MCID: PNC027
MIFTS: 25

Pancreatic Gastrinoma malady

Gastrointestinal diseases, Endocrine diseases, Cancer diseases categories

Aliases & Classifications for Pancreatic Gastrinoma

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Aliases & Descriptions for Pancreatic Gastrinoma:

Name: Pancreatic Gastrinoma 8 10 61
 
Pancreatic G-Cell Tumor 8


Classifications:



External Ids:

Disease Ontology8 DOID:5580
NCIt39 C9069

Summaries for Pancreatic Gastrinoma

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MalaCards based summary: Pancreatic Gastrinoma, also known as pancreatic g-cell tumor, is related to gastrinoma and pancreatitis. An important gene associated with Pancreatic Gastrinoma is PDX1 (pancreatic and duodenal homeobox 1), and among its related pathways is GABA signaling in brain. The compounds i-app and nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include liver and lymph node, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Related Diseases for Pancreatic Gastrinoma

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Diseases related to Pancreatic Gastrinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1gastrinoma10.6
2pancreatitis10.6
3duodenitis10.3
4multiple endocrine neoplasia10.3
5gastrointestinal stromal tumor10.1
6zollinger-ellison syndrome10.1
7esophagitis10.1
8multiple endocrine neoplasia 110.0PPP2R5B, GAST
9insulinoma10.0PDX1, GAST
10glucagonoma10.0GAST, PDX1
11pancreatic cancer9.5SHH, PDX1, GAST

Graphical network of diseases related to Pancreatic Gastrinoma:



Diseases related to pancreatic gastrinoma

Symptoms for Pancreatic Gastrinoma

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Drugs & Therapeutics for Pancreatic Gastrinoma

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Drug clinical trials:

Search ClinicalTrials for Pancreatic Gastrinoma

Search NIH Clinical Center for Pancreatic Gastrinoma

Genetic Tests for Pancreatic Gastrinoma

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Anatomical Context for Pancreatic Gastrinoma

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MalaCards organs/tissues related to Pancreatic Gastrinoma:

31
Liver, Lymph node

Animal Models for Pancreatic Gastrinoma or affiliated genes

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MGI Mouse Phenotypes related to Pancreatic Gastrinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.9GAST, PDX1, SHH
2MP:00053818.8GAST, PDX1, SHH
3MP:00107688.1SHH, PDX1, NRXN2, GAST

Publications for Pancreatic Gastrinoma

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Articles related to Pancreatic Gastrinoma:

idTitleAuthorsYear
1
An esophageal gastrointestinal stromal tumor in a patient with MEN1-related pancreatic gastrinoma: an unusual association and review of the literature. (25022420)
2014
2
Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas. (19240184)
2009
3
A rare surgical case of multiple liver resections for recurrent liver metastases from pancreatic gastrinoma: liver and vena cava resection. (19267257)
2009
4
Putative auto-infarct of a pancreatic gastrinoma: a case report. (19089667)
2007
5
Prospective study of surgical resection of duodenal and pancreatic gastrinomas in multiple endocrine neoplasia type 1. (7491542)
1995
6
Multiple endocrine neoplasia type II with Zollinger-Ellison syndrome caused by a solitary pancreatic gastrinoma. (2567786)
1989
7
Favourable response to conservative surgery for extra-pancreatic gastrinoma with lymph node metastases. (3567510)
1987

Variations for Pancreatic Gastrinoma

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Expression for genes affiliated with Pancreatic Gastrinoma

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Search GEO for disease gene expression data for Pancreatic Gastrinoma.

Pathways for genes affiliated with Pancreatic Gastrinoma

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Pathways related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes

Compounds for genes affiliated with Pancreatic Gastrinoma

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Sources:
44Novoseek, 11DrugBank
See all sources

Compounds related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1i-app449.6GAST, PDX1
2nicotinamide44 1110.5GAST, PDX1
3bromodeoxyuridine449.5GAST, PDX1
4c-peptide449.4PDX1, GAST
5neomycin449.2GAST, PDX1

GO Terms for genes affiliated with Pancreatic Gastrinoma

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Biological processes related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:00074179.4PDX1, SHH
2smoothened signaling pathwayGO:00072249.1PDX1, SHH

Sources for Pancreatic Gastrinoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet