MCID: PNC013
MIFTS: 51

Pancreatic Ductal Carcinoma malady

Cancer diseases, Endocrine diseases categories
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Summaries for Pancreatic Ductal Carcinoma

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Wikipedia:65 Pancreatic cancer occurs when cancer cells develop in the pancreas, a glandular organ located behind the... more...

MalaCards based summary: Pancreatic Ductal Carcinoma, also known as malignant neoplasm of duct of wirsung, is related to cystadenocarcinoma and pancreatic cancer. An important gene associated with Pancreatic Ductal Carcinoma is SMAD4 (SMAD family member 4), and among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and O-linked glycosylation of mucins. The drugs gemcitabine and gemcitabine hydrochloride and the compounds hematoxylin and galactose have been mentioned in the context of this disorder. Affiliated tissues include the pancreatic duct, pancreas and skin, and related mouse phenotypes are tumorigenesis and cellular.

Disease Ontology:8 A pancreatic carcinoma located in the pancreatic duct.

Aliases & Classifications for Pancreatic Ductal Carcinoma

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Sources:
8Disease Ontology, 62UMLS, 44Novoseek, 27ICD9CM, 57SNOMED-CT, 25ICD10
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Pancreatic Ductal Carcinoma, Aliases & Descriptions:

Name: Pancreatic Ductal Carcinoma 8
Malignant Neoplasm of Duct of Wirsung 8 62
Malignant Neoplasm of Pancreas 62
 
Carcinoma, Pancreatic Ductal 62
Carcinoma Pancreatic Ductal 44
Pancreatic Duct Cancer 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:3587
ICD9CM27 157.3
SNOMED-CT57 187793004, 93939009
ICD1025 C25.3

Related Diseases for Pancreatic Ductal Carcinoma

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Diseases related to Pancreatic Ductal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1cystadenocarcinoma30.4MUC2, MUC1
2pancreatic cancer30.3SMAD4, MUC2
3adenoma29.8MUC6, MUC2, MUC1, SMAD4
4pancreatitis11.1
5endotheliitis10.3
6biliary papillomatosis10.3MUC2, MUC6
7bile duct carcinoma10.2SMAD4, MUC2
8pseudomyxoma peritonei10.2MUC2, MUC6
9bronchiolo-alveolar adenocarcinoma10.2MUC2, MUC6
10barrett's esophagus10.2MUC2, MUC6
11microcystic adenoma10.2
12adenosquamous pancreas carcinoma10.2
13ovarian serous carcinoma10.2
14pancreatic cystadenocarcinoma10.2
15hypoxia10.2
16microinvasive gastric cancer10.2TYMP, MUC2
17allergic rhinitis10.1PFN1, MUC2
18colitis10.1MUC2, SMAD4
19papillary adenocarcinoma10.1MUC2, MUC1
20esophageal cancer10.1SMAD4, TYMP
21leiomyoma10.1SMAD4, TYMP
22tubular adenocarcinoma10.1MUC1, MUC2
23mucoepidermoid carcinoma10.1MUC2, MUC1
24colon adenocarcinoma10.1SMAD4, MUC2
25mucinous cystadenocarcinoma10.0SMAD4, MUC1
26bladder carcinoma10.0TYMP, MUC2
27pancreatitis, chronic10.0MUC2, SMAD4, MUC6
28familial adenomatous polyposis10.0SMAD4, MUC2, MUC6
29gallbladder cancer10.0TYMP, SMAD4, MUC2
30endometrial carcinoma10.0TYMP, MUC1
31squamous cell carcinoma of the head and neck10.0SMAD4, TYMP
32gastric adenocarcinoma10.0SMAD4, TYMP, MUC2
33non-small cell lung carcinoma9.9SMAD4, MUC2, TYMP
34colonic benign neoplasm9.9TYMP, MUC2, SMAD4
35papillary carcinoma9.9MUC2, SMAD4, MUC1
36cholangiocarcinoma9.9MUC1, MUC2, SMAD4
37liver cancer9.9TYMP, SMAD4, MUC2
38adenosquamous carcinoma9.8MUC1, MUC2, TYMP
39lung cancer9.8MUC2, SMAD4, TYMP
40cervical cancer9.8SMAD4, TYMP
41colorectal cancer9.8MUC2, TYMP, SMAD4, MUC6
42lung adenocarcinoma9.8TYMP, SMAD4, MUC1
43stomach cancer9.8TYMP, SMAD4, MUC2, MUC6
44ovarian cancer9.7TYMP, SMAD4, MUC1
45tongue squamous cell carcinoma9.4TYMP, MUC1, MUC6, MUC2, SMAD4
46adenocarcinoma9.4MUC1, TYMP, SMAD4, MUC2, MUC6
47breast cancer9.2MUC2, MUC1, PFN1, SMAD4, TYMP, MUC6

Graphical network of the top 20 diseases related to Pancreatic Ductal Carcinoma:



Diseases related to pancreatic ductal carcinoma

Symptoms for Pancreatic Ductal Carcinoma

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Drugs & Therapeutics for Pancreatic Ductal Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Pancreatic Ductal Carcinoma

Search NIH Clinical Center for Pancreatic Ductal Carcinoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Pancreatic Ductal Carcinoma

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Anatomical Context for Pancreatic Ductal Carcinoma

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MalaCards organs/tissues related to Pancreatic Ductal Carcinoma:

32
Pancreas, Skin, Endothelial, Bone marrow, Bone, Liver

FMA organs/tissues related to Pancreatic Ductal Carcinoma:

14
The pancreatic duct

Animal Models for Pancreatic Ductal Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Pancreatic Ductal Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0SMAD4, MUC2, MUC1
2MP:00053848.2MUC2, PFN1, SMAD4, TYMP
3MP:00053877.9TYMP, SMAD4, PFN1, MUC2
4MP:00053767.6MUC1, MUC2, PFN1, SMAD4, TYMP

Publications for Pancreatic Ductal Carcinoma

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Articles related to Pancreatic Ductal Carcinoma:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Clinicopathological Significance of ASC-Amino Acid Transporter 2 (ASCT2) Expression in Pancreatic Ductal Carcinoma. (24845232)
2014
2
Alteration of strain ratio evaluated by transabdominal ultrasound elastography may predict the efficacy of preoperative chemoradiation performed for pancreatic ductal carcinoma: preliminary results. (24901166)
2014
3
Successful management of metachronous liver metastasis after pancreaticoduodectomy for pancreatic ductal carcinoma using hepatectomy and chemotherapy: a case report. (24778053)
2014
4
Pancreatic intraglandular metastasis predicts poorer outcome in postoperative patients with pancreatic ductal carcinoma. (23648465)
2013
5
Preoperative platelet-lymphocyte ratio in resected pancreatic ductal carcinoma: is it meaningful? (20579970)
2012
6
Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue. (22892044)
2012
7
Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model. (22190076)
2012
8
Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma. (21841817)
2012
9
Expression of KL-6/MUC1 in pancreatic ductal carcinoma and its potential relationship with I^-catenin in tumor progression. (21466814)
2011
10
Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-1 and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1. (21272935)
2011
11
Cytologic features of pancreatic intraepithelial neoplasia and pancreatitis: potential pitfalls in the diagnosis of pancreatic ductal carcinoma. (20730891)
2011
12
KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma. (21224073)
2011
13
Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology. (19856421)
2010
14
Expression of EGF and EGFR strongly correlates with metastasis of pancreatic ductal carcinoma. (18505086)
2008
15
Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma. (19020717)
2008
16
Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy. (17072983)
2006
17
Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma. (15985168)
2005
18
Factors predicting recurrence after resection of pancreatic ductal carcinoma. (15968250)
2005
19
Evaluation of vascular signal in pancreatic ductal carcinoma using contrast enhanced ultrasonography: effect of systemic chemotherapy. (15951559)
2005
20
Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A. (16335935)
2005
21
Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta. (14973050)
2004
22
A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile. (15258755)
2004
23
Evaluation of blood flow in pancreatic ductal carcinoma using contrast-enhanced, wide-band Doppler ultrasonography: correlation with tumor characteristics and vascular endothelial growth factor. (15084983)
2004
24
Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays. (15548371)
2004
25
A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform. (12692724)
2003
26
Expressions of angiogenic factors in pancreatic ductal carcinoma: a correlative study with clinicopathologic parameters and patient survival. (12717266)
2003
27
Expression of transcription factor E2F-1 in pancreatic ductal carcinoma: an immunohistochemical study. (12650514)
2003
28
Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinoma. (12824920)
2003
29
MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration. (14681945)
2003
30
Vascular endothelial growth factor mediated angiogenic potential of pancreatic ductal carcinomas enhanced by hypoxia: an in vitro and in vivo study. (12448000)
2002
31
The molecular genetics of pancreatic ductal carcinoma. (12370658)
2002
32
Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. (12429967)
2002
33
Endocrine and intermediate cells in pancreatic ductal carcinoma and in chronic pancreatitis. (12533945)
2002
34
Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. (11238189)
2001
35
Heterogeneic distribution of thymidine phosphorylase between primary tumors and metastatic lesions of human pancreatic ductal carcinoma: implications for the efficacy of chemotherapy with 5-FU or its derivatives. (11391857)
2001
36
A case of small pancreatic ductal carcinoma accompanied by intraductal mucin-producing pancreatic tumors. (10824701)
2000
37
Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation. (9477096)
1998
38
Ki-ras and p53 gene mutations in pancreatic ductal carcinoma: a relationship with tumor phenotype and survival. (10076772)
1998
39
Isolation of a pancreas-specific gene located on human chromosome 14q31: expression analysis in human pancreatic ductal carcinomas. (9417916)
1997
40
p53 protein overexpression and K-ras codon 12 mutation in pancreatic ductal carcinoma: correlation with histologic factors. (9293533)
1997
41
Telomerase elevation in pancreatic ductal carcinoma compared to nonmalignant pathological states. (9815776)
1997
42
Differentiation of pancreatic ductal carcinoma cells associated with selective expression of protein kinase C isoforms. (8915489)
1996
43
Hematogenous metastases of pancreatic ductal carcinoma. (8532650)
1995
44
Comparative molecular field analysis of the antitumor activity of 9H-thioxanthen-9-one derivatives against pancreatic ductal carcinoma 03. (8145227)
1994
45
Comparison between a newly established pancreatic cystadenocarcinoma cell-line, ocup-1 and cells derived from pancreatic ductal carcinoma. (21567058)
1994
46
Interaction of pancreatic ductal carcinoma with nerves leads to nerve damage. (8020665)
1994
47
Sustained recovery from a solid type pancreatic ductal carcinoma originating in the pancreas tail: a case report. (8385066)
1993
48
Branch duct origin of solid type pancreatic ductal carcinoma. (8481143)
1993
49
Establishment of hamster pancreatic ductal carcinoma cell line (PC-1) producing blood group-related antigens. (2539915)
1989
50
Dilemma of pancreatic ductal carcinoma. (453140)
1979

Variations for Pancreatic Ductal Carcinoma

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Clinvar genetic disease variations for Pancreatic Ductal Carcinoma:

6
id Gene Name Type Significance SNP ID Assembly Location
1SMAD4NM_005359.5(SMAD4): c.1236C> G (p.Tyr412Ter)single nucleotide variantPathogenicrs121912577GRCh37Chr 18, 48593485: 48593485

Expression for genes affiliated with Pancreatic Ductal Carcinoma

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Expression patterns in normal tissues for genes affiliated with Pancreatic Ductal Carcinoma

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Pathways for genes affiliated with Pancreatic Ductal Carcinoma

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Compounds for genes affiliated with Pancreatic Ductal Carcinoma

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Compounds related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1hematoxylin449.8MUC2, MUC1
2galactose449.8MUC1, MUC2
3sulfate44 2410.7MUC1, MUC2
4dihydrotestosterone44 28 24 1112.7MUC1, SMAD4
5sialic acid449.6MUC2, MUC1
6agarose449.6MUC2, MUC1
7carbohydrates449.5MUC2, MUC1
8lead449.5SMAD4, TYMP
9gemcitabine44 50 1111.4TYMP, MUC1
10purine44 2410.4MUC1, TYMP
11oligonucleotide449.4SMAD4, MUC2, MUC6
12threonine449.3MUC1, MUC2, SMAD4
13cholesterol44 28 24 1112.3MUC6, MUC1, MUC2
14thymidine44 2410.1TYMP, SMAD4, MUC1
15methotrexate50 44 1111.0MUC1, MUC2, TYMP
16formaldehyde44 2410.0MUC1, TYMP
1712-o-tetradecanoylphorbol 13-acetate449.0TYMP, MUC2, MUC1
18actinomycin d449.0MUC1, MUC2, TYMP
19vegf449.0MUC1, SMAD4, TYMP
20nitric oxide44 24 1110.9TYMP, SMAD4, MUC1
21folate448.8MUC1, TYMP
22cysteine448.7MUC1, MUC2, TYMP
23crcs448.7MUC1, MUC2, SMAD4, TYMP
24glucose448.6TYMP, SMAD4, MUC2, MUC1
25serine448.6MUC1, MUC2, SMAD4, TYMP
265fluorouracil448.5TYMP, MUC2, MUC1, MUC6
27progesterone44 28 61 24 1112.5TYMP, MUC2, MUC1, MUC6
28paraffin448.1TYMP, SMAD4, MUC2, MUC1, MUC6
29estrogen448.1MUC6, MUC1, MUC2, SMAD4, TYMP

GO Terms for genes affiliated with Pancreatic Ductal Carcinoma

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Cellular components related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.0MUC6, MUC1, MUC2

Biological processes related to Pancreatic Ductal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1maintenance of gastrointestinal epitheliumGO:0302779.4MUC6, MUC2
2O-glycan processingGO:0162669.0MUC6, MUC1, MUC2
3cellular protein metabolic processGO:0442679.0MUC6, MUC1, MUC2
4post-translational protein modificationGO:0436878.7MUC2, MUC1, MUC6

Products for genes affiliated with Pancreatic Ductal Carcinoma

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Sources for Pancreatic Ductal Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet