MCID: PNC008
MIFTS: 52

Pancreatic Endocrine Carcinoma malady

Cancer diseases, Neuronal diseases, Endocrine diseases categories
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Summaries for Pancreatic Endocrine Carcinoma

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Disease Ontology:8 An islet cell tumor that has material basis in epithelial cells.

MalaCards based summary: Pancreatic Endocrine Carcinoma, also known as malignant neoplasm of islets of langerhans, is related to islet cell tumor and neuroendocrine carcinoma. An important gene associated with Pancreatic Endocrine Carcinoma is SSTR5 (somatostatin receptor 5), and among its related pathways are Signal transduction by L1 and Peptide ligand-binding receptors. The drug dacarbazine and the compounds bim 23059 and [125i]tyr3 sms 201-995 have been mentioned in the context of this disorder. Affiliated tissues include pancreas and liver, and related mouse phenotypes are digestive/alimentary and cardiovascular system.

Aliases & Classifications for Pancreatic Endocrine Carcinoma

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Pancreatic Endocrine Carcinoma, Aliases & Descriptions:

Name: Pancreatic Endocrine Carcinoma 8 62
Malignant Neoplasm of Islets of Langerhans 8 62
Pancreatic Neuroendocrine Carcinoma 8 62
 
Carcinoma of Endocrine Pancreas 8 62
Islet Cell Carcinoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases, Endocrine diseases


External Ids:

Disease Ontology8 DOID:1798
NCIt39 C3770
MeSH34 D018273
ICD9CM27 157.4

Related Diseases for Pancreatic Endocrine Carcinoma

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Diseases related to Pancreatic Endocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1islet cell tumor31.3HNRNPCL1
2neuroendocrine carcinoma30.9NCAM1, CALCA, SYP, SST
3pancreatic islet cell tumors30.7SST, PTHLH
4primary hyperparathyroidism30.6PTHLH, CALCA
5hyperparathyroidism30.5CALCA, PTHLH
6neuroendocrine tumor30.5SST, SSTR2, CALCA
7cushing's syndrome30.4SST, SYP, CALCA
8somatostatinoma30.4SST, SSTR2, CALCA
9hypercalcemia30.3PTHLH, CALCA
10adenocarcinoma29.1SMAD4, PTHLH, SST, SSTR2, SYP, NCAM1
11pancreatitis10.7
12subependymal giant cell astrocytoma10.5SYP
13cowden disease10.4SMAD4
14giant cell glioblastoma10.4EGFR
15osteomalacia10.3CALCA, PTHLH
16endocrine gland cancer10.3SST, SYP
17pseudohypoparathyroidism10.3CALCA, PTHLH
18zollinger-ellison syndrome10.3
19parathyroid adenoma10.3PTHLH, CALCA
20wdha syndrome10.3SST, CALCA
21hypoparathyroidism10.3PTHLH, CALCA
22apudoma10.3SST, CALCA
23hypophosphatemia10.3PTHLH, CALCA
24hyperprolactinemia10.3PTHLH, SST
25secondary hyperparathyroidism of renal origin10.3PTHLH, CALCA
26epithelial-myoepithelial carcinoma10.3PTHLH, SMAD4
27osteoporosis, postmenopausal10.3PTHLH, CALCA
28vipoma10.2SMAD4, SST
29thyroid cancer, anaplastic10.2PTHLH, CALCA
30neuroectodermal tumor10.2SYP, NCAM1
31adenosquamous carcinoma10.2PTHLH, EGFR
32brain cancer10.2SYP, EGFR
33neuroblastoma10.2NCAM1, SYP
34tubular adenocarcinoma10.2SYP, NCAM1
35glucagonoma10.2SSTR5, SST, SSTR2
36biliary tract neoplasm10.2SMAD4, EGFR
37acromegaly10.2SSTR2, SST, SSTR5
38mucoepidermoid carcinoma10.2CALCA, EGFR
39ganglioneuroma10.2SYP, NCAM1
40tongue squamous cell carcinoma10.2PTHLH, EGFR
41breast ductal carcinoma10.2SMAD4, EGFR
42tuberous sclerosis10.2
43thyroiditis10.2
44multiple endocrine neoplasia10.2
45endotheliitis10.2
46adrenocortical carcinoma10.2SMAD4, SYP
47hirschsprung's disease10.2NCAM1, SYP
48hyperthyroxinemia10.1
49pancreatic cholera10.1
50diabetic ketoacidosis10.1

Graphical network of the top 20 diseases related to Pancreatic Endocrine Carcinoma:



Diseases related to pancreatic endocrine carcinoma

Symptoms for Pancreatic Endocrine Carcinoma

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Drugs & Therapeutics for Pancreatic Endocrine Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Pancreatic Endocrine Carcinoma

Search NIH Clinical Center for Pancreatic Endocrine Carcinoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Pancreatic Endocrine Carcinoma

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Anatomical Context for Pancreatic Endocrine Carcinoma

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MalaCards organs/tissues related to Pancreatic Endocrine Carcinoma:

32
Pancreas, Liver

Animal Models for Pancreatic Endocrine Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Pancreatic Endocrine Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.2SMAD4, PTHLH, SST, SSTR2, EGFR
2MP:00053858.2EGFR, CALCA, SSTR2, PTHLH, SMAD4
3MP:00053868.1SMAD4, PTHLH, SST, SSTR2, CALCA, NCAM1
4MP:00028738.0SMAD4, SST, SYP, CALCA, EGFR
5MP:00053767.6SMAD4, PTHLH, SSTR5, SST, SSTR2, CALCA
6MP:00053787.3SMAD4, PTHLH, SSTR5, SST, NCAM1, EGFR
7MP:00036316.5EGFR, SMAD4, PTHLH, PALLD, SST, SSTR2

Publications for Pancreatic Endocrine Carcinoma

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Articles related to Pancreatic Endocrine Carcinoma:

(show all 16)
idTitleAuthorsYear
1
Palladin is a marker of liver metastasis in primary pancreatic endocrine carcinomas. (21868544)
2011
2
Phase II study of first-line FOLFIRI for progressive metastatic well-differentiated pancreatic endocrine carcinoma. (21831734)
2011
3
Pancreatic endocrine carcinoma protruding from the major papilla. (20144741)
2010
4
A case of multiple hepatic metastases from pancreatic endocrine carcinoma. (18573853)
2008
5
Multimodality management of a polyfunctional pancreatic endocrine carcinoma with markedly elevated serum vasoactive intestinal polypeptide and calcitonin levels. (18362846)
2008
6
Successful pancreatectomy with en-bloc resection of the celiac artery and portal vein for pancreatic endocrine carcinoma. (17629086)
2007
7
Predictive factors of efficacy of the somatostatin analogue octreotide as first line therapy for advanced pancreatic endocrine carcinoma. (17158766)
2006
8
Long-term clinical outcome of somatostatin analogues for treatment of progressive, metastatic, well-differentiated entero-pancreatic endocrine carcinoma. (16364959)
2006
9
Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas. (15920550)
2005
10
Somatostatin-producing pancreatic endocrine carcinoma presented as relapsing cholangitis -- a case report. (15849491)
2005
11
The doxorubicin-streptozotocin combination for the treatment of advanced well-differentiated pancreatic endocrine carcinoma; a judicious option? (14962717)
2004
12
Curative resection for a pancreatic endocrine carcinoma involving the portal vein. (15532841)
2004
13
Dpc4 is expressed in virtually all primary and metastatic pancreatic endocrine carcinomas. (11964045)
2002
14
Pancreatic endocrine carcinoma with multiple hormone production in a raccoon (Procyon lotor). (10213674)
1999
15
Parathyroid hormone-like peptide in pancreatic endocrine carcinoma and adenocarcinoma associated with hypercalcemia. (1322859)
1992
16
Pancreatic endocrine carcinoma with ectopic PTH-production and paraneoplastic hypercalcaemia. (3082066)
1986

Variations for Pancreatic Endocrine Carcinoma

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Expression for genes affiliated with Pancreatic Endocrine Carcinoma

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Expression patterns in normal tissues for genes affiliated with Pancreatic Endocrine Carcinoma

Search GEO for disease gene expression data for Pancreatic Endocrine Carcinoma.

Pathways for genes affiliated with Pancreatic Endocrine Carcinoma

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Compounds for genes affiliated with Pancreatic Endocrine Carcinoma

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Compounds related to Pancreatic Endocrine Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1bim 230592810.3SSTR2, SSTR5
2[125i]tyr3 sms 201-9952810.3SSTR2, SSTR5
3bim 230602810.3SSTR5, SSTR2
4l-363,3012810.3SSTR2, SSTR5
5bim 230562810.3SSTR5, SSTR2
6boc-ate2810.2SSTR5, SSTR2
7[111in,90y]dota-oc2810.2SSTR5, SSTR2
8bim 231972810.2SSTR5, SSTR2
9bim 230232810.2SSTR2, SSTR5
10[111in,90y]dota-toc2810.2SSTR5, SSTR2
11[111in,90y]dota-lan2810.2SSTR5, SSTR2
12noc-ate2810.2SSTR5, SSTR2
13[111in,90y]dota-noc2810.2SSTR5, SSTR2
14[111in]dota-boc-ate2810.2SSTR5, SSTR2
15[111in]dota-noc2810.2SSTR2, SSTR5
16[111in]dota-noc-ate2810.1SSTR2, SSTR5
17mk-6782810.1SSTR2, SSTR5
18bim 230302810.1SSTR2, SSTR5
19tyr-3-octreotide4410.1SST, SSTR2
20som-2302810.1SSTR2, SSTR5
21srif-282810.1SSTR2, SSTR5
22[125i]ltt-srif-282810.0SSTR5, SSTR2
23[125i]tyr10-cst142810.0SSTR2, SSTR5
24srif-142810.0SSTR2, SSTR5
25pasireotide44 1110.9SSTR5, SSTR2, SST
26(1r,1s,3r/1r,1r,3s)-l-054,264619.9SST, SSTR2, SSTR5
27cyclosomatostatin619.9SSTR5, SST, SSTR2
28cyn 154806619.9SSTR2, SST, SSTR5
29vapreotide44 28 1111.9SST, SSTR5, SSTR2
30somatostatin61 2410.9SSTR2, SST, SSTR5
31bim 23627289.9SSTR2, SSTR5
32bim 23052289.9SSTR2, SSTR5
33lanreotide44 2810.9SSTR5, SSTR2, SST
34cst-17289.8SSTR2, SSTR5
35spec-t449.8SST, CALCA, SSTR2
36[125i]cgp 23996289.6SSTR2, SSTR5
37111in-pentetreotide449.2CALCA, SYP, SSTR2, SSTR5, SST
38acth449.2CALCA, SSTR2, SST, SSTR5, SYP
39octreotide44 61 28 1112.2CALCA, PTHLH, SSTR5, SSTR2, SST
40gnrh449.2NCAM1, SST, SSTR2, SMAD4
41histamine44 28 2411.0SYP, NCAM1, CALCA, SSTR2, SST
42acetylcholine44 50 28 24 1112.9CALCA, SYP, SST, NCAM1, PTHLH
43lactate448.8SMAD4, NCAM1, CALCA, SST, PTHLH
44dopamine44 28 24 1111.7CALCA, SSTR5, SST, SSTR2, SYP, NCAM1
45progesterone44 28 61 24 1112.5PTHLH, EGFR, NCAM1, SYP, SSTR2
46paraffin448.2SMAD4, PTHLH, SSTR2, SYP, NCAM1, EGFR
47tyrosine447.8SMAD4, PTHLH, SSTR5, EGFR, NCAM1, SSTR2
48estrogen447.8PTHLH, CALCA, EGFR, SMAD4, SSTR2, NCAM1
49testosterone44 61 24 1110.7SYP, SST, PTHLH, SMAD4, CALCA, NCAM1
50vegf447.4SMAD4, PTHLH, SST, SSTR2, SYP, CALCA

GO Terms for genes affiliated with Pancreatic Endocrine Carcinoma

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Cellular components related to Pancreatic Endocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5EGFR, CALCA, SST, PTHLH

Biological processes related to Pancreatic Endocrine Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1endoderm developmentGO:0074929.9PTHLH, SMAD4
2positive regulation of cAMP biosynthetic processGO:0308199.9CALCA, PTHLH
3adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.8CALCA, PTHLH
4G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.8SSTR5, SSTR2
5digestionGO:0075869.8SSTR2, SST
6response to heatGO:0094089.7SST, CALCA
7cellular response to estradiol stimulusGO:0713929.6EGFR, SSTR2
8positive regulation of vasodilationGO:0459099.4CALCA, EGFR
9negative regulation of protein catabolic processGO:0421779.4EGFR, SMAD4
10cell-cell signalingGO:0072679.3PTHLH, SST, SSTR2, CALCA
11negative regulation of cell proliferationGO:0082858.9SSTR2, SST, SSTR5, PTHLH, SMAD4
12axon guidanceGO:0074118.4EGFR, NCAM1, SMAD4

Molecular functions related to Pancreatic Endocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatostatin receptor activityGO:0049949.6SSTR5, SSTR2
2hormone activityGO:0051799.3CALCA, SST, PTHLH
3identical protein bindingGO:0428027.9EGFR, NCAM1, CALCA, SYP, SMAD4

Products for genes affiliated with Pancreatic Endocrine Carcinoma

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Sources for Pancreatic Endocrine Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet