MCID: PNC044
MIFTS: 64

Pancreatitis

Categories: Rare diseases, Gastrointestinal diseases, Bone diseases, Immune diseases, Endocrine diseases, Genetic diseases

Aliases & Classifications for Pancreatitis

Summaries for Pancreatitis

MedlinePlus : 40 The pancreas is a large gland behind the stomach and close to the first part of the small intestine. It secretes digestive juices into the small intestine through a tube called the pancreatic duct. The pancreas also releases the hormones insulin and glucagon into the bloodstream. Pancreatitis is inflammation of the pancreas. It happens when digestive enzymes start digesting the pancreas itself. Pancreatitis can be acute or chronic. Either form is serious and can lead to complications. Acute pancreatitis occurs suddenly and usually goes away in a few days with treatment. It is often caused by gallstones. Common symptoms are severe pain in the upper abdomen, nausea, and vomiting. Treatment is usually a few days in the hospital for intravenous (IV) fluids, antibiotics, and medicines to relieve pain. Chronic pancreatitis does not heal or improve. It gets worse over time and leads to permanent damage. The most common cause is heavy alcohol use. Other causes include cystic fibrosis and other inherited disorders, high levels of calcium or fats in the blood, some medicines, and autoimmune conditions. Symptoms include nausea, vomiting, weight loss, and oily stools. Treatment may also be a few days in the hospital for intravenous (IV) fluids, medicines to relieve pain, and nutritional support. After that, you may need to start taking enzymes and eat a special diet. It is also important to not smoke or drink alcohol. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Pancreatitis is related to autoimmune pancreatitis and tropical calcific pancreatitis, and has symptoms including gastrointestinal gas, nausea and vomiting and icterus. An important gene associated with Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Pancreatic secretion. The drugs Acetaminophen and Clonidine have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, pancreas and liver, and related phenotype is homeostasis/metabolism.

Wikipedia : 72 Pancreatitis is inflammation of the pancreas. The pancreas is a large organ behind the stomach that... more...

GeneReviews: NBK190101

Related Diseases for Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Acute Pancreatitis
Autoimmune Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1184)
# Related Disease Score Top Affiliating Genes
1 autoimmune pancreatitis 34.3 CFTR PRSS1
2 tropical calcific pancreatitis 33.9 CTRC PRSS1 PRSS2 REG1A SPINK1
3 pancreatic agenesis 1 33.9 CFTR PNLIP SCT SPINK1
4 pancreatic cancer 33.8 CCK PRSS1 REG3A SCT SPINK1 SST
5 exocrine pancreatic insufficiency 33.8 CCK CFTR PNLIP SCT
6 pancreatic steatorrhea 33.6 CCK PNLIP PRSS1 SCT
7 pancreatic cholera 33.4 CCK SCT SST
8 recurrent acute pancreatitis 33.0 CFTR CTRC LPL PRSS1 SCT SPINK1
9 alcoholic pancreatitis 32.8 CCK CFTR LPL PRSS1 SCT SPINK1
10 hyperinsulinemic hypoglycemia, familial, 2 32.4 SCT SST
11 pancreas disease 32.3 CCK PRSS1 REG3A SCT SPINK1 SST
12 biliary dyskinesia 32.2 CCK SCT
13 cystic fibrosis 32.0 CFTR PNLIP PRSS1 REG3A SCT SPINK1
14 multiple endocrine neoplasia, type i 32.0 CASR SCT SST
15 familial lipoprotein lipase deficiency 32.0 APOC2 LPL PNLIP
16 apolipoprotein c-ii deficiency 31.9 APOC2 LPL
17 glucagonoma 31.5 SCT SST
18 pancreatitis, hereditary 31.5 APOC2 CASR CCK CFTR CPA1 CTRC
19 acute pancreatitis 31.3 APOC2 CCK CPB1 LPL PLA2G2A PNLIP
20 duodenal ulcer 30.5 CCK SCT SST
21 gallbladder disease 30.1 CCK CFTR SST
22 duodenogastric reflux 29.9 CCK SCT SST
23 diarrhea 29.9 CCK SST TMPRSS15
24 duodenal gastrinoma 29.9 CCK SCT
25 linitis plastica 29.7 PRSS1 PRSS2
26 steatorrhea 29.7 APOC2 CCK CFTR PNLIP SCT SST
27 duodenal disease 29.5 CCK SCT
28 gastrointestinal system disease 29.3 CCK SCT SST
29 dumping syndrome 29.2 SCT SST
30 secretory diarrhea 28.9 CFTR SST
31 pancreatic lipase deficiency 12.4
32 pancreatic ductal adenocarcinoma 12.3
33 pancreatic ductal carcinoma 12.3
34 melanoma-pancreatic cancer syndrome 12.2
35 renal-hepatic-pancreatic dysplasia 12.2
36 pancreatic neuroendocrine tumor 12.2
37 neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 12.2
38 pancreatic mucinous cystadenoma 12.1
39 pancreatic cancer 4 12.1
40 pancreatic and cerebellar agenesis 12.1
41 pancreatic acinar cell adenocarcinoma 12.1
42 pancreatic serous cystadenoma 12.1
43 pancreatic agenesis 2 12.1
44 exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis 12.1
45 renal-hepatic-pancreatic dysplasia 2 12.0
46 pancreatic cancer 1 12.0
47 pancreatic cancer 3 12.0
48 congenital pancreatic cyst 12.0
49 pancreatic agenesis 12.0
50 pancreatitis, pediatric 12.0

Graphical network of the top 20 diseases related to Pancreatitis:



Diseases related to Pancreatitis

Symptoms & Phenotypes for Pancreatitis

UMLS symptoms related to Pancreatitis:


gastrointestinal gas, nausea and vomiting, icterus, heartburn, dyspepsia, diarrhea, constipation, abdominal pain

MGI Mouse Phenotypes related to Pancreatitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.4 CCK CFTR LPL PNLIP REG1A REG1B

Drugs & Therapeutics for Pancreatitis

Drugs for Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 424)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
2
Clonidine Approved Phase 4 4205-90-7 2803
3 Nefopam Approved, Investigational Phase 4 13669-70-0
4
Ropivacaine Approved Phase 4,Phase 2,Phase 3,Phase 1 84057-95-4 175805 71273
5
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
6
Tramadol Approved, Investigational Phase 4,Phase 2,Phase 3 27203-92-5 33741
7
Cefoperazone Approved, Investigational Phase 4 62893-19-0 44185
8
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
9
Meropenem Approved, Investigational Phase 4,Phase 1,Phase 2 119478-56-7 441130 64778
10
Metronidazole Approved Phase 4 443-48-1 4173
11
Somatostatin Approved, Investigational Phase 4,Phase 3 38916-34-6, 51110-01-1 53481605
12
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
13
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 2 53-86-1 3715
14
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 53608-75-6
15
Diclofenac Approved, Vet_approved Phase 4,Phase 1 15307-86-5 3033
16
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3 59467-70-8 4192
17
Ketorolac Approved Phase 4,Phase 2,Phase 3 74103-06-3, 66635-83-4 3826
18
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
19 Racepinephrine Approved Phase 4 329-65-7
20
Secretin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 108153-74-8
21
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
22
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
23
Menthol Approved Phase 4 2216-51-5 16666
24
Cilastatin Approved, Investigational Phase 4 82009-34-5 6435415 5280454
25
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
26
Protein C Approved Phase 4,Phase 1,Phase 2
27
Ceftazidime Approved Phase 4 72558-82-8, 78439-06-2 5481173
28
Octreotide Approved, Investigational Phase 4 83150-76-9 6400441 383414
29
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 2078-54-8 4943
30
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
31
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
32
Etomidate Approved Phase 4 33125-97-2 667484 36339
33
Meperidine Approved Phase 4 57-42-1 4058
34
Glycerol Approved, Investigational Phase 4,Phase 3 56-81-5 753
35
Prednisone Approved, Vet_approved Phase 4,Phase 1 53-03-2 5865
36
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2 7440-66-6 32051 23994
37
Azathioprine Approved Phase 4 446-86-6 2265
38
Thioguanine Approved Phase 4 154-42-7 2723601
39
Etanercept Approved, Investigational Phase 4 185243-69-0
40 Pinaverium Approved Phase 4 59995-65-2
41
Thrombin Approved, Investigational Phase 4
42
Leflunomide Approved, Investigational Phase 4 75706-12-6 3899
43
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
44
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 10883523 5280795 6221
45
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
46
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
47 Fat Emulsions, Intravenous Phase 4
48 Parenteral Nutrition Solutions Phase 4
49 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
50 Soybean oil, phospholipid emulsion Phase 4

Interventional clinical trials:

(show top 50) (show all 506)

# Name Status NCT ID Phase Drugs
1 Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
2 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
3 Multi-center Clinical Study of Early Antibios of Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
4 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Severe Acute Pancreatitis Unknown status NCT02691598 Phase 4 Infusion
5 Prophylactic Pancreatic Duct Stent Placement After ESP of Major Papillary Tumors; Prospective, Randomized Study Unknown status NCT01737463 Phase 4
6 Timing of Indomethacin Administration for the Prevention of Post-ERCP Pancreatitis (PEP) Completed NCT02111707 Phase 4 Rectal indomethacin 100mg one time before or after ERCP
7 Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis Completed NCT00957151 Phase 4 Creon
8 Evaluation of Pancreatic Tissue Penetration of Meronem® in the Prophylaxis of Septic Complications in Severe Pancreatitis Completed NCT00318994 Phase 4 Meropenem
9 Imipenem Prophylaxis in Patients With Acute Pancreatitis Completed NCT02897206 Phase 4 Imipenem;Placebo
10 Enteral Nutrition in Acute Pancreatitis Completed NCT01965873 Phase 4
11 Early Enteral Nutrition for Severe Acute Pancreatitis Completed NCT00995098 Phase 4
12 Activated Protein C in Severe Acute Pancreatitis Completed NCT01017107 Phase 4 Activated protein C
13 Post ERCP Pancreatitis Prevention in Average Risk Patients Completed NCT01784445 Phase 4 Ceftazidime
14 Acute Pancreatitis and Acute Fluid Collections Completed NCT00786929 Phase 4 Conservative treatment
15 Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4 Vitamin D3 (Cholecalciferol)
16 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
17 Somatostatin, Octreotide, Pentoxyfilline in the Prevention of Post-ERCP Pancreatitis and Molecular Markers Completed NCT00222092 Phase 4
18 A Study to Determine if Antibiotics Prevent Infection in the Pancreas of Patients Where Part of the Pancreas Has Died Completed NCT00061438 Phase 4 meropenem
19 Dexmedetomidine Versus Placebo in Endoscopic Retrograde Cholangiopancreatography (ERCP) Sedation Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
20 Sitagliptin Therapy to Improve Outcomes After Islet Autotransplant Completed NCT01186562 Phase 4 Sitagliptin;Placebo
21 Enzyme Suppletion in Exocrine Pancreatic Dysfunction Completed NCT01430234 Phase 4 Panzytrat 25.000 FIP-E units of Lipase
22 A Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation Completed NCT01408264 Phase 4
23 Assess the Effect of Erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube Completed NCT00999232 Phase 4 Erythromycin;Placebo
24 Prospective Study of Celiac Block Injection: 1 vs. 2 Completed NCT00583479 Phase 4
25 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
26 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
27 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Completed NCT00560157 Phase 4
28 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
29 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
30 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
31 A Post Marketing Surveillance Study for NutropinAq® in Adults With Growth Hormone Deficiency Completed NCT00455884 Phase 4
32 Thiopurine Induced Pancreatitis in IBD Patients Recruiting NCT02281799 Phase 4 Azathioprine
33 Rectal Indomethacin to Prevent Post ESWL-pancreatitis Recruiting NCT02797067 Phase 4 indomethacin suppository;glycerin suppository
34 Treatment of Acute Pancreatitis With Ketorolac Recruiting NCT02885441 Phase 4 Ketorolac;Placebo
35 WallFlex Biliary Fully Covered (FC) Chronic Pancreatitis Study Recruiting NCT01543256 Phase 4
36 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Recruiting NCT02839356 Phase 4 epinephrine;normal saline
37 Anti-inflammatory Therapy to Improve Outcomes After TPIAT Recruiting NCT02713997 Phase 4 etanercept;Alpha 1-Antitrypsin
38 Early Oral Versus Enteral Nutrition After Pancreatoduodenectomy Recruiting NCT01642875 Phase 4
39 Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction Recruiting NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
40 Intraductal Secretin Stimulation Test: What Is the Proper Collection Time? Recruiting NCT03263481 Phase 4 Human Secretin for injection 16 mcg
41 The Effect of Application of TachoSil® in Pancreatoduodenectomy Recruiting NCT03269955 Phase 4 Fibrinogen/thrombin-coated collagen patch
42 Leflunomide for Maintenance of Remission in IgG4 Related Disease Recruiting NCT02703194 Phase 4 Prednisone;Leflunomide
43 COX-2 Inhibitor to Prevent Post-ERCP Pancreatitis Not yet recruiting NCT02964403 Phase 4 Cox-2;Indomethacin
44 Oral Resveratrol to Prevent Post-ERCP Pancreatitis Not yet recruiting NCT02947932 Phase 4 Resveratrol;Indomethacin
45 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal Not yet recruiting NCT03082469 Phase 4
46 A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis Not yet recruiting NCT02465138 Phase 4 Ketorolac;Placebo
47 Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis Not yet recruiting NCT03342807 Phase 4 Insulin
48 Ulinastatin in Severe Acute Pancreatitis Suspended NCT01132521 Phase 4 ulinastatin;placebo
49 Diclofenac for the Prevention of Post-ERCP Pancreatitis in Higher Risk Patients Terminated NCT00428025 Phase 4 diclofenac;placebo
50 Rectal Indomethacin in the Prevention of Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis in High Risk Patients Terminated NCT00820612 Phase 4 Indomethacin

Search NIH Clinical Center for Pancreatitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: pancreatitis

Genetic Tests for Pancreatitis

Genetic tests related to Pancreatitis:

# Genetic test Affiliating Genes
1 Pancreatitis 28

Anatomical Context for Pancreatitis

MalaCards organs/tissues related to Pancreatitis:

38
Pancreatic Islet, Pancreas, Liver, Testes, Endothelial, Lung, T Cells

Publications for Pancreatitis

Articles related to Pancreatitis:

(show top 50) (show all 17709)
# Title Authors Year
1
Etiology Is Linked to the Length of Admission in Patients With Acute Pancreatitis: Is Novel Endoscopy an Unrecognized Cause? ( 29424812 )
2018
2
Comparison of Practice Guidelines, BRCAPRO, and Genetic Counselor Estimates to Identify Germline BRCA1 and BRCA2 Mutations in Pancreatic Cancer. ( 29441441 )
2018
3
Inhibition of the MEK/ERK pathway augments nab-paclitaxel-based chemotherapy effects in preclinical models of pancreatic cancer. ( 29435178 )
2018
4
Recurrent Acute Pancreatitis in Children: Do not forget the "Worms". ( 29095350 )
2018
5
Autophagy Strengthens Intestinal Mucosal Barrier by Attenuating Oxidative Stress in Severe Acute Pancreatitis. ( 29427225 )
2018
6
Diagnostic Performance of Measurement of Fecal Elastase-1 in Detection of Exocrine Pancreatic Insufficiency - Systematic Review and Meta-analysis. ( 29374614 )
2018
7
Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells. ( 29107110 )
2018
8
A new panel of pancreatic cancer biomarkers discovered using a mass spectrometry-based pipeline. ( 29438371 )
2018
9
Expression of podoplanin in stromal fibroblasts plays a pivotal role in the prognosis of patients with pancreatic cancer. ( 28702871 )
2018
10
Investigation into metastatic processes and the therapeutic effects of gemcitabine on human pancreatic cancer using an orthotopic SUIT-2 pancreatic cancer mouse model. ( 29435042 )
2018
11
Urgent endoscopic retrograde cholangiopancreatography is not superior to early ERCP in acute biliary pancreatitis with biliary obstruction without cholangitis. ( 29401491 )
2018
12
Feasibility of EUS-guided Nd:YAG laser ablation of unresectable pancreatic adenocarcinoma. ( 29452076 )
2018
13
Tau ablation in mice leads to pancreatic I^ cell dysfunction and glucose intolerance. ( 29401605 )
2018
14
Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement. ( 29151502 )
2018
15
Focal Autoimmune Pancreatitis Mimicking Pancreatic Cancer on FDG PET/CT Imaging. ( 29189377 )
2018
16
A case of gastric wall implantation caused by EUS-FNA 22 months after pancreatic cancer resection. ( 29451172 )
2018
17
Pancreaticoportal Fistula Formation as a Consequence of Recurrent Acute Pancreatitis: Clinical and Imaging Considerations. ( 29441227 )
2018
18
Fine-needle aspiration of a pancreatic neuroendocrine tumor with prominent rhabdoid features. ( 29359517 )
2018
19
Endoscopic ultrasound guided 22 gauge core needle biopsy for the diagnosis of Autoimmune pancreatitis. ( 29338920 )
2018
20
Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal carcinoma treated with individualized, neoepitope-derived multipeptide vaccines: a case report. ( 29409514 )
2018
21
Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic I^-cells. ( 29128354 )
2018
22
Circulating Tumor Cells Predict Occult Metastatic Disease and Prognosis in Pancreatic Cancer. ( 29442211 )
2018
23
MiR-7-5p functions as a tumor suppressor by targeting SOX18 in pancreatic ductal adenocarcinoma. ( 29408481 )
2018
24
Complex HuR function in pancreatic cancer cells. ( 29452455 )
2018
25
Genotype-phenotype pancreatic neuroendocrine tumor relationship in multiple endocrine neoplasia type 1 patients: A 23-year experience at a single institution. ( 29122330 )
2018
26
Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. ( 29396028 )
2018
27
Pancreatitis associated with calciphylaxis successfully treated with sodium thiosulfate. ( 29387772 )
2018
28
Serum Osteopontin Is Associated With Organ Failure in Patients With Acute Pancreatitis. ( 29424811 )
2018
29
The protective effects of rutaecarpine on acute pancreatitis. ( 29435045 )
2018
30
Focal Adhesion Kinase a Potential Therapeutic Target for Pancreatic Cancer and Malignant Pleural Mesothelioma. ( 29303405 )
2018
31
A case of pancreatic neuroendocrine tumor with multiple cystic components of various sizes. ( 29270782 )
2018
32
TH588, an MTH1 inhibitor, enhances phenethyl isothiocyanate-induced growth inhibition in pancreatic cancer cells. ( 29435064 )
2018
33
Incidental Detection of Asymptomatic Brain Metastases on<sup>18</sup>F-fluoride Positron Emission Tomography/Computed Tomography and<sup>68</sup>Ga DOTANOC Positron Emission Tomography/Computed Tomography in a Patient with Concomitant Breast Carcinoma and a Pancreatic Neuroendocrine Tumor. ( 29398971 )
2018
34
13C-Mixed Triglyceride Breath Test and Fecal Elastase as an Indirect Pancreatic Function Test in Cystic Fibrosis Infants. ( 29432279 )
2018
35
Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180. ( 29061505 )
2018
36
Counterpoint: Weighing the Risks and Benefits of Neoadjuvant Therapy in Resectable Pancreatic Cancer. ( 29447421 )
2018
37
Pancreatic panniculitis: the "bright" side of the moon in solid cancer patients. ( 29301491 )
2018
38
Serial evaluation of the SOFA score is reliable for predicting mortality in acute severe pancreatitis. ( 29443733 )
2018
39
Simultaneous Glucagon and Vasoactive Intestinal Peptide Producing Pancreatic Neuroendocrine Tumors in a Patient With Multiple Endocrine Neoplasia Type 1: A Case Report and Literature Review. ( 29232343 )
2018
40
Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation. ( 28913878 )
2018
41
Acute Pancreatitis and Pancreatic Cancer Risk: A Nationwide Matched-cohort Study in Denmark. ( 29432727 )
2018
42
Fibrosis-related miRNAs as serum biomarkers for pancreatic ductal adenocarcinoma. ( 29435115 )
2018
43
Hepatobiliary and Pancreatic: Pregnancy induced hepatic veno-occlusive disease requiring liver transplantation. ( 29284078 )
2018
44
Acute pancreatitis: ascaris in the pancreatic duct. ( 29452432 )
2018
45
POINT: Weighing the Risks and Benefits of Neoadjuvant Therapy in Resectable Pancreatic Cancer. ( 29447420 )
2018
46
Intrapancreatic Accessory Spleen Masquerading as a Pancreatic Neuroendocrine Tumor. ( 29404984 )
2018
47
Localisation of occult extra-pancreatic insulinoma using glucagon-like peptide-1 receptor molecular imaging. ( 29314520 )
2018
48
Pyruvate kinase type M2 contributes to the development of pancreatic ductal adenocarcinoma by regulating the production of metabolites and reactive oxygen species. ( 29393401 )
2018
49
A phase I trial of the I^-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma. ( 29438372 )
2018
50
Letter to the editors regarding: genotype-phenotype pancreatic neuroendocrine tumor relationship in multiple endocrine neoplasia type 1 patients: a 23-year experience at a single institution. ( 29338880 )
2018

Variations for Pancreatitis

Copy number variations for Pancreatitis from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 194974 5 147184338 147191453 Deletion SPINK1 Pancreatitis
2 220321 7 137300000 142800000 Triplication PRSS1 Pancreatitis
3 220322 7 137300000 142800000 Triplication PRSS2 Pancreatitis
4 221070 7 142136892 142140501 Triplication PRSS1 Pancreatitis
5 221298 7 142800000 147500000 Triplication PRSS1 Pancreatitis

Expression for Pancreatitis

Search GEO for disease gene expression data for Pancreatitis.

GO Terms for Pancreatitis

Cellular components related to Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 APOC2 CCK CPA1 CPB1 CTRC LPL
2 extracellular space GO:0005615 9.44 APOC2 CCK CPA1 CPB1 LPL PLA2G2A
3 very-low-density lipoprotein particle GO:0034361 9.26 APOC2 LPL
4 chylomicron GO:0042627 9.16 APOC2 LPL

Biological processes related to Pancreatitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.8 CPA1 CPB1 CTRC PRSS1 PRSS2 TMPRSS15
2 digestion GO:0007586 9.54 PRSS1 PRSS2 SST
3 triglyceride homeostasis GO:0070328 9.49 APOC2 LPL
4 sperm capacitation GO:0048240 9.48 CFTR SPINK1
5 cobalamin metabolic process GO:0009235 9.46 CTRC PRSS1
6 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.43 LPL PLA2G2A
7 retinoid metabolic process GO:0001523 9.43 APOC2 LPL PNLIP
8 chylomicron remodeling GO:0034371 9.4 APOC2 LPL
9 very-low-density lipoprotein particle remodeling GO:0034372 9.16 APOC2 LPL
10 antimicrobial humoral response GO:0019730 9.13 PLA2G2A PRSS2 REG3A
11 lipid catabolic process GO:0016042 8.92 APOC2 LPL PLA2G2A PNLIP

Molecular functions related to Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.56 CTRC PRSS1 PRSS2 TMPRSS15
2 hormone activity GO:0005179 9.5 CCK SCT SST
3 serine-type peptidase activity GO:0008236 9.46 CTRC PRSS1 PRSS2 TMPRSS15
4 peptidase activity GO:0008233 9.43 CPA1 CPB1 CTRC PRSS1 PRSS2 TMPRSS15
5 triglyceride lipase activity GO:0004806 9.37 LPL PNLIP
6 hydrolase activity GO:0016787 9.32 CFTR CPA1 CPB1 CTRC LPL PLA2G2A

Sources for Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....