MCID: PNC041
MIFTS: 38

Pancreatic Ductal Adenocarcinoma malady

Endocrine diseases category

Summaries for Pancreatic Ductal Adenocarcinoma

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32MalaCards
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MalaCards: Pancreatic Ductal Adenocarcinoma, also known as ductal adenocarcinoma of the pancreas, is related to adenocarcinoma and pancreatitis. An important gene associated with Pancreatic Ductal Adenocarcinoma is SAGE1 (sarcoma antigen 1), and among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR. Affiliated tissues include pancreas, lymph node and liver.

Aliases & Classifications for Pancreatic Ductal Adenocarcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreatic ductal adenocarcinoma 8 10 60
ductal adenocarcinoma of the pancreas 8


External Ids:

Disease Ontology8 DOID:3498
NCIt39 C9120

Related Diseases for Pancreatic Ductal Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Pancreatic Ductal Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.3SMAD4, MSLN, SERPINB5
2pancreatitis32.3SMAD4
3pancreatic cancer31.3MSLN, SERPINB5, SMAD4
4pancreas adenocarcinoma10.9
5mucinous adenocarcinoma10.8
6papillary adenocarcinoma10.7
7pancreatic intraductal papillary-mucinous neoplasm10.7
8pancreatic ductal carcinoma10.6
9adenocarcinoma in situ10.5
10papillary carcinoma10.4
11duodenitis10.4
12gastric adenocarcinoma10.4
13cystadenoma10.3
14alcoholic pancreatitis10.3
15pancreatic invasive intraductal papillary-mucinous carcinoma10.3
16pancreatic foamy gland adenocarcinoma10.3
17cholangiocarcinoma10.3
18hepatitis10.3
19pancreatic cystadenoma10.3
20stomatitis10.3
21renal clear cell carcinoma10.3
22clear cell adenocarcinoma10.3
23mucinous cystadenocarcinoma10.3
24acinar cell carcinoma10.3
25cystadenocarcinoma10.3
26renal cell carcinoma10.3
27cystic fibrosis10.2
28pancreatic mucinous cystadenoma10.2
29smooth muscle tumor10.2
30adenosquamous pancreas carcinoma10.2
31pancreatic acinar cell adenocarcinoma10.2
32ovarian mucinous adenocarcinoma10.2
33gastric papillary adenocarcinoma10.2
34hepatitis b10.2
35pancreatic serous cystadenoma10.2
36adenosquamous carcinoma10.2
37hepatitis a10.2
38breast adenocarcinoma10.2
39breast cancer10.2
40colon adenocarcinoma10.2
41diabetes mellitus10.2
42gastric diffuse adenocarcinoma10.2
43melanoma10.2
44neuroendocrine tumor10.2
45ovarian mucinous neoplasm10.2
46hereditary diffuse gastric cancer10.2
47pancreatitis, chronic10.0SERPINB5, SMAD4, MSLN
48stomach cancer10.0SERPINB5, SMAD4
49prostate cancer10.0SMAD4, SERPINB5
50cervical cancer10.0SMAD4

Graphical network of the top 20 diseases related to Pancreatic Ductal Adenocarcinoma:



Diseases related to pancreatic ductal adenocarcinoma

Clinical Features for Pancreatic Ductal Adenocarcinoma

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Drugs & Therapeutics for Pancreatic Ductal Adenocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pancreatic Ductal Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Pancreatic Ductal Adenocarcinoma

Search NIH Clinical Center for Pancreatic Ductal Adenocarcinoma

Search CenterWatch for Pancreatic Ductal Adenocarcinoma

Genetic Tests for Pancreatic Ductal Adenocarcinoma

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Anatomical Context for Pancreatic Ductal Adenocarcinoma

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Pancreatic Ductal Adenocarcinoma:

32
Pancreas, Lymph node, Liver, Endothelial, T cells, Colon, Smooth muscle, Monocytes, Breast, Skeletal muscle, Testes

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Pancreatic Ductal Adenocarcinoma:
id TissueAnatomical CompartmentCell Relevance
1 PancreasPancreatic Ducts  Affected by disease

Animal Models for Pancreatic Ductal Adenocarcinoma or affiliated genes

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Publications for Pancreatic Ductal Adenocarcinoma

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50PubMed
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Articles related to Pancreatic Ductal Adenocarcinoma:

(show top 50)    (show all 615)
idTitleAuthorsYear
1
Key endoscopic ultrasound features of pancreatic ductal adenocarcinoma smaller than 20 mm. (24417737)
2014
2
Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma. (23754313)
2014
3
Expression of urocortin in pancreatic ductal adenocarcinoma and pancreatic intraepithelial neoplasia. (23755913)
2014
4
MicroRNA-21 in pancreatic ductal adenocarcinoma tumor-associated fibroblasts promotes metastasis. (23991015)
2013
5
RABL6A Promotes Oxaliplatin Resistance in Tumor Cells and Is a New Marker of Survival for Resected Pancreatic Ductal Adenocarcinoma Patients. (24167655)
2013
6
Epigenetic regulation and role of metastasis suppressor genes in pancreatic ductal adenocarcinoma. (23718921)
2013
7
Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma. (24111684)
2013
8
IL-1I+ expression in pancreatic ductal adenocarcinoma affects the tumor cell migration and is regulated by the p38MAPK signaling pathway. (23951028)
2013
9
Safety and efficacy of neoadjuvant FOLFIRINOX treatment in a series of patients with borderline resectable pancreatic ductal adenocarcinoma. (23445338)
2013
10
High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma. (24088390)
2013
11
Neoadjuvant chemotherapy with gemcitabine and S-1 for resectable and borderline pancreatic ductal adenocarcinoma: results from a prospective multi-institutional phase 2 trial. (23838925)
2013
12
Prognostic significance of PUMA in pancreatic ductal adenocarcinoma. (23321162)
2012
13
Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma. (22086503)
2012
14
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. (22699621)
2012
15
Radiofrequency ablation of liver metastasis in patients with locally controlled pancreatic ductal adenocarcinoma. (22525021)
2012
16
Expression of the adipocytokine resistin and its association with the clinicopathological features and prognosis of pancreatic ductal adenocarcinoma. (23162631)
2012
17
Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration. (22323115)
2012
18
Postoperative prognostic predictors of pancreatic ductal adenocarcinoma: clinical analysis and immunoprofile on tissue microarrays. (22395988)
2012
19
Loss of heterozygosity status of D9S105 marker is associated with downregulation of KrA1ppel-like factor 4 expression in pancreatic ductal adenocarcinoma and pancreatic intraepithelial lesions. (21412023)
2011
20
Elevated transcript levels from the MDM2 P1 promoter and low p53 transcript levels are associated with poor prognosis in human pancreatic ductal adenocarcinoma. (21404460)
2011
21
Tissue biomarkers for prognosis in pancreatic ductal adenocarcinoma: a systematic review and meta-analysis. (21444679)
2011
22
Down-regulation of Bax-interacting factor 1 in human pancreatic ductal adenocarcinoma. (21283040)
2011
23
Subject review: pancreatic ductal adenocarcinoma in the setting of mutations in the cystic fibrosis transmembrane conductance regulator gene: case report and review of the literature. (21809164)
2011
24
Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCD4) in pancreatic ductal adenocarcinoma. (21088996)
2011
25
Pancreas-protocol imaging at a high-volume center leads to improved preoperative staging of pancreatic ductal adenocarcinoma. (21484522)
2011
26
Clinical significance of serum levels of immune-associated molecules, uric acid and soluble MHC class I chain-related molecules A and B, as diagnostic tumor markers for pancreatic ductal adenocarcinoma. (21615621)
2011
27
Role of the lymph node ratio in pancreatic ductal adenocarcinoma. Impact on patient stratification and prognosis. (21713779)
2011
28
Impact of death receptor signaling on the malignancy of pancreatic ductal adenocarcinoma. (21129814)
2011
29
Hypoxia inducible BHLHB2 is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. (20863812)
2010
30
Positive expression of L1-CAM is associated with perineural invasion and poor outcome in pancreatic ductal adenocarcinoma. (20162456)
2010
31
High levels of expression of human stromal cell-derived factor-1 are associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma. (20732965)
2010
32
Elevated L1CAM expression in precursor lesions and primary and metastastic tissues of pancreatic ductal adenocarcinoma. (20811670)
2010
33
Decreased expression of angiotensin-converting enzyme 2 in pancreatic ductal adenocarcinoma is associated with tumor progression. (19212105)
2009
34
Prognostic relevance of extracapsular lymph node involvement in pancreatic ductal adenocarcinoma. (19649555)
2009
35
MicroRNAs in pancreatic ductal adenocarcinoma: new diagnostic and therapeutic clues. (19077456)
2009
36
Actinin-4 expression in primary and metastasized pancreatic ductal adenocarcinoma. (19672209)
2009
37
Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma. (19077459)
2009
38
Preoperative resolution of jaundice following biliary stenting predicts more favourable early survival in resected pancreatic ductal adenocarcinoma. (18787902)
2008
39
Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma. (18708761)
2008
40
Pancreatic ductal adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia: report of a case. (17897923)
2007
41
Neurotensin is a versatile modulator of in vitro human pancreatic ductal adenocarcinoma cell (PDAC) migration. (17641415)
2007
42
Preoperative lymphocyte count as a prognostic factor in resected pancreatic ductal adenocarcinoma. (18345294)
2007
43
Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas. (16774944)
2006
44
HER2/neu expression and gene alterations in pancreatic ductal adenocarcinoma: a comparative immunohistochemistry and chromogenic in situ hybridization study based on tissue microarrays and computerized image analysis. (16685109)
2006
45
The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma. (16618736)
2006
46
Monoclonal antibody therapies targeting pancreatic ductal adenocarcinoma. (17430101)
2006
47
Increased expression of tissue transglutaminase in pancreatic ductal adenocarcinoma and its implications in drug resistance and metastasis. (17079475)
2006
48
Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. (11786397)
2002
49
Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. (11943721)
2002
50
Phenotypical characteristics of undifferentiated carcinoma of the pancreas: a comparison with pancreatic ductal adenocarcinoma and relevance of E-cadherin, alpha catenin and beta catenin expression. (11410776)
2001

Genetic Variations for Pancreatic Ductal Adenocarcinoma

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Expression for genes affiliated with Pancreatic Ductal Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Ductal Adenocarcinoma

Search GEO for disease gene expression data for Pancreatic Ductal Adenocarcinoma.

Pathways for genes affiliated with Pancreatic Ductal Adenocarcinoma

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Pancreatic Ductal Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0SERPINB5, MIR224, MIR221, MIR10B, MIR181B1, MIR21
210.7MIR221, MIR181B1, MIR21

Compounds for genes affiliated with Pancreatic Ductal Adenocarcinoma

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GO Terms for genes affiliated with Pancreatic Ductal Adenocarcinoma

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16Gene Ontology
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Molecular functions related to Pancreatic Ductal Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent protein bindingGO:04830610.7S100PBP, S100P

Products for genes affiliated with Pancreatic Ductal Adenocarcinoma

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Sources for Pancreatic Ductal Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet