MCID: PNC008
MIFTS: 44

Pancreatic Endocrine Carcinoma malady

Neuronal diseases, Endocrine diseases, Cancer diseases categories

Aliases & Classifications for Pancreatic Endocrine Carcinoma

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Aliases & Descriptions for Pancreatic Endocrine Carcinoma:

Name: Pancreatic Endocrine Carcinoma 8 10 61
Malignant Neoplasm of Islets of Langerhans 8
Pancreatic Neuroendocrine Carcinoma 8
 
Carcinoma of Endocrine Pancreas 8
Islet Cell Carcinoma 8


Classifications:



External Ids:

Disease Ontology8 DOID:1798
MeSH33 D018273
NCIt39 C3770
ICD9CM27 157.4

Summaries for Pancreatic Endocrine Carcinoma

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Disease Ontology:8 An islet cell tumor that has material basis in epithelial cells.

MalaCards based summary: Pancreatic Endocrine Carcinoma, also known as malignant neoplasm of islets of langerhans, is related to primary hyperparathyroidism and islet cell tumor. An important gene associated with Pancreatic Endocrine Carcinoma is SSTR5 (somatostatin receptor 5), and among its related pathways are Signal transduction by L1 and Peptide ligand-binding receptors. The drug dacarbazine and the compounds bim 23060 and [125i]tyr3 sms 201-995 have been mentioned in the context of this disorder. Affiliated tissues include pancreas and liver, and related mouse phenotypes are digestive/alimentary and cardiovascular system.

Related Diseases for Pancreatic Endocrine Carcinoma

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Diseases related to Pancreatic Endocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1primary hyperparathyroidism30.6PTHLH, CALCA
2islet cell tumor30.6SST, PTHLH
3hyperparathyroidism30.5CALCA, PTHLH
4neuroendocrine tumor30.4SST, SSTR2, CALCA
5cushing's syndrome30.4SST, SYP, CALCA
6somatostatinoma30.4SST, SSTR2, CALCA
7hypercalcemia30.3PTHLH, CALCA
8adenocarcinoma29.1SMAD4, PTHLH, SST, SSTR2, SYP, NCAM1
9neuroendocrine carcinoma10.7
10pancreatitis10.7
11subependymal giant cell astrocytoma10.5SYP
12cowden disease10.4SMAD4
13giant cell glioblastoma10.4EGFR
14osteomalacia10.3CALCA, PTHLH
15zollinger-ellison syndrome10.3
16endocrine gland cancer10.3SST, SYP
17pseudohypoparathyroidism10.3CALCA, PTHLH
18marchiafava bignami disease10.3CALCA, PTHLH
19parathyroid adenoma10.3PTHLH, CALCA
20vipoma10.3SST, CALCA
21apudoma10.3SST, CALCA
22hypoparathyroidism10.3PTHLH, CALCA
23hypophosphatemia10.3PTHLH, CALCA
24hyperprolactinemia10.3PTHLH, SST
25secondary hyperparathyroidism of renal origin10.3PTHLH, CALCA
26clear cell adenocarcinoma10.3PTHLH, SMAD4
27osteoporosis10.2PTHLH, CALCA
28thyroid cancer, anaplastic10.2PTHLH, CALCA
29neuroectodermal tumor10.2SYP, NCAM1
30adenosquamous carcinoma10.2PTHLH, EGFR
31brain cancer10.2SYP, EGFR
32neuroblastoma10.2NCAM1, SYP
33tubular adenocarcinoma10.2SYP, NCAM1
34glucagonoma10.2SSTR5, SST, SSTR2
35biliary tract neoplasm10.2SMAD4, EGFR
36acromegaly10.2SSTR2, SST, SSTR5
37mucoepidermoid carcinoma10.2CALCA, EGFR
38ganglioneuroma10.2SYP, NCAM1
39tuberous sclerosis10.2
40thyroiditis10.2
41multiple endocrine neoplasia10.2
42endotheliitis10.2
43tongue squamous cell carcinoma10.2PTHLH, EGFR
44breast ductal carcinoma10.2SMAD4, EGFR
45adrenocortical carcinoma10.2SMAD4, SYP
46hirschsprung disease 110.2NCAM1, SYP
47diabetic ketoacidosis10.1
48cholera10.1
49hyperthyroxinemia10.1
50acinar cell carcinoma10.1

Graphical network of the top 20 diseases related to Pancreatic Endocrine Carcinoma:



Diseases related to pancreatic endocrine carcinoma

Symptoms for Pancreatic Endocrine Carcinoma

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Drugs & Therapeutics for Pancreatic Endocrine Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Pancreatic Endocrine Carcinoma

Search NIH Clinical Center for Pancreatic Endocrine Carcinoma

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Pancreatic Endocrine Carcinoma

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Anatomical Context for Pancreatic Endocrine Carcinoma

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MalaCards organs/tissues related to Pancreatic Endocrine Carcinoma:

31
Pancreas, Liver

Animal Models for Pancreatic Endocrine Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Pancreatic Endocrine Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.2SMAD4, PTHLH, SST, SSTR2, EGFR
2MP:00053858.2EGFR, CALCA, SSTR2, PTHLH, SMAD4
3MP:00053868.1SMAD4, PTHLH, SST, SSTR2, CALCA, NCAM1
4MP:00028738.0SMAD4, SST, SYP, CALCA, EGFR
5MP:00053767.6SMAD4, PTHLH, SSTR5, SST, SSTR2, CALCA
6MP:00053787.3SMAD4, PTHLH, SSTR5, SST, NCAM1, EGFR
7MP:00036316.5EGFR, SMAD4, PTHLH, PALLD, SST, SSTR2

Publications for Pancreatic Endocrine Carcinoma

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Articles related to Pancreatic Endocrine Carcinoma:

(show all 16)
idTitleAuthorsYear
1
Palladin is a marker of liver metastasis in primary pancreatic endocrine carcinomas. (21868544)
2011
2
Phase II study of first-line FOLFIRI for progressive metastatic well-differentiated pancreatic endocrine carcinoma. (21831734)
2011
3
Pancreatic endocrine carcinoma protruding from the major papilla. (20144741)
2010
4
A case of multiple hepatic metastases from pancreatic endocrine carcinoma. (18573853)
2008
5
Multimodality management of a polyfunctional pancreatic endocrine carcinoma with markedly elevated serum vasoactive intestinal polypeptide and calcitonin levels. (18362846)
2008
6
Successful pancreatectomy with en-bloc resection of the celiac artery and portal vein for pancreatic endocrine carcinoma. (17629086)
2007
7
Predictive factors of efficacy of the somatostatin analogue octreotide as first line therapy for advanced pancreatic endocrine carcinoma. (17158766)
2006
8
Long-term clinical outcome of somatostatin analogues for treatment of progressive, metastatic, well-differentiated entero-pancreatic endocrine carcinoma. (16364959)
2006
9
Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas. (15920550)
2005
10
Somatostatin-producing pancreatic endocrine carcinoma presented as relapsing cholangitis -- a case report. (15849491)
2005
11
The doxorubicin-streptozotocin combination for the treatment of advanced well-differentiated pancreatic endocrine carcinoma; a judicious option? (14962717)
2004
12
Curative resection for a pancreatic endocrine carcinoma involving the portal vein. (15532841)
2004
13
Dpc4 is expressed in virtually all primary and metastatic pancreatic endocrine carcinomas. (11964045)
2002
14
Pancreatic endocrine carcinoma with multiple hormone production in a raccoon (Procyon lotor). (10213674)
1999
15
Parathyroid hormone-like peptide in pancreatic endocrine carcinoma and adenocarcinoma associated with hypercalcemia. (1322859)
1992
16
Pancreatic endocrine carcinoma with ectopic PTH-production and paraneoplastic hypercalcaemia. (3082066)
1986

Variations for Pancreatic Endocrine Carcinoma

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Expression for genes affiliated with Pancreatic Endocrine Carcinoma

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Search GEO for disease gene expression data for Pancreatic Endocrine Carcinoma.

Pathways for genes affiliated with Pancreatic Endocrine Carcinoma

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Compounds for genes affiliated with Pancreatic Endocrine Carcinoma

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Compounds related to Pancreatic Endocrine Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1bim 230602810.3SSTR5, SSTR2
2[125i]tyr3 sms 201-9952810.3SSTR5, SSTR2
3bim 230592810.3SSTR5, SSTR2
4l-363,3012810.3SSTR2, SSTR5
5bim 230562810.3SSTR5, SSTR2
6boc-ate2810.2SSTR5, SSTR2
7[111in,90y]dota-oc2810.2SSTR5, SSTR2
8bim 231972810.2SSTR5, SSTR2
9[111in,90y]dota-toc2810.2SSTR5, SSTR2
10[111in,90y]dota-lan2810.2SSTR5, SSTR2
11noc-ate2810.2SSTR5, SSTR2
12[111in]dota-noc2810.2SSTR2, SSTR5
13[111in,90y]dota-noc2810.2SSTR5, SSTR2
14[111in]dota-boc-ate2810.2SSTR2, SSTR5
15bim 230232810.2SSTR2, SSTR5
16[111in]dota-noc-ate2810.1SSTR2, SSTR5
17mk-6782810.1SSTR2, SSTR5
18bim 230302810.1SSTR5, SSTR2
19tyr-3-octreotide4410.1SSTR2, SST
20som-2302810.1SSTR2, SSTR5
21[d-tyr8]cyn 1548062810.1SSTR5, SSTR2
22[125i]ltt-srif-282810.0SSTR2, SSTR5
23[125i]tyr10-cst142810.0SSTR2, SSTR5
24srif-142810.0SSTR2, SSTR5
25pasireotide44 1110.9SSTR5, SSTR2, SST
26(1r,1s,3r/1r,1r,3s)-l-054,264609.9SST, SSTR2, SSTR5
27cyclosomatostatin609.9SSTR5, SST, SSTR2
28cyn 154806609.9SSTR2, SST, SSTR5
29somatostatin60 2410.9SSTR2, SST, SSTR5
30vapreotide44 28 1111.9SSTR2, SST, SSTR5
31srif-28289.9SSTR2, SSTR5
32l-362,855289.9SSTR2, SSTR5
33lanreotide44 2810.9SST, SSTR2, SSTR5
34cst-17289.8SSTR2, SSTR5
35spec-t449.8SSTR2, SST, CALCA
36[l-tyr8]cyn 154806289.6SSTR5, SSTR2
37111in-pentetreotide449.2CALCA, SYP, SSTR2, SSTR5, SST
38acth449.2CALCA, SSTR2, SST, SSTR5, SYP
39octreotide44 60 28 1112.2CALCA, PTHLH, SSTR5, SSTR2, SST
40gnrh449.2SST, SMAD4, NCAM1, SSTR2
41histamine44 28 2411.0NCAM1, CALCA, SYP, SSTR2, SST
42acetylcholine44 50 28 24 1112.9NCAM1, CALCA, PTHLH, SST, SYP
43lactate448.8PTHLH, SMAD4, SST, CALCA, NCAM1
44dopamine44 28 24 1111.7CALCA, SSTR5, SST, SSTR2, SYP, NCAM1
45progesterone44 28 60 24 1112.5NCAM1, EGFR, PTHLH, SSTR2, SYP
46paraffin448.2SMAD4, PTHLH, SSTR2, SYP, NCAM1, EGFR
47tyrosine447.8SSTR2, SMAD4, PTHLH, SSTR5, NCAM1, SYP
48estrogen447.8PTHLH, NCAM1, CALCA, SYP, EGFR, SSTR2
49testosterone44 60 24 1110.7SYP, SST, PTHLH, SMAD4, CALCA, NCAM1
50vegf447.4SMAD4, PTHLH, SST, SSTR2, SYP, CALCA

GO Terms for genes affiliated with Pancreatic Endocrine Carcinoma

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Cellular components related to Pancreatic Endocrine Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5EGFR, CALCA, SST, PTHLH

Biological processes related to Pancreatic Endocrine Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1endoderm developmentGO:00074929.9PTHLH, SMAD4
2positive regulation of cAMP biosynthetic processGO:00308199.9CALCA, PTHLH
3adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.8CALCA, PTHLH
4G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.8SSTR5, SSTR2
5digestionGO:00075869.8SSTR2, SST
6response to heatGO:00094089.7SST, CALCA
7cellular response to estradiol stimulusGO:00713929.6EGFR, SSTR2
8positive regulation of vasodilationGO:00459099.4CALCA, EGFR
9negative regulation of protein catabolic processGO:00421779.4EGFR, SMAD4
10cell-cell signalingGO:00072679.3PTHLH, SST, SSTR2, CALCA
11negative regulation of cell proliferationGO:00082858.9SSTR2, SST, SSTR5, PTHLH, SMAD4
12axon guidanceGO:00074118.4EGFR, NCAM1, SMAD4

Molecular functions related to Pancreatic Endocrine Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1somatostatin receptor activityGO:00049949.6SSTR5, SSTR2
2hormone activityGO:00051799.3CALCA, SST, PTHLH
3identical protein bindingGO:00428027.9EGFR, NCAM1, CALCA, SYP, SMAD4

Sources for Pancreatic Endocrine Carcinoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet