MCID: PNC044
MIFTS: 69

Pancreatitis malady

Genetic diseases, Endocrine diseases, Gastrointestinal diseases, Rare diseases, Bone diseases, Immune diseases categories

Summaries for Pancreatitis

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35MedlinePlus, 66Wikipedia, 20GeneReviews, 34MalaCards
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MedlinePlus:35 The pancreas is a large gland behind the stomach and close to the first part of the small intestine. it secretes digestive juices into the small intestine through a tube called the pancreatic duct. the pancreas also releases the hormones insulin and glucagon into the bloodstream. pancreatitis is inflammation of the pancreas. it happens when digestive enzymes start digesting the pancreas itself. pancreatitis can be acute or chronic. either form is serious and can lead to complications. acute pancreatitis occurs suddenly and usually goes away in a few days with treatment. it is often caused by gallstones. common symptoms are severe pain in the upper abdomen, nausea, and vomiting. treatment is usually a few days in the hospital for intravenous (iv) fluids, antibiotics, and medicines to relieve pain. chronic pancreatitis does not heal or improve. it gets worse over time and leads to permanent damage. the most common cause is heavy alcohol use. other causes include cystic fibrosis and other inherited disorders, high levels of calcium or fats in the blood, some medicines, and autoimmune conditions. symptoms include nausea, vomiting, weight loss, and oily stools. treatment may also be a few days in the hospital for intravenous (iv) fluids, medicines to relieve pain, and nutritional support. after that, you may need to start taking enzymes and eat a special diet. it is also important to not smoke or drink alcohol. nih: national institute of diabetes, digestive and kidney diseases

MalaCards: Pancreatitis, also known as pancreatitis nos, is related to pancreatic cancer and adenocarcinoma. An important gene associated with Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are ethanol degradation II and Abacavir Pathway, Pharmacokinetics/Pharmacodynamics. The drugs propantheline and propantheline bromide and the compounds epft and h2dids have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, pancreas and liver, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Wikipedia:66 Pancreatitis is an inflammation of the pancreas. It has several causes and symptoms and requires... more...

GeneReviews summary for pancreatitis-ov

Aliases & Classifications for Pancreatitis

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9Disease Ontology, 20GeneReviews, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:



Aliases & Descriptions:

pancreatitis 9 20 11 46 35 63
pancreatitis nos 9


External Ids:

Disease Ontology9 DOID:4989
MeSH36 D010195
NCIt41 C3306

Related Diseases for Pancreatitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Hereditary Pancreatitis family:

Acute Pancreatitis pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Spink1-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Cftr-Related Hereditary Pancreatitis Pancreatitis, Chronic
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 990)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cancer32.3SCT, SPINK1, CCK
2adenocarcinoma31.7ALDH2, SPINK1, SCT, ADH1C, ADH1B, PRSS1
3hereditary pancreatitis31.4PRSS1, CTRC, SPINK1
4exocrine pancreatic insufficiency31.4CFTR, CCK, ELANE, SCT
5acute pancreatitis31.4ADH1C, REG3A, REG1A, LPL, CCK, ALDH2
6recurrent acute pancreatitis31.2LPL, SOD1, SPINK1, SCT, CFTR
7alcoholic pancreatitis31.2ADH1C, SPINK1, CFTR, CPB1, SCT, ALDH2
8cystic fibrosis31.1PRSS1, SPINK1, CFTR, SCT, ELANE, LPL
9diabetes mellitus31.0ALDH2, LPL, SOD1, SCT, APOC2, CCK
10tropical calcific pancreatitis30.9SPINK1
11steatorrhea30.9CCK, ELANE, TMPRSS15, SCT, CFTR
12glucagonoma30.9CCK, SCT
13adenoma30.9ADH1C, SCT, CTSB, SPINK1, REG1A
14cholera30.7CFTR, SCT, CCK
15hyperinsulinism30.7LPL, CCK, SCT
16hyperglycemia30.6LPL, CCK, SCT, SOD1
17duodenal ulcer30.6CCK, SCT
18glucose intolerance30.5APOC2, LPL, ALDH2
19liver cirrhosis30.4ADH1B, ALDH2, ADH1C, SCT
20gallbladder disease30.4CCK, CFTR
21hepatocellular carcinoma30.3ELANE, REG1A, ALDH2, REG3A, ADH1B, SCT
22gastritis30.3SCT, CCK
23type 2 diabetes mellitus30.3ALDH2, SPINK1, CTSB, CCK, LPL, APOC2
24duodenogastric reflux30.2CCK
25alcohol abuse30.2ALDH2, ADH1C
26colorectal cancer30.1PRSS2, SPINK1, CTSB, ALDH2, CCK, LPL
27lung cancer30.1CTSB, ALDH2, CCK, LPL, ADH1C, SPINK1
28alcoholic liver cirrhosis30.1ALDH2, ADH1B, ADH1C, SOD1
29familial hypertriglyceridemia30.0LPL, APOC2
30morbid obesity30.0LPL, CCK
31pancreatitis, chronic30.0ELANE, TMPRSS15, CCK, LPL, REG1A, REG3A
32aspergillosis29.9ELANE
33rheumatoid arthritis29.9PRSS2, CTSB, LPL, ELANE, CFTR
34atrophic gastritis29.9SOD1, SCT
35pancreas disease29.8CCK, SPINK1, CFTR, SCT, TMPRSS15, ELANE
36alzheimer's disease29.8CTSB, ALDH2, CCK, REG1A, SOD1, ELANE
37coronary artery disease29.8APOC2, LPL, ADH1C
38fatty liver disease29.6ALDH2, LPL, SOD1
39vascular disease29.5LPL, ELANE, SOD1, APOC2
40pancreatic ductal adenocarcinoma11.1
41autoimmune pancreatitis11.1
42duodenitis10.8
43neuroendocrine tumor10.8
44hepatitis10.7
45endotheliitis10.7
46islet cell tumor10.7
47pancreatic endocrine tumors10.7
48cystadenoma10.7
49pancreatic islet cell tumors10.7
50pancreatic ductal carcinoma10.7

Graphical network of the top 20 diseases related to Pancreatitis:



Diseases related to pancreatitis

Symptoms for Pancreatitis

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Drugs & Therapeutics for Pancreatitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Pancreatitis

Drug clinical trials:

Search ClinicalTrials for Pancreatitis

Search NIH Clinical Center for Pancreatitis

Search CenterWatch for Pancreatitis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Pancreatitis

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Anatomical Context for Pancreatitis

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34MalaCards
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MalaCards organs/tissues related to Pancreatitis:

34
Pancreatic islet, Pancreas, Liver, Testes, Endothelial, Lung, Small intestine, Kidney, Lymph node, T cells, Breast, Colon, Bone, B cells, Monocytes, Brain, Prostate, Pituitary, Spleen, Thyroid, Bone marrow, Heart, Ovary, Myeloid, Skin, Smooth muscle, Adipocyte, Spinal cord, Skeletal muscle, Salivary gland, Testis, Adrenal cortex, Cortex, Whole blood, Nk cells, Thymus, Fetal liver, Cervix

Animal Models for Pancreatitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pancreatitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.9CFTR, SOD1, REG1A, CCK, CTSB, SPINK1
2MP:00053766.5CTSB, SPINK1, CFTR, SCT, TMPRSS15, SOD1

Publications for Pancreatitis

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53PubMed
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Articles related to Pancreatitis:

(show top 50)    (show all 13896)
idTitleAuthorsYear
1
Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cells. (24297612)
2014
2
Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors. (24025713)
2014
3
Perineural mast cells are specifically enriched in pancreatic neuritis and neuropathic pain in pancreatic cancer and chronic pancreatitis. (23555989)
2013
4
Early enteral nutrition is superior to delayed enteral nutrition for the prevention of infected necrosis and mortality in acute pancreatitis. (23508012)
2013
5
Serum immunoglobulin G4 associated with number and distribution of extrapancreatic lesions in type 1 autoimmune pancreatitis patients. (21929654)
2012
6
Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma? (22436573)
2012
7
Recurrent acute pancreatitis in a patient on peritoneal dialysis using 7.5% icodextrin. (22991018)
2012
8
Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta. (21700708)
2011
9
Transthyretin, identified by proteomics, is overabundant in pancreatic juice from pancreatic carcinoma and originates from pancreatic islets. (20949480)
2011
10
Polyarthritis with chondronecrosis associated with osteonecrosis, panniculitis and pancreatitis. (19575201)
2010
11
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
12
Education and imaging. Hepatobiliary and pancreatic: Epithelioid hemangioendothelioma. (19335787)
2009
13
Panniculitis in a patient presenting with a pancreatic tumour and polyarthritis: a case report. (19830189)
2009
14
Enhanced antitumor effect of combined gemcitabine and proton radiation in the treatment of pancreatic cancer. (19506533)
2009
15
Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth. (19610136)
2009
16
Protective effect of lycopene on oxidative stress-induced cell death of pancreatic acinar cells. (19723106)
2009
17
Fucosylated haptoglobin is a novel marker for pancreatic cancer: detailed analyses of oligosaccharide structures. (18646007)
2008
18
Pancreatic laceration and portal vein thrombosis in blunt trauma abdomen. (20011472)
2008
19
Evaluation of topoisomerase IIa expression in pancreatic ductal adenocarcinoma: a pilot study using chromogenic in situ hybridization and immunohistochemistry on tissue microarrays. (17449965)
2007
20
Expression of heparanase and nuclear factor kappa B in pancreatic adenocarcinoma]. (17715045)
2007
21
Role of BRCA1 and BRCA2 mutations in pancreatic cancer. (16973716)
2007
22
DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients. (17914106)
2007
23
Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression. (17116388)
2007
24
N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption. (16705170)
2006
25
Recurrent acute pancreatitis in a patient with type IIb hyperlipoproteinemia: a case report and review of the literature in Korea. (16502498)
2006
26
Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer. (16865243)
2006
27
Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. (16568310)
2006
28
Extracellular matrix-mediated membrane-type 1 matrix metalloproteinase expression in pancreatic ductal cells is regulated by transforming growth factor-beta1. (16849548)
2006
29
Hereditary pancreatitis and secondary screening for early pancreatic cancer. (16358943)
2005
30
Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation. (14565847)
2004
31
Anti-cytokine therapy for severe acute pancreatitis]. (15552897)
2004
32
Gene therapy of pancreatic cancer with green fluorescent protein and tumor necrosis factor-related apoptosis-inducing ligand fusion gene expression driven by a human telomerase reverse transcriptase promoter. (12900367)
2003
33
BRCA2 germline mutations in familial pancreatic carcinoma. (12569143)
2003
34
Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma. (12843152)
2003
35
Laser microdissection of small tissue samples--application to chronic pancreatitis tissues. (12924436)
2003
36
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. (12235117)
2002
37
Detection of choledocholithiasis by EUS in acute pancreatitis: a prospective evaluation in 100 consecutive patients. (11522972)
2001
38
Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells. (10996854)
2000
39
Control of pancreatic bile-salt-dependent-lipase secretion by the glucose-regulated protein of 94 kDa (Grp94). (11104697)
2000
40
The POU domain transcription factor Tst-1 activates somatostatin receptor 1 gene expression in pancreatic beta -cells. (10866997)
2000
41
Diagnosis of lipid malabsorption in patients with chronic pancreatitis: a new indirect test using postprandial plasma apolipoprotein B-48. (10566720)
1999
42
Imaging of neuroendocrine gastro-entero-pancreatic tumours using radiolabelled somatostatin analogues. (10604128)
1999
43
Intraductal secretin test is as useful as duodenal secretin test in assessing exocrine pancreatic function. (9073129)
1997
44
Enzymatic markers of gallstone-induced pancreatitis identified by ROC curve analysis, discriminant analysis, logistic regression, likelihood ratios, and information theory. (7536644)
1995
45
Pneumocystis carinii pneumonia complicating somatostatin therapy of Cushing's syndrome in a patient with metastatic pancreatic islet cell carcinoma and Zollinger-Ellison syndrome. (1672788)
1991
46
Renal-hepatic-pancreatic dysplasia and its variants. (1741971)
1991
47
Effects of cholecystokinin-receptor blockade on pancreatic and biliary function in healthy volunteers. (2019374)
1991
48
Electron microscopic and immunoelectron microscopic demonstration of pancreatic polypeptide cells in glucagonoma: colocalization of pancreatic peptide and glucagon in single secretory granules. (2537546)
1989
49
Indomethacin-responsive pancreatic cholera. (197410)
1977
50
Meconium ileus; with cystic pancreatic fibrosis and early pulmonary complications. (13422754)
1957

Variations for Pancreatitis

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Expression for genes affiliated with Pancreatitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatitis

Search GEO for disease gene expression data for Pancreatitis.

Pathways for genes affiliated with Pancreatitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 52PharmGKB, 54QIAGEN, 56Reactome, 31KEGG, 61Thomson Reuters
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Pathways related to Pancreatitis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
acetate conversion to acetyl-CoA39
oxidative ethanol degradation III39
ethanol degradation IV39
10.0ALDH2, ADH1B
29.9ADH1B, ADH1C
3
Show member pathways
9.8ELANE, PRSS2, PRSS1
49.7CPB1, PRSS1, PRSS2
5
Show member pathways
9.6ALDH2, ADH1B, ADH1C
6
Show member pathways
mitochondrial L-carnitine shuttle pathway39
Saturated fatty acid biosynthesis61
9.6ALDH2, ADH1B, ADH1C
7
Show member pathways
9.6ALDH2, ADH1B, ADH1C
8
Show member pathways
glycolysis39
gluconeogenesis39
Glycolysis and Gluconeogenesis39
9.6ALDH2, ADH1B, ADH1C
9
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
9.6ADH1C, ADH1B, ALDH2
10
Show member pathways
9.6PRSS1, PRSS2, ELANE, CTSB
119.5PRSS2, PRSS1, CPB1, CFTR

Compounds for genes affiliated with Pancreatitis

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Sources:
46Novoseek, 25HMDB, 30IUPHAR, 12DrugBank, 3BitterDB, 62Tocris Bioscience, 52PharmGKB
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Compounds related to Pancreatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1epft4610.4SCT, CCK
2h2dids4610.3SCT, CFTR
3trioleoylglycerol4610.1APOC2, LPL
4taurodeoxycholate4610.1CCK, SCT
5betaine aldehyde46 2511.1ADH1C, ALDH2, ADH1B
6l-bpa4610.1CCK, SCT
73a,7a-Dihydroxy-5b-cholestan-26-al2510.0ADH1B, ALDH2, ADH1C
8carbachol46 30 1212.0CFTR, SCT, CCK, CTSB
9biotin46 25 1212.0SCT, LPL, CTSB, CFTR
10cerulein469.9SCT, ELANE, CCK, CTSB
11saccharin46 310.9CCK, ELANE
12ibmx46 62 3011.9CCK, LPL, SCT, CFTR
13rsai469.9ALDH2, ADH1C, ADH1B, APOC2
14aprotinin46 1210.9TMPRSS15, PRSS1, ELANE, CTSB
15nitroglycerin46 1210.9ELANE, SOD1, ALDH2
16probucol46 1210.9LPL, REG3A, SOD1
17acetaldehyde30 46 2511.8ALDH2, ADH1C, ADH1B
18caffeine46 30 3 52 25 1214.8CFTR, ELANE, CCK, LPL
19taurocholate469.8CCK, LPL, TMPRSS15, CFTR, SCT
20thyroxine46 2510.8SCT, LPL, CTSB, ELANE
21sodium nitroprusside469.8CCK, ALDH2, SOD1, ELANE
22carbon469.7CTSB, LPL, ELANE, CCK
23valine469.7CTSB, LPL, CFTR, ELANE
24alpha tocopherol469.7ELANE, LPL, ALDH2, SOD1
25isoproterenol46 1210.7SCT, ELANE, LPL, CTSB, CFTR
26indomethacin46 30 62 1212.7CTSB, CFTR, SCT, SOD1, LPL
27norepinephrine46 25 1211.6CCK, CFTR, LPL, SCT, ELANE
28acetylcholine46 52 30 25 1213.6LPL, SCT, CCK, ELANE, CFTR
29glycerol46 25 1211.6ADH1C, ADH1B, LPL, CCK, CFTR
30dopamine46 30 25 1212.6ALDH2, CCK, CFTR, SCT, ADH1B
31ethanol46 52 25 1212.6ADH1C, SCT, ADH1B, ALDH2, CTSB
32creatinine469.5ALDH2, SOD1, APOC2, CTSB, SPINK1
33polyacrylamide469.5ALDH2, APOC2, ADH1B, CTSB
34cyclosporin a46 30 6211.4LPL, CCK, CTSB, ELANE, CFTR, SCT
35pge2469.4CCK, SCT, CTSB, CFTR, ELANE, LPL
36nadph46 2510.4CTSB, ALDH2, ADH1B, ADH1C, SOD1
37lysine469.4APOC2, TMPRSS15, CPB1, ALDH2, SCT
38heparin46 30 25 1212.3TMPRSS15, ELANE, LPL, APOC2, CTSB
39retinoic acid46 2510.3ELANE, ALDH2, CCK, APOC2, SCT, CFTR
40glutamine469.2SCT, CFTR, CTSB, LPL, CCK, ALDH2
41vitamin a46 25 1211.0APOC2, ADH1B, ALDH2, SOD1, ADH1C, ELANE
42zinc46 2510.0SCT, CPB1, SOD1, ADH1C, CTSB, ADH1B
43adenylate469.0CFTR, LPL, CCK, SCT, ELANE
44glutamate468.9CCK, CFTR, SCT, SOD1, ELANE, LPL
45cysteine468.9ELANE, SCT, CTSB, ALDH2, PRSS2, PRSS1
46arginine468.8CTSB, SCT, ALDH2, TMPRSS15, CCK, PRSS1
47calcium46 52 25 1211.6CCK, CTRC, CTSB, PRSS2, REG1A, PRSS1
48glucose468.4SCT, ALDH2, REG1A, CCK, CTSB, LPL
49serine468.3CTSB, CTRC, ELANE, PRSS2, PRSS1, TMPRSS15
50trypsinogen467.8TMPRSS15, SCT, PRSS1, PRSS2, ELANE, REG3A

GO Terms for genes affiliated with Pancreatitis

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17Gene Ontology
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Cellular components related to Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:0426279.9LPL, APOC2
2very-low-density lipoprotein particleGO:0343619.7APOC2, LPL
3extracellular matrixGO:0310129.7LPL, PRSS2, SOD1
4extracellular spaceGO:0056158.7APOC2, SOD1, PRSS2, REG3A, LPL, CCK
5extracellular regionGO:0055766.9CTSB, SPINK1, SCT, APOC2, CPB1, SOD1

Biological processes related to Pancreatitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1chylomicron remodelingGO:03437110.3LPL, APOC2
2very-low-density lipoprotein particle remodelingGO:03437210.2LPL, APOC2
3triglyceride homeostasisGO:07032810.0LPL, APOC2
4ethanol oxidationGO:0060699.9ALDH2, ADH1B, ADH1C
5positive regulation of keratinocyte proliferationGO:0108389.9REG3G, REG3A
6collagen catabolic processGO:0305749.9PRSS2, ELANE, CTSB
7negative regulation of keratinocyte differentiationGO:0456179.9REG3G, REG3A
8extracellular matrix disassemblyGO:0226179.8PRSS1, PRSS2, ELANE, CTSB
9proteolysisGO:0065089.8PRSS2, ELANE, CTRC, CTSB
10positive regulation of wound healingGO:0903039.7REG3G, REG3A
11response to drugGO:0424939.6LPL, SOD1, APOC2, CFTR
12extracellular matrix organizationGO:0301989.6PRSS1, PRSS2, ELANE, CTSB
13xenobiotic metabolic processGO:0068059.3ALDH2, ADH1B, ADH1C
14small molecule metabolic processGO:0442818.9APOC2, ADH1C, ADH1B, PRSS1, LPL, ALDH2

Molecular functions related to Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:0082339.4ELANE, CTRC, CTSB
2serine-type endopeptidase activityGO:0042529.2CTRC, ELANE, PRSS2, PRSS1, TMPRSS15
3carbohydrate bindingGO:0302469.2REG1A, REG3G, REG3A

Products for genes affiliated with Pancreatitis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Pancreatitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet