MCID: PNC008
MIFTS: 51

Pancreatic Endocrine Carcinoma malady

Cancer diseases, Neuronal diseases, Endocrine diseases categories

Summaries for Pancreatic Endocrine Carcinoma

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34MalaCards
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MalaCards: Pancreatic Endocrine Carcinoma, also known as malignant neoplasm of islets of langerhans, any part of pancreas, is related to neuroendocrine carcinoma and acromegaly. An important gene associated with Pancreatic Endocrine Carcinoma is SSTR5 (somatostatin receptor 5), and among its related pathways are Signal transduction by L1 and Peptide ligand-binding receptors. The drug dacarbazine and the compounds bim 23059 and [125i]tyr3 sms 201-995 have been mentioned in the context of this disorder. Affiliated tissues include pancreas and liver, and related mouse phenotypes are digestive/alimentary and cardiovascular system.

Aliases & Classifications for Pancreatic Endocrine Carcinoma

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9Disease Ontology, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases, Endocrine diseases


Aliases & Descriptions:

pancreatic endocrine carcinoma 9 63
malignant neoplasm of islets of langerhans, any part of pancreas 9
malignant neoplasm of islets of langerhans 9
malignant neoplasm of endocrine pancreas 63
malignant tumor of islets of langerhans 9
malignant tumor of endocrine pancreas 9
malignant pancreatic endocrine tumor 9
pancreatic neuroendocrine carcinoma 9
carcinoma of endocrine pancreas 9
endocrine pancreas cancer 9
islet cell carcinoma 9


External Ids:

Disease Ontology9 DOID:1798, DOID:10165
NCIt41 C3770
MeSH36 D018273
ICD9CM28 157.4
ICD1026 C25.4

Related Diseases for Pancreatic Endocrine Carcinoma

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18GeneCards, 19GeneDecks
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Diseases related to Pancreatic Endocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine carcinoma31.0NCAM1, CALCA, SYP, SST
2acromegaly30.4SSTR2, SST, SSTR5
3primary hyperparathyroidism30.3PTHLH, CALCA
4hyperparathyroidism30.3CALCA, PTHLH
5islet cell tumor30.3SST, PTHLH
6neuroendocrine tumor30.3SST, SSTR2, CALCA
7cushing's syndrome30.2SST, SYP, CALCA
8prolactinoma30.2PTHLH, SSTR5, SST, SSTR2, NCAM1
9somatostatinoma30.2SST, SSTR2, CALCA
10hypercalcemia30.2PTHLH, CALCA
11pancreatic islet cell tumors30.2PTHLH, SST, SYP, CALCA
12adenocarcinoma29.9SMAD4, PTHLH, SST, SSTR2, SYP, NCAM1
13pancreatitis10.7
14pancreatic endocrine tumors10.6
15zollinger-ellison syndrome10.3
16diabetes insipidus10.2
17tuberous sclerosis10.2
18thyroiditis10.2
19multiple endocrine neoplasia10.2
20endotheliitis10.2
21diabetic ketoacidosis10.1
22cholera10.1
23hyperthyroxinemia10.1
24acinar cell carcinoma10.1
25pancreatic cholera10.1
26dermatitis10.1
27pneumonia10.1
28chylous ascites10.1
29humoral hypercalcemia of malignancy10.1
30subependymal giant cell astrocytoma10.1SYP
31cholangitis10.1
32hepatitis10.1
33cowden disease10.1SMAD4
34giant cell glioblastoma10.1EGFR
35osteomalacia10.1CALCA, PTHLH
36endocrine gland cancer10.1SST, SYP
37pseudohypoparathyroidism10.1CALCA, PTHLH
38parathyroid adenoma10.1PTHLH, CALCA
39hypoparathyroidism10.1PTHLH, CALCA
40wdha syndrome10.1SST, CALCA
41apudoma10.1SST, CALCA
42hypophosphatemia10.1PTHLH, CALCA
43secondary hyperparathyroidism of renal origin10.1PTHLH, CALCA
44hyperprolactinemia10.1PTHLH, SST
45clear cell adenocarcinoma10.1PTHLH, SMAD4
46osteoporosis, postmenopausal10.1PTHLH, CALCA
47vipoma10.1SMAD4, SST
48thyroid cancer, anaplastic10.1PTHLH, CALCA
49neuroepithelioma10.1SYP, NCAM1
50adenosquamous carcinoma10.1PTHLH, EGFR

Graphical network of the top 20 diseases related to Pancreatic Endocrine Carcinoma:



Diseases related to pancreatic endocrine carcinoma

Symptoms for Pancreatic Endocrine Carcinoma

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Drugs & Therapeutics for Pancreatic Endocrine Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Pancreatic Endocrine Carcinoma

Drug clinical trials:

Search ClinicalTrials for Pancreatic Endocrine Carcinoma

Search NIH Clinical Center for Pancreatic Endocrine Carcinoma

Search CenterWatch for Pancreatic Endocrine Carcinoma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Pancreatic Endocrine Carcinoma

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Anatomical Context for Pancreatic Endocrine Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Pancreatic Endocrine Carcinoma:

34
Pancreas, Liver

Animal Models for Pancreatic Endocrine Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pancreatic Endocrine Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.2SMAD4, PTHLH, SST, SSTR2, EGFR
2MP:00053858.2EGFR, CALCA, SSTR2, PTHLH, SMAD4
3MP:00053868.1SMAD4, PTHLH, SST, SSTR2, CALCA, NCAM1
4MP:00028738.0SMAD4, SST, SYP, CALCA, EGFR
5MP:00053767.6SMAD4, PTHLH, SSTR5, SST, SSTR2, CALCA
6MP:00053787.3SMAD4, PTHLH, SSTR5, SST, NCAM1, EGFR
7MP:00036316.5EGFR, SMAD4, PTHLH, PALLD, SST, SSTR2

Publications for Pancreatic Endocrine Carcinoma

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53PubMed
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Articles related to Pancreatic Endocrine Carcinoma:

(show all 16)
idTitleAuthorsYear
1
Palladin is a marker of liver metastasis in primary pancreatic endocrine carcinomas. (21868544)
2011
2
Phase II study of first-line FOLFIRI for progressive metastatic well-differentiated pancreatic endocrine carcinoma. (21831734)
2011
3
Pancreatic endocrine carcinoma protruding from the major papilla. (20144741)
2010
4
A case of multiple hepatic metastases from pancreatic endocrine carcinoma. (18573853)
2008
5
Multimodality management of a polyfunctional pancreatic endocrine carcinoma with markedly elevated serum vasoactive intestinal polypeptide and calcitonin levels. (18362846)
2008
6
Successful pancreatectomy with en-bloc resection of the celiac artery and portal vein for pancreatic endocrine carcinoma. (17629086)
2007
7
Predictive factors of efficacy of the somatostatin analogue octreotide as first line therapy for advanced pancreatic endocrine carcinoma. (17158766)
2006
8
Long-term clinical outcome of somatostatin analogues for treatment of progressive, metastatic, well-differentiated entero-pancreatic endocrine carcinoma. (16364959)
2006
9
Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas. (15920550)
2005
10
Somatostatin-producing pancreatic endocrine carcinoma presented as relapsing cholangitis -- a case report. (15849491)
2005
11
The doxorubicin-streptozotocin combination for the treatment of advanced well-differentiated pancreatic endocrine carcinoma; a judicious option? (14962717)
2004
12
Curative resection for a pancreatic endocrine carcinoma involving the portal vein. (15532841)
2004
13
Dpc4 is expressed in virtually all primary and metastatic pancreatic endocrine carcinomas. (11964045)
2002
14
Pancreatic endocrine carcinoma with multiple hormone production in a raccoon (Procyon lotor). (10213674)
1999
15
Parathyroid hormone-like peptide in pancreatic endocrine carcinoma and adenocarcinoma associated with hypercalcemia. (1322859)
1992
16
Pancreatic endocrine carcinoma with ectopic PTH-production and paraneoplastic hypercalcaemia. (3082066)
1986

Variations for Pancreatic Endocrine Carcinoma

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Expression for genes affiliated with Pancreatic Endocrine Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Endocrine Carcinoma

Search GEO for disease gene expression data for Pancreatic Endocrine Carcinoma.

Pathways for genes affiliated with Pancreatic Endocrine Carcinoma

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG
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Compounds for genes affiliated with Pancreatic Endocrine Carcinoma

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Sources:
30IUPHAR, 46Novoseek, 12DrugBank, 62Tocris Bioscience, 25HMDB, 52PharmGKB
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Compounds related to Pancreatic Endocrine Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1bim 230593010.3SSTR2, SSTR5
2[125i]tyr3 sms 201-9953010.3SSTR2, SSTR5
3bim 230603010.3SSTR5, SSTR2
4l-363,3013010.3SSTR2, SSTR5
5bim 230563010.3SSTR5, SSTR2
6boc-ate3010.2SSTR5, SSTR2
7[111in,90y]dota-oc3010.2SSTR5, SSTR2
8bim 231973010.2SSTR5, SSTR2
9bim 230233010.2SSTR2, SSTR5
10[111in,90y]dota-toc3010.2SSTR5, SSTR2
11[111in,90y]dota-lan3010.2SSTR5, SSTR2
12noc-ate3010.2SSTR5, SSTR2
13[111in,90y]dota-noc3010.2SSTR5, SSTR2
14[111in]dota-boc-ate3010.2SSTR5, SSTR2
15[111in]dota-noc3010.2SSTR2, SSTR5
16[111in]dota-noc-ate3010.1SSTR2, SSTR5
17mk-6783010.1SSTR2, SSTR5
18bim 230303010.1SSTR2, SSTR5
19tyr-3-octreotide4610.1SST, SSTR2
20som-2303010.1SSTR2, SSTR5
21srif-283010.1SSTR2, SSTR5
22[125i]ltt-srif-283010.0SSTR5, SSTR2
23[125i]tyr10-cst143010.0SSTR2, SSTR5
24srif-143010.0SSTR2, SSTR5
25pasireotide46 1210.9SSTR5, SSTR2, SST
26(1r,1s,3r/1r,1r,3s)-l-054,264629.9SST, SSTR2, SSTR5
27cyclosomatostatin629.9SSTR5, SST, SSTR2
28cyn 154806629.9SSTR2, SST, SSTR5
29vapreotide46 30 1211.9SST, SSTR5, SSTR2
30somatostatin62 2510.9SSTR2, SST, SSTR5
31bim 23627309.9SSTR2, SSTR5
32bim 23052309.9SSTR2, SSTR5
33lanreotide46 3010.9SSTR5, SSTR2, SST
34cst-17309.8SSTR2, SSTR5
35spec-t469.8SST, CALCA, SSTR2
36[125i]cgp 23996309.6SSTR2, SSTR5
37111in-pentetreotide469.2CALCA, SYP, SSTR2, SSTR5, SST
38acth469.2CALCA, SSTR2, SST, SSTR5, SYP
39octreotide46 62 30 1212.2CALCA, PTHLH, SSTR5, SSTR2, SST
40gnrh469.2NCAM1, SST, SSTR2, SMAD4
41histamine46 30 2511.0SYP, NCAM1, CALCA, SSTR2, SST
42acetylcholine46 52 30 25 1212.9CALCA, SYP, SST, NCAM1, PTHLH
43lactate468.8SMAD4, NCAM1, CALCA, SST, PTHLH
44dopamine46 30 25 1211.7CALCA, SSTR5, SST, SSTR2, SYP, NCAM1
45progesterone46 30 62 25 1212.5PTHLH, EGFR, NCAM1, SYP, SSTR2
46paraffin468.2SMAD4, PTHLH, SSTR2, SYP, NCAM1, EGFR
47tyrosine467.8SMAD4, PTHLH, SSTR5, EGFR, NCAM1, SSTR2
48estrogen467.8PTHLH, CALCA, EGFR, SMAD4, SSTR2, NCAM1
49testosterone46 62 25 1210.7SYP, SST, PTHLH, SMAD4, CALCA, NCAM1
50vegf467.4SMAD4, PTHLH, SST, SSTR2, SYP, CALCA

GO Terms for genes affiliated with Pancreatic Endocrine Carcinoma

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17Gene Ontology
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Cellular components related to Pancreatic Endocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5EGFR, CALCA, SST, PTHLH

Biological processes related to Pancreatic Endocrine Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1endoderm developmentGO:0074929.9PTHLH, SMAD4
2positive regulation of cAMP biosynthetic processGO:0308199.9CALCA, PTHLH
3adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.8CALCA, PTHLH
4G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.8SSTR5, SSTR2
5digestionGO:0075869.8SSTR2, SST
6response to heatGO:0094089.7SST, CALCA
7cellular response to estradiol stimulusGO:0713929.6EGFR, SSTR2
8positive regulation of vasodilationGO:0459099.4CALCA, EGFR
9negative regulation of protein catabolic processGO:0421779.4EGFR, SMAD4
10cell-cell signalingGO:0072679.3PTHLH, SST, SSTR2, CALCA
11negative regulation of cell proliferationGO:0082858.9SSTR2, SST, SSTR5, PTHLH, SMAD4
12axon guidanceGO:0074118.4EGFR, NCAM1, SMAD4

Molecular functions related to Pancreatic Endocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatostatin receptor activityGO:0049949.6SSTR5, SSTR2
2hormone activityGO:0051799.3CALCA, SST, PTHLH
3identical protein bindingGO:0428027.9EGFR, NCAM1, CALCA, SYP, SMAD4

Products for genes affiliated with Pancreatic Endocrine Carcinoma

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  • Antibodies
  • Proteins
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Sources for Pancreatic Endocrine Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet