MCID: PNC008
MIFTS: 49

Pancreatic Endocrine Carcinoma malady

Cancer diseases, Neuronal diseases, Endocrine diseases categories

Summaries for Pancreatic Endocrine Carcinoma

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32MalaCards
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MalaCards: Pancreatic Endocrine Carcinoma, also known as malignant neoplasm of islets of langerhans, any part of pancreas, is related to pancreatitis and cushing's syndrome. An important gene associated with Pancreatic Endocrine Carcinoma is SSTR5 (somatostatin receptor 5), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The drug dacarbazine and the compounds [125i]tyr3 sms 201-995 and bim 23060 have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and breast, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Aliases & Classifications for Pancreatic Endocrine Carcinoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases, Endocrine diseases


Aliases & Descriptions:

pancreatic endocrine carcinoma 8 60
malignant neoplasm of islets of langerhans, any part of pancreas 8
malignant neoplasm of islets of langerhans 8
malignant neoplasm of endocrine pancreas 60
malignant tumor of islets of langerhans 8
malignant tumor of endocrine pancreas 8
malignant pancreatic endocrine tumor 8
pancreatic neuroendocrine carcinoma 8
carcinoma of endocrine pancreas 8
endocrine pancreas cancer 8
islet cell carcinoma 8


External Ids:

Disease Ontology8 DOID:1798, DOID:10165
NCIt39 C3770
ICD9CM27 157.4
MeSH34 D018273
ICD1025 C25.4

Related Diseases for Pancreatic Endocrine Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Pancreatic Endocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.0SMAD4, SST
2cushing's syndrome30.3CALCA, SYP, SST
3acromegaly30.2SST, SSTR2, SSTR5
4prolactinoma30.2NCAM1, SSTR5, SSTR2, SST, PTHLH
5thyroiditis30.1CALCA
6pancreatic cancer30.1EGFR, NCAM1, SSTR2, SST, SMAD4
7hyperparathyroidism30.1CALCA, PTHLH
8ductal carcinoma in situ30.1EGFR
9primary hyperparathyroidism30.1CALCA, PTHLH
10neuroendocrine carcinoma30.1CALCA, NCAM1, SYP, SST
11neuroendocrine tumor30.1CALCA, NCAM1, SYP, SSTR2, SST
12hypercalcemia30.1PTHLH, CALCA
13islet cell tumor30.1PTHLH, SST
14somatostatinoma30.1SST, SSTR2, CALCA
15pancreatic islet cell tumors30.1PTHLH, SST, SYP, CALCA
16adenocarcinoma30.0EGFR, NCAM1, SYP, SSTR2, SST, PTHLH
17zollinger-ellison syndrome10.2
18diabetes insipidus10.2
19tuberous sclerosis10.1
20hyperthyroxinemia10.1
21cholera10.1
22diabetic ketoacidosis10.1
23pancreatic somatostatinoma10.1
24adenocarcinoma in situ10.1
25pancreatic cholera10.1
26acinar cell carcinoma10.1
27dermatitis10.1
28in situ carcinoma10.1
29pancreas adenocarcinoma10.1
30pneumonia10.1
31parathyroid carcinoma10.1
32hepatitis a10.1
33cholangitis10.1
34hepatitis10.1
35melanoma10.0SSTR2
36sarcoma10.0SSTR2
37thymus cancer10.0SYP
38rhabdoid tumor10.0SYP
39hemangioblastoma10.0SYP
40neurofibroma10.0SYP
41paraneoplastic syndromes10.0PTHLH
42schizophrenia10.0SYP
43hypertension10.0CALCA
44subependymal giant cell astrocytoma10.0SYP
45phaeochromocytoma10.0CALCA
46teratocarcinoma10.0SYP
47gastritis10.0SST
48galactosemia10.0SST
49ganglioneuroblastoma10.0SYP
50hepatocellular carcinoma10.0SSTR2, SMAD4

Graphical network of the top 20 diseases related to Pancreatic Endocrine Carcinoma:



Diseases related to pancreatic endocrine carcinoma

Clinical Features for Pancreatic Endocrine Carcinoma

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Drugs & Therapeutics for Pancreatic Endocrine Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pancreatic Endocrine Carcinoma

Drug clinical trials:

Search ClinicalTrials for Pancreatic Endocrine Carcinoma

Search NIH Clinical Center for Pancreatic Endocrine Carcinoma

Search CenterWatch for Pancreatic Endocrine Carcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pancreatic Endocrine Carcinoma

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Anatomical Context for Pancreatic Endocrine Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Pancreatic Endocrine Carcinoma:

32
Pancreas, Liver, Breast

Animal Models for Pancreatic Endocrine Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pancreatic Endocrine Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.8SSTR5, CALCA
2MP:00036318.9PALLD, SYP, SSTR2
3MP:00053818.1SMAD4, EGFR, SSTR2, SST, PTHLH

Publications for Pancreatic Endocrine Carcinoma

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50PubMed
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Articles related to Pancreatic Endocrine Carcinoma:

(show all 31)
idTitleAuthorsYear
1
IMP3, NESP55, TTF-1 and CDX2 serve as an immunohistochemical panel in the distinction among small-cell carcinoma, gastrointestinal carcinoid, and pancreatic endocrine tumor metastasized to the liver. (22495359)
2012
2
Palladin is a marker of liver metastasis in primary pancreatic endocrine carcinomas. (21868544)
2011
3
Phase II study of first-line FOLFIRI for progressive metastatic well-differentiated pancreatic endocrine carcinoma. (21831734)
2011
4
Pancreatic endocrine carcinoma protruding from the major papilla. (20144741)
2010
5
Pancreatic acinar cell carcinomas with prominent ductal differentiation: Mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma. (20182344)
2010
6
Pancreatic-type mixed acinar-endocrine carcinoma with alpha-fetoprotein production arising from the stomach: a report of an extremely rare case. (19784744)
2009
7
Metastatic merkel cell carcinoma of the pancreas mimicking primary pancreatic endocrine tumor diagnosed by endoscopic ultrasound-guided fine needle aspiration cytology: a case report. (19365981)
2009
8
A case of multiple hepatic metastases from pancreatic endocrine carcinoma. (18573853)
2008
9
Fast-growing pancreatic neuroendocrine carcinoma in a patient with multiple endocrine neoplasia type 1: a case report. (19017391)
2008
10
Multimodality management of a polyfunctional pancreatic endocrine carcinoma with markedly elevated serum vasoactive intestinal polypeptide and calcitonin levels. (18362846)
2008
11
Mixed ductal-endocrine carcinoma of the pancreas with synchronous papillary carcinoma-in-situ of the common bile duct: a case report and literature review--synchronous pancreatic and bile duct tumors. (18453301)
2008
12
Successful pancreatectomy with en-bloc resection of the celiac artery and portal vein for pancreatic endocrine carcinoma. (17629086)
2007
13
Predictive factors of efficacy of the somatostatin analogue octreotide as first line therapy for advanced pancreatic endocrine carcinoma. (17158766)
2006
14
Single case of renal cell carcinoma and endocrine pancreatic head cancer occurring with von Hippel-Lindau disease. (16547682)
2006
15
Long-term clinical outcome of somatostatin analogues for treatment of progressive, metastatic, well-differentiated entero-pancreatic endocrine carcinoma. (16364959)
2006
16
Intraductal spread by metastatic islet cell tumor (well-differentiated pancreatic endocrine neoplasm) involving the breast of a child, mimicking a primary mammary carcinoma. (16819337)
2006
17
Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas. (15920550)
2005
18
Somatostatin-producing pancreatic endocrine carcinoma presented as relapsing cholangitis -- a case report. (15849491)
2005
19
Alteration of the K-ras and p16/CDKN2 gene in endocrine pancreatic carcinomas]. (15148814)
2004
20
The doxorubicin-streptozotocin combination for the treatment of advanced well-differentiated pancreatic endocrine carcinoma; a judicious option? (14962717)
2004
21
Curative resection for a pancreatic endocrine carcinoma involving the portal vein. (15532841)
2004
22
Dpc4 is expressed in virtually all primary and metastatic pancreatic endocrine carcinomas. (11964045)
2002
23
Endocrine and intermediate cells in pancreatic ductal carcinoma and in chronic pancreatitis. (12533945)
2002
24
Clear cell endocrine pancreatic tumor mimicking renal cell carcinoma: a distinctive neoplasm of von Hippel-Lindau disease. (11342771)
2001
25
Pancreatic acinar cell carcinoma with endocrine differentiation: immunohistochemical and ultrastructural analyses. (11501836)
2001
26
Pancreatic endocrine carcinoma with multiple hormone production in a raccoon (Procyon lotor). (10213674)
1999
27
Endocrine cell carcinoma (carcinoid tumour) of the gallbladder producing pancreatic polypeptide and somatostatin. (9205872)
1997
28
Neuroendocrine differentiation in pancreatic duct carcinoma special emphasis on duct-endocrine cell carcinoma of the pancreas. (8950756)
1996
29
Tissue-type plasminogen activator predicts endocrine responsiveness of human pancreatic carcinoma cells. (7882277)
1995
30
Parathyroid hormone-like peptide in pancreatic endocrine carcinoma and adenocarcinoma associated with hypercalcemia. (1322859)
1992
31
Pancreatic endocrine carcinoma with ectopic PTH-production and paraneoplastic hypercalcaemia. (3082066)
1986

Genetic Variations for Pancreatic Endocrine Carcinoma

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Expression for genes affiliated with Pancreatic Endocrine Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Endocrine Carcinoma

Search GEO for disease gene expression data for Pancreatic Endocrine Carcinoma.

Pathways for genes affiliated with Pancreatic Endocrine Carcinoma

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Pancreatic Endocrine Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
8.7PTHLH, SST, SSTR2, SSTR5, CALCA
2
Hide members
7.7SMAD4, CALCA, EGFR, SSTR5, SSTR2, SST

Compounds for genes affiliated with Pancreatic Endocrine Carcinoma

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28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Pancreatic Endocrine Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1[125i]tyr3 sms 201-9952810.3SSTR5, SSTR2
2bim 230602810.3SSTR5, SSTR2
3bim 230592810.3SSTR5, SSTR2
4l-363,3012810.3SSTR2, SSTR5
5bim 230562810.3SSTR5, SSTR2
6boc-ate2810.3SSTR5, SSTR2
7[111in,90y]dota-oc2810.3SSTR5, SSTR2
8noc-ate2810.3SSTR2, SSTR5
9[111in,90y]dota-lan2810.3SSTR2, SSTR5
10[111in,90y]dota-toc2810.2SSTR2, SSTR5
11bim 231972810.2SSTR5, SSTR2
12[111in]dota-boc-ate2810.2SSTR2, SSTR5
13bim 230232810.2SSTR2, SSTR5
14[111in]dota-noc2810.2SSTR2, SSTR5
15[111in]dota-noc-ate2810.2SSTR2, SSTR5
16mk-6782810.2SSTR2, SSTR5
17[111in,90y]dota-noc2810.2SSTR5, SSTR2
18bim 230302810.2SSTR5, SSTR2
19som-2302810.1SSTR2, SSTR5
20[125i]cgp 239962810.1SSTR2, SSTR5
21bim 230522810.1SSTR2, SSTR5
22tyr-3-octreotide4410.1SST, SSTR2
23cgp 239962810.0SSTR2, SSTR5
24bim 236272810.0SSTR2, SSTR5
25cst-172810.0SSTR5, SSTR2
26srif-28289.9SSTR5, SSTR2
27[125i]ltt-srif-28289.9SSTR5, SSTR2
28pasireotide44 1110.9SSTR5, SSTR2, SST
29(1r,1s,3r/1r,1r,3s)-l-054,264599.9SSTR5, SSTR2, SST
30cyclosomatostatin599.9SSTR5, SSTR2, SST
31cyn 154806599.9SSTR5, SSTR2, SST
32vapreotide28 44 1111.9SSTR5, SSTR2, SST
33somatostatin59 2410.9SSTR5, SSTR2, SST
34lanreotide44 2810.9SSTR5, SSTR2, SST
35dopamine44 28 11 2412.8NCAM1, SSTR5, SSTR2
36srif-14289.8SSTR5, SSTR2
37spec-t449.7SST, SSTR2, CALCA
38[125i]tyr10-cst14289.6SSTR5, SSTR2
39acth449.5SST, SSTR2, SSTR5, SYP
40111in-pentetreotide449.2SST, SSTR2, SSTR5, SYP, CALCA
41gnrh449.1NCAM1, SSTR2, SST, SMAD4
42octreotide44 59 28 1112.1CALCA, SSTR5, SSTR2, SST, PTHLH
43histamine44 28 2410.9SST, SSTR2, SYP, NCAM1, CALCA
44acetylcholine44 49 28 11 2412.8CALCA, NCAM1, SYP, SST, PTHLH
45lactate448.8CALCA, NCAM1, SST, PTHLH, SMAD4
46progesterone44 59 28 11 2412.6EGFR, NCAM1, SYP, SSTR2, PTHLH
47paraffin448.4EGFR, NCAM1, SYP, SSTR2, PTHLH, SMAD4
48tyrosine448.0EGFR, NCAM1, SYP, SSTR5, SSTR2, PTHLH
49testosterone44 59 11 2410.9CALCA, EGFR, NCAM1, SYP, SST, PTHLH
50vegf447.6CALCA, EGFR, NCAM1, SYP, SSTR2, SST

GO Terms for genes affiliated with Pancreatic Endocrine Carcinoma

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16Gene Ontology
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Biological processes related to Pancreatic Endocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP biosynthetic processGO:0308199.7PTHLH, CALCA
2cellular response to estradiol stimulusGO:0713929.6SSTR2, EGFR
3endoderm developmentGO:0074929.5PTHLH, SMAD4
4negative regulation of protein catabolic processGO:0421779.4EGFR, SMAD4
5cell-cell signalingGO:0072679.0CALCA, SSTR2, SST, PTHLH
6negative regulation of cell proliferationGO:0082858.8SMAD4, PTHLH, SST, SSTR2, SSTR5

Molecular functions related to Pancreatic Endocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatostatin receptor activityGO:0049949.6SSTR5, SSTR2
2hormone activityGO:0051799.2PTHLH, SST, CALCA
3identical protein bindingGO:0428028.2SMAD4, SYP, NCAM1, EGFR, CALCA

Products for genes affiliated with Pancreatic Endocrine Carcinoma

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  • Antibodies
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Sources for Pancreatic Endocrine Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet