MCID: PNC027
MIFTS: 29

Pancreatic Gastrinoma malady

Gastrointestinal diseases, Cancer diseases, Endocrine diseases categories

Summaries for Pancreatic Gastrinoma

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Sources:
34MalaCards
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MalaCards: Pancreatic Gastrinoma, also known as pancreatic g-cell tumor, is related to gastrinoma and pancreatitis. An important gene associated with Pancreatic Gastrinoma is PDX1 (pancreatic and duodenal homeobox 1), and among its related pathways is GABA signaling in brain. The compounds i-app and nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include liver and lymph node, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Aliases & Classifications for Pancreatic Gastrinoma

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases, Endocrine diseases


Aliases & Descriptions:

pancreatic gastrinoma 9 11 63
pancreatic g-cell tumor 9


External Ids:

Disease Ontology9 DOID:5580
NCIt41 C9069

Related Diseases for Pancreatic Gastrinoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Pancreatic Gastrinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1gastrinoma10.5
2pancreatitis10.5
3duodenitis10.3
4multiple endocrine neoplasia10.3
5zollinger-ellison syndrome10.1
6wermer syndrome10.0PPP2R5B, GAST
7insulinoma10.0PDX1, GAST
8glucagonoma10.0GAST, PDX1
9pancreatic cancer9.9SHH, PDX1, GAST

Graphical network of diseases related to Pancreatic Gastrinoma:



Diseases related to pancreatic gastrinoma

Symptoms for Pancreatic Gastrinoma

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Drugs & Therapeutics for Pancreatic Gastrinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Pancreatic Gastrinoma

Drug clinical trials:

Search ClinicalTrials for Pancreatic Gastrinoma

Search NIH Clinical Center for Pancreatic Gastrinoma

Search CenterWatch for Pancreatic Gastrinoma

Genetic Tests for Pancreatic Gastrinoma

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Anatomical Context for Pancreatic Gastrinoma

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Sources:
34MalaCards
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MalaCards organs/tissues related to Pancreatic Gastrinoma:

34
Liver, Lymph node

Animal Models for Pancreatic Gastrinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pancreatic Gastrinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.9GAST, PDX1, SHH
2MP:00053818.8GAST, PDX1, SHH
3MP:00107688.1SHH, PDX1, NRXN2, GAST

Publications for Pancreatic Gastrinoma

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53PubMed
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Articles related to Pancreatic Gastrinoma:

idTitleAuthorsYear
1
Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas. (19240184)
2009
2
A rare surgical case of multiple liver resections for recurrent liver metastases from pancreatic gastrinoma: liver and vena cava resection. (19267257)
2009
3
Putative auto-infarct of a pancreatic gastrinoma: a case report. (19089667)
2007
4
Prospective study of surgical resection of duodenal and pancreatic gastrinomas in multiple endocrine neoplasia type 1. (7491542)
1995
5
Multiple endocrine neoplasia type II with Zollinger-Ellison syndrome caused by a solitary pancreatic gastrinoma. (2567786)
1989
6
Favourable response to conservative surgery for extra-pancreatic gastrinoma with lymph node metastases. (3567510)
1987

Variations for Pancreatic Gastrinoma

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Expression for genes affiliated with Pancreatic Gastrinoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Gastrinoma

Search GEO for disease gene expression data for Pancreatic Gastrinoma.

Pathways for genes affiliated with Pancreatic Gastrinoma

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Sources:
51PathCards, 13EMD Millipore, 55R&D Systems
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Pathways related to Pancreatic Gastrinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5NRXN2, PDX1

Compounds for genes affiliated with Pancreatic Gastrinoma

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Sources:
46Novoseek, 12DrugBank
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Compounds related to Pancreatic Gastrinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1i-app469.6GAST, PDX1
2nicotinamide46 1210.5GAST, PDX1
3bromodeoxyuridine469.5GAST, PDX1
4c-peptide469.4PDX1, GAST
5neomycin469.2GAST, PDX1

GO Terms for genes affiliated with Pancreatic Gastrinoma

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Sources:
17Gene Ontology
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Biological processes related to Pancreatic Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:0074179.4PDX1, SHH
2smoothened signaling pathwayGO:0072249.1PDX1, SHH

Products for genes affiliated with Pancreatic Gastrinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pancreatic Gastrinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet