MCID: PNC047
MIFTS: 45

Pancreatic Endocrine Tumors malady

Endocrine diseases, Cancer diseases categories
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Summaries for Pancreatic Endocrine Tumors

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Wikipedia:65 Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous... more...

MalaCards based summary: Pancreatic Endocrine Tumors is related to gastrinoma and acromegaly. An important gene associated with Pancreatic Endocrine Tumors is ST11 (suppression of tumorigenicity 11 (pancreas)), and among its related pathways are HIF1Alpha Pathway and Regulation of Hypoxia-inducible Factor (HIF) by Oxygen. The compounds bim 23059 and bim 23060 have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and pancreas, and related mouse phenotypes are craniofacial and endocrine/exocrine gland.

Aliases & Classifications for Pancreatic Endocrine Tumors

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Pancreatic Endocrine Tumors, Aliases & Descriptions:

Name: Pancreatic Endocrine Tumors 46 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Related Diseases for Pancreatic Endocrine Tumors

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Diseases related to Pancreatic Endocrine Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1gastrinoma30.3SSTR5, SSTR2, MEN1
2acromegaly30.3MEN1, SSTR5, SSTR2
3prolactinoma30.3MEN1, SSTR2, SSTR5
4insulinoma30.0MEN1, PAX4, SSTR5, SSTR2
5carcinoid syndrome29.9SSTR5, SSTR2, MEN1, ASCL1
6adenoma29.6CDKN2C, MEN1, SSTR2, SSTR5, ASCL1
7pancreatitis11.2
8non-functioning pancreatic endocrine tumor10.6
9multiple endocrine neoplasia10.6
10functioning pancreatic endocrine tumor10.5
11cystadenoma10.3
12neuroendocrine tumor10.3SSTR2
13wermer syndrome10.3MEN1
14microcystic adenoma10.3
15cushing's syndrome10.3
16zollinger-ellison syndrome10.3
17endotheliitis10.3
18diabetes mellitus10.1
19islet cell tumor10.1
20type 2 diabetes mellitus10.1
21duodenal ulcer10.1
22obstructive jaundice10.1
23tuberous sclerosis10.1
24hyperinsulinemic hypoglycemia10.1
25diabetes insipidus10.1
26hypoglycemia10.1
27neurofibromatosis10.1
28small cell carcinoma10.1
29duodenitis10.1
30merkel cell carcinoma10.1
31adenocarcinoma10.1
32thyroiditis10.1
33wdha syndrome10.1
34somatostatin analog10.1
35pancreatic cancer10.1SSTR2, MEN1
36glucagonoma10.1MEN1, SSTR5, SSTR2
37paraganglioma10.0MEN1, SSTR2
38pituitary tumors10.0SSTR5, SSTR2, MEN1
39pituitary adenoma10.0MEN1, SSTR5, SSTR2
40neuroendocrine carcinoma10.0ASCL1, MEN1
41parathyroid adenoma9.9MEN1, CDKN2C
42lung small cell carcinoma9.9MEN1, ASCL1, SSTR2
43thyroid medullary carcinoma9.8ASCL1, SSTR2, MEN1, SSTR5
44pheochromocytoma9.8MEN1, SSTR5, ASCL1, SSTR2
45meningioma9.7SSTR2, CDKN2C, SSTR5, MEN1

Graphical network of the top 20 diseases related to Pancreatic Endocrine Tumors:



Diseases related to pancreatic endocrine tumors

Symptoms for Pancreatic Endocrine Tumors

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Drugs & Therapeutics for Pancreatic Endocrine Tumors

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Drug clinical trials:

Search ClinicalTrials for Pancreatic Endocrine Tumors

Search NIH Clinical Center for Pancreatic Endocrine Tumors

Genetic Tests for Pancreatic Endocrine Tumors

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Anatomical Context for Pancreatic Endocrine Tumors

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MalaCards organs/tissues related to Pancreatic Endocrine Tumors:

32
Lung, Liver, Pancreas, Pancreatic islet, Endothelial, Spleen, Spinal cord, Thyroid, Ovary, Testes, Pituitary

Animal Models for Pancreatic Endocrine Tumors or affiliated genes

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MGI Mouse Phenotypes related to Pancreatic Endocrine Tumors:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.4POU3F4, ASCL1, MEN1, EGLN2
2MP:00053797.9CDKN2C, MEN1, SSTR5, ASCL1, PAX4
3MP:00053857.9CDKN2C, EGLN2, HIF1AN, SSTR2, MEN1
4MP:00053767.6SSTR5, EGLN2, CDKN2C, MEN1, SSTR2, HIF1AN
5MP:00053847.6ASCL1, MEN1, CDKN2C, EGLN2, HIF1AN
6MP:00053867.5POU3F4, ASCL1, SSTR2, CDKN2C, HIF1AN
7MP:00053787.3MEN1, SSTR5, ASCL1, PAX4, HIF1AN, CDKN2C

Publications for Pancreatic Endocrine Tumors

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Articles related to Pancreatic Endocrine Tumors:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
Non-functioning pancreatic endocrine tumors: eleven-year experience in a single institute. (24965405)
2014
2
Cytologic features of lipid-rich variant of pancreatic endocrine tumor-Report of two cases with literature review. (23749767)
2013
3
IMP3, NESP55, TTF-1 and CDX2 serve as an immunohistochemical panel in the distinction among small-cell carcinoma, gastrointestinal carcinoid, and pancreatic endocrine tumor metastasized to the liver. (22495359)
2012
4
Current surgical management of pancreatic endocrine tumor liver metastases. (21669565)
2011
5
Curative resection of a huge malignant pancreatic endocrine tumor by pancreatoduodenectomy with portal and superior mesenteric vein resection and reconstruction using the right ovarian vein: report of a case. (21874427)
2011
6
Pax8 detection in well-differentiated pancreatic endocrine tumors: how reliable is it? (22067332)
2011
7
Pancreatic endocrine tumors with major vascular abutment, involvement, or encasement and indication for resection. (21690450)
2011
8
Profiling of somatostatin receptor subtype expression by quantitative PCR and correlation with clinicopathological features in pancreatic endocrine tumors. (20717067)
2010
9
KIT is an independent prognostic marker for pancreatic endocrine tumors: a finding derived from analysis of islet cell differentiation markers. (19574886)
2009
10
Pancreatic endocrine tumor in multiple endocrine neoplasia type 1 syndrome with intraductal growth into the main pancreatic duct. (19307930)
2009
11
Immunohistochemical and clinicopathological correlation of the metastasis-associated gene 1 (MTA1) expression in benign and malignant pancreatic endocrine tumors. (19377441)
2009
12
Heterogeneity of tumor prognostic markers: a reproducibility study applied to liver metastases of pancreatic endocrine tumors. (18997736)
2009
13
Proliferative rate in endoscopic ultrasound fine-needle aspiration of pancreatic endocrine tumors: correlation with clinical behavior. (19347828)
2009
14
VHL inactivation is an important pathway for the development of malignant sporadic pancreatic endocrine tumors. (19690016)
2009
15
Treatment of a pancreatic endocrine tumor by ethanol injection guided by endoscopic ultrasound. (19090457)
2008
16
Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors. (18927305)
2008
17
Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies. (18798544)
2008
18
Re: Treatment of a pancreatic endocrine tumor by ethanol injection (PEI) guided by endoscopic ultrasound. (19009494)
2008
19
Treatment of a pancreatic endocrine tumor by ethanol injection (PEI) guided by endoscopic ultrasound. (18633893)
2008
20
Pancreatic endocrine tumors-c-erb B2 (Her-2/neu), bcl-2, and p-53 immunohistochemical testing and their value in assessing prognosis. (18091321)
2008
21
Prognostic factors and survival in 324 patients with pancreatic endocrine tumor treated at a single institution. (19047107)
2008
22
Islet 1 (Isl1) expression is a reliable marker for pancreatic endocrine tumors and their metastases. (18300808)
2008
23
Mutational analysis of p27 (CDKN1B) and p18 (CDKN2C) in sporadic pancreatic endocrine tumors argues against tumor-suppressor function. (17710155)
2007
24
Management of nonfunctioning pancreatic endocrine tumors in the context of multiple endocrine neoplasia type 1 syndrome. (17925918)
2007
25
Lymphatic vessel endothelial hyaluronan receptor 1 immunocytochemical staining for pancreatic islets and pancreatic endocrine tumors. (18090227)
2007
26
Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. (17443844)
2007
27
Clinicopathologic and immunohistochemical correlation in sporadic pancreatic endocrine tumors: possible roles of utrophin and cyclin D1 in malignant progression. (17306326)
2007
28
Management of pancreatic endocrine tumors in multiple endocrine neoplasia type 1. (16680581)
2006
29
Pancreatic endocrine tumor with partial acinar cell differentiation. (17004975)
2006
30
Spindle cell pancreatic endocrine tumor associated with Cushing's syndrome. (16199900)
2005
31
Current advances in the diagnosis and treatment of pancreatic endocrine tumors. (15608508)
2005
32
Ectopic bioactive luteinizing hormone secretion by a pancreatic endocrine tumor, manifested as luteinized granulosa-thecal cell tumor of the ovaries. (15687346)
2005
33
Utility of combined use of plasma levels of chromogranin A and pancreatic polypeptide in the diagnosis of gastrointestinal and pancreatic endocrine tumors. (15053236)
2004
34
Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumors. (15501970)
2004
35
Frequent methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene in pancreatic endocrine tumors. (12629131)
2003
36
CpG island methylation in carcinoid and pancreatic endocrine tumors. (12584572)
2003
37
Immunohistochemical analysis of cyclooxygenase (COX)-2 expression in pancreatic endocrine tumors: association with tumor progression and proliferation. (11881729)
2001
38
Immunohistochemical expression of transforming growth factor alpha and epidermal growth factor receptor in pancreatic endocrine tumors. (11727256)
2001
39
Pancreatic endocrine tumors: recent advances. (10436815)
1999
40
Cellular composition and anatomic distribution in nonfunctioning pancreatic endocrine tumors: immunohistochemical study of 30 cases. (10374408)
1998
41
Lack of p53 immunoreactivity in pancreatic endocrine tumors. (8743819)
1996
42
A pancreatic endocrine tumor arising within a serous cystadenoma of the pancreas. (8604814)
1996
43
Immunolocalization of neuropeptide Y in human pancreatic endocrine tumors. (7479336)
1995
44
Multihormonal pancreatic endocrine tumor in a European lynx (Lynx lynx). (7725607)
1995
45
Glucagon-like peptide 1 immunoreactivity in gastroentero-pancreatic endocrine tumors: a light- and electron-microscopic study. (8062345)
1994
46
Islet amyloid polypeptide and calcitonin gene-related peptide immunoreactivity in amyloid and tumor cells of canine pancreatic endocrine tumors. (1972303)
1990
47
Factors that determine cell-specific gene expression in pancreatic endocrine tumor cells. (2559019)
1989
48
Multihormonal pancreatic endocrine tumor in a dog with duodenal ulcers and hypertrophic gastropathy. (2839924)
1988
49
Skeletal metastasis from gastrinoma. An uncommon manifestation of pancreatic endocrine tumor. (3791791)
1986
50
Pancreatic endocrine tumor presenting with obstructive jaundice. (6318554)
1984

Variations for Pancreatic Endocrine Tumors

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Expression for genes affiliated with Pancreatic Endocrine Tumors

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Expression patterns in normal tissues for genes affiliated with Pancreatic Endocrine Tumors

Search GEO for disease gene expression data for Pancreatic Endocrine Tumors.

Pathways for genes affiliated with Pancreatic Endocrine Tumors

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Compounds for genes affiliated with Pancreatic Endocrine Tumors

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 61Tocris Bioscience, 24HMDB
See all sources

Compounds related to Pancreatic Endocrine Tumors according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1bim 230592810.3SSTR5, SSTR2
2bim 230602810.3SSTR2, SSTR5
3[125i]tyr3 sms 201-9952810.2SSTR2, SSTR5
4mk-6782810.2SSTR5, SSTR2
5bim 230302810.2SSTR5, SSTR2
6[111in,90y]dota-noc2810.2SSTR2, SSTR5
7bim 231972810.2SSTR5, SSTR2
8[111in,90y]dota-oc2810.2SSTR2, SSTR5
9boc-ate2810.2SSTR2, SSTR5
10[111in]dota-boc-ate2810.2SSTR2, SSTR5
11bim 230232810.2SSTR2, SSTR5
12[111in]dota-noc2810.2SSTR2, SSTR5
13[111in]dota-noc-ate2810.2SSTR2, SSTR5
14noc-ate2810.2SSTR5, SSTR2
15[111in,90y]dota-lan2810.2SSTR5, SSTR2
16[111in,90y]dota-toc2810.2SSTR2, SSTR5
17l-363,3012810.2SSTR5, SSTR2
18bim 230562810.2SSTR5, SSTR2
19som-2302810.2SSTR2, SSTR5
20pasireotide44 1111.2SSTR5, SSTR2
21[d-tyr8]cyn 1548062810.2SSTR5, SSTR2
22[l-tyr8]cyn 1548062810.2SSTR5, SSTR2
23[125i]cgp 239962810.2SSTR2, SSTR5
24bim 236272810.2SSTR2, SSTR5
25bim 234542810.2SSTR2, SSTR5
26l-362,8552810.2SSTR5, SSTR2
27srif-282810.1SSTR5, SSTR2
28srif-142810.1SSTR5, SSTR2
29[125i]tyr10-cst142810.1SSTR5, SSTR2
30[125i]ltt-srif-282810.1SSTR5, SSTR2
31cst-172810.1SSTR2, SSTR5
32cgp 239962810.1SSTR5, SSTR2
33ke 1082810.1SSTR5, SSTR2
34bim 230522810.1SSTR5, SSTR2
35cyn 1548066110.1SSTR5, SSTR2
36(1r,1s,3r/1r,1r,3s)-l-054,2646110.0SSTR2, SSTR5
37cyclosomatostatin6110.0SSTR2, SSTR5
38cst-142810.0SSTR5, SSTR2
39vapreotide44 28 1112.0SSTR5, SSTR2
40111in-pentetreotide4410.0SSTR5, SSTR2
41somatostatin61 2410.9SSTR2, SSTR5
42lanreotide44 2810.9SSTR2, SSTR5
43octreotide44 61 28 1112.7SSTR5, SSTR2
44alpha-ketoglutarate449.5HIF1AN, EGLN2
45thymidine44 2410.3SSTR5, SSTR2, MEN1
46dopamine44 28 24 1111.9SSTR2, SSTR5, ASCL1

GO Terms for genes affiliated with Pancreatic Endocrine Tumors

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Biological processes related to Pancreatic Endocrine Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to hypoxiaGO:0714569.5EGLN2, HIF1AN
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.5SSTR2, SSTR5
3forebrain neuron differentiationGO:0218799.5ASCL1, POU3F4
4regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.4HIF1AN, EGLN2
5negative regulation of cell proliferationGO:0082858.5CDKN2C, MEN1, SSTR2, SSTR5

Molecular functions related to Pancreatic Endocrine Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatostatin receptor activityGO:0049949.5SSTR5, SSTR2
2oxygen sensor activityGO:0198269.4HIF1AN, EGLN2
3sequence-specific DNA bindingGO:0435658.9MEN1, ASCL1, PAX4
4double-stranded DNA bindingGO:0036908.5MEN1, ASCL1, PAX4, POU3F4

Products for genes affiliated with Pancreatic Endocrine Tumors

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  • Antibodies
  • Proteins
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Sources for Pancreatic Endocrine Tumors

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet