MCID: PNC013
MIFTS: 52

Pancreatic Ductal Carcinoma malady

Cancer diseases, Endocrine diseases categories

Summaries for Pancreatic Ductal Carcinoma

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues forming... more...

MalaCards: Pancreatic Ductal Carcinoma, also known as malignant neoplasm of duct of wirsung, is related to pancreatic cancer and cystadenocarcinoma. An important gene associated with Pancreatic Ductal Carcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are O-linked glycosylation of mucins and Cytoskeletal Signaling. The drugs gemcitabine and gemcitabine hydrochloride and the compounds estrogen and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include pancreas, endothelial and bone, and related mouse phenotypes are homeostasis/metabolism and normal.

Aliases & Classifications for Pancreatic Ductal Carcinoma

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreatic ductal carcinoma 8
malignant neoplasm of duct of wirsung 8
malignant neoplasm of pancreas 60
carcinoma, pancreatic ductal 60
carcinoma pancreatic ductal 44
pancreatic duct cancer 8


External Ids:

Disease Ontology8 DOID:3587
ICD9CM27 157.3
SNOMED-CT56 187793004, 93939009
ICD1025 C25, C25.3

Related Diseases for Pancreatic Ductal Carcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pancreatic Ductal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cancer30.4MUC2, MUC6, MUC5AC, MUC1, CDK2, THBS1
2cystadenocarcinoma30.2MUC2, MUC5AC, MUC1
3adenoma30.2MUC5AC, MUC6, MUC2, NTS, MUC1, CDK2
4pancreatitis11.1
5bone carcinoma10.1
6pancreatic endocrine carcinoma10.1
7microcystic adenoma10.1
8pancreatic cystadenocarcinoma10.1
9pancreas sarcoma10.1
10pancreatoblastoma10.1
11pancreatic cancer, childhood10.1
12pancreatic cancer 110.1
13pancreatic carcinoma, somatic10.1
14pancreatic cancer 310.1
15ampulla of vater neoplasm10.0MUC2
16endometriosis10.0TYMP
17esophagitis10.0NTS
18ulcerative colitis10.0SEL1L
19inflammatory bowel disease10.0MUC2
20cystadenoma10.0KRT7
21asbestosis10.0MSLN
22pituitary adenoma10.0NTS
23gallbladder cancer10.0MUC2
24hepatitis10.0TYMP
25angiosarcoma10.0MUC1
26teratoma10.0KRT7
27sertoli cell tumor10.0MUC1
28ependymoma10.0MUC1
29malignant pleural mesothelioma10.0MSLN
30biliary papillomatosis10.0MUC6, MUC2
31otitis media10.0MUC5AC
32adenomatoid tumor10.0WT1
33renal oncocytoma10.0KRT7
34allergic rhinitis10.0PFN1, MUC2
35meningioma10.0MUC1, NTS
36cervical intraepithelial neoplasia10.0CDK2
37myeloma10.0CDK2
38thymus cancer10.0KRT7, MUC1
39secretory meningioma10.0MUC1, KRT7
40leiomyoma10.0CDK2, TYMP
41renal clear cell carcinoma10.0KRT7, MUC1
42nephrogenic adenoma10.0KRT7
43herpes simplex10.0THBS1
44bladder adenocarcinoma10.0KRT20, KRT7
45rectal neoplasm10.0TYMP, KRT20, CEACAM7
46metanephric adenoma10.0KRT7, WT1
47papillary adenocarcinoma10.0MUC1, MUC2
48signet ring cell adenocarcinoma10.0MUC2, KRT7, KRT20
49papilloma10.0MUC2, MUC5AC
50ovarian brenner tumor10.0KRT7, KRT20

Graphical network of the top 20 diseases related to Pancreatic Ductal Carcinoma:



Diseases related to pancreatic ductal carcinoma

Clinical Features for Pancreatic Ductal Carcinoma

About this section

Drugs & Therapeutics for Pancreatic Ductal Carcinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pancreatic Ductal Carcinoma

Drug clinical trials:

Search ClinicalTrials for Pancreatic Ductal Carcinoma

Search NIH Clinical Center for Pancreatic Ductal Carcinoma

Search CenterWatch for Pancreatic Ductal Carcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pancreatic Ductal Carcinoma

About this section

Anatomical Context for Pancreatic Ductal Carcinoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Pancreatic Ductal Carcinoma:

32
Pancreas, Endothelial, Bone, Bone marrow

Animal Models for Pancreatic Ductal Carcinoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Pancreatic Ductal Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.4STMN1, NTSR1, NTS, MUC2, MUC5AC, PFN1
2MP:00028739.3STMN1, NTSR1, DNM2, MUC1, PFN1, MSLN
3MP:00053848.6SEL1L, PDIA3, WT1, TYMP, DNM2, MUC2
4MP:00053788.5PDIA3, WT1, NTSR1, NTS, DNM2, MUC2

Publications for Pancreatic Ductal Carcinoma

About this section
Sources:
50PubMed
See all sources

Articles related to Pancreatic Ductal Carcinoma:

(show top 50)    (show all 91)
idTitleAuthorsYear
1
Pancreatic intraglandular metastasis predicts poorer outcome in postoperative patients with pancreatic ductal carcinoma. (23648465)
2013
2
Differential ezrin and phosphorylated ezrin expression profiles between pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and invasive ductal carcinoma of the pancreas. (23465281)
2013
3
Metachronous pancreatic head ductal carcinoma three years after resection of gallbladder cancer. (24179579)
2013
4
Pancreatic metastases of renal clear cell carcinoma: a clinicopathological study of 11 cases with special emphasis on the usefulness of PAX2 and mesothelin for the distinction from primary ductal adenocarcinoma of the pancreas. (24344503)
2013
5
Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma. (21841817)
2012
6
Clinicopathologic assessment of pancreatic ductal carcinoma located at the head of the pancreas, in relation to embryonic development. (22228049)
2012
7
Expression of KL-6/MUC1 in pancreatic ductal carcinoma and its potential relationship with I^-catenin in tumor progression. (21466814)
2011
8
Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-1 and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1. (21272935)
2011
9
KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma. (21224073)
2011
10
Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas. (20838624)
2010
11
Pancreatic acinar cell carcinomas with prominent ductal differentiation: Mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma. (20182344)
2010
12
Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma. (19270646)
2009
13
Correlations between p53 gene mutations and histologic characteristics of pancreatic ductal carcinoma. (19248224)
2009
14
Does contrast-enhanced ultrasound reveal tumor angiogenesis in pancreatic ductal carcinoma? A prospective study. (18845377)
2009
15
Amplification of the urokinase-type plasminogen activator receptor (uPAR) gene in ductal pancreatic carcinomas identifies a clinically high-risk group. (19435784)
2009
16
Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma. (19020717)
2008
17
Mixed ductal-endocrine carcinoma of the pancreas with synchronous papillary carcinoma-in-situ of the common bile duct: a case report and literature review--synchronous pancreatic and bile duct tumors. (18453301)
2008
18
The expression of matrix metalloproteinases-2 and -9 and their tissue inhibitor 2 in pancreatic ductal and ampullary carcinoma and their relation to angiogenesis and clinicopathological parameters. (18630474)
2008
19
Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation. (17378244)
2007
20
Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy. (17072983)
2006
21
Pancreatic ductal carcinoma: from the bench to the bedside. (16998251)
2006
22
Reappraisal of the clinical significance of tumor size in patients with pancreatic ductal carcinoma. (17003643)
2006
23
Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A. (16335935)
2005
24
Intercalated duct cell is starting point in development of pancreatic ductal carcinoma? (16018800)
2005
25
Amplification and overexpression of HER-2/neu in invasive ductal carcinomas of the pancreas and pancreatic intraepithelial neoplasms and the relationship to the expression of p21(WAF1/CIP1). (15190415)
2004
26
Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta. (14973050)
2004
27
A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile. (15258755)
2004
28
Evaluation of blood flow in pancreatic ductal carcinoma using contrast-enhanced, wide-band Doppler ultrasonography: correlation with tumor characteristics and vascular endothelial growth factor. (15084983)
2004
29
Cdx2 expression in pancreatic tumors: Relationship with prognosis of invasive ductal carcinomas. (15547744)
2004
30
A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform. (12692724)
2003
31
Expressions of angiogenic factors in pancreatic ductal carcinoma: a correlative study with clinicopathologic parameters and patient survival. (12717266)
2003
32
Expression of transcription factor E2F-1 in pancreatic ductal carcinoma: an immunohistochemical study. (12650514)
2003
33
MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration. (14681945)
2003
34
Proteomic analysis of pancreatic ductal carcinoma cells treated with 5-aza-2'-deoxycytidine. (14679576)
2003
35
Proteomic profiling of pancreatic ductal carcinoma cell lines treated with trichostatin-A. (12783462)
2003
36
The molecular genetics of pancreatic ductal carcinoma. (12370658)
2002
37
Phenotypical characteristics of undifferentiated carcinoma of the pancreas: a comparison with pancreatic ductal adenocarcinoma and relevance of E-cadherin, alpha catenin and beta catenin expression. (11410776)
2001
38
A case of small pancreatic ductal carcinoma accompanied by intraductal mucin-producing pancreatic tumors. (10824701)
2000
39
The molecular genetics of pancreatic ductal carcinoma: a review. (11356337)
2000
40
Centrosome abnormalities in pancreatic ductal carcinoma. (10353727)
1999
41
Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation. (9477096)
1998
42
Ki-ras and p53 gene mutations in pancreatic ductal carcinoma: a relationship with tumor phenotype and survival. (10076772)
1998
43
p53 protein overexpression and K-ras codon 12 mutation in pancreatic ductal carcinoma: correlation with histologic factors. (9293533)
1997
44
Telomerase elevation in pancreatic ductal carcinoma compared to nonmalignant pathological states. (9815776)
1997
45
Chemopreventive activity of Oltipraz against N-nitrosobis(2-oxopropyl)amine (BOP)-induced ductal pancreatic carcinoma development and effects on survival of Syrian golden hamsters. (7554069)
1995
46
Interaction of pancreatic ductal carcinoma with nerves leads to nerve damage. (8020665)
1994
47
Intermediate filaments in rat pancreatic acinar tumors, human ductal carcinomas, and other gastrointestinal malignancies. (7513668)
1994
48
Branch duct origin of solid type pancreatic ductal carcinoma. (8481143)
1993
49
Establishment of hamster pancreatic ductal carcinoma cell line (PC-1) producing blood group-related antigens. (2539915)
1989
50
Dilemma of pancreatic ductal carcinoma. (453140)
1979

Genetic Variations for Pancreatic Ductal Carcinoma

About this section

Expression for genes affiliated with Pancreatic Ductal Carcinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pancreatic Ductal Carcinoma

Search GEO for disease gene expression data for Pancreatic Ductal Carcinoma.

Pathways for genes affiliated with Pancreatic Ductal Carcinoma

About this section
Sources:
53Reactome, 4Cell Signaling Technology, 37NCBI BioSystems Database
See all sources

Pathways related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9MUC1, MUC5AC, MUC6, MUC2
29.8STMN1, DNM2, PFN1, KRT7
3
Hide members
9.8MUC1, MUC5AC, MUC2, PDIA3
49.8WT1, STMN1, CDK2, THBS1

Compounds for genes affiliated with Pancreatic Ductal Carcinoma

About this section
Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB
See all sources

Compounds related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CEACAM7
2sialic acid4410.6KRT7
3hematoxylin4410.5KRT20, KRT7
4sr142948a44 2811.5NTSR1, NTS
5xenin 85910.4NTSR1, NTS
6neurotensin59 2811.4NTSR1, NTS
7jmv 4495910.4NTSR1, NTS
8sr 486925910.4NTSR1, NTS
9sr 1429485910.4NTSR1, NTS
10butyrate4410.4CEACAM7, CDK2
11sr4869244 2811.4NTSR1, NTS
12carbohydrates4410.3MUC5AC, MUC2
13crcs4410.3TYMP, MUC2, MUC1
14mucicarmine4410.2MUC1, KRT7, KRT20, CEACAM7
15levocabastine44 28 1112.1NTS, NTSR1
16hyaluronic acid44 2411.1WT1, MUC1, THBS1, KRT20, MSLN
1712-o-tetradecanoylphorbol 13-acetate4410.0WT1, STMN1, TYMP, MUC2, MUC1, THBS1
18methotrexate44 49 1112.0TYMP, MUC2, MUC5AC, MUC1, KRT7
19dmso4410.0MUC2, MUC5AC, MUC1, CDK2, THBS1
20ribonucleic acid4410.0WT1, MUC5AC, MUC1, THBS1, KRT20
21formaldehyde44 2410.9KRT20, KRT7, MUC1, TYMP
22proline449.9WT1, NTS, DNM2, MUC2, MUC5AC, PFN1
23prostaglandin449.9NTS, MUC5AC, THBS1
24doxorubicin44 49 1111.9WT1, STMN1, TYMP, CDK2, THBS1, KRT20
25pd 98,059449.9STMN1, NTS, MUC2, MUC5AC, CDK2, THBS1
26b 723449.8WT1, MUC1, KRT7, KRT20, MSLN, CEACAM7
27actinomycin d449.8TYMP, MUC2, MUC1, CDK2, CEACAM7
28forskolin44 49 1111.8WT1, STMN1, NTS, MUC2, MUC1
29polysaccharide449.8PDIA3, MUC6, MUC5AC, MUC1, THBS1, KRT7
30phosphoinositide449.8NTS, DNM2, CDK2, PFN1, THBS1
31dexamethasone44 49 28 1112.8CDK2, MUC5AC, MUC2, NTS
32oligonucleotide449.7WT1, STMN1, MUC2, MUC6, MUC5AC, THBS1
33cholesterol44 28 11 2412.7DNM2, MUC2, MUC6, MUC5AC, MUC1, CDK2
34threonine449.6WT1, STMN1, MUC2, MUC5AC, MUC1, CDK2
35atp44 2810.6PDIA3, STMN1, NTS, TYMP, MUC5AC, CDK2
365fluorouracil449.6TYMP, MUC2, MUC6, MUC5AC, MUC1, CDK2
37cysteine449.6PDIA3, WT1, TYMP, MUC2, MUC5AC, MUC1
38nitric oxide44 11 2411.5WT1, NTS, TYMP, DNM2, MUC5AC, MUC1
39vegf449.5WT1, TYMP, MUC1, CDK2, THBS1, KRT7
40testosterone44 59 11 2412.4WT1, NTS, MUC5AC, MUC1, CDK2, THBS1
41lipid449.4NTSR1, NTS, DNM2, MUC1, CDK2, PFN1
42thymidine44 2410.4WT1, STMN1, NTSR1, NTS, TYMP, MUC1
43serine449.4WT1, STMN1, NTS, TYMP, MUC2, MUC5AC
44glucose449.3PDIA3, NTS, TYMP, MUC2, MUC5AC, MUC1
45paraffin449.3WT1, NTS, TYMP, MUC2, MUC6, MUC5AC
46retinoic acid44 2410.3WT1, STMN1, MUC2, MUC5AC, MUC1, CDK2
47calcium44 49 11 2412.1PDIA3, STMN1, NTSR1, NTS, MUC2, MUC6
48phosphatidylinositol449.1THBS1, CDK2, MUC5AC, DNM2, NTS, PDIA3
49progesterone44 59 28 11 2412.9CEACAM7, WT1, STMN1, TYMP, MUC2, MUC6
50tyrosine448.6TYMP, NTS, STMN1, WT1, PDIA3, DNM2

GO Terms for genes affiliated with Pancreatic Ductal Carcinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.9MUC1, MUC5AC, MUC6, MUC2

Biological processes related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1O-glycan processingGO:0162669.8MUC1, MUC5AC, MUC6, MUC2
2cellular protein metabolic processGO:0442679.6MUC1, MUC5AC, MUC6, MUC2, PDIA3
3post-translational protein modificationGO:0436879.3PDIA3, MUC2, MUC6, MUC5AC, MUC1

Molecular functions related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.9SEL1L, WT1, NTSR1, NTS, DNM2, MUC2

Products for genes affiliated with Pancreatic Ductal Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pancreatic Ductal Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet