MCID: PNC013
MIFTS: 46

Pancreatic Ductal Carcinoma malady

Cancer diseases, Endocrine diseases categories

Summaries for Pancreatic Ductal Carcinoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Pancreatic cancer is when cancer cells develop from the pancreas, a glandular organ located behind the... more...

MalaCards: Pancreatic Ductal Carcinoma, also known as malignant neoplasm of duct of wirsung, is related to cystadenocarcinoma and pancreatic cancer. An important gene associated with Pancreatic Ductal Carcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and O-linked glycosylation of mucins. The drugs gemcitabine and gemcitabine hydrochloride and the compounds lead and nucleoside have been mentioned in the context of this disorder. Affiliated tissues include pancreas, skin and endothelial, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Pancreatic Ductal Carcinoma

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9Disease Ontology, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreatic ductal carcinoma 9
malignant neoplasm of duct of wirsung 9
malignant neoplasm of pancreas 63
carcinoma, pancreatic ductal 63
carcinoma pancreatic ductal 46
pancreatic duct cancer 9


External Ids:

Disease Ontology9 DOID:3587
ICD9CM28 157.3
SNOMED-CT59 187793004, 93939009
ICD1026 C25, C25.3

Related Diseases for Pancreatic Ductal Carcinoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Pancreatic Ductal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1cystadenocarcinoma30.3MUC2, MUC1
2pancreatic cancer30.3NTS, MUC2
3adenoma30.2MUC2, MUC6, NTS, MUC1
4pancreatitis11.1
5endotheliitis10.3
6microcystic adenoma10.2
7pancreatic cystadenocarcinoma10.2
8hypoxia10.2
9biliary papillomatosis10.1MUC6, MUC2
10pseudomyxoma peritonei10.1MUC2, MUC6
11bronchiolo-alveolar adenocarcinoma10.1MUC2, MUC6
12barrett's esophagus10.1MUC2, MUC6
13microinvasive gastric cancer10.0TYMP, MUC2
14gallbladder cancer10.0MUC2, TYMP
15gastritis10.0MUC6, NTS
16allergic rhinitis10.0PFN1, MUC2
17familial adenomatous polyposis10.0MUC6, MUC2
18papillary adenocarcinoma10.0MUC1, MUC2
19tubular adenocarcinoma10.0MUC2, MUC1
20mucoepidermoid carcinoma10.0MUC1, MUC2
21bladder carcinoma10.0MUC2, TYMP
22gastric adenocarcinoma10.0MUC2, TYMP
23colon adenocarcinoma10.0MUC2, NTS
24papillary carcinoma10.0MUC2, MUC1
25pancreatitis, chronic10.0MUC6, MUC2, NTS
26cholangiocarcinoma10.0MUC2, MUC1
27cystic fibrosis10.0NTS, MUC6, MUC2
28endometrial carcinoma10.0MUC1, TYMP
29carcinoid syndrome10.0NTS, MUC1
30stomach cancer10.0MUC6, TYMP, MUC2
31cholera10.0NTS, MUC2
32non-small cell lung carcinoma10.0NTS, TYMP, MUC2
33colon cancer10.0TYMP, MUC2, NTS
34lung cancer10.0MUC2, NTS, TYMP
35adenosquamous carcinoma10.0MUC2, TYMP, MUC1
36meningioma10.0NTS, MUC1
37ovarian cancer10.0MUC1, MUC2, TYMP
38colorectal cancer9.9NTS, MUC6, TYMP, MUC2
39breast cancer9.9TYMP, MUC1, MUC6, MUC2
40tongue squamous cell carcinoma9.9MUC6, MUC1, TYMP, MUC2
41adenocarcinoma9.9MUC2, MUC6, NTS, TYMP, MUC1

Graphical network of the top 20 diseases related to Pancreatic Ductal Carcinoma:



Diseases related to pancreatic ductal carcinoma

Symptoms for Pancreatic Ductal Carcinoma

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Drugs & Therapeutics for Pancreatic Ductal Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Pancreatic Ductal Carcinoma

Drug clinical trials:

Search ClinicalTrials for Pancreatic Ductal Carcinoma

Search NIH Clinical Center for Pancreatic Ductal Carcinoma

Search CenterWatch for Pancreatic Ductal Carcinoma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Pancreatic Ductal Carcinoma

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Anatomical Context for Pancreatic Ductal Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Pancreatic Ductal Carcinoma:

34
Pancreas, Skin, Endothelial, Bone, Bone marrow

Animal Models for Pancreatic Ductal Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pancreatic Ductal Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6NTS, MUC1, MUC2, PFN1, TYMP

Publications for Pancreatic Ductal Carcinoma

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53PubMed
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Articles related to Pancreatic Ductal Carcinoma:

(show top 50)    (show all 67)
idTitleAuthorsYear
1
Pancreatic intraglandular metastasis predicts poorer outcome in postoperative patients with pancreatic ductal carcinoma. (23648465)
2013
2
Preoperative platelet-lymphocyte ratio in resected pancreatic ductal carcinoma: is it meaningful? (20579970)
2012
3
Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue. (22892044)
2012
4
Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model. (22190076)
2012
5
Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma. (21841817)
2012
6
Clinicopathologic assessment of pancreatic ductal carcinoma located at the head of the pancreas, in relation to embryonic development. (22228049)
2012
7
Expression of KL-6/MUC1 in pancreatic ductal carcinoma and its potential relationship with I^-catenin in tumor progression. (21466814)
2011
8
Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-1 and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1. (21272935)
2011
9
Cytologic features of pancreatic intraepithelial neoplasia and pancreatitis: potential pitfalls in the diagnosis of pancreatic ductal carcinoma. (20730891)
2011
10
KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma. (21224073)
2011
11
Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology. (19856421)
2010
12
Expression of EGF and EGFR strongly correlates with metastasis of pancreatic ductal carcinoma. (18505086)
2008
13
Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma. (19020717)
2008
14
Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy. (17072983)
2006
15
Pancreatic ductal carcinoma: from the bench to the bedside. (16998251)
2006
16
Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma. (15985168)
2005
17
Factors predicting recurrence after resection of pancreatic ductal carcinoma. (15968250)
2005
18
Evaluation of vascular signal in pancreatic ductal carcinoma using contrast enhanced ultrasonography: effect of systemic chemotherapy. (15951559)
2005
19
Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A. (16335935)
2005
20
Experimental trial for diagnosis of pancreatic ductal carcinoma based on gene expression profiles of pancreatic ductal cells. (16053509)
2005
21
Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta. (14973050)
2004
22
A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile. (15258755)
2004
23
Evaluation of blood flow in pancreatic ductal carcinoma using contrast-enhanced, wide-band Doppler ultrasonography: correlation with tumor characteristics and vascular endothelial growth factor. (15084983)
2004
24
Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays. (15548371)
2004
25
A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform. (12692724)
2003
26
Expressions of angiogenic factors in pancreatic ductal carcinoma: a correlative study with clinicopathologic parameters and patient survival. (12717266)
2003
27
Expression of transcription factor E2F-1 in pancreatic ductal carcinoma: an immunohistochemical study. (12650514)
2003
28
Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinoma. (12824920)
2003
29
MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration. (14681945)
2003
30
Proteomic analysis of pancreatic ductal carcinoma cells treated with 5-aza-2'-deoxycytidine. (14679576)
2003
31
Vascular endothelial growth factor mediated angiogenic potential of pancreatic ductal carcinomas enhanced by hypoxia: an in vitro and in vivo study. (12448000)
2002
32
The molecular genetics of pancreatic ductal carcinoma. (12370658)
2002
33
Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. (12429967)
2002
34
Endocrine and intermediate cells in pancreatic ductal carcinoma and in chronic pancreatitis. (12533945)
2002
35
Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. (11238189)
2001
36
Heterogeneic distribution of thymidine phosphorylase between primary tumors and metastatic lesions of human pancreatic ductal carcinoma: implications for the efficacy of chemotherapy with 5-FU or its derivatives. (11391857)
2001
37
A case of small pancreatic ductal carcinoma accompanied by intraductal mucin-producing pancreatic tumors. (10824701)
2000
38
Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation. (9477096)
1998
39
Ki-ras and p53 gene mutations in pancreatic ductal carcinoma: a relationship with tumor phenotype and survival. (10076772)
1998
40
Isolation of a pancreas-specific gene located on human chromosome 14q31: expression analysis in human pancreatic ductal carcinomas. (9417916)
1997
41
p53 protein overexpression and K-ras codon 12 mutation in pancreatic ductal carcinoma: correlation with histologic factors. (9293533)
1997
42
Telomerase elevation in pancreatic ductal carcinoma compared to nonmalignant pathological states. (9815776)
1997
43
Differentiation of pancreatic ductal carcinoma cells associated with selective expression of protein kinase C isoforms. (8915489)
1996
44
Hematogenous metastases of pancreatic ductal carcinoma. (8532650)
1995
45
Comparison between a newly established pancreatic cystadenocarcinoma cell-line, ocup-1 and cells derived from pancreatic ductal carcinoma. (21567058)
1994
46
Interaction of pancreatic ductal carcinoma with nerves leads to nerve damage. (8020665)
1994
47
Sustained recovery from a solid type pancreatic ductal carcinoma originating in the pancreas tail: a case report. (8385066)
1993
48
Branch duct origin of solid type pancreatic ductal carcinoma. (8481143)
1993
49
Establishment of hamster pancreatic ductal carcinoma cell line (PC-1) producing blood group-related antigens. (2539915)
1989
50
Dilemma of pancreatic ductal carcinoma. (453140)
1979

Variations for Pancreatic Ductal Carcinoma

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Pancreatic Ductal Carcinoma:

1
id Gene Name Type Significance SNP ID Assembly Location
1SMAD4NM_005359.5(SMAD4): c.1236C> G (p.Tyr412Ter)single nucleotide variantPathogenicrs121912577GRCh37Chr 18, 48593485: 48593485

Expression for genes affiliated with Pancreatic Ductal Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Ductal Carcinoma

Search GEO for disease gene expression data for Pancreatic Ductal Carcinoma.

Pathways for genes affiliated with Pancreatic Ductal Carcinoma

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG
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Compounds for genes affiliated with Pancreatic Ductal Carcinoma

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46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1lead469.6NTS, TYMP
2nucleoside469.6TYMP, NTS
3hematoxylin469.6MUC2, MUC1
4galactose469.6MUC1, MUC2
5dtpa469.5MUC1, NTS
6inositol 1,4,5 trisphosphate469.5PFN1, NTS
7sulfate46 2510.5MUC1, MUC2
8polyethylene glycol469.5MUC1, NTS
9sialic acid469.4MUC1, MUC2
10agarose469.4MUC2, MUC1
11carbohydrates469.4MUC2, MUC1
12proline469.4NTS, MUC2, PFN1
13gemcitabine46 52 1211.3MUC1, TYMP
14prostacyclin469.3NTS, TYMP
15purine46 2510.3MUC1, TYMP
16formaldehyde46 2510.1MUC1, TYMP
17cholesterol46 30 25 1212.1MUC6, MUC1, MUC2
18forskolin46 52 1211.1MUC2, MUC1, NTS
19crcs469.0MUC1, MUC2, TYMP
20dexamethasone46 52 30 1212.0MUC2, MUC1, NTS
21methotrexate52 46 1211.0MUC1, MUC2, TYMP
2212-o-tetradecanoylphorbol 13-acetate469.0MUC1, MUC2, TYMP
23actinomycin d469.0MUC1, MUC2, TYMP
24folate468.9TYMP, MUC1
25thymidine46 259.9TYMP, MUC1, NTS
26atp46 309.8NTS, PFN1, TYMP
27nitric oxide46 25 1210.8NTS, MUC1, TYMP
285fluorouracil468.6TYMP, MUC2, MUC1, MUC6
29progesterone46 30 62 25 1212.6TYMP, MUC2, MUC1, MUC6
30estrogen468.6TYMP, MUC2, MUC1, MUC6
31calcium46 52 25 1211.5MUC2, MUC1, MUC6, NTS
32glucose468.5TYMP, MUC2, MUC1, NTS
33serine468.4NTS, MUC1, MUC2, TYMP
34cysteine468.3MUC1, MUC2, TYMP
35paraffin468.1NTS, MUC6, MUC1, MUC2, TYMP

GO Terms for genes affiliated with Pancreatic Ductal Carcinoma

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17Gene Ontology
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Cellular components related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057968.8MUC6, MUC1, MUC2

Biological processes related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1maintenance of gastrointestinal epitheliumGO:0302779.5MUC6, MUC2
2O-glycan processingGO:0162668.8MUC6, MUC1, MUC2
3cellular protein metabolic processGO:0442678.8MUC6, MUC1, MUC2
4post-translational protein modificationGO:0436878.5MUC2, MUC1, MUC6

Products for genes affiliated with Pancreatic Ductal Carcinoma

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Sources for Pancreatic Ductal Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet