholipase-C Pathway3611.2KITLG, VEGFB, RALA, RAC1, RALB, KDR
8Signal transduction_PTEN pathway4111.2PCNA, ITGB1, IGF1R
9ErbB signaling pathway2011.1PIK3CA, JUN, CDKN1A, CDKN1B, GRB2, MAPK8
10Renal cell carcinoma2011.1RAC1, JUN, MET, GRB2, MAPK3, ETS1
11Development_GDNF family signaling4111.1PIK3CA, RET, ARTN, GRB2, MAPK3, MAPK10
12Telomerase Components in Cell Signaling3611.0KITLG, RB1, VEGFB, KDR, ATM, FLT1
13Mitochondrial Apoptosis3611.0KITLG, VEGFB, BID, KDR, BCL2, BCL2L1
14Rac1 Pathway3610.9KITLG, VEGFB, RAC1, KDR, JUN, ITGA2
15Germ Cell-Sertoli Cell Junction Dynamics3610.9RAC1, JUP, CDH2, ITGB1, IQGAP1, MAPK8
16Actin-Based Motility by Rho Family GTPases3610.8ITGA4, ITGA6, ITGB7, ARHGDIB, FGF7, IL2
17Development_HGF signaling pathway4110.8PIK3CA, RAC1, JUN, CDH1, FOS, MET
18Nuclear Receptor Activation by Vitamin-A3610.8KITLG, VEGFB, RARG, RARB, KDR, FLT1
19G1-S Phase Transition3610.7RB1, ATM, CDKN1A, CDKN1B, CDKN2A, CDK4
20Transcription P53 signaling pathway1010.6VEGFA, CDKN2A, MAPK8, MAPK10, TP53, HDAC1
21Development Prolactin receptor signaling1010.6PIK3CA, RAC1, BCL2, BCL2L1, JUN, GRB2
22UPA-UPAR Pathway3610.6VTN, LAMA3, JUN, ITGA2, ITGA3, ITGA4
23ERK5 Signaling3610.5KITLG, VEGFB, KDR, FOS, FOSL1, FLT1
24Rap1 Pathway3610.5KITLG, VEGFB, ITGA2, ITGA3, ITGA4, ITGA6
25IL-6 Pathway3610.4BAX, CD80, GRB2, IL10, IL11, IL12B
26mTOR Pathway3610.4KITLG, VEGFB, RAC1, FGF2, FGF7, IL2
27MAPK signaling pathway2010.4RAC1, JUN, FOS, FLNB, FGF2, FGF7
28Bladder cancer2010.3RB1, VEGFA, VEGFB, RASSF1, CDKN1A, CDKN2A
29Cell adhesion ECM remodeling1010.3VTN, LAMA3, CD44, ITGB1, MMP1, MMP2
30Cellular Apoptosis Pathway3610.1KITLG, VEGFB, BID, KDR, BCL2, BCL2L1
31ERK Signaling369.9KITLG, VEGFB, LAMA3, CD80, ITGA3, ITGA4
32Mucin expression in CF via TLRs, EGFR signaling pathways419.8MUC5AC, CFTR, JUN, FOS, FOSL1, GRB2
33PPAR Pathway369.6KITLG, VEGFB, ITGA2, ITGA3, ITGA4, ITGA6
34Endothelin-1 Signaling Pathway369.6CD80, FLT1, FGFR2, GRB2, IL10, IL11
35NF-KappaB (p50-p65) Pathway369.3KITLG, VEGFB, KDR, UBB, FLT1, FGF2
36Osteoclast differentiation209.3PIK3CA, RAC1, JUN, FOS, FOSL1, GRB2
37all-trans-Retinoic Acid Signaling in Brain368.7RARG, RARB, LIF, BCL2, BAX, CD80
38Measles208.7PIK3CA, CDKN1B, CDK4, IL12B, IL1B, IL2
39Antioxidant Action of Vitamin-C368.7KITLG, VEGFB, RAC1, LIF, KDR, BCL2
40Influenza A208.6PIK3CA, JUN, IL12B, IL18, IL1B, IL6
41MAPK Family Pathway368.5KITLG, VEGFB, RAC1, KDR, BCL2, BAX
42Malaria208.4SELE, CD36, MET, IL10, IL18, IL1B
43MIF Mediated Glucocorticoid Regulation368.4LIF, BCL2, BAX, CD80, IL10, IL11
44Transcription Role of VDR in regulation of genes involved in osteoporosis108.3JUN, FOS, FOSL1, IL1B, IL6, FASLG
45Tuberculosis208.2BID, BCL2, BAX, LAMP1, LAMP2, IL10
46Pertussis207.8JUN, ITGB1, FOS, IL10, IL12B, IL1B
47Immune response_MIF-mediated glucocorticoid regulation417.4JUN, MMP1, FOS, IL2, IL6, IL8
48Pathways in cancer20INFPIK3CA, RET, RB1, BRCA2, VEGFA, VEGFB
49Colorectal cancer20INFRAC1, FOS, MAPK8, MAP2K1, RHOA, TGFB1
50cAMP Pathway36INFKITLG, VEGFB, KDR, FLT1, FGF2, FGF7

Compounds for genes affiliated with Pancreatic Carcinoma

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Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
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Compounds related to pancreatic carcinoma according to GeneDecks:

(show top 50)    (show all 452)
idCompoundScoreTop Affiliating Genes
1calcium32 9 18 9 18.6KITLG, VTN, RB1, SERPINB2, VIP, RAPGEF3
2atp32 13.0PIK3CA, NCAM1, RET, VTN, RB1, SETD2
3glucose32 12.3SETD2, RAPGEF3, BID, SCT, LGALS1, BAK1
4hydrogen32 18 13.3SERPINB2, RAC1, SCT, CHGA, CEACAM3, CDK4
5gp 13032 11.9VIP, LIF, BCL2L1, IL18R1, FAS, MAPK3
6proline32 11.8SETD2, VIM, BRCA2, RAC1, CLU, LGALS3
7hematoxylin32 11.7NCAM1, PCNA, VIM, LGALS3, CHKA, CHGA
8hyaluronic acid32 18 12.6VTN, VIM, RAC1, CEACAM5, MSLN, CD36
9phosphotyrosine32 11.5PIK3CA, RET, RAC1, KDR, LGALS1, MUC5AC
10calcitriol32 42 9 18 9 15.4KITLG, RB1, RARB, LIF, CLU, BAK1
11fatty acid32 11.3CLU, LGALS3, CHKA, CDKN1B, CDKN2A, MKI67
1217-(allylamino)-17-demethoxygeldanamycin32 11.3SETD2, BIRC5, CDKN1A, CDK4, CDH1, ANXA5
13cholesterol32 9 18 9 14.2PIK3CA, KITLG, VTN, RB1, SELE, RAC1
1412-o-tetradecanoylphorbol 13-acetate32 11.2NCAM1, RET, RB1, SERPINB2, RARB, LIF
15nitric oxide32 9 18 9 14.1NCAM1, KITLG, RB1, SELE, SERPINB5, SERPINB2
16sp 60012532 42 12.0BID, CDKN1A, MMP1, FGF7, CASP3, TP53
17carbachol32 9 9 13.0SCT, CFTR, IL11, MAPK10, CCK, SST
18progestin32 11.0VIM, VEGFA, LIF, KDR, S100A6, CDK4
19daunorubicin32 9 9 12.9KITLG, BIRC5, BCL2, BCL2L1, MVP, BAX
202-methoxyestradiol32 18 11.9PCNA, SETD2, BID, BCL2, BCL2L1, BAX
21dihydrotestosterone32 9 18 9 13.8SETD2, VIM, VIP, CLU, CHKA, CDK4
22adriamycin32 10.8RB1, VIM, BRCA2, BIRC5, BCL2, BCL2L1
23folate32 10.7SELE, VIM, BRCA2, RASSF1, CLU, KDR
24adpribose32 10.7PIK3CA, PCNA, RB1, BRCA2, BID, BIRC5
25dmso32 10.7KITLG, VIM, CHGA, MUC5AC, LAMP1, CFTR
26cytarabine32 34 9 9 13.7KITLG, PCNA, RB1, VIM, LIF, BCL2
27valine32 10.6RET, VIM, VIP, RAC1, CFTR, CDKN2A
28sulindac32 9 9 12.6PCNA, BIRC5, BCL2, BCL2L1, BAX, CDKN1A
29polyethylene glycol32 10.5KITLG, VTN, SELE, VIP, CDH1, IGF2
30guanine32 9 18 9 13.5SELE, SETD2, VIP, RAPGEF3, RALA, RAC1
31tamoxifen32 34 9 9 13.5PIK3CA, VTN, PCNA, SELE, SERPINB5, VIM
32okadaic acid32 42 11.5PIK3CA, RB1, SERPINB2, VIM, BCL2, BCL2L1
33fludarabine32 9 9 12.4BID, BIRC5, BCL2, BCL2L1, BAK1, BAX
34arsenite32 18 11.4PIK3CA, PCNA, SETD2, VEGFA, RAC1, BIRC5
35thymidylate32 10.2PCNA, RB1, VIM, VEGFA, BIRC5, BCL2
36pd 16931632 10.2VEGFA, BCL2, MAPK8, MAPK14, MAPK1, MAP2K1
37ursodeoxycholic acid32 9 18 9 13.2PCNA, SCT, MKI67, CCK, IFNA1, IFNA2
38mannitol32 9 9 12.2SCT, CDKN3, CDH1, FGF2, MAPK8, MAPK3
39pd15303532 10.2VEGFA, BIRC5, JUN, MMP1, MAPK8, MAPK14
40ibmx32 9.9VIP, RARB, SCT, CFTR, CDKN3, MMP2
41u012632 42 10.7JUN, MMP1, IL6, IL8, MAPK8, MAPK14
42staurosporin32 9.7PIK3CA, BCL2, BCL2L1, JUN, CDKN3, IL8
43arachidonic acid32 9 18 9 12.5PIK3CA, NCAM1, KITLG, VIM, RAC1, LIF
44thymidine32 18 10.4PIK3CA, KITLG, PCNA, RB1, VIP, BRCA2
45cytochalasin d32 42 10.3KITLG, VTN, SELE, VIM, RAC1, CFTR
46tpck32 9.3BCL2L1, BAK1, JUN, IL1B, IL6, IL8
47lactacystin32 9.1SELE, BIRC5, BCL2, BCL2L1, JUN, CDKN1A
48ndga32 9.0JUN, FOS, IL1B, ANXA5, MAPK10, IGF1R
49anisomycin32 42 9 9 11.5JUN, FOS, IL1B, IL6, FASLG, FAS
50troglitazone32 42 9 9 10.6RB1, SELE, BIRC5, BCL2, BAK1, BAX

GO Terms for genes affiliated with Pancreatic Carcinoma

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12Gene Ontology
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Cellular components related to pancreatic carcinoma according to GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.5CTNNB1, SRPK1, SRC, CYCS, PTK2, PTHLH
2integral to plasma membraneGO:00588711.3ACVR1B, ABCC5, ABCC3, ABCC2, ABCC1, PDGFRB
3extracellular regionGO:00557611.2MMP7, IGF2, IGHG1, IGF1, IFNA2, IFNG
4cytoplasmGO:00573711.0SRPK1, CTNNB1, CTNND1, NR3C1, SMAD4, CRABP2
5platelet alpha granule lumenGO:03109310.9THBS1, TGFB1, TGFB2, TGFB3, EGF, PLG
6cell surfaceGO:00998610.6HSPB1, HSPD1, CAV1, TNF, PTPRT, PTPRJ
7membraneGO:01602010.4GDI2, GGT1, VEGFA, VEGFB, RAPGEF3, BID
8nucleoplasmGO:00565410.2RPS27A, SMAD4, NR3C1, PPARG, TERT, TERF2IP
9external side of plasma membraneGO:0098979.7FASLG, FAS, ENG, ANXA5, IFNG, ICAM1
10extracellular spaceGO:0056159.1KITLG, ARTN, FGF2, FGF7, MET, IL10
11cytosolGO:005829INFHMGA1, PLCB1, NOS2, RPS27A, NFKB1, NFKBIA
12plasma membraneGO:005886INFHRH4, PLAU, PLAUR, PLG, RPS27A, NFKBIA

Biological processes related to pancreatic carcinoma according to GeneDecks:

(show top 50)    (show all 73)
idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716512.2RET, KITLG, RARB, RAPGEF3, RALA, RALB
2epidermal growth factor receptor signaling pathwayGO:00717311.7PIK3CA, UBB, CDKN1B, GRB2, MDM2, MAPK3
3cell adhesionGO:00715511.4NCAM1, KITLG, VTN, RAC1, LGALS3BP, MUC5AC
4transforming growth factor beta receptor signaling pathwayGO:00717911.3UBB, JUN, FOS, ENG, TP53, SMAD4
5Ras protein signal transductionGO:00726511.3RB1, RALA, RASSF1, RALB, CDKN1A, CDKN2A
6nerve growth factor receptor signaling pathwayGO:04801111.3PIK3CA, RALA, RAC1, RALB, UBB, CDKN1B
7blood coagulationGO:00759611.3PIK3CA, SERPINB2, VEGFA, VEGFB, RAPGEF3, RAC1
8positive regulation of cell migrationGO:03033511.3RET, VEGFA, KDR, ITGB1, FLT1, MAP2K1
9virus-host interactionGO:01904811.3RB1, VIM, RALA, KDR, BAX, CD80
10positive regulation of cell proliferationGO:00828411.2VIP, VEGFA, LIF, BIRC5, KDR, BCL2L1
11negative regulation of cell growthGO:03030811.1RB1, BCL2, CDKN1A, CDKN1B, CDKN2A, ING1
12induction of apoptosis by intracellular signalsGO:00862910.9BID, CLU, BCL2, BCL2L1, BAK1, BAX
13platelet degranulationGO:00257610.9VEGFA, VEGFB, CLU, LAMP2, CD36, IGF1
14positive regulation of endothelial cell proliferationGO:00193810.9VEGFA, VEGFB, KDR, JUN, FGF2, NRP1
15platelet activationGO:03016810.9PIK3CA, VEGFA, VEGFB, RAPGEF3, RAC1, CLU
16cell cycle arrestGO:00705010.9RB1, RASSF1, ATM, CDKN1A, CDKN1B, CDKN2A
17positive regulation of cell divisionGO:05178110.8VEGFA, VEGFB, FGF2, FGF7, FGFR2, IL1B
18angiogenesisGO:00152510.8PIK3CA, SETD2, VEGFA, RAPGEF3, KDR, JUN
19vascular endothelial growth factor receptor signaling pathwayGO:04801010.8VEGFA, VEGFB, KDR, FLT1, MAPK14, NRP1
20cell-cell signalingGO:00726710.7CGB, CD80, CD97, FGFR2, GRAP2, GRB2
21release of cytochrome c from mitochondriaGO:00183610.7BID, CLU, BCL2, BCL2L1, BAK1, BAX
22induction of apoptosis by extracellular signalsGO:00862410.5RAC1, UBB, BAK1, BAX, FASLG, FAS
23positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.4KITLG, VTN, VEGFA, VEGFB, LIF, CD36
24activation of MAPK activityGO:00018710.4UBB, FGF2, MET, IL1B, MAPK3, MAPK14
25cellular component movementGO:00692810.3SERPINB5, VIM, RAC1, CD97, ARHGDIB, IL8
26toll-like receptor signaling pathwayGO:00222410.3UBB, JUN, FOS, MAPK8, MAPK3, MAPK14
27MyD88-dependent toll-like receptor signaling pathwayGO:00275510.2UBB, JUN, FOS, MAPK8, MAPK3, MAPK14
28Toll signaling pathwayGO:00806310.2UBB, JUN, FOS, MAPK8, MAPK3, MAPK14
29positive regulation of apoptotic processGO:04306510.1RARG, RARB, BID, CLU, BAK1, BAX
30response to radiationGO:00931410.1BCL2, JUN, CDC25A, MMP9, IL18, CCKAR
31toll-like receptor 4 signaling pathwayGO:03414210.1UBB, JUN, FOS, MAPK8, MAPK3, MAPK14
32response to estradiol stimulusGO:03235510.1BRCA2, BID, AURKA, MMP9, IL1B, CASP8
33innate immune responseGO:04508710.0CLU, BCL2, BCL2L1, LGALS3, UBB, JUN
34TRIF-dependent toll-like receptor signaling pathwayGO:0356669.9UBB, JUN, FOS, MAPK8, MAPK3, MAPK14
35positive regulation of MAP kinase activityGO:0434069.9KITLG, VEGFA, FLT1, GH1, ERBB2, TNF
36negative regulation of cell proliferationGO:0082859.8RARG, RARB, LIF, BAK1, JUN, CDKN1A
37anti-apoptosisGO:0069169.8PIK3CA, SERPINB2, VEGFB, BIRC5, BCL2, BCL2L1
38response to hypoxiaGO:0016669.8VEGFA, BCL2, ATM, MMP9, FLT1, IL18
39toll-like receptor 1 signaling pathwayGO:0341309.7UBB, JUN, FOS, MAPK8, MAPK3, MAPK14
40positive regulation of NF-kappaB transcription factor activityGO:0510929.5CLU, UBB, IL1B, IL6, ICAM1, TNF
41negative regulation of apoptotic processGO:0430669.5VEGFA, CLU, KDR, BCL2, BCL2L1, ATM
42positive regulation of peptidyl-serine phosphorylationGO:0331389.1PIK3CA, VEGFA, LIF, BCL2, CD44, MET
43response to drugGO:0424938.9BCL2, LGALS1, MVD, MVP, BAK1, JUN
44inflammatory responseGO:0069548.7SELE, RAC1, CD97, FOS, IL10, IL18
45positive regulation of transcription, DNA-dependentGO:0458938.1RET, RB1, BRCA2, JUN, CDKN2A, CD80
46positive regulation of transcription from RNA polymerase II promoterGO:0459447.9RB1, VEGFA, RARG, RARB, LIF, UBB
47induction of apoptosisGO:006917INFBAX, CDKN1B, CDKN2A, FASLG, FAS, MAPK1
48axon guidanceGO:007411INFNCAM1, RAC1, ITGA2, ITGB1, ARTN, MET
49positive regulation of ERK1 and ERK2 cascadeGO:070374INFVEGFB, KDR, CD44, FGF2, FGFR2, IL1B
50apoptotic processGO:006915INFVIM, RAC1, RALB, BID, BIRC5, BCL2

Molecular functions related to pancreatic carcinoma according to GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:00552411.2ABCC1, ABCC11, ABCC12, ABCC2, ABCC3, ABCB1
2protein heterodimerization activityGO:04698211.0HIF1A, EGFR, NR3C1, TP53, TLR6, TGFB1
3protein phosphatase bindingGO:01990310.3CSK, EGFR, CTNND1, CTNNB1, ERBB2, GRB2
4enzyme bindingGO:0198999.8PLAUR, PLCB1, NFKBIA, WWOX, EGFR, HIF1A
5protein homodimerization activityGO:0428039.7PLCB1, SMAD4, NR3C1, PTGS2, TERT, HMGCR
6growth factor activityGO:0080839.5IL9, IL6, IL4, IL2, IL1B, IL12B
7cytokine activityGO:0051258.3WNT2, IL10, FGF2, LIF, VEGFA, KITLG
8identical protein bindingGO:042802INFSLC2A1, , TGFB3, THBS1, EGFR, NFKBIA
9protein bindingGO:005515INFE2F5, E2F1, HDAC3, HDAC1, EFEMP1, RRM2

Sources for Pancreatic Carcinoma

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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