MCID: PNC047
MIFTS: 48

Pancreatic Endocrine Tumors malady

Gastrointestinal, Endocrine, Cancer categories

Summaries for Pancreatic Endocrine Tumors

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous... more...

MalaCards: Pancreatic Endocrine Tumors, also known as pancreatic endocrine tumor, is related to multiple endocrine neoplasia and zollinger-ellison syndrome. An important gene associated with Pancreatic Endocrine Tumors is ST11 (suppression of tumorigenicity 11 (pancreas)), and among its related pathways are Regulation of beta-cell development and Transcription factors in neurogenesis. The compounds ke 108 and l-362,855 have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and lung, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Pancreatic Endocrine Tumors

Sources:
47OMIM, 49Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal, Endocrine


Aliases & Descriptions:

pancreatic endocrine tumors 47
pancreatic endocrine tumor 49


External Ids:

ICD10 via Orphanet26 E16.8

Related Diseases for Pancreatic Endocrine Tumors

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pancreatic Endocrine Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1multiple endocrine neoplasia30.8MEN1
2zollinger-ellison syndrome30.5GHRH, MEN1
3adenoma30.4ASCL1, GHRH, SSTR5, SSTR2, SSTR1, MEN1
4cushing's syndrome30.4GHRH
5gastrinoma30.2MEN1, SSTR5, SSTR1, SSTR2
6acromegaly30.2SSTR1, SSTR5, MEN1, SSTR2, GHRH
7insulinoma30.2SSTR5, SSTR1, GHRH, SSTR4, MEN1, PDX1
8prolactinoma30.2SSTR3, SSTR5, MEN1, SSTR2, SSTR4, SSTR1
9carcinoid syndrome30.2ASCL1, GHRH, SSTR3, MEN1, SSTR1, SSTR2
10adenocarcinoma30.2MEN1, NEUROD1, CDX2, SSTR1, SSTR2, PDX1
11anal endocrine tumor10.6
12n syndrome10.5
13cystadenoma10.4
14pancreatic endocrine carcinoma10.4
15pancreatic serous cystadenoma10.4
16functioning pancreatic endocrine tumor10.4
17microcystic adenoma10.3
18pancreatic islet cell tumors10.3
19pancreatic adenoma10.3
20somatostatin analog10.3
21neurofibromatosis10.1
22duodenal ulcer10.1
23obstructive jaundice10.1
24tuberous sclerosis10.1
25pancreatic vasoactive intestinal peptide producing tumor10.1
26small cell carcinoma10.1
27diabetes insipidus10.1
28amyloid tumor10.1
29pancreatic gastrinoma10.1
30hypoglycemia10.1
31hyperinsulinemic hypoglycemia10.1
32merkel cell carcinoma10.1
33wdha syndrome10.1
34gastric endocrine tumor10.1
35duodenal endocrine tumor10.1
36pheochromocytoma10.0SSTR4, SSTR1, SSTR2, SSTR5, CDX2, ASCL1
37pituitary adenoma10.0GHRH, NEUROD1, SSTR2, SSTR1, SSTR3, MEN1
38pituitary tumors10.0MEN1, GHRH, SSTR5, SSTR2, SSTR1, SSTR4
39prostate cancer10.0SSTR4, SSTR1, GHRH, CDX2, SSTR5, CDKN2C
40thyroid medullary carcinoma10.0SSTR5, MEN1, ASCL1, SSTR1, SSTR2
41glucagonoma10.0SSTR2, MEN1, GHRH, SSTR5, PDX1
42hepatocellular carcinoma10.0MEN1, SSTR2, CDX2, CDKN2C
43somatostatinoma10.0GHRH, SSTR2
44vipoma10.0MEN1, GHRH
45neuroendocrine tumor10.0MEN1, SSTR2, CDX2, ASCL1
46breast cancer10.0CDX2, GHRH, MEN1, SSTR5, LYVE1, CDKN2C
47serotonin syndrome10.0MEN1, GHRH, SSTR1
48pancreatic cancer10.0GHRH, SSTR2, MEN1, CDX2
49maturity-onset diabetes of the young10.0PDX1, NEUROD1
50neuroendocrine carcinoma10.0ASCL1, MEN1, CDX2

Graphical network of the top 20 diseases related to Pancreatic Endocrine Tumors:



Diseases related to pancreatic endocrine tumors

Clinical Features for Pancreatic Endocrine Tumors

Drugs & Therapeutics for Pancreatic Endocrine Tumors

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Pancreatic Endocrine Tumors

Drug clinical trials:

Search ClinicalTrials for Pancreatic Endocrine Tumors

Search NIH Clinical Center for Pancreatic Endocrine Tumors

Search CenterWatch for Pancreatic Endocrine Tumors

Genetic Tests for Pancreatic Endocrine Tumors

Anatomical Context for Pancreatic Endocrine Tumors

Sources:
33MalaCards
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MalaCards organs/tissues related to Pancreatic Endocrine Tumors:

33
Small intestine, Liver, Lung, Pancreas, Thyroid, T cells, B cells, Endothelial, Pancreatic islet

Animal Models for Pancreatic Endocrine Tumors or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Pancreatic Endocrine Tumors

Sources:
51PubMed
See all sources

Articles related to Pancreatic Endocrine Tumors:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Penetrance of functioning and nonfunctioning pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1 in the second decade of life. (24178797)
2014
2
The current strategy for managing pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1. (22844555)
2012
3
Surgical treatment of pancreatic endocrine tumors in multiple endocrine neoplasia type 1. (22584720)
2012
4
Multiple endocrine neoplasia and different multiple pancreatic neuroendocrine tumors: is there any relation? (22940827)
2012
5
Presentation and outcome of pancreaticoduodenal endocrine tumors in multiple endocrine neoplasia type 1 syndrome. (21464564)
2011
6
Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. (19917848)
2010
7
MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases. (20566584)
2010
8
Cleaved caspase-3 immunocytochemical staining for pancreatic islets and pancreatic endocrine tumors: A potential marker for biological malignancy. (21099299)
2010
9
KIT is an independent prognostic marker for pancreatic endocrine tumors: a finding derived from analysis of islet cell differentiation markers. (19574886)
2009
10
Immunohistochemical and clinicopathological correlation of the metastasis-associated gene 1 (MTA1) expression in benign and malignant pancreatic endocrine tumors. (19377441)
2009
11
Heterogeneity of tumor prognostic markers: a reproducibility study applied to liver metastases of pancreatic endocrine tumors. (18997736)
2009
12
CEACAM1 expression in pancreatic endocrine tumors. (19349857)
2009
13
Asymptomatic children with multiple endocrine neoplasia type 1 mutations may harbor nonfunctioning pancreatic neuroendocrine tumors. (19622622)
2009
14
Diagnosis and treatment of pancreatic endocrine tumors]. (19838018)
2009
15
Islet 1 (Isl1) expression is a reliable marker for pancreatic endocrine tumors and their metastases. (18300808)
2008
16
Endocrine pancreatic tumors in von Hippel-Lindau disease: clinical, histological, and genetic features. (18580449)
2008
17
Clinicopathologic and immunohistochemical correlation in sporadic pancreatic endocrine tumors: possible roles of utrophin and cyclin D1 in malignant progression. (17306326)
2007
18
WHO 2004 criteria and CK19 are reliable prognostic markers in pancreatic endocrine tumors. (18059224)
2007
19
Endocrine pancreatic tumors with glucagon hypersecretion: a retrospective study of 23 cases during 20 years. (17873310)
2007
20
Pancreatic endocrine tumors are a rare manifestation of the neurofibromatosis type 1 phenotype: molecular analysis of a malignant insulinoma in a NF-1 patient. (16861979)
2006
21
Identification of potential therapeutic targets by gene-expression profiling in pancreatic endocrine tumors. (17064702)
2006
22
Small neuroendocrine pancreatic tumors in multiple endocrine neoplasia type 1 (MEN1): least significant change of tumor diameter as determined by endoscopic ultrasound (EUS) imaging. (16915538)
2006
23
Prospective endoscopic ultrasonographic evaluation of the frequency of nonfunctioning pancreaticoduodenal endocrine tumors in patients with multiple endocrine neoplasia type 1. (16454829)
2006
24
Composite glandular and endocrine tumors of the stomach with pancreatic acinar differentiation. (16224221)
2005
25
Utility of combined use of plasma levels of chromogranin A and pancreatic polypeptide in the diagnosis of gastrointestinal and pancreatic endocrine tumors. (15053236)
2004
26
Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumors. (15501970)
2004
27
Expression of lymphangiogenic factors and evidence of intratumoral lymphangiogenesis in pancreatic endocrine tumors. (15466385)
2004
28
Histidine decarboxylase expression in pancreatic endocrine cells and related tumors. (15144399)
2004
29
Frequent methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene in pancreatic endocrine tumors. (12629131)
2003
30
CpG island methylation in carcinoid and pancreatic endocrine tumors. (12584572)
2003
31
DPC4/Smad4: no mutations, rare allelic imbalances, and retained protein expression in pancreatic endocrine tumors. (14639103)
2003
32
Treatment of malignant endocrine pancreatic tumors with a combination of alpha-interferon and somatostatin analogs. (12025889)
2002
33
Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. (11889202)
2002
34
Immunohistochemical analysis of cyclooxygenase (COX)-2 expression in pancreatic endocrine tumors: association with tumor progression and proliferation. (11881729)
2001
35
Anomalous overexpression of p27(Kip1) in sporadic pancreatic endocrine tumors. (11266285)
2001
36
Immunohistochemical expression of chromogranins A and B, prohormone convertases 2 and 3, and amidating enzyme in carcinoid tumors and pancreatic endocrine tumors. (10697270)
2000
37
Pancreaticoduodenal endocrine tumors in multiple endocrine neoplasia type 1: surgery or surveillance? (11114630)
2000
38
Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms. (10027401)
1999
39
Genetic alterations on 3p, 11q13, and 18q in nonfamilial and MEN 1-associated pancreatic endocrine tumors. (10502325)
1999
40
Cellular composition and anatomic distribution in nonfunctioning pancreatic endocrine tumors: immunohistochemical study of 30 cases. (10374408)
1998
41
Mutation of the MENIN gene in sporadic pancreatic endocrine tumors. (9766672)
1998
42
Pancreatic polypeptide is a useful plasma marker for radiographically evident pancreatic islet cell tumors in patients with multiple endocrine neoplasia type 1. (9426414)
1997
43
Lack of p53 immunoreactivity in pancreatic endocrine tumors. (8743819)
1996
44
Immunohistochemical study of 100 pancreatic tumors in 28 patients with multiple endocrine neoplasia, type I. (8898842)
1996
45
Immunolocalization of neuropeptide Y in human pancreatic endocrine tumors. (7479336)
1995
46
111In-octreotide scintigraphy: a tool to select patients with endocrine pancreatic tumors for octreotide treatment? (8534589)
1995
47
Glucagon-like peptide-1 (GLP-1) molecular forms in human pancreatic endocrine tumors resemble those in intestine rather than pancreas. (7835211)
1994
48
Different splice variants of CD44 are expressed in gastrinomas but not in other subtypes of endocrine pancreatic tumors. (7508823)
1994
49
Endocrine syndromes associated with pancreatic islet cell tumors. (4298136)
1968
50
Clinics on endocrine and metabolic diseases. 3. Hyperinsulinism: review of 95 cases of functioning pancreatic islet cell tumors. (13748469)
1960

Genetic Variations for Pancreatic Endocrine Tumors

Expression for genes affiliated with Pancreatic Endocrine Tumors

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pancreatic Endocrine Tumors

Search GEO for disease gene expression data for Pancreatic Endocrine Tumors.

Pathways for genes affiliated with Pancreatic Endocrine Tumors

Sources:
54Reactome, 30KEGG, 12EMD Millipore, 52QIAGEN, 38NCBI BioSystems Database, 50PharmGKB
See all sources

Compounds for genes affiliated with Pancreatic Endocrine Tumors

Sources:
29IUPHAR, 45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB
See all sources

Compounds related to Pancreatic Endocrine Tumors according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1ke 1082910.9SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
2l-362,8552910.9SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
3bim 236272910.9SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
4cgp 239962910.9SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
5[d-tyr8]cyn 1548062910.9SSTR2, SSTR1, SSTR4, SSTR3, SSTR5
6[l-tyr8]cyn 1548062910.9SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
7lanreotide45 2911.9SSTR3, SSTR4, SSTR1, SSTR2, SSTR5, GHRH
8bim 234542910.9SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
9[125i]ltt-srif-282910.8SSTR3, SSTR5, SSTR2, SSTR1, SSTR4
10srif-282910.8SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
11srif-142910.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
12[125i]tyr10-cst142910.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
13bim 230522910.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
14[125i]cgp 239962910.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
15cst-172910.8SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
16(1r,1s,3r/1r,1r,3s)-l-054,2646010.8SSTR4, SSTR1, SSTR2, SSTR5, SSTR3
17bim 230562910.8SSTR5, SSTR2, SSTR3
18cst-142910.8SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
19som-2302910.8SSTR5, SSTR2, SSTR1, SSTR3
20cyclosomatostatin6010.8SSTR5, SSTR3, SSTR4, SSTR1, SSTR2
21boc-ate2910.8SSTR5, SSTR2, SSTR3
22cyn 1548066010.8SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
23pasireotide45 1111.8SSTR5, SSTR2, SSTR1, SSTR3
24[111in,90y]dota-oc2910.8SSTR5, SSTR2, SSTR3
25somatostatin60 2411.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
26des-aa5-[d-trp8]srif2910.8SSTR5, SSTR1, SSTR4, SSTR3
27bim 231972910.8SSTR5, SSTR2, SSTR3
28[111in,90y]dota-noc2910.8SSTR5, SSTR2, SSTR3
29l-363,3012910.8SSTR3, SSTR2, SSTR5
30[111in,90y]dota-toc2910.8SSTR2, SSTR3, SSTR5
31[111in,90y]dota-lan2910.8SSTR5, SSTR2, SSTR3
32octreotide45 60 29 1113.8GHRH, SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
33noc-ate2910.8SSTR5, SSTR2, SSTR3
34[111in]dota-noc2910.8SSTR5, SSTR2, SSTR3
35prl-29152910.7SSTR5, SSTR4, SSTR3
36bim 230232910.7SSTR5, SSTR2, SSTR3
37[111in]dota-boc-ate2910.7SSTR5, SSTR2, SSTR3
38bim 230682910.7SSTR2, SSTR4, SSTR3
39nc 4-28b2910.7SSTR3, SSTR1, SSTR2
40bim 230502910.7SSTR5, SSTR1, SSTR3
41bim 230302910.7SSTR5, SSTR2, SSTR3
42mk-6782910.7SSTR5, SSTR2, SSTR3
43[111in]dota-noc-ate2910.6SSTR5, SSTR2, SSTR3
44vapreotide29 45 1112.6SSTR5, SSTR2, SSTR3
45111in-pentetreotide4510.6SSTR5, SSTR2, SSTR1
46[125i]tyr11-srif-142910.5SSTR4, SSTR5
47glucose4510.4PDX1, ISL1, NEUROG3, NEUROD1, GHRH, SSTR2
48thymidine45 2411.4PDX1, MEN1, SSTR5, SSTR2, CDX2, LYVE1
49ribonucleic acid4510.3GHRH, SSTR5, SSTR2, SSTR1, SSTR4
50nc 8-122910.2SSTR3, SSTR2

GO Terms for genes affiliated with Pancreatic Endocrine Tumors

Sources:
16Gene Ontology
See all sources

Cellular components related to Pancreatic Endocrine Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.4ISL1, MEN1, EGLN2, EGLN3, NEUROG3, NEUROD1
2cytoplasmGO:00573710.2CDKN2C, ISL1, MEN1, EGLN3, NEUROG3, NEUROD1
3integral to plasma membraneGO:00588710.1SSTR5, SSTR2, SSTR1, SSTR4, SSTR3, LYVE1

Biological processes related to Pancreatic Endocrine Tumors according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
2cellular response to glucocorticoid stimulusGO:07138510.8SSTR3, SSTR4, SSTR2, ISL1
3cellular response to estradiol stimulusGO:07139210.7SSTR2, SSTR1, SSTR3
4cerebellum developmentGO:02154910.7SSTR3, SSTR1, SSTR2, NEUROD1
5somatostatin signaling pathwayGO:03817010.7SSTR3, SSTR5
6forebrain developmentGO:03090010.7NEUROG3, SSTR2, SSTR1, SSTR4, SSTR3
7regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.7HIF1AN, EGLN3, EGLN2
8negative regulation of cell proliferationGO:00828510.7CDKN2C, PDX1, MEN1, SSTR5, SSTR2, SSTR1
9response to starvationGO:04259410.7SSTR2, SSTR1, SSTR3
10endocrine pancreas developmentGO:03101810.7NEUROD1, NEUROG3, PDX1
11peptidyl-proline hydroxylation to 4-hydroxy-L-prolineGO:01840110.7EGLN3, EGLN2
12forebrain neuron differentiationGO:02187910.7ASCL1, POU3F4
13positive regulation of neuron differentiationGO:04566610.7NEUROG3, NEUROD1, ASCL1
14glucose homeostasisGO:04259310.6SSTR5, NEUROD1, PDX1
15cell-cell signalingGO:00726710.6SSTR3, SSTR1, SSTR2, GHRH
16cellular response to hypoxiaGO:07145610.6EGLN2, EGLN3, HIF1AN
17neuron fate specificationGO:04866510.6ASCL1, ISL1
18nitric oxide mediated signal transductionGO:00726310.5NEUROD1, PDX1
19neurogenesisGO:02200810.5ASCL1, NEUROD1
20regulation of neuron apoptotic processGO:04352310.4EGLN3, EGLN2
21positive regulation of transcription from RNA polymerase II promoterGO:04594410.3PDX1, ISL1, MEN1, NEUROD1, ASCL1
22positive regulation of DNA bindingGO:04338810.1ISL1, PDX1

Molecular functions related to Pancreatic Endocrine Tumors according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1double-stranded DNA bindingGO:00369010.6MEN1, NEUROG3, NEUROD1, POU3F4, ASCL1
2somatostatin receptor activityGO:00499410.6SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
3oxygen sensor activityGO:01982610.6HIF1AN, EGLN2
4peptidyl-proline 4-dioxygenase activityGO:03154510.6EGLN3, EGLN2
5sequence-specific DNA binding transcription factor activityGO:00370010.5PDX1, ISL1, NEUROD1, POU3F4, CDX2, ASCL1
6RNA polymerase II transcription coactivator activityGO:00110510.5NEUROD1, ISL1
7chromatin bindingGO:00368210.4PDX1, ISL1, MEN1, NEUROD1
8bHLH transcription factor bindingGO:04342510.3ASCL1, ISL1
9L-ascorbic acid bindingGO:03141810.1EGLN3, EGLN2

Products for genes affiliated with Pancreatic Endocrine Tumors

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Sources for Pancreatic Endocrine Tumors

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet