MCID: PNC001
MIFTS: 55

Pancytopenia malady

Summaries for Pancytopenia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood... more...

MalaCards: Pancytopenia, also known as pancytopenia nos, is related to splenomegaly and arthritis. An important gene associated with Pancytopenia is TPMT (thiopurine S-methyltransferase), and among its related pathways are TGF-Beta Pathway and Rho Family GTPases. The compounds gm-csf and estrogen have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Pancytopenia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

pancytopenia 8 10 45 61
pancytopenia nos 8


External Ids:

Disease Ontology8 DOID:12450
MeSH35 D010198
ICD9CM27 284.1

Related Diseases for Pancytopenia

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Pancytopenia family:

pancytopenia due to ikzf1 mutations

Diseases related to Pancytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 315)
idRelated DiseaseScoreTop Affiliating Genes
1splenomegaly30.6HP, EPO, MPL, CSF3, GBA, IL2RA
2arthritis30.5CSF2, CSF1, CD55, HP
3tuberculosis30.5HP, DHFR, IL2RA, CP
4dyskeratosis congenita30.4DKC1, CSF2
5acute leukemia30.4TPMT, THPO, IL3, DHFR, EPO, MPL
6hepatitis c30.3HP, THPO
7aplastic anemia30.3CSF2, PIGA, CD55
8hypersplenism30.2THPO, GBA
9graves' disease30.2IL2RA, CD55
10megaloblastic anemia30.2TCN2, HP
11fanconi's anemia30.2THPO, IL3, DHFR, DKC1
12thrombocytopenia30.1GBA, HP, EPO, MPL, PIGA, MGMT
13vasculitis30.0TPMT
14hemophagocytic lymphohistiocytosis30.0IL2RA
15gaucher's disease30.0GBA
16hemoglobinuria30.0PIGA, CD55, HP, TCN2
17paroxysmal nocturnal hemoglobinuria30.0HP, CD55, PIGA, CSF3
18graft versus host disease30.0CSF2, CSF3, IL2RA, IL3
19systemic lupus erythematosus30.0MPL, CD55, IL2RA, TPMT
20deficiency anemia30.0CSF3, CSF2, PIGA, MPL, CD55, CP
21iron deficiency anemia29.9EPO, THPO
22congenital amegakaryocytic thrombocytopenia29.9THPO, IL3, MPL
23leukemoid reaction29.9CSF2, CSF3, IL3
24felty's syndrome29.9CSF2, CSF3, IL3
25primary hyperoxaluria29.9EPO, HP, THPO, TCN2
26refractory anemia29.9THPO, IL3, EPO, MPL, CSF1, CSF3
27hepatitis b29.7DHFR
28thalassemia29.7EPO
29nephritis29.7CD55
30acquired immunodeficiency syndrome29.7CSF2, DHFR
31acute graft versus host disease29.7THPO, IL2RA, CSF3
32autoimmune hemolytic anemia29.7HP, CD55, PIGA
33polycythemia vera29.7MPL, EPO, IL3, THPO
34capillary leak syndrome29.7CSF2
35t-cell leukemia29.7DHFR, IKZF1, IL2RA, IL3
36ulcerative colitis29.7CD55, IL2RA, THPO, TPMT
37myeloproliferative disorder29.7CSF2, CSF3, MPL, EPO, IL3, THPO
38thrombocytosis29.7CSF2, CSF3, MPL, EPO, HP, IL3
39myelodysplastic syndromes29.7CSF2, CSF3, CSF1, PIGA, MPL, CD55
40miliary tuberculosis10.3
41hepatitis a10.3
42sheehan syndrome10.2
43visceral leishmaniasis10.2
44thymoma10.2
45cerebellar hypoplasia10.2
46hereditary spherocytosis10.1
47subacute bacterial endocarditis10.1
48micro syndrome10.1
49microcephaly10.0
50anorexia nervosa10.0

Graphical network of the top 20 diseases related to Pancytopenia:



Diseases related to pancytopenia

Clinical Features for Pancytopenia

Drugs & Therapeutics for Pancytopenia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Pancytopenia

Search NIH Clinical Center for Pancytopenia

Search CenterWatch for Pancytopenia

Genetic Tests for Pancytopenia

Anatomical Context for Pancytopenia

Sources:
33MalaCards
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MalaCards organs/tissues related to Pancytopenia:

33
Skin, Ovary, Liver, Spinal cord, Kidney, Lymph node, Lung, Spleen, Bone marrow, Whole blood, Heart, Colon, Pancreas, Thyroid, Breast, Myeloid, Monocytes, T cells, B lymphoblasts, B cells

Animal Models for Pancytopenia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Pancytopenia

Sources:
51PubMed
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Articles related to Pancytopenia:

(show top 50)    (show all 553)
idTitleAuthorsYear
1
Neonatal pancytopenia associated with de novo 1q43-44 deletion and 10p15 duplication. (23337548)
2013
2
Pancytopenia following vivax malaria in a CLL patient. (24344451)
2013
3
Demonstration of early functional compromise of bone marrow derived hematopoietic progenitor cells during bovine neonatal pancytopenia through in vitro culture of bone marrow biopsies. (23110710)
2012
4
Successful use of tocilizumab in a patient with rheumatoid arthritis following severe pancytopenia during etanercept therapy. (21946465)
2011
5
Sheehan's syndrome with pancytopenia: a case report and review of the literature. (21968051)
2011
6
Helicobacter pylori infection-related pancytopenia in a young boy. (21728722)
2011
7
A 15-month-old girl with fever and pancytopenia. (22170136)
2011
8
Reversible pancytopenia following the consumption of decoction of Ganoderma neojaponicum Imazeki. (21370949)
2011
9
Sera from dams of calves with bovine neonatal pancytopenia contain alloimmune antibodies directed against calf leukocytes. (21440315)
2011
10
Pancytopenia and nephrotic syndrome related to autoimmune hypothyroidism. (21912731)
2011
11
Iron deficiency anemia presenting as pancytopenia in an adolescent girl. (21721367)
2011
12
Sudden-onset pancytopenia with intracranial hemorrhage after oxaliplatin treatment: a case report and literature review. (20826449)
2011
13
Dyspnea, pancytopenia, and splenomegaly. (21977486)
2011
14
Possible preventive strategy for bovine neonatal pancytopenia. (21257514)
2010
15
Pancytopenia due to proguanil toxicity in a returning traveller with fever. (20407763)
2010
16
Recurrent idiopathic acute hepatitis-associated aplastic anemia/pancytopenia fourteen years after initial episode. (21057169)
2010
17
Perioperative management for a patient with chronic pancytopenia: a case of aplastic anemia with persistent neutropenia following preoperative administration of G-CSF. (20094735)
2010
18
Autoimmune pancytopenia following combination chemotherapy for chronic lymphocytic leukaemia. (19398596)
2009
19
Childhood cerebral vivax malaria with pancytopenia. (19194195)
2009
20
Pancytopenia in a simultaneous pancreas and kidney transplant recipient: an unexpected cause - a case of visceral leishmaniasis in a transplant recipient. (19356384)
2009
21
A multicenter retrospective study defining the clinical and hematological manifestations of brucellosis and pancytopenia in a large series: Hematological malignancies, the unusual cause of pancytopenia in patients with brucellosis. (18069671)
2008
22
Etiological spectrum of pancytopenia based on bone marrow examination in children. (18460245)
2008
23
Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice. (17283043)
2007
24
Oxaliplatin-induced immune pancytopenia. (15847658)
2005
25
Fatal immune-mediated pancytopenia and a TRALI-like syndrome associated with high titers of recipient-type antibodies against donor-derived peripheral blood cells after allogeneic bone marrow transplantation following dose reduced conditioning. (15136241)
2004
26
Transient pancytopenia preceding T lineage acute lymphoblastic leukemia. (15345901)
2004
27
A child with vitamin B12 deficiency presenting with pancytopenia and hyperpigmentation. (15591907)
2004
28
A young woman with fever and pancytopenia. (14506825)
2003
29
Bloody diarrhea, fever, and pancytopenia in a patient with active ulcerative colitis. (12722958)
2003
30
Pel-Ebstein fever with cyclical pancytopenia. (11234207)
2001
31
Pyrexia and pancytopenia with unusual host immune response. (10727577)
2000
32
Pancytopenia due to hemophagocytic syndrome as the presenting manifestation of tuberculosis. (11273486)
2000
33
Aplastic pancytopenia associated with thymoma. (11131928)
2000
34
Pancytopenia--a clinico-hematologic analysis of 77 cases. (11127368)
1999
35
Pancytopenia in Zimbabwe. (9892268)
1999
36
Bilateral renal agenesis, cardiac hypertrophy and pancytopenia, a new syndrome? (9823496)
1998
37
Pancytopenia secondary to oxalosis in a 23-year-old woman. (9596694)
1998
38
Antithymocyte globulin for a patient with systemic lupus erythematosus complicated by severe pancytopenia. (9283997)
1997
39
Azathioprine-induced severe pancytopenia due to a homozygous two- point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis. (9336428)
1997
40
Cyclosporin-responsive pancytopenia and HLA class II alleles of a patient with paroxysmal nocturnal hemoglobinuria. (8867728)
1996
41
Serum monocyte colony-stimulating factor, erythropoietin and interleukin-6 in relation to pancytopenia in hairy cell leukemia. (1625496)
1992
42
Severe folate deficiency and pancytopenia in a nutritionally deprived infant and homocystinuria caused by cystathionine beta-synthase deficiency. (2007933)
1991
43
Acute pancytopenia induced by pyrimethamine during treatment of cerebral toxoplasmosis associated with AIDS. Role of dihydrofolate reductase inhibitors]. (2353761)
1990
44
Marrow transplantation for pancytopenia in dyskeratosis congenita. (3893572)
1985
45
Dyskeratosis congenita with pancytopenia and horseshoe kidney. (6710212)
1984
46
Pancytopenia associated with a granulosa-cell tumor of the ovary. Report of a case. (1258825)
1976
47
DYSKERATOSIS CONGENITA AND FAMILIAL PANCYTOPENIA. (14270277)
1965
48
Erythrokinetic studies in primary hypersplenism with pancytopenia. (13898144)
1962
49
Congenital hypersplenism with pancytopenia and basophilic stippling: therapeutic failure of ACTH and splenectomy. (13114816)
1954
50
Hypersplenism, an unusual case of splenic pancytopenia secondary to Gaucher's disease in an adult. (14824747)
1951

Genetic Variations for Pancytopenia

Expression for genes affiliated with Pancytopenia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancytopenia

Search GEO for disease gene expression data for Pancytopenia.

Pathways for genes affiliated with Pancytopenia

Sources:
52QIAGEN, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Pancytopenia

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience
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Compounds related to Pancytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1gm-csf45 2911.8THPO
2estrogen4510.7THPO
3dexamethasone45 50 29 1113.4MGMT, CD55, IKZF1, IL3
4anagrelide45 1111.4CSF2, MPL, EPO, THPO
5molgramostim4510.3CSF2, CSF3, CSF1, IL3
6pegfilgrastim45 1111.3CSF2, CSF3, EPO, IL3
7butyrate4510.3CSF2, CSF1, DHFR, THPO
8mafosfamide4510.3CSF2, CSF3, IL3, THPO
9diethyl dithiocarbamate4510.2CSF1, EPO, DHFR, IL2RA, TPMT
10amifostine45 1111.2CSF2, CSF3, EPO, IL3, THPO
11pixy3214510.1CSF2, CSF3, CSF1, EPO, IL3, THPO
12leucovorin45 50 1112.1THPO, IL3, DHFR, CSF3, CSF2
13filgrastim45 1111.1CSF2, CSF3, CSF1, EPO, IL3, THPO
14mycophenolate mofetil45 50 1112.1CSF3, EPO, IL2RA, IL3, TPMT
15paclitaxel45 50 1112.1CSF3, CSF1, DHFR, IL3
16ifosfamide45 1111.1CSF2, CSF3, CSF1, MGMT, IL3, THPO
17ribavirin45 50 1112.1CSF2, CSF3, EPO, HP, IL3
18zidovudine45 1111.0CSF2, CSF3, CSF1, EPO, DHFR, IL3
19rituximab45 50 1112.0CSF2, CSF3, CSF1, CD55, HP, IL2RA
20aspirin45 50 29 2413.0CSF2, CSF1, MPL, HP, GBA, IL2RA
21n-formylmethionyl-leucylphenylalanine4510.0CSF2, CSF3, CSF1, CD55, IL3
22hydroxyurea45 50 1112.0CSF2, CSF3, CSF1, EPO, DHFR, IL3
23methylcellulose4510.0CSF2, CSF3, CSF1, PIGA, EPO, IL3
24creatinine4510.0CSF1, CD55, EPO, HP, THPO, TCN2
25methotrexate45 50 1111.9CSF3, MGMT, EPO, GBA, DHFR, IL2RA
26cytarabine45 50 1111.9CSF2, CSF3, CSF1, EPO, DHFR, IL3
27ascorbic acid45 2410.9CSF1, EPO, HP, DHFR, IL2RA, IL3
28carboplatin45 50 1111.9IL3, HP, EPO, MGMT, CSF1, CSF3
29polysaccharide459.9CSF2, CD55, HP, GBA, IL2RA, IL3
30folate459.9MGMT, EPO, HP, DHFR, IKZF1, IL2RA
31melphalan45 1110.8CSF2, CSF3, MGMT, EPO, IL3
32heparin45 29 11 2412.8CSF2, CSF1, CD55, HP, IL2RA, THPO
33neopterin459.8CSF2, CSF1, HP, IL2RA, IL3
34etoposide45 50 60 1112.8CSF2, CSF3, CSF1, MGMT, DHFR, IL2RA
35gp 130459.8IL3, IL2RA, HP, EPO, MPL, CSF1
36lactate459.8CSF2, CSF1, MGMT, EPO, HP, DHFR
37cyclosporin a45 29 6011.8CSF3, CD55, EPO, HP, IL2RA, IL3
38histamine45 29 2411.7CSF2, CSF1, CD55, IL2RA, IL3, THPO
39cyclophosphamide45 50 1111.7CSF2, CSF3, TPMT, IL3, IL2RA, DHFR
40thymidine45 2410.7CSF2, CSF3, CSF1, MGMT, EPO, GBA
41alanine459.7CSF1, MPL, CD55, HP, DHFR, IKZF1
425fluorouracil459.7TPMT, CSF2, THPO, IL3, IL2RA, DHFR
43adenylate459.7CSF1, HP, GBA, DHFR, IL2RA, IL3
44cisplatin45 50 60 1112.6CSF2, CSF3, CSF1, MGMT, CD55, EPO
45fmlp459.6CSF2, CSF3, CSF1, CD55, IL3, THPO
46neomycin459.6CSF1, EPO, GBA, DHFR, IL3
47doxorubicin45 50 1111.5IL3, IL2RA, DHFR, MGMT, CSF1, CSF3
48phosphatidylinositol459.5CSF2, CSF1, PIGA, MPL, CD55, EPO
49vegf459.5CSF2, CSF3, CSF1, MGMT, MPL, CD55
50cysteine459.4CD55, MPL, MGMT, CSF1, CSF2, HP

GO Terms for genes affiliated with Pancytopenia

Sources:
16Gene Ontology
See all sources

Cellular components related to Pancytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.6CD55, EPO, HP, IL3, TCN2, CP
2extracellular spaceGO:0056159.1CP, CSF2, CSF3, CSF1, EPO, HP

Biological processes related to Pancytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of Ras protein signal transductionGO:04657910.2EPO, CSF1
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.2IL3, EPO, CSF2
3positive regulation of DNA replicationGO:04574010.1IL3, EPO, CSF2
4positive regulation of macrophage derived foam cell differentiationGO:0107449.9CSF1, CSF2
5cell proliferationGO:0082839.9CSF1, MPL, DKC1, IL2RA, THPO
6positive regulation of cell proliferationGO:0082849.7CSF2, CSF3, CSF1, EPO, IL3

Molecular functions related to Pancytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.8CSF3, CSF1, IL3, THPO, CSF2
2growth factor activityGO:0080839.5THPO, IL3, CSF1, CSF3, CSF2

Products for genes affiliated with Pancytopenia

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Sources for Pancytopenia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet