MCID: PNC073
MIFTS: 37

Pancreatic Carcinoma, Somatic malady

Endocrine diseases, Cancer diseases categories
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Summaries for Pancreatic Carcinoma, Somatic

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MalaCards based summary: Pancreatic Carcinoma, Somatic, also known as pancreatic cancer, somatic, is related to pancreatitis and pancreatic cancer, and has symptoms including An important gene associated with Pancreatic Carcinoma, Somatic is RBBP8 (retinoblastoma binding protein 8), and among its related pathways are BARD1 signaling events and BRCA1 Pathway. The compounds o6-methylguanine and oxaliplatin have been mentioned in the context of this disorder. Affiliated tissues include colon and breast, and related mouse phenotypes are respiratory system and liver/biliary system.

Description from OMIM:46 260350

Aliases & Classifications for Pancreatic Carcinoma, Somatic

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Pancreatic Carcinoma, Somatic, Aliases & Descriptions:

Name: Pancreatic Carcinoma, Somatic 46
 
Pancreatic Cancer, Somatic 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Related Diseases for Pancreatic Carcinoma, Somatic

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Diseases related to Pancreatic Carcinoma, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis30.5KRAS, SMAD4
2pancreatic cancer30.3SMAD4, KRAS
3malignant mixed mullerian tumor10.2KRAS, TP53
4gallbladder cancer10.2KRAS, TP53
5lynch syndrome10.2KRAS, TP53
6endometrial carcinoma10.2TP53, KRAS
7breast ductal carcinoma10.1SMAD4, TP53
8seminoma10.1SMAD4, KRAS
9pancreatitis, chronic10.1KRAS, SMAD4
10adrenocortical carcinoma10.1SMAD4, TP53
11esophageal cancer10.1SMAD4, TP53
12nasopharynx carcinoma10.1SMAD4, TP53
13testicular cancer10.0STK11, KRAS
14juvenile polyposis syndrome10.0STK11, SMAD4
15papilloma10.0TP53, STK11
16cowden disease10.0STK11, SMAD4
17gastric adenocarcinoma10.0KRAS, SMAD4
18cholangiocarcinoma10.0SMAD4, TP53, KRAS
19colon adenocarcinoma10.0SMAD4, KRAS
20stomach cancer9.9TP53, SMAD4, KRAS
21ataxia telangiectasia9.9STK11, TP53
22colonic benign neoplasm9.9TP53, SMAD4, KRAS
23ovarian cancer9.9KRAS, TP53, SMAD4
24non-small cell lung carcinoma9.9STK11, KRAS, TP53
25burkitt's lymphoma9.8SMAD4, KRAS, TP53
26rhabdomyosarcoma9.8SMAD4, TP53
27lung cancer9.8TP53, KRAS, STK11
28cervical cancer9.8STK11, SMAD4, TP53
29retinoblastoma9.8SMAD4, RBBP8, KRAS, TP53
30melanoma9.7STK11, KRAS, TP53
31familial adenomatous polyposis9.6STK11, KRAS, TP53, SMAD4
32lung benign neoplasm9.6STK11, SMAD4, KRAS, TP53
33lung adenocarcinoma9.6SMAD4, TP53, KRAS, STK11
34adenoma9.6SMAD4, STK11, KRAS, TP53
35breast cancer9.6STK11, KRAS, TP53, SMAD4
36liver cancer9.6KRAS, STK11, TP53, SMAD4
37colorectal cancer9.6SMAD4, TP53, STK11, KRAS
38tongue squamous cell carcinoma9.6KRAS, STK11, TP53, SMAD4
39adenocarcinoma9.6SMAD4, TP53, KRAS, STK11

Graphical network of the top 20 diseases related to Pancreatic Carcinoma, Somatic:



Diseases related to pancreatic carcinoma, somatic

Symptoms for Pancreatic Carcinoma, Somatic

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Symptoms by clinical synopsis from OMIM:

260350

Clinical features from OMIM:

260350

HPO human phenotypes related to Pancreatic Carcinoma, Somatic:

id Description Frequency HPO Source Accession
1 neoplasm of the pancreas HP:0002894

Drugs & Therapeutics for Pancreatic Carcinoma, Somatic

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Drug clinical trials:

Search ClinicalTrials for Pancreatic Carcinoma, Somatic

Search NIH Clinical Center for Pancreatic Carcinoma, Somatic

Genetic Tests for Pancreatic Carcinoma, Somatic

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Anatomical Context for Pancreatic Carcinoma, Somatic

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MalaCards organs/tissues related to Pancreatic Carcinoma, Somatic:

32
Colon, Breast

Animal Models for Pancreatic Carcinoma, Somatic or affiliated genes

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Publications for Pancreatic Carcinoma, Somatic

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Variations for Pancreatic Carcinoma, Somatic

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Clinvar genetic disease variations for Pancreatic Carcinoma, Somatic:

6 (show all 13)
id Gene Name Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.105G> T (p.Leu35Phe)single nucleotide variantPathogenicrs121912661GRCh37Chr 17, 7579582: 7579582
2KRASNM_033360.3(KRAS): c.35G> A (p.Gly12Asp)single nucleotide variantPathogenicrs121913529GRCh37Chr 12, 25398284: 25398284
3KRASNM_033360.3(KRAS): c.35G> T (p.Gly12Val)single nucleotide variantPathogenicrs121913529GRCh37Chr 12, 25398284: 25398284
4SMAD4NM_005359.5(SMAD4): c.1236C> G (p.Tyr412Ter)single nucleotide variantPathogenicrs121912577GRCh37Chr 18, 48593485: 48593485
5RBBP8NM_002894.2(RBBP8): c.1009A> G (p.Lys337Glu)single nucleotide variantPathogenicrs121434388GRCh37Chr 18, 20572799: 20572799
6STK11NM_000455.4(STK11): c.108C> A (p.Tyr36Ter)single nucleotide variantPathogenicrs137853079GRCh37Chr 19, 1207020: 1207020
7STK11NM_000455.4(STK11): c.650delC (p.Pro217Argfs)deletionPathogenicrs397518442GRCh37Chr 19, 1220632: 1220632
8STK11NM_000455.4(STK11): c.936delA (p.Lys312Asnfs)deletionPathogenicrs397518443GRCh37Chr 19, 1222999: 1222999
9ACVR1BNM_020328.3(ACVR1B): c.1282_1286delGATGA (p.Asp428Asnfs)deletionPathogenicrs387906389GRCh37Chr 12, 52380624: 52380628
10ACVR1BNM_020328.3: c.1385-502_1515+24del657deletionPathogenicGRCh37Chr 12, 52385145: 52385801
11SMAD4NM_005359.5(SMAD4): c.1072G> T (p.Gly358Ter)single nucleotide variantPathogenicrs121912576GRCh37Chr 18, 48591909: 48591909
12SMAD4NM_005359.5(SMAD4): c.1477G> C (p.Asp493His)single nucleotide variantPathogenicrs121912578GRCh37Chr 18, 48604655: 48604655
13SMAD4NM_005359.5(SMAD4): c.1543A> T (p.Arg515Ter)single nucleotide variantPathogenicrs121912579GRCh37Chr 18, 48604721: 48604721

Expression for genes affiliated with Pancreatic Carcinoma, Somatic

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Expression patterns in normal tissues for genes affiliated with Pancreatic Carcinoma, Somatic

Search GEO for disease gene expression data for Pancreatic Carcinoma, Somatic.

Pathways for genes affiliated with Pancreatic Carcinoma, Somatic

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Pathways related to Pancreatic Carcinoma, Somatic according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5RBBP8, TP53
2
Show member pathways
9.5RBBP8, TP53
3
Show member pathways
9.5TP53, KRAS
49.5KRAS, TP53
5
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
9.5TP53, KRAS
6
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.5KRAS, TP53
79.5TP53, KRAS
89.5KRAS, TP53
99.5KRAS, TP53
109.4KRAS, SMAD4
11
Show member pathways
9.3SMAD4, ACVR1B
12
Show member pathways
9.3SMAD4, ACVR1B
139.3TP53, SMAD4
14
Show member pathways
Cell cycle37
9.3TP53, SMAD4
159.3TP53, SMAD4
16
Show member pathways
Delta-Notch Signaling Pathway37
Notch Signaling Pathway37
9.3SMAD4, TP53
179.3SMAD4, TP53
189.3SMAD4, TP53
19
Show member pathways
9.2KRAS, STK11
209.1STK11, TP53
21
Show member pathways
9.0TP53, ACVR1B, KRAS
22
Show member pathways
MAPK signaling pathway37
9.0TP53, ACVR1B, KRAS
23
Show member pathways
9.0TP53, ACVR1B, KRAS
24
Show member pathways
8.9KRAS, ACVR1B, SMAD4
258.9KRAS, ACVR1B, SMAD4
268.9KRAS, TP53, SMAD4
27
Show member pathways
Signal transduction PTEN pathway60
8.9KRAS, TP53, SMAD4
288.9SMAD4, TP53, KRAS
29
Show member pathways
8.9SMAD4, TP53, KRAS
30
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.9SMAD4, TP53, KRAS
31
Show member pathways
8.8ACVR1B, TP53, SMAD4
328.7KRAS, STK11, TP53
33
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
8.6SMAD4, STK11, KRAS
348.5STK11, TP53, SMAD4
358.5STK11, TP53, SMAD4
368.1KRAS, STK11, TP53, SMAD4
378.1SMAD4, TP53, STK11, KRAS
38
Show member pathways
7.5KRAS, ACVR1B, STK11, TP53, SMAD4

Compounds for genes affiliated with Pancreatic Carcinoma, Somatic

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Compounds related to Pancreatic Carcinoma, Somatic according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1o6-methylguanine449.7TP53, KRAS
2oxaliplatin44 50 1111.6KRAS, TP53
3irinotecan44 50 1111.6KRAS, TP53
4leptomycin b44 6110.5TP53, SMAD4
55-methylcytosine44 2410.3STK11, TP53
6mg 13244 6110.3TP53, SMAD4
7crcs449.1KRAS, TP53, SMAD4
8oligonucleotide448.9SMAD4, TP53, KRAS
9threonine448.4ACVR1B, STK11, SMAD4
10paraffin448.3KRAS, STK11, TP53, SMAD4
11vegf448.3KRAS, STK11, TP53, SMAD4
12alanine448.2ACVR1B, STK11, SMAD4
13serine447.8SMAD4, TP53, STK11, ACVR1B, KRAS

GO Terms for genes affiliated with Pancreatic Carcinoma, Somatic

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Biological processes related to Pancreatic Carcinoma, Somatic according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1Ras protein signal transductionGO:0072659.6KRAS, TP53
2positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.6ACVR1B, SMAD4
3G1/S transition of mitotic cell cycleGO:0000829.5RBBP8, ACVR1B
4central nervous system developmentGO:0074179.5ACVR1B, TP53
5intrinsic apoptotic signaling pathway by p53 class mediatorGO:0723329.4TP53, STK11
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.3STK11, TP53
7transforming growth factor beta receptor signaling pathwayGO:0071799.3SMAD4, TP53
8positive regulation of transforming growth factor beta receptor signaling pathwayGO:0305119.3SMAD4, STK11
9negative regulation of transcription from RNA polymerase II promoterGO:0001229.1SMAD4, TP53, RBBP8
10in utero embryonic developmentGO:0017019.1ACVR1B, TP53, SMAD4
11cell cycle arrestGO:0070509.0STK11, TP53
12positive regulation of transcription from RNA polymerase II promoterGO:0459448.9ACVR1B, TP53, SMAD4
13insulin receptor signaling pathwayGO:0082868.9KRAS, STK11
14negative regulation of cell proliferationGO:0082858.7SMAD4, TP53, STK11
15negative regulation of cell growthGO:0303088.3ACVR1B, STK11, TP53, SMAD4

Molecular functions related to Pancreatic Carcinoma, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1LRR domain bindingGO:0302759.3KRAS, STK11
2damaged DNA bindingGO:0036849.2RBBP8, TP53
3RNA polymerase II transcription factor bindingGO:0010859.2TP53, SMAD4
4p53 bindingGO:0020399.1STK11, TP53
5protein bindingGO:0055157.1SMAD4, TP53, STK11, ACVR1B, KRAS, RBBP8

Products for genes affiliated with Pancreatic Carcinoma, Somatic

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  • Antibodies
  • Proteins
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Sources for Pancreatic Carcinoma, Somatic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet