MCID: PNC027
MIFTS: 30

Pancreatic Gastrinoma malady

Cancer diseases, Gastrointestinal diseases, Endocrine diseases categories
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Summaries for Pancreatic Gastrinoma

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MalaCards based summary: Pancreatic Gastrinoma, also known as pancreatic g-cell tumor, is related to gastrinoma and pancreatitis. An important gene associated with Pancreatic Gastrinoma is PDX1 (pancreatic and duodenal homeobox 1), and among its related pathways is GABA signaling in brain. The compounds i-app and nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include liver and lymph node, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Aliases & Classifications for Pancreatic Gastrinoma

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Pancreatic Gastrinoma, Aliases & Descriptions:

Name: Pancreatic Gastrinoma 8 10 62
 
Pancreatic G-Cell Tumor 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases, Endocrine diseases


External Ids:

Disease Ontology8 DOID:5580
NCIt39 C9069

Related Diseases for Pancreatic Gastrinoma

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Diseases related to Pancreatic Gastrinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1gastrinoma10.6
2pancreatitis10.6
3duodenitis10.3
4multiple endocrine neoplasia10.3
5gastrointestinal stromal tumor10.1
6zollinger-ellison syndrome10.1
7esophagitis10.1
8wermer syndrome10.0PPP2R5B, GAST
9insulinoma10.0PDX1, GAST
10glucagonoma10.0GAST, PDX1
11pancreatic cancer9.5SHH, PDX1, GAST

Graphical network of diseases related to Pancreatic Gastrinoma:



Diseases related to pancreatic gastrinoma

Symptoms for Pancreatic Gastrinoma

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Drugs & Therapeutics for Pancreatic Gastrinoma

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Drug clinical trials:

Search ClinicalTrials for Pancreatic Gastrinoma

Search NIH Clinical Center for Pancreatic Gastrinoma

Genetic Tests for Pancreatic Gastrinoma

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Anatomical Context for Pancreatic Gastrinoma

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MalaCards organs/tissues related to Pancreatic Gastrinoma:

32
Liver, Lymph node

Animal Models for Pancreatic Gastrinoma or affiliated genes

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MGI Mouse Phenotypes related to Pancreatic Gastrinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.9GAST, SHH, PDX1
2MP:00053818.8SHH, PDX1, GAST
3MP:00107688.1GAST, SHH, PDX1, NRXN2

Publications for Pancreatic Gastrinoma

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Articles related to Pancreatic Gastrinoma:

idTitleAuthorsYear
1
An esophageal gastrointestinal stromal tumor in a patient with MEN1-related pancreatic gastrinoma: an unusual association and review of the literature. (25022420)
2014
2
Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas. (19240184)
2009
3
A rare surgical case of multiple liver resections for recurrent liver metastases from pancreatic gastrinoma: liver and vena cava resection. (19267257)
2009
4
Putative auto-infarct of a pancreatic gastrinoma: a case report. (19089667)
2007
5
Prospective study of surgical resection of duodenal and pancreatic gastrinomas in multiple endocrine neoplasia type 1. (7491542)
1995
6
Multiple endocrine neoplasia type II with Zollinger-Ellison syndrome caused by a solitary pancreatic gastrinoma. (2567786)
1989
7
Favourable response to conservative surgery for extra-pancreatic gastrinoma with lymph node metastases. (3567510)
1987

Variations for Pancreatic Gastrinoma

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Expression for genes affiliated with Pancreatic Gastrinoma

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Expression patterns in normal tissues for genes affiliated with Pancreatic Gastrinoma

Search GEO for disease gene expression data for Pancreatic Gastrinoma.

Pathways for genes affiliated with Pancreatic Gastrinoma

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Pathways related to Pancreatic Gastrinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5NRXN2, PDX1

Compounds for genes affiliated with Pancreatic Gastrinoma

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Sources:
44Novoseek, 11DrugBank
See all sources

Compounds related to Pancreatic Gastrinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1i-app449.6PDX1, GAST
2nicotinamide44 1110.5PDX1, GAST
3bromodeoxyuridine449.5PDX1, GAST
4c-peptide449.4GAST, PDX1
5neomycin449.2PDX1, GAST

GO Terms for genes affiliated with Pancreatic Gastrinoma

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Biological processes related to Pancreatic Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:0074179.4PDX1, SHH
2smoothened signaling pathwayGO:0072249.1PDX1, SHH

Products for genes affiliated with Pancreatic Gastrinoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Pancreatic Gastrinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet