MCID: PNC041
MIFTS: 35

Pancreatic Ductal Adenocarcinoma malady

Cancer diseases, Endocrine diseases categories
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Summaries for Pancreatic Ductal Adenocarcinoma

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Disease Ontology:8 A pancreas adenocarcinoma that derives from pancreatic duct cells.

MalaCards based summary: Pancreatic Ductal Adenocarcinoma, also known as ductal adenocarcinoma of the pancreas, is related to adenocarcinoma and pancreatitis. An important gene associated with Pancreatic Ductal Adenocarcinoma is MIR196A2 (microRNA 196a-2), and among its related pathways are miRNAs involved in DDR and MicroRNAs in cancer. Affiliated tissues include pancreas, lymph node and liver.

Aliases & Classifications for Pancreatic Ductal Adenocarcinoma

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Pancreatic Ductal Adenocarcinoma, Aliases & Descriptions:

Name: Pancreatic Ductal Adenocarcinoma 30 8 10 62
 
Ductal Adenocarcinoma of the Pancreas 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:3498
NCIt39 C9120

Related Diseases for Pancreatic Ductal Adenocarcinoma

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Graphical network of the top 20 diseases related to Pancreatic Ductal Adenocarcinoma:



Diseases related to pancreatic ductal adenocarcinoma

Symptoms for Pancreatic Ductal Adenocarcinoma

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Drugs & Therapeutics for Pancreatic Ductal Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Pancreatic Ductal Adenocarcinoma

Search NIH Clinical Center for Pancreatic Ductal Adenocarcinoma

Genetic Tests for Pancreatic Ductal Adenocarcinoma

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Anatomical Context for Pancreatic Ductal Adenocarcinoma

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MalaCards organs/tissues related to Pancreatic Ductal Adenocarcinoma:

32
Pancreas, Lymph node, Liver, Testes, Neutrophil, T cells, Smooth muscle, Skeletal muscle, Colon, Breast, Monocytes, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Pancreatic Ductal Adenocarcinoma:
id TissueAnatomical CompartmentCell Relevance
1 PancreasPancreatic Ducts  Affected by disease

Animal Models for Pancreatic Ductal Adenocarcinoma or affiliated genes

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Publications for Pancreatic Ductal Adenocarcinoma

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Articles related to Pancreatic Ductal Adenocarcinoma:

(show top 50)    (show all 611)
idTitleAuthorsYear
1
Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cells. (24297612)
2014
2
Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Pancreatic Ductal Adenocarcinoma at 3.0-T Magnetic Resonance: Correlation With Histopathology. (25340589)
2014
3
Growth hormone receptor inhibition decreases the growth and metastasis of pancreatic ductal adenocarcinoma. (25301264)
2014
4
miR-545 inhibited Pancreatic ductal adenocarcinoma growth by targeting RIG-I. (25315416)
2014
5
Putative tumor suppressor gene SEL1L was downregulated by aberrantly upregulated hsa-mir-155 in human pancreatic ductal adenocarcinoma. (23661430)
2013
6
Differential expression of RBM5 and KRAS in pancreatic ductal adenocarcinoma and their association with clinicopathological features. (23425895)
2013
7
Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma. (23260327)
2013
8
MicroRNA-21 in pancreatic ductal adenocarcinoma tumor-associated fibroblasts promotes metastasis. (23991015)
2013
9
Prognostic significance of autophagy-related protein expression in resected pancreatic ductal adenocarcinoma. (23429496)
2013
10
The predictive role of p16 deletion, p53 deletion, and polysomy 9 and 17 in pancreatic ductal adenocarcinoma. (22782330)
2013
11
Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma? (22436573)
2012
12
Clinical profiles and long-term outcomes of patients with pancreatic ductal adenocarcinoma and diabetes mellitus. (22423386)
2012
13
The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance. (22272725)
2012
14
Serum high mobility group box-1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma. (22703527)
2012
15
Prognostic significance of PUMA in pancreatic ductal adenocarcinoma. (23321162)
2012
16
Can pharmacogenomics guide effective anticancer therapy in pancreatic ductal adenocarcinoma? (22838942)
2012
17
A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in Caucasians. (21656579)
2012
18
Reduced expression of desmocollin 2 is an independent prognostic biomarker for shorter patients survival in pancreatic ductal adenocarcinoma. (21725043)
2011
19
Differentiating pancreatic ductal adenocarcinoma from pancreatic serous cystadenoma, mucinous cystadenoma, and a pseudocyst with detailed analysis of cystic features on CT scans: a preliminary study. (21430935)
2011
20
Clinicopathologic correlation of beclin-1 expression in pancreatic ductal adenocarcinoma. (21420796)
2011
21
MicroRNAs in pancreatic ductal adenocarcinoma. (21412491)
2011
22
Loss of heterozygosity status of D9S105 marker is associated with downregulation of KrA1ppel-like factor 4 expression in pancreatic ductal adenocarcinoma and pancreatic intraepithelial lesions. (21412023)
2011
23
Galectin-1 secreted by activated stellate cells in pancreatic ductal adenocarcinoma stroma promotes proliferation and invasion of pancreatic cancer cells: an in vitro study on the microenvironment of pancreatic ductal adenocarcinoma. (21747316)
2011
24
microRNA-10b: a new marker or the marker of pancreatic ductal adenocarcinoma? (21816909)
2011
25
Elevated transcript levels from the MDM2 P1 promoter and low p53 transcript levels are associated with poor prognosis in human pancreatic ductal adenocarcinoma. (21404460)
2011
26
Positive mobilization margins alone do not influence survival following pancreatico-duodenectomy for pancreatic ductal adenocarcinoma. (20485150)
2010
27
Inhibition of ankyrin-B expression reduces growth and invasion of human pancreatic ductal adenocarcinoma. (21042036)
2010
28
Ten years of experience with resection of left-sided pancreatic ductal adenocarcinoma: evolution and initial experience to a laparoscopic approach. (20054579)
2010
29
Novel drug targets based on association between inflammation and pancreatic ductal adenocarcinoma. (20601821)
2010
30
High TRAIL death receptor 4 and decoy receptor 2 expression correlates with significant cell death in pancreatic ductal adenocarcinoma patients. (18981952)
2009
31
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. (19208345)
2009
32
A combined, rational approach towards inhibition of the MEK-ERK and mTOR pathways in pancreatic ductal adenocarcinoma: promise or deja vu? (19783905)
2009
33
Screening for early pancreatic ductal adenocarcinoma: an urgent call! (19287101)
2009
34
Patterns of recurrence after curative resection of pancreatic ductal adenocarcinoma. (19131205)
2009
35
Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma. (19326463)
2009
36
Preoperative resolution of jaundice following biliary stenting predicts more favourable early survival in resected pancreatic ductal adenocarcinoma. (18787902)
2008
37
Pancreatic ductal adenocarcinoma: cellular origin, signaling pathways and stroma contribution. (18724072)
2008
38
Synchronous autoimmune pancreatitis and infiltrating pancreatic ductal adenocarcinoma: case report and review of the literature. (18619645)
2008
39
Expression and potential function of the CXC chemokine CXCL16 in pancreatic ductal adenocarcinoma. (18636150)
2008
40
Prognostic significance of immunohistochemical RhoA expression on survival in pancreatic ductal adenocarcinoma: a high-throughput analysis. (18495213)
2008
41
Evaluation of topoisomerase IIa expression in pancreatic ductal adenocarcinoma: a pilot study using chromogenic in situ hybridization and immunohistochemistry on tissue microarrays. (17449965)
2007
42
Simultaneous deregulation of p16 and cyclin D1 genes in pancreatic ductal adenocarcinoma: a combined immunohistochemistry and image analysis study based on tissue microarrays. (17600882)
2007
43
Cancer risk among the relatives of patients with pancreatic ductal adenocarcinoma. (17912010)
2007
44
GADD45alpha is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability. (16353139)
2006
45
Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alpha converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinoma. (16982746)
2006
46
Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. (15814630)
2005
47
Prognostic value of VEGF in human pancreatic ductal adenocarcinoma. (15053037)
2004
48
Prognostic significance of maspin in pancreatic ductal adenocarcinoma. (15053038)
2004
49
Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma. (12402154)
2002
50
Foamy gland pattern of pancreatic ductal adenocarcinoma: a deceptively benign-appearing variant. (10757396)
2000

Variations for Pancreatic Ductal Adenocarcinoma

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Expression for genes affiliated with Pancreatic Ductal Adenocarcinoma

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Expression patterns in normal tissues for genes affiliated with Pancreatic Ductal Adenocarcinoma

Search GEO for disease gene expression data for Pancreatic Ductal Adenocarcinoma.

Pathways for genes affiliated with Pancreatic Ductal Adenocarcinoma

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Pathways related to Pancreatic Ductal Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4MIR21, MIR181B1
28.6MIR21, MIR10B, MIR224, MIR181B1

Compounds for genes affiliated with Pancreatic Ductal Adenocarcinoma

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GO Terms for genes affiliated with Pancreatic Ductal Adenocarcinoma

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Products for genes affiliated with Pancreatic Ductal Adenocarcinoma

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Sources for Pancreatic Ductal Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet