MCID: PNC013
MIFTS: 46

Pancreatic Ductal Carcinoma malady

Cancer, Endocrine categories

Summaries for Pancreatic Ductal Carcinoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues forming... more...

MalaCards: Pancreatic Ductal Carcinoma, also known as malignant neoplasm of duct of wirsung, is related to pancreatitis, chronic and adenoma. An important gene associated with Pancreatic Ductal Carcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are O-linked glycosylation of mucins and Cytoskeletal Signaling. The drugs gemcitabine and gemcitabine hydrochloride and the compounds estrogen and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, pancreas and endothelial, and related mouse phenotypes are homeostasis/metabolism and normal.

Aliases & Classifications for Pancreatic Ductal Carcinoma

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Endocrine


Aliases & Descriptions:

pancreatic ductal carcinoma 8
malignant neoplasm of duct of wirsung 8
malignant neoplasm of pancreas 61
carcinoma, pancreatic ductal 61
carcinoma pancreatic ductal 45
pancreatic duct cancer 8


External Ids:

Disease Ontology8 DOID:3587
ICD9CM27 157.3
SNOMED-CT57 187793004, 93939009
ICD1025 C25, C25.3

Related Diseases for Pancreatic Ductal Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pancreatic Ductal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis, chronic30.2MUC6, NTS, MUC5AC, MSLN, MUC2
2adenoma30.2CEACAM7, KRT20, KRT7, THBS1, CDK2, MUC1
3pancreas sarcoma10.2
4pancreatic cancer, childhood10.2
5pancreatic cancer 110.2
6pancreatic carcinoma, somatic10.2
7pancreatic cancer 310.2
8bone carcinoma10.2
9pancreatic endocrine carcinoma10.2
10microcystic adenoma10.2
11pancreatic adenoma10.2
12hypoxia10.2
13pancreatic cancer 410.2
14ampulla of vater carcinoma10.0MUC2
15endometriosis10.0TYMP
16esophagitis10.0NTS
17ulcerative colitis10.0SEL1L
18inflammatory bowel disease10.0MUC2
19cystadenoma10.0KRT7
20asbestosis10.0MSLN
21pituitary adenoma10.0NTS
22gallbladder cancer10.0MUC2
23hepatitis10.0TYMP
24angiosarcoma10.0MUC1
25teratoma10.0KRT7
26sertoli cell tumor10.0MUC1
27ependymoma10.0MUC1
28malignant pleural mesothelioma10.0MSLN
29biliary papillomatosis10.0MUC6, MUC2
30otitis media10.0MUC5AC
31adenomatoid tumor10.0WT1
32renal oncocytoma10.0KRT7
33allergic rhinitis10.0PFN1, MUC2
34meningioma10.0MUC1, NTS
35cervical intraepithelial neoplasia10.0CDK2
36myeloma10.0CDK2
37thymic carcinoma10.0MUC1, KRT7
38secretory meningioma10.0KRT7, MUC1
39leiomyoma10.0TYMP, CDK2
40renal clear cell carcinoma10.0KRT7, MUC1
41cystadenocarcinoma10.0MUC5AC, MUC1, MUC2
42herpes simplex10.0THBS1
43bladder adenocarcinoma10.0KRT7, KRT20
44rectum cancer10.0CEACAM7, KRT20, TYMP
45nephrogenic adenoma10.0KRT7
46metanephric adenoma10.0WT1, KRT7
47papillary adenocarcinoma10.0MUC2, MUC1
48signet ring cell adenocarcinoma10.0MUC2, KRT7, KRT20
49papilloma10.0MUC2, MUC5AC
50neuroblastoma10.0NTS

Graphical network of the top 20 diseases related to Pancreatic Ductal Carcinoma:



Diseases related to pancreatic ductal carcinoma

Clinical Features for Pancreatic Ductal Carcinoma

Drugs & Therapeutics for Pancreatic Ductal Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pancreatic Ductal Carcinoma

Drug clinical trials:

Search ClinicalTrials for Pancreatic Ductal Carcinoma

Search NIH Clinical Center for Pancreatic Ductal Carcinoma

Search CenterWatch for Pancreatic Ductal Carcinoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Pancreatic Ductal Carcinoma

Anatomical Context for Pancreatic Ductal Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Pancreatic Ductal Carcinoma:

33
Bone marrow, Pancreas, Endothelial, Pancreatic islet

Animal Models for Pancreatic Ductal Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pancreatic Ductal Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.4PFN1, MUC5AC, MUC2, NTS, NTSR1, STMN1
2MP:00028739.3STMN1, NTSR1, DNM2, MUC1, PFN1, MSLN
3MP:00053848.6DNM2, CDK2, PFN1, MCM7, THBS1, KRT7
4MP:00053788.5THBS1, PDIA3, MCM7, PFN1, CDK2, MUC2

Publications for Pancreatic Ductal Carcinoma

Sources:
51PubMed
See all sources

Articles related to Pancreatic Ductal Carcinoma:

(show top 50)    (show all 93)
idTitleAuthorsYear
1
Pancreatic intraglandular metastasis predicts poorer outcome in postoperative patients with pancreatic ductal carcinoma. (23648465)
2013
2
Bile duct carcinoma involving the common channel associated with pancreaticobiliary maljunction shows an extension pattern similar to ductal carcinoma of the pancreas. (23957917)
2013
3
Differential ezrin and phosphorylated ezrin expression profiles between pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and invasive ductal carcinoma of the pancreas. (23465281)
2013
4
Metachronous pancreatic head ductal carcinoma three years after resection of gallbladder cancer. (24179579)
2013
5
Disease spectrum of intraductal papillary mucinous neoplasm with an associated invasive carcinoma invasive IPMN versus pancreatic ductal adenocarcinoma-associated IPMN. (24308063)
2013
6
Pancreatic metastases of renal clear cell carcinoma: a clinicopathological study of 11 cases with special emphasis on the usefulness of PAX2 and mesothelin for the distinction from primary ductal adenocarcinoma of the pancreas. (24344503)
2013
7
Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma. (21841817)
2012
8
Assessment of the interface between retroperitoneal fat infiltration of pancreatic ductal carcinoma and the major artery by multidetector-row computed tomography: surgical outcomes and correlation with histopathological extension. (22562451)
2012
9
Expression of KL-6/MUC1 in pancreatic ductal carcinoma and its potential relationship with I^-catenin in tumor progression. (21466814)
2011
10
Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-1 and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1. (21272935)
2011
11
KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma. (21224073)
2011
12
Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas. (20838624)
2010
13
Pancreatic acinar cell carcinomas with prominent ductal differentiation: Mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma. (20182344)
2010
14
Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma. (19270646)
2009
15
Amplification of the urokinase-type plasminogen activator receptor (uPAR) gene in ductal pancreatic carcinomas identifies a clinically high-risk group. (19435784)
2009
16
Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma. (19020717)
2008
17
Mixed ductal-endocrine carcinoma of the pancreas with synchronous papillary carcinoma-in-situ of the common bile duct: a case report and literature review--synchronous pancreatic and bile duct tumors. (18453301)
2008
18
The expression of matrix metalloproteinases-2 and -9 and their tissue inhibitor 2 in pancreatic ductal and ampullary carcinoma and their relation to angiogenesis and clinicopathological parameters. (18630474)
2008
19
Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation. (17378244)
2007
20
Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy. (17072983)
2006
21
Reappraisal of the clinical significance of tumor size in patients with pancreatic ductal carcinoma. (17003643)
2006
22
Factors predicting recurrence after resection of pancreatic ductal carcinoma. (15968250)
2005
23
Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A. (16335935)
2005
24
Intercalated duct cell is starting point in development of pancreatic ductal carcinoma? (16018800)
2005
25
Retroviral expression screening of oncogenes in pancreatic ductal carcinoma. (16125925)
2005
26
Amplification and overexpression of HER-2/neu in invasive ductal carcinomas of the pancreas and pancreatic intraepithelial neoplasms and the relationship to the expression of p21(WAF1/CIP1). (15190415)
2004
27
Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta. (14973050)
2004
28
A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile. (15258755)
2004
29
Evaluation of blood flow in pancreatic ductal carcinoma using contrast-enhanced, wide-band Doppler ultrasonography: correlation with tumor characteristics and vascular endothelial growth factor. (15084983)
2004
30
Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays. (15548371)
2004
31
Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives. (14745573)
2004
32
Terminally modified oligodeoxynucleotides directed against p53 in an orthotopic xenograft model: a novel adjuvant treatment strategy for pancreatic ductal carcinoma. (14707723)
2004
33
A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform. (12692724)
2003
34
Expressions of angiogenic factors in pancreatic ductal carcinoma: a correlative study with clinicopathologic parameters and patient survival. (12717266)
2003
35
Expression of transcription factor E2F-1 in pancreatic ductal carcinoma: an immunohistochemical study. (12650514)
2003
36
MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration. (14681945)
2003
37
Proteomic profiling of pancreatic ductal carcinoma cell lines treated with trichostatin-A. (12783462)
2003
38
The molecular genetics of pancreatic ductal carcinoma. (12370658)
2002
39
Phenotypical characteristics of undifferentiated carcinoma of the pancreas: a comparison with pancreatic ductal adenocarcinoma and relevance of E-cadherin, alpha catenin and beta catenin expression. (11410776)
2001
40
A case of small pancreatic ductal carcinoma accompanied by intraductal mucin-producing pancreatic tumors. (10824701)
2000
41
The molecular genetics of pancreatic ductal carcinoma: a review. (11356337)
2000
42
Centrosome abnormalities in pancreatic ductal carcinoma. (10353727)
1999
43
Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation. (9477096)
1998
44
Ki-ras and p53 gene mutations in pancreatic ductal carcinoma: a relationship with tumor phenotype and survival. (10076772)
1998
45
Chemopreventive activity of Oltipraz against N-nitrosobis(2-oxopropyl)amine (BOP)-induced ductal pancreatic carcinoma development and effects on survival of Syrian golden hamsters. (7554069)
1995
46
Interaction of pancreatic ductal carcinoma with nerves leads to nerve damage. (8020665)
1994
47
Intermediate filaments in rat pancreatic acinar tumors, human ductal carcinomas, and other gastrointestinal malignancies. (7513668)
1994
48
Branch duct origin of solid type pancreatic ductal carcinoma. (8481143)
1993
49
Establishment of hamster pancreatic ductal carcinoma cell line (PC-1) producing blood group-related antigens. (2539915)
1989
50
Dilemma of pancreatic ductal carcinoma. (453140)
1979

Genetic Variations for Pancreatic Ductal Carcinoma

Expression for genes affiliated with Pancreatic Ductal Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pancreatic Ductal Carcinoma

Search GEO for disease gene expression data for Pancreatic Ductal Carcinoma.

Pathways for genes affiliated with Pancreatic Ductal Carcinoma

Sources:
54Reactome, 4Cell Signaling Technology, 38NCBI BioSystems Database
See all sources

Pathways related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9MUC1, MUC5AC, MUC6, MUC2
29.8STMN1, DNM2, PFN1, KRT7
3
Hide members
9.8MUC1, MUC5AC, MUC2, PDIA3
49.8WT1, STMN1, CDK2, THBS1

Compounds for genes affiliated with Pancreatic Ductal Carcinoma

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7CEACAM7
2sialic acid4510.6KRT7
3hematoxylin4510.5KRT20, KRT7
4sr142948a45 2911.5NTSR1, NTS
5xenin 86010.4NTSR1, NTS
6neurotensin60 2911.4NTSR1, NTS
7jmv 4496010.4NTSR1, NTS
8sr 486926010.4NTSR1, NTS
9sr 1429486010.4NTSR1, NTS
10butyrate4510.4CEACAM7, CDK2
11sr4869245 2911.4NTSR1, NTS
12carbohydrates4510.3MUC5AC, MUC2
13crcs4510.3TYMP, MUC2, MUC1
14mucicarmine4510.2MUC1, KRT7, KRT20, CEACAM7
15levocabastine45 29 1112.1NTS, NTSR1
16hyaluronic acid45 2411.1WT1, MUC1, THBS1, KRT20, MSLN
1712-o-tetradecanoylphorbol 13-acetate4510.0WT1, STMN1, TYMP, MUC2, MUC1, THBS1
18methotrexate45 50 1112.0TYMP, MUC2, MUC5AC, MUC1, KRT7
19dmso4510.0MUC2, MUC5AC, MUC1, CDK2, THBS1
20ribonucleic acid4510.0WT1, MUC5AC, MUC1, THBS1, KRT20
21formaldehyde45 2410.9KRT20, KRT7, MUC1, TYMP
22proline459.9WT1, NTS, DNM2, MUC2, MUC5AC, PFN1
23prostaglandin459.9NTS, MUC5AC, THBS1
24doxorubicin45 50 1111.9WT1, STMN1, TYMP, CDK2, THBS1, KRT20
25pd 98,059459.9STMN1, NTS, MUC2, MUC5AC, CDK2, THBS1
26b 723459.8WT1, MUC1, KRT7, KRT20, MSLN, CEACAM7
27actinomycin d459.8TYMP, MUC2, MUC1, CDK2, CEACAM7
28forskolin45 50 1111.8WT1, STMN1, NTS, MUC2, MUC1
29polysaccharide459.8PDIA3, MUC6, MUC5AC, MUC1, THBS1, KRT7
30phosphoinositide459.8NTS, DNM2, CDK2, PFN1, THBS1
31dexamethasone45 50 29 1112.8CDK2, MUC5AC, MUC2, NTS
32oligonucleotide459.7WT1, STMN1, MUC2, MUC6, MUC5AC, THBS1
33cholesterol45 29 11 2412.7DNM2, MUC2, MUC6, MUC5AC, MUC1, CDK2
34threonine459.6WT1, STMN1, MUC2, MUC5AC, MUC1, CDK2
35atp45 2910.6PDIA3, STMN1, NTS, TYMP, MUC5AC, CDK2
365fluorouracil459.6TYMP, MUC2, MUC6, MUC5AC, MUC1, CDK2
37cysteine459.6PDIA3, WT1, TYMP, MUC2, MUC5AC, MUC1
38nitric oxide45 11 2411.5WT1, NTS, TYMP, DNM2, MUC5AC, MUC1
39vegf459.5WT1, TYMP, MUC1, CDK2, THBS1, KRT7
40testosterone45 60 11 2412.4WT1, NTS, MUC5AC, MUC1, CDK2, THBS1
41lipid459.4NTSR1, NTS, DNM2, MUC1, CDK2, PFN1
42thymidine45 2410.4WT1, STMN1, NTSR1, NTS, TYMP, MUC1
43serine459.4WT1, STMN1, NTS, TYMP, MUC2, MUC5AC
44glucose459.3PDIA3, NTS, TYMP, MUC2, MUC5AC, MUC1
45paraffin459.3WT1, NTS, TYMP, MUC2, MUC6, MUC5AC
46retinoic acid45 2410.3WT1, STMN1, MUC2, MUC5AC, MUC1, CDK2
47calcium45 50 11 2412.1PDIA3, STMN1, NTSR1, NTS, MUC2, MUC6
48phosphatidylinositol459.1THBS1, CDK2, MUC5AC, DNM2, NTS, PDIA3
49progesterone45 60 29 11 2412.9CEACAM7, WT1, STMN1, TYMP, MUC2, MUC6
50tyrosine458.6TYMP, NTS, STMN1, WT1, PDIA3, DNM2

GO Terms for genes affiliated with Pancreatic Ductal Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.9MUC1, MUC5AC, MUC6, MUC2

Biological processes related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1O-glycan processingGO:0162669.8MUC1, MUC5AC, MUC6, MUC2
2cellular protein metabolic processGO:0442679.6MUC1, MUC5AC, MUC6, MUC2, PDIA3
3post-translational protein modificationGO:0436879.3PDIA3, MUC2, MUC6, MUC5AC, MUC1

Molecular functions related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.9SEL1L, WT1, NTSR1, NTS, DNM2, MUC2

Products for genes affiliated with Pancreatic Ductal Carcinoma

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  • Proteins
  • Lysates
  • Antibodies

Sources for Pancreatic Ductal Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet