MCID: PNC013
MIFTS: 40

Pancreatic Ductal Carcinoma malady

Cancer diseases, Endocrine diseases categories

Summaries for Pancreatic Ductal Carcinoma

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Disease Ontology:9 A pancreatic carcinoma located in the pancreatic duct.

MalaCards based summary: Pancreatic Ductal Carcinoma, also known as malignant neoplasm of duct of wirsung, is related to cystadenocarcinoma and pancreatic cancer. An important gene associated with Pancreatic Ductal Carcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and O-linked glycosylation of mucins. The drugs gemcitabine and gemcitabine hydrochloride and the compounds lead and nucleoside have been mentioned in the context of this disorder. Affiliated tissues include the pancreatic duct, pancreas and endothelial, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Pancreatic Ductal Carcinoma

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 27ICD9CM, 55SNOMED-CT, 25ICD10
See all sources

Pancreatic Ductal Carcinoma, Aliases & Descriptions:

Name: Pancreatic Ductal Carcinoma 9
Malignant Neoplasm of Duct of Wirsung 9
Malignant Neoplasm of Pancreatic Duct 60
 
Carcinoma, Pancreatic Ductal 60
Carcinoma Pancreatic Ductal 43
Pancreatic Duct Cancer 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:3587
ICD9CM27 157.3
SNOMED-CT55 187793004, 93939009
ICD1025 C25.3

Related Diseases for Pancreatic Ductal Carcinoma

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Diseases related to Pancreatic Ductal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1cystadenocarcinoma30.4MUC2, MUC1
2pancreatic cancer30.4NTS, MUC2
3adenoma29.8MUC2, MUC1, MUC6, NTS
4pancreatitis11.1
5endotheliitis10.4
6biliary papillomatosis10.3MUC6, MUC2
7pseudomyxoma peritonei10.2MUC6, MUC2
8bronchiolo-alveolar adenocarcinoma10.2MUC6, MUC2
9barrett esophagus/esophageal adenocarcinoma10.2MUC6, MUC2
10microcystic adenoma10.2
11ovarian serous carcinoma10.2
12adenosquamous pancreas carcinoma10.2
13pancreatic cystadenocarcinoma10.2
14hypoxia10.2
15microinvasive gastric cancer10.2MUC2, TYMP
16gallbladder cancer10.2MUC2, TYMP
17gastritis10.2MUC6, NTS
18allergic rhinitis10.1MUC2, PFN1
19adenomatous polyposis coli10.1MUC2, MUC6
20papillary adenocarcinoma10.1MUC2, MUC1
21tubular adenocarcinoma10.1MUC1, MUC2
22mucoepidermoid carcinoma10.1MUC2, MUC1
23bladder cancer, somatic10.1MUC2, TYMP
24colon adenocarcinoma10.1NTS, MUC2
25papillary carcinoma10.0MUC1, MUC2
26gastric adenocarcinoma10.0TYMP, MUC2
27pancreatitis, hereditary10.0NTS, MUC6, MUC2
28cholangiocarcinoma10.0MUC1, MUC2
29cystic fibrosis10.0NTS, MUC6, MUC2
30endometrial cancer10.0MUC1, TYMP
31carcinoid syndrome10.0NTS, MUC1
32gastric cancer, somatic9.9TYMP, MUC2, MUC6
33cholera9.9NTS, MUC2
34colorectal cancer9.9TYMP, MUC2, NTS
35lung cancer9.9TYMP, MUC2, NTS
36adenosquamous carcinoma9.8MUC1, MUC2, TYMP
37meningioma, familial9.8MUC1, NTS
38ovarian cancer, somatic9.8MUC1, MUC2, TYMP
39stomach cancer9.6MUC6, MUC1, MUC2, TYMP
40breast cancer9.6MUC6, MUC1, MUC2, TYMP
41tongue squamous cell carcinoma9.6MUC6, MUC1, MUC2, TYMP
42adenocarcinoma9.4TYMP, MUC2, MUC1, MUC6, NTS

Graphical network of the top 20 diseases related to Pancreatic Ductal Carcinoma:



Diseases related to pancreatic ductal carcinoma

Symptoms for Pancreatic Ductal Carcinoma

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Drugs & Therapeutics for Pancreatic Ductal Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Pancreatic Ductal Carcinoma

Search NIH Clinical Center for Pancreatic Ductal Carcinoma

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Pancreatic Ductal Carcinoma

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Anatomical Context for Pancreatic Ductal Carcinoma

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MalaCards organs/tissues related to Pancreatic Ductal Carcinoma:

31
Pancreas, Endothelial, Bone marrow, Bone, Liver

FMA organs/tissues related to Pancreatic Ductal Carcinoma:

14
The pancreatic duct

Animal Models for Pancreatic Ductal Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Pancreatic Ductal Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6NTS, MUC1, MUC2, PFN1, TYMP

Publications for Pancreatic Ductal Carcinoma

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Articles related to Pancreatic Ductal Carcinoma:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Clinicopathological Significance of ASC-Amino Acid Transporter 2 (ASCT2) Expression in Pancreatic Ductal Carcinoma. (24845232)
2014
2
Alteration of strain ratio evaluated by transabdominal ultrasound elastography may predict the efficacy of preoperative chemoradiation performed for pancreatic ductal carcinoma: preliminary results. (24901166)
2014
3
Successful management of metachronous liver metastasis after pancreaticoduodectomy for pancreatic ductal carcinoma using hepatectomy and chemotherapy: a case report. (24778053)
2014
4
Pancreatic intraglandular metastasis predicts poorer outcome in postoperative patients with pancreatic ductal carcinoma. (23648465)
2013
5
Preoperative platelet-lymphocyte ratio in resected pancreatic ductal carcinoma: is it meaningful? (20579970)
2012
6
Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue. (22892044)
2012
7
Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model. (22190076)
2012
8
Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma. (21841817)
2012
9
Expression of KL-6/MUC1 in pancreatic ductal carcinoma and its potential relationship with I^-catenin in tumor progression. (21466814)
2011
10
Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-1 and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1. (21272935)
2011
11
Cytologic features of pancreatic intraepithelial neoplasia and pancreatitis: potential pitfalls in the diagnosis of pancreatic ductal carcinoma. (20730891)
2011
12
KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma. (21224073)
2011
13
Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology. (19856421)
2010
14
Expression of EGF and EGFR strongly correlates with metastasis of pancreatic ductal carcinoma. (18505086)
2008
15
Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma. (19020717)
2008
16
Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy. (17072983)
2006
17
Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma. (15985168)
2005
18
Factors predicting recurrence after resection of pancreatic ductal carcinoma. (15968250)
2005
19
Evaluation of vascular signal in pancreatic ductal carcinoma using contrast enhanced ultrasonography: effect of systemic chemotherapy. (15951559)
2005
20
Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A. (16335935)
2005
21
Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta. (14973050)
2004
22
A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile. (15258755)
2004
23
Evaluation of blood flow in pancreatic ductal carcinoma using contrast-enhanced, wide-band Doppler ultrasonography: correlation with tumor characteristics and vascular endothelial growth factor. (15084983)
2004
24
Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays. (15548371)
2004
25
A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform. (12692724)
2003
26
Expressions of angiogenic factors in pancreatic ductal carcinoma: a correlative study with clinicopathologic parameters and patient survival. (12717266)
2003
27
Expression of transcription factor E2F-1 in pancreatic ductal carcinoma: an immunohistochemical study. (12650514)
2003
28
Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinoma. (12824920)
2003
29
MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration. (14681945)
2003
30
Vascular endothelial growth factor mediated angiogenic potential of pancreatic ductal carcinomas enhanced by hypoxia: an in vitro and in vivo study. (12448000)
2002
31
The molecular genetics of pancreatic ductal carcinoma. (12370658)
2002
32
Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. (12429967)
2002
33
Endocrine and intermediate cells in pancreatic ductal carcinoma and in chronic pancreatitis. (12533945)
2002
34
Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. (11238189)
2001
35
Heterogeneic distribution of thymidine phosphorylase between primary tumors and metastatic lesions of human pancreatic ductal carcinoma: implications for the efficacy of chemotherapy with 5-FU or its derivatives. (11391857)
2001
36
A case of small pancreatic ductal carcinoma accompanied by intraductal mucin-producing pancreatic tumors. (10824701)
2000
37
Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation. (9477096)
1998
38
Ki-ras and p53 gene mutations in pancreatic ductal carcinoma: a relationship with tumor phenotype and survival. (10076772)
1998
39
Isolation of a pancreas-specific gene located on human chromosome 14q31: expression analysis in human pancreatic ductal carcinomas. (9417916)
1997
40
p53 protein overexpression and K-ras codon 12 mutation in pancreatic ductal carcinoma: correlation with histologic factors. (9293533)
1997
41
Telomerase elevation in pancreatic ductal carcinoma compared to nonmalignant pathological states. (9815776)
1997
42
Differentiation of pancreatic ductal carcinoma cells associated with selective expression of protein kinase C isoforms. (8915489)
1996
43
Hematogenous metastases of pancreatic ductal carcinoma. (8532650)
1995
44
Comparative molecular field analysis of the antitumor activity of 9H-thioxanthen-9-one derivatives against pancreatic ductal carcinoma 03. (8145227)
1994
45
Comparison between a newly established pancreatic cystadenocarcinoma cell-line, ocup-1 and cells derived from pancreatic ductal carcinoma. (21567058)
1994
46
Interaction of pancreatic ductal carcinoma with nerves leads to nerve damage. (8020665)
1994
47
Sustained recovery from a solid type pancreatic ductal carcinoma originating in the pancreas tail: a case report. (8385066)
1993
48
Branch duct origin of solid type pancreatic ductal carcinoma. (8481143)
1993
49
Establishment of hamster pancreatic ductal carcinoma cell line (PC-1) producing blood group-related antigens. (2539915)
1989
50
Dilemma of pancreatic ductal carcinoma. (453140)
1979

Variations for Pancreatic Ductal Carcinoma

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Expression for genes affiliated with Pancreatic Ductal Carcinoma

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Search GEO for disease gene expression data for Pancreatic Ductal Carcinoma.

Pathways for genes affiliated with Pancreatic Ductal Carcinoma

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Pathways related to Pancreatic Ductal Carcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.8MUC6, MUC1, MUC2
2
Show member pathways
8.8MUC6, MUC1, MUC2

Compounds for genes affiliated with Pancreatic Ductal Carcinoma

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Compounds related to Pancreatic Ductal Carcinoma according to GeneCards Suite gene sharing:

(show all 35)
idCompoundScoreTop Affiliating Genes
1lead439.6NTS, TYMP
2nucleoside439.6NTS, TYMP
3hematoxylin439.6MUC2, MUC1
4galactose439.6MUC1, MUC2
5dtpa439.5MUC1, NTS
6inositol 1,4,5 trisphosphate439.5PFN1, NTS
7sulfate43 2410.5MUC1, MUC2
8polyethylene glycol439.5MUC1, NTS
9sialic acid439.4MUC2, MUC1
10carbohydrates439.4MUC1, MUC2
11agarose439.4MUC2, MUC1
12proline439.4PFN1, NTS, MUC2
13gemcitabine43 49 1211.3TYMP, MUC1
14prostacyclin439.3NTS, TYMP
15purine43 2410.3TYMP, MUC1
16formaldehyde43 2410.1MUC1, TYMP
17cholesterol43 28 24 1212.1MUC6, MUC2, MUC1
18forskolin43 49 1211.1NTS, MUC1, MUC2
19crcs439.0MUC1, MUC2, TYMP
20dexamethasone43 49 28 1212.0NTS, MUC1, MUC2
21methotrexate49 43 1211.0MUC2, TYMP, MUC1
2212-o-tetradecanoylphorbol 13-acetate439.0MUC1, MUC2, TYMP
23actinomycin d439.0MUC2, MUC1, TYMP
24folate438.9MUC1, TYMP
25thymidine43 249.9TYMP, MUC1, NTS
26atp43 289.8TYMP, PFN1, NTS
27nitric oxide43 24 1210.8MUC1, NTS, TYMP
285fluorouracil438.6MUC1, MUC6, MUC2, TYMP
29progesterone43 28 59 24 1212.6MUC6, MUC1, MUC2, TYMP
30estrogen438.6MUC1, MUC6, MUC2, TYMP
31calcium43 49 24 1211.5MUC6, MUC1, MUC2, NTS
32glucose438.5MUC1, MUC2, TYMP, NTS
33serine438.4NTS, MUC1, MUC2, TYMP
34cysteine438.3MUC1, MUC2, TYMP
35paraffin438.1TYMP, NTS, MUC6, MUC1, MUC2

GO Terms for genes affiliated with Pancreatic Ductal Carcinoma

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Cellular components related to Pancreatic Ductal Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057968.8MUC6, MUC1, MUC2

Biological processes related to Pancreatic Ductal Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1maintenance of gastrointestinal epitheliumGO:00302779.5MUC6, MUC2
2O-glycan processingGO:00162668.8MUC6, MUC1, MUC2
3cellular protein metabolic processGO:00442678.8MUC6, MUC1, MUC2
4post-translational protein modificationGO:00436878.5MUC2, MUC1, MUC6

Products for genes affiliated with Pancreatic Ductal Carcinoma

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Sources for Pancreatic Ductal Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet