MCID: PNC108
MIFTS: 67

Pancreatitis, Hereditary malady

Categories: Genetic diseases, Rare diseases, Eye diseases, Gastrointestinal diseases, Skin diseases, Metabolic diseases, Endocrine diseases, Blood diseases, Bone diseases, Immune diseases

Aliases & Classifications for Pancreatitis, Hereditary

About this section

Aliases & Descriptions for Pancreatitis, Hereditary:

Name: Pancreatitis, Hereditary 52 70 12
Hermansky-Pudlak Syndrome 11 23 48 24 25 54 50 13
Hereditary Pancreatitis 48 24 25 27 68
Hps 11 48 25 54 2
Hereditary Chronic Pancreatitis 48 25 54
Chronic Pancreatitis 24 70 50
Albinism with Hemorrhagic Diathesis and Pigmented Reticuloendothelial Cells 48 68
Autosomal Dominant Hereditary Pancreatitis 25 68
Pancreatitis, Chronic, Protection Against 52 24
Pancreatitis, Chronic, Susceptibility to 24 27
Hermanski-Pudlak Syndrome 39 68
Hermansky Pudlak Syndrome 48 27
Pancreatitis, Chronic 52 68
 
Pctt 24 70
Hp 25 70
Platelet Storage Pool Deficiency 68
Delta Storage Pool Disease 48
Pancreatitis, Idiopathic 52
Pancreatitis Hereditary 50
Pancreatitis, Calcific 68
Calcific Pancreatitis 24
Familial Pancreatitis 25
Hantavirus Infections 68
Hpc 70
Cp 70

Characteristics:

Orphanet epidemiological data:

54
hereditary chronic pancreatitis:
Inheritance: Autosomal dominant; Prevalence: 1-9/1000000 (France),1-9/1000000 (Denmark),1-9/1000000 (Europe); Age of onset: Adolescent,Childhood; Age of death: elderly
hermansky-pudlak syndrome:
Inheritance: Autosomal recessive; Age of onset: Infancy,Neonatal; Age of death: any age

HPO:

64
pancreatitis, hereditary:
Inheritance: autosomal dominant inheritance

Classifications:



External Ids:

OMIM52 167800
Disease Ontology11 DOID:3753
ICD1030 E70.331
NCIt45 C37261
UMLS via Orphanet69 C0341474
ICD10 via Orphanet31 K86.1, E70.3

Summaries for Pancreatitis, Hereditary

About this section
NIH Rare Diseases:48 Hereditary pancreatitis is a rare genetic condition that causes multiple episodes of pancreatitis. The first episode of pancreatitis usually occurs in late childhood. Signs and symptoms may include stomach pain, fever, nausea, or vomiting. Episodes often lasts from one to three days, but may be longer. Repeat episodes of pancreatitis leads to chronic pancreatitis (a constantly inflamed pancreas), calcium deposits in the pancreas, and over years, pancreas scarring. At this stage signs and symptoms may include fatty stool, weight loss, and protein and vitamin deficiencies. People with hereditary pancreatitis are also at an increased risk for type 1 diabetes and pancreatic cancer, typically in adulthood. In most cases, hereditary pancreatitis is caused by mutations in the PRSS1 gene and passed through families in an autosomal dominant pattern. While there is not a cure for hereditary pancreatitis, treatments are available (visit the Pancreas Foundation to learn more about treatment). With treatment people with hereditary pancreatitis tend to have a normal life expectancy.  Last updated: 1/20/2016

MalaCards based summary: Pancreatitis, Hereditary, also known as hermansky-pudlak syndrome, is related to tropical calcific pancreatitis and chediak-higashi syndrome, and has symptoms including visual impairment, nystagmus and ocular albinism. An important gene associated with Pancreatitis, Hereditary is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways are Cobalamin (Cbl, vitamin B12) transport and metabolism and Protein digestion and absorption. Affiliated tissues include pancreas, skin and testes, and related mouse phenotypes are hearing/vestibular/ear and no phenotypic analysis.

Disease Ontology:11 An autosomal recessive disease characterized by oculocutaneous albinism, bleeding problems due to platelet storage pool defect, visual impairment and lysosomal accumulation of ceroid lipofuscin.

Genetics Home Reference:25 Hereditary pancreatitis is a genetic condition characterized by recurrent episodes of inflammation of the pancreas (pancreatitis). The pancreas produces enzymes that help digest food, and it also produces insulin, a hormone that controls blood sugar levels in the body. Episodes of pancreatitis can lead to permanent tissue damage and loss of pancreatic function.

CDC:2 Infection with hantavirus can progress to Hantavirus Pulmonary Syndrome (HPS), which can be fatal. People become infected through contact with hantavirus-infected rodents or their urine and droppings. The Sin Nombre hantavirus, first recognized in 1993, is one of several New World hantaviruses circulating in the US. Old World hantaviruses, found in Asia, can cause Hemorrhagic Fever with Renal Syndrome (HFRS). Rodent control in and around the home remains the primary strategy for preventing hantavirus infection. All cases of Hantavirus infection are reported to the CDC.

UniProtKB/Swiss-Prot:70 Pancreatitis, hereditary: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.

Wikipedia:71 Hereditary pancreatitis (HP) is an inflammation of the pancreas, attributed to genetic causes. It was... more...

Description from OMIM:52 167800

GeneReviews for NBK1287

Related Diseases for Pancreatitis, Hereditary

About this section

Diseases in the Pancreatitis family:

pancreatitis, hereditary Acute Pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Cftr-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Spink1-Related Hereditary Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Pancreatitis, Hereditary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1tropical calcific pancreatitis31.3CFTR, CPA1, CTRC, ELANE, PRSS1, PRSS2
2chediak-higashi syndrome31.3HPS1, TYR, TYRP1
3hermansky-pudlak syndrome 112.7
4hermansky-pudlak syndrome 512.7
5hermansky-pudlak syndrome 612.7
6hermansky-pudlak syndrome 312.6
7hermansky-pudlak syndrome 212.6
8hermansky-pudlak syndrome 712.6
9hermansky-pudlak syndrome 912.6
10hermansky-pudlak syndrome 812.6
11hermansky-pudlak syndrome 412.5
12hermansky-pudlak syndrome with pulmonary fibrosis12.2
13isolated delta-storage pool disease12.2
14hermansky-pudlak syndrome without pulmonary fibrosis12.1
15prss1-related hereditary pancreatitis11.9
16cftr-related hereditary pancreatitis11.8
17ctrc-related hereditary pancreatitis11.8
18spink1-related hereditary pancreatitis11.8
19hantavirus pulmonary syndrome11.7
20pancreatic cancer11.7
21aceruloplasminemia11.4
22cerebral palsy11.3
23carbamoylphosphate synthetase i deficiency11.1
24cerebral palsy, ataxic, autosomal recessive11.0
25cerebellar ataxia11.0
26wilson disease10.9
27hemochromatosis10.9
28liver disease10.9
29retinal degeneration10.9
30asthma10.9
31menkes disease10.9
32deficiency anemia10.9
33pneumoconiosis10.9
34hemosiderosis10.9
35hemangiopericytoma, malignant10.9
36anemia, hypochromic microcytic10.8
37mastitis10.8
38chronic pyelonephritis10.8
39protein-energy malnutrition10.8
40nutmeg liver10.8
41boutonneuse fever10.8
42iron metabolism disease10.8
43pulmonary tuberculosis10.8
44periapical granuloma10.8
45nutritional deficiency disease10.8
46fascioliasis10.8
47cleft palate, isolated10.8
48negative rheumatoid factor polyarthritis10.8
49van der woude syndrome 210.8
50van der woude syndrome10.8

Comorbidity relations with Pancreatitis, Hereditary via Phenotypic Disease Network (PDN):


Acute PancreatitisAlcohol Abuse
CholangitisCholestasis
Coronary Artery DiseaseDeficiency Anemia
EsophagitisHeart Disease
Hypertension, EssentialIntestinal Obstruction
Ischemic Heart DiseasePancreatic Cancer
Active Peptic Ulcer DiseaseAcute Cystitis
Chronic Kidney FailureParalytic Ileus
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Pancreatitis, Hereditary:



Diseases related to pancreatitis, hereditary

Symptoms & Phenotypes for Pancreatitis, Hereditary

About this section

Symptoms by clinical synopsis from OMIM:

167800

Clinical features from OMIM:

167800

Human phenotypes related to Pancreatitis, Hereditary:

 64 54 (show all 59)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 visual impairment64 54 hallmark (90%) Occasional (29-5%) HP:0000505
2 nystagmus64 54 hallmark (90%) Very frequent (99-80%) HP:0000639
3 ocular albinism64 54 hallmark (90%) Frequent (79-30%) HP:0001107
4 abnormality of coagulation64 hallmark (90%) HP:0001928
5 generalized hypopigmentation64 hallmark (90%) HP:0007513
6 renal insufficiency64 54 typical (50%) Frequent (79-30%) HP:0000083
7 abnormality of the menstrual cycle64 typical (50%) HP:0000140
8 epistaxis64 54 typical (50%) Frequent (79-30%) HP:0000421
9 astigmatism64 54 typical (50%) Frequent (79-30%) HP:0000483
10 strabismus64 54 typical (50%) Frequent (79-30%) HP:0000486
11 cataract64 54 typical (50%) Frequent (79-30%) HP:0000518
12 myopia64 54 typical (50%) Frequent (79-30%) HP:0000545
13 photophobia64 54 typical (50%) Frequent (79-30%) HP:0000613
14 optic atrophy64 typical (50%) HP:0000648
15 abnormality of visual evoked potentials64 54 typical (50%) Frequent (79-30%) HP:0000649
16 bruising susceptibility64 54 typical (50%) Frequent (79-30%) HP:0000978
17 abnormality of the macula64 typical (50%) HP:0001103
18 pulmonary fibrosis64 54 typical (50%) Frequent (79-30%) HP:0002206
19 hypopigmentation of hair64 54 typical (50%) Frequent (79-30%) HP:0005599
20 abnormality of the eyelashes64 occasional (7.5%) HP:0000499
21 abnormality of dental enamel64 54 occasional (7.5%) Occasional (29-5%) HP:0000682
22 hyperkeratosis64 54 occasional (7.5%) Occasional (29-5%) HP:0000962
23 melanocytic nevus64 54 occasional (7.5%) Occasional (29-5%) HP:0000995
24 hypertrophic cardiomyopathy64 occasional (7.5%) HP:0001639
25 weight loss64 54 occasional (7.5%) Occasional (29-5%) HP:0001824
26 abnormality of thrombocytes64 54 occasional (7.5%) Occasional (29-5%) HP:0001872
27 abnormality of neutrophils64 occasional (7.5%) HP:0001874
28 malabsorption64 54 occasional (7.5%) Occasional (29-5%) HP:0002024
29 abdominal pain64 54 occasional (7.5%) Occasional (29-5%) HP:0002027
30 inflammation of the large intestine64 occasional (7.5%) HP:0002037
31 respiratory insufficiency64 occasional (7.5%) HP:0002093
32 gastrointestinal hemorrhage64 54 occasional (7.5%) Occasional (29-5%) HP:0002239
33 neoplasm of the skin64 occasional (7.5%) HP:0008069
34 diabetes mellitus64 HP:0000819
35 pancreatitis64 HP:0001733
36 exocrine pancreatic insufficiency64 HP:0001738
37 fever64 HP:0001945
38 abnormal thrombosis64 HP:0001977
39 pleural effusion64 HP:0002202
40 steatorrhea64 HP:0002570
41 pancreatic pseudocyst64 HP:0005206
42 pancreatic calcification64 HP:0005213
43 long eyelashes54 Occasional (29-5%)
44 abnormality of the optic nerve54 Frequent (79-30%)
45 hypopigmentation of the skin54 Very frequent (99-80%)
46 thickened skin54 Occasional (29-5%)
47 cardiomyopathy54 Occasional (29-5%)
48 neutropenia54 Very frequent (99-80%)
49 abnormal bleeding54 Very frequent (99-80%)
50 anorexia54 Occasional (29-5%)
51 dyspnea54 Occasional (29-5%)
52 basal cell carcinoma54 Occasional (29-5%)
53 immunodeficiency54 Very frequent (99-80%)
54 squamous cell carcinoma of the skin54 Occasional (29-5%)
55 partial albinism54 Very frequent (99-80%)
56 iris hypopigmentation54 Very frequent (99-80%)
57 fatigue54 Occasional (29-5%)
58 crohn's disease54 Occasional (29-5%)
59 menometrorrhagia54 Frequent (79-30%)

UMLS symptoms related to Pancreatitis, Hereditary:


achromia of skin, pruritus, abdominal pain

MGI Mouse Phenotypes related to Pancreatitis, Hereditary according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537710.6AP3B1, HPS1, HPS4, HPS5, HPS6, TYRP1
2MP:000301210.4AP3B1, CFTR, HPS1, HPS3, HPS5, SPINK1
3MP:000538210.3AP3B1, CFTR, HPS1, HPS4, HPS5, HPS6
4MP:000536710.2AP3B1, CD63, DTNBP1, HPS1, HPS4, HPS5
5MP:000118610.1AP3B1, DTNBP1, HPS1, HPS3, HPS4, HPS5
6MP:00053979.9AP3B1, CFTR, DTNBP1, ELANE, HPS1, HPS3
7MP:00107719.8AP3B1, DTNBP1, HPS1, HPS3, HPS4, HPS5
8MP:00053879.8AP3B1, CFTR, DTNBP1, ELANE, HPS1, HPS3
9MP:00053769.3AP3B1, CD63, CFTR, DTNBP1, ELANE, HPS1
10MP:00053919.2AP3B1, CFTR, DTNBP1, HPS1, HPS3, HPS4

Drugs & Therapeutics for Pancreatitis, Hereditary

About this section

Drugs for Pancreatitis, Hereditary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 210)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PancrelipaseapprovedPhase 4, Phase 3, Phase 2, Phase 1, Early Phase 193553608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
PA
 
Pancreatic alpha-amylase precursor
Pancrelipase (amylase
lipase
protease)
2
Dexmedetomidineapproved, vet_approvedPhase 454076631-46-4, 113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
 
Dexdor (T)
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex (TN)
Tocris-2023
ZINC04632106
3
SomatostatinapprovedPhase 422938916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
4
Propofolapproved, investigational, vet_approvedPhase 410282078-54-84943
Synonyms:
2, 6-Diisopropylphenol
2,6 Diisopropylphenol
2,6-Bis(1-methylethyl)phenol
2,6-Bis(Isopropyl)-phenol
2,6-DIISOPROPYLPHENOL
2,6-Diisopropyl phenol
2,6-Diisopropylphenol
2,6-bis(1-methylethyl)-phenol
2,6-di(propan-2-yl)phenol
2078-54-8
28449-97-0
4-06-00-03435 (Beilstein Handbook Reference)
50356-15-5
AB00513968
AC-2038
AC1L1J9Y
AC1Q1OUI
AI3-26295
AM-149
Abbott Brand of Propofol
Alpha Brand of Propofol
Ampofol
Aquafol
Astra Brand of Propofol
AstraZeneca Brand of Propofol
BIDD:GT0436
BPBio1_000950
BPBio1_000969
BRD-K82255054-001-03-5
BRN 1866484
BSPBio_000862
Biomol-NT_000248
Braun Brand of Propofol
C07523
C12H18O
CAS-2078-54-8
CCRIS 9000
CHEBI:44915
CHEMBL526
CID4943
CPD-11437
CPD000059151
Curamed Brand of Propofol
D00549
D015742
D0617
D126608
D126608_ALDRICH
DB00818
DDS-04F
Diisopropylphenol
Dipravan
Diprivan
Diprivan (TN)
Diprivan Injectable emulsion
Disoprivan
Disoprofol
EINECS 218-206-6
EU-0100437
Fresenius Brand of Propofol
Fresenius Kabi Brand of Propofol
Fresofol
HMS1570L04
HMS2089O21
HMS2094E17
 
HSDB 7123
ICI 35,868
ICI 35868
ICI-35,868
ICI-35868
ICI35,868
ICI35868
InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H
Ivofol
Jsp004266
Juste Brand of Propofol
LS-996
Lopac-D126608
Lopac0_000437
MLS001066348
MLS001335999
MLS002454360
MolPort-001-794-517
NCGC00015389-01
NCGC00015389-02
NCGC00015389-04
NCGC00015389-09
NCGC00091538-01
NCGC00091538-02
NCGC00091538-03
NCGC00091538-04
NCGC00091538-05
NCGC00091538-06
NSC 5105
NSC5105
PFL
Parnell Brand of Propofol
Pisa Brand of Propofol
Prestwick0_000931
Prestwick1_000931
Prestwick2_000931
Prestwick3_000931
Propofol
Propofol (JAN/USAN/INN)
Propofol Abbott
Propofol Fresenius
Propofol IDD-D
Propofol MCT
Propofol Rovi
Propofol [USAN:INN:BAN]
Propofol(2,6-Diisopropylphenol)
Propofol-Lipuro
Propofolum
Propofolum [Latin]
Rapinovet
Recofol
Rovi Brand of Propofol
S01-0189
SAM002264610
SMR000059151
SPBio_003031
SPECTRUM1505022
ST50405911
Schering Brand of Propofol
UNII-YI7VU623SF
W505102_ALDRICH
ZD-0859
ZINC00968303
Zeneca Brand of Propofol
ghl.PD_Mitscher_leg0.558
nchembio.552-comp7
propofol
5
Octreotideapproved, investigationalPhase 421383150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
 
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
6
Indomethacinapproved, investigationalPhase 411453-86-13715
Synonyms:
1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
1z9h
37242-43-6
503560-73-4
53-86-1
74252-25-8 (hydrochloride salt, tri-hydrate)
7681-54-1 (hydrochloride salt)
91853-74-6
AB00052022
AC-532
AC1L1GJQ
AKOS000592893
Aconip
Aconip (TN)
Amuno
Apo-Indomethacin
Arthrexin
Artracin
Artrinovo
Artrivia
BIDD:GT0132
BIM-0050670.0001
BPBio1_000160
BRD-K57222227-001-06-1
BRN 0497341
BSPBio_000144
BSPBio_001149
BSPBio_002176
Bio-0704
Bio2_000405
Bio2_000885
Bonidin
Bonidon
Bonidon Gel
C01926
CAS-53-86-1
CCRIS 3502
CHEBI:49662
CHEMBL6
CID3715
CPD-10545
Catlep
Chibro-amuno
Chrono-indicid
Chrono-indocid
Confortid
D00141
DB00328
DESMETHYL INDOMETHACIN
DivK1c_000271
Dolcidium
Dolcidium PL
Dolovin
Durametacin
EINECS 200-186-5
EU-0100692
Elmetacin
Flexin continus
HMS1362I11
HMS1568H06
HMS1792I11
HMS1920F21
HMS1990I11
HMS2089N19
HMS2091N09
HMS500N13
HSDB 3101
Hicin
I 7378
I0655
I7378_SIGMA
I8280_SIGMA
IDI1_000271
IDI1_002160
IMN
IN1454
Idomethine
Imbrilon
Inacid
Indacin
Indameth
Indmethacine
Indo-Lemmon
Indo-Spray
Indo-phlogont
Indo-rectolmin
Indo-tablinen
Indocid
Indocid (pharmaceutical)
Indocid Pda
Indocid Sr
Indocin
Indocin (TN)
Indocin I.V
Indocin I.V.
Indocin Sr
Indolar SR
Indomecol
Indomed
Indomee
Indomet 140
Indometacin
Indometacin (JP15/INN)
Indometacina
Indometacina [INN-Spanish]
Indometacine
Indometacine [INN-French]
Indometacinum
 
Indometacinum [INN-Latin]
Indometacyna
Indometacyna [Polish]
Indomethacin
Indomethacin & MAP-30
Indomethacin (USP)
Indomethacin [USAN:BAN]
Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin
Indomethacine
Indomethacinum
Indomethancin
Indomethazine
Indomethegan
Indomethine
Indometicina
Indometicina [Spanish]
Indomo
Indomod
Indoptic
Indoptol
Indorektal
Indoxen
Inflazon
Infrocin
Inteban sp
KBio1_000271
KBio2_000489
KBio2_001399
KBio2_003057
KBio2_003967
KBio2_005625
KBio2_006535
KBio3_000897
KBio3_000898
KBio3_001396
KBioGR_000395
KBioGR_000489
KBioSS_000489
KBioSS_001399
L000959
LS-187
LS-82147
Lausit
Liometacen
Lopac-I-7378
Lopac0_000692
MLS000069402
MLS000758212
MLS001074194
Metacen
Metartril
Methazine
Metindol
Mezolin
Miametan
Mikametan
Mobilan
MolMap_000032
MolPort-000-917-894
NCGC00015562-01
NCGC00015562-02
NCGC00015562-03
NCGC00015562-08
NCGC00015562-19
NCGC00024135-02
NCGC00024135-04
NCGC00024135-05
NCGC00024135-06
NCGC00024135-07
NCGC00024135-08
NCGC00024135-09
NCGC00024135-11
NCI-C56144
NCI60_041708
NINDS_000271
Novo-Methacin
Novomethacin
Oprea1_686105
Prestwick0_000272
Prestwick1_000272
Prestwick2_000272
Prestwick3_000272
Prestwick_597
Reumacide
Rhemacin LA
Rheumacin LA
S00108
S1723_Selleck
SMR000058195
SMR000449290
SPBio_000979
SPBio_002363
SPECTRUM1500350
Sadoreum
Spectrum2_000970
Spectrum3_000468
Spectrum4_000018
Spectrum5_000868
Spectrum_000919
Tannex
Tocris-1708
UNII-XXE1CET956
UPCMLD-DP023
UPCMLD-DP023:001
USAN
Vonum
indometacin
indomethacin
nchembio.147-comp11
{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid
7
Glycerolexperimental, approvedPhase 422356-81-5753
Synonyms:
1,2,3-Trihydroxypropane
1,2,3-propanetriol
1,2,3-trihydroxypropane
Bulbold
Cristal
E 422
Emery 916
Glyceol Opthalgan
Glycerin
Glycerin, anhydrous
Glycerin,anhydrous
Glycerine
Glycerinum
 
Glyceritol
Glycerol
Glycyl alcohol
Glyrol
Glysanin
IFP
Incorporation factor
Mackstat H 66
Monoctanoin component D
Osmoglyn
Pricerine 9091
Propanetriol
RG-S
Trihydroxypropane
Tryhydroxypropane
8
Etanerceptapproved, investigationalPhase 4397185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
9
Cholecalciferolapproved, nutraceuticalPhase 485167-97-06221, 10883523, 5280795
Synonyms:
()-Vitamin D3
(+)-Vitamin D3
(+)-vitamin D3
(1S,3Z)-3-[(2e)-2-[(1R,3AR,7as)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(3beta,5Z,7e)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
(3beta,Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
(5E,7E)-9,10-Secocholesta-5,7,10-trien-3-ol
(5Z,7E)-(3S)-9,10-seco-5,7,10(19)-cholestatrien-3-ol
(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(5Z,7e)-(3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
1406-16-2
25(OH)D
3-beta,Z,7E-9,10-Secocholestr-5,7,10(19)-trien-3-ol
47763_SUPELCO
57651-82-8
67-97-0
7-Dehydrocholesterol activated
7-Dehydrocholesterol, Activated
7-Dehydrocholesterol, irradiated
7-Dehydrocholestrol, activated
8024-19-9
8050-67-7
89193_FLUKA
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3-ol
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3beta-ol
9,10-Secocholesta-5(Z),7(E),10(19)-trien-3(.beta.)-ol
9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol
9,10-Secocholesta-5,7,10(19)-trien-3-ol
9,10-Secocholesta-5,7,10-trien-3-ol
AB1002422
AC-11697
AC1L1ECK
AC1L1M23
AC1LU7IZ
AC1NQXLN
AC1NR2UO
AC1NR2UR
AC1NR2UU
AC1NS4AJ
AC1NSHJX
AC1O5EOF
AC1O7GAV
AC1O7GQ3
AC1O8FEU
AC1O8PWJ
AC1OF2GI
AC1OF2GL
AC1OIEW5
AC1OIEWB
ACon1_001997
Activated 7-dehydrocholesterol
Arachitol
BPBio1_000460
BSPBio_000418
BSPBio_002408
Bio-0845
C05443
C1357_SIAL
C27H44O
C9756_SIGMA
C9774_SIAL
CAS-67-97-0
CC
CCRIS 5813
CCRIS 6286
CHEBI:283119
CHEBI:28940
CHEMBL1042
CHEMBL432780
CID10000117
CID10045875
CID10340013
CID10883523
CID10894379
CID11014566
CID11025493
CID11058152
CID11463269
CID1548921
CID2735
CID5280795
CID5283710
CID5283711
CID5283712
CID5353527
CID5363362
CID6221
CID6432644
CID6604201
CID6604662
CID6708595
CID6713938
CID6992015
CID6992016
CID7067439
CID7067440
CID7251172
CID7251174
CID9821465
Calciol
Cholecalciferol
Cholecalciferol (D3)
Cholecalciferol (JP15/USP)
Cholecalciferol D3
Cholecalciferol [USAN:BAN:JAN]
Cholecalciferol, D3
Cholecalciferolum
 
Colecalciferol
Colecalciferol (INN)
Colecalciferolo
Colecalciferolo [DCIT]
Colecalciferolum
Colecalciferolum [INN-Latin]
Colecalcipherol
D00188
D3-Vicotrat
D3-Vigantol
DB00169
Delsterol
Delta-D
Delta-D (TN)
Deparal
Devaron
DivK1c_006276
Duphafral D3 1000
EINECS 200-673-2
EINECS 215-797-2
EPA Pesticide Chemical Code 202901
Ebivit
FeraCol
Granuvit D3
HMS1569E20
HMS2092M12
HSDB 820
I05-0041
Irradiated 7-dehydrocholesterol
KBio1_001220
KBio2_001643
KBio2_004211
KBio2_006779
KBio3_001628
KBioGR_001602
KBioSS_001643
LMST03020001
LMST03020219
LMST03020220
LMST03020221
LS-1570
LS-825
LT00244775
MEGxm0_000458
Micro-dee
MolPort-001-740-051
MolPort-001-785-972
MolPort-003-666-021
MolPort-004-946-964
NCGC00016301-01
NCGC00017328-01
NCGC00091072-01
NCGC00142511-01
NCGC00159331-02
NCGC00159331-04
NCGC00178668-01
NCGC00179565-01
NCGC00179565-02
NEO Dohyfral D3
NSC 375571
NSC-375571
NSC375571
Oleovitamin D3
Prestwick0_000429
Prestwick1_000429
Prestwick2_000429
Prestwick3_000429
Prestwick_63
Provitamine
Provitina
Quintox
Rampage
Ricketon
SMP1_000068
SPBio_001298
SPBio_002357
SR-05000001559
SR-05000001559-3
ST057172
SpecPlus_000180
Spectrum2_001369
Spectrum3_000764
Spectrum4_001201
Spectrum_001163
TNP00266
Trivitan
UNII-1C6V77QF41
UPCMLD-DP152
UPCMLD-DP152:001
VITAMIN D
VITAMIN D3 POWDER
VITAMIN_D3
Vi-De3
Vi-de-3-hydrosol
VidDe-3-hydrosol
Videkhol
Vigantol
Vigorsan
Vitamin D3
Vitamin D3 emulsifiable
Vitinc Dan-Dee-3
ZINC04474460
ZINC04492874
ZINC04492875
ZINC04492876
ZINC04492878
bmse000507
calciol
cholecalciferol
delta-D
vitamin d-3
10
Ergocalciferolapproved, nutraceuticalPhase 4123250-14-65280793
Synonyms:
'Ergosterol irradiated'
(+)-Vitamin D2
(3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol
(3S,5Z,7E,14xi,17alpha,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3beta,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3beta,5Z,7e,22e)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
(5E,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
22-Tetraen 3beta 9,10,Secoergosta-5,7,10(19)-ol
31316-19-5
4-Methylene-3-[2-[tetrahydro-7a-methyl-1-(1,4,5-trimethyl-2-hexenyl)-4(3aH)-indanylidene]ethylidene]-Cyclohexanol
47768_SUPELCO
50-14-6
7489-18-1
7E677DC1-E1C4-4FC5-8F4A-BCE1857F7E87
8017-28-5
9,10,Secoergosta-5,7,10(19),22-tetraen 3.beta.-ol
9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3b-ol
95220_FLUKA
95220_SIGMA
AC-1355
AC1L1FIE
AC1NQXLH
AC1NS4DE
AC1NS9GI
AC1NSSVD
AC1NWAM3
AC1O5EDK
AC1O6WAM
ACon1_002187
Activated ergosterol
BPBio1_000418
BSPBio_000380
BSPBio_001974
Buco-D
C05441
C28H44O
CALCIFEROL IN A GELATIN MATRIX
CALCIFEROL, U.S.P.
CHEBI:28934
CHEMBL1536
CID11003810
CID3249
CID5280793
CID5315257
CID5353610
CID5356615
CID5702050
CID6432478
CID6536972
Calciferol
Calciferol (TN)
Calciferol (vitamin D2)
Calciferolum
Calciferon 2
Condacaps
Condocaps
Condol
Crtron
Crystallina
D-Arthin
D-Tracetten
D00187
DB00153
Daral
Davitamon D
Davitin
De-rat concentrate
Decaps
Dee-Osterol
Dee-Ron
Dee-Ronal
Dee-Roual
Deltalin
Deratol
Detalup
Diactol
Divit urto
Doral
Drisdol
Drisdol (TN)
E5750_SIGMA
EINECS 200-014-9
Ercalciol
Ergocalciferol
Ergocalciferol (D2)
Ergocalciferol (JP15/USP)
Ergocalciferol [INN:BAN:JAN]
Ergocalciferol oil
Ergocalciferol: Vitamin D
 
Ergocalciferolo
Ergocalciferolo [DCIT]
Ergocalciferols
Ergocalciferolum
Ergocalciferolum [INN-Latin]
Ergorone
Ergosterol activated
Ergosterol irradiated
Ergosterol, irradiated
Ertron
Fortodyl
Geltabs
Geltabs Vitamin D
HMS1920K20
HMS2091B19
HMS502I07
HSDB 819
Haliver
Hi-Deratol
Hyperkil
I05-0022
IDI1_000805
Infron
Irradiated ergosta-5,7,22-trien-3-beta-ol
Irradiated ergosta-5,7,22-trien-3.beta.-ol
Irradiated ergosta-5,7,22-trien-3beta-ol
Irradiated ergosterol
LMST03010001
LMST03010014
LS-3228
MEGxm0_000466
MLS001332467
MLS001332468
Metadee
Mina D2
MolPort-001-740-057
MolPort-001-793-930
MolPort-002-526-645
MolPort-003-666-178
MolPort-006-822-629
Mulsiferol
Mykostin
NCGC00142497-01
NCGC00179579-01
NCGC00179579-02
NSC 62792
NSC62792
Novovitamin-D
Oleovitamin D
Oleovitamin D, Synthetic
Oleovitamin D2
Osteil
Ostelin
Prestwick3_000420
Prestwick_554
Radiostol
Radstein
Radsterin
Rodine C
Rodinec
SMR000857106
SPECTRUM1500276
ST057150
STOCK1N-53397
Shock-ferol
Shock-ferol sterogyl
Sorex C.R
Sorex C.R.
Spectrum5_000666
Sterogyl
Synthetic Vitamin D
UNII-VS041H42XC
Uvesterol D
Uvesterol-D
VITAMIN D2
VITAMIN D2 WATER DISPERSABLE U.S.P.
VITAMIN_D2
Vigantol
Vio D
Vio-D
Viostdrol
Viosterol
Viosterol in Oil
Vitamin D2
Vitamin- D2
Vitamin-?D2
Vitamina D2
Vitavel-D
WLN: L56 FYTJ A1 BY1&1U1Y1&Y1&1 FU2U- BL6YYTJ AU1 DQ
ZINC04474571
ZINC04629876
beta-Ol
bmse000510
component of Geltabs Vitamin D
delta-Arthin
delta-Tracetten
ergocalciferol
vitamin d-2
11Hormone AntagonistsPhase 4, Phase 3, Phase 2, Phase 1, Early Phase 112778
12pancreatinPhase 4, Phase 3, Phase 2, Phase 1, Early Phase 1935
13HormonesPhase 4, Phase 3, Phase 2, Phase 1, Early Phase 113979
14Insulin, Globin ZincPhase 4, Phase 24523
15Protective AgentsPhase 4, Phase 2, Phase 3, Phase 17190
16Hypoglycemic AgentsPhase 4, Phase 25733
17Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 3, Phase 2, Phase 1, Early Phase 112767
18insulinPhase 4, Phase 24524
19VitaminsPhase 4, Phase 2, Phase 3, Phase 1, Early Phase 15095
20Trace ElementsPhase 4, Phase 2, Phase 3, Phase 1, Early Phase 15802
21Gastrointestinal AgentsPhase 4, Phase 3, Phase 2, Phase 1, Early Phase 18109
22MicronutrientsPhase 4, Phase 2, Phase 3, Phase 1, Early Phase 15802
23Antineoplastic Agents, HormonalPhase 45407
24Sitagliptin PhosphatePhase 4416
25
protease inhibitorsPhase 4, Phase 1, Phase 25320
Synonyms:
 
protease inhibitors
26vitamin dPhase 41653
27Analgesics, Non-NarcoticPhase 4, Phase 2, Phase 16260
28Bone Density Conservation AgentsPhase 43266
29Immunosuppressive AgentsPhase 4, Phase 3, Phase 212770
30ErgocalciferolsPhase 41232
31Anti-Inflammatory AgentsPhase 4, Phase 3, Phase 2, Phase 110355
32Antirheumatic AgentsPhase 4, Phase 1, Phase 210627
33Peripheral Nervous System AgentsPhase 4, Phase 2, Phase 3, Phase 122776
34Dipeptidyl-Peptidase IV InhibitorsPhase 4846
35Neurotransmitter AgentsPhase 4, Phase 2, Phase 117734
36Hypnotics and SedativesPhase 4, Phase 22485
37AnalgesicsPhase 4, Phase 2, Phase 3, Phase 111287
38HIV Protease InhibitorsPhase 4, Phase 1, Phase 25319
39Adrenergic alpha-AgonistsPhase 41625
40Adrenergic AgonistsPhase 42877
41Central Nervous System DepressantsPhase 4, Phase 2, Phase 312806
42IncretinsPhase 4, Phase 21537
43Adrenergic alpha-2 Receptor AgonistsPhase 4911
44Adrenergic AgentsPhase 45140
45Anti-Inflammatory Agents, Non-SteroidalPhase 4, Phase 2, Phase 14295
46Protein CPhase 4, Phase 1, Phase 2115
47Protein C InhibitorPhase 4, Phase 1, Phase 297
48Trypsin InhibitorsPhase 4, Phase 1, Phase 2122
49Alpha 1-AntitrypsinPhase 4, Phase 1, Phase 299
50Serine Proteinase InhibitorsPhase 4, Phase 1, Phase 2850

Interventional clinical trials:

(show top 50)    (show all 168)
idNameStatusNCT IDPhase
1Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic PancreatitisCompletedNCT00957151Phase 4
2Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific PancreatitisCompletedNCT00956839Phase 4
3Enzyme Suppletion in Exocrine Pancreatic DysfunctionCompletedNCT01430234Phase 4
4Prospective Study of Celiac Block Injection: 1 vs. 2CompletedNCT00583479Phase 4
5Dexmedetomidine Versus Placebo in Endoscopic Retrograde Cholangiopancreatography (ERCP) SedationCompletedNCT01070680Phase 4
6Sitagliptin Therapy to Improve Outcomes After Islet AutotransplantCompletedNCT01186562Phase 4
7Somatostatin, Octreotide, Pentoxyfilline in the Prevention of Post-ERCP Pancreatitis and Molecular MarkersCompletedNCT00222092Phase 4
8WallFlex Biliary Fully Covered (FC) Chronic Pancreatitis StudyRecruitingNCT01543256Phase 4
9Early Oral Versus Enteral Nutrition After PancreatoduodenectomyRecruitingNCT01642875Phase 4
10Lipidomics, Proteomics, Micro RNAs and Volatile Organic CompoundsRecruitingNCT02531607Phase 4
11Rectal Indomethacin to Prevent Post ESWL-pancreatitisRecruitingNCT02797067Phase 4
12Anti-inflammatory Therapy to Improve Outcomes After TPIATNot yet recruitingNCT02713997Phase 4
13Intraduodenal Aspiration Study to Assess the Bioavailability of Oral Pancrecarb® Compared to Placebo ControlTerminatedNCT00744250Phase 4
14EUROPAC-2 - Pain Treatment of Hereditary and Idiopathic PancreatitisUnknown statusNCT00142233Phase 2, Phase 3
15Role of Antioxidants Supplementation in Chronic PancreatitisCompletedNCT00319358Phase 3
16Pain and Chronic Pancreatitis - Clinical End Experimental StudiesCompletedNCT00755573Phase 2, Phase 3
17Efficacy of EUS-guided Celiac Plexus Blockade in Chronic PancreatitisCompletedNCT00658736Phase 3
18A Study to Investigate the Effect of Delayed Release Pancrelipase on Maldigestion in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis and PancreatectomyCompletedNCT00414908Phase 3
19A Randomized, Double-Blind, Dose Response-Control, Crossover Study to Evaluate the Safety and Efficacy of Two Doses of EUR-1008 (APT-1008) in Chronic Pancreatitis (CP) Participants With Exocrine Pancreatic Insufficiency (EPI)CompletedNCT00788593Phase 3
20A Open-label Study to Assess the Safety of Oral Long-term Use of SA-001 in Pancreatic Exocrine InsufficiencyCompletedNCT00401076Phase 3
21Creon 40,000 for Treatment of PEI (Pancreatic Exocrine Insufficiency) Due to Chronic PancreatitisCompletedNCT00705978Phase 3
22A Study of SA-001 to Treat Pancreatic Exocrine InsufficiencyCompletedNCT00400842Phase 3
23Safety and Efficacy Study of Viokase® 16 for the Correction of SteatorrheaCompletedNCT00559364Phase 3
24Safety and Efficacy of Synthetic Human Secretin-Enhanced MRCP in Subjects With Abnormalities of the PancreasCompletedNCT00660335Phase 3
25Nonstented Stump-closed vs Duct-to-Mucosa Pancreaticojejunostomy After PancreaticoduodenectomyCompletedNCT01731821Phase 3
26Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic PainCompletedNCT00343733Phase 3
27Prospective Study on Endoscopic Ultrasound (EUS) Celiac Bloc Efficacy in Chronic PancreatitisRecruitingNCT01318590Phase 3
28EUS-guided CGN for Inoperable CancerRecruitingNCT02356640Phase 2, Phase 3
29Efficacy and Safety of Reparixin in Pancreatic Islet Auto-transplantationActive, not recruitingNCT01967888Phase 2, Phase 3
30WallFlex Biliary Fully Covered (FC) Benign Stricture StudyActive, not recruitingNCT01014390Phase 3
31Pentoxifylline Treatment in Acute Pancreatitis (AP)Enrolling by invitationNCT02487225Phase 3
32Phase III ALTU-135 CP Safety TrialTerminatedNCT00500084Phase 3
33TMS for the Treatment of Pancreatic Cancer PainUnknown statusNCT00324428Phase 2
34The Effect of Pancreatic Polypeptide on Insulin Requirements for Type 1 & Post-pancreatectomy Diabetic PatientsUnknown statusNCT00791076Phase 2
35A Pilot Study of Use of Calcium Channel Blocker to Decrease Inflammation and Pain in Hereditary PancreatitisCompletedNCT00156403Phase 1, Phase 2
36Secretin Infusion for Pain Due to Chronic PancreatitisCompletedNCT01265875Phase 1, Phase 2
37Chronic Pancreatitis. Effect of Pioglitazone on Endocrine Function, Exocrine Function & Structure, Pain & Life QualityCompletedNCT00782795Phase 2
38Δ9-THC (Namisol®) in Chronic Pancreatitis Patients Suffering From Persistent Abdominal PainCompletedNCT01551511Phase 2
39TMS Treatment for Pain in Chronic PancreatitisCompletedNCT00250484Phase 2
40BreathID® Test: A Non-invasive Modality to Detect Pancreatic Exocrine InsufficiencyCompletedNCT01259544Phase 2
41Comparison of Extracorporeal Shock Wave Lithotripsy (ESWL) Alone and ESWL Plus Endoscopy for Painful Chronic PancreatitisCompletedNCT00133835Phase 1, Phase 2
42Efficacy Study of Δ9-THC to Treat Chronic Abdominal PainCompletedNCT01318369Phase 2
43An Open-Label Study to Evaluate the Intraduodenal Delivery of Enzymes From Administration of VIOKASE16 in Exocrine Pancreatic Insufficiency (EPI)CompletedNCT00559052Phase 2
44Rituximab in IgG4-related Disease: A Phase 1-2 TrialCompletedNCT01584388Phase 1, Phase 2
45Liraglutide to Improve corONary Haemodynamics During Exercise streSSCompletedNCT02315001Phase 2
46Fat Malabsorption in Chronic PancreatitisRecruitingNCT02849704Phase 2
47Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic PancreatitisRecruitingNCT02947087Phase 1, Phase 2
48Pancreatic Perfusion Using Secretin and MRIRecruitingNCT02458118Phase 1, Phase 2
49Simvastatin in Reducing Pancreatitis in Patients With Recurrent, Acute or Chronic PancreatitisRecruitingNCT02743364Phase 2
50WallFlex Pancreatic Metal Stent for Pancreatic Duct StricturesRecruitingNCT02802020Phase 1, Phase 2

Search NIH Clinical Center for Pancreatitis, Hereditary


Cochrane evidence based reviews: hermanski-pudlak syndrome

Genetic Tests for Pancreatitis, Hereditary

About this section

Genetic tests related to Pancreatitis, Hereditary:

id Genetic test Affiliating Genes
1 Hereditary Pancreatitis27 24 SPINK1
2 Hermansky-Pudlak Syndrome27 24 HPS6
3 Pancreatitis, Chronic, Susceptibility to27
4 Chronic Pancreatitis27
5 Pancreatitis, Chronic, Protection Against24 PRSS2

Anatomical Context for Pancreatitis, Hereditary

About this section

MalaCards organs/tissues related to Pancreatitis, Hereditary:

36
Pancreas, Skin, Testes, Bone, Pancreatic islet, Neutrophil, Myeloid

Publications for Pancreatitis, Hereditary

About this section

Articles related to Pancreatitis, Hereditary:

idTitleAuthorsYear
1
An uncommon cause of acute pancreatitis. Hereditary angioedema-induced acute pancreatitis. (21110969)
2011
2
Gene symbol: PRSS1. Disease: Pancreatitis, hereditary. Accession #Hm0542. (17297697)
2006

Variations for Pancreatitis, Hereditary

About this section

UniProtKB/Swiss-Prot genetic disease variations for Pancreatitis, Hereditary:

70 (show all 25)
id Symbol AA change Variation ID SNP ID
1CTRCp.Ala73ThrVAR_043520rs515726209
2CTRCp.Gly217ArgVAR_043522
3CTRCp.Gly217SerVAR_043523rs202058123
4CTRCp.Val235IleVAR_043527rs140993290
5CTRCp.Pro249LeuVAR_043528rs142560329
6CTRCp.Arg254TrpVAR_043529rs121909293
7CTRCp.Gly32ValVAR_070522
8CTRCp.Cys155TyrVAR_070526
9CTRCp.Gln178ArgVAR_070528rs200678111
10CTRCp.Val250GluVAR_070538
11PRSS1p.Asn29IleVAR_006720rs111033566
12PRSS1p.Arg122HisVAR_006721rs267606982
13PRSS1p.Asp22GlyVAR_011652rs397507442
14PRSS1p.Lys23ArgVAR_011653rs111033567
15PRSS1p.Leu104ProVAR_011654
16PRSS1p.Arg116CysVAR_011655rs387906698
17PRSS1p.Cys139PheVAR_011656
18PRSS1p.Ala16ValVAR_011693rs202003805
19PRSS1p.Asn29ThrVAR_012712rs111033566
20PRSS1p.Arg122CysVAR_012713rs111033568
21PRSS1p.Asn54SerVAR_037908rs144422014
22PRSS1p.Glu79LysVAR_037909rs111033564
23SPINK1p.Leu14ProVAR_011688rs104893939
24SPINK1p.Asn34SerVAR_011689rs17107315
25SPINK1p.Leu12PheVAR_032011rs35877720

Clinvar genetic disease variations for Pancreatitis, Hereditary:

5 (show all 90)
id Gene Variation Type Significance SNP ID Assembly Location
1PRSS1NM_002769.4(PRSS1): c.365G> A (p.Arg122His)SNVPathogenicrs111033565GRCh37Chr 7, 142459789: 142459789
2PRSS1NM_002769.4(PRSS1): c.86A> T (p.Asn29Ile)SNVPathogenicrs111033566GRCh37Chr 7, 142458451: 142458451
3PRSS1NM_002769.4(PRSS1): c.68A> G (p.Lys23Arg)SNVPathogenicrs111033567GRCh37Chr 7, 142458433: 142458433
4PRSS1PRSS1, 3-BP DELdeletionPathogenicChr na, -1: -1
5PRSS1NM_002769.4(PRSS1): c.235G> A (p.Glu79Lys)SNVPathogenicrs111033564GRCh37Chr 7, 142459659: 142459659
6PRSS1NM_002769.4(PRSS1): c.161A> G (p.Asn54Ser)SNVPathogenicrs144422014GRCh37Chr 7, 142458526: 142458526
7PRSS1NM_002769.4(PRSS1): c.365_366delGCinsAT (p.Arg122His)indelPathogenicrs267606982GRCh37Chr 7, 142459789: 142459790
8PRSS1NM_002769.4(PRSS1): c.364C> T (p.Arg122Cys)SNVPathogenicrs111033568GRCh37Chr 7, 142459788: 142459788
9PRSS1PRSS1, TRIPLICATIONundetermined variantPathogenicChr na, -1: -1
10SPINK1NM_003122.4(SPINK1): c.194+2T> CSNVPathogenicrs148954387GRCh38Chr 5, 147828020: 147828020
11SPINK1NM_003122.4(SPINK1): c.150T> G (p.Asp50Glu)SNVPathogenicrs515726206GRCh38Chr 5, 147828066: 147828066
12SPINK1NM_003122.4(SPINK1): c.160T> C (p.Tyr54His)SNVPathogenicrs515726207GRCh38Chr 5, 147828056: 147828056
13SPINK1NM_003122.4(SPINK1): c.199C> T (p.Arg67Cys)SNVPathogenicrs515726208GRCh38Chr 5, 147824702: 147824702
14CFTRNM_000492.3(CFTR): c.54-5940_273+10250deldeletionPathogenicGRCh38Chr 7, 117498313: 117519392
15CFTRNM_000492.3(CFTR): c.3963-78_4242+577deldeletionPathogenicChr na, -1: -1
16CTRCNM_007272.2(CTRC): c.217G> A (p.Ala73Thr)SNVPathogenicrs515726209GRCh37Chr 1, 15767073: 15767073
17CTRCNM_007272.2(CTRC): c.738_761del24 (p.Lys247_Arg254del)deletionPathogenicrs515726210GRCh37Chr 1, 15772190: 15772213
18PRSS1NP_002760.1(PRSS1): p.Cys139Serprotein onlyPathogenicChr na, -1: -1
19SPINK1NM_003122.4(SPINK1): c.101A> G (p.Asn34Ser)SNVPathogenic, risk factorrs17107315GRCh37Chr 5, 147207678: 147207678
20SPINK1NM_003122.4(SPINK1): c.2T> C (p.Met1Thr)SNVPathogenicrs104893938GRCh37Chr 5, 147211139: 147211139
21SPINK1SPINK1, -215G-ASNVPathogenicChr na, -1: -1
22SPINK1NM_003122.4(SPINK1): c.41T> C (p.Leu14Pro)SNVPathogenicrs104893939GRCh37Chr 5, 147211100: 147211100
23SPINK1NM_003122.4(SPINK1): c.41T> G (p.Leu14Arg)SNVPathogenicrs104893939GRCh37Chr 5, 147211100: 147211100
24SPINK1SPINK1, 1.3-KB DELdeletionPathogenicChr na, -1: -1
25PRSS1NM_002769.4(PRSS1): c.347G> C (p.Arg116Pro)SNVLikely pathogenicrs199769221GRCh38Chr 7, 142751920: 142751920
26CFTRNM_000492.3(CFTR): c.850dupA (p.Met284Asnfs)duplicationLikely pathogenic, Pathogenicrs786204693GRCh37Chr 7, 117176708: 117176708
27CFTRNM_000492.3(CFTR): c.220C> T (p.Arg74Trp)SNVLikely pathogenicrs115545701GRCh37Chr 7, 117149143: 117149143
28CFTRNM_000492.3(CFTR): c.848_860delAAATGATTGAAAAinsTG (p.Lys283Metfs)indelPathogenicrs796065332GRCh37Chr 7, 117176706: 117176718
29CFTRNM_000492.3(CFTR): c.350G> A (p.Arg117His)SNV, HaplotypePathogenicrs78655421GRCh37Chr 7, 117171029: 117171029
30SPINK1NM_003122.4(SPINK1): c.56-37T> CSNVrisk factorrs17107318GRCh38Chr 5, 147829667: 147829667
31PRSS1NC_000007.14: g.(?_142749479)_(142752573_?)dupduplicationPathogenicGRCh38Chr 7, 142749479: 142752573
32CFTRNM_000492.3(CFTR): c.1210-7_1210-6delTTdeletionPathogenicrs727504486GRCh37Chr 7, 117188688: 117188689
33CFTRNM_000492.3(CFTR): c.1234_1238delGCAAA (p.Ala412Thrfs)deletionPathogenicrs3034796GRCh37Chr 7, 117188719: 117188723
34CFTRNM_000492.3(CFTR): c.3999delG (p.Lys1334Serfs)deletionPathogenicrs886042527GRCh37Chr 7, 117304777: 117304777
35CFTRNM_000492.3(CFTR): c.1679+1G> ASNVPathogenicrs397508263GRCh37Chr 7, 117227888: 117227888
36PRSS1NM_002769.4(PRSS1): c.346C> T (p.Arg116Cys)SNVPathogenicrs387906698GRCh37Chr 7, 142459770: 142459770
37CFTRNM_000492.3(CFTR): c.1865G> A (p.Gly622Asp)SNVPathogenicrs121908759GRCh37Chr 7, 117232086: 117232086
38CFTRNM_000492.3(CFTR): c.2051_2052delAAinsG (p.Lys684Serfs)indelPathogenicrs121908799GRCh37Chr 7, 117232272: 117232273
39CFTRNM_000492.3(CFTR): c.2052dupA (p.Gln685Thrfs)duplicationPathogenicrs121908786GRCh37Chr 7, 117232273: 117232273
40CFTRNM_000492.3(CFTR): c.2988G> A (p.Gln996=)SNVPathogenicrs121908797GRCh37Chr 7, 117246807: 117246807
41CFTRNM_000492.3(CFTR): c.3209G> A (p.Arg1070Gln)SNVLikely pathogenic, Pathogenicrs78769542GRCh37Chr 7, 117251704: 117251704
42CFTRNM_000492.3(CFTR): c.3454G> C (p.Asp1152His)SNVPathogenicrs75541969GRCh37Chr 7, 117254753: 117254753
43PRSS1NM_002769.4(PRSS1): c.389C> T (p.Thr130Ile)SNVLikely pathogenicrs193922655GRCh37Chr 7, 142459813: 142459813
44PRSS1NM_002769.4(PRSS1): c.398C> G (p.Pro133Arg)SNVLikely pathogenicrs193922656GRCh37Chr 7, 142459822: 142459822
45SPINK1NM_003122.4(SPINK1): c.163C> T (p.Pro55Ser)SNVPathogenicrs111966833GRCh37Chr 5, 147207616: 147207616
46SPINK1NM_003122.4(SPINK1): c.27delC (p.Ser10Valfs)deletionPathogenicrs193922659GRCh37Chr 5, 147211114: 147211114
47PRSS1NM_002769.4(PRSS1): c.116T> C (p.Val39Ala)SNVPathogenicrs397507439GRCh37Chr 7, 142458481: 142458481
48PRSS1NM_002769.4(PRSS1): c.415T> A (p.Cys139Ser)SNVPathogenicrs397507440GRCh37Chr 7, 142459839: 142459839
49PRSS1NM_002769.4(PRSS1): c.47C> T (p.Ala16Val)SNVPathogenicrs202003805GRCh37Chr 7, 142458412: 142458412
50PRSS1NM_002769.4(PRSS1): c.63_71dupTGACAAGAT (p.Ile24_Val25insAspLysIle)duplicationPathogenicrs397507441GRCh37Chr 7, 142458428: 142458436
51PRSS1NM_002769.4(PRSS1): c.65A> G (p.Asp22Gly)SNVPathogenicrs397507442GRCh37Chr 7, 142458430: 142458430
52PRSS1NM_002769.4(PRSS1): c.86A> C (p.Asn29Thr)SNVPathogenicrs111033566GRCh37Chr 7, 142458451: 142458451
53CFTRNM_000492.3(CFTR): c.3067_3072delATAGTG (p.Ile1023_Val1024del)deletionPathogenicrs121908767GRCh37Chr 7, 117250651: 117250656
54CFTRNM_000492.3(CFTR): c.579+1G> TSNVPathogenicrs77188391GRCh37Chr 7, 117174420: 117174420
55CFTRNM_000492.3(CFTR): c.2657+5G> ASNVPathogenicrs80224560GRCh37Chr 7, 117242922: 117242922
56CFTRNM_000492.3(CFTR): c.489+1G> TSNVPathogenicrs78756941GRCh37Chr 7, 117171169: 117171169
57CFTRNM_000492.3(CFTR): c.3302T> A (p.Met1101Lys)SNVPathogenicrs36210737GRCh37Chr 7, 117251797: 117251797
58CFTRNM_000492.3(CFTR): c.274-1G> ASNVPathogenicrs121908792GRCh37Chr 7, 117170952: 117170952
59CFTRNM_000492.3(CFTR): c.803delA (p.Asn268Ilefs)deletionPathogenicrs121908772GRCh37Chr 7, 117176661: 117176661
60CFTRNM_000492.3(CFTR): c.935_937delTCT (p.Phe312del)deletionPathogenicrs121908768GRCh37Chr 7, 117180219: 117180221
61CFTRNM_000492.3(CFTR): c.1327G> T (p.Asp443Tyr)SNVPathogenicrs147422190GRCh37Chr 7, 117188812: 117188812
62CFTRNM_000492.3(CFTR): c.165-1G> ASNVPathogenicrs397508249GRCh37Chr 7, 117149087: 117149087
63CFTRNM_000492.3(CFTR): c.1753G> T (p.Glu585Ter)SNVPathogenicrs397508296GRCh37Chr 7, 117230480: 117230480
64CFTRNM_000492.3(CFTR): c.1766+3A> GSNVPathogenicrs397508298GRCh37Chr 7, 117230496: 117230496
65CFTRNM_000492.3(CFTR): c.1853T> C (p.Ile618Thr)SNVPathogenicrs139468767GRCh37Chr 7, 117232074: 117232074
66CFTRNM_000492.3(CFTR): c.200C> T (p.Pro67Leu)SNVPathogenicrs368505753GRCh37Chr 7, 117149123: 117149123
67CFTRNM_000492.3(CFTR): c.2657+2_2657+3insAinsertionPathogenicrs397508414GRCh37Chr 7, 117242919: 117242920
68CFTRNM_000492.3(CFTR): c.2834C> T (p.Ser945Leu)SNVPathogenicrs397508442GRCh37Chr 7, 117243762: 117243762
69CFTRNM_000492.3(CFTR): c.3612G> A (p.Trp1204Ter)SNVPathogenicrs121908765GRCh37Chr 7, 117267719: 117267719
70CFTRNM_000492.3(CFTR): c.4426C> T (p.Gln1476Ter)SNVPathogenicrs374705585GRCh37Chr 7, 117307145: 117307145
71CFTRNM_000492.3(CFTR): c.577G> T (p.Glu193Ter)SNVPathogenicrs397508759GRCh37Chr 7, 117174417: 117174417
72CFTRNM_000492.3(CFTR): c.743+1G> ASNVPathogenicrs397508791GRCh37Chr 7, 117175466: 117175466
73CFTRNM_000492.3(CFTR): c.1521_1523delCTT (p.Phe508delPhe)deletionPathogenic, drug responsers113993960GRCh37Chr 7, 117199646: 117199648
74CFTRNM_000492.3(CFTR): c.1519_1521delATC (p.Ile507del)deletionPathogenicrs121908745GRCh37Chr 7, 117199644: 117199646
75CFTRNM_000492.3(CFTR): c.1624G> T (p.Gly542Ter)SNVPathogenicrs113993959GRCh37Chr 7, 117227832: 117227832
76CFTRNM_000492.3(CFTR): c.1652G> A (p.Gly551Asp)SNVPathogenic, drug responsers75527207GRCh37Chr 7, 117227860: 117227860
77CFTRNM_000492.3(CFTR): c.1657C> T (p.Arg553Ter)SNVPathogenicrs74597325GRCh37Chr 7, 117227865: 117227865
78CFTRNM_000492.3(CFTR): c.1675G> A (p.Ala559Thr)SNVPathogenicrs75549581GRCh37Chr 7, 117227883: 117227883
79CFTRNM_000492.3(CFTR): c.3846G> A (p.Trp1282Ter)SNVPathogenicrs77010898GRCh37Chr 7, 117282620: 117282620
80CFTRNM_000492.3(CFTR): c.1021_1022dupTC (p.Phe342Hisfs)duplicationPathogenicrs387906360GRCh37Chr 7, 117180305: 117180306
81CFTRNM_000492.3(CFTR): c.948delT (p.Phe316Leufs)deletionPathogenicrs121908744GRCh37Chr 7, 117180232: 117180232
82CFTRNM_000492.3: c.3718-2477C> TSNVPathogenicrs75039782GRCh37Chr 7, 117280015: 117280015
83CFTRNM_000492.3(CFTR): c.1438G> T (p.Gly480Cys)SNVPathogenicrs79282516GRCh37Chr 7, 117199563: 117199563
84CFTRNM_000492.3(CFTR): c.617T> G (p.Leu206Trp)SNVPathogenicrs121908752GRCh37Chr 7, 117175339: 117175339
85CFTRNM_000492.3(CFTR): c.3194T> C (p.Leu1065Pro)SNVPathogenicrs121909036GRCh37Chr 7, 117251689: 117251689
86CFTRNM_000492.3(CFTR): c.2988+1G> ASNVPathogenicrs75096551GRCh37Chr 7, 117246808: 117246808
87CFTRNM_000492.3(CFTR): c.2991G> C (p.Leu997Phe)SNVPathogenic, risk factorrs1800111GRCh37Chr 7, 117250575: 117250575
88CFTRNM_000492.3(CFTR): c.19G> T (p.Glu7Ter)SNVPathogenicrs121909045GRCh37Chr 7, 117120167: 117120167
89CTRCNM_007272.2(CTRC): c.760C> T (p.Arg254Trp)SNVPathogenic, risk factorrs121909293GRCh37Chr 1, 15772212: 15772212
90CTRCNM_007272.2(CTRC): c.164G> A (p.Trp55Ter)SNVPathogenic, risk factorrs121909294GRCh37Chr 1, 15767020: 15767020

Copy number variations for Pancreatitis, Hereditary from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
12208757141580825141583339Copy numberChronic pancreatitis

Expression for genes affiliated with Pancreatitis, Hereditary

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Search GEO for disease gene expression data for Pancreatitis, Hereditary.

Pathways for genes affiliated with Pancreatitis, Hereditary

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Pathways related to Pancreatitis, Hereditary according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
110.3CTRC, PRSS1
210.1CPA1, PRSS1, PRSS2
3
Show member pathways
10.1ELANE, PRSS1, PRSS2
410.0AP3B1, CD63, LAMP2
510.0CFTR, CPA1, PRSS1, PRSS2

GO Terms for genes affiliated with Pancreatitis, Hereditary

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Cellular components related to Pancreatitis, Hereditary according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1BLOC-3 complexGO:003108511.0HPS1, HPS4
2BLOC-2 complexGO:003108410.8HPS3, HPS5, HPS6
3lysosomal membraneGO:000576510.6AP3B1, CD63, CFTR, LAMP2
4lysosomeGO:000576410.3CD63, HPS1, HPS4, LAMP2, TYR
5melanosomeGO:004247010.2CD63, HPS4, TYR, TYRP1
6melanosome membraneGO:003316210.2DTNBP1, TYR, TYRP1
7extracellular spaceGO:000561510.2CD63, CPA1, ELANE, LAMP2, PRSS2, SCT
8platelet dense granule membraneGO:003108810.2CD63, LAMP2

Biological processes related to Pancreatitis, Hereditary according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cobalamin metabolic processGO:000923511.0CTRC, PRSS1
2anterograde axonal transportGO:000808910.9AP3B1, DTNBP1
3anterograde synaptic vesicle transportGO:004849010.9AP3B1, DTNBP1
4melanin biosynthetic processGO:004243810.9TYR, TYRP1
5melanocyte differentiationGO:003031810.8HPS4, HPS6, TYRP1
6extracellular matrix disassemblyGO:002261710.8ELANE, PRSS1, PRSS2
7melanosome organizationGO:003243810.8AP3B1, DTNBP1, TYRP1
8blood coagulationGO:000759610.6AP3B1, DTNBP1, HPS4, HPS5, HPS6
9organelle organizationGO:000699610.5DTNBP1, HPS3, HPS4, HPS5, HPS6
10pigmentationGO:004347310.3CD63, HPS3, HPS5, HPS6, TYR, TYRP1
11proteolysisGO:00065089.9CPA1, CTRC, ELANE, PRSS1, PRSS2

Molecular functions related to Pancreatitis, Hereditary according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1GTP-dependent protein bindingGO:003074210.8AP3B1, HPS6
2serine-type endopeptidase activityGO:000425210.0CTRC, ELANE, PRSS1, PRSS2

Sources for Pancreatitis, Hereditary

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet