MCID: PNC047
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Pancreatic Endocrine Tumors malady

Gastrointestinal diseases, Endocrine diseases, Cancer diseases categories

Summaries for Pancreatic Endocrine Tumors

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63Wikipedia, 32MalaCards
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Wikipedia:63 Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous... more...

MalaCards: Pancreatic Endocrine Tumors, also known as pancreatic endocrine tumor, is related to adenoma and zollinger-ellison syndrome. An important gene associated with Pancreatic Endocrine Tumors is ST11 (suppression of tumorigenicity 11 (pancreas)), and among its related pathways are Regulation of beta-cell development and Transcription factors in neurogenesis. The compounds [125i]cgp 23996 and srif-28 have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Pancreatic Endocrine Tumors

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46OMIM, 48Orphanet, 26ICD10 via Orphanet
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Related Diseases for Pancreatic Endocrine Tumors

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17GeneCards, 18GeneDecks
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Diseases related to Pancreatic Endocrine Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.3ASCL1, GHRH, SSTR5, SSTR2, SSTR1, MEN1
2zollinger-ellison syndrome30.3GHRH, MEN1
3cushing's syndrome30.3GHRH
4gastrinoma30.1MEN1, SSTR5, SSTR1, SSTR2
5acromegaly30.1SSTR1, SSTR5, MEN1, SSTR2, GHRH
6insulinoma30.1SSTR5, SSTR1, GHRH, SSTR4, MEN1, PDX1
7prolactinoma30.1SSTR3, SSTR5, MEN1, SSTR2, SSTR4, SSTR1
8neuroendocrine tumor30.1MEN1, SSTR2, CDX2, ASCL1
9adenocarcinoma30.1MEN1, NEUROD1, CDX2, SSTR1, SSTR2, PDX1
10type 2 diabetes mellitus30.1NEUROG3, ISL1, PDX1, NEUROD1
11pancreatitis11.1
12non-functioning pancreatic endocrine tumor10.5
13cystadenoma10.3
14pancreatic endocrine carcinoma10.3
15pancreatic serous cystadenoma10.3
16islet cell tumor10.3
17pancreatic cystadenoma10.3
18functioning pancreatic endocrine tumor10.3
19microcystic adenoma10.2
20neurofibromatosis10.1
21duodenal ulcer10.1
22obstructive jaundice10.1
23tuberous sclerosis10.1
24pancreatic vasoactive intestinal peptide producing tumor10.1
25small cell carcinoma10.1
26diabetes insipidus10.1
27amyloid tumor10.1
28pancreatic gastrinoma10.1
29hypoglycemia10.1
30duodenitis10.1
31hyperinsulinemic hypoglycemia10.1
32merkel cell carcinoma10.1
33diabetes mellitus10.1
34thyroiditis10.1
35multiple endocrine neoplasia10.0MEN1
36pheochromocytoma10.0SSTR4, SSTR1, SSTR2, SSTR5, CDX2, ASCL1
37pituitary adenoma10.0GHRH, NEUROD1, SSTR2, SSTR1, SSTR3, MEN1
38pituitary tumors10.0MEN1, GHRH, SSTR5, SSTR2, SSTR1, SSTR4
39carcinoid syndrome10.0ASCL1, GHRH, SSTR3, MEN1, SSTR1, SSTR2
40prostate cancer10.0SSTR4, SSTR1, GHRH, CDX2, SSTR5, CDKN2C
41thyroid medullary carcinoma10.0SSTR5, MEN1, ASCL1, SSTR1, SSTR2
42glucagonoma10.0SSTR2, MEN1, GHRH, SSTR5, PDX1
43hepatocellular carcinoma10.0MEN1, SSTR2, CDX2, CDKN2C
44somatostatinoma10.0GHRH, SSTR2
45vipoma10.0MEN1, GHRH
46breast cancer10.0CDX2, GHRH, MEN1, SSTR5, LYVE1, CDKN2C
47serotonin syndrome10.0MEN1, GHRH, SSTR1
48pancreatic cancer10.0GHRH, SSTR2, MEN1, CDX2
49maturity-onset diabetes of the young10.0PDX1, NEUROD1
50neuroendocrine carcinoma10.0ASCL1, MEN1, CDX2

Graphical network of the top 20 diseases related to Pancreatic Endocrine Tumors:



Diseases related to pancreatic endocrine tumors

Clinical Features for Pancreatic Endocrine Tumors

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Drugs & Therapeutics for Pancreatic Endocrine Tumors

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Pancreatic Endocrine Tumors

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Genetic Tests for Pancreatic Endocrine Tumors

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Anatomical Context for Pancreatic Endocrine Tumors

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32MalaCards
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MalaCards organs/tissues related to Pancreatic Endocrine Tumors:

32
Lung

Animal Models for Pancreatic Endocrine Tumors or affiliated genes

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36MGI
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Publications for Pancreatic Endocrine Tumors

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Genetic Variations for Pancreatic Endocrine Tumors

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Expression for genes affiliated with Pancreatic Endocrine Tumors

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Endocrine Tumors

Search GEO for disease gene expression data for Pancreatic Endocrine Tumors.

Pathways for genes affiliated with Pancreatic Endocrine Tumors

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53Reactome, 29KEGG, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Pancreatic Endocrine Tumors

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28IUPHAR, 44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Pancreatic Endocrine Tumors according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1[125i]cgp 239962810.9SSTR4, SSTR3, SSTR1, SSTR2, SSTR5
2srif-282810.9SSTR5, SSTR2, SSTR1, SSTR3, SSTR4
3srif-142810.9SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
4[125i]ltt-srif-282810.9SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
5[125i]tyr10-cst142810.9SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
6ke 1082810.9SSTR2, SSTR3, SSTR4, SSTR1, SSTR5
7lanreotide44 2811.9SSTR3, GHRH, SSTR5, SSTR2, SSTR1, SSTR4
8cst-172810.9SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
9cgp 239962810.8SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
10l-362,8552810.8SSTR4, SSTR3, SSTR2, SSTR1, SSTR5
11bim 230522810.8SSTR5, SSTR2, SSTR1, SSTR3, SSTR4
12[d-tyr8]cyn 1548062810.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
13bim 234542810.8SSTR5, SSTR1, SSTR4, SSTR3, SSTR2
14bim 236272810.8SSTR5, SSTR2, SSTR1, SSTR3, SSTR4
15[l-tyr8]cyn 1548062810.8SSTR3, SSTR5, SSTR2, SSTR1, SSTR4
16cyclosomatostatin5910.8SSTR1, SSTR5, SSTR2, SSTR4, SSTR3
17boc-ate2810.8SSTR3, SSTR2, SSTR5
18cst-142810.8SSTR4, SSTR2, SSTR5, SSTR1, SSTR3
19som-2302810.8SSTR5, SSTR2, SSTR1, SSTR3
20(1r,1s,3r/1r,1r,3s)-l-054,2645910.8SSTR2, SSTR5, SSTR1, SSTR3, SSTR4
21[111in,90y]dota-toc2810.8SSTR5, SSTR2, SSTR3
22cyn 1548065910.8SSTR5, SSTR3, SSTR2, SSTR1, SSTR4
23pasireotide44 1111.8SSTR5, SSTR2, SSTR1, SSTR3
24[111in,90y]dota-oc2810.8SSTR5, SSTR2, SSTR3
25somatostatin59 2411.8SSTR3, SSTR2, SSTR5, SSTR1, SSTR4
26des-aa5-[d-trp8]srif2810.8SSTR3, SSTR1, SSTR5, SSTR4
27bim 231972810.8SSTR5, SSTR2, SSTR3
28[111in,90y]dota-noc2810.8SSTR5, SSTR2, SSTR3
29bim 230562810.8SSTR3, SSTR2, SSTR5
30[111in,90y]dota-lan2810.8SSTR5, SSTR2, SSTR3
31noc-ate2810.8SSTR5, SSTR2, SSTR3
32octreotide44 59 28 1113.8GHRH, SSTR3, SSTR4, SSTR2, SSTR1, SSTR5
33l-363,3012810.8SSTR5, SSTR2, SSTR3
34prl-29152810.8SSTR5, SSTR4, SSTR3
35bim 230682810.7SSTR2, SSTR4, SSTR3
36[111in]dota-noc2810.7SSTR5, SSTR2, SSTR3
37nc 4-28b2810.7SSTR1, SSTR3, SSTR2
38bim 230232810.7SSTR5, SSTR2, SSTR3
39[111in]dota-boc-ate2810.7SSTR5, SSTR2, SSTR3
40[111in]dota-noc-ate2810.7SSTR3, SSTR5, SSTR2
41mk-6782810.7SSTR3, SSTR2, SSTR5
42bim 230502810.6SSTR5, SSTR1, SSTR3
43bim 230302810.6SSTR5, SSTR2, SSTR3
44111in-pentetreotide4410.6SSTR5, SSTR1, SSTR2
45vapreotide28 44 1112.6SSTR3, SSTR2, SSTR5
46bim 230342810.5SSTR2, SSTR3
47glucose4410.4SSTR1, PDX1, ISL1, LYVE1, SSTR2, GHRH
48thymidine44 2411.4PDX1, LYVE1, CDX2, SSTR2, SSTR5, MEN1
49ribonucleic acid4410.3SSTR2, SSTR5, GHRH, SSTR1, SSTR4
50[125i]tyr3 sms 201-9952810.2SSTR2, SSTR5

GO Terms for genes affiliated with Pancreatic Endocrine Tumors

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16Gene Ontology
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Cellular components related to Pancreatic Endocrine Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.4ISL1, MEN1, EGLN2, EGLN3, NEUROG3, NEUROD1
2cytoplasmGO:00573710.2CDKN2C, ISL1, MEN1, EGLN3, NEUROG3, NEUROD1
3integral to plasma membraneGO:00588710.1SSTR5, SSTR2, SSTR1, SSTR4, SSTR3, LYVE1

Biological processes related to Pancreatic Endocrine Tumors according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
2cellular response to glucocorticoid stimulusGO:07138510.8SSTR3, SSTR4, SSTR2, ISL1
3cellular response to estradiol stimulusGO:07139210.7SSTR2, SSTR1, SSTR3
4cerebellum developmentGO:02154910.7SSTR3, SSTR1, SSTR2, NEUROD1
5somatostatin signaling pathwayGO:03817010.7SSTR3, SSTR5
6forebrain developmentGO:03090010.7NEUROG3, SSTR2, SSTR1, SSTR4, SSTR3
7regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.7HIF1AN, EGLN3, EGLN2
8negative regulation of cell proliferationGO:00828510.7CDKN2C, PDX1, MEN1, SSTR5, SSTR2, SSTR1
9response to starvationGO:04259410.7SSTR2, SSTR1, SSTR3
10endocrine pancreas developmentGO:03101810.7NEUROD1, NEUROG3, PDX1
11peptidyl-proline hydroxylation to 4-hydroxy-L-prolineGO:01840110.7EGLN3, EGLN2
12forebrain neuron differentiationGO:02187910.7ASCL1, POU3F4
13positive regulation of neuron differentiationGO:04566610.7NEUROG3, NEUROD1, ASCL1
14glucose homeostasisGO:04259310.6SSTR5, NEUROD1, PDX1
15cell-cell signalingGO:00726710.6SSTR3, SSTR1, SSTR2, GHRH
16cellular response to hypoxiaGO:07145610.6EGLN2, EGLN3, HIF1AN
17neuron fate specificationGO:04866510.6ASCL1, ISL1
18nitric oxide mediated signal transductionGO:00726310.5NEUROD1, PDX1
19neurogenesisGO:02200810.5ASCL1, NEUROD1
20regulation of neuron apoptotic processGO:04352310.4EGLN3, EGLN2
21positive regulation of transcription from RNA polymerase II promoterGO:04594410.3PDX1, ISL1, MEN1, NEUROD1, ASCL1
22positive regulation of DNA bindingGO:04338810.1ISL1, PDX1

Molecular functions related to Pancreatic Endocrine Tumors according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1double-stranded DNA bindingGO:00369010.6MEN1, NEUROG3, NEUROD1, POU3F4, ASCL1
2somatostatin receptor activityGO:00499410.6SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
3oxygen sensor activityGO:01982610.6HIF1AN, EGLN2
4peptidyl-proline 4-dioxygenase activityGO:03154510.6EGLN3, EGLN2
5sequence-specific DNA binding transcription factor activityGO:00370010.5PDX1, ISL1, NEUROD1, POU3F4, CDX2, ASCL1
6RNA polymerase II transcription coactivator activityGO:00110510.5NEUROD1, ISL1
7chromatin bindingGO:00368210.4PDX1, ISL1, MEN1, NEUROD1
8bHLH transcription factor bindingGO:04342510.3ASCL1, ISL1
9L-ascorbic acid bindingGO:03141810.1EGLN3, EGLN2

Products for genes affiliated with Pancreatic Endocrine Tumors

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Sources for Pancreatic Endocrine Tumors

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet