MCID: PNC044
MIFTS: 58

Pancreatitis malady

Summaries for Pancreatitis

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 The pancreas is a large gland behind the stomach and close to the first part of the small intestine. it secretes digestive juices into the small intestine through a tube called the pancreatic duct. the pancreas also releases the hormones insulin and glucagon into the bloodstream. pancreatitis is inflammation of the pancreas. it happens when digestive enzymes start digesting the pancreas itself. pancreatitis can be acute or chronic. either form is serious and can lead to complications. acute pancreatitis occurs suddenly and usually goes away in a few days with treatment. it is often caused by gallstones. common symptoms are severe pain in the upper abdomen, nausea, and vomiting. treatment is usually a few days in the hospital for intravenous (iv) fluids, antibiotics, and medicines to relieve pain. chronic pancreatitis does not heal or improve. it gets worse over time and leads to permanent damage. the most common cause is heavy alcohol use. other causes include cystic fibrosis and other inherited disorders, high levels of calcium or fats in the blood, some medicines, and autoimmune conditions. symptoms include nausea, vomiting, weight loss, and oily stools. treatment may also be a few days in the hospital for intravenous (iv) fluids, medicines to relieve pain, and nutritional support. after that, you may need to start taking enzymes and eat a special diet. it is also important to not smoke or drink alcohol. nih: national institute of diabetes, digestive and kidney diseases

MalaCards: Pancreatitis, also known as pancreatitis nos, is related to acute pancreatitis and adenocarcinoma. An important gene associated with Pancreatitis is SMAD4 (SMAD family member 4), and among its related pathways are Pancreatic secretion and Lipoprotein metabolism. The drugs propantheline and propantheline bromide and the compounds calcium and glucose have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and digestive/alimentary.

Wikipedia:64 Pancreatitis is an inflammation of the pancreas. It has several causes and symptoms and requires... more...

Aliases & Classifications for Pancreatitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

pancreatitis 8 10 45 34 61
pancreatitis nos 8


External Ids:

Disease Ontology8 DOID:4989
MeSH35 D010195
NCIt40 C3306

Related Diseases for Pancreatitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the pancreatitis, chronic family:

acute pancreatitis pancreatitis
autoimmune pancreatitis autoimmune pancreatitis type 2
autoimmune pancreatitis type 1 recurrent acute pancreatitis

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 837)
idRelated DiseaseScoreTop Affiliating Genes
1acute pancreatitis32.0REG3A, REG1A, CLPS, GP2, PNLIP, SPINK1
2adenocarcinoma31.8PDX1, SCTR, SMAD4, CEL, SPINK1, PNLIP
3pancreatitis, chronic31.8MUC4, REG3A, REG1A, RNASE1, PNLIP, SPINK1
4alcoholic pancreatitis31.4SPINK1, CPB1
5exocrine pancreatic insufficiency31.4PPY, PNLIP, CELA3B, CEL, CELA1
6hereditary pancreatitis31.3SPINK1, REG1A
7cystic fibrosis31.1SCTR, MUC4, REG3A, PNLIP, SPINK1, CELA3B
8steatorrhea30.9CLPS, PNLIP, CELA3B, CELA1
9insulinoma30.9PDX1, MAFA, REG3A, SMAD4
10adenoma30.9MUC4, REG1A, SPINK1, SMAD4
11pancreatic steatorrhea30.9CELA1, CELA3B, PNLIP
12tropical calcific pancreatitis30.7SPINK1
13gastrinoma30.6SMAD4, SCTR
14vipoma30.5SMAD4
15stomach cancer29.5SMAD4, SPINK1, PNLIP, REG3A, MUC4
16autoimmune pancreatitis11.1
17recurrent acute pancreatitis10.8
18pancreatic ductal carcinoma10.7
19pancreatic endocrine tumors10.7
20cystadenoma10.7
21pancreatitis, idiopathic10.7
22pancreatic islet cell tumors10.6
23somatostatin analog10.6
24acinar cell carcinoma10.6
25hypoxia10.6
26hypertriglyceridemia10.6
27pancreatic adenoma10.6
28obstructive jaundice10.6
29fibrocalculous pancreatic diabetes10.6
30vascular cancer10.5
31pancreatic cancer 110.5
32n syndrome10.5
33pancreatic serous cystadenoma10.5
34pancreatic somatostatinoma10.5
35multiple endocrine neoplasia10.5
36somatostatinoma10.5
37pancreatic agenesis10.5
38choledochal cyst10.5
39sclerosing cholangitis10.5
40glucagonoma10.5
41hypoglycemia10.5
42pancreatic cholera10.5
43pancreatic endocrine carcinoma10.5
44chronic pain10.5
45cholera10.4
46hyperinsulinism10.4
47colorectal cancer10.4
48pancreatic mucinous cystadenoma10.4
49pancreatic gastrinoma10.4
50tuberculosis10.4

Graphical network of the top 20 diseases related to Pancreatitis:



Diseases related to pancreatitis

Clinical Features for Pancreatitis

Drugs & Therapeutics for Pancreatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pancreatitis

Drug clinical trials:

Search ClinicalTrials for Pancreatitis

Search NIH Clinical Center for Pancreatitis

Search CenterWatch for Pancreatitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Pancreatitis

Anatomical Context for Pancreatitis

Animal Models for Pancreatitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pancreatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.9SMAD4, PDX1, SCTR, MAFA, REG3A, REG1A
2MP:000538111.9CLPS, PNLIP, SPINK1, CEL, SMAD4, PDX1

Publications for Pancreatitis

Sources:
51PubMed
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Articles related to Pancreatitis:

(show top 50)    (show all 3819)
idTitleAuthorsYear
1
Association of oral glucocorticoid use with an increased risk of acute pancreatitis: a population-based nested case-control study. (23440105)
2013
2
New developments in diagnosis and non-surgical treatment of chronic pancreatitis. (24251715)
2013
3
Covered Self-expanding Metal Stents May be Preferable to Plastic Stents in the Treatment of Chronic Pancreatitis-related Biliary Strictures: A Systematic Review Comparing 2 Methods of Stent Therapy in Benign Biliary Strictures. (24275713)
2013
4
An evidence-based proposal for predicting organ failure in severe acute pancreatitis. (24152952)
2013
5
The role of Fas expression on the occurrence of immunosuppression in severe acute pancreatitis. (23861115)
2013
6
Acute pancreatitis and acute respiratory distress syndrome complicating Plasmodium vivax malaria. (23995320)
2013
7
Clinical profile and outcome of chronic pancreatitis in children. (23798627)
2013
8
Acute pancreatitis in pregnancy: review of three cases and anaesthetic management. (22959261)
2012
9
Triglyceride levels and apolipoprotein E polymorphism in patients with acute pancreatitis. (22251476)
2012
10
A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis. (22536085)
2012
11
Tropical calcific pancreatitis. (22446928)
2012
12
Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis? (22228370)
2012
13
Management of severe acute pancreatitis. (23372306)
2012
14
Prebiotics and low dose synbiotics for severe acute pancreatitis: time for a reappraisal? (23175934)
2012
15
Autoimmune pancreatitis. A rare cause of cholestasis. (20188640)
2011
16
MRI and S-MRCP findings in patients with suspected chronic pancreatitis: correlation with endoscopic pancreatic function testing (ePFT). (20187202)
2010
17
Anomalous pancreaticobiliary ductal union in tropical calcific pancreatitis. (20065547)
2010
18
IgG4 immunostaining of duodenal papillary biopsy specimens may be useful for supporting a diagnosis of autoimmune pancreatitis. (20304394)
2010
19
Mutational analysis of the gene encoding the zymogen granule membrane glycoprotein 2 (GP2) in patients with chronic pancreatitis. (19959969)
2010
20
Evaluation of duct-cell and acinar-cell function and endosonographic abnormalities in patients with suspected chronic pancreatitis. (18955165)
2009
21
Diagnosis of chronic pancreatitis by using apparent diffusion coefficient measurements at 3.0-T MR following secretin stimulation. (19508986)
2009
22
Heparin and insulin for hypertriglyceridemia-induced pancreatitis: case report. (19882092)
2009
23
Autoimmune pancreatitis: CT patterns and their changes after steroid treatment. (18430876)
2008
24
Eruptive xanthomas and acute pancreatitis in a patient with hypertriglyceridemia. (18474088)
2008
25
Life-threatening acute pancreatitis due to thalidomide therapy for chronic graft-versus-host disease. (18040684)
2008
26
Diabetes mellitus in patients with autoimmune pancreatitis: an often overlooked complication. (18656607)
2008
27
Alcoholic pancreatitis: mechanisms of viral infections as cofactors in the development of acute and chronic pancreatitis and fibrosis. (17095612)
2007
28
Effects of Salvia miltiorrhiza on serum levels of inflammatory cytokines in patients with severe acute pancreatitis]. (17214932)
2007
29
Expression of transforming growth factor beta by small duct epithelium in chronic, cancer-associated, obstructive pancreatitis: an in situ hybridization study and review of the literature. (18090242)
2007
30
Neutrophils from acute pancreatitis patients cause more severe in vitro endothelial damage compared with neutrophils from healthy donors and are differently regulated by endothelins. (17575543)
2007
31
Comparison of endoscopic ultrasound chronic pancreatitis criteria to the endoscopic secretin-stimulated pancreatic function test. (17387611)
2007
32
The effects of oral pancreatic enzymes (Creon 10 capsule) on steatorrhea: a multicenter, placebo-controlled, parallel group trial in subjects with chronic pancreatitis. (16868481)
2006
33
Acute pancreatitis associated with neuroendocrine tumor of the pancreas. (16407620)
2006
34
The effects of melatonin and pentoxiphylline on L-arginine induced acute pancreatitis]. (15877240)
2005
35
Soluble CD14 receptor expression and monocyte heterogeneity but not the C-260T CD14 genotype are associated with severe acute pancreatitis. (15599151)
2004
36
Expression of cancer testis antigens in pancreatic carcinoma cell lines, pancreatic adenocarcinoma and chronic pancreatitis. (14991579)
2004
37
CD56-positive cells with or without synaptophysin expression are recognized in the pancreatic duct epithelium: a study with adult and fetal tissues and specimens from chronic pancreatitis. (14726964)
2003
38
Chronic pancreatitis. (17033333)
2002
39
Identification of disease-specific genes in chronic pancreatitis using DNA array technology. (11729383)
2001
40
Evidence that diabetes mellitus favors impaired metabolism of zinc, copper, and selenium in chronic pancreatitis. (11291933)
2001
41
Outcome of surgical treatment of chronic pancreatitis associated with sphincter of Oddi dysfunction. (11379650)
2001
42
Evaluation of Ranson, Glasgow, APACHE-II, and APACHE-O criteria to predict severity in acute biliary pancreatitis. (11996072)
2001
43
Stricture of the main pancreatic duct due to focal pancreatitis coexistent with pancreatic cystadenoma. (10438172)
1999
44
Plasma cholecystokinin levels in acute pancreatitis. (9094154)
1997
45
Levels of leukocyte proteases in plasma and peritoneal exudate in severe, acute pancreatitis. (8047815)
1994
46
Effects of long-acting somatostatin analog (SMS 201-995) on eicosanoid synthesis and survival in rats with acute necrotizing pancreatitis. (1380426)
1992
47
Variations of the pancreatic ducts as a cause of chronic alcoholic pancreatitis. (2039013)
1991
48
Cimetidine in the treatment of acute alcoholic pancreatitis. A randomized, double-blind study. (381092)
1979
49
Management of mild and severe alcoholic pancreatitis. (238450)
1975
50
On lymphopenia in myocardial infarction and acute pancreatitis. (13361838)
1956

Genetic Variations for Pancreatitis

Expression for genes affiliated with Pancreatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pancreatitis

Search GEO for disease gene expression data for Pancreatitis.

Pathways for genes affiliated with Pancreatitis

Sources:
30KEGG, 54Reactome
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Pathways related to Pancreatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.9CPA1, CPB1, CEL, CELA3B, PNLIP, SCTR
2
Hide members
11.2CLPS, PNLIP, CEL
311.2CLPS, PNLIP, CEL
411.2CLPS, PNLIP, CEL
511.2CPA1, CPB1, CELA3B

Compounds for genes affiliated with Pancreatitis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Pancreatitis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2416.5PDX1, SCTR, MUC4, REG1A, REG1B, RNASE1
2glucose4512.5PDX1, MAFA, REG3A, REG1A, RNASE1, PNLIP
3serine4512.2PDX1, REG1A, RNASE1, PNLIP, SPINK1, CEL
4trypsinogen4511.8SPINK1, PNLIP, REG1A, REG3A
5oligonucleotide4511.7PDX1, MUC4, RNASE1, CEL, SMAD4
6orlistat45 60 1113.5CLPS, PNLIP, CEL
7nicotinamide45 1112.5REG1A, REG3A, PDX1
8triacylglycerol4511.4CLPS, PNLIP, CEL
9bicarbonate4511.3CEL, PNLIP, SCTR
10METHOXYUNDECYLPHOSPHINIC ACID1111.3PNLIP, CLPS
11(Hydroxyethyloxy)Tri(Ethyloxy)Octane1111.3PNLIP, CLPS
12p-nitrophenyl acetate4511.2PNLIP, CEL
13ethylenediamine4511.2RNASE1, CEL
14jzl 1846011.2CEL, PNLIP
15gsk 264220a6011.2CEL, PNLIP
16pristimerin6011.1CEL, PNLIP
17monoacylglycerol4511.0CEL, PNLIP
18paraoxon45 2411.9CEL, PNLIP
19h2o4510.7CLPS, RNASE1

GO Terms for genes affiliated with Pancreatitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557613.6CPB1, REG1A, REG1B, REG3G, RNASE1, CLPS

Biological processes related to Pancreatitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1lipid digestionGO:04424111.4CEL, PNLIP, CLPS
2positive regulation of keratinocyte proliferationGO:01083811.1REG3G, REG3A
3negative regulation of keratinocyte differentiationGO:04561711.0REG3G, REG3A
4exocrine pancreas developmentGO:03101711.0PDX1, CELA1
5nitric oxide mediated signal transductionGO:00726311.0MAFA, PDX1
6intestinal cholesterol absorptionGO:03029910.9PNLIP, CEL
7positive regulation of wound healingGO:09030310.7REG3G, REG3A

Molecular functions related to Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:03024611.4REG3G, REG1B, REG1A, REG3A
2metallocarboxypeptidase activityGO:00418111.0CPA1, CPB1
3triglyceride lipase activityGO:00480610.7CEL, PNLIP

Products for genes affiliated with Pancreatitis

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  • Lysates
  • Antibodies

Sources for Pancreatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet