MCID: PNC053
MIFTS: 46

Pancreatic Islet Cell Tumors malady

Rare diseases, Endocrine diseases, Cancer diseases categories

Aliases & Classifications for Pancreatic Islet Cell Tumors

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Pancreatic Islet Cell Tumors, Aliases & Descriptions:

Name: Pancreatic Islet Cell Tumors 41 60
Pancreatic Endocrine Carcinoma 60
Islet of Langerhans Tumor 41
 
Islet Cell Carcinoma 41
Islet Cell Tumors 41
Islet Cell Tumor 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Summaries for Pancreatic Islet Cell Tumors

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MalaCards based summary: Pancreatic Islet Cell Tumors, also known as pancreatic endocrine carcinoma, is related to islet cell tumor and duodenitis. An important gene associated with Pancreatic Islet Cell Tumors is GHRHR (growth hormone releasing hormone receptor), and among its related pathways are Regulation of beta-cell development and ADP signalling through P2Y purinoceptor 12. The drug dacarbazine and the compounds mibg and lafutidine have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, liver and pituitary, and related mouse phenotypes are no phenotypic analysis and renal/urinary system.

Related Diseases for Pancreatic Islet Cell Tumors

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Diseases related to Pancreatic Islet Cell Tumors via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1islet cell tumor32.3SST, GAST
2duodenitis31.1GAST
3hypokalemia30.9INS, VIP
4acinar cell carcinoma30.7CHGA, GAST
5pancreatic cholera30.6VIP, SST
6vipoma30.6VIP, SST, CALCA
7cushing's syndrome30.6GHRH, SST, INS
8hyperinsulinism30.4SST, INS, IGF2
9cholera30.4INS, VIP, NTS, CALCA
10hypercalcemia30.3CHGA, IAPP, MEN1, CALCA, GAST
11zollinger-ellison syndrome30.3CHGA, SST, GAST, GHRH, MEN1
12multiple endocrine neoplasia30.3VIP, CHGA, RET, MEN1, CALCA, GAST
13obesity30.3INS, IAPP, NTS, GHRH
14duodenal ulcer30.3INS, SST, GAST
15hyperglycemia30.1INS, IAPP, SST, GHRH
16diarrhea30.1INS, VIP, CHGA, SST, CALCA, GAST
17hyperparathyroidism30.1CHGA, RET, MEN1, CALCA, GAST
18glucagonoma30.0GAST, GHRH, MEN1, SST, CHGA, VIP
19gastrinoma30.0VIP, CHGA, IAPP, SST, MEN1, GAST
20neuroendocrine tumor30.0CHGA, SST, MEN1, CALCA, GAST
21thyroid cancer30.0CALCA, SST, RET, CHGA
22primary hyperparathyroidism29.9CHGA, RET, MEN1, CALCA, GAST
23somatostatinoma29.9GAST, CALCA, GHRH, SST, CHGA, VIP
24pheochromocytoma29.8VIP, CHGA, CALCA, NTS, MEN1, SST
25hepatocellular carcinoma29.7MEN1, VIP, INS, IGF2
26hypoglycemia29.7IGF2, INS, CHGA, IAPP, SST, GHRH
27acromegaly29.7GHRHR, GHRH, MEN1, SST, VIP, INS
28adenocarcinoma29.4POU1F1, VIP, CHGA, IAPP, SST, MEN1
29insulinoma28.5GAST, CALCA, INS, VIP, CHGA, IAPP
30adenoma28.4GAST, CALCA, GHRHR, GHRH, NTS, MEN1
31pancreatitis11.3
32pheochromocytoma-islet cell tumor syndrome10.6
33pernicious anemia10.5GAST
34spinal stenosis10.4CALCA
35gigantism10.4SST
36neuroblastoma10.4NTS, VIP
37intestinal disease10.4SST
38thyroiditis10.4
39duodenogastric reflux10.4NTS, GAST
40cowden disease10.4RET
41dumping syndrome10.3SST, NTS
42gastroesophageal reflux10.3GAST, NTS
43esophagitis10.3GAST, NTS
44pituitary hypoplasia10.3POU1F1, GHRH, GHRHR
45dwarfism10.3GHRHR, GHRH, POU1F1
46achalasia10.3VIP, GAST
47cluster headache10.3VIP, CALCA
48gastrointestinal stromal tumor10.3
49portal hypertension10.3
50mahvash disease10.3

Graphical network of the top 20 diseases related to Pancreatic Islet Cell Tumors:



Diseases related to pancreatic islet cell tumors

Symptoms for Pancreatic Islet Cell Tumors

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Drugs & Therapeutics for Pancreatic Islet Cell Tumors

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Drug clinical trials:

Search ClinicalTrials for Pancreatic Islet Cell Tumors

Search NIH Clinical Center for Pancreatic Islet Cell Tumors

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Pancreatic Islet Cell Tumors

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Anatomical Context for Pancreatic Islet Cell Tumors

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MalaCards organs/tissues related to Pancreatic Islet Cell Tumors:

31
Pancreatic islet, Liver, Pituitary, Testes

Animal Models for Pancreatic Islet Cell Tumors or affiliated genes

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MGI Mouse Phenotypes related to Pancreatic Islet Cell Tumors:

35 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030127.8NTS, SST, RET, INS, IGF2
2MP:00053677.5IGF2, INS, CHGA, RET, CALCA
3MP:00053817.3IGF2, INS, RET, SST, MEN1, GAST
4MP:00053857.0IGF2, INS, VIP, CHGA, RET, MEN1
5MP:00053866.9IGF2, INS, VIP, RET, SST, NTS
6MP:00053896.9IGF2, INS, POU1F1, VIP, CHGA, RET
7MP:00036316.4IGF2, INS, POU1F1, RET, SST, MEN1
8MP:00053796.4IGF2, INS, POU1F1, VIP, CHGA, RET
9MP:00107686.3IGF2, INS, POU1F1, VIP, CHGA, RET
10MP:00053786.2CHGA, POU1F1, INS, IGF2, IAPP, RET
11MP:00053876.0VIP, POU1F1, INS, IGF2, IAPP, RET
12MP:00053765.0GAST, IGF2, INS, POU1F1, VIP, CHGA

Publications for Pancreatic Islet Cell Tumors

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Articles related to Pancreatic Islet Cell Tumors:

(show top 50)    (show all 95)
idTitleAuthorsYear
1
Characterization of a pancreatic islet cell tumor in a polar bear (Ursus maritimus). (25273481)
2014
2
Surgical treatment of pancreatic islet cell tumor: report of 44 cases. (24719954)
2013
3
Pancreatic islet cell tumor secreting insulin-like growth factor type-II in a dog. (19780935)
2009
4
Spontaneous pancreatic islet cell tumor in a black and white colobus monkey (Colobus guereza kikuyuensis). (18269522)
2008
5
Multi-detector row CT of pancreatic islet cell tumors. (16549609)
2006
6
Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989-1999). (12322919)
2002
7
High frequency loss of heterozygosity in von Hippel-Lindau (VHL)-associated and sporadic pancreatic islet cell tumors: evidence for a stepwise mechanism for malignant conversion in VHL tumorigenesis. (11929809)
2002
8
Induction of pancreatic islet cell tumors in rats by repeated intravenous administration of 4-hydroxyaminoquinoline 1-oxide. (11442018)
2001
9
Evaluation of pancreatic islet cell tumors by fluorine-18 fluorodeoxyglucose positron emission tomography: comparison with other modalities. (10656646)
2000
10
Functional pancreatic islet cell tumors with liver metastasis: the role of cytoreductive surgery and transcatheter arterial chemoembolization: a report of five cases. (9884450)
1998
11
Surgical decision-making affected by clinical and genetic screening of a novel kindred with von Hippel-Lindau disease and pancreatic islet cell tumors. (9488521)
1998
12
Immunohistochemistry of pancreatic islet cell tumors in the ferret (Mustela putorius furo). (9381649)
1997
13
Pancreatic islet cell tumor producing vasoactive intestinal polypeptide and calcitonin. (9494586)
1997
14
A growth hormone-releasing hormone-producing pancreatic islet cell tumor metastasized to the pituitary is associated with pituitary somatotroph hyperplasia and acromegaly. (9253362)
1997
15
Chromogranin A plasma concentration and expression in pancreatic islet cell tumors of dogs and cats. (9185968)
1997
16
Absence of RET proto-oncogene mutations in a father and son with pheochromocytoma and pancreatic islet cell tumor. (9179691)
1997
17
The concurrence of duodenal epithelioid stromal sarcoma, pulmonary chondromatous hamartoma, and nonfunctioning pancreatic islet cell tumor. A possible analogue of Carney's triad? (8060238)
1994
18
Surgical experience with pancreatic islet-cell tumors. (8105769)
1993
19
Islet amyloid polypeptide-producing pancreatic islet cell tumor. A clinical and biochemical characterization. (1326785)
1992
20
Pancreatic islet cell tumors metastatic to the liver: treatment by hepatic artery chemo-embolization. (2559021)
1989
21
Hyperinsulinism and hypoglycemia associated with pancreatic islet cell tumor in a ferret. (2537277)
1989
22
Endoscopic retrograde cholangiopancreatography in pancreatic islet cell tumors. (2832244)
1988
23
Pancreatic islet cell tumors. (3029883)
1987
24
Radiotherapy in the management of pancreatic islet cell tumors. (3040209)
1987
25
Thyrotropin-releasing hormone and insulin in chemically induced pancreatic islet cell tumors in rats. (3023223)
1986
26
Acromegaly due to secretion of growth hormone by an ectopic pancreatic islet-cell tumor. (2981107)
1985
27
Serum levels of alpha-1-antitrypsin in pancreatic islet cell tumors. (6098624)
1984
28
Computed tomography and nuclear magnetic resonance imaging of pancreatic islet cell tumors. (6316575)
1983
29
Metastasizing pancreatic islet cell tumors in the rat. (6279704)
1982
30
Ultrasonic demonstration of small pancreatic islet cell tumors. (6282939)
1982
31
Selective growth hormone and cyclic AMP stimulating activity is present in human pancreatic islet cell tumor. (6123522)
1982
32
Ultrasonic investigation of pancreatic islet cell tumors. (6302303)
1982
33
Rupture of a giant non-functioning pancreatic islet cell tumor following minimal trauma. (6258461)
1981
34
Calcium stimulation test in the evaluation of insulin secreting pancreatic islet cell tumors: case reports. (6259559)
1981
35
Pancreatic islet cell tumors found in rats given alloxan and nicotinamide. (6254753)
1980
36
Pancreatic islet cell tumors:insulinoma, gastrinoma, and glucagonoma. (220743)
1979
37
Coexistence of bilateral pheochromocytoma and pancreatic islet cell tumor: report of a case and review of the literature. (215301)
1978
38
Endocrine surgery. Pancreatic islet cell tumor presenting as hyperparathyroidism. (206637)
1978
39
Pheochromocytoma with prominent calcification and associated pancreatic islet cell tumor. (199750)
1977
40
Pancreatic islet cell tumors: a brief review. (183636)
1976
41
Pancreatic islet cell tumors in domestic animals. Data from 11 colleges of veterinary medicine in the United States and Canada. (4365909)
1974
42
Hormone-producing pancreatic islet-cell tumors and hyperplasia. (4345017)
1972
43
Plasma proinsulin in patients with functioning pancreatic islet cell tumors. (4342038)
1972
44
Endocrine syndromes associated with pancreatic islet cell tumors. (4298136)
1968
45
DIARRHEA ASSOCIATED WITH PANCREATIC ISLET-CELL TUMORS. (14116905)
1964
46
PANCREATIC ISLET CELL TUMOR IN A DOG. (14238882)
1964
47
Effects of extracts of primary and metastatic pancreatic islet cell tumors on gastric secretion. (13952167)
1963
48
Pancreatic islet cell tumors and renal tumors in the male rat following neutron exposure. (14493916)
1962
49
Pancreatic islet cell tumors and renal tumors in the male rat following neutron exposure. (14038763)
1961
50
Clinics on endocrine and metabolic diseases. 3. Hyperinsulinism: review of 95 cases of functioning pancreatic islet cell tumors. (13748469)
1960

Variations for Pancreatic Islet Cell Tumors

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Expression for genes affiliated with Pancreatic Islet Cell Tumors

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Search GEO for disease gene expression data for Pancreatic Islet Cell Tumors.

Pathways for genes affiliated with Pancreatic Islet Cell Tumors

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Pathways related to Pancreatic Islet Cell Tumors according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4INS, IAPP
2
Show member pathways
9.2CALCA, IAPP, GHRH, GHRHR
38.9CALCA, GHRHR, GHRH, IAPP, VIP
4
Show member pathways
8.5NTS, IAPP, SST, CALCA, GHRHR, GHRH
5
Show member pathways
5.9IGF2, VIP, IAPP, SST, MEN1, NTS

Compounds for genes affiliated with Pancreatic Islet Cell Tumors

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Compounds related to Pancreatic Islet Cell Tumors according to GeneCards Suite gene sharing:

(show top 50)    (show all 167)
idCompoundScoreTop Affiliating Genes
1mibg439.2CALCA, SST, CHGA, VIP
2lafutidine439.2CALCA, GAST, SST
3minigastrin439.2GAST, SST, VIP
4loxiglumide439.1SST, NTS, GAST
5naloxone43 28 49 1212.1SST, VIP, NTS, GHRH
65-hydroxyindoleacetic acid43 2410.1VIP, GAST, CHGA, SST
7clonidine43 49 28 1212.0GHRH, NTS, CALCA, SST, CHGA
8111in-pentetreotide439.0SST, CALCA, CHGA
9calcium gluconate438.9INS, GAST, CALCA
10oxyntomodulin43 599.9NTS, GAST, SST, CHGA, VIP
11catecholamine438.9NTS, RET, IAPP, VIP, CHGA
12bromocriptine43 28 1210.8SST, GHRH, VIP, POU1F1, IGF2
13i-app438.8GAST, CALCA, IAPP, INS
14carbachol43 28 1210.7SST, GAST, NTS, CHGA, VIP
15nifedipine43 28 49 1211.6VIP, GAST, GHRH, NTS, SST, CHGA
16atropine43 28 1210.6GAST, VIP, SST, GHRH, NTS, CALCA
17corticosterone43 59 2410.5IGF2, VIP, GAST, CALCA, NTS
18propranolol43 28 49 24 1212.5VIP, SST, GHRH, CALCA, GAST, CHGA
195-hydroxytryptamine438.5GAST, CALCA, NTS, SST, CHGA, VIP
20ribonucleic acid438.4GHRH, CHGA, POU1F1, IGF2, RET, GHRHR
21isoproterenol43 129.2SST, CALCA, NTS, GAST, CHGA, VIP
22acetylcholine43 49 28 24 1212.2GAST, VIP, CHGA, IAPP, SST, NTS
23vitamin d438.1GHRH, IGF2, POU1F1, CALCA, GAST, CHGA
24thymidine43 249.1IGF2, VIP, IAPP, MEN1, NTS, GAST
25ibmx43 59 289.9CALCA, SST, IAPP, VIP, INS, IGF2
26hydrocortisone43 2 59 1210.8CALCA, GAST, INS, SST, IGF2
27cyclic amp43 248.8POU1F1, VIP, CHGA, IAPP, RET, NTS
28pge2437.8GAST, CALCA, SST, VIP, IGF2, NTS
29forskolin43 49 129.7NTS, CALCA, GHRHR, GHRH, IGF2, VIP
30histamine43 28 249.6IAPP, IGF2, SST, VIP, NTS, CALCA
31c-peptide437.6GAST, NTS, IGF2, INS, CHGA, IAPP
32lactate437.4SST, CALCA, IAPP, CHGA, IGF2, INS
33epinephrine43 24 129.4CHGA, IAPP, SST, NTS, CALCA, GAST
34vegf437.3GAST, SST, RET, CHGA, IGF2, CALCA
35gnrh437.2SST, CHGA, GHRH, GAST, VIP, INS
36thyroxine43 248.1IGF2, INS, VIP, SST, NTS, CALCA
37dopamine43 28 24 1210.1NTS, GHRH, CALCA, GAST, SST, RET
38adenylate437.1GAST, CALCA, GHRHR, NTS, SST, IAPP
39calcium43 49 24 1210.0CHGA, VIP, POU1F1, GHRHR, IAPP, RET
40glucose437.0INS, CHGA, IAPP, SST, NTS, GHRHR
41estrogen436.9INS, MEN1, GAST, CHGA, VIP, POU1F1
42acth436.9GAST, GHRH, NTS, SST, CHGA, VIP
43octreotide43 59 28 129.8INS, IGF2, VIP, CHGA, SST, GHRH
44tyrosine436.6GAST, RET, POU1F1, INS, IGF2, MEN1
45norepinephrine43 24 128.5IGF2, INS, IAPP, CHGA, VIP, SST
46serine436.5GHRH, GAST, VIP, MEN1, NTS, IAPP
47arginine436.4INS, IGF2, POU1F1, VIP, GHRHR, GHRH
48dexamethasone43 49 28 129.4GAST, GHRHR, GHRH, NTS, SST, IAPP
49glutamate436.3GAST, CALCA, GHRHR, GHRH, NTS, SST
50testosterone43 59 24 129.0VIP, INS, IGF2, CHGA, IAPP, RET

GO Terms for genes affiliated with Pancreatic Islet Cell Tumors

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Cellular components related to Pancreatic Islet Cell Tumors according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1terminal boutonGO:00431959.8CALCA, GHRH
2neuronal cell bodyGO:00430258.6CALCA, SST, IAPP, VIP
3extracellular spaceGO:00056157.5IGF2, INS, IAPP, SST, GHRH, CALCA
4extracellular regionGO:00055766.1GAST, IGF2, INS, VIP, CHGA, IAPP

Biological processes related to Pancreatic Islet Cell Tumors according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1somatotropin secreting cell developmentGO:006013310.2GHRHR, POU1F1
2positive regulation of growth hormone secretionGO:006012410.2GHRH, GHRHR
3growth hormone secretionGO:003025210.2GHRH, GHRHR
4positive regulation of insulin-like growth factor receptor signaling pathwayGO:004356810.1GHRH, GHRHR
5determination of adult lifespanGO:000834010.0GHRHR, POU1F1
6negative regulation of bone resorptionGO:00457799.9CALCA, IAPP
7positive regulation of multicellular organism growthGO:00400189.9GHRHR, GHRH, POU1F1
8cAMP-mediated signalingGO:00199339.9GHRHR, GHRH
9positive regulation of cAMP biosynthetic processGO:00308199.8GHRH, GHRHR, CALCA
10activation of adenylate cyclase activityGO:00071909.8CALCA, GHRHR
11adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.8CALCA, GHRHR, GHRH
12response to painGO:00482659.5RET, CALCA
13positive regulation of insulin receptor signaling pathwayGO:00466289.2INS, IGF2
14positive regulation of vasodilationGO:00459099.2INS, VIP, CALCA
15MAPK cascadeGO:00001659.1INS, RET, MEN1
16positive regulation of glycogen biosynthetic processGO:00457259.1INS, IGF2
17positive regulation of mitosisGO:00458408.7INS, IGF2
18G-protein coupled receptor signaling pathwayGO:00071868.6GAST, SST, VIP, INS
19cell-cell signalingGO:00072678.5INS, IAPP, SST, GHRH, CALCA
20positive regulation of cell proliferationGO:00082848.1GHRHR, GHRH, VIP, POU1F1, INS, IGF2

Molecular functions related to Pancreatic Islet Cell Tumors according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.5NTS, VIP
2insulin-like growth factor receptor bindingGO:00051599.0INS, IGF2
3insulin receptor bindingGO:00051589.0INS, IGF2
4hormone activityGO:00051797.0GAST, IGF2, INS, VIP, IAPP, SST
5protein bindingGO:00055156.3IGF2, INS, VIP, RET, MEN1, NTS

Products for genes affiliated with Pancreatic Islet Cell Tumors

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Sources for Pancreatic Islet Cell Tumors

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3CDC
13ExPASy
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22GTR
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
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46OMIM via Orphanet
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51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet