MCID: PNC044
MIFTS: 69

Pancreatitis malady

Genetic diseases, Endocrine diseases, Gastrointestinal diseases, Rare diseases, Bone diseases, Immune diseases categories
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Summaries for Pancreatitis

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MedlinePlus:33 The pancreas is a large gland behind the stomach and close to the first part of the small intestine. it secretes digestive juices into the small intestine through a tube called the pancreatic duct. the pancreas also releases the hormones insulin and glucagon into the bloodstream. pancreatitis is inflammation of the pancreas. it happens when digestive enzymes start digesting the pancreas itself. pancreatitis can be acute or chronic. either form is serious and can lead to complications. acute pancreatitis occurs suddenly and usually goes away in a few days with treatment. it is often caused by gallstones. common symptoms are severe pain in the upper abdomen, nausea, and vomiting. treatment is usually a few days in the hospital for intravenous (iv) fluids, antibiotics, and medicines to relieve pain. chronic pancreatitis does not heal or improve. it gets worse over time and leads to permanent damage. the most common cause is heavy alcohol use. other causes include cystic fibrosis and other inherited disorders, high levels of calcium or fats in the blood, some medicines, and autoimmune conditions. symptoms include nausea, vomiting, weight loss, and oily stools. treatment may also be a few days in the hospital for intravenous (iv) fluids, medicines to relieve pain, and nutritional support. after that, you may need to start taking enzymes and eat a special diet. it is also important to not smoke or drink alcohol. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Pancreatitis is related to pancreatic cancer and hereditary pancreatitis. An important gene associated with Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are ethanol degradation II and Abacavir Pathway, Pharmacokinetics/Pharmacodynamics. The drugs propantheline and propantheline bromide and the compounds epft and h2dids have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, pancreas and liver, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Wikipedia:65 Pancreatitis is defined as inflammation of the pancreas. It has several causes and symptoms and requires... more...

GeneReviews summary for pancreatitis-ov

Aliases & Classifications for Pancreatitis

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Pancreatitis, Aliases & Descriptions:

Name: Pancreatitis 8 19 10 44 33 62


Classifications:



External Ids:

Disease Ontology8 DOID:4989
NCIt39 C3306
MeSH34 D010195

Related Diseases for Pancreatitis

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Diseases in the Hereditary Pancreatitis family:

Acute Pancreatitis pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Spink1-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Cftr-Related Hereditary Pancreatitis Pancreatitis, Chronic
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1025)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cancer32.6SCT, SPINK1, CCK
2hereditary pancreatitis31.9PRSS1, CTRC, SPINK1
3tropical calcific pancreatitis31.7SPINK1
4exocrine pancreatic insufficiency31.6CFTR, CCK, ELANE, SCT
5recurrent acute pancreatitis31.3LPL, SOD1, SPINK1, SCT, CFTR
6glucagonoma31.3CCK, SCT
7adenocarcinoma31.1ALDH2, SPINK1, SCT, ADH1C, ADH1B, PRSS1
8cholera31.0CFTR, SCT, CCK
9hyperinsulinism31.0LPL, CCK, SCT
10duodenal ulcer31.0CCK, SCT
11cystic fibrosis31.0PRSS1, SPINK1, CFTR, SCT, ELANE, LPL
12steatorrhea30.9CCK, ELANE, TMPRSS15, SCT, CFTR
13adenoma30.9ADH1C, SCT, CTSB, SPINK1, REG1A
14gallbladder disease30.9CCK, CFTR
15duodenogastric reflux30.8CCK
16glucose intolerance30.8APOC2, LPL, ALDH2
17gastritis30.8SCT, CCK
18hyperglycemia30.8LPL, CCK, SCT, SOD1
19diabetes mellitus30.7ALDH2, LPL, SOD1, SCT, APOC2, CCK
20alcoholic pancreatitis30.7ADH1C, SPINK1, CFTR, CPB1, SCT, ALDH2
21liver cirrhosis30.5ADH1B, ALDH2, ADH1C, SCT
22aspergillosis30.5ELANE
23familial hypertriglyceridemia30.5LPL, APOC2
24morbid obesity30.4LPL, CCK
25biliary dyskinesia30.3CCK
26alcohol abuse30.3ALDH2, ADH1C
27atrophic gastritis30.2SOD1, SCT
28alcoholic liver cirrhosis30.1ALDH2, ADH1B, ADH1C, SOD1
29type 2 diabetes mellitus29.9ALDH2, SPINK1, CTSB, CCK, LPL, APOC2
30lung cancer29.8CTSB, ALDH2, CCK, LPL, ADH1C, SPINK1
31fatty liver disease29.8ALDH2, LPL, SOD1
32acute pancreatitis29.7ADH1C, REG3A, REG1A, LPL, CCK, ALDH2
33rheumatoid arthritis29.7PRSS2, CTSB, LPL, ELANE, CFTR
34vascular disease29.6LPL, ELANE, SOD1, APOC2
35colorectal cancer29.5PRSS2, SPINK1, CTSB, ALDH2, CCK, LPL
36pancreas disease29.5CCK, SPINK1, CFTR, SCT, TMPRSS15, ELANE
37liver cancer29.5ELANE, REG1A, ALDH2, REG3A, ADH1B, SCT
38alzheimer's disease29.5CTSB, ALDH2, CCK, REG1A, SOD1, ELANE
39pancreatitis, chronic28.7ELANE, TMPRSS15, CCK, LPL, REG1A, REG3A
40pancreatic ductal adenocarcinoma11.1
41autoimmune pancreatitis11.1
42duodenitis10.9
43neuroendocrine tumor10.8
44islet cell tumor10.8
45pancreatic endocrine tumors10.8
46endotheliitis10.8
47hepatitis10.8
48cystadenoma10.7
49pancreatic islet cell tumors10.7
50pancreatic ductal carcinoma10.7

Graphical network of the top 20 diseases related to Pancreatitis:



Diseases related to pancreatitis

Symptoms for Pancreatitis

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Drugs & Therapeutics for Pancreatitis

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Drug clinical trials:

Search ClinicalTrials for Pancreatitis

Search NIH Clinical Center for Pancreatitis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Pancreatitis

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Anatomical Context for Pancreatitis

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MalaCards organs/tissues related to Pancreatitis:

32
Pancreatic islet, Pancreas, Liver, Testes, Endothelial, Lung, Small intestine, Kidney, Lymph node, T cells, Breast, Colon, Neutrophil, Bone, Monocytes, B cells, Brain, Spleen, Prostate, Pituitary, Thyroid, Bone marrow, Heart, Ovary, Myeloid, Smooth muscle, Skin, Spinal cord, Adipocyte, Skeletal muscle, Salivary gland, Testis, Cortex, Adrenal cortex, Whole blood, Nk cells, Thymus, Cervix, Fetal liver

Animal Models for Pancreatitis or affiliated genes

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MGI Mouse Phenotypes related to Pancreatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.9SPINK1, CFTR, SOD1, REG1A, CCK, CTSB
2MP:00053766.5SPINK1, CFTR, SCT, TMPRSS15, SOD1, ADH1C

Publications for Pancreatitis

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Articles related to Pancreatitis:

(show top 50)    (show all 14355)
idTitleAuthorsYear
1
Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cells. (24297612)
2014
2
Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors. (24025713)
2014
3
Coexisting pancreatic mucinous cyst adenoma and adrenal lymphangioma. (25224209)
2014
4
Perineural mast cells are specifically enriched in pancreatic neuritis and neuropathic pain in pancreatic cancer and chronic pancreatitis. (23555989)
2013
5
Early enteral nutrition is superior to delayed enteral nutrition for the prevention of infected necrosis and mortality in acute pancreatitis. (23508012)
2013
6
Serum immunoglobulin G4 associated with number and distribution of extrapancreatic lesions in type 1 autoimmune pancreatitis patients. (21929654)
2012
7
Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma? (22436573)
2012
8
Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta. (21700708)
2011
9
Transthyretin, identified by proteomics, is overabundant in pancreatic juice from pancreatic carcinoma and originates from pancreatic islets. (20949480)
2011
10
Polyarthritis with chondronecrosis associated with osteonecrosis, panniculitis and pancreatitis. (19575201)
2010
11
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
12
Education and imaging. Hepatobiliary and pancreatic: Epithelioid hemangioendothelioma. (19335787)
2009
13
Panniculitis in a patient presenting with a pancreatic tumour and polyarthritis: a case report. (19830189)
2009
14
Enhanced antitumor effect of combined gemcitabine and proton radiation in the treatment of pancreatic cancer. (19506533)
2009
15
Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth. (19610136)
2009
16
Protective effect of lycopene on oxidative stress-induced cell death of pancreatic acinar cells. (19723106)
2009
17
Obesity alters cytokine gene expression and promotes liver injury in rats with acute pancreatitis. (18223607)
2008
18
Fucosylated haptoglobin is a novel marker for pancreatic cancer: detailed analyses of oligosaccharide structures. (18646007)
2008
19
Pancreatic laceration and portal vein thrombosis in blunt trauma abdomen. (20011472)
2008
20
Evaluation of topoisomerase IIa expression in pancreatic ductal adenocarcinoma: a pilot study using chromogenic in situ hybridization and immunohistochemistry on tissue microarrays. (17449965)
2007
21
Expression of heparanase and nuclear factor kappa B in pancreatic adenocarcinoma]. (17715045)
2007
22
Role of BRCA1 and BRCA2 mutations in pancreatic cancer. (16973716)
2007
23
DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients. (17914106)
2007
24
Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression. (17116388)
2007
25
N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption. (16705170)
2006
26
Recurrent acute pancreatitis in a patient with type IIb hyperlipoproteinemia: a case report and review of the literature in Korea. (16502498)
2006
27
Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer. (16865243)
2006
28
Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. (16568310)
2006
29
Hereditary pancreatitis and secondary screening for early pancreatic cancer. (16358943)
2005
30
Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation. (14565847)
2004
31
Anti-cytokine therapy for severe acute pancreatitis]. (15552897)
2004
32
Gene therapy of pancreatic cancer with green fluorescent protein and tumor necrosis factor-related apoptosis-inducing ligand fusion gene expression driven by a human telomerase reverse transcriptase promoter. (12900367)
2003
33
BRCA2 germline mutations in familial pancreatic carcinoma. (12569143)
2003
34
Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma. (12843152)
2003
35
Laser microdissection of small tissue samples--application to chronic pancreatitis tissues. (12924436)
2003
36
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. (12235117)
2002
37
Detection of choledocholithiasis by EUS in acute pancreatitis: a prospective evaluation in 100 consecutive patients. (11522972)
2001
38
Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells. (10996854)
2000
39
Control of pancreatic bile-salt-dependent-lipase secretion by the glucose-regulated protein of 94 kDa (Grp94). (11104697)
2000
40
The POU domain transcription factor Tst-1 activates somatostatin receptor 1 gene expression in pancreatic beta -cells. (10866997)
2000
41
Diagnosis of lipid malabsorption in patients with chronic pancreatitis: a new indirect test using postprandial plasma apolipoprotein B-48. (10566720)
1999
42
Imaging of neuroendocrine gastro-entero-pancreatic tumours using radiolabelled somatostatin analogues. (10604128)
1999
43
Intraductal secretin test is as useful as duodenal secretin test in assessing exocrine pancreatic function. (9073129)
1997
44
Enzymatic markers of gallstone-induced pancreatitis identified by ROC curve analysis, discriminant analysis, logistic regression, likelihood ratios, and information theory. (7536644)
1995
45
Pneumocystis carinii pneumonia complicating somatostatin therapy of Cushing's syndrome in a patient with metastatic pancreatic islet cell carcinoma and Zollinger-Ellison syndrome. (1672788)
1991
46
Renal-hepatic-pancreatic dysplasia and its variants. (1741971)
1991
47
Effects of cholecystokinin-receptor blockade on pancreatic and biliary function in healthy volunteers. (2019374)
1991
48
Electron microscopic and immunoelectron microscopic demonstration of pancreatic polypeptide cells in glucagonoma: colocalization of pancreatic peptide and glucagon in single secretory granules. (2537546)
1989
49
Indomethacin-responsive pancreatic cholera. (197410)
1977
50
Meconium ileus; with cystic pancreatic fibrosis and early pulmonary complications. (13422754)
1957

Variations for Pancreatitis

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Expression for genes affiliated with Pancreatitis

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Expression patterns in normal tissues for genes affiliated with Pancreatitis

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Pathways for genes affiliated with Pancreatitis

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Pathways related to Pancreatitis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
acetate conversion to acetyl-CoA37
oxidative ethanol degradation III37
ethanol degradation IV37
10.0ALDH2, ADH1B
29.9ADH1B, ADH1C
3
Show member pathways
9.8ELANE, PRSS2, PRSS1
49.7CPB1, PRSS1, PRSS2
5
Show member pathways
9.6ALDH2, ADH1B, ADH1C
6
Show member pathways
mitochondrial L-carnitine shuttle pathway37
Saturated fatty acid biosynthesis60
9.6ALDH2, ADH1B, ADH1C
7
Show member pathways
9.6ALDH2, ADH1B, ADH1C
8
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
9.6ALDH2, ADH1B, ADH1C
9
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
9.6ADH1C, ADH1B, ALDH2
10
Show member pathways
9.6PRSS1, PRSS2, ELANE, CTSB
119.5PRSS2, PRSS1, CPB1, CFTR

Compounds for genes affiliated with Pancreatitis

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Compounds related to Pancreatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1epft4410.4SCT, CCK
2h2dids4410.3SCT, CFTR
3trioleoylglycerol4410.1APOC2, LPL
4taurodeoxycholate4410.1CCK, SCT
5betaine aldehyde44 2411.1ADH1C, ALDH2, ADH1B
6l-bpa4410.1CCK, SCT
73a,7a-Dihydroxy-5b-cholestan-26-al2410.0ADH1B, ALDH2, ADH1C
8carbachol44 28 1112.0CFTR, SCT, CCK, CTSB
9biotin44 24 1112.0SCT, LPL, CTSB, CFTR
10cerulein449.9SCT, ELANE, CCK, CTSB
11saccharin44 210.9CCK, ELANE
12ibmx44 61 2811.9CCK, LPL, SCT, CFTR
13rsai449.9ALDH2, ADH1C, ADH1B, APOC2
14aprotinin44 1110.9TMPRSS15, PRSS1, ELANE, CTSB
15nitroglycerin44 1110.9ELANE, SOD1, ALDH2
16probucol44 1110.9LPL, REG3A, SOD1
17acetaldehyde28 44 2411.8ALDH2, ADH1C, ADH1B
18caffeine44 28 2 50 24 1114.8CFTR, ELANE, CCK, LPL
19taurocholate449.8CCK, LPL, TMPRSS15, CFTR, SCT
20thyroxine44 2410.8SCT, LPL, CTSB, ELANE
21sodium nitroprusside449.8CCK, ALDH2, SOD1, ELANE
22carbon449.7CTSB, LPL, ELANE, CCK
23valine449.7CTSB, LPL, CFTR, ELANE
24alpha tocopherol449.7ELANE, LPL, ALDH2, SOD1
25isoproterenol44 1110.7SCT, ELANE, LPL, CTSB, CFTR
26indomethacin44 28 61 1112.7CTSB, CFTR, SCT, SOD1, LPL
27norepinephrine44 24 1111.6CCK, CFTR, LPL, SCT, ELANE
28acetylcholine44 50 28 24 1113.6LPL, SCT, CCK, ELANE, CFTR
29glycerol44 24 1111.6ADH1C, ADH1B, LPL, CCK, CFTR
30dopamine44 28 24 1112.6ALDH2, CCK, CFTR, SCT, ADH1B
31ethanol44 50 24 1112.6ADH1C, SCT, ADH1B, ALDH2, CTSB
32creatinine449.5ALDH2, SOD1, APOC2, CTSB, SPINK1
33polyacrylamide449.5ALDH2, APOC2, ADH1B, CTSB
34cyclosporin a44 28 6111.4LPL, CCK, CTSB, ELANE, CFTR, SCT
35pge2449.4CCK, SCT, CTSB, CFTR, ELANE, LPL
36nadph44 2410.4CTSB, ALDH2, ADH1B, ADH1C, SOD1
37lysine449.4APOC2, TMPRSS15, CPB1, ALDH2, SCT
38heparin44 28 24 1112.3TMPRSS15, ELANE, LPL, APOC2, CTSB
39retinoic acid44 2410.3ELANE, ALDH2, CCK, APOC2, SCT, CFTR
40glutamine449.2SCT, CFTR, CTSB, LPL, CCK, ALDH2
41vitamin a44 24 1111.0APOC2, ADH1B, ALDH2, SOD1, ADH1C, ELANE
42zinc44 2410.0SCT, CPB1, SOD1, ADH1C, CTSB, ADH1B
43adenylate449.0CFTR, LPL, CCK, SCT, ELANE
44glutamate448.9CCK, CFTR, SCT, SOD1, ELANE, LPL
45cysteine448.9ELANE, SCT, CTSB, ALDH2, PRSS2, PRSS1
46arginine448.8CTSB, SCT, ALDH2, TMPRSS15, CCK, PRSS1
47calcium44 50 24 1111.6CCK, CTRC, CTSB, PRSS2, REG1A, PRSS1
48glucose448.4SCT, ALDH2, REG1A, CCK, CTSB, LPL
49serine448.3CTSB, CTRC, ELANE, PRSS2, PRSS1, TMPRSS15
50trypsinogen447.8TMPRSS15, SCT, PRSS1, PRSS2, ELANE, REG3A

GO Terms for genes affiliated with Pancreatitis

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Cellular components related to Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:0426279.9LPL, APOC2
2very-low-density lipoprotein particleGO:0343619.7LPL, APOC2
3extracellular matrixGO:0310129.7PRSS2, LPL, SOD1
4extracellular spaceGO:0056158.7APOC2, SOD1, PRSS2, REG3A, LPL, CCK
5extracellular regionGO:0055766.9CTSB, SPINK1, SCT, APOC2, CPB1, SOD1

Biological processes related to Pancreatitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1chylomicron remodelingGO:03437110.3LPL, APOC2
2very-low-density lipoprotein particle remodelingGO:03437210.2LPL, APOC2
3triglyceride homeostasisGO:07032810.0LPL, APOC2
4ethanol oxidationGO:0060699.9ALDH2, ADH1B, ADH1C
5positive regulation of keratinocyte proliferationGO:0108389.9REG3A, REG3G
6collagen catabolic processGO:0305749.9PRSS2, ELANE, CTSB
7negative regulation of keratinocyte differentiationGO:0456179.9REG3G, REG3A
8extracellular matrix disassemblyGO:0226179.8ELANE, PRSS2, PRSS1, CTSB
9proteolysisGO:0065089.8ELANE, CTRC, CTSB, PRSS2
10positive regulation of wound healingGO:0903039.7REG3G, REG3A
11response to drugGO:0424939.6CFTR, APOC2, SOD1, LPL
12extracellular matrix organizationGO:0301989.6CTSB, ELANE, PRSS2, PRSS1
13xenobiotic metabolic processGO:0068059.3ALDH2, ADH1C, ADH1B
14small molecule metabolic processGO:0442818.9APOC2, ADH1C, ADH1B, PRSS1, LPL, ALDH2

Molecular functions related to Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:0082339.4ELANE, CTRC, CTSB
2serine-type endopeptidase activityGO:0042529.2CTRC, ELANE, PRSS2, PRSS1, TMPRSS15
3carbohydrate bindingGO:0302469.2REG1A, REG3G, REG3A

Products for genes affiliated with Pancreatitis

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Sources for Pancreatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet