MCID: PNC053
MIFTS: 43

Pancreatic Islet Cell Tumors malady

Endocrine diseases, Cancer diseases categories

Summaries for Pancreatic Islet Cell Tumors

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues forming... more...

MalaCards: Pancreatic Islet Cell Tumors, also known as islet cell tumor, is related to islet cell tumor and pancreatitis. An important gene associated with Pancreatic Islet Cell Tumors is GHRHR (growth hormone releasing hormone receptor), and among its related pathways are Selected targets of CREB1 and Calcitonin-like ligand receptors. The drug dacarbazine and the compounds forskolin and 111in-pentetreotide have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet and pancreas, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Aliases & Classifications for Pancreatic Islet Cell Tumors

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60UMLS, 42NIH Rare Diseases, 44Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreatic islet cell tumors 42 60
islet cell tumor 44 60
pancreatic endocrine carcinoma 60
islet of langerhans tumor 42
islet cell carcinoma 42
islet cell tumors 42


Related Diseases for Pancreatic Islet Cell Tumors

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17GeneCards, 18GeneDecks
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Diseases related to Pancreatic Islet Cell Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 210)
idRelated DiseaseScoreTop Affiliating Genes
1islet cell tumor31.8SST, GAST
2pancreatitis31.8SST, INS
3diarrhea30.6GAST, SST, VIP, CALCA, CHGA, INS
4hypoglycemia30.6INS, CHGA, IAPP, SST, GAST, IGF2
5pheochromocytoma30.6CALCA, SST, RET, MEN1, NTS, IAPP
6hyperinsulinism30.5SST, INS, IGF2
7acromegaly30.5INS, MEN1, VIP, GHRHR, GHRH, IGF2
8thyroiditis30.5CALCA
9peptic ulcer30.4SST, GAST
10hypokalemia30.4VIP, INS
11adenoma30.4MEN1, GHRHR, GHRH, CHGA, NTS, SST
12gastric ulcer30.3GAST
13zollinger-ellison syndrome30.3GAST, MEN1, GHRH, SST, CHGA
14hypertension30.3CALCA, INS
15duodenal ulcer30.3SST, GAST, INS
16thyroid cancer30.3CALCA, CHGA, SST, RET
17duodenitis30.3GAST
18giant cell tumor30.3CALCA
19sarcoma30.3IGF2
20pancreatic cholera30.3SST, VIP
21tuberous sclerosis30.3TSC1, TSC2
22von hippel-lindau disease30.3MEN1, TSC2, RET
23cholera30.3NTS, VIP, CALCA, INS
24hyperparathyroidism30.3GAST, CALCA, MEN1, CHGA, RET
25gastrinoma30.3IAPP, CHGA, MEN1, GAST, VIP, SST
26somatostatinoma30.3GHRH, GAST, CALCA, VIP, CHGA, SST
27cushing's syndrome30.3GHRH, CHGA, SST, RET, CALCA, MEN1
28insulinoma30.2INS, IGF2, SST, NTS, IAPP, CHGA
29diabetic ketoacidosis30.1INS
30acinar cell carcinoma30.1CHGA, GAST
31cholelithiasis30.1SST
32neuroendocrine tumor30.1VIP, CALCA, GHRH, CHGA, SST
33acute pancreatitis30.1IAPP, SST
34lactic acidosis30.1INS
35neuroendocrine carcinoma30.1MEN1, CALCA, SST, GAST, CHGA
36primary hyperparathyroidism30.1GAST, RET, CHGA, MEN1, CALCA
37obesity30.1IAPP, INS, GHRH, NTS
38hyperglycemia30.1IAPP, INS, SST, GHRH
39diabetes mellitus30.1IAPP, INS, SST, CALCA
40hepatocellular carcinoma30.1MEN1, VIP, INS, IGF2
41vipoma30.1SST, NTS, CHGA, GHRH, MEN1, GAST
42parathyroid carcinoma30.1MEN1, RET
43hypercalcemia30.1CALCA, GAST, MEN1, CHGA, IAPP
44adenocarcinoma30.0IAPP, CHGA, MEN1, GAST, VIP, TSC1
45pancreatic endocrine carcinoma10.7
46pheochromocytoma-islet cell tumor syndrome10.5
47amyloid tumor10.4
48portal hypertension10.2
49gastrointestinal stromal tumor10.2
50mahvash disease10.2

Graphical network of the top 20 diseases related to Pancreatic Islet Cell Tumors:



Diseases related to pancreatic islet cell tumors

Clinical Features for Pancreatic Islet Cell Tumors

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Drugs & Therapeutics for Pancreatic Islet Cell Tumors

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pancreatic Islet Cell Tumors

Drug clinical trials:

Search ClinicalTrials for Pancreatic Islet Cell Tumors

Search NIH Clinical Center for Pancreatic Islet Cell Tumors

Search CenterWatch for Pancreatic Islet Cell Tumors

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pancreatic Islet Cell Tumors

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Anatomical Context for Pancreatic Islet Cell Tumors

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32MalaCards
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MalaCards organs/tissues related to Pancreatic Islet Cell Tumors:

32
Pancreatic islet, Pancreas

Animal Models for Pancreatic Islet Cell Tumors or affiliated genes

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36MGI
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Publications for Pancreatic Islet Cell Tumors

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Genetic Variations for Pancreatic Islet Cell Tumors

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Expression for genes affiliated with Pancreatic Islet Cell Tumors

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Islet Cell Tumors

Search GEO for disease gene expression data for Pancreatic Islet Cell Tumors.

Pathways for genes affiliated with Pancreatic Islet Cell Tumors

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12EMD Millipore, 53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Pancreatic Islet Cell Tumors

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Pancreatic Islet Cell Tumors according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1forskolin44 49 1111.8POU1F1, GHRH, GHRHR, CALCA
2111in-pentetreotide449.4CALCA, CHGA, SST
3mibg449.4CALCA, CHGA, VIP, SST
4clonidine44 28 1111.2GHRH, CALCA, CHGA, NTS, SST
5atropine44 28 1111.2NTS, GAST, GHRH, CALCA
6bromocriptine28 44 1111.1GHRH, SST, VIP, POU1F1, IGF2
7glutamate449.1POU1F1, GAST, GHRHR, GHRH, NTS
8minigastrin449.1SST, GAST, VIP
9lafutidine449.0CALCA, GAST, SST
10catecholamine449.0NTS, IAPP, CHGA, VIP, RET
115-hydroxyindoleacetic acid44 2410.0GAST, VIP, CHGA, SST
12calcium gluconate449.0CALCA, GAST, INS
13gnrh448.9VIP, NTS, CHGA, GAST, GHRH
14naloxone44 49 28 1111.9VIP, GHRH, NTS, SST
15loxiglumide448.8GAST, SST, NTS
16i-app448.8INS, CALCA, GAST, IAPP
17oxyntomodulin44 599.7CHGA, NTS, SST, GAST, VIP
18ribonucleic acid448.7POU1F1, RET, GHRHR, GHRH, IGF2, CHGA
19dopamine44 28 11 2411.7VIP, GAST, GHRH, CHGA, IAPP, NTS
20norepinephrine44 11 2410.6VIP, NTS, CHGA, GHRH, GAST, CALCA
21nifedipine44 49 28 1111.5SST, CHGA, VIP, GAST, GHRH, NTS
22propranolol44 28 49 11 2412.4SST, VIP, CALCA, GAST, GHRH, CHGA
23carbachol44 28 1110.4GAST, NTS, CHGA, VIP, SST
24corticosterone44 59 2410.4VIP, CALCA, GAST, IGF2, NTS
255-hydroxytryptamine448.3CHGA, VIP, SST, NTS, CALCA, GAST
26ibmx44 28 5910.3VIP, IGF2, INS, SST, IAPP, CALCA
27serine448.2TSC2, MEN1, RET, NTS, TSC1, VIP
28dexamethasone44 49 28 1111.1IGF2, INS, NTS, VIP, GHRHR, GHRH
29vitamin d448.1CHGA, POU1F1, CALCA, GAST, MEN1, GHRH
30cyclic amp44 249.1RET, NTS, IAPP, POU1F1, CALCA, VIP
31isoproterenol44 119.1CALCA, VIP, NTS, IAPP, SST, CHGA
32glycogen44 249.0TSC2, CHGA, IAPP, IGF2, INS, TSC1
33acetylcholine44 49 28 11 2412.0NTS, CALCA, VIP, GAST, CHGA, SST
34lactate448.0SST, IGF2, IAPP, INS, CHGA, CALCA
35glucose448.0TSC1, GHRH, IGF2, NTS, IAPP, GAST
36thymidine44 248.9IGF2, MEN1, NTS, VIP, GAST, IAPP
37hydrocortisone44 2 59 1110.8INS, IGF2, SST, GAST, CALCA
38acth447.8IGF2, POU1F1, SST, NTS, CHGA, GHRH
39c-peptide447.7INS, IAPP, NTS, IGF2, SST, CHGA
40histamine44 28 249.6IGF2, SST, VIP, CALCA, GAST, CHGA
41epinephrine44 11 249.5INS, SST, NTS, CHGA, GAST, CALCA
42thyroxine44 248.3CALCA, GAST, GHRH, IGF2, INS, NTS
43octreotide44 59 28 1110.0SST, NTS, CHGA, CALCA, IGF2, INS
44alanine447.0TSC1, INS, VIP, GAST, NTS, RET
45calcium44 49 11 249.9GAST, POU1F1, NTS, CHGA, GHRH, MEN1
46adenylate446.7VIP, IGF2, CHGA, SST, TSC2, NTS
47vegf446.6VIP, SST, GAST, CALCA, MEN1, CHGA
48arginine446.5TSC2, INS, IGF2, SST, NTS, IAPP
49tyrosine446.1RET, TSC1, TSC2, CHGA, MEN1, INS
50testosterone44 59 11 248.8CALCA, GAST, GHRH, CHGA, IAPP, VIP

GO Terms for genes affiliated with Pancreatic Islet Cell Tumors

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16Gene Ontology
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Cellular components related to Pancreatic Islet Cell Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TSC1-TSC2 complexGO:0335969.4TSC2, TSC1
2neuronal cell bodyGO:0430258.5CALCA, IAPP, SST, TSC2, VIP
3extracellular spaceGO:0056158.0GHRH, CALCA, IAPP, SST, INS, IGF2
4extracellular regionGO:0055766.3INS, VIP, CALCA, GAST, GHRH, CHGA

Biological processes related to Pancreatic Islet Cell Tumors according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1somatotropin secreting cell developmentGO:06013310.3POU1F1, GHRHR
2positive regulation of growth hormone secretionGO:06012410.3GHRH, GHRHR
3growth hormone secretionGO:03025210.2GHRHR, GHRH
4positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.1GHRH, GHRHR
5positive regulation of multicellular organism growthGO:04001810.1GHRHR, GHRH, POU1F1
6determination of adult lifespanGO:00834010.1GHRHR, POU1F1
7negative regulation of bone resorptionGO:04577910.0IAPP, CALCA
8positive regulation of cAMP biosynthetic processGO:03081910.0GHRHR, CALCA, GHRH
9adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.9GHRHR, GHRH, CALCA
10negative regulation of cell sizeGO:0457929.9TSC2, TSC1
11negative regulation of TOR signaling cascadeGO:0320079.7TSC1, TSC2
12positive regulation of insulin receptor signaling pathwayGO:0466289.6IGF2, INS
13response to painGO:0482659.5RET, CALCA
14positive regulation of vasodilationGO:0459099.5INS, CALCA, VIP
15positive regulation of glycogen biosynthetic processGO:0457259.3IGF2, INS
16MAPK cascadeGO:0001659.3INS, MEN1, RET
17cell cycle arrestGO:0070509.1TSC2, TSC1, MEN1
18negative regulation of cell proliferationGO:0082859.1SST, MEN1, TSC2, TSC1, POU1F1
19cell-cell signalingGO:0072678.9SST, IAPP, CALCA, GHRH, INS
20insulin receptor signaling pathwayGO:0082868.8IGF2, INS, TSC1, TSC2
21positive regulation of cell proliferationGO:0082848.6POU1F1, VIP, GHRHR, GHRH, IGF2, INS
22G-protein coupled receptor signaling pathwayGO:0071868.4INS, SST, VIP, GAST

Molecular functions related to Pancreatic Islet Cell Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.3IGF2, INS
2hormone activityGO:0051797.0GAST, INS, IGF2, SST, IAPP, CALCA
3protein bindingGO:0055155.4GHRHR, MEN1, GAST, VIP, CALCA, NTS

Products for genes affiliated with Pancreatic Islet Cell Tumors

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Sources for Pancreatic Islet Cell Tumors

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet