MCID: PNC027
MIFTS: 26

Pancreatic Gastrinoma malady

Gastrointestinal, Endocrine, Cancer categories

Summaries for Pancreatic Gastrinoma

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33MalaCards
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MalaCards: Pancreatic Gastrinoma, also known as pancreatic g-cell tumor, is related to gastrinoma and multiple endocrine neoplasia. An important gene associated with Pancreatic Gastrinoma is PDX1 (pancreatic and duodenal homeobox 1). The compounds i-app and nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and spleen, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Pancreatic Gastrinoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal, Endocrine


Aliases & Descriptions:

pancreatic gastrinoma 8 10 61
pancreatic g-cell tumor 8


External Ids:

Disease Ontology8 DOID:5580
NCIt40 C9069

Related Diseases for Pancreatic Gastrinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pancreatic Gastrinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1gastrinoma30.7GAST
2multiple endocrine neoplasia30.4GAST
3duodenal gastrinoma10.3
4n syndrome10.1
5zollinger-ellison syndrome10.1
6pancreatitis, chronic10.1
7duodenitis10.0GAST
8diabetes mellitus10.0PDX1
9hyperinsulinemic hypoglycemia10.0GAST
10hypoglycemia10.0GAST
11glucagonoma10.0PDX1, GAST
12wermer syndrome10.0GAST, PPP2R5B
13insulinoma10.0GAST, PDX1

Graphical network of diseases related to Pancreatic Gastrinoma:



Diseases related to pancreatic gastrinoma

Clinical Features for Pancreatic Gastrinoma

Drugs & Therapeutics for Pancreatic Gastrinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pancreatic Gastrinoma

Drug clinical trials:

Search ClinicalTrials for Pancreatic Gastrinoma

Search NIH Clinical Center for Pancreatic Gastrinoma

Search CenterWatch for Pancreatic Gastrinoma

Genetic Tests for Pancreatic Gastrinoma

Anatomical Context for Pancreatic Gastrinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Pancreatic Gastrinoma:

33
Liver, Lymph node, Spleen, Pancreatic islet

Animal Models for Pancreatic Gastrinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Pancreatic Gastrinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.0SHH, GAST, PDX1

Publications for Pancreatic Gastrinoma

Sources:
51PubMed
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Articles related to Pancreatic Gastrinoma:

(show all 23)
idTitleAuthorsYear
1
Partial pancreaticoduodenectomy can provide cure for duodenal gastrinoma associated with multiple endocrine neoplasia type 1. (22580937)
2013
2
Percutaneous radiofrequency ablation approach through the spleen: initial case report for pancreatic tail gastrinoma. (20800027)
2010
3
Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas. (19240184)
2009
4
A rare surgical case of multiple liver resections for recurrent liver metastases from pancreatic gastrinoma: liver and vena cava resection. (19267257)
2009
5
Five-Year Long-Term Followup of a Primary Lymph node Gastrinoma: Is a Pancreaticoduodenectomy Justified? (19724657)
2009
6
Putative auto-infarct of a pancreatic gastrinoma: a case report. (19089667)
2007
7
Pancreatectomy in multiple endocrine neoplasia type 1-related gastrinomas and pancreatic endocrine neoplasias. (16794390)
2006
8
Gastrinoma (duodenal and pancreatic). (17312377)
2006
9
Zollinger-Ellison syndrome caused by solitary gastrinoma blocking the pancreatic duct: enucleation and pancreatic duct repair. (16003327)
2005
10
Pancreatic-polypeptide cell hyperplasia associated with pancreatic or duodenal gastrinomas. (9023394)
1997
11
Prospective study of surgical resection of duodenal and pancreatic gastrinomas in multiple endocrine neoplasia type 1. (7491542)
1995
12
Pancreatic polypeptide immunoreactivity in sporadic gastrinoma: relationship to intraabdominal location. (8532651)
1995
13
Duodenal gastrinoma: the solution to the pancreatic paradox. (7806825)
1994
14
Different splice variants of CD44 are expressed in gastrinomas but not in other subtypes of endocrine pancreatic tumors. (7508823)
1994
15
Multiple endocrine neoplasm, type 1. Gastrinomas, pancreatic neoplasms, microcarcinoids, the Zollinger-Ellison syndrome, lymph nodes, and hepatic metastases. (8105768)
1993
16
Gastrin in non-neoplastic pancreatic tissue from patients with and without gastrinomas. (2218398)
1990
17
Extrapancreatic gastrinoma with pancreatic islet cell hyperplasia. (2653274)
1989
18
Multiple endocrine neoplasia type II with Zollinger-Ellison syndrome caused by a solitary pancreatic gastrinoma. (2567786)
1989
19
Favourable response to conservative surgery for extra-pancreatic gastrinoma with lymph node metastases. (3567510)
1987
20
Skeletal metastasis from gastrinoma. An uncommon manifestation of pancreatic endocrine tumor. (3791791)
1986
21
Pancreatic islet cell tumors:insulinoma, gastrinoma, and glucagonoma. (220743)
1979
22
Is pancreatic polypeptide estimation of value in diagnosing gastrinomas (Zollinger-Ellison syndrome)? (292374)
1979
23
Antor-pyloric gastrinoma associated with pancreatic nesidioblastosis and proliferation of islets. (4201098)
1973

Genetic Variations for Pancreatic Gastrinoma

Expression for genes affiliated with Pancreatic Gastrinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Gastrinoma

Search GEO for disease gene expression data for Pancreatic Gastrinoma.

Pathways for genes affiliated with Pancreatic Gastrinoma

Compounds for genes affiliated with Pancreatic Gastrinoma

Sources:
45Novoseek, 11DrugBank
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Compounds related to Pancreatic Gastrinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1i-app459.6GAST, PDX1
2nicotinamide45 1110.5GAST, PDX1
3bromodeoxyuridine459.5GAST, PDX1
4c-peptide459.4PDX1, GAST
5neomycin459.2GAST, PDX1

GO Terms for genes affiliated with Pancreatic Gastrinoma

Sources:
16Gene Ontology
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Biological processes related to Pancreatic Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:0074179.5SHH, PDX1
2smoothened signaling pathwayGO:0072249.2SHH, PDX1

Products for genes affiliated with Pancreatic Gastrinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pancreatic Gastrinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet