MCID: PNC041
MIFTS: 38

Pancreatic Ductal Adenocarcinoma malady

Endocrine diseases category

Summaries for Pancreatic Ductal Adenocarcinoma

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32MalaCards
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MalaCards: Pancreatic Ductal Adenocarcinoma, also known as ductal adenocarcinoma of the pancreas, is related to adenocarcinoma and pancreatitis. An important gene associated with Pancreatic Ductal Adenocarcinoma is SAGE1 (sarcoma antigen 1), and among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR. Affiliated tissues include pancreas, lymph node and liver.

Aliases & Classifications for Pancreatic Ductal Adenocarcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreatic ductal adenocarcinoma 8 10 60
ductal adenocarcinoma of the pancreas 8


External Ids:

Disease Ontology8 DOID:3498
NCIt39 C9120

Related Diseases for Pancreatic Ductal Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Pancreatic Ductal Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.3SMAD4, MSLN, SERPINB5
2pancreatitis32.3SMAD4
3pancreatic cancer31.3MSLN, SERPINB5, SMAD4
4pancreas adenocarcinoma10.9
5mucinous adenocarcinoma10.8
6papillary adenocarcinoma10.7
7pancreatic intraductal papillary-mucinous neoplasm10.7
8pancreatic ductal carcinoma10.6
9adenocarcinoma in situ10.5
10papillary carcinoma10.4
11duodenitis10.4
12gastric adenocarcinoma10.4
13cystadenoma10.3
14alcoholic pancreatitis10.3
15pancreatic invasive intraductal papillary-mucinous carcinoma10.3
16pancreatic foamy gland adenocarcinoma10.3
17cholangiocarcinoma10.3
18hepatitis10.3
19pancreatic cystadenoma10.3
20stomatitis10.3
21renal clear cell carcinoma10.3
22clear cell adenocarcinoma10.3
23mucinous cystadenocarcinoma10.3
24acinar cell carcinoma10.3
25cystadenocarcinoma10.3
26renal cell carcinoma10.3
27cystic fibrosis10.2
28pancreatic mucinous cystadenoma10.2
29smooth muscle tumor10.2
30adenosquamous pancreas carcinoma10.2
31pancreatic acinar cell adenocarcinoma10.2
32ovarian mucinous adenocarcinoma10.2
33gastric papillary adenocarcinoma10.2
34hepatitis b10.2
35pancreatic serous cystadenoma10.2
36adenosquamous carcinoma10.2
37hepatitis a10.2
38breast adenocarcinoma10.2
39breast cancer10.2
40colon adenocarcinoma10.2
41diabetes mellitus10.2
42gastric diffuse adenocarcinoma10.2
43melanoma10.2
44neuroendocrine tumor10.2
45ovarian mucinous neoplasm10.2
46hereditary diffuse gastric cancer10.2
47pancreatitis, chronic10.0SERPINB5, SMAD4, MSLN
48stomach cancer10.0SERPINB5, SMAD4
49prostate cancer10.0SMAD4, SERPINB5
50cervical cancer10.0SMAD4

Graphical network of the top 20 diseases related to Pancreatic Ductal Adenocarcinoma:



Diseases related to pancreatic ductal adenocarcinoma

Clinical Features for Pancreatic Ductal Adenocarcinoma

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Drugs & Therapeutics for Pancreatic Ductal Adenocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pancreatic Ductal Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Pancreatic Ductal Adenocarcinoma

Search NIH Clinical Center for Pancreatic Ductal Adenocarcinoma

Search CenterWatch for Pancreatic Ductal Adenocarcinoma

Genetic Tests for Pancreatic Ductal Adenocarcinoma

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Anatomical Context for Pancreatic Ductal Adenocarcinoma

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Pancreatic Ductal Adenocarcinoma:

32
Pancreas, Lymph node, Liver, T cells, Endothelial, Skeletal muscle, Colon, Smooth muscle, Breast, Testes, Monocytes

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Pancreatic Ductal Adenocarcinoma:
id TissueAnatomical CompartmentCell Relevance
1 PancreasPancreatic Ducts  Affected by disease

Animal Models for Pancreatic Ductal Adenocarcinoma or affiliated genes

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Publications for Pancreatic Ductal Adenocarcinoma

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50PubMed
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Articles related to Pancreatic Ductal Adenocarcinoma:

(show top 50)    (show all 615)
idTitleAuthorsYear
1
Pancreatic ductal adenocarcinoma radiology reporting template: consensus statement of the society of abdominal radiology and the american pancreatic association. (24354378)
2014
2
Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma. (23260327)
2013
3
Prognostic significance of autophagy-related protein expression in resected pancreatic ductal adenocarcinoma. (23429496)
2013
4
The predictive role of p16 deletion, p53 deletion, and polysomy 9 and 17 in pancreatic ductal adenocarcinoma. (22782330)
2013
5
High microvessel density in pancreatic ductal adenocarcinoma is associated with high grade. (23579431)
2013
6
Effect of 3D matrix compositions on the efficacy of EGFR inhibition in pancreatic ductal adenocarcinoma cells. (23889305)
2013
7
Intraoperative irrigation cytology of the remnant pancreas to detect remnant distinct pancreatic ductal adenocarcinoma in patients with intraductal papillary mucinous neoplasm undergoing partial pancreatectomy. (24183345)
2013
8
Differential expression of cytochrome P450 omega-hydroxylase isoforms and their association with clinicopathological features in pancreatic ductal adenocarcinoma. (23846787)
2013
9
Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma. (23622132)
2013
10
Expression and clinical significance of apolipoprotein E in pancreatic ductal adenocarcinoma. (23609192)
2013
11
18-Fluorodeoxyglucose positron emission tomography does not aid in diagnosis of pancreatic ductal adenocarcinoma. (23353642)
2013
12
Profiling the potential tumor markers of pancreatic ductal adenocarcinoma using 2D-DIGE and MALDI-TOF-MS: up-regulation of Complement C3 and alpha-2-HS-glycoprotein. (23719603)
2013
13
Vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma. (22238308)
2012
14
Few genes are associated with the capability of pancreatic ductal adenocarcinoma cells to grow in the liver of nude rats. (23007550)
2012
15
Pancreatic ductal adenocarcinoma in hereditary diffuse gastric cancer. A case report. (21992816)
2012
16
Urine metabolic signature of pancreatic ductal adenocarcinoma by (1)h nuclear magnetic resonance: identification, mapping, and evolution. (22066465)
2012
17
Pancreatic ductal adenocarcinoma screening: new perspectives. (23049204)
2012
18
SMAD4 genetic alterations predict a worse prognosis in patients with pancreatic ductal adenocarcinoma. (22504380)
2012
19
Comparative evaluation of cancer stem cell markers in normal pancreas and pancreatic ductal adenocarcinoma. (21922151)
2012
20
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. (23201164)
2012
21
Preoperative serum C-reactive protein levels and post-operative lymph node ratio are important predictors of survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. (22406601)
2012
22
II_B Kinase I/ expression in pancreatic ductal adenocarcinoma. (21685032)
2011
23
Major molecular markers in pancreatic ductal adenocarcinoma and their roles in screening, diagnosis, prognosis, and treatment. (21673535)
2011
24
Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming growth factor-I^1 (TGF-I^)-induced L1CAM expression in human pancreatic ductal adenocarcinoma cells. (21109948)
2011
25
Improvement in treatment and outcome of pancreatic ductal adenocarcinoma in north China. (21484493)
2011
26
The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells. (21262926)
2011
27
Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma. (20484026)
2010
28
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. (20814421)
2010
29
Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma. (20531411)
2010
30
Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma. (20573371)
2010
31
A combined, rational approach towards inhibition of the MEK-ERK and mTOR pathways in pancreatic ductal adenocarcinoma: promise or deja vu? (19783905)
2009
32
A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells. (20037478)
2009
33
Prognostic significance of immunohistochemical RhoA expression on survival in pancreatic ductal adenocarcinoma: a high-throughput analysis. (18495213)
2008
34
Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma. (18416599)
2008
35
Genetic susceptibility in pancreatic ductal adenocarcinoma. (18076020)
2008
36
Apoptotic pathways in pancreatic ductal adenocarcinoma. (18652674)
2008
37
CYP1B1 polymorphisms and k-ras mutations in patients with pancreatic ductal adenocarcinoma. (18347981)
2008
38
The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. (18639493)
2008
39
Evaluation of topoisomerase IIa expression in pancreatic ductal adenocarcinoma: a pilot study using chromogenic in situ hybridization and immunohistochemistry on tissue microarrays. (17449965)
2007
40
Orthotopic model of human pancreatic ductal adenocarcinoma and cancer cachexia in nude mice. (21948162)
2007
41
Interleukin-4 cytotoxin therapy synergizes with gemcitabine in a mouse model of pancreatic ductal adenocarcinoma. (17942922)
2007
42
FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth. (16003754)
2006
43
Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. (15814630)
2005
44
Preoperative staging and evaluation of resectability in pancreatic ductal adenocarcinoma. (18333037)
2004
45
Lack of apoptosis in PanIN-1 and PanIN-2 lesions associated with pancreatic ductal adenocarcinoma is not dependent on K-ras status. (14508142)
2003
46
Cytoplasmic expression of laminin gamma2 chain correlates with postoperative hepatic metastasis and poor prognosis in patients with pancreatic ductal adenocarcinoma. (11920553)
2002
47
Characterisation of oestrogen receptor, progesterone receptor, trefoil factor 1, and epidermal growth factor and its receptor in pancreatic cystic neoplasms and pancreatic ductal adenocarcinoma. (12377812)
2002
48
Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma. (10950061)
2000
49
Ki-ras and p53 mutations in pancreatic ductal adenocarcinoma. (8927612)
1996
50
Bombesin inhibits growth of pancreatic ductal adenocarcinoma (H2T) in nude mice. (7809021)
1994

Genetic Variations for Pancreatic Ductal Adenocarcinoma

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Expression for genes affiliated with Pancreatic Ductal Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Ductal Adenocarcinoma

Search GEO for disease gene expression data for Pancreatic Ductal Adenocarcinoma.

Pathways for genes affiliated with Pancreatic Ductal Adenocarcinoma

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Pancreatic Ductal Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0SERPINB5, MIR224, MIR221, MIR10B, MIR181B1, MIR21
210.7MIR221, MIR181B1, MIR21

Compounds for genes affiliated with Pancreatic Ductal Adenocarcinoma

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GO Terms for genes affiliated with Pancreatic Ductal Adenocarcinoma

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16Gene Ontology
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Molecular functions related to Pancreatic Ductal Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent protein bindingGO:04830610.7S100PBP, S100P

Products for genes affiliated with Pancreatic Ductal Adenocarcinoma

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Sources for Pancreatic Ductal Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet