MCID: PNC044
MIFTS: 67

Pancreatitis malady

Endocrine diseases category

Summaries for Pancreatitis

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33MedlinePlus, 63Wikipedia, 19GeneReviews, 32MalaCards
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MedlinePlus:33 The pancreas is a large gland behind the stomach and close to the first part of the small intestine. it secretes digestive juices into the small intestine through a tube called the pancreatic duct. the pancreas also releases the hormones insulin and glucagon into the bloodstream. pancreatitis is inflammation of the pancreas. it happens when digestive enzymes start digesting the pancreas itself. pancreatitis can be acute or chronic. either form is serious and can lead to complications. acute pancreatitis occurs suddenly and usually goes away in a few days with treatment. it is often caused by gallstones. common symptoms are severe pain in the upper abdomen, nausea, and vomiting. treatment is usually a few days in the hospital for intravenous (iv) fluids, antibiotics, and medicines to relieve pain. chronic pancreatitis does not heal or improve. it gets worse over time and leads to permanent damage. the most common cause is heavy alcohol use. other causes include cystic fibrosis and other inherited disorders, high levels of calcium or fats in the blood, some medicines, and autoimmune conditions. symptoms include nausea, vomiting, weight loss, and oily stools. treatment may also be a few days in the hospital for intravenous (iv) fluids, medicines to relieve pain, and nutritional support. after that, you may need to start taking enzymes and eat a special diet. it is also important to not smoke or drink alcohol. nih: national institute of diabetes, digestive and kidney diseases

MalaCards: Pancreatitis, also known as pancreatitis nos, is related to pancreatic cancer and acute pancreatitis. An important gene associated with Pancreatitis is SMAD4 (SMAD family member 4), and among its related pathways are Pancreatic secretion and Lipoprotein metabolism. The drugs propantheline and propantheline bromide and the compounds calcium and glucose have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, pancreas and liver, and related mouse phenotypes are homeostasis/metabolism and digestive/alimentary.

Wikipedia:63 Pancreatitis is an inflammation of the pancreas. It has several causes and symptoms and requires... more...

GeneReviews summary for pancreatitis-ov

Aliases & Classifications for Pancreatitis

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Sources:
8Disease Ontology, 19GeneReviews, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreatitis 8 19 10 44 33 60
pancreatitis nos 8


External Ids:

Disease Ontology8 DOID:4989
MeSH34 D010195
NCIt39 C3306

Related Diseases for Pancreatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Pancreatitis, Chronic family:

Acute Pancreatitis pancreatitis
Autoimmune Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 923)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cancer32.1MUC4, RNASE1, SPINK1, SMAD4
2acute pancreatitis31.9REG3A, REG1A, CLPS, GP2, PNLIP, SPINK1
3adenocarcinoma31.8PDX1, SCTR, SMAD4, CEL, SPINK1, PNLIP
4alcoholic pancreatitis31.4SPINK1, CPB1
5exocrine pancreatic insufficiency31.3PPY, PNLIP, CELA3B, CEL, CELA1
6cystic fibrosis31.1SCTR, MUC4, REG3A, PNLIP, SPINK1, CELA3B
7diabetes mellitus31.1PDX1, PPY, REG1A, SPINK1
8pancreatic steatorrhea30.9CELA1, CELA3B, PNLIP
9insulinoma30.8PDX1, MAFA, REG3A, SMAD4
10steatorrhea30.8CLPS, PNLIP, CELA3B, CELA1
11adenoma30.8MUC4, REG1A, SPINK1, SMAD4
12obesity30.7CLPS, PNLIP
13gastrinoma30.5SMAD4, SCTR
14vipoma30.5SMAD4
15hereditary pancreatitis30.5SPINK1, REG1A
16pancreas disease30.3SMAD4, SPINK1, PNLIP, CLPS, REG1A, REG3A
17maturity-onset diabetes of the young30.2PDX1
18pancreatitis, chronic30.1MUC4, REG3A, REG1A, RNASE1, PNLIP, SPINK1
19esophageal cancer30.0MUC4, SPINK1, SMAD4
20tropical calcific pancreatitis29.8SPINK1
21stomach cancer29.5SMAD4, SPINK1, PNLIP, REG3A, MUC4
22pancreatic ductal adenocarcinoma11.1
23duodenitis10.8
24neuroendocrine tumor10.8
25islet cell tumor10.7
26hepatitis10.7
27pancreatic ductal carcinoma10.7
28pancreatic cystadenoma10.7
29cystadenoma10.7
30cholangitis10.6
31acinar cell carcinoma10.6
32panniculitis10.6
33obstructive jaundice10.6
34vascular cancer10.5
35pancreas adenocarcinoma10.5
36somatostatinoma10.5
37pancreatic serous cystadenoma10.5
38pancreatic somatostatinoma10.5
39von hippel-lindau disease10.5
40duodenal obstruction10.5
41pancreatic cystadenocarcinoma10.5
42pancreatic intraductal papillary-mucinous neoplasm10.5
43cystadenocarcinoma10.5
44choledochal cyst10.5
45sclerosing cholangitis10.4
46hypoglycemia10.4
47hepatitis a10.4
48pancreatic endocrine carcinoma10.4
49pancreatic cholera10.4
50peritonitis10.4

Graphical network of the top 20 diseases related to Pancreatitis:



Diseases related to pancreatitis

Clinical Features for Pancreatitis

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Drugs & Therapeutics for Pancreatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pancreatitis

Drug clinical trials:

Search ClinicalTrials for Pancreatitis

Search NIH Clinical Center for Pancreatitis

Search CenterWatch for Pancreatitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pancreatitis

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Anatomical Context for Pancreatitis

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32MalaCards
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MalaCards organs/tissues related to Pancreatitis:

32
Pancreatic islet, Pancreas, Liver, Testes, Endothelial, Lung, Small intestine, Kidney, Lymph node, T cells, Breast, Colon, Bone, B cells, Monocytes, Brain, Prostate, Pituitary, Spleen, Thyroid, Bone marrow, Heart, Ovary, Myeloid, Skin, Smooth muscle, Spinal cord, Adipocyte, Skeletal muscle, Salivary gland, Testis, Cortex, Adrenal cortex, Whole blood, Nk cells, Cervix, Thymus, Fetal liver

Animal Models for Pancreatitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pancreatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.9SMAD4, PDX1, SCTR, MAFA, REG3A, REG1A
2MP:000538111.9CLPS, PNLIP, SPINK1, CEL, SMAD4, PDX1

Publications for Pancreatitis

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Sources:
50PubMed
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Articles related to Pancreatitis:

(show top 50)    (show all 14047)
idTitleAuthorsYear
1
FOXM1 and its oncogenic signaling in pancreatic cancer pathogenesis. (24418574)
2014
2
Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through I+7nAChR-mediated MUC4 upregulation. (22614008)
2013
3
Abdominal compartment syndrome is an early, lethal complication of acute pancreatitis. (23711270)
2013
4
Pleiotrophin promotes perineural invasion in pancreatic cancer. (24151381)
2013
5
Resveratrol suppresses microcirculatory disturbance in a rat model of severe acute pancreatitis. (23546938)
2013
6
Endoscopic management of acute biliary pancreatitis. (24079788)
2013
7
Seropositivity to Helicobacter pylori and Risk of Pancreatic Cancer. (24089457)
2013
8
Targeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells. (24063415)
2013
9
The use of heparin in the treatment of acute pancreatitis. (23640932)
2013
10
Cannabis-induced acute pancreatitis. (23892868)
2013
11
Volume replacement with saline solutions during pancreatitis in rats and the hepatic profiles of apoptotic proteins and heat-shock proteins. (23917928)
2012
12
Global microRNA expression profiling of microdissected tissues identifies miR-135b as a novel biomarker for pancreatic ductal adenocarcinoma. (21953293)
2012
13
Targeting a novel onco-glycoprotein antigen at tumoral pancreatic cell surface by mAb16D10 induces cell death. (22956586)
2012
14
Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis. (21356084)
2011
15
A 41-Year-Old Man with Two Types of Metachronous Peptic Ulcer Complication due to Zollinger-Ellison Syndrome-Regression of Pancreatic Primary after Chemoembolization of Hepatic Metastases: A Case Report. (21811506)
2011
16
Mesothelin confers pancreatic cancer cell resistance to TNF-I+-induced apoptosis through Akt/PI3K/NF-I_B activation and IL-6/Mcl-1 overexpression. (21880146)
2011
17
Azathioprine induced pancreatitis in a patient with co-existing autoimmune pancreatitis and hepatitis. (21546702)
2011
18
Mathematical modelling of interferon-gamma signalling in pancreatic stellate cells reflects and predicts the dynamics of STAT1 pathway activity. (19781632)
2010
19
Severe acute pancreatitis due to tamoxifen-induced hypertriglyceridemia with positive rechallenge. (20601815)
2010
20
Diagnosis and treatment of autoimmune pancreatitis. (20693897)
2010
21
Transcriptional regulation of human mucin gene MUC4 in pancreatic cancer cells. (19757157)
2010
22
Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling. (20484029)
2010
23
14-3-3sigma Modulates pancreatic cancer cell survival and invasiveness. (19047086)
2008
24
Pancreatic perfusion: noninvasive quantitative assessment with dynamic contrast-enhanced MR imaging without and with secretin stimulation in healthy volunteers--initial results. (18292476)
2008
25
MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. (18381409)
2008
26
Preoperative localization of pancreatic insulinoma by super selective arterial stimulation with venous sampling. (16932851)
2007
27
Resistin-- a new laboratory marker useful in diagnosis of acute pancreatitis?]. (17679375)
2007
28
RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose. (17951542)
2007
29
Hsulf-1 regulates growth and invasion of pancreatic cancer cells. (16603650)
2006
30
Aberrant expression of neuropilin-1 and -2 in human pancreatic cancer cells. (14760080)
2004
31
Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives. (14745573)
2004
32
A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene. (12800145)
2003
33
Arsenic trioxide induces apoptosis in pancreatic cancer cells via changes in cell cycle, caspase activation, and GADD expression. (12883267)
2003
34
MEK inhibition of pancreatic carcinoma cells by U0126 and its effect in combination with sulindac. (14576498)
2003
35
Phase II trial of 5-fluorouracil plus eniluracil in patients with advanced pancreatic cancer: a Southwest Oncology Group study. (12377645)
2002
36
Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation. (11916914)
2002
37
Reduced membranous and ectopic cytoplasmic expression of beta -catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer. (11307154)
2001
38
Effects of synthetic serine protease inhibitors on proliferation and collagen synthesis of human pancreatic periacinar fibroblast-like cells. (11291936)
2001
39
Enhanced expression of Silencer of death domains (SODD/BAG-4) in pancreatic cancer. (10799310)
2000
40
High serum levels of Transforming Growth Factor-beta1, Interleukin-10 and Vascular Endothelial Growth Factor in pancreatic adenocarcinoma patients]. (16498312)
1999
41
Pancreatitis associated with pancreatic islet cell tumors. (10414710)
1999
42
Pancreatic cancer cells selectively stimulate islet beta cells to secrete amylin. (9428227)
1998
43
Cholecystokinin B-type receptor signaling is involved in human pancreatic cancer cell growth. (9574824)
1997
44
The hereditary pancreatitis gene maps to long arm of chromosome 7. (8845851)
1996
45
Case report: computed tomography features of complete splenic infarction, cavitation and spontaneous decompression complicating pancreatitis. (7627492)
1995
46
Duodenogastric reflux and pancreatic growth. (7615292)
1995
47
Induction and expression of heparin-binding EGF-like growth factor in human pancreatic cancer. (8060360)
1994
48
Enzyme immunoassay and characterization of pancreatic stone proteins in human urine. (8277359)
1993
49
Presence of glucagon-containing peptides in a human pancreatic glucagonoma and its liver metastasis. (1916643)
1991
50
Plasma proinsulin in patients with functioning pancreatic islet cell tumors. (4342038)
1972

Genetic Variations for Pancreatitis

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Expression for genes affiliated with Pancreatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatitis

Search GEO for disease gene expression data for Pancreatitis.

Pathways for genes affiliated with Pancreatitis

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29KEGG, 53Reactome
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Pathways related to Pancreatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.9CPA1, CPB1, CEL, CELA3B, PNLIP, SCTR
2
Hide members
11.2CLPS, PNLIP, CEL
311.2CLPS, PNLIP, CEL
411.2CLPS, PNLIP, CEL
511.2CPA1, CPB1, CELA3B

Compounds for genes affiliated with Pancreatitis

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Pancreatitis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2416.5PDX1, SCTR, MUC4, REG1A, REG1B, RNASE1
2glucose4412.5PDX1, MAFA, REG3A, REG1A, RNASE1, PNLIP
3serine4412.2PDX1, REG1A, RNASE1, PNLIP, SPINK1, CEL
4trypsinogen4411.8SPINK1, PNLIP, REG1A, REG3A
5oligonucleotide4411.7PDX1, MUC4, RNASE1, CEL, SMAD4
6orlistat44 59 1113.5CLPS, PNLIP, CEL
7nicotinamide44 1112.5REG1A, REG3A, PDX1
8triacylglycerol4411.4CLPS, PNLIP, CEL
9bicarbonate4411.3CEL, PNLIP, SCTR
10METHOXYUNDECYLPHOSPHINIC ACID1111.3PNLIP, CLPS
11(Hydroxyethyloxy)Tri(Ethyloxy)Octane1111.3PNLIP, CLPS
12p-nitrophenyl acetate4411.2PNLIP, CEL
13ethylenediamine4411.2RNASE1, CEL
14jzl 1845911.2CEL, PNLIP
15gsk 264220a5911.2CEL, PNLIP
16pristimerin5911.1CEL, PNLIP
17monoacylglycerol4411.0CEL, PNLIP
18paraoxon44 2411.9CEL, PNLIP
19h2o4410.7CLPS, RNASE1

GO Terms for genes affiliated with Pancreatitis

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16Gene Ontology
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Cellular components related to Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557613.6CPB1, REG1A, REG1B, REG3G, RNASE1, CLPS

Biological processes related to Pancreatitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1lipid digestionGO:04424111.4CEL, PNLIP, CLPS
2positive regulation of keratinocyte proliferationGO:01083811.1REG3G, REG3A
3negative regulation of keratinocyte differentiationGO:04561711.0REG3G, REG3A
4exocrine pancreas developmentGO:03101711.0PDX1, CELA1
5nitric oxide mediated signal transductionGO:00726311.0MAFA, PDX1
6intestinal cholesterol absorptionGO:03029910.9PNLIP, CEL
7positive regulation of wound healingGO:09030310.7REG3G, REG3A

Molecular functions related to Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:03024611.4REG3G, REG1B, REG1A, REG3A
2metallocarboxypeptidase activityGO:00418111.0CPA1, CPB1
3triglyceride lipase activityGO:00480610.7CEL, PNLIP

Products for genes affiliated with Pancreatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pancreatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet