MCID: PNC027
MIFTS: 30

Pancreatic Gastrinoma malady

Gastrointestinal diseases, Endocrine diseases, Cancer diseases categories

Summaries for Pancreatic Gastrinoma

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32MalaCards
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MalaCards: Pancreatic Gastrinoma, also known as pancreatic g-cell tumor, is related to gastrinoma and duodenitis. An important gene associated with Pancreatic Gastrinoma is PDX1 (pancreatic and duodenal homeobox 1). The compounds i-app and nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include lymph node, liver and pancreatic islet, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Pancreatic Gastrinoma

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases, Endocrine diseases


Aliases & Descriptions:

pancreatic gastrinoma 8 10 60
pancreatic g-cell tumor 8


External Ids:

Disease Ontology8 DOID:5580
NCIt39 C9069

Related Diseases for Pancreatic Gastrinoma

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17GeneCards, 18GeneDecks
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Diseases related to Pancreatic Gastrinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1gastrinoma30.7GAST
2duodenitis30.3GAST
3pancreatitis10.5
4duodenal gastrinoma10.2
5zollinger-ellison syndrome10.1
6multiple endocrine neoplasia10.0GAST
7diabetes mellitus10.0PDX1
8hyperinsulinemic hypoglycemia10.0GAST
9hypoglycemia10.0GAST
10glucagonoma10.0GAST, PDX1
11wermer syndrome10.0GAST, PPP2R5B
12insulinoma10.0GAST, PDX1

Graphical network of diseases related to Pancreatic Gastrinoma:



Diseases related to pancreatic gastrinoma

Clinical Features for Pancreatic Gastrinoma

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Drugs & Therapeutics for Pancreatic Gastrinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pancreatic Gastrinoma

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Anatomical Context for Pancreatic Gastrinoma

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32MalaCards
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MalaCards organs/tissues related to Pancreatic Gastrinoma:

32
Lymph node, Liver, Pancreatic islet, Spleen

Animal Models for Pancreatic Gastrinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pancreatic Gastrinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.0SHH, GAST, PDX1

Publications for Pancreatic Gastrinoma

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50PubMed
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Articles related to Pancreatic Gastrinoma:

(show all 23)
idTitleAuthorsYear
1
Percutaneous radiofrequency ablation approach through the spleen: initial case report for pancreatic tail gastrinoma. (20800027)
2010
2
Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas. (19240184)
2009
3
A rare surgical case of multiple liver resections for recurrent liver metastases from pancreatic gastrinoma: liver and vena cava resection. (19267257)
2009
4
Putative auto-infarct of a pancreatic gastrinoma: a case report. (19089667)
2007
5
Pancreatectomy in multiple endocrine neoplasia type 1-related gastrinomas and pancreatic endocrine neoplasias. (16794390)
2006
6
Gastrinoma (duodenal and pancreatic). (17312377)
2006
7
Zollinger-Ellison syndrome caused by solitary gastrinoma blocking the pancreatic duct: enucleation and pancreatic duct repair. (16003327)
2005
8
Pancreatic-polypeptide cell hyperplasia associated with pancreatic or duodenal gastrinomas. (9023394)
1997
9
Prospective study of surgical resection of duodenal and pancreatic gastrinomas in multiple endocrine neoplasia type 1. (7491542)
1995
10
Pancreatic polypeptide immunoreactivity in sporadic gastrinoma: relationship to intraabdominal location. (8532651)
1995
11
Duodenal gastrinoma: the solution to the pancreatic paradox. (7806825)
1994
12
Different splice variants of CD44 are expressed in gastrinomas but not in other subtypes of endocrine pancreatic tumors. (7508823)
1994
13
Multiple endocrine neoplasm, type 1. Gastrinomas, pancreatic neoplasms, microcarcinoids, the Zollinger-Ellison syndrome, lymph nodes, and hepatic metastases. (8105768)
1993
14
Gastrinoma presenting as chronic pancreatitis. (2301340)
1990
15
Gastrin in non-neoplastic pancreatic tissue from patients with and without gastrinomas. (2218398)
1990
16
Extrapancreatic gastrinoma with pancreatic islet cell hyperplasia. (2653274)
1989
17
Multiple endocrine neoplasia type II with Zollinger-Ellison syndrome caused by a solitary pancreatic gastrinoma. (2567786)
1989
18
Favourable response to conservative surgery for extra-pancreatic gastrinoma with lymph node metastases. (3567510)
1987
19
Skeletal metastasis from gastrinoma. An uncommon manifestation of pancreatic endocrine tumor. (3791791)
1986
20
A case of pancreatitis associated with gastrinoma. (3862397)
1985
21
Pancreatic islet cell tumors:insulinoma, gastrinoma, and glucagonoma. (220743)
1979
22
Is pancreatic polypeptide estimation of value in diagnosing gastrinomas (Zollinger-Ellison syndrome)? (292374)
1979
23
Antor-pyloric gastrinoma associated with pancreatic nesidioblastosis and proliferation of islets. (4201098)
1973

Genetic Variations for Pancreatic Gastrinoma

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Expression for genes affiliated with Pancreatic Gastrinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Gastrinoma

Search GEO for disease gene expression data for Pancreatic Gastrinoma.

Pathways for genes affiliated with Pancreatic Gastrinoma

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Compounds for genes affiliated with Pancreatic Gastrinoma

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44Novoseek, 11DrugBank
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Compounds related to Pancreatic Gastrinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1i-app449.6PDX1, GAST
2nicotinamide44 1110.5PDX1, GAST
3bromodeoxyuridine449.5PDX1, GAST
4c-peptide449.4GAST, PDX1
5neomycin449.2PDX1, GAST

GO Terms for genes affiliated with Pancreatic Gastrinoma

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16Gene Ontology
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Biological processes related to Pancreatic Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:0074179.5SHH, PDX1
2smoothened signaling pathwayGO:0072249.2SHH, PDX1

Products for genes affiliated with Pancreatic Gastrinoma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Pancreatic Gastrinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet