MCID: PNC044
MIFTS: 69

Pancreatitis malady

Genetic diseases, Endocrine diseases, Gastrointestinal diseases, Rare diseases, Bone diseases, Immune diseases categories
Download this MalaCard

Summaries for Pancreatitis

About this section
Sources:
34MedlinePlus, 65Wikipedia, 19GeneReviews, 33MalaCards
See all sources

Fully expand this MalaCard
MedlinePlus:34 The pancreas is a large gland behind the stomach and close to the first part of the small intestine. it secretes digestive juices into the small intestine through a tube called the pancreatic duct. the pancreas also releases the hormones insulin and glucagon into the bloodstream. pancreatitis is inflammation of the pancreas. it happens when digestive enzymes start digesting the pancreas itself. pancreatitis can be acute or chronic. either form is serious and can lead to complications. acute pancreatitis occurs suddenly and usually goes away in a few days with treatment. it is often caused by gallstones. common symptoms are severe pain in the upper abdomen, nausea, and vomiting. treatment is usually a few days in the hospital for intravenous (iv) fluids, antibiotics, and medicines to relieve pain. chronic pancreatitis does not heal or improve. it gets worse over time and leads to permanent damage. the most common cause is heavy alcohol use. other causes include cystic fibrosis and other inherited disorders, high levels of calcium or fats in the blood, some medicines, and autoimmune conditions. symptoms include nausea, vomiting, weight loss, and oily stools. treatment may also be a few days in the hospital for intravenous (iv) fluids, medicines to relieve pain, and nutritional support. after that, you may need to start taking enzymes and eat a special diet. it is also important to not smoke or drink alcohol. nih: national institute of diabetes, digestive and kidney diseases

MalaCards: Pancreatitis, also known as pancreatitis nos, is related to pancreatic cancer and adenocarcinoma. An important gene associated with Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are ethanol degradation II and Abacavir Pathway, Pharmacokinetics/Pharmacodynamics. The drugs propantheline and propantheline bromide and the compounds epft and h2dids have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, pancreas and liver, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Wikipedia:65 Pancreatitis is an inflammation of the pancreas. It has several causes and symptoms and requires... more...

GeneReviews summary for pancreatitis-ov

Aliases & Classifications for Pancreatitis

About this section
Sources:
8Disease Ontology, 19GeneReviews, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
See all sources

Classifications:



Aliases & Descriptions:

pancreatitis 8 19 10 45 34 62
pancreatitis nos 8


External Ids:

Disease Ontology8 DOID:4989
MeSH35 D010195
NCIt40 C3306

Related Diseases for Pancreatitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hereditary Pancreatitis family:

Acute Pancreatitis pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Spink1-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Cftr-Related Hereditary Pancreatitis Pancreatitis, Chronic
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 990)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cancer32.3SCT, SPINK1, CCK
2adenocarcinoma31.7ALDH2, SPINK1, SCT, ADH1C, ADH1B, PRSS1
3hereditary pancreatitis31.4PRSS1, CTRC, SPINK1
4exocrine pancreatic insufficiency31.4CFTR, CCK, ELANE, SCT
5acute pancreatitis31.4ADH1C, REG3A, REG1A, LPL, CCK, ALDH2
6recurrent acute pancreatitis31.2LPL, SOD1, SPINK1, SCT, CFTR
7alcoholic pancreatitis31.2ADH1C, SPINK1, CFTR, CPB1, SCT, ALDH2
8cystic fibrosis31.1PRSS1, SPINK1, CFTR, SCT, ELANE, LPL
9diabetes mellitus31.0ALDH2, LPL, SOD1, SCT, APOC2, CCK
10tropical calcific pancreatitis30.9SPINK1
11steatorrhea30.9CCK, ELANE, TMPRSS15, SCT, CFTR
12glucagonoma30.9CCK, SCT
13adenoma30.9ADH1C, SCT, CTSB, SPINK1, REG1A
14cholera30.7CFTR, SCT, CCK
15hyperinsulinism30.7LPL, CCK, SCT
16hyperglycemia30.6LPL, CCK, SCT, SOD1
17duodenal ulcer30.6CCK, SCT
18glucose intolerance30.5APOC2, LPL, ALDH2
19liver cirrhosis30.4ADH1B, ALDH2, ADH1C, SCT
20gallbladder disease30.4CCK, CFTR
21hepatocellular carcinoma30.3ELANE, REG1A, ALDH2, REG3A, ADH1B, SCT
22gastritis30.3SCT, CCK
23type 2 diabetes mellitus30.3ALDH2, SPINK1, CTSB, CCK, LPL, APOC2
24duodenogastric reflux30.2CCK
25alcohol abuse30.2ALDH2, ADH1C
26colorectal cancer30.1PRSS2, SPINK1, CTSB, ALDH2, CCK, LPL
27lung cancer30.1CTSB, ALDH2, CCK, LPL, ADH1C, SPINK1
28alcoholic liver cirrhosis30.1ALDH2, ADH1B, ADH1C, SOD1
29familial hypertriglyceridemia30.0LPL, APOC2
30morbid obesity30.0LPL, CCK
31pancreatitis, chronic30.0ELANE, TMPRSS15, CCK, LPL, REG1A, REG3A
32aspergillosis29.9ELANE
33rheumatoid arthritis29.9PRSS2, CTSB, LPL, ELANE, CFTR
34atrophic gastritis29.9SOD1, SCT
35pancreas disease29.8CCK, SPINK1, CFTR, SCT, TMPRSS15, ELANE
36alzheimer's disease29.8CTSB, ALDH2, CCK, REG1A, SOD1, ELANE
37coronary artery disease29.8APOC2, LPL, ADH1C
38fatty liver disease29.6ALDH2, LPL, SOD1
39vascular disease29.5LPL, ELANE, SOD1, APOC2
40pancreatic ductal adenocarcinoma11.1
41autoimmune pancreatitis11.1
42duodenitis10.8
43neuroendocrine tumor10.8
44hepatitis10.7
45endotheliitis10.7
46islet cell tumor10.7
47pancreatic endocrine tumors10.7
48cystadenoma10.7
49pancreatic islet cell tumors10.7
50pancreatic ductal carcinoma10.7

Graphical network of the top 20 diseases related to Pancreatitis:



Diseases related to pancreatitis

Symptoms for Pancreatitis

About this section

Drugs & Therapeutics for Pancreatitis

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Pancreatitis

Search NIH Clinical Center for Pancreatitis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Pancreatitis

About this section

Anatomical Context for Pancreatitis

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Pancreatitis:

33
Pancreatic islet, Pancreas, Liver, Testes, Endothelial, Lung, Small intestine, Kidney, Lymph node, T cells, Breast, Colon, Bone, B cells, Monocytes, Brain, Prostate, Pituitary, Spleen, Thyroid, Bone marrow, Heart, Ovary, Myeloid, Skin, Smooth muscle, Adipocyte, Spinal cord, Skeletal muscle, Salivary gland, Testis, Adrenal cortex, Cortex, Whole blood, Nk cells, Thymus, Fetal liver, Cervix

Animal Models for Pancreatitis or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Pancreatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.9CFTR, SOD1, REG1A, CCK, CTSB, SPINK1
2MP:00053766.5CTSB, SPINK1, CFTR, SCT, TMPRSS15, SOD1

Publications for Pancreatitis

About this section
Sources:
52PubMed
See all sources

Articles related to Pancreatitis:

(show top 50)    (show all 13896)
idTitleAuthorsYear
1
Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cells. (24297612)
2014
2
Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors. (24025713)
2014
3
Perineural mast cells are specifically enriched in pancreatic neuritis and neuropathic pain in pancreatic cancer and chronic pancreatitis. (23555989)
2013
4
Early enteral nutrition is superior to delayed enteral nutrition for the prevention of infected necrosis and mortality in acute pancreatitis. (23508012)
2013
5
Serum immunoglobulin G4 associated with number and distribution of extrapancreatic lesions in type 1 autoimmune pancreatitis patients. (21929654)
2012
6
Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma? (22436573)
2012
7
Recurrent acute pancreatitis in a patient on peritoneal dialysis using 7.5% icodextrin. (22991018)
2012
8
Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta. (21700708)
2011
9
Transthyretin, identified by proteomics, is overabundant in pancreatic juice from pancreatic carcinoma and originates from pancreatic islets. (20949480)
2011
10
Polyarthritis with chondronecrosis associated with osteonecrosis, panniculitis and pancreatitis. (19575201)
2010
11
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
12
Education and imaging. Hepatobiliary and pancreatic: Epithelioid hemangioendothelioma. (19335787)
2009
13
Panniculitis in a patient presenting with a pancreatic tumour and polyarthritis: a case report. (19830189)
2009
14
Enhanced antitumor effect of combined gemcitabine and proton radiation in the treatment of pancreatic cancer. (19506533)
2009
15
Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth. (19610136)
2009
16
Protective effect of lycopene on oxidative stress-induced cell death of pancreatic acinar cells. (19723106)
2009
17
Fucosylated haptoglobin is a novel marker for pancreatic cancer: detailed analyses of oligosaccharide structures. (18646007)
2008
18
Pancreatic laceration and portal vein thrombosis in blunt trauma abdomen. (20011472)
2008
19
Evaluation of topoisomerase IIa expression in pancreatic ductal adenocarcinoma: a pilot study using chromogenic in situ hybridization and immunohistochemistry on tissue microarrays. (17449965)
2007
20
Expression of heparanase and nuclear factor kappa B in pancreatic adenocarcinoma]. (17715045)
2007
21
Role of BRCA1 and BRCA2 mutations in pancreatic cancer. (16973716)
2007
22
DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients. (17914106)
2007
23
Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression. (17116388)
2007
24
N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption. (16705170)
2006
25
Recurrent acute pancreatitis in a patient with type IIb hyperlipoproteinemia: a case report and review of the literature in Korea. (16502498)
2006
26
Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer. (16865243)
2006
27
Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. (16568310)
2006
28
Extracellular matrix-mediated membrane-type 1 matrix metalloproteinase expression in pancreatic ductal cells is regulated by transforming growth factor-beta1. (16849548)
2006
29
Hereditary pancreatitis and secondary screening for early pancreatic cancer. (16358943)
2005
30
Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation. (14565847)
2004
31
Anti-cytokine therapy for severe acute pancreatitis]. (15552897)
2004
32
Gene therapy of pancreatic cancer with green fluorescent protein and tumor necrosis factor-related apoptosis-inducing ligand fusion gene expression driven by a human telomerase reverse transcriptase promoter. (12900367)
2003
33
BRCA2 germline mutations in familial pancreatic carcinoma. (12569143)
2003
34
Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma. (12843152)
2003
35
Laser microdissection of small tissue samples--application to chronic pancreatitis tissues. (12924436)
2003
36
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. (12235117)
2002
37
Detection of choledocholithiasis by EUS in acute pancreatitis: a prospective evaluation in 100 consecutive patients. (11522972)
2001
38
Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells. (10996854)
2000
39
Control of pancreatic bile-salt-dependent-lipase secretion by the glucose-regulated protein of 94 kDa (Grp94). (11104697)
2000
40
The POU domain transcription factor Tst-1 activates somatostatin receptor 1 gene expression in pancreatic beta -cells. (10866997)
2000
41
Diagnosis of lipid malabsorption in patients with chronic pancreatitis: a new indirect test using postprandial plasma apolipoprotein B-48. (10566720)
1999
42
Imaging of neuroendocrine gastro-entero-pancreatic tumours using radiolabelled somatostatin analogues. (10604128)
1999
43
Intraductal secretin test is as useful as duodenal secretin test in assessing exocrine pancreatic function. (9073129)
1997
44
Enzymatic markers of gallstone-induced pancreatitis identified by ROC curve analysis, discriminant analysis, logistic regression, likelihood ratios, and information theory. (7536644)
1995
45
Pneumocystis carinii pneumonia complicating somatostatin therapy of Cushing's syndrome in a patient with metastatic pancreatic islet cell carcinoma and Zollinger-Ellison syndrome. (1672788)
1991
46
Renal-hepatic-pancreatic dysplasia and its variants. (1741971)
1991
47
Effects of cholecystokinin-receptor blockade on pancreatic and biliary function in healthy volunteers. (2019374)
1991
48
Electron microscopic and immunoelectron microscopic demonstration of pancreatic polypeptide cells in glucagonoma: colocalization of pancreatic peptide and glucagon in single secretory granules. (2537546)
1989
49
Indomethacin-responsive pancreatic cholera. (197410)
1977
50
Meconium ileus; with cystic pancreatic fibrosis and early pulmonary complications. (13422754)
1957

Variations for Pancreatitis

About this section

Expression for genes affiliated with Pancreatitis

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pancreatitis

Search GEO for disease gene expression data for Pancreatitis.

Pathways for genes affiliated with Pancreatitis

About this section
Sources:
50PathCards, 38NCBI BioSystems Database, 51PharmGKB, 53QIAGEN, 55Reactome, 30KEGG, 60Thomson Reuters
See all sources

Pathways related to Pancreatitis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
acetate conversion to acetyl-CoA38
oxidative ethanol degradation III38
ethanol degradation IV38
10.0ALDH2, ADH1B
29.9ADH1B, ADH1C
3
Show member pathways
9.8ELANE, PRSS2, PRSS1
49.7CPB1, PRSS1, PRSS2
5
Show member pathways
9.6ALDH2, ADH1B, ADH1C
6
Show member pathways
mitochondrial L-carnitine shuttle pathway38
Saturated fatty acid biosynthesis60
9.6ALDH2, ADH1B, ADH1C
7
Show member pathways
9.6ALDH2, ADH1B, ADH1C
8
Show member pathways
glycolysis38
gluconeogenesis38
Glycolysis and Gluconeogenesis38
9.6ALDH2, ADH1B, ADH1C
9
Show member pathways
phenylalanine utilization38
noradrenaline and adrenaline degradation38
phenylalanine degradation IV38
9.6ADH1C, ADH1B, ALDH2
10
Show member pathways
9.6PRSS1, PRSS2, ELANE, CTSB
119.5PRSS2, PRSS1, CPB1, CFTR

Compounds for genes affiliated with Pancreatitis

About this section
Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 3BitterDB, 61Tocris Bioscience, 51PharmGKB
See all sources

Compounds related to Pancreatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1epft4510.4SCT, CCK
2h2dids4510.3SCT, CFTR
3trioleoylglycerol4510.1APOC2, LPL
4taurodeoxycholate4510.1CCK, SCT
5betaine aldehyde45 2411.1ADH1C, ALDH2, ADH1B
6l-bpa4510.1CCK, SCT
73a,7a-Dihydroxy-5b-cholestan-26-al2410.0ADH1B, ALDH2, ADH1C
8carbachol45 29 1112.0CFTR, SCT, CCK, CTSB
9biotin45 24 1112.0SCT, LPL, CTSB, CFTR
10cerulein459.9SCT, ELANE, CCK, CTSB
11saccharin45 310.9CCK, ELANE
12ibmx45 61 2911.9CCK, LPL, SCT, CFTR
13rsai459.9ALDH2, ADH1C, ADH1B, APOC2
14aprotinin45 1110.9TMPRSS15, PRSS1, ELANE, CTSB
15nitroglycerin45 1110.9ELANE, SOD1, ALDH2
16probucol45 1110.9LPL, REG3A, SOD1
17acetaldehyde29 45 2411.8ALDH2, ADH1C, ADH1B
18caffeine45 29 3 51 24 1114.8CFTR, ELANE, CCK, LPL
19taurocholate459.8CCK, LPL, TMPRSS15, CFTR, SCT
20thyroxine45 2410.8SCT, LPL, CTSB, ELANE
21sodium nitroprusside459.8CCK, ALDH2, SOD1, ELANE
22carbon459.7CTSB, LPL, ELANE, CCK
23valine459.7CTSB, LPL, CFTR, ELANE
24alpha tocopherol459.7ELANE, LPL, ALDH2, SOD1
25isoproterenol45 1110.7SCT, ELANE, LPL, CTSB, CFTR
26indomethacin45 29 61 1112.7CTSB, CFTR, SCT, SOD1, LPL
27norepinephrine45 24 1111.6CCK, CFTR, LPL, SCT, ELANE
28acetylcholine45 51 29 24 1113.6LPL, SCT, CCK, ELANE, CFTR
29glycerol45 24 1111.6ADH1C, ADH1B, LPL, CCK, CFTR
30dopamine45 29 24 1112.6ALDH2, CCK, CFTR, SCT, ADH1B
31ethanol45 51 24 1112.6ADH1C, SCT, ADH1B, ALDH2, CTSB
32creatinine459.5ALDH2, SOD1, APOC2, CTSB, SPINK1
33polyacrylamide459.5ALDH2, APOC2, ADH1B, CTSB
34cyclosporin a45 29 6111.4LPL, CCK, CTSB, ELANE, CFTR, SCT
35pge2459.4CCK, SCT, CTSB, CFTR, ELANE, LPL
36nadph45 2410.4CTSB, ALDH2, ADH1B, ADH1C, SOD1
37lysine459.4APOC2, TMPRSS15, CPB1, ALDH2, SCT
38heparin45 29 24 1112.3TMPRSS15, ELANE, LPL, APOC2, CTSB
39retinoic acid45 2410.3ELANE, ALDH2, CCK, APOC2, SCT, CFTR
40glutamine459.2SCT, CFTR, CTSB, LPL, CCK, ALDH2
41vitamin a45 24 1111.0APOC2, ADH1B, ALDH2, SOD1, ADH1C, ELANE
42zinc45 2410.0SCT, CPB1, SOD1, ADH1C, CTSB, ADH1B
43adenylate459.0CFTR, LPL, CCK, SCT, ELANE
44glutamate458.9CCK, CFTR, SCT, SOD1, ELANE, LPL
45cysteine458.9ELANE, SCT, CTSB, ALDH2, PRSS2, PRSS1
46arginine458.8CTSB, SCT, ALDH2, TMPRSS15, CCK, PRSS1
47calcium45 51 24 1111.6CCK, CTRC, CTSB, PRSS2, REG1A, PRSS1
48glucose458.4SCT, ALDH2, REG1A, CCK, CTSB, LPL
49serine458.3CTSB, CTRC, ELANE, PRSS2, PRSS1, TMPRSS15
50trypsinogen457.8TMPRSS15, SCT, PRSS1, PRSS2, ELANE, REG3A

GO Terms for genes affiliated with Pancreatitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:0426279.9LPL, APOC2
2very-low-density lipoprotein particleGO:0343619.7APOC2, LPL
3extracellular matrixGO:0310129.7LPL, PRSS2, SOD1
4extracellular spaceGO:0056158.7APOC2, SOD1, PRSS2, REG3A, LPL, CCK
5extracellular regionGO:0055766.9CTSB, SPINK1, SCT, APOC2, CPB1, SOD1

Biological processes related to Pancreatitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1chylomicron remodelingGO:03437110.3LPL, APOC2
2very-low-density lipoprotein particle remodelingGO:03437210.2LPL, APOC2
3triglyceride homeostasisGO:07032810.0LPL, APOC2
4ethanol oxidationGO:0060699.9ALDH2, ADH1B, ADH1C
5positive regulation of keratinocyte proliferationGO:0108389.9REG3G, REG3A
6collagen catabolic processGO:0305749.9PRSS2, ELANE, CTSB
7negative regulation of keratinocyte differentiationGO:0456179.9REG3G, REG3A
8extracellular matrix disassemblyGO:0226179.8PRSS1, PRSS2, ELANE, CTSB
9proteolysisGO:0065089.8PRSS2, ELANE, CTRC, CTSB
10positive regulation of wound healingGO:0903039.7REG3G, REG3A
11response to drugGO:0424939.6LPL, SOD1, APOC2, CFTR
12extracellular matrix organizationGO:0301989.6PRSS1, PRSS2, ELANE, CTSB
13xenobiotic metabolic processGO:0068059.3ALDH2, ADH1B, ADH1C
14small molecule metabolic processGO:0442818.9APOC2, ADH1C, ADH1B, PRSS1, LPL, ALDH2

Molecular functions related to Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:0082339.4ELANE, CTRC, CTSB
2serine-type endopeptidase activityGO:0042529.2CTRC, ELANE, PRSS2, PRSS1, TMPRSS15
3carbohydrate bindingGO:0302469.2REG1A, REG3G, REG3A

Products for genes affiliated with Pancreatitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pancreatitis

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet