MCID: PNC041
MIFTS: 32

Pancreatic Ductal Adenocarcinoma malady

Summaries for Pancreatic Ductal Adenocarcinoma

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33MalaCards
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MalaCards: Pancreatic Ductal Adenocarcinoma, also known as ductal adenocarcinoma of the pancreas, is related to adenocarcinoma and pancreatitis, chronic. An important gene associated with Pancreatic Ductal Adenocarcinoma is SAGE1 (sarcoma antigen 1), and among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

Aliases & Classifications for Pancreatic Ductal Adenocarcinoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt
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Aliases & Descriptions:

pancreatic ductal adenocarcinoma 8 10 61
ductal adenocarcinoma of the pancreas 8


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Disease Ontology8 DOID:3498
NCIt40 C9120

Related Diseases for Pancreatic Ductal Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pancreatic Ductal Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.4SMAD4, MSLN, SERPINB5
2pancreatitis, chronic30.9SERPINB5, SMAD4, MSLN
3mucinous adenocarcinoma10.8
4hypoxia10.7
5pancreatic ductal carcinoma10.6
6autoimmune pancreatitis10.5
7papillary carcinoma10.4
8cystadenoma10.3
9pancreatic invasive intraductal papillary-mucinous carcinoma10.3
10pancreatic foamy gland adenocarcinoma10.3
11stomatitis10.3
12insulin resistance10.3
13renal clear cell carcinoma10.3
14clear cell adenocarcinoma10.3
15mucinous cystadenocarcinoma10.3
16acinar cell carcinoma10.3
17clear cell renal cell carcinoma10.3
18cystic fibrosis10.2
19hepatitis c10.2
20pancreatic mucinous cystadenoma10.2
21smooth muscle tumor10.2
22adenosquamous pancreas carcinoma10.2
23pancreatic acinar cell adenocarcinoma10.2
24ovarian mucinous adenocarcinoma10.2
25gastric papillary adenocarcinoma10.2
26hepatitis d10.2
27pancreatic serous cystadenoma10.2
28adenosquamous carcinoma10.2
29hepatitis a10.2
30breast adenocarcinoma10.2
31hereditary diffuse gastric cancer10.2
32wilms tumor10.2
33pancreatic agenesis10.2
34diffuse gastric cancer10.2
35hereditary pancreatitis10.2
36hepatitis c virus10.2
37breast cancer susceptibility10.2
38pancreatic cancer 410.2
39invasive mole10.2
40stomach cancer10.0SERPINB5, SMAD4
41prostate cancer10.0SMAD4, SERPINB5
42pancreatitis10.0SMAD4
43cervical cancer10.0SMAD4
44hepatocellular carcinoma10.0SMAD4, SERPINB5
45adenoma10.0SERPINB5, SMAD4
46colon cancer10.0SMAD4, SERPINB5
47ovarian cancer10.0SERPINB5, MSLN, SMAD4
48leiomyoma10.0SMAD4
49glioblastoma multiforme10.0SMAD4
50pancreatic cancer10.0MSLN, SERPINB5, SMAD4

Graphical network of the top 20 diseases related to Pancreatic Ductal Adenocarcinoma:



Diseases related to pancreatic ductal adenocarcinoma

Clinical Features for Pancreatic Ductal Adenocarcinoma

Drugs & Therapeutics for Pancreatic Ductal Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pancreatic Ductal Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Pancreatic Ductal Adenocarcinoma

Search NIH Clinical Center for Pancreatic Ductal Adenocarcinoma

Search CenterWatch for Pancreatic Ductal Adenocarcinoma

Genetic Tests for Pancreatic Ductal Adenocarcinoma

Anatomical Context for Pancreatic Ductal Adenocarcinoma

Sources:
31LifeMap Discovery™
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LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Pancreatic Ductal Adenocarcinoma:
id TissueAnatomical CompartmentCell Relevance
1 PancreasPancreatic Ducts  Affected by disease

Animal Models for Pancreatic Ductal Adenocarcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Pancreatic Ductal Adenocarcinoma

Sources:
51PubMed
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Articles related to Pancreatic Ductal Adenocarcinoma:

(show top 50)    (show all 617)
idTitleAuthorsYear
1
Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cells. (24297612)
2014
2
Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. (23891972)
2013
3
Detection of pancreatic ductal adenocarcinoma in mice by ultrasound imaging of thymocyte differentiation antigen 1. (23791701)
2013
4
MTA2 expression is a novel prognostic marker for pancreatic ductal adenocarcinoma. (23400716)
2013
5
Rare ALK expression but no ALK rearrangement in pancreatic ductal adenocarcinoma and neuroendocrine tumors. (23851431)
2013
6
Net expression inhibits the growth of pancreatic ductal adenocarcinoma cell PL45 in vitro and in vivo. (23469073)
2013
7
miR-15a inhibits cell proliferation and epithelial to mesenchymal transition in pancreatic ductal adenocarcinoma by down-regulating Bmi-1 expression. (24252251)
2013
8
Diagnostic and biological significance of microRNA-192 in pancreatic ductal adenocarcinoma. (23612862)
2013
9
Pancreatic ductal adenocarcinoma: is there a survival difference for R1 resections versus locally advanced unresectable tumors? What is a "true" R0 resection? (22968073)
2013
10
Clinical necessity of the immunohistochemical reassessment of para-aortic lymph nodes in resected pancreatic ductal adenocarcinoma. (24179493)
2013
11
A minimally invasive and simple screening test for detection of pancreatic ductal adenocarcinoma using biomarkers in duodenal juice. (23407480)
2013
12
Lumican expression in pancreatic ductal adenocarcinoma. (22951524)
2013
13
Expression of NEDD9 in pancreatic ductal adenocarcinoma and its clinical significance. (23247867)
2013
14
A case of pancreatic ductal adenocarcinoma with marked infiltration with IgG4-positive cells. (23661941)
2013
15
Functional Modules Analysis Based on Coexpression Network in Pancreatic Ductal Adenocarcinoma. (24185439)
2013
16
Clinical significance of RECK promoter methylation in pancreatic ductal adenocarcinoma. (23749490)
2013
17
Immunological Impact of Neoadjuvant Chemoradiotherapy in Patients with Borderline Resectable Pancreatic Ductal Adenocarcinoma. (24310792)
2013
18
The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance. (22272725)
2012
19
Serum high mobility group box-1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma. (22703527)
2012
20
Mast cells in pancreatic ductal adenocarcinoma. (22934272)
2012
21
Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101. (22943841)
2012
22
Stem cells as the root of pancreatic ductal adenocarcinoma. (22119145)
2012
23
Apoptosis and expression of the Bcl-2 family of proteins and P53 in human pancreatic ductal adenocarcinoma. (22024503)
2012
24
A case of synchronous pancreatic ductal adenocarcinoma and ovarian mucinous cystic neoplasm: use of kras mutation molecular phenotyping to demonstrate independent primary origin. (22690261)
2012
25
The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma. (22183185)
2012
26
Proteome of formalin-fixed paraffin-embedded pancreatic ductal adenocarcinoma and lymph node metastases. (22081483)
2012
27
Reduced expression of desmocollin 2 is an independent prognostic biomarker for shorter patients survival in pancreatic ductal adenocarcinoma. (21725043)
2011
28
microRNAs as markers of survival and chemoresistance in pancreatic ductal adenocarcinoma. (22117151)
2011
29
Nuclear position and shape deformation of chromosome 8 territories in pancreatic ductal adenocarcinoma. (21483101)
2011
30
Genexol inhibits primary tumour growth and metastases in gemcitabine-resistant pancreatic ductal adenocarcinoma. (21309930)
2011
31
Expression and regulation of nicotine receptor and osteopontin isoforms in human pancreatic ductal adenocarcinoma. (21630219)
2011
32
Tumour epithelial vimentin expression and outcome of pancreatic ductal adenocarcinomas. (21448168)
2011
33
Loss of Raf-1 kinase inhibitory protein in pancreatic ductal adenocarcinoma. (21080875)
2010
34
HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients. (20739850)
2010
35
MicroRNA-21 is induced early in pancreatic ductal adenocarcinoma precursor lesions. (20093556)
2010
36
Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma. (19326463)
2009
37
Combining fine needle aspiration with brushing cytology has improved yields in diagnosing pancreatic ductal adenocarcinoma. (19306410)
2009
38
Surgical bypass vs. endoscopic stenting for pancreatic ductal adenocarcinoma. (19590634)
2009
39
Synchronous autoimmune pancreatitis and infiltrating pancreatic ductal adenocarcinoma: case report and review of the literature. (18619645)
2008
40
Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. (18706098)
2008
41
Co-expression of KLK6 and KLK10 as prognostic factors for survival in pancreatic ductal adenocarcinoma. (18854834)
2008
42
Surgery for recurrent pancreatic ductal adenocarcinoma. (17414605)
2007
43
TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma. (16751802)
2006
44
EGFR alterations in pancreatic ductal adenocarcinoma: a chromogenic in situ hybridization analysis based on tissue microarrays. (16795991)
2006
45
Overexpression and elevated serum levels of phosphoglycerate kinase 1 in pancreatic ductal adenocarcinoma. (16493704)
2006
46
Prognostic significance of maspin in pancreatic ductal adenocarcinoma. (15053038)
2004
47
Increased expression of valosin-containing protein (p97) is associated with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma. (14761919)
2004
48
Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma. (15166270)
2004
49
Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. (12874021)
2003
50
Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and in chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas. (12120204)
2001

Genetic Variations for Pancreatic Ductal Adenocarcinoma

Expression for genes affiliated with Pancreatic Ductal Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Ductal Adenocarcinoma

Search GEO for disease gene expression data for Pancreatic Ductal Adenocarcinoma.

Pathways for genes affiliated with Pancreatic Ductal Adenocarcinoma

Sources:
30KEGG, 38NCBI BioSystems Database
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Pathways related to Pancreatic Ductal Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0SERPINB5, MIR224, MIR221, MIR10B, MIR181B1, MIR21
210.7MIR221, MIR181B1, MIR21

Compounds for genes affiliated with Pancreatic Ductal Adenocarcinoma

GO Terms for genes affiliated with Pancreatic Ductal Adenocarcinoma

Sources:
16Gene Ontology
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Molecular functions related to Pancreatic Ductal Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent protein bindingGO:04830610.7S100PBP, S100P

Products for genes affiliated with Pancreatic Ductal Adenocarcinoma

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Sources for Pancreatic Ductal Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet