MCID: PNC044
MIFTS: 59

Pancreatitis malady

Genetic diseases, Endocrine diseases, Rare diseases, Gastrointestinal diseases, Skin diseases, Bone diseases, Immune diseases categories

Summaries for Pancreatitis

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MedlinePlus:32 The pancreas is a large gland behind the stomach and close to the first part of the small intestine. it secretes digestive juices into the small intestine through a tube called the pancreatic duct. the pancreas also releases the hormones insulin and glucagon into the bloodstream. pancreatitis is inflammation of the pancreas. it happens when digestive enzymes start digesting the pancreas itself. pancreatitis can be acute or chronic. either form is serious and can lead to complications. acute pancreatitis occurs suddenly and usually goes away in a few days with treatment. it is often caused by gallstones. common symptoms are severe pain in the upper abdomen, nausea, and vomiting. treatment is usually a few days in the hospital for intravenous (iv) fluids, antibiotics, and medicines to relieve pain. chronic pancreatitis does not heal or improve. it gets worse over time and leads to permanent damage. the most common cause is heavy alcohol use. other causes include cystic fibrosis and other inherited disorders, high levels of calcium or fats in the blood, some medicines, and autoimmune conditions. symptoms include nausea, vomiting, weight loss, and oily stools. treatment may also be a few days in the hospital for intravenous (iv) fluids, medicines to relieve pain, and nutritional support. after that, you may need to start taking enzymes and eat a special diet. it is also important to not smoke or drink alcohol. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Pancreatitis is related to pancreatic cancer and tropical calcific pancreatitis. An important gene associated with Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are ethanol degradation II and Abacavir Pathway, Pharmacokinetics/Pharmacodynamics. The drugs propantheline and propantheline bromide and the compounds epft and h2dids have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, pancreas and liver, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Wikipedia:63 Pancreatitis is inflammation of the pancreas. The pancreas is a large organ behind the stomach which... more...

GeneReviews summary for pancreatitis-ov

Aliases & Classifications for Pancreatitis

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Pancreatitis, Aliases & Descriptions:

Name: Pancreatitis 9 19 11 43 32 60


Classifications:



External Ids:

Disease Ontology9 DOID:4989
NCIt38 C3306
MeSH33 D010195

Related Diseases for Pancreatitis

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Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Acute Pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Spink1-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Cftr-Related Hereditary Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1013)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cancer32.6CCK, SCT, SPINK1
2tropical calcific pancreatitis31.7SPINK1
3exocrine pancreatic insufficiency31.6CFTR, SCT, ELANE, CCK
4hypertriglyceridemia31.5APOC2, LPL
5pancreatitis, hereditary31.3SPINK1, PRSS1, CTRC
6recurrent acute pancreatitis31.3SPINK1, CFTR, SCT, SOD1, LPL
7glucagonoma31.3CCK, SCT
8adenocarcinoma31.1SPINK1, SCT, ADH1C, ADH1B, PRSS1, REG3A
9hyperinsulinism31.0CCK, LPL, SCT
10cholera31.0CFTR, SCT, CCK
11duodenal ulcer31.0SCT, CCK
12cystic fibrosis31.0SPINK1, CFTR, SCT, PRSS1, ELANE, REG3A
13steatorrhea30.9CFTR, SCT, TMPRSS15, ELANE, CCK
14adenoma30.9CTSB, REG1A, ADH1C, SCT, SPINK1
15gallbladder disease30.9CFTR, CCK
16duodenogastric reflux30.8CCK
17glucose intolerance30.8APOC2, LPL, ALDH2
18gastritis30.8CCK, SCT
19hyperglycemia30.8CCK, LPL, SOD1, SCT
20alcoholic pancreatitis30.6ELANE, CCK, ALDH2, ADH1B, ADH1C, CPB1
21liver cirrhosis30.5ALDH2, ADH1B, ADH1C, SCT
22aspergillosis30.4ELANE
23morbid obesity30.4LPL, CCK
24alcohol abuse30.4ALDH2, ADH1C
25biliary dyskinesia30.3CCK
26atrophic gastritis30.2SOD1, SCT
27hepatocellular carcinoma30.1SPINK1, SCT, ADH1B, ELANE, REG3A, REG1A
28alcoholic liver cirrhosis30.1ALDH2, ADH1B, ADH1C, SOD1
29tongue squamous cell carcinoma30.1ADH1B, ALDH2
30coronary artery disease29.9APOC2, ADH1C, LPL
31rheumatoid arthritis29.8CFTR, PRSS2, ELANE, LPL, CTSB
32lung cancer29.8SPINK1, CFTR, ADH1C, LPL, CCK, ALDH2
33fatty liver disease29.7ALDH2, LPL, SOD1
34acute pancreatitis29.7SPINK1, CFTR, SCT, APOC2, TMPRSS15, CPB1
35diabetes mellitus, insulin-dependent29.7SPINK1, SCT, APOC2, SOD1, REG1A, LPL
36vascular disease29.6APOC2, SOD1, ELANE, LPL
37colorectal cancer29.5SPINK1, ADH1C, ADH1B, PRSS2, REG3A, REG1A
38pancreas disease29.5SPINK1, CFTR, SCT, TMPRSS15, ELANE, REG3A
39alzheimer disease29.1APOC2, SOD1, ELANE, REG1A, CCK, ALDH2
40pancreatic ductal adenocarcinoma11.1
41autoimmune pancreatitis11.1
42duodenitis10.9
43neuroendocrine tumor10.8
44hepatitis10.8
45endotheliitis10.8
46islet cell tumor10.8
47cystadenoma10.7
48pancreatic islet cell tumors10.7
49pancreatic ductal carcinoma10.7
50cholangitis10.7

Graphical network of the top 20 diseases related to Pancreatitis:



Diseases related to pancreatitis

Symptoms for Pancreatitis

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Drugs & Therapeutics for Pancreatitis

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Drug clinical trials:

Search ClinicalTrials for Pancreatitis

Search NIH Clinical Center for Pancreatitis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Pancreatitis

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Anatomical Context for Pancreatitis

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MalaCards organs/tissues related to Pancreatitis:

31
Pancreatic islet, Pancreas, Liver, Testes, Endothelial, Lung, Kidney, Lymph node, T cells, Breast, Colon, Small intestine, Neutrophil, Bone, Monocytes, B cells, Spleen, Brain, Prostate, Pituitary, Thyroid, Heart, Bone marrow, Ovary, Myeloid, Smooth muscle, Skin, Spinal cord, Adipocyte, Skeletal muscle, Salivary gland, Testis, Cortex, Adrenal cortex, Whole blood, Nk cells, Thymus, Uterus, Cervix, Fetal liver

Animal Models for Pancreatitis or affiliated genes

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MGI Mouse Phenotypes related to Pancreatitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.9SPINK1, CFTR, SOD1, REG1A, CCK, CTSB
2MP:00053766.5SPINK1, CFTR, SCT, TMPRSS15, SOD1, ADH1C

Publications for Pancreatitis

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Articles related to Pancreatitis:

(show top 50)    (show all 14515)
idTitleAuthorsYear
1
Acute fatty liver of pregnancy with hypoglycaemia, diabetes insipidus and pancreatitis, preceded by intrahepatic cholestasis of pregnancy. (25878236)
2015
2
Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cells. (24297612)
2014
3
Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors. (24025713)
2014
4
Coexisting pancreatic mucinous cyst adenoma and adrenal lymphangioma. (25224209)
2014
5
Perineural mast cells are specifically enriched in pancreatic neuritis and neuropathic pain in pancreatic cancer and chronic pancreatitis. (23555989)
2013
6
Early enteral nutrition is superior to delayed enteral nutrition for the prevention of infected necrosis and mortality in acute pancreatitis. (23508012)
2013
7
Serum immunoglobulin G4 associated with number and distribution of extrapancreatic lesions in type 1 autoimmune pancreatitis patients. (21929654)
2012
8
Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma? (22436573)
2012
9
Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta. (21700708)
2011
10
Transthyretin, identified by proteomics, is overabundant in pancreatic juice from pancreatic carcinoma and originates from pancreatic islets. (20949480)
2011
11
Polyarthritis with chondronecrosis associated with osteonecrosis, panniculitis and pancreatitis. (19575201)
2010
12
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
13
Education and imaging. Hepatobiliary and pancreatic: Epithelioid hemangioendothelioma. (19335787)
2009
14
Panniculitis in a patient presenting with a pancreatic tumour and polyarthritis: a case report. (19830189)
2009
15
Enhanced antitumor effect of combined gemcitabine and proton radiation in the treatment of pancreatic cancer. (19506533)
2009
16
Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth. (19610136)
2009
17
Protective effect of lycopene on oxidative stress-induced cell death of pancreatic acinar cells. (19723106)
2009
18
Obesity alters cytokine gene expression and promotes liver injury in rats with acute pancreatitis. (18223607)
2008
19
Fucosylated haptoglobin is a novel marker for pancreatic cancer: detailed analyses of oligosaccharide structures. (18646007)
2008
20
Pancreatic laceration and portal vein thrombosis in blunt trauma abdomen. (20011472)
2008
21
Evaluation of topoisomerase IIa expression in pancreatic ductal adenocarcinoma: a pilot study using chromogenic in situ hybridization and immunohistochemistry on tissue microarrays. (17449965)
2007
22
Expression of heparanase and nuclear factor kappa B in pancreatic adenocarcinoma]. (17715045)
2007
23
Role of BRCA1 and BRCA2 mutations in pancreatic cancer. (16973716)
2007
24
DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients. (17914106)
2007
25
Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression. (17116388)
2007
26
N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption. (16705170)
2006
27
Recurrent acute pancreatitis in a patient with type IIb hyperlipoproteinemia: a case report and review of the literature in Korea. (16502498)
2006
28
Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer. (16865243)
2006
29
Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. (16568310)
2006
30
Hereditary pancreatitis and secondary screening for early pancreatic cancer. (16358943)
2005
31
Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation. (14565847)
2004
32
Anti-cytokine therapy for severe acute pancreatitis]. (15552897)
2004
33
Gene therapy of pancreatic cancer with green fluorescent protein and tumor necrosis factor-related apoptosis-inducing ligand fusion gene expression driven by a human telomerase reverse transcriptase promoter. (12900367)
2003
34
BRCA2 germline mutations in familial pancreatic carcinoma. (12569143)
2003
35
Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma. (12843152)
2003
36
Laser microdissection of small tissue samples--application to chronic pancreatitis tissues. (12924436)
2003
37
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. (12235117)
2002
38
Detection of choledocholithiasis by EUS in acute pancreatitis: a prospective evaluation in 100 consecutive patients. (11522972)
2001
39
Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells. (10996854)
2000
40
Control of pancreatic bile-salt-dependent-lipase secretion by the glucose-regulated protein of 94 kDa (Grp94). (11104697)
2000
41
Diagnosis of lipid malabsorption in patients with chronic pancreatitis: a new indirect test using postprandial plasma apolipoprotein B-48. (10566720)
1999
42
Imaging of neuroendocrine gastro-entero-pancreatic tumours using radiolabelled somatostatin analogues. (10604128)
1999
43
Intraductal secretin test is as useful as duodenal secretin test in assessing exocrine pancreatic function. (9073129)
1997
44
Enzymatic markers of gallstone-induced pancreatitis identified by ROC curve analysis, discriminant analysis, logistic regression, likelihood ratios, and information theory. (7536644)
1995
45
Pneumocystis carinii pneumonia complicating somatostatin therapy of Cushing's syndrome in a patient with metastatic pancreatic islet cell carcinoma and Zollinger-Ellison syndrome. (1672788)
1991
46
Renal-hepatic-pancreatic dysplasia and its variants. (1741971)
1991
47
Effects of cholecystokinin-receptor blockade on pancreatic and biliary function in healthy volunteers. (2019374)
1991
48
Electron microscopic and immunoelectron microscopic demonstration of pancreatic polypeptide cells in glucagonoma: colocalization of pancreatic peptide and glucagon in single secretory granules. (2537546)
1989
49
Indomethacin-responsive pancreatic cholera. (197410)
1977
50
Meconium ileus; with cystic pancreatic fibrosis and early pulmonary complications. (13422754)
1957

Variations for Pancreatitis

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Expression for genes affiliated with Pancreatitis

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Search GEO for disease gene expression data for Pancreatitis.

Pathways for genes affiliated with Pancreatitis

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Pathways related to Pancreatitis according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
acetate conversion to acetyl-CoA36
oxidative ethanol degradation III36
ethanol degradation IV36
10.0ALDH2, ADH1B
29.9ADH1B, ADH1C
3
Show member pathways
9.8PRSS2, ELANE, PRSS1
49.7CPB1, PRSS1, PRSS2
5
Show member pathways
9.6ADH1C, ALDH2, ADH1B
6
Show member pathways
9.6ADH1C, ALDH2, ADH1B
7
Show member pathways
mitochondrial L-carnitine shuttle pathway36
Saturated fatty acid biosynthesis58
9.6ADH1C, ADH1B, ALDH2
8
Show member pathways
phenylalanine utilization36
noradrenaline and adrenaline degradation36
phenylalanine degradation IV36
9.6ADH1C, ADH1B, ALDH2
9
Show member pathways
glycolysis36
gluconeogenesis36
Glycolysis and Gluconeogenesis36
9.6ADH1C, ADH1B, ALDH2
10
Show member pathways
9.6ELANE, PRSS1, PRSS2, CTSB
119.5PRSS2, CFTR, CPB1, PRSS1

Compounds for genes affiliated with Pancreatitis

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Compounds related to Pancreatitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1epft4310.4SCT, CCK
2h2dids4310.3SCT, CFTR
3trioleoylglycerol4310.1APOC2, LPL
4taurodeoxycholate4310.1CCK, SCT
5betaine aldehyde43 2411.1ADH1C, ALDH2, ADH1B
6l-bpa4310.1CCK, SCT
7caerulein4310.1CCK, SCT
83a,7a-Dihydroxy-5b-cholestan-26-al2410.0ADH1B, ALDH2, ADH1C
9carbachol43 28 1212.0CFTR, SCT, CCK, CTSB
10biotin43 24 1212.0SCT, LPL, CTSB, CFTR
11cerulein439.9SCT, ELANE, CCK, CTSB
12ibmx43 59 2811.9CCK, LPL, SCT, CFTR
13rsai439.9ALDH2, ADH1C, ADH1B, APOC2
14aprotinin43 1210.9TMPRSS15, PRSS1, ELANE, CTSB
15nitroglycerin43 1210.9ELANE, SOD1, ALDH2
16probucol43 1210.9LPL, REG3A, SOD1
17acetaldehyde28 43 2411.8ALDH2, ADH1C, ADH1B
18caffeine43 28 2 49 24 1214.8CFTR, ELANE, CCK, LPL
19taurocholate439.8CCK, LPL, TMPRSS15, CFTR, SCT
20thyroxine43 2410.8SCT, LPL, CTSB, ELANE
21sodium nitroprusside439.8CCK, ALDH2, SOD1, ELANE
22carbon439.7CTSB, LPL, ELANE, CCK
23valine439.7CTSB, LPL, CFTR, ELANE
24alpha tocopherol439.7ELANE, LPL, ALDH2, SOD1
25isoproterenol43 1210.7SCT, ELANE, LPL, CTSB, CFTR
26indomethacin43 28 59 1212.7CTSB, CFTR, SCT, SOD1, LPL
27norepinephrine43 24 1211.6CCK, CFTR, LPL, SCT, ELANE
28acetylcholine43 49 28 24 1213.6LPL, SCT, CCK, ELANE, CFTR
29glycerol43 24 1211.6ADH1C, ADH1B, LPL, CCK, CFTR
30dopamine43 28 24 1212.6ALDH2, CCK, CFTR, SCT, ADH1B
31ethanol43 49 24 1212.6ADH1C, SCT, ADH1B, ALDH2, CTSB
32creatinine439.5ALDH2, SOD1, APOC2, CTSB, SPINK1
33polyacrylamide439.5ALDH2, APOC2, ADH1B, CTSB
34cyclosporin a43 28 5911.4LPL, CCK, CTSB, ELANE, CFTR, SCT
35pge2439.4CCK, SCT, CTSB, CFTR, ELANE, LPL
36nadph43 2410.4CTSB, ALDH2, ADH1B, ADH1C, SOD1
37lysine439.4APOC2, TMPRSS15, CPB1, ALDH2, SCT
38heparin43 28 24 1212.3TMPRSS15, ELANE, LPL, APOC2, CTSB
39retinoic acid43 2410.3ELANE, ALDH2, CCK, APOC2, SCT, CFTR
40glutamine439.2SCT, CFTR, CTSB, LPL, CCK, ALDH2
41vitamin a43 24 1211.0APOC2, ADH1B, ALDH2, SOD1, ADH1C, ELANE
42zinc43 2410.0SCT, CPB1, SOD1, ADH1C, CTSB, ADH1B
43adenylate439.0CFTR, LPL, CCK, SCT, ELANE
44glutamate438.9CCK, CFTR, SCT, SOD1, ELANE, LPL
45cysteine438.9ELANE, SCT, CTSB, ALDH2, PRSS2, PRSS1
46arginine438.8CTSB, SCT, ALDH2, TMPRSS15, CCK, PRSS1
47calcium43 49 24 1211.6CCK, CTRC, CTSB, PRSS2, REG1A, PRSS1
48glucose438.4SCT, ALDH2, REG1A, CCK, CTSB, LPL
49serine438.3CTSB, CTRC, ELANE, PRSS2, PRSS1, TMPRSS15
50trypsinogen437.8TMPRSS15, SCT, PRSS1, PRSS2, ELANE, REG3A

GO Terms for genes affiliated with Pancreatitis

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Cellular components related to Pancreatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:00426279.9LPL, APOC2
2very-low-density lipoprotein particleGO:00343619.7LPL, APOC2
3extracellular matrixGO:00310129.7PRSS2, LPL, SOD1
4extracellular spaceGO:00056158.7APOC2, SOD1, PRSS2, REG3A, LPL, CCK
5extracellular regionGO:00055766.9CTSB, SPINK1, SCT, APOC2, CPB1, SOD1

Biological processes related to Pancreatitis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1chylomicron remodelingGO:003437110.3LPL, APOC2
2very-low-density lipoprotein particle remodelingGO:003437210.2LPL, APOC2
3triglyceride homeostasisGO:007032810.0LPL, APOC2
4ethanol oxidationGO:00060699.9ALDH2, ADH1B, ADH1C
5positive regulation of keratinocyte proliferationGO:00108389.9REG3G, REG3A
6collagen catabolic processGO:00305749.9PRSS2, ELANE, CTSB
7negative regulation of keratinocyte differentiationGO:00456179.9REG3G, REG3A
8extracellular matrix disassemblyGO:00226179.8PRSS1, PRSS2, ELANE, CTSB
9proteolysisGO:00065089.8PRSS2, ELANE, CTRC, CTSB
10positive regulation of wound healingGO:00903039.7REG3G, REG3A
11response to drugGO:00424939.6LPL, SOD1, APOC2, CFTR
12extracellular matrix organizationGO:00301989.6PRSS1, PRSS2, ELANE, CTSB
13xenobiotic metabolic processGO:00068059.3ALDH2, ADH1B, ADH1C
14small molecule metabolic processGO:00442818.9APOC2, ADH1C, ADH1B, PRSS1, LPL, ALDH2

Molecular functions related to Pancreatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:00082339.4ELANE, CTRC, CTSB
2serine-type endopeptidase activityGO:00042529.2CTRC, ELANE, PRSS2, PRSS1, TMPRSS15
3carbohydrate bindingGO:00302469.2REG1A, REG3G, REG3A

Products for genes affiliated with Pancreatitis

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Sources for Pancreatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet