MCID: PNC053
MIFTS: 47

Pancreatic Islet Cell Tumors malady

Endocrine, Cancer categories

Summaries for Pancreatic Islet Cell Tumors

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64Wikipedia, 33MalaCards
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Wikipedia:64 Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues forming... more...

MalaCards: Pancreatic Islet Cell Tumors, also known as islet cell tumor, is related to multiple endocrine neoplasia and hypoglycemia. An important gene associated with Pancreatic Islet Cell Tumors is GHRHR (growth hormone releasing hormone receptor), and among its related pathways are Selected targets of CREB1 and Calcitonin-like ligand receptors. The drug dacarbazine and the compounds forskolin and 111in-pentetreotide have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and b cells, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Aliases & Classifications for Pancreatic Islet Cell Tumors

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Endocrine


Aliases & Descriptions:

pancreatic islet cell tumors 43 61
islet cell tumor 45 61
pancreatic endocrine carcinoma 61
islet of langerhans tumor 43
islet cell carcinoma 43
islet cell tumors 43


Related Diseases for Pancreatic Islet Cell Tumors

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pancreatic Islet Cell Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1multiple endocrine neoplasia30.8RET, CHGA, MEN1, GAST, CALCA, VIP
2hypoglycemia30.6INS, CHGA, IAPP, SST, GAST, IGF2
3pheochromocytoma30.6CALCA, SST, RET, MEN1, NTS, IAPP
4hyperinsulinism30.5SST, INS, IGF2
5acromegaly30.5INS, MEN1, VIP, GHRHR, GHRH, IGF2
6adenoma30.5MEN1, GHRHR, GHRH, CHGA, NTS, SST
7gastric ulcer30.5GAST
8hypokalemia30.5VIP, INS
9zollinger-ellison syndrome30.3GAST, MEN1, GHRH, SST, CHGA
10hypercalcemia30.3CALCA, GAST, MEN1, CHGA, IAPP
11duodenal ulcer30.3SST, GAST, INS
12thyroid cancer30.3CALCA, CHGA, SST, RET
13pancreatic cholera30.3SST, VIP
14tuberous sclerosis30.3TSC1, TSC2
15serotonin syndrome30.3GAST, CHGA, MEN1, GHRH, SST
16cholera30.3NTS, VIP, CALCA, INS
17glucagonoma30.3MEN1, GAST, VIP, SST, CHGA, GHRH
18gastrinoma30.3IAPP, CHGA, MEN1, GAST, VIP, SST
19somatostatinoma30.3GHRH, GAST, CALCA, VIP, CHGA, SST
20cushing's syndrome30.3GHRH, CHGA, SST, RET, CALCA, MEN1
21insulinoma30.3INS, IGF2, SST, NTS, IAPP, CHGA
22diabetic ketoacidosis30.1INS
23acinar cell carcinoma30.1CHGA, GAST
24pancreatic endocrine carcinoma30.1SST, GAST
25parathyroid carcinoma30.1MEN1, RET
26cholelithiasis30.1SST
27neuroendocrine carcinoma30.1MEN1, CALCA, SST, GAST, CHGA
28acute pancreatitis30.1IAPP, SST
29primary hyperparathyroidism30.1GAST, RET, CHGA, MEN1, CALCA
30pituitary tumors30.1VIP, MEN1, GHRHR, GHRH, CHGA, SST
31vipoma30.1SST, NTS, CHGA, GHRH, MEN1, GAST
32adenocarcinoma30.1IAPP, CHGA, MEN1, GAST, VIP, TSC1
33carcinoid syndrome30.1SST, NTS, CHGA, GHRH, MEN1, GAST
34pheochromocytoma-islet cell tumor syndrome10.5
35pancreatic endocrine tumors10.5
36amyloid tumor10.4
37solitary fibrous tumor10.3
38portal hypertension10.3
39gastrointestinal stromal tumor10.3
40mahvash disease10.3
41pancreatic somatostatinoma10.2
42pancreatic gastrinoma10.2
43carney triad10.2
44functioning pancreatic endocrine tumor10.2
45somatostatin analog10.2
46ductal carcinoma in situ10.1
47hyperthyroxinemia10.1
48adenocarcinoma in situ10.1
49chylous ascites10.1
50cystadenoma10.1

Graphical network of the top 20 diseases related to Pancreatic Islet Cell Tumors:



Diseases related to pancreatic islet cell tumors

Clinical Features for Pancreatic Islet Cell Tumors

Drugs & Therapeutics for Pancreatic Islet Cell Tumors

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Pancreatic Islet Cell Tumors

Drug clinical trials:

Search ClinicalTrials for Pancreatic Islet Cell Tumors

Search NIH Clinical Center for Pancreatic Islet Cell Tumors

Search CenterWatch for Pancreatic Islet Cell Tumors

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Pancreatic Islet Cell Tumors

Anatomical Context for Pancreatic Islet Cell Tumors

Sources:
33MalaCards
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MalaCards organs/tissues related to Pancreatic Islet Cell Tumors:

33
Liver, Pancreas, B cells, Pancreatic islet

Animal Models for Pancreatic Islet Cell Tumors or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Pancreatic Islet Cell Tumors

Sources:
51PubMed
See all sources

Articles related to Pancreatic Islet Cell Tumors:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function. (22883930)
2013
2
In vivo molecular imaging of somatostatin receptors in pancreatic islet cells and neuroendocrine tumors by miniaturized confocal laser-scanning fluorescence microscopy. (20233796)
2010
3
Diffusion weighted MR imaging of pancreatic islet cell tumors. (19264435)
2010
4
Systematic comparison of sporadic and syndromic pancreatic islet cell tumors. (20660572)
2010
5
KIT is an independent prognostic marker for pancreatic endocrine tumors: a finding derived from analysis of islet cell differentiation markers. (19574886)
2009
6
Multi-detector row CT of pancreatic islet cell tumors. (16549609)
2006
7
Extensive acrochordons and pancreatic islet-cell tumors in tuberous sclerosis associated with TSC2 mutations. (16835931)
2006
8
Surgical treatment of non-functioning pancreatic islet cell tumors. (15719379)
2005
9
Non-islet origin of pancreatic islet cell tumors. (15070966)
2004
10
Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989-1999). (12322919)
2002
11
High frequency loss of heterozygosity in von Hippel-Lindau (VHL)-associated and sporadic pancreatic islet cell tumors: evidence for a stepwise mechanism for malignant conversion in VHL tumorigenesis. (11929809)
2002
12
New markers for pancreatic islets and islet cell tumors. (12167099)
2002
13
Induction of pancreatic islet cell tumors in rats by repeated intravenous administration of 4-hydroxyaminoquinoline 1-oxide. (11442018)
2001
14
Ultrasound-guided laparoscopic resection of pancreatic islet cell tumors. (10872980)
2000
15
Pancreatitis associated with pancreatic islet cell tumors. (10414710)
1999
16
Functional pancreatic islet cell tumors with liver metastasis: the role of cytoreductive surgery and transcatheter arterial chemoembolization: a report of five cases. (9884450)
1998
17
Surgical decision-making affected by clinical and genetic screening of a novel kindred with von Hippel-Lindau disease and pancreatic islet cell tumors. (9488521)
1998
18
Immunohistochemistry of pancreatic islet cell tumors in the ferret (Mustela putorius furo). (9381649)
1997
19
Pancreatic polypeptide is a useful plasma marker for radiographically evident pancreatic islet cell tumors in patients with multiple endocrine neoplasia type 1. (9426414)
1997
20
Gelatinases and inhibitors of gelatinases in pancreatic islets and islet cell tumors. (9021726)
1997
21
Diagnosis and treatment of insulin-secreting pancreatic islet cell tumors in ferrets: 57 cases (1986-1994). (8921033)
1996
22
Surgical experience with pancreatic islet-cell tumors. (8105769)
1993
23
Comparison of plasma pancreastatin and GAWK concentrations, presumed processing products of chromogranin A and B, in plasma of patients with pancreatic islet cell tumors. (8288164)
1993
24
Pancreatic islet cell tumors metastatic to the liver: treatment by hepatic artery chemo-embolization. (2559021)
1989
25
Use of long-acting somatostatin analog SMS 201-995 in patients with pancreatic islet cell tumors. (2537716)
1989
26
The role of morphometry in predicting prognosis in pancreatic islet cell tumors. (2544252)
1989
27
Pancreatic islet cell tumors. (3029883)
1987
28
Radiotherapy in the management of pancreatic islet cell tumors. (3040209)
1987
29
Thyrotropin-releasing hormone and insulin in chemically induced pancreatic islet cell tumors in rats. (3023223)
1986
30
CT of pancreatic islet cell tumors. (6318260)
1984
31
Computed tomography and nuclear magnetic resonance imaging of pancreatic islet cell tumors. (6316575)
1983
32
Ultrasonic demonstration of small pancreatic islet cell tumors. (6282939)
1982
33
Ultrasonic investigation of pancreatic islet cell tumors. (6302303)
1982
34
Commercial immunoperoxidase kits in the study of 13 pancreatic islet-cell tumors. (6126116)
1982
35
Calcium stimulation test in the evaluation of insulin secreting pancreatic islet cell tumors: case reports. (6259559)
1981
36
Pancreatic islet cell tumors found in rats given alloxan and nicotinamide. (6254753)
1980
37
Computed tomographic detection of nonbeta pancreatic islet cell tumors. (6244605)
1980
38
Pancreatic islet cell tumors:insulinoma, gastrinoma, and glucagonoma. (220743)
1979
39
Crystal-like deposits of amyloid in pancreatic islet cell tumors. (222228)
1979
40
Pancreatic islet cell tumors in domestic animals. Data from 11 colleges of veterinary medicine in the United States and Canada. (4365909)
1974
41
Plasma proinsulin in patients with functioning pancreatic islet cell tumors. (4342038)
1972
42
Endocrine syndromes associated with pancreatic islet cell tumors. (4298136)
1968
43
PANCREATIC ISLET CELL TUMORS: REPORT OF SIX CASES. (14301307)
1965
44
DIARRHEA ASSOCIATED WITH PANCREATIC ISLET-CELL TUMORS. (14116905)
1964
45
Effects of extracts of primary and metastatic pancreatic islet cell tumors on gastric secretion. (13952167)
1963
46
Functioning pancreatic islet cell tumors studied electron microscopically. (13967310)
1963
47
Pancreatic islet cell tumors and renal tumors in the male rat following neutron exposure. (14493916)
1962
48
Pancreatic islet cell tumors and renal tumors in the male rat following neutron exposure. (14038763)
1961
49
Clinics on endocrine and metabolic diseases. 3. Hyperinsulinism: review of 95 cases of functioning pancreatic islet cell tumors. (13748469)
1960
50
Hypoglycemia associated with pancreatic islet cell tumors. Review of the literature and case report of a malignant tumor. (14399620)
1960

Genetic Variations for Pancreatic Islet Cell Tumors

Expression for genes affiliated with Pancreatic Islet Cell Tumors

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pancreatic Islet Cell Tumors

Search GEO for disease gene expression data for Pancreatic Islet Cell Tumors.

Pathways for genes affiliated with Pancreatic Islet Cell Tumors

Sources:
12EMD Millipore, 54Reactome, 52QIAGEN, 30KEGG
See all sources

Compounds for genes affiliated with Pancreatic Islet Cell Tumors

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Pancreatic Islet Cell Tumors according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1forskolin45 50 1111.8POU1F1, GHRH, GHRHR, CALCA
2111in-pentetreotide459.4CALCA, CHGA, SST
3mibg459.4CALCA, CHGA, VIP, SST
4clonidine45 29 1111.2GHRH, CALCA, CHGA, NTS, SST
5atropine45 29 1111.2NTS, GAST, GHRH, CALCA
6bromocriptine29 45 1111.1GHRH, SST, VIP, POU1F1, IGF2
7glutamate459.1POU1F1, GAST, GHRHR, GHRH, NTS
8minigastrin459.1SST, GAST, VIP
9lafutidine459.0CALCA, GAST, SST
10catecholamine459.0NTS, IAPP, CHGA, VIP, RET
115-hydroxyindoleacetic acid45 2410.0GAST, VIP, CHGA, SST
12calcium gluconate459.0CALCA, GAST, INS
13gnrh458.9VIP, NTS, CHGA, GAST, GHRH
14naloxone45 50 29 1111.9VIP, GHRH, NTS, SST
15loxiglumide458.8GAST, SST, NTS
16i-app458.8INS, CALCA, GAST, IAPP
17oxyntomodulin45 609.7CHGA, NTS, SST, GAST, VIP
18ribonucleic acid458.7POU1F1, RET, GHRHR, GHRH, IGF2, CHGA
19dopamine45 29 11 2411.7VIP, GAST, GHRH, CHGA, IAPP, NTS
20norepinephrine45 11 2410.6VIP, NTS, CHGA, GHRH, GAST, CALCA
21nifedipine45 50 29 1111.5SST, CHGA, VIP, GAST, GHRH, NTS
22propranolol45 29 50 11 2412.4SST, VIP, CALCA, GAST, GHRH, CHGA
23carbachol45 29 1110.4GAST, NTS, CHGA, VIP, SST
24corticosterone45 60 2410.4VIP, CALCA, GAST, IGF2, NTS
255-hydroxytryptamine458.3CHGA, VIP, SST, NTS, CALCA, GAST
26ibmx45 29 6010.3VIP, IGF2, INS, SST, IAPP, CALCA
27serine458.2TSC2, MEN1, RET, NTS, TSC1, VIP
28dexamethasone45 50 29 1111.1IGF2, INS, NTS, VIP, GHRHR, GHRH
29vitamin d458.1CHGA, POU1F1, CALCA, GAST, MEN1, GHRH
30cyclic amp45 249.1RET, NTS, IAPP, POU1F1, CALCA, VIP
31isoproterenol45 119.1CALCA, VIP, NTS, IAPP, SST, CHGA
32glycogen45 249.0TSC2, CHGA, IAPP, IGF2, INS, TSC1
33acetylcholine45 50 29 11 2412.0NTS, CALCA, VIP, GAST, CHGA, SST
34lactate458.0SST, IGF2, IAPP, INS, CHGA, CALCA
35glucose458.0TSC1, GHRH, IGF2, NTS, IAPP, GAST
36thymidine45 248.9IGF2, MEN1, NTS, VIP, GAST, IAPP
37hydrocortisone45 2 60 1110.8INS, IGF2, SST, GAST, CALCA
38acth457.8IGF2, POU1F1, SST, NTS, CHGA, GHRH
39c-peptide457.7INS, IAPP, NTS, IGF2, SST, CHGA
40histamine45 29 249.6IGF2, SST, VIP, CALCA, GAST, CHGA
41epinephrine45 11 249.5INS, SST, NTS, CHGA, GAST, CALCA
42thyroxine45 248.3CALCA, GAST, GHRH, IGF2, INS, NTS
43octreotide45 60 29 1110.0SST, NTS, CHGA, CALCA, IGF2, INS
44alanine457.0TSC1, INS, VIP, GAST, NTS, RET
45calcium45 50 11 249.9GAST, POU1F1, NTS, CHGA, GHRH, MEN1
46adenylate456.7VIP, IGF2, CHGA, SST, TSC2, NTS
47vegf456.6VIP, SST, GAST, CALCA, MEN1, CHGA
48arginine456.5TSC2, INS, IGF2, SST, NTS, IAPP
49tyrosine456.1RET, TSC1, TSC2, CHGA, MEN1, INS
50testosterone45 60 11 248.8CALCA, GAST, GHRH, CHGA, IAPP, VIP

GO Terms for genes affiliated with Pancreatic Islet Cell Tumors

Sources:
16Gene Ontology
See all sources

Cellular components related to Pancreatic Islet Cell Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TSC1-TSC2 complexGO:0335969.4TSC2, TSC1
2neuronal cell bodyGO:0430258.5CALCA, IAPP, SST, TSC2, VIP
3extracellular spaceGO:0056158.0GHRH, CALCA, IAPP, SST, INS, IGF2
4extracellular regionGO:0055766.3INS, VIP, CALCA, GAST, GHRH, CHGA

Biological processes related to Pancreatic Islet Cell Tumors according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1somatotropin secreting cell developmentGO:06013310.3POU1F1, GHRHR
2positive regulation of growth hormone secretionGO:06012410.3GHRHR, GHRH
3growth hormone secretionGO:03025210.2GHRHR, GHRH
4determination of adult lifespanGO:00834010.1POU1F1, GHRHR
5positive regulation of multicellular organism growthGO:04001810.1GHRHR, GHRH, POU1F1
6positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.1GHRH, GHRHR
7negative regulation of bone resorptionGO:04577910.0IAPP, CALCA
8positive regulation of cAMP biosynthetic processGO:03081910.0GHRH, GHRHR, CALCA
9adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.9GHRH, GHRHR, CALCA
10negative regulation of cell sizeGO:0457929.9TSC2, TSC1
11negative regulation of TOR signaling cascadeGO:0320079.7TSC2, TSC1
12positive regulation of insulin receptor signaling pathwayGO:0466289.6INS, IGF2
13response to painGO:0482659.5RET, CALCA
14positive regulation of vasodilationGO:0459099.5INS, CALCA, VIP
15positive regulation of glycogen biosynthetic processGO:0457259.3IGF2, INS
16MAPK cascadeGO:0001659.3INS, RET, MEN1
17cell cycle arrestGO:0070509.1TSC2, TSC1, MEN1
18negative regulation of cell proliferationGO:0082859.1MEN1, SST, POU1F1, TSC1, TSC2
19cell-cell signalingGO:0072678.9CALCA, GHRH, IAPP, SST, INS
20insulin receptor signaling pathwayGO:0082868.8IGF2, INS, TSC1, TSC2
21positive regulation of cell proliferationGO:0082848.6INS, POU1F1, IGF2, GHRH, GHRHR, VIP
22G-protein coupled receptor signaling pathwayGO:0071868.4VIP, GAST, SST, INS

Molecular functions related to Pancreatic Islet Cell Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.3INS, IGF2
2hormone activityGO:0051797.0INS, VIP, CALCA, GAST, IAPP, SST
3protein bindingGO:0055155.4VIP, CALCA, GAST, MEN1, GHRHR, NTS

Products for genes affiliated with Pancreatic Islet Cell Tumors

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Sources for Pancreatic Islet Cell Tumors

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet