MCID: PNC008
MIFTS: 44

Pancreatic Endocrine Carcinoma malady

Neuronal diseases, Endocrine diseases, Cancer diseases categories

Aliases & Classifications for Pancreatic Endocrine Carcinoma

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Pancreatic Endocrine Carcinoma, Aliases & Descriptions:

Name: Pancreatic Endocrine Carcinoma 9 11 60
Malignant Neoplasm of Islets of Langerhans 9
Pancreatic Neuroendocrine Carcinoma 9
 
Carcinoma of Endocrine Pancreas 9
Islet Cell Carcinoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases, Endocrine diseases


External Ids:

Disease Ontology9 DOID:1798
MeSH33 D018273
NCIt38 C3770
ICD9CM27 157.4

Summaries for Pancreatic Endocrine Carcinoma

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Disease Ontology:9 An islet cell tumor that has material basis in epithelial cells.

MalaCards based summary: Pancreatic Endocrine Carcinoma, also known as malignant neoplasm of islets of langerhans, is related to primary hyperparathyroidism and islet cell tumor. An important gene associated with Pancreatic Endocrine Carcinoma is SSTR5 (somatostatin receptor 5), and among its related pathways are Signal transduction by L1 and Peptide ligand-binding receptors. The drug dacarbazine and the compounds bim 23059 and [125i]tyr3 sms 201-995 have been mentioned in the context of this disorder. Affiliated tissues include pancreas and liver, and related mouse phenotypes are digestive/alimentary and cardiovascular system.

Related Diseases for Pancreatic Endocrine Carcinoma

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Diseases related to Pancreatic Endocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1primary hyperparathyroidism30.6PTHLH, CALCA
2islet cell tumor30.6SST, PTHLH
3hyperparathyroidism30.5CALCA, PTHLH
4neuroendocrine tumor30.4SST, SSTR2, CALCA
5cushing's syndrome30.4SST, SYP, CALCA
6somatostatinoma30.4SST, SSTR2, CALCA
7hypercalcemia30.3PTHLH, CALCA
8adenocarcinoma29.1SMAD4, PTHLH, SST, SSTR2, SYP, NCAM1
9neuroendocrine carcinoma10.7
10pancreatitis10.7
11subependymal giant cell astrocytoma10.5SYP
12cowden disease10.4SMAD4
13giant cell glioblastoma10.4EGFR
14osteomalacia10.3CALCA, PTHLH
15zollinger-ellison syndrome10.3
16endocrine gland cancer10.3SST, SYP
17pseudohypoparathyroidism10.3CALCA, PTHLH
18marchiafava bignami disease10.3CALCA, PTHLH
19parathyroid adenoma10.3PTHLH, CALCA
20vipoma10.3SST, CALCA
21apudoma10.3SST, CALCA
22hypoparathyroidism10.3PTHLH, CALCA
23hypophosphatemia10.3PTHLH, CALCA
24hyperprolactinemia10.3PTHLH, SST
25secondary hyperparathyroidism of renal origin10.3PTHLH, CALCA
26clear cell adenocarcinoma10.3PTHLH, SMAD4
27osteoporosis10.2PTHLH, CALCA
28thyroid cancer, anaplastic10.2PTHLH, CALCA
29neuroectodermal tumor10.2SYP, NCAM1
30adenosquamous carcinoma10.2PTHLH, EGFR
31brain cancer10.2SYP, EGFR
32neuroblastoma10.2NCAM1, SYP
33tubular adenocarcinoma10.2SYP, NCAM1
34glucagonoma10.2SSTR5, SST, SSTR2
35biliary tract neoplasm10.2SMAD4, EGFR
36acromegaly10.2SSTR2, SST, SSTR5
37mucoepidermoid carcinoma10.2CALCA, EGFR
38ganglioneuroma10.2SYP, NCAM1
39tuberous sclerosis10.2
40thyroiditis10.2
41multiple endocrine neoplasia10.2
42endotheliitis10.2
43tongue squamous cell carcinoma10.2PTHLH, EGFR
44breast ductal carcinoma10.2SMAD4, EGFR
45adrenocortical carcinoma10.2SMAD4, SYP
46hirschsprung disease 110.2NCAM1, SYP
47diabetic ketoacidosis10.1
48cholera10.1
49hyperthyroxinemia10.1
50acinar cell carcinoma10.1

Graphical network of the top 20 diseases related to Pancreatic Endocrine Carcinoma:



Diseases related to pancreatic endocrine carcinoma

Symptoms for Pancreatic Endocrine Carcinoma

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Drugs & Therapeutics for Pancreatic Endocrine Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Pancreatic Endocrine Carcinoma

Search NIH Clinical Center for Pancreatic Endocrine Carcinoma

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Pancreatic Endocrine Carcinoma

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Anatomical Context for Pancreatic Endocrine Carcinoma

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MalaCards organs/tissues related to Pancreatic Endocrine Carcinoma:

31
Pancreas, Liver

Animal Models for Pancreatic Endocrine Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Pancreatic Endocrine Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.2SMAD4, PTHLH, SST, SSTR2, EGFR
2MP:00053858.2EGFR, CALCA, SSTR2, PTHLH, SMAD4
3MP:00053868.1SMAD4, PTHLH, SST, SSTR2, CALCA, NCAM1
4MP:00028738.0SMAD4, SST, SYP, CALCA, EGFR
5MP:00053767.6SMAD4, PTHLH, SSTR5, SST, SSTR2, CALCA
6MP:00053787.3SMAD4, PTHLH, SSTR5, SST, NCAM1, EGFR
7MP:00036316.5EGFR, SMAD4, PTHLH, PALLD, SST, SSTR2

Publications for Pancreatic Endocrine Carcinoma

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Articles related to Pancreatic Endocrine Carcinoma:

(show all 16)
idTitleAuthorsYear
1
Palladin is a marker of liver metastasis in primary pancreatic endocrine carcinomas. (21868544)
2011
2
Phase II study of first-line FOLFIRI for progressive metastatic well-differentiated pancreatic endocrine carcinoma. (21831734)
2011
3
Pancreatic endocrine carcinoma protruding from the major papilla. (20144741)
2010
4
A case of multiple hepatic metastases from pancreatic endocrine carcinoma. (18573853)
2008
5
Multimodality management of a polyfunctional pancreatic endocrine carcinoma with markedly elevated serum vasoactive intestinal polypeptide and calcitonin levels. (18362846)
2008
6
Successful pancreatectomy with en-bloc resection of the celiac artery and portal vein for pancreatic endocrine carcinoma. (17629086)
2007
7
Predictive factors of efficacy of the somatostatin analogue octreotide as first line therapy for advanced pancreatic endocrine carcinoma. (17158766)
2006
8
Long-term clinical outcome of somatostatin analogues for treatment of progressive, metastatic, well-differentiated entero-pancreatic endocrine carcinoma. (16364959)
2006
9
Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas. (15920550)
2005
10
Somatostatin-producing pancreatic endocrine carcinoma presented as relapsing cholangitis -- a case report. (15849491)
2005
11
The doxorubicin-streptozotocin combination for the treatment of advanced well-differentiated pancreatic endocrine carcinoma; a judicious option? (14962717)
2004
12
Curative resection for a pancreatic endocrine carcinoma involving the portal vein. (15532841)
2004
13
Dpc4 is expressed in virtually all primary and metastatic pancreatic endocrine carcinomas. (11964045)
2002
14
Pancreatic endocrine carcinoma with multiple hormone production in a raccoon (Procyon lotor). (10213674)
1999
15
Parathyroid hormone-like peptide in pancreatic endocrine carcinoma and adenocarcinoma associated with hypercalcemia. (1322859)
1992
16
Pancreatic endocrine carcinoma with ectopic PTH-production and paraneoplastic hypercalcaemia. (3082066)
1986

Variations for Pancreatic Endocrine Carcinoma

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Expression for genes affiliated with Pancreatic Endocrine Carcinoma

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Search GEO for disease gene expression data for Pancreatic Endocrine Carcinoma.

Pathways for genes affiliated with Pancreatic Endocrine Carcinoma

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Compounds for genes affiliated with Pancreatic Endocrine Carcinoma

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Compounds related to Pancreatic Endocrine Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1bim 230592810.3SSTR2, SSTR5
2[125i]tyr3 sms 201-9952810.3SSTR2, SSTR5
3bim 230602810.3SSTR5, SSTR2
4[111in]dota-noc2810.3SSTR2, SSTR5
5bim 230562810.3SSTR5, SSTR2
6boc-ate2810.2SSTR5, SSTR2
7[111in,90y]dota-oc2810.2SSTR5, SSTR2
8bim 231972810.2SSTR5, SSTR2
9l-363,3012810.2SSTR2, SSTR5
10noc-ate2810.2SSTR2, SSTR5
11[111in,90y]dota-lan2810.2SSTR2, SSTR5
12[111in,90y]dota-toc2810.2SSTR2, SSTR5
13[111in,90y]dota-noc2810.2SSTR5, SSTR2
14[111in]dota-boc-ate2810.2SSTR2, SSTR5
15bim 230232810.2SSTR2, SSTR5
16[111in]dota-noc-ate2810.1SSTR2, SSTR5
17bim 230302810.1SSTR2, SSTR5
18mk-6782810.1SSTR2, SSTR5
19tyr-3-octreotide4310.1SST, SSTR2
20som-2302810.1SSTR2, SSTR5
21cst-172810.1SSTR5, SSTR2
22bim 234542810.0SSTR2, SSTR5
23srif-282810.0SSTR5, SSTR2
24srif-142810.0SSTR5, SSTR2
25pasireotide43 1210.9SSTR5, SSTR2, SST
26(1r,1s,3r/1r,1r,3s)-l-054,264599.9SST, SSTR2, SSTR5
27cyclosomatostatin599.9SSTR5, SST, SSTR2
28cyn 154806599.9SSTR2, SST, SSTR5
29vapreotide43 28 1211.9SST, SSTR5, SSTR2
30somatostatin59 2410.9SSTR2, SST, SSTR5
31[125i]cgp 23996289.9SSTR5, SSTR2
32bim 23627289.9SSTR2, SSTR5
33lanreotide43 2810.9SSTR5, SSTR2, SST
34bim 23052289.8SSTR2, SSTR5
35spec-t439.8SST, CALCA, SSTR2
36cgp 23996289.6SSTR2, SSTR5
37111in-pentetreotide439.2CALCA, SYP, SSTR2, SSTR5, SST
38acth439.2CALCA, SSTR2, SST, SSTR5, SYP
39octreotide43 59 28 1212.2CALCA, PTHLH, SSTR5, SSTR2, SST
40gnrh439.2NCAM1, SST, SSTR2, SMAD4
41histamine43 28 2411.0SYP, NCAM1, CALCA, SSTR2, SST
42acetylcholine43 49 28 24 1212.9CALCA, SYP, SST, NCAM1, PTHLH
43lactate438.8SMAD4, NCAM1, CALCA, SST, PTHLH
44dopamine43 28 24 1211.7CALCA, SSTR5, SST, SSTR2, SYP, NCAM1
45progesterone43 28 59 24 1212.5EGFR, NCAM1, SYP, SSTR2, PTHLH
46paraffin438.2SMAD4, PTHLH, SSTR2, SYP, NCAM1, EGFR
47tyrosine437.8SMAD4, PTHLH, SSTR5, EGFR, NCAM1, SSTR2
48estrogen437.8PTHLH, CALCA, EGFR, SMAD4, SSTR2, NCAM1
49testosterone43 59 24 1210.7SYP, SST, PTHLH, SMAD4, CALCA, NCAM1
50vegf437.4SMAD4, PTHLH, SST, SSTR2, SYP, CALCA

GO Terms for genes affiliated with Pancreatic Endocrine Carcinoma

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Cellular components related to Pancreatic Endocrine Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5EGFR, CALCA, SST, PTHLH

Biological processes related to Pancreatic Endocrine Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1endoderm developmentGO:00074929.9PTHLH, SMAD4
2positive regulation of cAMP biosynthetic processGO:00308199.9CALCA, PTHLH
3adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.8CALCA, PTHLH
4G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.8SSTR5, SSTR2
5digestionGO:00075869.8SSTR2, SST
6response to heatGO:00094089.7SST, CALCA
7cellular response to estradiol stimulusGO:00713929.6EGFR, SSTR2
8positive regulation of vasodilationGO:00459099.4CALCA, EGFR
9negative regulation of protein catabolic processGO:00421779.4EGFR, SMAD4
10cell-cell signalingGO:00072679.3PTHLH, SST, SSTR2, CALCA
11negative regulation of cell proliferationGO:00082858.9SSTR2, SST, SSTR5, PTHLH, SMAD4
12axon guidanceGO:00074118.4EGFR, NCAM1, SMAD4

Molecular functions related to Pancreatic Endocrine Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1somatostatin receptor activityGO:00049949.6SSTR5, SSTR2
2hormone activityGO:00051799.3CALCA, SST, PTHLH
3identical protein bindingGO:00428027.9EGFR, NCAM1, CALCA, SYP, SMAD4

Products for genes affiliated with Pancreatic Endocrine Carcinoma

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  • Antibodies
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  • Kits and Assays

Sources for Pancreatic Endocrine Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet