MCID: PNC073
MIFTS: 31

Pancreatic Carcinoma, Somatic malady

Endocrine diseases, Cancer diseases categories

Summaries for Pancreatic Carcinoma, Somatic

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Sources:
48OMIM, 34MalaCards
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MalaCards: Pancreatic Carcinoma, Somatic, also known as malignant neoplasm of pancreas, is related to pancreatitis and pancreatic cancer. An important gene associated with Pancreatic Carcinoma, Somatic is RBBP8 (retinoblastoma binding protein 8), and among its related pathways are Endometrial cancer and TGF-beta Signaling Pathways. The compounds crcs and serine have been mentioned in the context of this disorder. Affiliated tissues include colon, pancreas and breast, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Description from OMIM:48 260350

Aliases & Classifications for Pancreatic Carcinoma, Somatic

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Sources:
48OMIM, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreatic carcinoma, somatic 48
malignant neoplasm of pancreas 63
pancreatic cancer, somatic 48


Related Diseases for Pancreatic Carcinoma, Somatic

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of diseases related to Pancreatic Carcinoma, Somatic:



Diseases related to pancreatic carcinoma, somatic

Symptoms for Pancreatic Carcinoma, Somatic

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48OMIM
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Symptoms by clinical synopsis from OMIM:

260350

Clinical features from OMIM:

260350

Drugs & Therapeutics for Pancreatic Carcinoma, Somatic

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Pancreatic Carcinoma, Somatic

Drug clinical trials:

Search ClinicalTrials for Pancreatic Carcinoma, Somatic

Search NIH Clinical Center for Pancreatic Carcinoma, Somatic

Search CenterWatch for Pancreatic Carcinoma, Somatic

Genetic Tests for Pancreatic Carcinoma, Somatic

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Anatomical Context for Pancreatic Carcinoma, Somatic

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Sources:
34MalaCards
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MalaCards organs/tissues related to Pancreatic Carcinoma, Somatic:

34
Colon, Pancreas, Breast

Animal Models for Pancreatic Carcinoma, Somatic or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Pancreatic Carcinoma, Somatic:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0SMAD4, KRAS, RBBP8
2MP:00053818.6KRAS, ACVR1B, SMAD4
3MP:00053798.5KRAS, ACVR1B, SMAD4
4MP:00053898.5KRAS, ACVR1B, SMAD4
5MP:00107718.4SMAD4, ACVR1B, KRAS
6MP:00028738.2KRAS, ACVR1B, SMAD4
7MP:00053808.2RBBP8, KRAS, ACVR1B, SMAD4
8MP:00053848.2RBBP8, KRAS, ACVR1B, SMAD4
9MP:00107688.1SMAD4, ACVR1B, KRAS, RBBP8

Publications for Pancreatic Carcinoma, Somatic

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Variations for Pancreatic Carcinoma, Somatic

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Sources:
1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Pancreatic Carcinoma, Somatic:

1 (show all 13)
id Gene Name Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.105G> T (p.Leu35Phe)single nucleotide variantPathogenicrs121912661GRCh37Chr 17, 7579582: 7579582
2KRASNM_033360.3(KRAS): c.35G> A (p.Gly12Asp)single nucleotide variantPathogenic, drug responsers121913529GRCh37Chr 12, 25398284: 25398284
3KRASNM_033360.3(KRAS): c.35G> T (p.Gly12Val)single nucleotide variantPathogenic, drug responsers121913529GRCh37Chr 12, 25398284: 25398284
4SMAD4NM_005359.5(SMAD4): c.1236C> G (p.Tyr412Ter)single nucleotide variantPathogenicrs121912577GRCh37Chr 18, 48593485: 48593485
5RBBP8NM_002894.2(RBBP8): c.1009A> G (p.Lys337Glu)single nucleotide variantPathogenicrs121434388GRCh37Chr 18, 20572799: 20572799
6STK11NM_000455.4(STK11): c.108C> A (p.Tyr36Ter)single nucleotide variantPathogenicrs137853079GRCh37Chr 19, 1207020: 1207020
7STK11NM_000455.4(STK11): c.650delC (p.Pro217Argfs)deletionPathogenicrs397518442GRCh37Chr 19, 1220632: 1220632
8STK11NM_000455.4(STK11): c.936delA (p.Lys312Asnfs)deletionPathogenicrs397518443GRCh37Chr 19, 1222999: 1222999
9ACVR1BNM_020328.3(ACVR1B): c.1282_1286delGATGA (p.Asp428Asnfs)deletionPathogenicrs387906389GRCh37Chr 12, 52380624: 52380628
10ACVR1BNM_020328.3: c.1385-502_1515+24del657deletionPathogenicGRCh37Chr 12, 52385145: 52385801
11SMAD4NM_005359.5(SMAD4): c.1072G> T (p.Gly358Ter)single nucleotide variantPathogenicrs121912576GRCh37Chr 18, 48591909: 48591909
12SMAD4NM_005359.5(SMAD4): c.1477G> C (p.Asp493His)single nucleotide variantPathogenicrs121912578GRCh37Chr 18, 48604655: 48604655
13SMAD4NM_005359.5(SMAD4): c.1543A> T (p.Arg515Ter)single nucleotide variantPathogenicrs121912579GRCh37Chr 18, 48604721: 48604721

Expression for genes affiliated with Pancreatic Carcinoma, Somatic

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Carcinoma, Somatic

Search GEO for disease gene expression data for Pancreatic Carcinoma, Somatic.

Pathways for genes affiliated with Pancreatic Carcinoma, Somatic

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Sources:
51PathCards, 31KEGG, 61Thomson Reuters, 55R&D Systems, 39NCBI BioSystems Database, 56Reactome, 13EMD Millipore, 58SinoBiological, 62Tocris Bioscience, 54QIAGEN
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Pathways related to Pancreatic Carcinoma, Somatic according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signal transduction PTEN pathway61
9.3SMAD4, KRAS
29.3SMAD4, KRAS
3
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.3SMAD4, KRAS
4
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
9.3KRAS, SMAD4
59.3KRAS, SMAD4
6
Show member pathways
9.3KRAS, SMAD4
79.3KRAS, SMAD4
89.3KRAS, SMAD4
99.3KRAS, SMAD4
10
Show member pathways
9.1SMAD4, ACVR1B
11
Show member pathways
9.1ACVR1B, SMAD4
12
Show member pathways
9.1ACVR1B, SMAD4
13
Show member pathways
9.1ACVR1B, SMAD4
14
Show member pathways
MAPK signaling pathway39
9.0KRAS, ACVR1B
15
Show member pathways
9.0ACVR1B, KRAS
16
Show member pathways
9.0KRAS, ACVR1B
17
Show member pathways
8.5SMAD4, ACVR1B, KRAS
18
Show member pathways
8.5SMAD4, ACVR1B, KRAS
198.5KRAS, ACVR1B, SMAD4

Compounds for genes affiliated with Pancreatic Carcinoma, Somatic

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Sources:
46Novoseek
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Compounds related to Pancreatic Carcinoma, Somatic according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1crcs469.0KRAS, SMAD4
2serine468.5KRAS, ACVR1B, SMAD4

GO Terms for genes affiliated with Pancreatic Carcinoma, Somatic

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Sources:
17Gene Ontology
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Biological processes related to Pancreatic Carcinoma, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axon guidanceGO:0074119.3KRAS, SMAD4
2positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.2ACVR1B, SMAD4
3negative regulation of cell growthGO:0303089.1ACVR1B, SMAD4
4G1/S transition of mitotic cell cycleGO:0000829.0ACVR1B, RBBP8
5in utero embryonic developmentGO:0017018.8ACVR1B, SMAD4

Molecular functions related to Pancreatic Carcinoma, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.0RBBP8, KRAS, ACVR1B, SMAD4

Products for genes affiliated with Pancreatic Carcinoma, Somatic

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pancreatic Carcinoma, Somatic

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet