MCID: PNC044
MIFTS: 67

Pancreatitis malady

Endocrine diseases category

Summaries for Pancreatitis

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33MedlinePlus, 63Wikipedia, 19GeneReviews, 32MalaCards
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MedlinePlus:33 The pancreas is a large gland behind the stomach and close to the first part of the small intestine. it secretes digestive juices into the small intestine through a tube called the pancreatic duct. the pancreas also releases the hormones insulin and glucagon into the bloodstream. pancreatitis is inflammation of the pancreas. it happens when digestive enzymes start digesting the pancreas itself. pancreatitis can be acute or chronic. either form is serious and can lead to complications. acute pancreatitis occurs suddenly and usually goes away in a few days with treatment. it is often caused by gallstones. common symptoms are severe pain in the upper abdomen, nausea, and vomiting. treatment is usually a few days in the hospital for intravenous (iv) fluids, antibiotics, and medicines to relieve pain. chronic pancreatitis does not heal or improve. it gets worse over time and leads to permanent damage. the most common cause is heavy alcohol use. other causes include cystic fibrosis and other inherited disorders, high levels of calcium or fats in the blood, some medicines, and autoimmune conditions. symptoms include nausea, vomiting, weight loss, and oily stools. treatment may also be a few days in the hospital for intravenous (iv) fluids, medicines to relieve pain, and nutritional support. after that, you may need to start taking enzymes and eat a special diet. it is also important to not smoke or drink alcohol. nih: national institute of diabetes, digestive and kidney diseases

MalaCards: Pancreatitis, also known as pancreatitis nos, is related to pancreatic cancer and acute pancreatitis. An important gene associated with Pancreatitis is SMAD4 (SMAD family member 4), and among its related pathways are Pancreatic secretion and Lipoprotein metabolism. The drugs propantheline and propantheline bromide and the compounds calcium and glucose have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, pancreas and liver, and related mouse phenotypes are homeostasis/metabolism and digestive/alimentary.

Wikipedia:63 Pancreatitis is an inflammation of the pancreas. It has several causes and symptoms and requires... more...

GeneReviews summary for pancreatitis-ov

Aliases & Classifications for Pancreatitis

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Sources:
8Disease Ontology, 19GeneReviews, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreatitis 8 19 10 44 33 60
pancreatitis nos 8


External Ids:

Disease Ontology8 DOID:4989
MeSH34 D010195
NCIt39 C3306

Related Diseases for Pancreatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Pancreatitis, Chronic family:

Acute Pancreatitis pancreatitis
Autoimmune Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 923)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cancer32.1MUC4, RNASE1, SPINK1, SMAD4
2acute pancreatitis31.9REG3A, REG1A, CLPS, GP2, PNLIP, SPINK1
3adenocarcinoma31.8PDX1, SCTR, SMAD4, CEL, SPINK1, PNLIP
4alcoholic pancreatitis31.4SPINK1, CPB1
5exocrine pancreatic insufficiency31.3PPY, PNLIP, CELA3B, CEL, CELA1
6cystic fibrosis31.1SCTR, MUC4, REG3A, PNLIP, SPINK1, CELA3B
7diabetes mellitus31.1PDX1, PPY, REG1A, SPINK1
8pancreatic steatorrhea30.9CELA1, CELA3B, PNLIP
9insulinoma30.8PDX1, MAFA, REG3A, SMAD4
10steatorrhea30.8CLPS, PNLIP, CELA3B, CELA1
11adenoma30.8MUC4, REG1A, SPINK1, SMAD4
12obesity30.7CLPS, PNLIP
13gastrinoma30.5SMAD4, SCTR
14vipoma30.5SMAD4
15hereditary pancreatitis30.5SPINK1, REG1A
16pancreas disease30.3SMAD4, SPINK1, PNLIP, CLPS, REG1A, REG3A
17maturity-onset diabetes of the young30.2PDX1
18pancreatitis, chronic30.1MUC4, REG3A, REG1A, RNASE1, PNLIP, SPINK1
19esophageal cancer30.0MUC4, SPINK1, SMAD4
20tropical calcific pancreatitis29.8SPINK1
21stomach cancer29.5SMAD4, SPINK1, PNLIP, REG3A, MUC4
22pancreatic ductal adenocarcinoma11.1
23duodenitis10.8
24neuroendocrine tumor10.8
25islet cell tumor10.7
26hepatitis10.7
27pancreatic ductal carcinoma10.7
28pancreatic cystadenoma10.7
29cystadenoma10.7
30cholangitis10.6
31acinar cell carcinoma10.6
32panniculitis10.6
33obstructive jaundice10.6
34vascular cancer10.5
35pancreas adenocarcinoma10.5
36somatostatinoma10.5
37pancreatic serous cystadenoma10.5
38pancreatic somatostatinoma10.5
39von hippel-lindau disease10.5
40duodenal obstruction10.5
41pancreatic cystadenocarcinoma10.5
42pancreatic intraductal papillary-mucinous neoplasm10.5
43cystadenocarcinoma10.5
44choledochal cyst10.5
45sclerosing cholangitis10.4
46hypoglycemia10.4
47hepatitis a10.4
48pancreatic endocrine carcinoma10.4
49pancreatic cholera10.4
50peritonitis10.4

Graphical network of the top 20 diseases related to Pancreatitis:



Diseases related to pancreatitis

Clinical Features for Pancreatitis

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Drugs & Therapeutics for Pancreatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pancreatitis

Drug clinical trials:

Search ClinicalTrials for Pancreatitis

Search NIH Clinical Center for Pancreatitis

Search CenterWatch for Pancreatitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pancreatitis

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Anatomical Context for Pancreatitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pancreatitis:

32
Pancreatic islet, Pancreas, Liver, Testes, Endothelial, Lung, Small intestine, Kidney, Lymph node, T cells, Breast, Colon, Bone, B cells, Monocytes, Brain, Pituitary, Prostate, Spleen, Thyroid, Heart, Bone marrow, Ovary, Myeloid, Skin, Smooth muscle, Adipocyte, Spinal cord, Skeletal muscle, Salivary gland, Testis, Cortex, Adrenal cortex, Nk cells, Whole blood, Thymus, Cervix, Fetal liver

Animal Models for Pancreatitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pancreatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.9PDX1, SCTR, MAFA, REG3A, REG1A, REG1B
2MP:000538111.9PDX1, CLPS, PNLIP, SPINK1, CEL, SMAD4

Publications for Pancreatitis

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Sources:
50PubMed
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Articles related to Pancreatitis:

(show top 50)    (show all 14047)
idTitleAuthorsYear
1
Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. (24212882)
2014
2
Impact of hospital volume on outcomes in acute pancreatitis: a study using a nationwide administrative database. (24113818)
2014
3
Modified gastrointestinal failure score for patients with severe acute pancreatitis. (23361596)
2013
4
Pancreatic tumors and immature immunosuppressive myeloid cells in blood and spleen: role of inhibitory co-stimulatory molecules PDL1 and CTLA4. An in vivo and in vitro study. (23359812)
2013
5
Clinical necessity of the immunohistochemical reassessment of para-aortic lymph nodes in resected pancreatic ductal adenocarcinoma. (24179493)
2013
6
Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor. (22795353)
2013
7
The role of Fas expression on the occurrence of immunosuppression in severe acute pancreatitis. (23861115)
2013
8
Clinical and pathological differences between serum immunoglobulin G4-positive and -negative type 1 autoimmune pancreatitis. (23840149)
2013
9
Loss of HAI-1 participates in metastatic spreading of human pancreatic cancer cells in a mouse orthotopic transplantation model. (24147538)
2013
10
Hypertriglyceridemia-induced acute pancreatitis treated with insulin and heparin. (22261942)
2012
11
Double inferior vena cava does not complicate para-aortic nodal dissection for the treatment of pancreatic carcinoma. (22484593)
2012
12
Discrimination between sclerosing cholangitis-associated autoimmune pancreatitis and primary sclerosing cholangitis, cancer using intraductal ultrasonography. (21198911)
2011
13
Pancreatic serous cystadenocarcinoma with invasive growth into the colon and spleen. (22066125)
2011
14
A case of severe acute pancreatitis and cholangitis presenting as initial complaints of hepatocellular carcinoma. (21873799)
2011
15
Hepatocyte growth factor inhibits anoikis of pancreatic carcinoma cells through phosphatidylinositol 3-kinase pathway. (21499215)
2011
16
Continuous regional arterial infusion and laparotomic decompression for severe acute pancreatitis with abdominal compartment syndrome. (22171133)
2011
17
CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer. (20442202)
2010
18
Autoimmune pancreatitis--a new evolving pancreatic disease? (20862490)
2010
19
DNA repair gene polymorphisms and risk of pancreatic cancer. (19147782)
2009
20
Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer. (18992248)
2009
21
Thrombotic thrombocytopenic purpura precipitated by acute pancreatitis: a report of seven cases from a regional UK TTP registry. (19036107)
2009
22
Medical management of pancreatic neuroendocrine tumors. (18028508)
2008
23
Polymorphisms of the DNA repair genes XRCC1 and XPC: relationship to pancreatic cancer risk]. (17086695)
2006
24
New target therapies in advanced pancreatic cancer. (16807445)
2006
25
Signal pathway of hypoxia-inducible factor-1alpha phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells. (16278378)
2005
26
Fine-needle aspiration cytology of pancreatic somatostatinoma: the importance of immunohistochemistry for the cytologic diagnosis of pancreatic endocrine neoplasms. (16007666)
2005
27
Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets? (16249450)
2005
28
Chronic exposure of transforming growth factor beta 1 confers a more aggressive tumor phenotype through downregulation of p21(WAF1/CIP1) in conditionally immortalized pancreatic epithelial cells. (15300203)
2004
29
Expression profiling of the influence of RAS mutants on the TGFB1-induced phenotype of the pancreatic cancer cell line PANC-1. (14732924)
2004
30
Cyst fluid tumor-associated trypsin inhibitor may be helpful in the differentiation of cystic pancreatic lesions. (15239993)
2004
31
Calcitonin precursors in the prediction of severity of acute pancreatitis on the day of admission. (12555296)
2003
32
Peptide YY improves local and systemic parameters and prevents death in lethal necrotizing pancreatitis. (11741187)
2002
33
Future directions in the treatment of pancreatic cancer. (12577231)
2002
34
Adhesion molecules in human pancreatic cancer. (11815996)
2002
35
Evaluation of Ranson, Glasgow, APACHE-II, and APACHE-O criteria to predict severity in acute biliary pancreatitis. (11996072)
2001
36
Combined pure esophageal atresia, duodenal atresia, biliary atresia, and pancreatic ductal atresia: prenatal diagnostic features and review of the literature. (10813340)
2000
37
Discitis, infectious arthritis, and bacterial meningitis in a patient with pancreatic diabetes. (9213195)
1997
38
Identification of calcium-dependent phospholipase A2 isoforms in human and rat pancreatic islets and insulin secreting beta-cell lines. (8770912)
1996
39
Neuroendocrine differentiation in pancreatic duct carcinoma special emphasis on duct-endocrine cell carcinoma of the pancreas. (8950756)
1996
40
Exocrine pancreatic insufficiency after allogeneic bone marrow transplantation. (7642972)
1995
41
Chronic hereditary pancreatitis. (8053304)
1994
42
Lipoamidase activity in normal and mutagenized pancreatic cholesterol esterase (bile salt-stimulated lipase). (8471055)
1993
43
Association of the human spasmolytic polypeptide and an estrogen-induced breast cancer protein (pS2) with human pancreatic carcinoma. (1735955)
1992
44
Changes in plasma and duodenal cholecystokinin concentrations after pancreatic duct occlusion in rats. (1735360)
1992
45
Assignment of human pancreatic lipase gene (PNLIP) to chromosome 10q24-q26. (1783385)
1991
46
Pancreatitis and homocystinuria. (2116556)
1990
47
Gastrinoma presenting as chronic pancreatitis. (2301340)
1990
48
N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O- glycosylated on the 5th amino acid residue. (2493268)
1989
49
Mesotrypsin: a new inhibitor-resistant protease from a zymogen in human pancreatic tissue and fluid. (6698368)
1984
50
Hereditary pancreatitis. (5697978)
1968

Genetic Variations for Pancreatitis

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Expression for genes affiliated with Pancreatitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatitis

Search GEO for disease gene expression data for Pancreatitis.

Pathways for genes affiliated with Pancreatitis

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29KEGG, 53Reactome
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Pathways related to Pancreatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.9CELA3B, SCTR, CEL, CPB1, CPA1, PNLIP
2
Hide members
11.2CEL, CLPS, PNLIP
311.2CEL, PNLIP, CLPS
411.2PNLIP, CLPS, CEL
511.2CELA3B, CPB1, CPA1

Compounds for genes affiliated with Pancreatitis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Pancreatitis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2416.5RNASE1, CELA1, CLPS, PNLIP, SPINK1, CEL
2glucose4412.5PDX1, SMAD4, PNLIP, RNASE1, REG1A, REG3A
3serine4412.2PDX1, REG1A, RNASE1, SPINK1, CEL, PNLIP
4trypsinogen4411.8REG1A, REG3A, SPINK1, PNLIP
5oligonucleotide4411.7PDX1, SMAD4, CEL, RNASE1, MUC4
6orlistat44 59 1113.5CEL, PNLIP, CLPS
7nicotinamide44 1112.5REG1A, PDX1, REG3A
8triacylglycerol4411.4CEL, PNLIP, CLPS
9bicarbonate4411.3CEL, PNLIP, SCTR
10METHOXYUNDECYLPHOSPHINIC ACID1111.3CLPS, PNLIP
11(Hydroxyethyloxy)Tri(Ethyloxy)Octane1111.3PNLIP, CLPS
12ethylenediamine4411.2CEL, RNASE1
13p-nitrophenyl acetate4411.2PNLIP, CEL
14jzl 1845911.2PNLIP, CEL
15gsk 264220a5911.2CEL, PNLIP
16pristimerin5911.1PNLIP, CEL
17monoacylglycerol4411.0CEL, PNLIP
18paraoxon44 2411.9PNLIP, CEL
19h2o4410.7CLPS, RNASE1

GO Terms for genes affiliated with Pancreatitis

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16Gene Ontology
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Cellular components related to Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557613.6CPB1, REG1A, REG1B, REG3G, RNASE1, CLPS

Biological processes related to Pancreatitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1lipid digestionGO:04424111.4CLPS, PNLIP, CEL
2positive regulation of keratinocyte proliferationGO:01083811.1REG3G, REG3A
3negative regulation of keratinocyte differentiationGO:04561711.0REG3G, REG3A
4exocrine pancreas developmentGO:03101711.0CELA1, PDX1
5nitric oxide mediated signal transductionGO:00726311.0PDX1, MAFA
6intestinal cholesterol absorptionGO:03029910.9PNLIP, CEL
7positive regulation of wound healingGO:09030310.7REG3G, REG3A

Molecular functions related to Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:03024611.4REG3G, REG1B, REG1A, REG3A
2metallocarboxypeptidase activityGO:00418111.0CPA1, CPB1
3triglyceride lipase activityGO:00480610.7CEL, PNLIP

Products for genes affiliated with Pancreatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pancreatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet