MCID: PNC047
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Pancreatic Endocrine Tumors malady

Gastrointestinal diseases, Endocrine diseases, Cancer diseases, Rare diseases categories
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Summaries for Pancreatic Endocrine Tumors

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65Wikipedia, 33MalaCards
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Wikipedia:65 Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous... more...

MalaCards: Pancreatic Endocrine Tumors, also known as pancreatic endocrine tumor, is related to adenoma and gastrinoma. An important gene associated with Pancreatic Endocrine Tumors is ST11 (suppression of tumorigenicity 11 (pancreas)), and among its related pathways are HIF1Alpha Pathway and Regulation of Hypoxia-inducible Factor (HIF) by Oxygen. The compounds bim 23059 and bim 23060 have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and pancreas, and related mouse phenotypes are craniofacial and endocrine/exocrine gland.

Aliases & Classifications for Pancreatic Endocrine Tumors

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47OMIM, 49Orphanet, 26ICD10 via Orphanet
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Related Diseases for Pancreatic Endocrine Tumors

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17GeneCards, 18GeneDecks
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Diseases related to Pancreatic Endocrine Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.2CDKN2C, MEN1, SSTR2, SSTR5, ASCL1
2gastrinoma30.2SSTR5, SSTR2, MEN1
3acromegaly30.2MEN1, SSTR2, SSTR5
4prolactinoma30.2SSTR5, SSTR2, MEN1
5insulinoma30.1PAX4, SSTR5, SSTR2, MEN1
6carcinoid syndrome30.1ASCL1, SSTR5, SSTR2, MEN1
7pancreatitis11.1
8multiple endocrine neoplasia10.5
9non-functioning pancreatic endocrine tumor10.5
10functioning pancreatic endocrine tumor10.4
11cystadenoma10.3
12microcystic adenoma10.2
13cushing's syndrome10.2
14zollinger-ellison syndrome10.2
15neurofibromatosis10.1
16pancreatic endocrine carcinoma10.1
17duodenal ulcer10.1
18diabetes insipidus10.1
19hypoglycemia10.1
20duodenitis10.1
21obstructive jaundice10.1
22tuberous sclerosis10.1
23small cell carcinoma10.1
24merkel cell carcinoma10.1
25hyperinsulinemic hypoglycemia10.1
26adenocarcinoma10.1
27diabetes mellitus10.1
28thyroiditis10.1
29type 2 diabetes mellitus10.1
30wdha syndrome10.1
31somatostatin analog10.1
32endotheliitis10.1
33neuroendocrine tumor10.1SSTR2
34wermer syndrome10.1MEN1
35pancreatic cancer10.0MEN1, SSTR2
36glucagonoma10.0MEN1, SSTR2, SSTR5
37paraganglioma10.0SSTR2, MEN1
38pituitary tumors10.0SSTR5, SSTR2, MEN1
39pituitary adenoma10.0MEN1, SSTR2, SSTR5
40neuroendocrine carcinoma10.0MEN1, ASCL1
41parathyroid adenoma10.0MEN1, CDKN2C
42lung small cell carcinoma10.0MEN1, SSTR2, ASCL1
43thyroid medullary carcinoma10.0MEN1, SSTR2, SSTR5, ASCL1
44pheochromocytoma10.0ASCL1, SSTR5, SSTR2, MEN1
45meningioma9.9SSTR5, SSTR2, MEN1, CDKN2C

Graphical network of the top 20 diseases related to Pancreatic Endocrine Tumors:



Diseases related to pancreatic endocrine tumors

Symptoms for Pancreatic Endocrine Tumors

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Drugs & Therapeutics for Pancreatic Endocrine Tumors

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pancreatic Endocrine Tumors

Search NIH Clinical Center for Pancreatic Endocrine Tumors

Genetic Tests for Pancreatic Endocrine Tumors

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Anatomical Context for Pancreatic Endocrine Tumors

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33MalaCards
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MalaCards organs/tissues related to Pancreatic Endocrine Tumors:

33
Lung, Liver, Pancreas, Pancreatic islet, Spleen, Endothelial, Testes, Ovary, Thyroid, Spinal cord, Pituitary

Animal Models for Pancreatic Endocrine Tumors or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pancreatic Endocrine Tumors:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.4POU3F4, ASCL1, MEN1, EGLN2
2MP:00053797.9CDKN2C, MEN1, SSTR5, ASCL1, PAX4
3MP:00053857.9CDKN2C, EGLN2, HIF1AN, SSTR2, MEN1
4MP:00053767.6SSTR5, EGLN2, CDKN2C, MEN1, SSTR2, HIF1AN
5MP:00053847.6ASCL1, MEN1, CDKN2C, EGLN2, HIF1AN
6MP:00053867.5POU3F4, ASCL1, SSTR2, CDKN2C, HIF1AN
7MP:00053787.3MEN1, SSTR5, ASCL1, PAX4, HIF1AN, CDKN2C

Publications for Pancreatic Endocrine Tumors

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52PubMed
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Articles related to Pancreatic Endocrine Tumors:

(show top 50)    (show all 110)
idTitleAuthorsYear
1
Cytologic features of lipid-rich variant of pancreatic endocrine tumor-Report of two cases with literature review. (23749767)
2013
2
IMP3, NESP55, TTF-1 and CDX2 serve as an immunohistochemical panel in the distinction among small-cell carcinoma, gastrointestinal carcinoid, and pancreatic endocrine tumor metastasized to the liver. (22495359)
2012
3
Current surgical management of pancreatic endocrine tumor liver metastases. (21669565)
2011
4
Curative resection of a huge malignant pancreatic endocrine tumor by pancreatoduodenectomy with portal and superior mesenteric vein resection and reconstruction using the right ovarian vein: report of a case. (21874427)
2011
5
Profiling of somatostatin receptor subtype expression by quantitative PCR and correlation with clinicopathological features in pancreatic endocrine tumors. (20717067)
2010
6
Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. (19917848)
2010
7
KIT is an independent prognostic marker for pancreatic endocrine tumors: a finding derived from analysis of islet cell differentiation markers. (19574886)
2009
8
Pancreatic endocrine tumor in multiple endocrine neoplasia type 1 syndrome with intraductal growth into the main pancreatic duct. (19307930)
2009
9
Immunohistochemical and clinicopathological correlation of the metastasis-associated gene 1 (MTA1) expression in benign and malignant pancreatic endocrine tumors. (19377441)
2009
10
Heterogeneity of tumor prognostic markers: a reproducibility study applied to liver metastases of pancreatic endocrine tumors. (18997736)
2009
11
Proliferative rate in endoscopic ultrasound fine-needle aspiration of pancreatic endocrine tumors: correlation with clinical behavior. (19347828)
2009
12
VHL inactivation is an important pathway for the development of malignant sporadic pancreatic endocrine tumors. (19690016)
2009
13
CEACAM1 expression in pancreatic endocrine tumors. (19349857)
2009
14
Treatment of a pancreatic endocrine tumor by ethanol injection guided by endoscopic ultrasound. (19090457)
2008
15
Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors. (18927305)
2008
16
Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies. (18798544)
2008
17
Re: Treatment of a pancreatic endocrine tumor by ethanol injection (PEI) guided by endoscopic ultrasound. (19009494)
2008
18
Treatment of a pancreatic endocrine tumor by ethanol injection (PEI) guided by endoscopic ultrasound. (18633893)
2008
19
Pancreatic endocrine tumors-c-erb B2 (Her-2/neu), bcl-2, and p-53 immunohistochemical testing and their value in assessing prognosis. (18091321)
2008
20
Prognostic factors and survival in 324 patients with pancreatic endocrine tumor treated at a single institution. (19047107)
2008
21
Islet 1 (Isl1) expression is a reliable marker for pancreatic endocrine tumors and their metastases. (18300808)
2008
22
Mutational analysis of p27 (CDKN1B) and p18 (CDKN2C) in sporadic pancreatic endocrine tumors argues against tumor-suppressor function. (17710155)
2007
23
Management of nonfunctioning pancreatic endocrine tumors in the context of multiple endocrine neoplasia type 1 syndrome. (17925918)
2007
24
Lymphatic vessel endothelial hyaluronan receptor 1 immunocytochemical staining for pancreatic islets and pancreatic endocrine tumors. (18090227)
2007
25
Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. (17443844)
2007
26
Clinicopathologic and immunohistochemical correlation in sporadic pancreatic endocrine tumors: possible roles of utrophin and cyclin D1 in malignant progression. (17306326)
2007
27
Management of pancreatic endocrine tumors in multiple endocrine neoplasia type 1. (16680581)
2006
28
Pancreatic endocrine tumor with partial acinar cell differentiation. (17004975)
2006
29
Spindle cell pancreatic endocrine tumor associated with Cushing's syndrome. (16199900)
2005
30
Current advances in the diagnosis and treatment of pancreatic endocrine tumors. (15608508)
2005
31
Ectopic bioactive luteinizing hormone secretion by a pancreatic endocrine tumor, manifested as luteinized granulosa-thecal cell tumor of the ovaries. (15687346)
2005
32
Utility of combined use of plasma levels of chromogranin A and pancreatic polypeptide in the diagnosis of gastrointestinal and pancreatic endocrine tumors. (15053236)
2004
33
Frequent methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene in pancreatic endocrine tumors. (12629131)
2003
34
CpG island methylation in carcinoid and pancreatic endocrine tumors. (12584572)
2003
35
Immunohistochemical analysis of cyclooxygenase (COX)-2 expression in pancreatic endocrine tumors: association with tumor progression and proliferation. (11881729)
2001
36
Immunohistochemical expression of transforming growth factor alpha and epidermal growth factor receptor in pancreatic endocrine tumors. (11727256)
2001
37
Pancreatic endocrine tumors: recent advances. (10436815)
1999
38
Cellular composition and anatomic distribution in nonfunctioning pancreatic endocrine tumors: immunohistochemical study of 30 cases. (10374408)
1998
39
Pancreatic endocrine tumor with signet ring cell features: a case report with novel ultrastructural observations. (9615384)
1998
40
Lack of p53 immunoreactivity in pancreatic endocrine tumors. (8743819)
1996
41
A pancreatic endocrine tumor arising within a serous cystadenoma of the pancreas. (8604814)
1996
42
Immunolocalization of neuropeptide Y in human pancreatic endocrine tumors. (7479336)
1995
43
Multihormonal pancreatic endocrine tumor in a European lynx (Lynx lynx). (7725607)
1995
44
Acromegaly, diabetes insipidus, and visual loss caused by metastatic growth hormone-releasing hormone-producing malignant pancreatic endocrine tumor in the pituitary gland. Case report. (7674023)
1995
45
Glucagon-like peptide 1 immunoreactivity in gastroentero-pancreatic endocrine tumors: a light- and electron-microscopic study. (8062345)
1994
46
Islet amyloid polypeptide and calcitonin gene-related peptide immunoreactivity in amyloid and tumor cells of canine pancreatic endocrine tumors. (1972303)
1990
47
Factors that determine cell-specific gene expression in pancreatic endocrine tumor cells. (2559019)
1989
48
Multihormonal pancreatic endocrine tumor in a dog with duodenal ulcers and hypertrophic gastropathy. (2839924)
1988
49
Skeletal metastasis from gastrinoma. An uncommon manifestation of pancreatic endocrine tumor. (3791791)
1986
50
Pancreatic endocrine tumor presenting with obstructive jaundice. (6318554)
1984

Variations for Pancreatic Endocrine Tumors

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Expression for genes affiliated with Pancreatic Endocrine Tumors

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Endocrine Tumors

Search GEO for disease gene expression data for Pancreatic Endocrine Tumors.

Pathways for genes affiliated with Pancreatic Endocrine Tumors

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50PathCards, 53QIAGEN, 55Reactome, 38NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Pancreatic Endocrine Tumors

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29IUPHAR, 45Novoseek, 11DrugBank, 61Tocris Bioscience, 24HMDB
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Compounds related to Pancreatic Endocrine Tumors according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1bim 230592910.3SSTR2, SSTR5
2bim 230602910.3SSTR2, SSTR5
3[125i]tyr3 sms 201-9952910.2SSTR2, SSTR5
4bim 230562910.2SSTR5, SSTR2
5boc-ate2910.2SSTR5, SSTR2
6[111in,90y]dota-oc2910.2SSTR5, SSTR2
7l-363,3012910.2SSTR2, SSTR5
8noc-ate2910.2SSTR2, SSTR5
9[111in,90y]dota-lan2910.2SSTR2, SSTR5
10[111in,90y]dota-toc2910.2SSTR2, SSTR5
11bim 231972910.2SSTR5, SSTR2
12[111in]dota-boc-ate2910.2SSTR2, SSTR5
13bim 230232910.2SSTR2, SSTR5
14[111in]dota-noc2910.2SSTR2, SSTR5
15[111in]dota-noc-ate2910.2SSTR2, SSTR5
16mk-6782910.2SSTR2, SSTR5
17bim 230302910.2SSTR2, SSTR5
18[111in,90y]dota-noc2910.2SSTR2, SSTR5
19som-2302910.2SSTR5, SSTR2
20ke 1082910.2SSTR2, SSTR5
21l-362,8552910.2SSTR2, SSTR5
22bim 236272910.2SSTR2, SSTR5
23bim 234542910.2SSTR2, SSTR5
24[l-tyr8]cyn 1548062910.2SSTR2, SSTR5
25[d-tyr8]cyn 1548062910.2SSTR2, SSTR5
26pasireotide45 1111.2SSTR2, SSTR5
27cgp 239962910.1SSTR5, SSTR2
28[125i]ltt-srif-282910.1SSTR2, SSTR5
29[125i]tyr10-cst142910.1SSTR2, SSTR5
30srif-142910.1SSTR2, SSTR5
31srif-282910.1SSTR2, SSTR5
32bim 230522910.1SSTR5, SSTR2
33[125i]cgp 239962910.1SSTR5, SSTR2
34cst-172910.1SSTR5, SSTR2
35cst-142910.1SSTR5, SSTR2
36(1r,1s,3r/1r,1r,3s)-l-054,2646110.0SSTR5, SSTR2
37cyclosomatostatin6110.0SSTR5, SSTR2
38cyn 1548066110.0SSTR5, SSTR2
39somatostatin61 2411.0SSTR5, SSTR2
40vapreotide45 29 1112.0SSTR5, SSTR2
41111in-pentetreotide459.9SSTR5, SSTR2
42lanreotide45 2910.9SSTR5, SSTR2
43octreotide45 61 29 1112.7SSTR2, SSTR5
44alpha-ketoglutarate459.5EGLN2, HIF1AN
45thymidine45 2410.3MEN1, SSTR2, SSTR5
46dopamine45 29 24 1111.9ASCL1, SSTR5, SSTR2

GO Terms for genes affiliated with Pancreatic Endocrine Tumors

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16Gene Ontology
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Biological processes related to Pancreatic Endocrine Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to hypoxiaGO:0714569.5EGLN2, HIF1AN
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.5SSTR2, SSTR5
3forebrain neuron differentiationGO:0218799.5ASCL1, POU3F4
4regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.4HIF1AN, EGLN2
5negative regulation of cell proliferationGO:0082858.5CDKN2C, MEN1, SSTR2, SSTR5

Molecular functions related to Pancreatic Endocrine Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatostatin receptor activityGO:0049949.5SSTR2, SSTR5
2oxygen sensor activityGO:0198269.4HIF1AN, EGLN2
3sequence-specific DNA bindingGO:0435658.9MEN1, ASCL1, PAX4
4double-stranded DNA bindingGO:0036908.5MEN1, ASCL1, PAX4, POU3F4

Products for genes affiliated with Pancreatic Endocrine Tumors

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Sources for Pancreatic Endocrine Tumors

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet