MCID: PNC053
MIFTS: 53

Pancreatic Islet Cell Tumors malady

Rare diseases, Endocrine diseases, Cancer diseases categories
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Summaries for Pancreatic Islet Cell Tumors

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65Wikipedia, 33MalaCards
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Wikipedia:65 Pancreatic cancer is when cancer cells develop from the pancreas, a glandular organ located behind the... more...

MalaCards: Pancreatic Islet Cell Tumors, also known as islet cell tumor, is related to islet cell tumor and hypokalemia. An important gene associated with Pancreatic Islet Cell Tumors is GHRHR (growth hormone releasing hormone receptor), and among its related pathways are Regulation of beta-cell development and ADP signalling through P2Y purinoceptor 12. The drug dacarbazine and the compounds mibg and lafutidine have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, pancreas and skin, and related mouse phenotypes are no phenotypic analysis and renal/urinary system.

Aliases & Classifications for Pancreatic Islet Cell Tumors

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62UMLS, 43NIH Rare Diseases, 45Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreatic islet cell tumors 43 62
islet cell tumor 45 62
pancreatic endocrine carcinoma 62
islet of langerhans tumor 43
islet cell carcinoma 43
islet cell tumors 43


Related Diseases for Pancreatic Islet Cell Tumors

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17GeneCards, 18GeneDecks
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Diseases related to Pancreatic Islet Cell Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1islet cell tumor32.0SST, GAST
2hypokalemia30.6INS, VIP
3multiple endocrine neoplasia30.6VIP, CHGA, RET, MEN1, CALCA, GAST
4diarrhea30.6INS, VIP, CHGA, SST, CALCA, GAST
5hyperinsulinism30.6SST, INS, IGF2
6duodenitis30.6GAST
7pheochromocytoma30.5VIP, CHGA, CALCA, NTS, MEN1, SST
8hypoglycemia30.5IGF2, INS, CHGA, IAPP, SST, GHRH
9von hippel-lindau disease30.5MEN1, RET
10cushing's syndrome30.4GHRH, SST, INS
11hypercalcemia30.4CHGA, IAPP, MEN1, CALCA, GAST
12zollinger-ellison syndrome30.4CHGA, SST, GAST, GHRH, MEN1
13acromegaly30.4GHRHR, GHRH, MEN1, SST, VIP, INS
14cholera30.4INS, VIP, NTS, CALCA
15acinar cell carcinoma30.3CHGA, GAST
16hyperparathyroidism30.3CHGA, RET, MEN1, CALCA, GAST
17pancreatic cholera30.3VIP, SST
18glucagonoma30.3GAST, GHRH, MEN1, SST, CHGA, VIP
19gastrinoma30.3VIP, CHGA, IAPP, SST, MEN1, GAST
20somatostatinoma30.3GAST, CALCA, GHRH, SST, CHGA, VIP
21type 2 diabetes mellitus30.2NTS, IAPP, INS
22obesity30.2INS, IAPP, NTS, GHRH
23duodenal ulcer30.2INS, SST, GAST
24hyperglycemia30.2INS, IAPP, SST, GHRH
25neuroendocrine tumor30.1VIP, CHGA, SST, GHRH, CALCA
26diabetes mellitus30.1CALCA, SST, IAPP, INS
27thyroid cancer30.1CALCA, SST, RET, CHGA
28neuroendocrine carcinoma30.1CHGA, SST, MEN1, CALCA, GAST
29primary hyperparathyroidism30.1CHGA, RET, MEN1, CALCA, GAST
30hepatocellular carcinoma30.1MEN1, VIP, INS, IGF2
31vipoma30.1GAST, GHRH, NTS, MEN1, SST, CHGA
32adenocarcinoma30.0POU1F1, VIP, CHGA, IAPP, SST, MEN1
33adenoma30.0GAST, CALCA, GHRHR, GHRH, NTS, MEN1
34insulinoma29.9GAST, CALCA, INS, VIP, CHGA, IAPP
35pancreatitis11.2
36pheochromocytoma-islet cell tumor syndrome10.5
37thyroiditis10.4
38solitary fibrous tumor10.4
39portal hypertension10.3
40gastrointestinal stromal tumor10.3
41hypertension10.3
42mahvash disease10.3
43tuberous sclerosis10.3
44hepatitis10.3
45sarcoma10.3
46somatostatin analog10.3
47diabetic ketoacidosis10.1
48pancreatic endocrine carcinoma10.1
49hyperthyroxinemia10.1
50dermatitis10.1

Graphical network of the top 20 diseases related to Pancreatic Islet Cell Tumors:



Diseases related to pancreatic islet cell tumors

Symptoms for Pancreatic Islet Cell Tumors

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Drugs & Therapeutics for Pancreatic Islet Cell Tumors

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pancreatic Islet Cell Tumors

Search NIH Clinical Center for Pancreatic Islet Cell Tumors

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Pancreatic Islet Cell Tumors

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Anatomical Context for Pancreatic Islet Cell Tumors

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33MalaCards
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MalaCards organs/tissues related to Pancreatic Islet Cell Tumors:

33
Pancreatic islet, Pancreas, Skin, Liver, Pituitary, Testes

Animal Models for Pancreatic Islet Cell Tumors or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pancreatic Islet Cell Tumors:

37 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030127.8NTS, SST, RET, INS, IGF2
2MP:00053677.5IGF2, INS, CHGA, RET, CALCA
3MP:00053817.3IGF2, INS, RET, SST, MEN1, GAST
4MP:00053857.0IGF2, INS, VIP, CHGA, RET, MEN1
5MP:00053866.9IGF2, INS, VIP, RET, SST, NTS
6MP:00053896.9IGF2, INS, POU1F1, VIP, CHGA, RET
7MP:00036316.4IGF2, INS, POU1F1, RET, SST, MEN1
8MP:00053796.4IGF2, INS, POU1F1, VIP, CHGA, RET
9MP:00107686.3IGF2, INS, POU1F1, VIP, CHGA, RET
10MP:00053786.2CHGA, POU1F1, INS, IGF2, IAPP, RET
11MP:00053876.0VIP, POU1F1, INS, IGF2, IAPP, RET
12MP:00053765.0GAST, IGF2, INS, POU1F1, VIP, CHGA

Publications for Pancreatic Islet Cell Tumors

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52PubMed
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Articles related to Pancreatic Islet Cell Tumors:

(show top 50)    (show all 91)
idTitleAuthorsYear
1
Pancreatic islet cell tumor secreting insulin-like growth factor type-II in a dog. (19780935)
2009
2
Spontaneous pancreatic islet cell tumor in a black and white colobus monkey (Colobus guereza kikuyuensis). (18269522)
2008
3
Multi-detector row CT of pancreatic islet cell tumors. (16549609)
2006
4
Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989-1999). (12322919)
2002
5
High frequency loss of heterozygosity in von Hippel-Lindau (VHL)-associated and sporadic pancreatic islet cell tumors: evidence for a stepwise mechanism for malignant conversion in VHL tumorigenesis. (11929809)
2002
6
Induction of pancreatic islet cell tumors in rats by repeated intravenous administration of 4-hydroxyaminoquinoline 1-oxide. (11442018)
2001
7
Evaluation of pancreatic islet cell tumors by fluorine-18 fluorodeoxyglucose positron emission tomography: comparison with other modalities. (10656646)
2000
8
Functional pancreatic islet cell tumors with liver metastasis: the role of cytoreductive surgery and transcatheter arterial chemoembolization: a report of five cases. (9884450)
1998
9
Surgical decision-making affected by clinical and genetic screening of a novel kindred with von Hippel-Lindau disease and pancreatic islet cell tumors. (9488521)
1998
10
Immunohistochemistry of pancreatic islet cell tumors in the ferret (Mustela putorius furo). (9381649)
1997
11
Pancreatic islet cell tumor producing vasoactive intestinal polypeptide and calcitonin. (9494586)
1997
12
A growth hormone-releasing hormone-producing pancreatic islet cell tumor metastasized to the pituitary is associated with pituitary somatotroph hyperplasia and acromegaly. (9253362)
1997
13
Chromogranin A plasma concentration and expression in pancreatic islet cell tumors of dogs and cats. (9185968)
1997
14
Absence of RET proto-oncogene mutations in a father and son with pheochromocytoma and pancreatic islet cell tumor. (9179691)
1997
15
The concurrence of duodenal epithelioid stromal sarcoma, pulmonary chondromatous hamartoma, and nonfunctioning pancreatic islet cell tumor. A possible analogue of Carney's triad? (8060238)
1994
16
Surgical experience with pancreatic islet-cell tumors. (8105769)
1993
17
Islet amyloid polypeptide-producing pancreatic islet cell tumor. A clinical and biochemical characterization. (1326785)
1992
18
Pancreatic islet cell tumors metastatic to the liver: treatment by hepatic artery chemo-embolization. (2559021)
1989
19
Hyperinsulinism and hypoglycemia associated with pancreatic islet cell tumor in a ferret. (2537277)
1989
20
Use of long-acting somatostatin analog SMS 201-995 in patients with pancreatic islet cell tumors. (2537716)
1989
21
Endoscopic retrograde cholangiopancreatography in pancreatic islet cell tumors. (2832244)
1988
22
Pancreatic islet cell tumors. (3029883)
1987
23
Radiotherapy in the management of pancreatic islet cell tumors. (3040209)
1987
24
Thyrotropin-releasing hormone and insulin in chemically induced pancreatic islet cell tumors in rats. (3023223)
1986
25
Acromegaly due to secretion of growth hormone by an ectopic pancreatic islet-cell tumor. (2981107)
1985
26
Serum levels of alpha-1-antitrypsin in pancreatic islet cell tumors. (6098624)
1984
27
Computed tomography and nuclear magnetic resonance imaging of pancreatic islet cell tumors. (6316575)
1983
28
Metastasizing pancreatic islet cell tumors in the rat. (6279704)
1982
29
Ultrasonic demonstration of small pancreatic islet cell tumors. (6282939)
1982
30
Selective growth hormone and cyclic AMP stimulating activity is present in human pancreatic islet cell tumor. (6123522)
1982
31
Ultrasonic investigation of pancreatic islet cell tumors. (6302303)
1982
32
Commercial immunoperoxidase kits in the study of 13 pancreatic islet-cell tumors. (6126116)
1982
33
Rupture of a giant non-functioning pancreatic islet cell tumor following minimal trauma. (6258461)
1981
34
Calcium stimulation test in the evaluation of insulin secreting pancreatic islet cell tumors: case reports. (6259559)
1981
35
Pancreatic islet cell tumors found in rats given alloxan and nicotinamide. (6254753)
1980
36
Pancreatic islet cell tumors:insulinoma, gastrinoma, and glucagonoma. (220743)
1979
37
Coexistence of bilateral pheochromocytoma and pancreatic islet cell tumor: report of a case and review of the literature. (215301)
1978
38
Endocrine surgery. Pancreatic islet cell tumor presenting as hyperparathyroidism. (206637)
1978
39
Pheochromocytoma with prominent calcification and associated pancreatic islet cell tumor. (199750)
1977
40
Pancreatic islet cell tumors: a brief review. (183636)
1976
41
Pancreatic islet cell tumors in domestic animals. Data from 11 colleges of veterinary medicine in the United States and Canada. (4365909)
1974
42
Hormone-producing pancreatic islet-cell tumors and hyperplasia. (4345017)
1972
43
Plasma proinsulin in patients with functioning pancreatic islet cell tumors. (4342038)
1972
44
Endocrine syndromes associated with pancreatic islet cell tumors. (4298136)
1968
45
DIARRHEA ASSOCIATED WITH PANCREATIC ISLET-CELL TUMORS. (14116905)
1964
46
PANCREATIC ISLET CELL TUMOR IN A DOG. (14238882)
1964
47
Effects of extracts of primary and metastatic pancreatic islet cell tumors on gastric secretion. (13952167)
1963
48
Pancreatic islet cell tumors and renal tumors in the male rat following neutron exposure. (14493916)
1962
49
Pancreatic islet cell tumors and renal tumors in the male rat following neutron exposure. (14038763)
1961
50
Clinics on endocrine and metabolic diseases. 3. Hyperinsulinism: review of 95 cases of functioning pancreatic islet cell tumors. (13748469)
1960

Variations for Pancreatic Islet Cell Tumors

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Expression for genes affiliated with Pancreatic Islet Cell Tumors

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Islet Cell Tumors

Search GEO for disease gene expression data for Pancreatic Islet Cell Tumors.

Pathways for genes affiliated with Pancreatic Islet Cell Tumors

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Sources:
50PathCards, 55Reactome, 30KEGG, 60Thomson Reuters, 53QIAGEN, 51PharmGKB, 12EMD Millipore, 38NCBI BioSystems Database
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Pathways related to Pancreatic Islet Cell Tumors according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4IAPP, INS
2
Show member pathways
9.2IAPP, GHRH, GHRHR, CALCA
39.0IAPP, CHGA, INS
48.9VIP, IAPP, GHRH, GHRHR, CALCA
5
Show member pathways
8.5IAPP, SST, NTS, GHRH, GHRHR, CALCA
6
Show member pathways
5.9GAST, IGF2, INS, VIP, IAPP, SST

Compounds for genes affiliated with Pancreatic Islet Cell Tumors

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45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Pancreatic Islet Cell Tumors according to GeneCards/GeneDecks:

(show top 50)    (show all 167)
idCompoundScoreTop Affiliating Genes
1mibg459.2CALCA, SST, CHGA, VIP
2lafutidine459.2CALCA, GAST, SST
3minigastrin459.2GAST, SST, VIP
4loxiglumide459.1SST, NTS, GAST
5naloxone45 29 51 1112.1SST, VIP, NTS, GHRH
65-hydroxyindoleacetic acid45 2410.1VIP, GAST, CHGA, SST
7clonidine45 51 29 1112.0GHRH, NTS, CALCA, SST, CHGA
8111in-pentetreotide459.0SST, CALCA, CHGA
9calcium gluconate458.9INS, GAST, CALCA
10oxyntomodulin45 619.9NTS, GAST, SST, CHGA, VIP
11catecholamine458.9NTS, RET, IAPP, VIP, CHGA
12bromocriptine45 29 1110.8SST, GHRH, VIP, POU1F1, IGF2
13i-app458.8GAST, CALCA, IAPP, INS
14carbachol45 29 1110.7SST, GAST, NTS, CHGA, VIP
15nifedipine45 29 51 1111.6VIP, GAST, GHRH, NTS, SST, CHGA
16atropine45 29 1110.6GAST, VIP, SST, GHRH, NTS, CALCA
17corticosterone45 61 2410.5IGF2, VIP, GAST, CALCA, NTS
18propranolol45 29 51 24 1112.5VIP, SST, GHRH, CALCA, GAST, CHGA
195-hydroxytryptamine458.5GAST, CALCA, NTS, SST, CHGA, VIP
20ribonucleic acid458.4GHRH, CHGA, POU1F1, IGF2, RET, GHRHR
21isoproterenol45 119.2SST, CALCA, NTS, GAST, CHGA, VIP
22acetylcholine45 51 29 24 1112.2GAST, VIP, CHGA, IAPP, SST, NTS
23vitamin d458.1GHRH, IGF2, POU1F1, CALCA, GAST, CHGA
24thymidine45 249.1IGF2, VIP, IAPP, MEN1, NTS, GAST
25ibmx45 61 299.9CALCA, SST, IAPP, VIP, INS, IGF2
26hydrocortisone45 3 61 1110.8CALCA, GAST, INS, SST, IGF2
27cyclic amp45 248.8POU1F1, VIP, CHGA, IAPP, RET, NTS
28pge2457.8GAST, CALCA, SST, VIP, IGF2, NTS
29forskolin45 51 119.7NTS, CALCA, GHRHR, GHRH, IGF2, VIP
30histamine45 29 249.6IAPP, IGF2, SST, VIP, NTS, CALCA
31c-peptide457.6GAST, NTS, IGF2, INS, CHGA, IAPP
32lactate457.4SST, CALCA, IAPP, CHGA, IGF2, INS
33epinephrine45 24 119.4CHGA, IAPP, SST, NTS, CALCA, GAST
34vegf457.3GAST, SST, RET, CHGA, IGF2, CALCA
35gnrh457.2SST, CHGA, GHRH, GAST, VIP, INS
36thyroxine45 248.1IGF2, INS, VIP, SST, NTS, CALCA
37dopamine45 29 24 1110.1NTS, GHRH, CALCA, GAST, SST, RET
38adenylate457.1GAST, CALCA, GHRHR, NTS, SST, IAPP
39calcium45 51 24 1110.0CHGA, VIP, POU1F1, GHRHR, IAPP, RET
40glucose457.0INS, CHGA, IAPP, SST, NTS, GHRHR
41estrogen456.9INS, MEN1, GAST, CHGA, VIP, POU1F1
42acth456.9GAST, GHRH, NTS, SST, CHGA, VIP
43octreotide45 61 29 119.8INS, IGF2, VIP, CHGA, SST, GHRH
44tyrosine456.6GAST, RET, POU1F1, INS, IGF2, MEN1
45norepinephrine45 24 118.5IGF2, INS, IAPP, CHGA, VIP, SST
46serine456.5GHRH, GAST, VIP, MEN1, NTS, IAPP
47arginine456.4INS, IGF2, POU1F1, VIP, GHRHR, GHRH
48dexamethasone45 51 29 119.4GAST, GHRHR, GHRH, NTS, SST, IAPP
49glutamate456.3GAST, CALCA, GHRHR, GHRH, NTS, SST
50testosterone45 61 24 119.0VIP, INS, IGF2, CHGA, IAPP, RET

GO Terms for genes affiliated with Pancreatic Islet Cell Tumors

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16Gene Ontology
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Cellular components related to Pancreatic Islet Cell Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1terminal boutonGO:0431959.8CALCA, GHRH
2neuronal cell bodyGO:0430258.6CALCA, SST, IAPP, VIP
3extracellular spaceGO:0056157.5IGF2, INS, IAPP, SST, GHRH, CALCA
4extracellular regionGO:0055766.1GAST, IGF2, INS, VIP, CHGA, IAPP

Biological processes related to Pancreatic Islet Cell Tumors according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1somatotropin secreting cell developmentGO:06013310.2GHRHR, POU1F1
2positive regulation of growth hormone secretionGO:06012410.2GHRH, GHRHR
3growth hormone secretionGO:03025210.2GHRH, GHRHR
4positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.1GHRH, GHRHR
5determination of adult lifespanGO:00834010.0GHRHR, POU1F1
6negative regulation of bone resorptionGO:0457799.9CALCA, IAPP
7positive regulation of multicellular organism growthGO:0400189.9GHRHR, GHRH, POU1F1
8cAMP-mediated signalingGO:0199339.9GHRHR, GHRH
9positive regulation of cAMP biosynthetic processGO:0308199.8GHRH, GHRHR, CALCA
10activation of adenylate cyclase activityGO:0071909.8CALCA, GHRHR
11adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.8CALCA, GHRHR, GHRH
12response to painGO:0482659.5RET, CALCA
13positive regulation of insulin receptor signaling pathwayGO:0466289.2INS, IGF2
14positive regulation of vasodilationGO:0459099.2INS, VIP, CALCA
15MAPK cascadeGO:0001659.1INS, RET, MEN1
16positive regulation of glycogen biosynthetic processGO:0457259.1INS, IGF2
17positive regulation of mitosisGO:0458408.7INS, IGF2
18G-protein coupled receptor signaling pathwayGO:0071868.6GAST, SST, VIP, INS
19cell-cell signalingGO:0072678.5INS, IAPP, SST, GHRH, CALCA
20positive regulation of cell proliferationGO:0082848.1GHRHR, GHRH, VIP, POU1F1, INS, IGF2

Molecular functions related to Pancreatic Islet Cell Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.5NTS, VIP
2insulin-like growth factor receptor bindingGO:0051599.0INS, IGF2
3insulin receptor bindingGO:0051589.0INS, IGF2
4hormone activityGO:0051797.0GAST, IGF2, INS, VIP, IAPP, SST
5protein bindingGO:0055156.3IGF2, INS, VIP, RET, MEN1, NTS

Products for genes affiliated with Pancreatic Islet Cell Tumors

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Sources for Pancreatic Islet Cell Tumors

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet