MCID: PNC013
MIFTS: 47

Pancreatic Ductal Carcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pancreatic Ductal Carcinoma

MalaCards integrated aliases for Pancreatic Ductal Carcinoma:

Name: Pancreatic Ductal Carcinoma 12 14
Carcinoma, Pancreatic Ductal 41 69
Malignant Neoplasm of Duct of Wirsung 12
Carcinoma Pancreatic Ductal 51
Pancreatic Duct Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3587
ICD10 32 C25.3
ICD9CM 34 157.3
MeSH 41 D021441
SNOMED-CT 64 187793004 93939009

Summaries for Pancreatic Ductal Carcinoma

Disease Ontology : 12 A pancreatic carcinoma located in the pancreatic duct.

MalaCards based summary : Pancreatic Ductal Carcinoma, also known as carcinoma, pancreatic ductal, is related to adenosquamous pancreas carcinoma and microcystic adenoma. An important gene associated with Pancreatic Ductal Carcinoma is MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. The drugs Gemcitabine and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include the pancreatic duct, pancreas and endothelial, and related phenotypes are cellular and neoplasm

Related Diseases for Pancreatic Ductal Carcinoma

Diseases related to Pancreatic Ductal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
# Related Disease Score Top Affiliating Genes
1 adenosquamous pancreas carcinoma 31.3 KRT7 SMAD4
2 microcystic adenoma 30.5 MUC1 MUC6
3 cystadenocarcinoma 29.2 KRT7 MUC1 MUC2 TP53 VEGFA
4 adenoma 28.9 KRT7 MUC2 SMAD4 TP53
5 adenocarcinoma 28.3 CDKN2A MUC1 SMAD4 TP53 VEGFA
6 pancreatic cancer 27.5 CDKN2A MUC1 MUC2 MUC6 SMAD4 TP53
7 pancreatitis 10.7
8 middle ear adenoma 10.5 KRT7 MUC1
9 endosalpingiosis 10.5 KRT7 MUC1
10 parachordoma 10.5 KRT7 MUC1
11 malignant mixed mullerian tumor 10.5 KRT7 MUC1
12 nodular hidradenoma 10.5 KRT7 MUC1
13 eccrine porocarcinoma 10.5 KRT7 MUC1
14 apocrine adenocarcinoma 10.5 KRT7 MUC1
15 monophasic synovial sarcoma 10.5 KRT7 MUC1
16 nephrogenic adenoma 10.5 KRT7 MUC1
17 mucinous ovarian cystadenoma 10.5 KRT7 MUC1
18 pancreatic serous cystadenoma 10.5 KRT7 VEGFA
19 hidradenoma 10.5 KRT7 MUC1
20 cystic basal cell carcinoma 10.4 KRT20 KRT7
21 lung acinar adenocarcinoma 10.4 KRT20 KRT7
22 vaginal benign neoplasm 10.4 KRT20 KRT7
23 seminal vesicle adenocarcinoma 10.4 KRT20 KRT7
24 sertoli-leydig cell tumor 10.4 KRT7 MUC1
25 transverse colon cancer 10.4 KRT20 KRT7
26 ovarian large-cell neuroendocrine carcinoma 10.4 KRT20 KRT7
27 vaginal adenoma 10.4 KRT20 KRT7
28 vaginal tubulovillous adenoma 10.4 KRT20 KRT7
29 eyelid neoplasm 10.4 KRT20 KRT7
30 malignant syringoma 10.4 KRT20 KRT7
31 krukenberg carcinoma 10.4 KRT20 KRT7
32 large intestine adenocarcinoma 10.4 KRT20 KRT7
33 linitis plastica 10.4 KRT20 KRT7
34 small cell carcinoma of the bladder 10.4 KRT20 KRT7
35 adenoid squamous cell carcinoma 10.4 KRT20 KRT7
36 bladder adenocarcinoma 10.4 KRT20 KRT7
37 intratubular embryonal carcinoma 10.4 KRT20 KRT7
38 thymus adenocarcinoma 10.4 KRT20 KRT7
39 gastric diffuse adenocarcinoma 10.4 KRT20 KRT7
40 meibomian cyst 10.4 KRT20 KRT7
41 bladder lymphoma 10.4 KRT20 KRT7
42 sclerosing hemangioma 10.4 KRT7 MUC1
43 jejunal adenocarcinoma 10.4 KRT20 KRT7
44 lipoadenoma 10.4 KRT7 MUC1
45 chronic cystitis 10.4 KRT20 KRT7
46 villous adenoma 10.4 KRT20 MUC1
47 rectum adenocarcinoma 10.4 KRT20 KRT7
48 medulloepithelioma 10.4 KRT20 KRT7
49 malignant spiradenoma 10.4 KRT7 TP53
50 chordoid glioma 10.4 MUC1 TP53

Graphical network of the top 20 diseases related to Pancreatic Ductal Carcinoma:



Diseases related to Pancreatic Ductal Carcinoma

Symptoms & Phenotypes for Pancreatic Ductal Carcinoma

MGI Mouse Phenotypes related to Pancreatic Ductal Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.56 CDKN2A KRT7 MUC2 SMAD4 TGM2 TP53
2 neoplasm MP:0002006 9.1 CDKN2A MUC2 SMAD4 TGM2 TP53 VEGFA

Drugs & Therapeutics for Pancreatic Ductal Carcinoma

Drugs for Pancreatic Ductal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 3,Phase 2,Phase 1 95058-81-4 60750
2
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741 24759
3
Paclitaxel Approved, Vet_approved Phase 3,Phase 1,Phase 2 33069-62-4 36314
4 acivicin Phase 3
5 Adjuvants, Immunologic Phase 3
6 Albumin-Bound Paclitaxel Phase 3,Phase 1,Phase 2
7 Anti-Infective Agents Phase 3,Phase 1,Phase 2
8 Antimetabolites Phase 3,Phase 1,Phase 2
9 Antimetabolites, Antineoplastic Phase 3,Phase 1,Phase 2
10 Antimitotic Agents Phase 3,Phase 1,Phase 2
11 Antineoplastic Agents, Phytogenic Phase 3,Phase 1,Phase 2
12 Antiviral Agents Phase 3,Phase 1,Phase 2
13 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
14 Protective Agents Phase 3
15 Viscosupplements Phase 3
16
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
17
Pancrelipase Approved, Investigational Phase 1, Phase 2 53608-75-6
18
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
19
Doxil Approved June 1999 Phase 2 31703
20
Tremelimumab Investigational Phase 2 745013-59-6
21 Anti-Bacterial Agents Phase 2
22 Antibiotics, Antitubercular Phase 2
23 Topoisomerase Inhibitors Phase 2
24 Antibodies Phase 2,Phase 1
25 Antibodies, Monoclonal Phase 2,Phase 1
26 Immunoglobulins Phase 2,Phase 1
27 pancreatin Phase 1, Phase 2
28 Cola Nutraceutical Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of PEGylated Recombinant Human Hyaluronidase in Combination With Nab-Paclitaxel Plus Gemcitabine Compared With Placebo Plus Nab-Paclitaxel and Gemcitabine in Participants With Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal Adenoca Recruiting NCT02715804 Phase 3 Placebo;Nab-paclitaxel;Gemcitabine
2 Pilot Phase 2 Study to Investigate the Preliminary Efficacy and Safety of INNO-206 in Advanced Pancreatic Cancer Completed NCT01580397 Phase 2 INNO-206
3 Phase II Study of MEDI4736 Monotherapy or in Combinations With Tremelimumab in Metastatic Pancreatic Ductal Carcinoma Completed NCT02558894 Phase 2 MEDI4736 monotherapy;tremelimumab+MEDI4736
4 QUILT-3.019: Phase 2 Study of NPC-1C Chimeric Monoclonal Antibody to Treat Pancreatic and Colorectal Cancer Completed NCT01040000 Phase 1, Phase 2 NPC-1C/NEO-102
5 Phase Ib/II Study of MEDI4736 Evaluated in Different Combinations in Metastatic Pancreatic Ductal Carcinoma Recruiting NCT02583477 Phase 1, Phase 2 MEDI4736 in combination with nab-paclitaxel and gemcitabine;MEDI4736 in combination with AZD5069
6 PEGPH20 Plus Nab-Paclitaxel Plus Gemcitabine Compared With Nab-Paclitaxel Plus Gemcitabine in Subjects With Stage IV Untreated Pancreatic Cancer Active, not recruiting NCT01839487 Phase 2 PEGPH20+nab-paclitaxel+gemcitabine;nab-paclitaxel + gemcitabine
7 Phase II Study of Preoperative FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel in Patients With Resectable Pancreatic Cancer Terminated NCT02243007 Phase 2 FOLFIRINOX;Gemcitabine/nab-Paclitaxel;Capecitabine
8 A Dose-Finding Study of OTX105/MK-8628, a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Adults With Selected Advanced Solid Tumors (MK-8628-003) Completed NCT02259114 Phase 1 OTX015/MK-8628

Search NIH Clinical Center for Pancreatic Ductal Carcinoma

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: carcinoma, pancreatic ductal

Genetic Tests for Pancreatic Ductal Carcinoma

Anatomical Context for Pancreatic Ductal Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Pancreatic Ductal Carcinoma:

18
The Pancreatic Duct

MalaCards organs/tissues related to Pancreatic Ductal Carcinoma:

38
Pancreas, Endothelial, T Cells, Liver, Bone, Bone Marrow

Publications for Pancreatic Ductal Carcinoma

Articles related to Pancreatic Ductal Carcinoma:

(show top 50) (show all 84)
# Title Authors Year
1
Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal carcinoma treated with individualized, neoepitope-derived multipeptide vaccines: a case report. ( 29409514 )
2018
2
Adjuvant treatment for pancreatic ductal carcinoma. ( 28639051 )
2017
3
Plasma membrane expression of ZNF185 is a prognostic factor in pancreatic ductal carcinoma. ( 28927124 )
2017
4
The Clinical Significance of miR-34a in Pancreatic Ductal Carcinoma and Associated Molecular and Cellular Mechanisms. ( 27458977 )
2017
5
Immunohistochemical Antibody Panel for the Differential Diagnosis of Pancreatic Ductal Carcinoma From Gastrointestinal Contamination and Benign Pancreatic Duct Epithelium in Endoscopic Ultrasound-Guided Fine-Needle Aspiration. ( 28099249 )
2017
6
Functions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma. ( 29254283 )
2017
7
Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation. ( 29273724 )
2017
8
A case report on metastatic pancreatic tumor from pulmonary adenocarcinoma that difficult to differentiate from primary pancreatic ductal carcinoma. ( 27498937 )
2016
9
Insulin resistance is associated with the aggressiveness of pancreatic ductal carcinoma. ( 27552832 )
2016
10
Second primary pancreatic ductal carcinoma in the remnant pancreas after pancreatectomy for pancreatic ductal carcinoma: High cumulative incidence rates at 5 years after pancreatectomy. ( 27237099 )
2016
11
Efficacy of contrast-enhanced harmonic endoscopic ultrasonography in the diagnosis of pancreatic ductal carcinoma. ( 27184637 )
2016
12
Alternative splicing of NUMB, APP and VEGFA as the features of pancreatic ductal carcinoma. ( 26261495 )
2015
13
Alteration of strain ratio evaluated by transabdominal ultrasound elastography may predict the efficacy of preoperative chemoradiation performed for pancreatic ductal carcinoma: preliminary results. ( 24901166 )
2014
14
Successful management of metachronous liver metastasis after pancreaticoduodectomy for pancreatic ductal carcinoma using hepatectomy and chemotherapy: a case report. ( 24778053 )
2014
15
Clinicopathological Significance of ASC-Amino Acid Transporter 2 (ASCT2) Expression in Pancreatic Ductal Carcinoma. ( 24845232 )
2014
16
Pancreatic intraglandular metastasis predicts poorer outcome in postoperative patients with pancreatic ductal carcinoma. ( 23648465 )
2013
17
Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma. ( 21841817 )
2012
18
Clinicopathologic assessment of pancreatic ductal carcinoma located at the head of the pancreas, in relation to embryonic development. ( 22228049 )
2012
19
Assessment of the interface between retroperitoneal fat infiltration of pancreatic ductal carcinoma and the major artery by multidetector-row computed tomography: surgical outcomes and correlation with histopathological extension. ( 22562451 )
2012
20
Preoperative platelet-lymphocyte ratio in resected pancreatic ductal carcinoma: is it meaningful? ( 20579970 )
2012
21
Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue. ( 22892044 )
2012
22
Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model. ( 22190076 )
2012
23
Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-1 and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1. ( 21272935 )
2011
24
Cytologic features of pancreatic intraepithelial neoplasia and pancreatitis: potential pitfalls in the diagnosis of pancreatic ductal carcinoma. ( 20730891 )
2011
25
Expression of KL-6/MUC1 in pancreatic ductal carcinoma and its potential relationship with I^-catenin in tumor progression. ( 21466814 )
2011
26
KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma. ( 21224073 )
2011
27
Asymptomatic curable pancreatic ductal carcinoma detected during the follow-up of pancreatic cysts distinct from carcinoma. ( 26190721 )
2011
28
Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology. ( 19856421 )
2010
29
Correlations between p53 gene mutations and histologic characteristics of pancreatic ductal carcinoma. ( 19248224 )
2009
30
Does contrast-enhanced ultrasound reveal tumor angiogenesis in pancreatic ductal carcinoma? A prospective study. ( 18845377 )
2009
31
Expression of EGF and EGFR strongly correlates with metastasis of pancreatic ductal carcinoma. ( 18505086 )
2008
32
Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma. ( 19020717 )
2008
33
Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation. ( 17378244 )
2007
34
Reappraisal of the clinical significance of tumor size in patients with pancreatic ductal carcinoma. ( 17003643 )
2006
35
Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy. ( 17072983 )
2006
36
Pancreatic ductal carcinoma: from the bench to the bedside. ( 16998251 )
2006
37
Intercalated duct cell is starting point in development of pancreatic ductal carcinoma? ( 16018800 )
2005
38
Experimental trial for diagnosis of pancreatic ductal carcinoma based on gene expression profiles of pancreatic ductal cells. ( 16053509 )
2005
39
Factors predicting recurrence after resection of pancreatic ductal carcinoma. ( 15968250 )
2005
40
Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma. ( 15985168 )
2005
41
Retroviral expression screening of oncogenes in pancreatic ductal carcinoma. ( 16125925 )
2005
42
Evaluation of vascular signal in pancreatic ductal carcinoma using contrast enhanced ultrasonography: effect of systemic chemotherapy. ( 15951559 )
2005
43
Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A. ( 16335935 )
2005
44
Detection of tumor cell dissemination in pancreatic ductal carcinoma patients by CK 20 RT-PCR indicates poor survival. ( 16136352 )
2005
45
Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines. ( 15084985 )
2004
46
Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives. ( 14745573 )
2004
47
Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta. ( 14973050 )
2004
48
Terminally modified oligodeoxynucleotides directed against p53 in an orthotopic xenograft model: a novel adjuvant treatment strategy for pancreatic ductal carcinoma. ( 14707723 )
2004
49
Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays. ( 15548371 )
2004
50
A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile. ( 15258755 )
2004

Variations for Pancreatic Ductal Carcinoma

Expression for Pancreatic Ductal Carcinoma

Search GEO for disease gene expression data for Pancreatic Ductal Carcinoma.

Pathways for Pancreatic Ductal Carcinoma

Pathways related to Pancreatic Ductal Carcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1 12.59 CDKN2A SMAD4 TP53 VEGFA
2
Show member pathways
12.48 CDKN2A MUC2 SMAD4 TP53
3
Show member pathways
12.01 MUC1 MUC2 MUC6
4 11.95 SMAD4 TP53 VEGFA
5 11.89 SMAD4 TP53 VEGFA
6
Show member pathways
11.82 MUC1 MUC2 MUC6
7 11.69 CDKN2A SMAD4 TP53
8 11.67 MUC1 TP53 VEGFA
9
Show member pathways
11.62 MUC1 MUC2 MUC6
10 11.57 CDKN2A SMAD4 TP53
11 11.54 CDKN2A SMAD4 TP53 VEGFA
12
Show member pathways
11.44 CDKN2A SMAD4 TP53 VEGFA
13 11.23 CDKN2A TP53 VEGFA
14 11.14 SMAD4 TP53 VEGFA
15 10.89 CDKN2A TP53
16
Show member pathways
10.88 CDKN2A TP53
17 10.82 MUC2 SMAD4
18 10.79 CDKN2A TP53 TYMP VEGFA

GO Terms for Pancreatic Ductal Carcinoma

Cellular components related to Pancreatic Ductal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC1 MUC2 MUC6

Biological processes related to Pancreatic Ductal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.54 MUC1 MUC2 MUC6
2 negative regulation of cell growth GO:0030308 9.43 CDKN2A SMAD4 TP53
3 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.4 MUC1 TP53
4 positive regulation of leukocyte migration GO:0002687 9.32 TP53 VEGFA
5 replicative senescence GO:0090399 9.16 CDKN2A TP53
6 maintenance of gastrointestinal epithelium GO:0030277 8.96 MUC2 MUC6
7 O-glycan processing GO:0016266 8.8 MUC1 MUC2 MUC6

Sources for Pancreatic Ductal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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