MCID: PNC027
MIFTS: 37

Pancreatic Gastrinoma

Categories: Endocrine diseases, Gastrointestinal diseases, Cancer diseases

Aliases & Classifications for Pancreatic Gastrinoma

MalaCards integrated aliases for Pancreatic Gastrinoma:

Name: Pancreatic Gastrinoma 12 14 69
Pancreatic G-Cell Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5580
NCIt 46 C9069 C95596
UMLS 69 C1368066

Summaries for Pancreatic Gastrinoma

MalaCards based summary : Pancreatic Gastrinoma, also known as pancreatic g-cell tumor, is related to gastrinoma and gastrointestinal stromal tumor. An important gene associated with Pancreatic Gastrinoma is SCT (Secretin), and among its related pathways/superpathways are Signaling by GPCR and Neuroscience. The drugs Miconazole and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and lymph node, and related phenotypes are behavior/neurological and digestive/alimentary

Related Diseases for Pancreatic Gastrinoma

Diseases related to Pancreatic Gastrinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 gastrinoma 30.2 CHGA GAST MEN1 SCT SST
2 gastrointestinal stromal tumor 29.7 CHGA S100B SYP
3 multiple endocrine neoplasia, type i 28.9 CHGA GAST MEN1 PYGM SCT SST
4 zollinger-ellison syndrome 28.6 CHGA GAST GRP MEN1 SCT SST
5 hormone producing pituitary cancer 10.5 MEN1 SST
6 ureter small cell carcinoma 10.5 CHGA SYP
7 esophageal neuroendocrine tumor 10.5 CHGA SYP
8 ovarian large-cell neuroendocrine carcinoma 10.5 CHGA SYP
9 auditory system cancer 10.5 CHGA SYP
10 acinar cell cystadenocarcinoma 10.5 CHGA SYP
11 peritoneal serous adenocarcinoma 10.5 CHGA SYP
12 gallbladder small cell carcinoma 10.5 CHGA SYP
13 small cell carcinoma of the bladder 10.5 CHGA SYP
14 malignant glandular tumor of peripheral nerve sheath 10.5 SST SYP
15 gastrointestinal neuroendocrine tumor 10.5 CHGA SYP
16 pulmonary large cell neuroendocrine carcinoma 10.5 CHGA SYP
17 atypical follicular adenoma 10.5 CHGA SYP
18 epithelioid malignant peripheral nerve sheath tumor 10.5 CHGA S100B
19 non-functioning pituitary adenoma 10.4 S100B SST
20 pancreatic endocrine carcinoma 10.4 SST SYP
21 olfactory nerve neoplasm 10.4 CHGA SYP
22 sclerosing hepatic carcinoma 10.4 CHGA PTHLH
23 pancreatic serous cystadenoma 10.4 CHGA SYP
24 cauda equina neoplasm 10.4 CHGA SYP
25 mixed type thymoma 10.4 S100B SYP
26 pituitary carcinoma 10.4 CHGA SST
27 conventional angiosarcoma 10.4 CHGA SYP
28 hypoganglionosis 10.4 S100B SYP
29 glucagonoma 10.4 CHGA SCT SST
30 desmoplastic infantile ganglioglioma 10.4 GFAP SYP
31 extraventricular neurocytoma 10.4 GFAP SYP
32 pituitary adenoma, prolactin-secreting 10.4 GHSR MEN1 SST
33 lung combined type small cell carcinoma 10.4 GFAP SYP
34 autoimmune atrophic gastritis 10.4 CHGA GAST
35 spinal cancer 10.4 GFAP NRXN2
36 intracranial cysts 10.3 GFAP S100B
37 duodenum cancer 10.3 MEN1 SST SYP
38 gangliocytoma 10.3 GFAP SYP
39 rhabdoid meningioma 10.3 GFAP SYP
40 clear cell meningioma 10.3 CHGA GFAP
41 organ system benign neoplasm 10.3 MEN1 SST SYP
42 gemistocytic astrocytoma 10.3 GFAP S100B
43 functioning pituitary adenoma 10.3 MEN1 S100B SST
44 pilomyxoid astrocytoma 10.3 GFAP SYP
45 pylorospasm 10.3 GAST SST
46 thyroid cancer, nonmedullary, 2 10.3 CHGA MEN1 SST
47 ovarian small cell carcinoma 10.3 PTHLH SYP
48 central nervous system primitive neuroectodermal neoplasm 10.3 GFAP SYP
49 supratentorial primitive neuroectodermal tumor 10.3 S100B SYP
50 liver sarcoma 10.3 CHGA PTHLH

Graphical network of the top 20 diseases related to Pancreatic Gastrinoma:



Diseases related to Pancreatic Gastrinoma

Symptoms & Phenotypes for Pancreatic Gastrinoma

MGI Mouse Phenotypes related to Pancreatic Gastrinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.9 GFAP GHSR GRP NRXN2 PPY PTHLH
2 digestive/alimentary MP:0005381 9.56 GAST GFAP GHSR MEN1 PBX2 PTHLH
3 homeostasis/metabolism MP:0005376 9.36 CCKBR CHGA GAST GFAP GHSR MEN1

Drugs & Therapeutics for Pancreatic Gastrinoma

Drugs for Pancreatic Gastrinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Everolimus Approved Phase 2 159351-69-6 6442177
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
5
Octreotide Approved, Investigational Phase 2 83150-76-9 6400441 383414
6 Mitogens Phase 2
7 Angiogenesis Inhibitors Phase 2
8 Angiogenesis Modulating Agents Phase 2
9 Antibodies, Monoclonal Phase 2
10 Endothelial Growth Factors Phase 2
11 Anti-Bacterial Agents Phase 2
12 Anti-Infective Agents Phase 2
13 Antifungal Agents Phase 2
14 Immunoglobulins Phase 2
15 Immunosuppressive Agents Phase 2
16 Antibiotics, Antitubercular Phase 2
17 Liver Extracts Phase 2
18 Antibodies Phase 2
19 Gastrointestinal Agents Phase 2
20 Antineoplastic Agents, Hormonal Phase 2
21
Pancrelipase Approved, Investigational Phase 1 53608-75-6
22 pancreatin Phase 1
23 Hemostatics Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer Completed NCT01010126 Phase 2 Temsirolimus
2 Everolimus and Octreotide Acetate With or Without Bevacizumab in Treating Patients With Locally Advanced or Metastatic Pancreatic Neuroendocrine Tumors That Cannot Be Removed by Surgery Active, not recruiting NCT01229943 Phase 2 Everolimus;Octreotide Acetate
3 Laser Tissue Welding - Distal Pancreatectomy Sealing Study Recruiting NCT03147768 Phase 1

Search NIH Clinical Center for Pancreatic Gastrinoma

Genetic Tests for Pancreatic Gastrinoma

Anatomical Context for Pancreatic Gastrinoma

MalaCards organs/tissues related to Pancreatic Gastrinoma:

38
Liver, Endothelial, Lymph Node

Publications for Pancreatic Gastrinoma

Articles related to Pancreatic Gastrinoma:

# Title Authors Year
1
Management of pancreatic gastrinoma associated with Von Hippel-Lindau disease: a case report. ( 27055912 )
2016
2
An esophageal gastrointestinal stromal tumor in a patient with MEN1-related pancreatic gastrinoma: an unusual association and review of the literature. ( 25022420 )
2014
3
Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas. ( 19240184 )
2009
4
A rare surgical case of multiple liver resections for recurrent liver metastases from pancreatic gastrinoma: liver and vena cava resection. ( 19267257 )
2009
5
Putative auto-infarct of a pancreatic gastrinoma: a case report. ( 19089667 )
2007
6
Prospective study of surgical resection of duodenal and pancreatic gastrinomas in multiple endocrine neoplasia type 1. ( 7491542 )
1995
7
Multiple endocrine neoplasia type II with Zollinger-Ellison syndrome caused by a solitary pancreatic gastrinoma. ( 2567786 )
1989
8
Favourable response to conservative surgery for extra-pancreatic gastrinoma with lymph node metastases. ( 3567510 )
1987

Variations for Pancreatic Gastrinoma

Expression for Pancreatic Gastrinoma

Search GEO for disease gene expression data for Pancreatic Gastrinoma.

Pathways for Pancreatic Gastrinoma

Pathways related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 CCKBR GAST GFAP GHSR GRP MEN1
2 12.16 GAPDH GFAP S100B SYP
3 11.23 GFAP S100B SYP
4 9.65 CCKBR GAST
5 9.64 GAST GRP SCT

GO Terms for Pancreatic Gastrinoma

Cellular components related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 CHGA GAST GRP PPY PTHLH S100B

Biological processes related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.56 CCKBR GAST GHSR GRP PPY PTHLH
2 decidualization GO:0046697 9.43 GHSR MEN1
3 digestion GO:0007586 9.43 CCKBR PPY SST
4 response to food GO:0032094 9.4 GAST GHSR
5 regulation of neuronal synaptic plasticity GO:0048168 9.37 S100B SYP
6 osteoblast development GO:0002076 9.32 MEN1 PTHLH
7 regulation of receptor activity GO:0010469 9.17 GAST GRP PPP2R5B PPY PTHLH SCT
8 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway GO:1900738 9.16 CHGA GRP

Molecular functions related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.02 GAST PPY PTHLH SCT SST

Sources for Pancreatic Gastrinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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