MCID: PNC041
MIFTS: 34

Pancreatic Ductal Adenocarcinoma malady

Cancer diseases, Endocrine diseases categories
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Summaries for Pancreatic Ductal Adenocarcinoma

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34MalaCards
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MalaCards: Pancreatic Ductal Adenocarcinoma, also known as ductal adenocarcinoma of the pancreas, is related to adenocarcinoma and pancreatitis. An important gene associated with Pancreatic Ductal Adenocarcinoma is MIR196A2 (microRNA 196a-2), and among its related pathways are miRNAs involved in DDR and MicroRNAs in cancer. Affiliated tissues include pancreas, lymph node and liver.

Aliases & Classifications for Pancreatic Ductal Adenocarcinoma

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
app/views/elements/card/aliases_descriptions.ctp (line 56)
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Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreatic ductal adenocarcinoma 9 11 63
ductal adenocarcinoma of the pancreas 9


External Ids:

Disease Ontology9 DOID:3498
NCIt41 C9120

Related Diseases for Pancreatic Ductal Adenocarcinoma

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Pancreatic Ductal Adenocarcinoma:



Diseases related to pancreatic ductal adenocarcinoma

Symptoms for Pancreatic Ductal Adenocarcinoma

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Drugs & Therapeutics for Pancreatic Ductal Adenocarcinoma

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Sources:
43NIH Clinical Center, 7ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pancreatic Ductal Adenocarcinoma

Search NIH Clinical Center for Pancreatic Ductal Adenocarcinoma

Genetic Tests for Pancreatic Ductal Adenocarcinoma

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Anatomical Context for Pancreatic Ductal Adenocarcinoma

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Sources:
32LifeMap Discovery™, 34MalaCards
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MalaCards organs/tissues related to Pancreatic Ductal Adenocarcinoma:

34
Pancreas, Lymph node, Liver, T cells, Smooth muscle, Skeletal muscle, Testes, Breast, Monocytes, Endothelial, Colon

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Pancreatic Ductal Adenocarcinoma:
id TissueAnatomical CompartmentCell Relevance
1 PancreasPancreatic Ducts  Affected by disease

Animal Models for Pancreatic Ductal Adenocarcinoma or affiliated genes

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Publications for Pancreatic Ductal Adenocarcinoma

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Sources:
53PubMed
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Articles related to Pancreatic Ductal Adenocarcinoma:

(show top 50)    (show all 590)
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idTitleAuthorsYear
1
Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cells. (24297612)
2014
2
Putative tumor suppressor gene SEL1L was downregulated by aberrantly upregulated hsa-mir-155 in human pancreatic ductal adenocarcinoma. (23661430)
2013
3
Differential expression of RBM5 and KRAS in pancreatic ductal adenocarcinoma and their association with clinicopathological features. (23425895)
2013
4
Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma. (23260327)
2013
5
MicroRNA-21 in pancreatic ductal adenocarcinoma tumor-associated fibroblasts promotes metastasis. (23991015)
2013
6
Prognostic significance of autophagy-related protein expression in resected pancreatic ductal adenocarcinoma. (23429496)
2013
7
The predictive role of p16 deletion, p53 deletion, and polysomy 9 and 17 in pancreatic ductal adenocarcinoma. (22782330)
2013
8
Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma? (22436573)
2012
9
Clinical profiles and long-term outcomes of patients with pancreatic ductal adenocarcinoma and diabetes mellitus. (22423386)
2012
10
The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance. (22272725)
2012
11
Serum high mobility group box-1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma. (22703527)
2012
12
Prognostic significance of PUMA in pancreatic ductal adenocarcinoma. (23321162)
2012
13
Can pharmacogenomics guide effective anticancer therapy in pancreatic ductal adenocarcinoma? (22838942)
2012
14
A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in Caucasians. (21656579)
2012
15
Reduced expression of desmocollin 2 is an independent prognostic biomarker for shorter patients survival in pancreatic ductal adenocarcinoma. (21725043)
2011
16
Differentiating pancreatic ductal adenocarcinoma from pancreatic serous cystadenoma, mucinous cystadenoma, and a pseudocyst with detailed analysis of cystic features on CT scans: a preliminary study. (21430935)
2011
17
Clinicopathologic correlation of beclin-1 expression in pancreatic ductal adenocarcinoma. (21420796)
2011
18
MicroRNAs in pancreatic ductal adenocarcinoma. (21412491)
2011
19
Loss of heterozygosity status of D9S105 marker is associated with downregulation of KrA1ppel-like factor 4 expression in pancreatic ductal adenocarcinoma and pancreatic intraepithelial lesions. (21412023)
2011
20
Galectin-1 secreted by activated stellate cells in pancreatic ductal adenocarcinoma stroma promotes proliferation and invasion of pancreatic cancer cells: an in vitro study on the microenvironment of pancreatic ductal adenocarcinoma. (21747316)
2011
21
microRNA-10b: a new marker or the marker of pancreatic ductal adenocarcinoma? (21816909)
2011
22
Elevated transcript levels from the MDM2 P1 promoter and low p53 transcript levels are associated with poor prognosis in human pancreatic ductal adenocarcinoma. (21404460)
2011
23
microRNAs as markers of survival and chemoresistance in pancreatic ductal adenocarcinoma. (22117151)
2011
24
Positive mobilization margins alone do not influence survival following pancreatico-duodenectomy for pancreatic ductal adenocarcinoma. (20485150)
2010
25
Inhibition of ankyrin-B expression reduces growth and invasion of human pancreatic ductal adenocarcinoma. (21042036)
2010
26
Ten years of experience with resection of left-sided pancreatic ductal adenocarcinoma: evolution and initial experience to a laparoscopic approach. (20054579)
2010
27
Novel drug targets based on association between inflammation and pancreatic ductal adenocarcinoma. (20601821)
2010
28
High TRAIL death receptor 4 and decoy receptor 2 expression correlates with significant cell death in pancreatic ductal adenocarcinoma patients. (18981952)
2009
29
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. (19208345)
2009
30
A combined, rational approach towards inhibition of the MEK-ERK and mTOR pathways in pancreatic ductal adenocarcinoma: promise or deja vu? (19783905)
2009
31
Screening for early pancreatic ductal adenocarcinoma: an urgent call! (19287101)
2009
32
Patterns of recurrence after curative resection of pancreatic ductal adenocarcinoma. (19131205)
2009
33
Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma. (19326463)
2009
34
Translational advances and novel therapies for pancreatic ductal adenocarcinoma: hope or hype? (19919723)
2009
35
Preoperative resolution of jaundice following biliary stenting predicts more favourable early survival in resected pancreatic ductal adenocarcinoma. (18787902)
2008
36
Pancreatic ductal adenocarcinoma: cellular origin, signaling pathways and stroma contribution. (18724072)
2008
37
Synchronous autoimmune pancreatitis and infiltrating pancreatic ductal adenocarcinoma: case report and review of the literature. (18619645)
2008
38
Expression and potential function of the CXC chemokine CXCL16 in pancreatic ductal adenocarcinoma. (18636150)
2008
39
Prognostic significance of immunohistochemical RhoA expression on survival in pancreatic ductal adenocarcinoma: a high-throughput analysis. (18495213)
2008
40
Evaluation of topoisomerase IIa expression in pancreatic ductal adenocarcinoma: a pilot study using chromogenic in situ hybridization and immunohistochemistry on tissue microarrays. (17449965)
2007
41
Simultaneous deregulation of p16 and cyclin D1 genes in pancreatic ductal adenocarcinoma: a combined immunohistochemistry and image analysis study based on tissue microarrays. (17600882)
2007
42
Cancer risk among the relatives of patients with pancreatic ductal adenocarcinoma. (17912010)
2007
43
GADD45alpha is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability. (16353139)
2006
44
Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alpha converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinoma. (16982746)
2006
45
Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. (15814630)
2005
46
Prognostic value of VEGF in human pancreatic ductal adenocarcinoma. (15053037)
2004
47
Prognostic significance of maspin in pancreatic ductal adenocarcinoma. (15053038)
2004
48
Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma. (12402154)
2002
49
Foamy gland pattern of pancreatic ductal adenocarcinoma: a deceptively benign-appearing variant. (10757396)
2000
50
K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma. (11102889)
2000

Variations for Pancreatic Ductal Adenocarcinoma

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app/views/elements/card/genetic_variations.ctp (line 43)
Array
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Expression for genes affiliated with Pancreatic Ductal Adenocarcinoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Ductal Adenocarcinoma

Search GEO for disease gene expression data for Pancreatic Ductal Adenocarcinoma.

Pathways for genes affiliated with Pancreatic Ductal Adenocarcinoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Pancreatic Ductal Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4MIR21, MIR181B1
28.6MIR21, MIR10B, MIR224, MIR181B1

Compounds for genes affiliated with Pancreatic Ductal Adenocarcinoma

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GO Terms for genes affiliated with Pancreatic Ductal Adenocarcinoma

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Products for genes affiliated with Pancreatic Ductal Adenocarcinoma

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  • Antibodies
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Sources for Pancreatic Ductal Adenocarcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet