Pancytopenia malady

Wikipedia: Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood...⁴⁴ more...

MalaCards: Pancytopenia, also known as pancytopenia nos (disorder), is related to fanconi's anemia and hemophagocytic lymphohistiocytosis. An important gene associated with Pancytopenia is DKC1 (dyskeratosis congenita 1, dyskerin), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics. The compounds cyclophosphamide and aspartate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, monocytes and t cells, and related mouse phenotypes are renal/urinary system and craniofacial.

Aliases & Descriptions:

pancytopenia 6 8 32 43 pancytopenia nos (disorder) 6

pancytopenia (disorder) 6 pancytopenia nos 6

Diseases related to pancytopenia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 386)

id	Related Disease	Score	Top Affiliating Genes
1	fanconi's anemia	30.7	FANCA, FANCC, FANCG
2	hemophagocytic lymphohistiocytosis	29.1	SH2D1A, RAB27A, IL2RA
3	dyskeratosis congenita	29.0	XIAP, IL3, DKC1, CSF2
4	paroxysmal nocturnal hemoglobinuria	28.9	PIGA, CD59, CD55, HP, CSF3
5	hemoglobinuria	27.7	PIGA, CD59, CD55, HP, WT1, TCN2
6	myeloproliferative disorder	27.5	MPL, MLL, IL3, THPO, CSF2, CSF3
7	splenomegaly	27.1	MPL, ITK, IL2RA, HP, THPO, CSF3
8	hepatoblastoma	27.0	MPL, IL3, THPO, CSF1, CSF3, EPO
9	toxic epidermal necrolysis	27.0	CD68, F13A1, CSF3
10	gaucher's disease	26.8	ACE, DHFR, CSF1, GBA
11	hairy cell leukemia	26.8	IL2RA, IL3, IFNG, CSF1, CSF2, CSF3
12	hepatitis c	26.6	IFNG, HP, THPO, AFP
13	viral hepatitis	25.5	IFNG, F3, HP, THPO, CSF3, CP
14	peripheral neuropathy	25.5	IL3, IFNG, ACE, CSF3, CP, AFP
15	crohn's disease	25.4	CD59, ITPA, IL2RA, IL3, IFNG, F13A1
16	t-cell leukemia	25.1	XIAP, CD59, CD55, MLL, IL2RA, IL3
17	neuropathy	24.7	IL2RA, IL3, IFNG, ACE, CSF1, CSF2
18	aplastic anemia	24.6	PIGA, SH2D1A, NBN, MPL, CD59, CD55
19	thrombocytopenia	23.6	PIGA, NAAA, MPL, ITK, ITPA, MGMT
20	glioblastoma	23.3	NBN, LIG4, XIAP, CD55, MGMT, IL2RA
21	twinning	22.5	RAB27A, MLL, FANCA, IFNG, F3, HP
22	cerebritis	21.9	XIAP, CD59, MGMT, IL3, IFNG, F3
23	thrombosis	21.8	PIGA, MPL, CD59, CD55, IL3, IFNG
24	hepatitis	19.3	PIGA, RAB27A, XIAP, CD59, CD68, CD55
25	immunodeficiency	18.2	SH2D1A, NBN, RAB27A, LIG4, XIAP, MPL
26	anemia	18.2	PIGA, SH2D1A, NBN, NAAA, LIG4, MPL
27	leukemia	16.3	PIGA, SH2D1A, NBN, LIG4, XIAP, MPL
28	essential thrombocythemia	13.7	MPL, THPO
29	myelofibrosis	13.7	MPL, THPO, EPO
30	chronic neutrophilic leukemia	13.7	MLL, CSF3
31	congenital amegakaryocytic thrombocytopenia	13.7	MPL, IL3, THPO
32	cyclic thrombocytopenia	13.7	IL3, THPO
33	leukemoid reaction	13.6	IL3, CSF2, CSF3
34	diamond-blackfan anemia	13.6	IL3, EPO
35	virus associated hemophagocytic syndrome	13.6	CD68, MLL, CSF3
36	felty's syndrome	13.6	IL3, CSF2, CSF3
37	iron metabolism disease	13.6	MPL, CP, EPO
38	granulocytopenia	13.6	IL3, CSF2, CSF3, CP
39	cyclic hematopoiesis	13.6	IL3, CSF1, CSF2, CSF3
40	iron deficiency anemia	13.6	THPO, CSF3, CP, EPO
41	hemosiderosis	13.5	PIGA, CP, EPO
42	acute myelomonocytic leukemia	13.5	MLL, IL3, CSF1, CSF3
43	al amyloidosis	13.5	CD68, IL3, CSF3
44	acute megakaryoblastic leukemia	13.5	MPL, MLL, IL3, CSF3
45	pulmonary alveolar proteinosis	13.5	IL3, CSF1, CSF2, CSF3
46	autoimmune thrombocytopenic purpura	13.5	NAAA, MPL, IL2RA, THPO
47	severe congenital neutropenia	13.5	IL3, CSF2, CSF3, EPO
48	hypersplenism	13.5	THPO, CSF2, CSF3, EPO, GBA
49	anemia of prematurity	13.5	CSF2, EPO
50	trichosporonosis	13.5	CBS, CSF3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pancytopenia:

²²

MGI Mouse Phenotypes related to pancytopenia:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	9.4	DKC1, WT1, CBS, MLL, CD55
2	craniofacial phenotype	MP:0005382	9.0	PIGA, NBN, LIG4, MLL, CBS, CSF1
3	respiratory system phenotype	MP:0005388	9.0	GBA, DKC1, F13A1, CBS, ITPA
4	embryogenesis phenotype	MP:0005380	8.9	CSF2, DKC1, CBS, FANCA, MLL, MPL
5	liver/biliary system phenotype	MP:0005370	8.8	GBA, EPO, CBS, IFNG, FANCC, MLL
6	endocrine/exocrine gland phenotype	MP:0005379	8.1	AFP, WT1, IFNG, FANCG, FANCC, FANCA
7	integument phenotype	MP:0010771	7.3	DKC1, CSF1, CSF2, CSF3, EPO, GBA
8	immune system phenotype	MP:0005387	7.0	GBA, SH2D1A, CSF2, DKC1, WT1, CBS
9	reproductive system phenotype	MP:0005389	6.7	CBS, WT1, DKC1, CSF1, CSF2, AFP
10	tumorigenesis	MP:0002006	6.5	F3, HP, ACE, DKC1, CSF2, AFP
11	hematopoietic system phenotype	MP:0005397	6.5	F13A1, FANCC, FANCA, IL3, ITPA, ITK
12	behavior/neurological phenotype	MP:0005386	6.5	CBS, ACE, CSF2, CP, GBA, F3
13	growth/size phenotype	MP:0005378	5.9	F3, CBS, TPMT, WT1, ACE, DKC1
14	cardiovascular system phenotype	MP:0005385	5.7	WT1, ACE, CSF1, CSF2, CP, EPO
15	homeostasis/metabolism phenotype	MP:0005376	4.4	HP, TPMT, WT1, ACE, DKC1, CSF1
16	mortality/aging	MP:0010768	3.6	CBS, F13A1, HP, TPMT, WT1, ACE
17	cellular phenotype	MP:0005384	3.5	CP, CSF2, CSF1, DKC1, ACE, WT1

Articles related to pancytopenia:

(show all 32)

id	Title	Authors	Year	Affiliating Genes
1	Prolonged and severe thrombocytopenia with pancytopenia induced by radiation-combined temozolomide therapy in a patient with newly diagnosed glioblastoma--analysis of O6-methylguanine-DNA methyltransferase status. (19037596)	Nagane M.... Shiokawa Y.	2009	MGMT
2	Transient severe pancytopenia due to elevated tumor necrosis factor-alpha in overwhelming infection. (19293548)	Tominaga T.... Shinohara K.	2009	IFNG, EPO
3	Pancytopenia complicated with peripheral neuropathy d ue to copper deficiency: clinical diagnostic review. (19043262)	Imataki O.... Tanaka T.	2008	CP
4	Paradoxical elevated thiopurine S-methyltransferase activity after pancytopenia during azathioprine therapy: potential influence of red blood cell age. (18520612)	de Boer N.K.... Van Kuilenburg A.B.	2008	TPMT
5	Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease. (16880012)	Gilissen L.P.... Engels L.G.	2007	ITPA, TPMT
6	Pancytopenia in untreated patients with Graves' disea se. (16646688)	Lima C.S.... Costa F.F.	2006	CSF3
7	Drug-induced toxic epidermal necrolysis and pancytopenia: a puzzling association. (15942674)	Paquet P.... Pierard G.E.	2005	F13A1, CD68
8	Spontaneous recovery from pancytopenia in a young female patient with paroxysmal nocturnal hemoglobinuria(PNH): changes in the GPI-anchor expression on peripheral blood cells (15103939)	Inukai T.... Nakazawa S.	2004	CD55, PIGA
9	Pancytopenia presenting with monosomy 7 which disappeared after immunosuppressive therapy. (14687628)	Nagasawa M.... Mizutani S.	2004	WT1
10	A rare syndrome in the differential diagnosis of hepa tosplenomegaly and pancytopenia: report of identical twins with Griscelli disea se. (12648328)	Sarper N.... Inan S.	2003	RAB27A
11	Girl with combined cellular immunodeficiency, pancytopenia, malformations, deletion 11q23.3 --> qter, and trisomy 8q24.3 --> qter. (11920839)	Ounap K.... Laidre P.	2002	MLL
12	Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor. (11895799)	Basser R.L.... Begley C.G.	2002	THPO
13	Severe pancytopenia from thiopurine methyltransferase deficiency: a preventable complication of 6-mercaptopurine therapy in children with Crohn disease. (12454589)	Rosen R.... Bousvaros A.	2002	TPMT
14	Colchicine induced toxicity and pancytopenia at usual doses and treatment with granulocyte colony-stimulating factor. (11361215)	Yoon K.H.	2001	CSF3
15	Early onset methotrexate-induced pancytopenia and response to G-CSF: a report of two cases. (17039083)	Yoon K.H.... Ng S.C.	2001	CSF3
16	Improvement of splenomegaly and pancytopenia by enzym e replacement therapy against type 1 Gaucher disease: a report of sibling cases . (11345203)	Tsuboi K.... Ueda R.	2001	GBA
17	'Emergency hepatectomy' in a 16-month-old boy with a hepatoblastoma, severe cytomegalovirus-induced pancytopenia, and intractable diarrhea. (9880755)	Benesch M.... Urban C.	1998	AFP
18	T cell-depleted granulocyte colony-stimulating factor (G-CSF) modified allogenic bone marrow transplantation for hematological malignancy improves graft CD34+ cell content but is associated with delayed pancytopenia. (9535034)	Mavroudis D.A.... Barrett A.J.	1998	CSF3
19	Copper deficiency with pancytopenia due to enteral nutrition through jejunostomy. (16844585)	Camblor M.... GarcA-a P.	1997	CP
20	Splenic vein thrombosis with pancytopenia and fever: antiphospholipid antibody syndrome (9522600)	Adducchio V.S.... Scoppio M.	1997	F3
21	Ticlopidine-associated pancytopenia: implications of an acetylsalicylic acid alternative. (9374946)	Gill S.... Armstrong P.W.	1997	CSF2
22	Allopurinol induced pancytopenia in a patient with myeloproliferative disorder (9028164)	Shinagawa A.... Abe T.	1997	CSF3, EPO
23	Azathioprine-induced severe pancytopenia due to a homozygous two- point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis. (9336428)	Leipold G.... Oellerich M.	1997	TPMT
24	The Recormon (recombinant erythropoietin) treatment of a patient with pancytopenia of the blood and chronic viral hepatitis C (9019832)	Lukina E.A.... Frank G.A.	1996	EPO
25	The Hoyeraal-Hreidarsson syndrome: the fourth case of a separate entity with prenatal growth retardation, progressive pancytopenia and cerebellar hypoplasia. (7607282)	Aalfs C.M.... Hennekam R.C.	1995	DKC1
26	Paroxysmal nocturnal hemoglobinuria clone in bone marrow of patients with pancytopenia. (7532041)	Nakakuma H.... Takatsuki K.	1995	CD55, CD59
27	Severe pancytopenia in old age after 12-month ACE in hibitor therapy (7519541)	Schratzlseer G.... Delius W.	1994	ACE
28	Evaluation of granulocyte-macrophage colony-stimulating factor for treatment of pancytopenia in children with fanconi anemia. (8283365)	Guinan E.C.... Nathan D.G.	1994	CSF2
29	Use of granulocyte colony-stimulating factor in the treatment of pancytopenia secondary to colchicine overdose. (1384817)	Katz R.... Sutton J.D.	1992	CSF3
30	Serum monocyte colony-stimulating factor, erythropoietin and interleukin-6 in relation to pancytopenia in hairy cell leukemia. (1625496)	Jansen J.H.... Kluin-Nelemans J.C.	1992	EPO, CSF1
31	Severe folate deficiency and pancytopenia in a nutrit ionally deprived infant and homocystinuria caused by cystathionine beta-synthas e deficiency. (2007933)	Wagstaff J.... Levy H.L.	1991	CBS
32	Acute pancytopenia induced by pyrimethamine during treatment of cerebral toxoplasmosis associated with AIDS. Role of dihydrofolate reductase inhibitors (2353761)	Boudes P.... Sobel A.	1990	DHFR

Genes related to pancytopenia according to GeneCards:

(show all 41)

id	Symbol	Description	Score	GeneCards Section Context
1	DKC1	dyskeratosis congenita 1, dyskerin	11.0	Publications
2	TPMT	thiopurine S-methyltransferase	11.0	Publications
3	TCN2	transcobalamin II	11.0
4	THPO	thrombopoietin	11.0	Publications
5	MPL	myeloproliferative leukemia virus oncogene	11.0
6	GBA	glucosidase, beta, acid	11.0	Publications
7	CP	ceruloplasmin (ferroxidase)	11.0	Publications
8	DHFR	dihydrofolate reductase	11.0	Publications
9	EPO	erythropoietin	11.0	Publications
10	MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	11.0	Publications
11	HP	haptoglobin	11.0
12	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
13	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
14	CSF1	colony stimulating factor 1 (macrophage)	11.0	Publications
15	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	11.0	Publications
16	IL2RA	interleukin 2 receptor, alpha	11.0
17	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0
18	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
19	SMR3B	submaxillary gland androgen regulated protein 3B	11.0	Disorders
20	MCEE	methylmalonyl CoA epimerase	11.0
21	NAAA	N-acylethanolamine acid amidase	11.0
22	CD68	CD68 molecule	11.0	Publications
23	FANCG	Fanconi anemia, complementation group G	11.0
24	PIGA	phosphatidylinositol glycan anchor biosynthesis, class A	11.0	Publications
25	SH2D1A	SH2 domain containing 1A	11.0
26	LIG4	ligase IV, DNA, ATP-dependent	11.0
27	ITPA	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)	11.0	Publications
28	ITK	IL2-inducible T-cell kinase	11.0
29	CD59	CD59 molecule, complement regulatory protein	11.0	Publications
30	FANCA	Fanconi anemia, complementation group A	11.0
31	RAB27A	RAB27A, member RAS oncogene family	11.0	Publications
32	CBS	cystathionine-beta-synthase	11.0	Publications
33	XIAP	X-linked inhibitor of apoptosis	11.0
34	NBN	nibrin	11.0
35	FANCC	Fanconi anemia, complementation group C	11.0
36	AFP	alpha-fetoprotein	11.0	Publications
37	F13A1	coagulation factor XIII, A1 polypeptide	11.0	Publications
38	WT1	Wilms tumor 1	11.0	Publications
39	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
40	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
41	IFNG	interferon, gamma	11.0	Publications

Pathways related to pancytopenia according to GeneDecks:

(show all 11)

id	Pathway	Score	Top Affiliating Genes
1	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.1	CSF2, IL2RA
2	Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics34	9.9	DHFR, TPMT, CBS, ITPA
3	Fanconi Anemia pathway38	9.8	FANCA, FANCC, FANCG
4	Fanconis Anaemia Pathway36	9.7	FANCG, FANCC, FANCA
5	DNA Repair Mechanisms36	9.4	FANCG, FANCC, FANCA, MGMT, LIG4
6	Hematopoietic cell lineage20	9.4	CD59, EPO, CSF3, CSF2, CSF1, THPO
7	Jak-STAT signaling pathway20	9.4	EPO, CSF3, CSF2, IFNG, IL3, IL2RA
8	PAK Pathway36	9.4	CSF3, CSF2, CSF1, THPO, IL3, IL2RA
9	JAK-STAT Pathway36	9.3	MPL, IL2RA, IL3, IFNG, THPO, EPO
10	Cytokine-cytokine receptor interaction20	9.2	EPO, CSF3, CSF2, CSF1, IFNG, IL3
11	Complement and coagulation cascades20	9.0	CD59, CD55, F3, F13A1

Compounds related to pancytopenia according to GeneDecks:

(show top 50)    (show all 164)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.6	PIGA, TPMT
2	aspartate32	10.2	CD55, MLL, HP
3	amifostine32 9 9	12.1	CSF2, CSF3, THPO, EPO, IL3
4	pixy32132	10.1	CSF3, CSF2, CSF1, THPO, IL3, EPO
5	molgramostim32	10.1	IL3, CSF3, CSF2, CSF1
6	filgrastim32 9 9	12.1	CSF3, CSF2, CSF1, THPO, EPO, IL3
7	vincristine32 34 9 9	13.0	AFP, CSF2, MGMT, MLL
8	pegfilgrastim32 9 9	11.9	EPO, CSF3, CSF2, IL3
9	rituximab32 34 9 9	12.7	CD59, CD55, IL2RA, CSF1, CSF2, XIAP
10	gp 13032	9.7	HP, THPO, CSF1, CSF2, IL2RA, IL3
11	cyclosporin a32 42	10.7	TPMT, HP, CD55, ITK, IL2RA, CD59
12	ifosfamide32 9 9	11.6	IL3, THPO, CSF1, CSF2, AFP, MGMT
13	melphalan32 9 9	11.6	CSF2, MGMT, FANCC, IFNG
14	h2o232	9.6	THPO, HP, CSF2, CBS, IL3, IL2RA
15	hydroxyurea32 9 9	11.6	EPO, CSF3, CSF1, DHFR, THPO, NBN
16	gm-csf32	9.6	CSF2, EPO, CSF1, THPO, IFNG, IL3
17	mycophenolate mofetil32 9 9	11.6	IL3, EPO, IL2RA, IFNG, TPMT, CSF3
18	etoposide32 42 9 9	12.5	MGMT, XIAP, MLL, IL3, THPO, CSF1
19	vitamin b1232	9.5	AFP, TCN2, EPO, MCEE, CP, CBS
20	zidovudine32 9 9	11.3	CSF3, CSF2, CSF1, EPO, DHFR, F3
21	cytarabine32 34 9 9	12.3	CSF3, DHFR, THPO, TPMT, CSF1, XIAP
22	folate32	9.2	IL2RA, MGMT, CBS, HP, TPMT, TCN2
23	azathioprine32 34 9 9	12.2	ITPA, MGMT, IL2RA, TPMT, EPO, AFP
24	cysteine32	9.2	CD55, XIAP, MPL, CP, GBA, IFNG
25	methylcellulose32	9.2	IFNG, THPO, CSF1, CD59, CSF3, EPO
26	ribavirin32 34 9 9	12.1	ITPA, AFP, CSF3, HP, IFNG, IL3
27	methotrexate32 34 42 9 9	13.0	DHFR, EPO, AFP, GBA, ITPA, MGMT
28	mitomycin c32	9.0	FANCG, FANCC, MGMT, NBN, XIAP, DHFR
29	valine32	9.0	AFP, CSF3, CSF1, DHFR, CSF2, IL3
30	estrogen32	8.9	F13A1, AFP, HP, MGMT, CP, WT1
31	lactate32	8.9	IL3, CSF2, CD59, AFP, EPO, CP
32	anti-fungal32	8.7	CSF2, CSF3, CSF1, DHFR, IFNG, AFP
33	doxorubicin32 34 9 9	11.7	IL2RA, AFP, WT1, CSF1, NBN, XIAP
34	carboplatin32 34 9 9	11.6	MGMT, CSF1, AFP, XIAP, EPO, CSF3
35	calcitriol32 42 9 18 9	12.6	CSF1, IL3, EPO, WT1, IFNG, IL2RA
36	polysaccharide32	8.5	IL3, GBA, AFP, CSF2, THPO, F3
37	5fluorouracil32	8.4	IFNG, XIAP, MPL, MGMT, IL2RA, IL3
38	cisplatin32 34 9 9	11.4	DHFR, MGMT, CD55, XIAP, EPO, AFP
39	aspirin32 34 18	10.3	CSF2, GBA, CD59, MPL, CSF1, THPO
40	heparin32 9 18 9	11.3	CD55, CSF2, CP, HP, F13A1, AFP
41	butyrate32	8.2	CSF1, AFP, EPO, IL3, XIAP, CD55
42	phosphatidylinositol32	8.2	THPO, CSF1, IL2RA, ITK, CD55, CD59
43	thymidine32 18	9.2	EPO, GBA, THPO, CSF3, MGMT, IL2RA
44	dexamethasone32 42 34 9 9	12.2	CP, THPO, CSF2, CSF1, IFNG, CSF3
45	actinomycin d32	8.0	IL3, XIAP, MLL, IFNG, F3, AFP
46	alanine32	8.0	FANCA, CD55, FANCG, IL3, HP, TPMT
47	creatinine32	7.3	EPO, AFP, THPO, CP, CSF1, CD55
48	tyrosine32	7.3	EPO, AFP, TPMT, WT1, CSF3, MLL
49	retinoic acid32 42 18	9.1	CSF2, MGMT, IL3, AFP, CSF3, CSF1
50	vegf32	6.6	CP, XIAP, CD55, MGMT, IL2RA, MPL

Cellular components related to pancytopenia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Fanconi anaemia nuclear complex	GO:043240	9.6	FANCA, FANCC, FANCG
2	extracellular space	GO:005615	6.5	IL3, AFP, EPO, CP, CSF3, CSF2

Biological processes related to pancytopenia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.8	IL3, CSF2, EPO
2	cell proliferation	GO:008283	9.3	NBN, CSF1, DKC1, THPO, IL2RA, MPL
3	positive regulation of cell proliferation	GO:008284	9.2	EPO, CSF3, CSF2, CSF1, THPO, IL3
4	DNA repair	GO:006281	8.9	FANCC, FANCA, MGMT, LIG4, NBN, FANCG

Molecular functions related to pancytopenia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:008083	9.8	IL3, THPO, CSF1, CSF2, CSF3
2	cytokine activity	GO:005125	9.0	IL3, CSF3, CSF2, CSF1, THPO, IFNG