MCID: PNC044
MIFTS: 68

Pancreatitis malady

Genetic diseases, Endocrine diseases, Rare diseases, Gastrointestinal diseases, Skin diseases, Bone diseases, Immune diseases categories

Summaries for Pancreatitis

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MedlinePlus:34 The pancreas is a large gland behind the stomach and close to the first part of the small intestine. it secretes digestive juices into the small intestine through a tube called the pancreatic duct. the pancreas also releases the hormones insulin and glucagon into the bloodstream. pancreatitis is inflammation of the pancreas. it happens when digestive enzymes start digesting the pancreas itself. pancreatitis can be acute or chronic. either form is serious and can lead to complications. acute pancreatitis occurs suddenly and usually goes away in a few days with treatment. it is often caused by gallstones. common symptoms are severe pain in the upper abdomen, nausea, and vomiting. treatment is usually a few days in the hospital for intravenous (iv) fluids, antibiotics, and medicines to relieve pain. chronic pancreatitis does not heal or improve. it gets worse over time and leads to permanent damage. the most common cause is heavy alcohol use. other causes include cystic fibrosis and other inherited disorders, high levels of calcium or fats in the blood, some medicines, and autoimmune conditions. symptoms include nausea, vomiting, weight loss, and oily stools. treatment may also be a few days in the hospital for intravenous (iv) fluids, medicines to relieve pain, and nutritional support. after that, you may need to start taking enzymes and eat a special diet. it is also important to not smoke or drink alcohol. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Pancreatitis is related to pancreatic cancer and adenocarcinoma. An important gene associated with Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are ethanol degradation II and Abacavir Pathway, Pharmacokinetics/Pharmacodynamics. The drugs propantheline and propantheline bromide and the compounds epft and h2dids have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, pancreas and liver, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Wikipedia:65 Pancreatitis is inflammation of the pancreas. The pancreas is a large organ behind the stomach which... more...

GeneReviews summary for pancreatitis-ov

Aliases & Classifications for Pancreatitis

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Pancreatitis, Aliases & Descriptions:

Name: Pancreatitis 10 21 12 45 34 62


Classifications:



External Ids:

Disease Ontology10 DOID:4989
NCIt40 C3306
MeSH35 D010195

Related Diseases for Pancreatitis

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Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Acute Pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Spink1-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Cftr-Related Hereditary Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1014)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cancer32.3SCT, SPINK1, CCK
2adenocarcinoma31.8ALDH2, SPINK1, SCT, ADH1C, ADH1B, PRSS1
3acute pancreatitis31.7ADH1C, REG3A, REG1A, LPL, CCK, ALDH2
4exocrine pancreatic insufficiency31.4CFTR, CCK, ELANE, SCT
5alcoholic pancreatitis31.3ADH1C, SPINK1, CFTR, CPB1, SCT, ALDH2
6recurrent acute pancreatitis31.3LPL, SOD1, SPINK1, SCT, CFTR
7cystic fibrosis31.2PRSS1, SPINK1, CFTR, SCT, ELANE, LPL
8hypertriglyceridemia31.0LPL, APOC2
9tropical calcific pancreatitis30.9SPINK1
10steatorrhea30.9CCK, ELANE, TMPRSS15, SCT, CFTR
11adenoma30.9ADH1C, SCT, CTSB, SPINK1, REG1A
12glucagonoma30.8CCK, SCT
13pancreatitis, hereditary30.8PRSS1, CTRC, SPINK1
14hyperinsulinism30.7LPL, CCK, SCT
15cholera30.7CFTR, SCT, CCK
16hyperglycemia30.7LPL, CCK, SCT, SOD1
17duodenal ulcer30.6CCK, SCT
18glucose intolerance30.5APOC2, LPL, ALDH2
19liver cirrhosis30.4ADH1B, ALDH2, ADH1C, SCT
20hepatocellular carcinoma30.4ELANE, REG1A, ALDH2, REG3A, ADH1B, SCT
21gallbladder disease30.3CCK, CFTR
22colorectal cancer30.3PRSS2, SPINK1, CTSB, ALDH2, CCK, LPL
23gastritis30.3SCT, CCK
24alcohol abuse30.2ALDH2, ADH1C
25duodenogastric reflux30.2CCK
26alcoholic liver cirrhosis30.1ALDH2, ADH1B, ADH1C, SOD1
27lung cancer30.1CTSB, ALDH2, CCK, LPL, ADH1C, SPINK1
28diabetes mellitus, insulin-dependent30.1ALDH2, LPL, SOD1, SCT, APOC2, CCK
29aspergillosis30.0ELANE
30morbid obesity30.0LPL, CCK
31rheumatoid arthritis29.9PRSS2, CTSB, LPL, ELANE, CFTR
32pancreas disease29.8CCK, SPINK1, CFTR, SCT, TMPRSS15, ELANE
33atrophic gastritis29.8SOD1, SCT
34coronary artery disease29.8APOC2, LPL, ADH1C
35biliary dyskinesia29.6CCK
36fatty liver disease29.6ALDH2, LPL, SOD1
37vascular disease29.5LPL, ELANE, SOD1, APOC2
38pancreatic ductal adenocarcinoma11.1
39autoimmune pancreatitis11.1
40duodenitis10.9
41neuroendocrine tumor10.8
42hepatitis10.8
43islet cell tumor10.8
44endotheliitis10.8
45cystadenoma10.7
46pancreatic islet cell tumors10.7
47pancreatic ductal carcinoma10.7
48cholangitis10.7
49insulinoma10.7
50hypoxia10.6

Graphical network of the top 20 diseases related to Pancreatitis:



Diseases related to pancreatitis

Symptoms for Pancreatitis

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Drugs & Therapeutics for Pancreatitis

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Drug clinical trials:

Search ClinicalTrials for Pancreatitis

Search NIH Clinical Center for Pancreatitis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Pancreatitis

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Anatomical Context for Pancreatitis

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MalaCards organs/tissues related to Pancreatitis:

33
Pancreatic islet, Pancreas, Liver, Testes, Endothelial, Lung, Kidney, Lymph node, T cells, Breast, Colon, Small intestine, Neutrophil, Bone, Monocytes, B cells, Spleen, Brain, Prostate, Pituitary, Thyroid, Heart, Bone marrow, Ovary, Myeloid, Smooth muscle, Skin, Spinal cord, Adipocyte, Skeletal muscle, Salivary gland, Testis, Cortex, Adrenal cortex, Whole blood, Nk cells, Thymus, Uterus, Cervix, Fetal liver

Animal Models for Pancreatitis or affiliated genes

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MGI Mouse Phenotypes related to Pancreatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.9CFTR, SOD1, REG1A, CCK, CTSB, SPINK1
2MP:00053766.5CTSB, SPINK1, CFTR, SCT, TMPRSS15, SOD1

Publications for Pancreatitis

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Articles related to Pancreatitis:

(show top 50)    (show all 14515)
idTitleAuthorsYear
1
Acute fatty liver of pregnancy with hypoglycaemia, diabetes insipidus and pancreatitis, preceded by intrahepatic cholestasis of pregnancy. (25878236)
2015
2
Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cells. (24297612)
2014
3
Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors. (24025713)
2014
4
Coexisting pancreatic mucinous cyst adenoma and adrenal lymphangioma. (25224209)
2014
5
Perineural mast cells are specifically enriched in pancreatic neuritis and neuropathic pain in pancreatic cancer and chronic pancreatitis. (23555989)
2013
6
Early enteral nutrition is superior to delayed enteral nutrition for the prevention of infected necrosis and mortality in acute pancreatitis. (23508012)
2013
7
Serum immunoglobulin G4 associated with number and distribution of extrapancreatic lesions in type 1 autoimmune pancreatitis patients. (21929654)
2012
8
Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma? (22436573)
2012
9
Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta. (21700708)
2011
10
Transthyretin, identified by proteomics, is overabundant in pancreatic juice from pancreatic carcinoma and originates from pancreatic islets. (20949480)
2011
11
Polyarthritis with chondronecrosis associated with osteonecrosis, panniculitis and pancreatitis. (19575201)
2010
12
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
13
Education and imaging. Hepatobiliary and pancreatic: Epithelioid hemangioendothelioma. (19335787)
2009
14
Panniculitis in a patient presenting with a pancreatic tumour and polyarthritis: a case report. (19830189)
2009
15
Enhanced antitumor effect of combined gemcitabine and proton radiation in the treatment of pancreatic cancer. (19506533)
2009
16
Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth. (19610136)
2009
17
Protective effect of lycopene on oxidative stress-induced cell death of pancreatic acinar cells. (19723106)
2009
18
Obesity alters cytokine gene expression and promotes liver injury in rats with acute pancreatitis. (18223607)
2008
19
Fucosylated haptoglobin is a novel marker for pancreatic cancer: detailed analyses of oligosaccharide structures. (18646007)
2008
20
Pancreatic laceration and portal vein thrombosis in blunt trauma abdomen. (20011472)
2008
21
Evaluation of topoisomerase IIa expression in pancreatic ductal adenocarcinoma: a pilot study using chromogenic in situ hybridization and immunohistochemistry on tissue microarrays. (17449965)
2007
22
Expression of heparanase and nuclear factor kappa B in pancreatic adenocarcinoma]. (17715045)
2007
23
Role of BRCA1 and BRCA2 mutations in pancreatic cancer. (16973716)
2007
24
DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients. (17914106)
2007
25
Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression. (17116388)
2007
26
N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption. (16705170)
2006
27
Recurrent acute pancreatitis in a patient with type IIb hyperlipoproteinemia: a case report and review of the literature in Korea. (16502498)
2006
28
Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer. (16865243)
2006
29
Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. (16568310)
2006
30
Hereditary pancreatitis and secondary screening for early pancreatic cancer. (16358943)
2005
31
Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation. (14565847)
2004
32
Anti-cytokine therapy for severe acute pancreatitis]. (15552897)
2004
33
Gene therapy of pancreatic cancer with green fluorescent protein and tumor necrosis factor-related apoptosis-inducing ligand fusion gene expression driven by a human telomerase reverse transcriptase promoter. (12900367)
2003
34
BRCA2 germline mutations in familial pancreatic carcinoma. (12569143)
2003
35
Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma. (12843152)
2003
36
Laser microdissection of small tissue samples--application to chronic pancreatitis tissues. (12924436)
2003
37
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. (12235117)
2002
38
Detection of choledocholithiasis by EUS in acute pancreatitis: a prospective evaluation in 100 consecutive patients. (11522972)
2001
39
Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells. (10996854)
2000
40
Control of pancreatic bile-salt-dependent-lipase secretion by the glucose-regulated protein of 94 kDa (Grp94). (11104697)
2000
41
Diagnosis of lipid malabsorption in patients with chronic pancreatitis: a new indirect test using postprandial plasma apolipoprotein B-48. (10566720)
1999
42
Imaging of neuroendocrine gastro-entero-pancreatic tumours using radiolabelled somatostatin analogues. (10604128)
1999
43
Intraductal secretin test is as useful as duodenal secretin test in assessing exocrine pancreatic function. (9073129)
1997
44
Enzymatic markers of gallstone-induced pancreatitis identified by ROC curve analysis, discriminant analysis, logistic regression, likelihood ratios, and information theory. (7536644)
1995
45
Pneumocystis carinii pneumonia complicating somatostatin therapy of Cushing's syndrome in a patient with metastatic pancreatic islet cell carcinoma and Zollinger-Ellison syndrome. (1672788)
1991
46
Renal-hepatic-pancreatic dysplasia and its variants. (1741971)
1991
47
Effects of cholecystokinin-receptor blockade on pancreatic and biliary function in healthy volunteers. (2019374)
1991
48
Electron microscopic and immunoelectron microscopic demonstration of pancreatic polypeptide cells in glucagonoma: colocalization of pancreatic peptide and glucagon in single secretory granules. (2537546)
1989
49
Indomethacin-responsive pancreatic cholera. (197410)
1977
50
Meconium ileus; with cystic pancreatic fibrosis and early pulmonary complications. (13422754)
1957

Variations for Pancreatitis

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Expression for genes affiliated with Pancreatitis

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Search GEO for disease gene expression data for Pancreatitis.

Pathways for genes affiliated with Pancreatitis

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Pathways related to Pancreatitis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
acetate conversion to acetyl-CoA38
oxidative ethanol degradation III38
ethanol degradation IV38
10.0ALDH2, ADH1B
29.9ADH1B, ADH1C
3
Show member pathways
9.8ELANE, PRSS2, PRSS1
49.7CPB1, PRSS1, PRSS2
5
Show member pathways
9.6ALDH2, ADH1B, ADH1C
6
Show member pathways
mitochondrial L-carnitine shuttle pathway38
Saturated fatty acid biosynthesis60
9.6ALDH2, ADH1B, ADH1C
7
Show member pathways
9.6ALDH2, ADH1B, ADH1C
8
Show member pathways
glycolysis38
gluconeogenesis38
Glycolysis and Gluconeogenesis38
9.6ALDH2, ADH1B, ADH1C
9
Show member pathways
phenylalanine utilization38
noradrenaline and adrenaline degradation38
phenylalanine degradation IV38
9.6ADH1C, ADH1B, ALDH2
10
Show member pathways
9.6PRSS1, PRSS2, ELANE, CTSB
119.5PRSS2, PRSS1, CPB1, CFTR

Compounds for genes affiliated with Pancreatitis

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Compounds related to Pancreatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1epft4510.4SCT, CCK
2h2dids4510.3SCT, CFTR
3trioleoylglycerol4510.1APOC2, LPL
4taurodeoxycholate4510.1CCK, SCT
5betaine aldehyde45 2611.1ADH1C, ALDH2, ADH1B
6l-bpa4510.1CCK, SCT
7caerulein4510.1CCK, SCT
83a,7a-Dihydroxy-5b-cholestan-26-al2610.0ADH1B, ALDH2, ADH1C
9carbachol45 30 1312.0CFTR, SCT, CCK, CTSB
10biotin45 26 1312.0SCT, LPL, CTSB, CFTR
11cerulein459.9SCT, ELANE, CCK, CTSB
12ibmx45 61 3011.9CCK, LPL, SCT, CFTR
13rsai459.9ALDH2, ADH1C, ADH1B, APOC2
14aprotinin45 1310.9TMPRSS15, PRSS1, ELANE, CTSB
15nitroglycerin45 1310.9ELANE, SOD1, ALDH2
16probucol45 1310.9LPL, REG3A, SOD1
17acetaldehyde30 45 2611.8ALDH2, ADH1C, ADH1B
18caffeine45 30 3 51 26 1314.8CFTR, ELANE, CCK, LPL
19taurocholate459.8CCK, LPL, TMPRSS15, CFTR, SCT
20thyroxine45 2610.8SCT, LPL, CTSB, ELANE
21sodium nitroprusside459.8CCK, ALDH2, SOD1, ELANE
22carbon459.7CTSB, LPL, ELANE, CCK
23valine459.7CTSB, LPL, CFTR, ELANE
24alpha tocopherol459.7ELANE, LPL, ALDH2, SOD1
25isoproterenol45 1310.7SCT, ELANE, LPL, CTSB, CFTR
26indomethacin45 30 61 1312.7CTSB, CFTR, SCT, SOD1, LPL
27norepinephrine45 26 1311.6CCK, CFTR, LPL, SCT, ELANE
28acetylcholine45 51 30 26 1313.6LPL, SCT, CCK, ELANE, CFTR
29glycerol45 26 1311.6ADH1C, ADH1B, LPL, CCK, CFTR
30dopamine45 30 26 1312.6ALDH2, CCK, CFTR, SCT, ADH1B
31ethanol45 51 26 1312.6ADH1C, SCT, ADH1B, ALDH2, CTSB
32creatinine459.5ALDH2, SOD1, APOC2, CTSB, SPINK1
33polyacrylamide459.5ALDH2, APOC2, ADH1B, CTSB
34cyclosporin a45 30 6111.4LPL, CCK, CTSB, ELANE, CFTR, SCT
35pge2459.4CCK, SCT, CTSB, CFTR, ELANE, LPL
36nadph45 2610.4CTSB, ALDH2, ADH1B, ADH1C, SOD1
37lysine459.4APOC2, TMPRSS15, CPB1, ALDH2, SCT
38heparin45 30 26 1312.3TMPRSS15, ELANE, LPL, APOC2, CTSB
39retinoic acid45 2610.3ELANE, ALDH2, CCK, APOC2, SCT, CFTR
40glutamine459.2SCT, CFTR, CTSB, LPL, CCK, ALDH2
41vitamin a45 26 1311.0APOC2, ADH1B, ALDH2, SOD1, ADH1C, ELANE
42zinc45 2610.0SCT, CPB1, SOD1, ADH1C, CTSB, ADH1B
43adenylate459.0CFTR, LPL, CCK, SCT, ELANE
44glutamate458.9CCK, CFTR, SCT, SOD1, ELANE, LPL
45cysteine458.9ELANE, SCT, CTSB, ALDH2, PRSS2, PRSS1
46arginine458.8CTSB, SCT, ALDH2, TMPRSS15, CCK, PRSS1
47calcium45 51 26 1311.6CCK, CTRC, CTSB, PRSS2, REG1A, PRSS1
48glucose458.4SCT, ALDH2, REG1A, CCK, CTSB, LPL
49serine458.3CTSB, CTRC, ELANE, PRSS2, PRSS1, TMPRSS15
50trypsinogen457.8TMPRSS15, SCT, PRSS1, PRSS2, ELANE, REG3A

GO Terms for genes affiliated with Pancreatitis

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Cellular components related to Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:00426279.9LPL, APOC2
2very-low-density lipoprotein particleGO:00343619.7APOC2, LPL
3extracellular matrixGO:00310129.7LPL, PRSS2, SOD1
4extracellular spaceGO:00056158.7APOC2, SOD1, PRSS2, REG3A, LPL, CCK
5extracellular regionGO:00055766.9CTSB, SPINK1, SCT, APOC2, CPB1, SOD1

Biological processes related to Pancreatitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1chylomicron remodelingGO:003437110.3LPL, APOC2
2very-low-density lipoprotein particle remodelingGO:003437210.2LPL, APOC2
3triglyceride homeostasisGO:007032810.0LPL, APOC2
4ethanol oxidationGO:00060699.9ALDH2, ADH1B, ADH1C
5positive regulation of keratinocyte proliferationGO:00108389.9REG3G, REG3A
6collagen catabolic processGO:00305749.9PRSS2, ELANE, CTSB
7negative regulation of keratinocyte differentiationGO:00456179.9REG3G, REG3A
8extracellular matrix disassemblyGO:00226179.8PRSS1, PRSS2, ELANE, CTSB
9proteolysisGO:00065089.8PRSS2, ELANE, CTRC, CTSB
10positive regulation of wound healingGO:00903039.7REG3G, REG3A
11response to drugGO:00424939.6LPL, SOD1, APOC2, CFTR
12extracellular matrix organizationGO:00301989.6PRSS1, PRSS2, ELANE, CTSB
13xenobiotic metabolic processGO:00068059.3ALDH2, ADH1B, ADH1C
14small molecule metabolic processGO:00442818.9APOC2, ADH1C, ADH1B, PRSS1, LPL, ALDH2

Molecular functions related to Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:00082339.4ELANE, CTRC, CTSB
2serine-type endopeptidase activityGO:00042529.2CTRC, ELANE, PRSS2, PRSS1, TMPRSS15
3carbohydrate bindingGO:00302469.2REG1A, REG3G, REG3A

Products for genes affiliated with Pancreatitis

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Sources for Pancreatitis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet