MCID: PNC013
MIFTS: 52

Pancreatic Ductal Carcinoma malady

Cancer diseases, Endocrine diseases categories

Summaries for Pancreatic Ductal Carcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues forming... more...

MalaCards: Pancreatic Ductal Carcinoma, also known as malignant neoplasm of duct of wirsung, is related to pancreatic cancer and cystadenocarcinoma. An important gene associated with Pancreatic Ductal Carcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are O-linked glycosylation of mucins and Cytoskeletal Signaling. The drugs gemcitabine and gemcitabine hydrochloride and the compounds estrogen and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include pancreas, endothelial and bone marrow, and related mouse phenotypes are homeostasis/metabolism and normal.

Aliases & Classifications for Pancreatic Ductal Carcinoma

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreatic ductal carcinoma 8
malignant neoplasm of duct of wirsung 8
malignant neoplasm of pancreas 60
carcinoma, pancreatic ductal 60
carcinoma pancreatic ductal 44
pancreatic duct cancer 8


External Ids:

Disease Ontology8 DOID:3587
ICD9CM27 157.3
SNOMED-CT56 187793004, 93939009
ICD1025 C25, C25.3

Related Diseases for Pancreatic Ductal Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Pancreatic Ductal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cancer30.4MUC2, MUC6, MUC5AC, MUC1, CDK2, THBS1
2cystadenocarcinoma30.2MUC2, MUC5AC, MUC1
3adenoma30.2MUC5AC, MUC6, MUC2, NTS, MUC1, CDK2
4pancreatitis11.1
5bone carcinoma10.1
6pancreatic endocrine carcinoma10.1
7microcystic adenoma10.1
8pancreatic cystadenocarcinoma10.1
9pancreas sarcoma10.1
10pancreatoblastoma10.1
11pancreatic cancer, childhood10.1
12pancreatic cancer 110.1
13pancreatic carcinoma, somatic10.1
14pancreatic cancer 310.1
15ampulla of vater neoplasm10.0MUC2
16endometriosis10.0TYMP
17esophagitis10.0NTS
18ulcerative colitis10.0SEL1L
19inflammatory bowel disease10.0MUC2
20cystadenoma10.0KRT7
21asbestosis10.0MSLN
22pituitary adenoma10.0NTS
23gallbladder cancer10.0MUC2
24hepatitis10.0TYMP
25angiosarcoma10.0MUC1
26teratoma10.0KRT7
27sertoli cell tumor10.0MUC1
28ependymoma10.0MUC1
29malignant pleural mesothelioma10.0MSLN
30biliary papillomatosis10.0MUC6, MUC2
31otitis media10.0MUC5AC
32adenomatoid tumor10.0WT1
33renal oncocytoma10.0KRT7
34allergic rhinitis10.0PFN1, MUC2
35meningioma10.0MUC1, NTS
36cervical intraepithelial neoplasia10.0CDK2
37myeloma10.0CDK2
38thymus cancer10.0KRT7, MUC1
39secretory meningioma10.0MUC1, KRT7
40leiomyoma10.0CDK2, TYMP
41renal clear cell carcinoma10.0KRT7, MUC1
42nephrogenic adenoma10.0KRT7
43herpes simplex10.0THBS1
44bladder adenocarcinoma10.0KRT20, KRT7
45rectal neoplasm10.0TYMP, KRT20, CEACAM7
46metanephric adenoma10.0KRT7, WT1
47papillary adenocarcinoma10.0MUC1, MUC2
48signet ring cell adenocarcinoma10.0MUC2, KRT7, KRT20
49papilloma10.0MUC2, MUC5AC
50ovarian brenner tumor10.0KRT7, KRT20

Graphical network of the top 20 diseases related to Pancreatic Ductal Carcinoma:



Diseases related to pancreatic ductal carcinoma

Clinical Features for Pancreatic Ductal Carcinoma

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Drugs & Therapeutics for Pancreatic Ductal Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pancreatic Ductal Carcinoma

Drug clinical trials:

Search ClinicalTrials for Pancreatic Ductal Carcinoma

Search NIH Clinical Center for Pancreatic Ductal Carcinoma

Search CenterWatch for Pancreatic Ductal Carcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pancreatic Ductal Carcinoma

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Anatomical Context for Pancreatic Ductal Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Pancreatic Ductal Carcinoma:

32
Pancreas, Endothelial, Bone marrow, Bone

Animal Models for Pancreatic Ductal Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pancreatic Ductal Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.4STMN1, NTSR1, NTS, MUC2, MUC5AC, PFN1
2MP:00028739.3STMN1, NTSR1, DNM2, MUC1, PFN1, MSLN
3MP:00053848.6SEL1L, PDIA3, WT1, TYMP, DNM2, MUC2
4MP:00053788.5PDIA3, WT1, NTSR1, NTS, DNM2, MUC2

Publications for Pancreatic Ductal Carcinoma

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Sources:
50PubMed
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Articles related to Pancreatic Ductal Carcinoma:

(show top 50)    (show all 91)
idTitleAuthorsYear
1
Disease spectrum of intraductal papillary mucinous neoplasm with an associated invasive carcinoma invasive IPMN versus pancreatic ductal adenocarcinoma-associated IPMN. (24308063)
2013
2
Preoperative platelet-lymphocyte ratio in resected pancreatic ductal carcinoma: is it meaningful? (20579970)
2012
3
Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue. (22892044)
2012
4
Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model. (22190076)
2012
5
Cystic papillary pattern in pancreatic ductal adenocarcinoma: a heretofore undescribed morphologic pattern that mimics intraductal papillary mucinous carcinoma. (22367300)
2012
6
Clinicopathologic assessment of pancreatic ductal carcinoma located at the head of the pancreas, in relation to embryonic development. (22228049)
2012
7
Histologic grading of the extent of residual carcinoma following neoadjuvant chemoradiation in pancreatic ductal adenocarcinoma: a predictor for patient outcome. (22028089)
2012
8
Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-1 and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1. (21272935)
2011
9
Cytologic features of pancreatic intraepithelial neoplasia and pancreatitis: potential pitfalls in the diagnosis of pancreatic ductal carcinoma. (20730891)
2011
10
KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma. (21224073)
2011
11
Invasive carcinoma arising in intraductal papillary mucinous neoplasms of the pancreas: a matched control study with conventional pancreatic ductal adenocarcinoma. (21422912)
2011
12
Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology. (19856421)
2010
13
Correlations between p53 gene mutations and histologic characteristics of pancreatic ductal carcinoma. (19248224)
2009
14
Does contrast-enhanced ultrasound reveal tumor angiogenesis in pancreatic ductal carcinoma? A prospective study. (18845377)
2009
15
Expression of EGF and EGFR strongly correlates with metastasis of pancreatic ductal carcinoma. (18505086)
2008
16
Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy. (17072983)
2006
17
Pancreatic ductal carcinoma: from the bench to the bedside. (16998251)
2006
18
Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma. (15985168)
2005
19
Evaluation of vascular signal in pancreatic ductal carcinoma using contrast enhanced ultrasonography: effect of systemic chemotherapy. (15951559)
2005
20
Experimental trial for diagnosis of pancreatic ductal carcinoma based on gene expression profiles of pancreatic ductal cells. (16053509)
2005
21
Detection of tumor cell dissemination in pancreatic ductal carcinoma patients by CK 20 RT-PCR indicates poor survival. (16136352)
2005
22
Retroviral expression screening of oncogenes in pancreatic ductal carcinoma. (16125925)
2005
23
A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile. (15258755)
2004
24
Evaluation of blood flow in pancreatic ductal carcinoma using contrast-enhanced, wide-band Doppler ultrasonography: correlation with tumor characteristics and vascular endothelial growth factor. (15084983)
2004
25
Cdx2 expression in pancreatic tumors: Relationship with prognosis of invasive ductal carcinomas. (15547744)
2004
26
Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives. (14745573)
2004
27
Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines. (15084985)
2004
28
Expression of transcription factor E2F-1 in pancreatic ductal carcinoma: an immunohistochemical study. (12650514)
2003
29
Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinoma. (12824920)
2003
30
Proteomic analysis of pancreatic ductal carcinoma cells treated with 5-aza-2'-deoxycytidine. (14679576)
2003
31
Vascular endothelial growth factor mediated angiogenic potential of pancreatic ductal carcinomas enhanced by hypoxia: an in vitro and in vivo study. (12448000)
2002
32
Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. (12429967)
2002
33
Endocrine and intermediate cells in pancreatic ductal carcinoma and in chronic pancreatitis. (12533945)
2002
34
Mixed ductal-pancreatic polypeptide-cell carcinoma of the pancreas. (12147089)
2002
35
Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. (11238189)
2001
36
Heterogeneic distribution of thymidine phosphorylase between primary tumors and metastatic lesions of human pancreatic ductal carcinoma: implications for the efficacy of chemotherapy with 5-FU or its derivatives. (11391857)
2001
37
Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma. (11562741)
2001
38
The grade of pancreatic ductal carcinoma is an independent prognostic factor and is superior to the immunohistochemical assessment of proliferation. (10861575)
2000
39
Expression of CD44 and isoforms v4, v5, v6, v7, v10--new prognostic parameters in ductal pancreatic carcinoma?]. (9833191)
1998
40
Isolation of a pancreas-specific gene located on human chromosome 14q31: expression analysis in human pancreatic ductal carcinomas. (9417916)
1997
41
p53 protein overexpression and K-ras codon 12 mutation in pancreatic ductal carcinoma: correlation with histologic factors. (9293533)
1997
42
Telomerase elevation in pancreatic ductal carcinoma compared to nonmalignant pathological states. (9815776)
1997
43
Differentiation of pancreatic ductal carcinoma cells associated with selective expression of protein kinase C isoforms. (8915489)
1996
44
Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines. (8599583)
1996
45
Hematogenous metastases of pancreatic ductal carcinoma. (8532650)
1995
46
Comparative molecular field analysis of the antitumor activity of 9H-thioxanthen-9-one derivatives against pancreatic ductal carcinoma 03. (8145227)
1994
47
Comparison between a newly established pancreatic cystadenocarcinoma cell-line, ocup-1 and cells derived from pancreatic ductal carcinoma. (21567058)
1994
48
Sustained recovery from a solid type pancreatic ductal carcinoma originating in the pancreas tail: a case report. (8385066)
1993
49
Pancreatic microcystic adenoma coexistent with pancreatic ductal carcinoma. A report of two cases. (2157344)
1990
50
Early lesions of pancreatic ductal carcinoma in the hamster model. (195472)
1977

Genetic Variations for Pancreatic Ductal Carcinoma

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Expression for genes affiliated with Pancreatic Ductal Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Ductal Carcinoma

Search GEO for disease gene expression data for Pancreatic Ductal Carcinoma.

Pathways for genes affiliated with Pancreatic Ductal Carcinoma

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53Reactome, 4Cell Signaling Technology, 37NCBI BioSystems Database
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Pathways related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9MUC1, MUC5AC, MUC6, MUC2
29.8STMN1, DNM2, PFN1, KRT7
3
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9.8MUC1, MUC5AC, MUC2, PDIA3
49.8WT1, STMN1, CDK2, THBS1

Compounds for genes affiliated with Pancreatic Ductal Carcinoma

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CEACAM7
2sialic acid4410.6KRT7
3hematoxylin4410.5KRT20, KRT7
4sr142948a44 2811.5NTSR1, NTS
5neurotensin59 2811.4NTSR1, NTS
6xenin 85910.4NTS, NTSR1
7sr 486925910.4NTS, NTSR1
8sr 1429485910.4NTSR1, NTS
9sr4869244 2811.4NTSR1, NTS
10butyrate4410.4CEACAM7, CDK2
11jmv 4495910.4NTSR1, NTS
12carbohydrates4410.3MUC2, MUC5AC
13crcs4410.3TYMP, MUC2, MUC1
14mucicarmine4410.2MUC1, KRT7, CEACAM7, KRT20
15levocabastine44 28 1112.1NTS, NTSR1
16hyaluronic acid44 2411.1WT1, MSLN, KRT20, THBS1, MUC1
1712-o-tetradecanoylphorbol 13-acetate4410.0THBS1, MUC1, MUC2, STMN1, TYMP, WT1
18methotrexate44 49 1112.0KRT7, MUC5AC, MUC1, MUC2, TYMP
19dmso4410.0MUC5AC, MUC1, CDK2, THBS1, MUC2
20ribonucleic acid4410.0THBS1, MUC5AC, WT1, KRT20, MUC1
21formaldehyde44 2410.9MUC1, KRT20, KRT7, TYMP
22proline449.9DNM2, MUC5AC, WT1, PFN1, NTS, MUC2
23prostaglandin449.9THBS1, MUC5AC, NTS
24doxorubicin44 49 1111.9THBS1, STMN1, CDK2, KRT20, TYMP, WT1
25pd 98,059449.9STMN1, NTS, CDK2, MUC2, THBS1, MUC5AC
26b 723449.8WT1, MUC1, KRT7, KRT20, MSLN, CEACAM7
27actinomycin d449.8TYMP, MUC2, CDK2, CEACAM7, MUC1
28forskolin44 49 1111.8MUC2, NTS, STMN1, WT1, MUC1
29polysaccharide449.8PDIA3, MUC1, THBS1, KRT7, MUC5AC, MUC6
30phosphoinositide449.8NTS, CDK2, PFN1, THBS1, DNM2
31dexamethasone44 49 28 1112.8MUC5AC, CDK2, MUC2, NTS
32oligonucleotide449.7THBS1, WT1, STMN1, MUC2, MSLN, MUC5AC
33cholesterol44 28 11 2412.7CDK2, MUC2, THBS1, DNM2, MUC1, MUC5AC
34threonine449.6WT1, MUC2, MUC5AC, MUC1, THBS1, STMN1
35atp44 2810.6PDIA3, STMN1, TYMP, MUC5AC, PFN1, CDK2
365fluorouracil449.6CEACAM7, CDK2, TYMP, MUC2, MUC5AC, MUC1
37cysteine449.6MUC5AC, MUC1, TYMP, WT1, MUC2, THBS1
38nitric oxide44 11 2411.5DNM2, TYMP, NTS, THBS1, CDK2, MUC1
39vegf449.5THBS1, TYMP, WT1, KRT7, KRT20, MSLN
40testosterone44 59 11 2412.4CDK2, KRT20, KRT7, THBS1, WT1, NTS
41lipid449.4PFN1, CDK2, MUC1, DNM2, NTS, NTSR1
42thymidine44 2410.4CEACAM7, NTS, THBS1, CDK2, MUC1, TYMP
43serine449.4STMN1, NTS, MUC5AC, THBS1, CDK2, MUC1
44glucose449.3KRT7, NTS, TYMP, MUC2, MUC5AC, MUC1
45paraffin449.3TYMP, WT1, NTS, MUC2, KRT20, KRT7
46retinoic acid44 2410.3MUC1, STMN1, MUC2, MUC5AC, CDK2, THBS1
47calcium44 49 11 2412.1NTSR1, THBS1, CDK2, MUC6, MUC2, NTS
48phosphatidylinositol449.1DNM2, NTS, THBS1, MUC5AC, CDK2, PDIA3
49progesterone44 59 28 11 2412.9MUC6, MUC2, KRT20, KRT7, CEACAM7, THBS1
50tyrosine448.6MCM7, CDK2, THBS1, MUC1, MUC5AC, DNM2

GO Terms for genes affiliated with Pancreatic Ductal Carcinoma

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16Gene Ontology
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Cellular components related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.9MUC1, MUC5AC, MUC6, MUC2

Biological processes related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1O-glycan processingGO:0162669.8MUC1, MUC5AC, MUC6, MUC2
2cellular protein metabolic processGO:0442679.6MUC1, MUC5AC, MUC6, MUC2, PDIA3
3post-translational protein modificationGO:0436879.3PDIA3, MUC2, MUC6, MUC5AC, MUC1

Molecular functions related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.9SEL1L, WT1, NTSR1, NTS, DNM2, MUC2

Products for genes affiliated with Pancreatic Ductal Carcinoma

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  • Antibodies
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Sources for Pancreatic Ductal Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet