MCID: PNC027
MIFTS: 29

Pancreatic Gastrinoma malady

Gastrointestinal diseases, Cancer diseases, Endocrine diseases categories
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Summaries for Pancreatic Gastrinoma

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33MalaCards
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MalaCards: Pancreatic Gastrinoma, also known as pancreatic g-cell tumor, is related to gastrinoma and pancreatitis. An important gene associated with Pancreatic Gastrinoma is PDX1 (pancreatic and duodenal homeobox 1), and among its related pathways is GABA signaling in brain. The compounds i-app and nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include liver and lymph node, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Aliases & Classifications for Pancreatic Gastrinoma

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8Disease Ontology, 10DISEASES, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases, Endocrine diseases


Aliases & Descriptions:

pancreatic gastrinoma 8 10 62
pancreatic g-cell tumor 8


External Ids:

Disease Ontology8 DOID:5580
NCIt40 C9069

Related Diseases for Pancreatic Gastrinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pancreatic Gastrinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1gastrinoma10.5
2pancreatitis10.5
3duodenitis10.3
4multiple endocrine neoplasia10.3
5zollinger-ellison syndrome10.1
6wermer syndrome10.0PPP2R5B, GAST
7insulinoma10.0PDX1, GAST
8glucagonoma10.0GAST, PDX1
9pancreatic cancer9.9SHH, PDX1, GAST

Graphical network of diseases related to Pancreatic Gastrinoma:



Diseases related to pancreatic gastrinoma

Symptoms for Pancreatic Gastrinoma

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Drugs & Therapeutics for Pancreatic Gastrinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pancreatic Gastrinoma

Search NIH Clinical Center for Pancreatic Gastrinoma

Genetic Tests for Pancreatic Gastrinoma

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Anatomical Context for Pancreatic Gastrinoma

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33MalaCards
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MalaCards organs/tissues related to Pancreatic Gastrinoma:

33
Liver, Lymph node

Animal Models for Pancreatic Gastrinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pancreatic Gastrinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.9GAST, PDX1, SHH
2MP:00053818.8GAST, PDX1, SHH
3MP:00107688.1SHH, PDX1, NRXN2, GAST

Publications for Pancreatic Gastrinoma

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52PubMed
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Articles related to Pancreatic Gastrinoma:

idTitleAuthorsYear
1
Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas. (19240184)
2009
2
A rare surgical case of multiple liver resections for recurrent liver metastases from pancreatic gastrinoma: liver and vena cava resection. (19267257)
2009
3
Putative auto-infarct of a pancreatic gastrinoma: a case report. (19089667)
2007
4
Prospective study of surgical resection of duodenal and pancreatic gastrinomas in multiple endocrine neoplasia type 1. (7491542)
1995
5
Multiple endocrine neoplasia type II with Zollinger-Ellison syndrome caused by a solitary pancreatic gastrinoma. (2567786)
1989
6
Favourable response to conservative surgery for extra-pancreatic gastrinoma with lymph node metastases. (3567510)
1987

Variations for Pancreatic Gastrinoma

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Expression for genes affiliated with Pancreatic Gastrinoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Gastrinoma

Search GEO for disease gene expression data for Pancreatic Gastrinoma.

Pathways for genes affiliated with Pancreatic Gastrinoma

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50PathCards, 12EMD Millipore, 54R&D Systems
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Pathways related to Pancreatic Gastrinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5NRXN2, PDX1

Compounds for genes affiliated with Pancreatic Gastrinoma

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45Novoseek, 11DrugBank
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Compounds related to Pancreatic Gastrinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1i-app459.6GAST, PDX1
2nicotinamide45 1110.5GAST, PDX1
3bromodeoxyuridine459.5GAST, PDX1
4c-peptide459.4PDX1, GAST
5neomycin459.2GAST, PDX1

GO Terms for genes affiliated with Pancreatic Gastrinoma

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Sources:
16Gene Ontology
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Biological processes related to Pancreatic Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:0074179.4PDX1, SHH
2smoothened signaling pathwayGO:0072249.1PDX1, SHH

Products for genes affiliated with Pancreatic Gastrinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pancreatic Gastrinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet