MCID: PNC001
MIFTS: 48

Pancytopenia malady

Blood diseases, Rare diseases, Immune diseases categories

Summaries for Pancytopenia

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood... more...

MalaCards: Pancytopenia, also known as pancytopenia nos, is related to splenomegaly and leukemia. An important gene associated with Pancytopenia is TPMT (thiopurine S-methyltransferase), and among its related pathways is One carbon pool by folate. The compounds uridine and 5fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney, and related mouse phenotypes are cellular and immune system.

Aliases & Classifications for Pancytopenia

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT, 28ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases, Immune diseases


Aliases & Descriptions:

pancytopenia 9 11 46 63
pancytopenia nos 9


External Ids:

Disease Ontology9 DOID:12450
MeSH36 D010198
ICD9CM28 284.1

Related Diseases for Pancytopenia

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Pancytopenia family:

Pancytopenia Due to Ikzf1 Mutations

Diseases related to Pancytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 241)
idRelated DiseaseScoreTop Affiliating Genes
1splenomegaly30.6GBA, MPL
2leukemia30.4GBA, MPL, TPMT, IKZF1, TCN2
3aplastic anemia30.3DKC1, MPL
4thrombocytopenia30.0TPMT, MPL, GBA
5deficiency anemia29.8TCN2, GBA, MPL, TPMT
6neutropenia29.7MPL, TPMT
7arthritis10.4
8hepatitis10.4
9rheumatoid arthritis10.4
10brucellosis10.3
11tuberculosis10.3
12myelodysplastic syndromes10.3
13dyskeratosis congenita10.3
14miliary tuberculosis10.3
15lupus erythematosus10.2
16vitamin b12 deficiency10.2
17hypersplenism10.2
18fanconi's anemia10.2
19visceral leishmaniasis10.2
20megaloblastic anemia10.2
21leishmaniasis10.2
22malaria10.2
23myelofibrosis10.2
24thymoma10.2
25cerebellar hypoplasia10.2
26hereditary spherocytosis10.1
27hepatitis b10.1
28subacute bacterial endocarditis10.1
29graves' disease10.1
30endocarditis10.1
31hyperthyroidism10.1
32lymphoblastic leukemia10.1
33peritonitis10.1
34pneumonia10.1
35graft versus host disease10.1
36crohn's disease10.1
37microcephaly10.1
38hemoglobinuria10.1
39anorexia nervosa10.1
40hemophagocytic lymphohistiocytosis10.1
41systemic lupus erythematosus10.1
42breast cancer10.1
43histoplasmosis10.1
44vasculitis10.1
45shwachman-diamond syndrome10.1
46bone marrow necrosis10.1
47myelocerebellar disorder10.1
48paroxysmal nocturnal hemoglobinuria10.1
49acute lymphoblastic leukemia, childhood10.0TPMT, IKZF1
50acute leukemia10.0MPL, TPMT

Graphical network of the top 20 diseases related to Pancytopenia:



Diseases related to pancytopenia

Symptoms for Pancytopenia

About this section

Drugs & Therapeutics for Pancytopenia

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pancytopenia

Drug clinical trials:

Search ClinicalTrials for Pancytopenia

Search NIH Clinical Center for Pancytopenia

Search CenterWatch for Pancytopenia

Genetic Tests for Pancytopenia

About this section

Anatomical Context for Pancytopenia

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Pancytopenia:

34
Bone, Bone marrow, Kidney, T cells, Liver, Myeloid, Breast, B cells, Monocytes, Pancreas, Thyroid, Spleen, Colon, Whole blood, Lymph node, Ovary, Skin, Spinal cord, Heart, Lung

Animal Models for Pancytopenia or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Pancytopenia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.2IKZF1, DKC1, MPL, GBA
2MP:00053877.9GBA, MPL, DKC1, IKZF1
3MP:00053977.8GBA, MPL, TPMT, DKC1, IKZF1
4MP:00053787.7GBA, MPL, TPMT, DKC1, IKZF1
5MP:00107687.6IKZF1, DKC1, TPMT, MPL, GBA

Publications for Pancytopenia

About this section
Sources:
53PubMed
See all sources

Articles related to Pancytopenia:

(show top 50)    (show all 542)
idTitleAuthorsYear
1
Pancytopenia from severe cobalamin (vitamin B12) deficiency in Johanson-Blizzard syndrome. (23900243)
2013
2
Unremitting pyrexia, pancytopenia, hepatosplenomegaly, and extreme hyperferritinemia. (23495040)
2013
3
A 13-year-old girl with pancytopenia. Catastrophic antiphospholipid syndrome. (23556525)
2013
4
The common causes leading to pancytopenia in patients presenting to tertiary care hospital. (24353701)
2013
5
Congenital amegakaryocytic thrombocytopenia (CAMT) presenting as severe pancytopenia in the first month of life. (23625800)
2013
6
Calf-level factors associated with bovine neonatal pancytopenia - a multi-country case-control study. (24312485)
2013
7
Imported case of visceral leishmaniasis presenting as pancytopenia in a Norwegian patient treated with methotrexate and etanercept for psoriasis arthritis. (22886470)
2013
8
Hematologic Recovery of Pancytopenia after Treatment of Hashimoto's Thyroiditis and Primary Adrenal Insufficiency. (23626971)
2013
9
Parvovirus B19 presenting with persistent pancytopenia in a patient of T-ALL post induction chemotherapy diagnosed on bone marrow examination. (21934234)
2011
10
Successful use of tocilizumab in a patient with rheumatoid arthritis following severe pancytopenia during etanercept therapy. (21946465)
2011
11
Spontaneous tumor lysis syndrome with resolution of pancytopenia and disappearance of lymphadenopathy in a patient with peripheral T cell lymphoma unspecified. (21347646)
2011
12
Genes and the development of bovine neonatal pancytopenia. (21429777)
2011
13
Fulminant pancytopenia due to cytomegalovirus infection in an immunocompetent adult. (20563446)
2010
14
Amiodarone-induced bone marrow granulomas: an unusual cause of reversible pancytopenia. (22184519)
2010
15
Pancytopenia in hospitalized children: a five-year review. (20523248)
2010
16
Possible preventive strategy for bovine neonatal pancytopenia. (21257514)
2010
17
Acute severe pancytopenia associated with clopidogrel. (19367789)
2009
18
Unusual pancytopenia secondary to haemophagocytosis syndrome in rickettsioses. (19446860)
2009
19
Fatal pancytopenia in a hemodialysis patient after treatment with low-dose methotrexate. (19502905)
2009
20
A 15-year-old girl with pancytopenia and congenital defects. (19584579)
2009
21
A study of clinico-haematological profiles of pancytopenia in children. (18820199)
2008
22
Enoxaparin-induced reversible pancytopenia. (17911201)
2007
23
Apparent vaccine-thimerosal induced hypersensitivity, myelodysplastic syndrome and pancytopenia. (19734619)
2007
24
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease. (16880012)
2007
25
The incidence of pancytopenia in patients taking leflunomide alone or with methotrexate. (16634119)
2007
26
A 14-year-old girl with pancytopenia. (16493913)
2006
27
Serious pancytopenia from methotrexate treatment of psoriatic arthritis. (16635735)
2006
28
Pancytopenia in untreated patients with Graves' disease. (16646688)
2006
29
Meningoencephalitis, pancytopenia, pulmonary insufficiency and splenic abscess in a patient with brucellosis. (16598314)
2006
30
Metastatic malignant melanoma presenting as pancytopenia in a three-year-old boy. (15800910)
2005
31
Systemic lupus erythematosus presenting with pancytopenia due to bone marrow myelofibrosis in a 22-year-old male. (16163223)
2004
32
Fatal immune-mediated pancytopenia and a TRALI-like syndrome associated with high titers of recipient-type antibodies against donor-derived peripheral blood cells after allogeneic bone marrow transplantation following dose reduced conditioning. (15136241)
2004
33
A case report of pancytopenia with quetiapine use. (14609812)
2003
34
Challenges with linezolid therapy and reversible pancytopenia. (12811516)
2003
35
A young woman with fever and pancytopenia. (14506825)
2003
36
Girl with combined cellular immunodeficiency, pancytopenia, malformations, deletion 11q23.3 --> qter, and trisomy 8q24.3 --> qter. (11920839)
2002
37
Methotrexate-induced pancytopenia and death in the Japanese literature. (24383840)
2002
38
Colchicine induced toxicity and pancytopenia at usual doses and treatment with granulocyte colony-stimulating factor. (11361215)
2001
39
Pancytopenia and colitis with Clostridium difficile in a rheumatoid arthritis patient taking methotrexate, antibiotics and non-steroidal anti-inflammatory drugs. (11254248)
2001
40
Pancytopenia after treatment of keratoacanthoma by single lesional methotrexate infiltration. (11493112)
2001
41
Pyrexia and pancytopenia with unusual host immune response. (10727577)
2000
42
Lethal pancytopenia associated with chilblain lupus erythematosus. (11200851)
2000
43
Fever, rash, and pancytopenia following vancomycin rechallenge in the presence of ceftazidime. (10676837)
2000
44
Severe pancytopenia after leflunomide in rheumatoid arthritis. (10989684)
2000
45
Bilateral renal agenesis, cardiac hypertrophy and pancytopenia, a new syndrome? (9823496)
1998
46
Thymoma-associated pancytopenia: effectiveness of cyclosporine A. (9829850)
1998
47
"Emergency hepatectomy" in a 16-month-old boy with a hepatoblastoma, severe cytomegalovirus-induced pancytopenia, and intractable diarrhea. (9880755)
1998
48
The Hoyeraal-Hreidarsson syndrome: the fourth case of a separate entity with prenatal growth retardation, progressive pancytopenia and cerebellar hypoplasia. (7607282)
1995
49
Serum monocyte colony-stimulating factor, erythropoietin and interleukin-6 in relation to pancytopenia in hairy cell leukemia. (1625496)
1992
50
Inhibition of bone marrow stem cell growth in vitro by methylmalonic acid: a mechanism for pancytopenia in a patient with methylmalonic acidemia. (7254944)
1981

Variations for Pancytopenia

About this section

Expression for genes affiliated with Pancytopenia

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pancytopenia

Search GEO for disease gene expression data for Pancytopenia.

Pathways for genes affiliated with Pancytopenia

About this section
Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 52PharmGKB, 61Thomson Reuters
See all sources

Pathways related to Pancytopenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
One Carbon Metabolism39
dTMP de novo biosynthesis (mitochondrial)39
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate39
Trans-sulfuration and one carbon metabolism39
methionine salvage39
Methionine metabolism61
9.4TCN2, TPMT

Compounds for genes affiliated with Pancytopenia

About this section
Sources:
46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR
See all sources

Compounds related to Pancytopenia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1uridine46 25 1211.7DKC1, TPMT
25fluorouracil469.5TPMT, MPL
3folate469.0IKZF1, TCN2, TPMT
4aspirin46 52 30 2512.0MPL, GBA
5alanine469.0MPL, TPMT, IKZF1
6methotrexate52 46 1210.9TPMT, GBA

GO Terms for genes affiliated with Pancytopenia

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Pancytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomal lumenGO:0432029.0TCN2, GBA

Biological processes related to Pancytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to testosteroneGO:0335749.2TPMT, GBA

Products for genes affiliated with Pancytopenia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pancytopenia

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet