MCID: PNC001
MIFTS: 41

Pancytopenia malady

Blood diseases, Rare diseases, Immune diseases categories

Summaries for Pancytopenia

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Wikipedia:63 Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood... more...

MalaCards based summary: Pancytopenia, also known as pancytopenia nos, is related to splenomegaly and aplastic anemia. An important gene associated with Pancytopenia is TPMT (thiopurine S-methyltransferase), and among its related pathways is One carbon pool by folate. The compounds uridine and 5fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and liver, and related mouse phenotypes are cellular and immune system.

Aliases & Classifications for Pancytopenia

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH, 27ICD9CM
See all sources

Pancytopenia, Aliases & Descriptions:

Name: Pancytopenia 9 11 43 60
 
Pancytopenia Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases, Immune diseases


External Ids:

Disease Ontology9 DOID:12450
MeSH33 D010198
ICD9CM27 284.1

Related Diseases for Pancytopenia

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Diseases in the Pancytopenia family:

Pancytopenia Due to Ikzf1 Mutations

Diseases related to Pancytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 262)
idRelated DiseaseScoreTop Affiliating Genes
1splenomegaly30.5GBA, MPL
2aplastic anemia30.5DKC1, MPL
3neutropenia30.0MPL, TPMT
4thrombocytopenia29.9TPMT, MPL, GBA
5leukemia29.6GBA, MPL, TPMT, IKZF1, TCN2
6deficiency anemia29.3TCN2, GBA, MPL, TPMT
7arthritis10.4
8hepatitis10.4
9dyskeratosis congenita10.4
10rheumatoid arthritis10.4
11brucellosis10.4
12myelodysplastic syndrome10.3
13tuberculosis10.3
14fanconi anemia, complementation group a10.3
15miliary tuberculosis10.3
16vitamin b12 deficiency10.3
17lupus erythematosus10.2
18malaria10.2
19graves' disease10.2
20thymoma10.2
21myelofibrosis10.2
22hypersplenism10.2
23visceral leishmaniasis10.2
24megaloblastic anemia10.2
25hyperthyroidism10.2
26leishmaniasis10.2
27crohn's disease10.1
28hepatitis b10.1
29hereditary spherocytosis10.1
30subacute bacterial endocarditis10.1
31endocarditis10.1
32lymphoblastic leukemia10.1
33peritonitis10.1
34pneumonia10.1
35cerebellar hypoplasia10.1
36myelocerebellar disorder10.1
37acute lymphoblastic leukemia, childhood10.1TPMT, IKZF1
38systemic lupus erythematosus10.1
39breast cancer10.1
40anorexia nervosa10.1
41hemophagocytic lymphohistiocytosis10.1
42microcephaly10.1
43histoplasmosis10.1
44vasculitis10.1
45bone marrow necrosis10.1
46fanconi like syndrome10.1
47cytomegalovirus infection10.1
48pancytopenia due to ikzf1 mutations10.1
49pancytopenia-developmental delay syndrome10.1
50acute leukemia10.1MPL, TPMT

Graphical network of the top 20 diseases related to Pancytopenia:



Diseases related to pancytopenia

Symptoms for Pancytopenia

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Drugs & Therapeutics for Pancytopenia

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Drug clinical trials:

Search ClinicalTrials for Pancytopenia

Search NIH Clinical Center for Pancytopenia

Genetic Tests for Pancytopenia

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Anatomical Context for Pancytopenia

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MalaCards organs/tissues related to Pancytopenia:

31
Bone, Bone marrow, Liver, Kidney, T cells, Breast, Myeloid, B cells, Spleen, Pancreas, Thyroid, Monocytes, Whole blood, Lymph node, Spinal cord, Heart, Colon, Lung, Skin, Ovary, Pituitary

Animal Models for Pancytopenia or affiliated genes

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MGI Mouse Phenotypes related to Pancytopenia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.2IKZF1, DKC1, MPL, GBA
2MP:00053877.9GBA, MPL, DKC1, IKZF1
3MP:00053977.8GBA, MPL, TPMT, DKC1, IKZF1
4MP:00053787.7GBA, MPL, TPMT, DKC1, IKZF1
5MP:00107687.6IKZF1, DKC1, TPMT, MPL, GBA

Publications for Pancytopenia

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Articles related to Pancytopenia:

(show top 50)    (show all 585)
idTitleAuthorsYear
1
A case of recurrent pancytopenia in a patient with acute promyelocytic leukemia on maintenance chemotherapy and concomitant methyltetrahydrofolate reductase and thiopurine S-methyltransferase mutationa88-a88review of literature. (25791511)
2015
2
Pancytopenia related to malnutrition during pregnancy. (25887943)
2015
3
Dyskeratosis congenita caused by a novel TERT point mutation in siblings with pancytopenia and exudative retinopathy. (25067791)
2014
4
Pancytopenia from severe cobalamin (vitamin B12) deficiency in Johanson-Blizzard syndrome. (23900243)
2013
5
Unremitting pyrexia, pancytopenia, hepatosplenomegaly, and extreme hyperferritinemia. (23495040)
2013
6
A 13-year-old girl with pancytopenia. Catastrophic antiphospholipid syndrome. (23556525)
2013
7
The common causes leading to pancytopenia in patients presenting to tertiary care hospital. (24353701)
2013
8
Congenital amegakaryocytic thrombocytopenia (CAMT) presenting as severe pancytopenia in the first month of life. (23625800)
2013
9
Calf-level factors associated with bovine neonatal pancytopenia - a multi-country case-control study. (24312485)
2013
10
Imported case of visceral leishmaniasis presenting as pancytopenia in a Norwegian patient treated with methotrexate and etanercept for psoriasis arthritis. (22886470)
2013
11
Hematologic Recovery of Pancytopenia after Treatment of Hashimoto's Thyroiditis and Primary Adrenal Insufficiency. (23626971)
2013
12
Clinical and magnetic resonance imaging (MRI) findings of idiopathic aplastic pancytopenia in a dog treated with cyclosporine and azathioprine. (23024391)
2012
13
Parvovirus B19 presenting with persistent pancytopenia in a patient of T-ALL post induction chemotherapy diagnosed on bone marrow examination. (21934234)
2011
14
Successful use of tocilizumab in a patient with rheumatoid arthritis following severe pancytopenia during etanercept therapy. (21946465)
2011
15
Spontaneous tumor lysis syndrome with resolution of pancytopenia and disappearance of lymphadenopathy in a patient with peripheral T cell lymphoma unspecified. (21347646)
2011
16
Fulminant pancytopenia due to cytomegalovirus infection in an immunocompetent adult. (20563446)
2010
17
Amiodarone-induced bone marrow granulomas: an unusual cause of reversible pancytopenia. (22184519)
2010
18
Pancytopenia in hospitalized children: a five-year review. (20523248)
2010
19
Acute severe pancytopenia associated with clopidogrel. (19367789)
2009
20
Unusual pancytopenia secondary to haemophagocytosis syndrome in rickettsioses. (19446860)
2009
21
Fatal pancytopenia in a hemodialysis patient after treatment with low-dose methotrexate. (19502905)
2009
22
A 15-year-old girl with pancytopenia and congenital defects. (19584579)
2009
23
A study of clinico-haematological profiles of pancytopenia in children. (18820199)
2008
24
Enoxaparin-induced reversible pancytopenia. (17911201)
2007
25
Apparent vaccine-thimerosal induced hypersensitivity, myelodysplastic syndrome and pancytopenia. (19734619)
2007
26
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease. (16880012)
2007
27
The incidence of pancytopenia in patients taking leflunomide alone or with methotrexate. (16634119)
2007
28
A 14-year-old girl with pancytopenia. (16493913)
2006
29
Serious pancytopenia from methotrexate treatment of psoriatic arthritis. (16635735)
2006
30
Pancytopenia in untreated patients with Graves' disease. (16646688)
2006
31
Metastatic malignant melanoma presenting as pancytopenia in a three-year-old boy. (15800910)
2005
32
Systemic lupus erythematosus presenting with pancytopenia due to bone marrow myelofibrosis in a 22-year-old male. (16163223)
2004
33
Fatal immune-mediated pancytopenia and a TRALI-like syndrome associated with high titers of recipient-type antibodies against donor-derived peripheral blood cells after allogeneic bone marrow transplantation following dose reduced conditioning. (15136241)
2004
34
A case report of pancytopenia with quetiapine use. (14609812)
2003
35
Challenges with linezolid therapy and reversible pancytopenia. (12811516)
2003
36
A young woman with fever and pancytopenia. (14506825)
2003
37
Girl with combined cellular immunodeficiency, pancytopenia, malformations, deletion 11q23.3 --> qter, and trisomy 8q24.3 --> qter. (11920839)
2002
38
Methotrexate-induced pancytopenia and death in the Japanese literature. (24383840)
2002
39
Colchicine induced toxicity and pancytopenia at usual doses and treatment with granulocyte colony-stimulating factor. (11361215)
2001
40
Pancytopenia and colitis with Clostridium difficile in a rheumatoid arthritis patient taking methotrexate, antibiotics and non-steroidal anti-inflammatory drugs. (11254248)
2001
41
Pancytopenia after treatment of keratoacanthoma by single lesional methotrexate infiltration. (11493112)
2001
42
Pyrexia and pancytopenia with unusual host immune response. (10727577)
2000
43
Lethal pancytopenia associated with chilblain lupus erythematosus. (11200851)
2000
44
Fever, rash, and pancytopenia following vancomycin rechallenge in the presence of ceftazidime. (10676837)
2000
45
Severe pancytopenia after leflunomide in rheumatoid arthritis. (10989684)
2000
46
Bilateral renal agenesis, cardiac hypertrophy and pancytopenia, a new syndrome? (9823496)
1998
47
Thymoma-associated pancytopenia: effectiveness of cyclosporine A. (9829850)
1998
48
"Emergency hepatectomy" in a 16-month-old boy with a hepatoblastoma, severe cytomegalovirus-induced pancytopenia, and intractable diarrhea. (9880755)
1998
49
Serum monocyte colony-stimulating factor, erythropoietin and interleukin-6 in relation to pancytopenia in hairy cell leukemia. (1625496)
1992
50
Inhibition of bone marrow stem cell growth in vitro by methylmalonic acid: a mechanism for pancytopenia in a patient with methylmalonic acidemia. (7254944)
1981

Variations for Pancytopenia

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Expression for genes affiliated with Pancytopenia

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Search GEO for disease gene expression data for Pancytopenia.

Pathways for genes affiliated with Pancytopenia

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Pathways related to Pancytopenia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
One Carbon Metabolism36
dTMP de novo biosynthesis (mitochondrial)36
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate36
Trans-sulfuration and one carbon metabolism36
methionine salvage36
Methionine metabolism58
9.4TCN2, TPMT

Compounds for genes affiliated with Pancytopenia

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Sources:
43Novoseek, 24HMDB, 12DrugBank, 49PharmGKB, 28IUPHAR
See all sources

Compounds related to Pancytopenia according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1uridine43 24 1211.7DKC1, TPMT
25fluorouracil439.5TPMT, MPL
3folate439.0IKZF1, TCN2, TPMT
4aspirin43 49 28 2412.0MPL, GBA
5alanine439.0MPL, TPMT, IKZF1
6methotrexate49 43 1210.9TPMT, GBA

GO Terms for genes affiliated with Pancytopenia

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Cellular components related to Pancytopenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lysosomal lumenGO:00432029.0TCN2, GBA

Biological processes related to Pancytopenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to testosteroneGO:00335749.2TPMT, GBA

Products for genes affiliated with Pancytopenia

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Sources for Pancytopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet