MCID: PNC001
MIFTS: 55

Pancytopenia malady

Summaries for Pancytopenia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood... more...

MalaCards: Pancytopenia, also known as pancytopenia nos, is related to leukemia and hepatitis. An important gene associated with Pancytopenia is TPMT (thiopurine S-methyltransferase), and among its related pathways are TGF-Beta Pathway and Rho Family GTPases. The compounds gm-csf and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Pancytopenia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

pancytopenia 8 10 44 60
pancytopenia nos 8


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Disease Ontology8 DOID:12450
MeSH34 D010198
ICD9CM27 284.1

Related Diseases for Pancytopenia

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17GeneCards, 18GeneDecks
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Diseases in the Pancytopenia family:

Pancytopenia Due to Ikzf1 Mutations

Diseases related to Pancytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 319)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.5TPMT, TCN2, THPO, IL3, IL2RA, IKZF1
2hepatitis30.5CP, HP
3arthritis30.5CSF2, CSF1, CD55, HP
4tuberculosis30.4HP, DHFR, IL2RA, CP
5rheumatoid arthritis30.4CSF2, CSF1, CD68, CD55, HP, DHFR
6dyskeratosis congenita30.4DKC1, CSF2
7acute leukemia30.3TPMT, THPO, IL3, DHFR, EPO, MPL
8malaria30.2HP, DHFR, TCN2, CP
9aplastic anemia30.2CSF2, PIGA, CD55
10hepatitis b30.2DHFR
11hypersplenism30.2THPO, GBA
12graves' disease30.2IL2RA, CD55
13myelofibrosis30.2EPO, THPO
14megaloblastic anemia30.2TCN2, HP
15fanconi's anemia30.2THPO, IL3, DHFR, DKC1
16pneumonia30.1DHFR, CSF3, CSF2
17thrombocytopenia30.1GBA, HP, EPO, MPL, PIGA, MGMT
18vasculitis30.0TPMT
19hepatitis c30.0HP, THPO
20hemophagocytic lymphohistiocytosis30.0IL2RA
21hemoglobinuria30.0PIGA, CD55, HP, TCN2
22graft versus host disease30.0CSF2, CSF3, IL2RA, IL3
23myeloid leukemia30.0CSF2, CSF3, CSF1, MPL, DHFR, IL3
24systemic lupus erythematosus30.0MPL, CD55, IL2RA, TPMT
25breast cancer30.0CSF2, CSF3, CSF1, CD55, DHFR, THPO
26deficiency anemia30.0CSF3, CSF2, PIGA, MPL, CD55, CP
27pancreatitis29.9TPMT
28iron deficiency anemia29.9EPO, THPO
29gaucher's disease29.9GBA
30leukemoid reaction29.9CSF2, CSF3, IL3
31felty's syndrome29.9CSF2, CSF3, IL3
32hyperparathyroidism29.9EPO
33primary hyperoxaluria29.9EPO, HP, THPO, TCN2
34t-cell leukemia29.9DHFR, IKZF1, IL2RA, IL3
35hemolytic anemia29.9PIGA, CD55, EPO, HP, CP
36hodgkin's lymphoma29.9CSF2, CSF3, CD68, IL2RA, IL3
37multiple myeloma29.6CSF3
38hepatocellular carcinoma29.6MGMT
39sarcoidosis29.6IL2RA
40hepatoblastoma29.6THPO, MPL
41acquired immunodeficiency syndrome29.6CSF2, DHFR
42congenital amegakaryocytic thrombocytopenia29.6THPO, IL3, MPL
43severe combined immunodeficiency29.6IL3, IL2RA, CSF1
44psoriasis29.6IL2RA, DHFR, CD55
45autoimmune hemolytic anemia29.6HP, CD55, PIGA
46polycythemia29.6MPL, EPO, IL3, THPO
47polycythemia vera29.6MPL, EPO, IL3, THPO
48capillary leak syndrome29.6CSF2
49nephrotic syndrome29.6IL2RA, HP
50eosinophilia29.6CSF2, CSF1, IL2RA, IL3

Graphical network of the top 20 diseases related to Pancytopenia:



Diseases related to pancytopenia

Clinical Features for Pancytopenia

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Drugs & Therapeutics for Pancytopenia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pancytopenia

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Anatomical Context for Pancytopenia

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32MalaCards
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MalaCards organs/tissues related to Pancytopenia:

32
Bone, Bone marrow, Kidney, T cells, Liver, Myeloid, Breast, B cells, Monocytes, Pancreas, Thyroid, Spleen, Colon, Whole blood, Lymph node, Ovary, Skin, Spinal cord, Heart, Lung

Animal Models for Pancytopenia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pancytopenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.1HP, CD55, DKC1
2MP:001077110.0PIGA, DKC1, GBA, IKZF1
3MP:00020069.9MGMT, PIGA, DKC1, HP, IKZF1
4MP:00053709.5CSF1, EPO, HP, GBA, IKZF1, CP
5MP:00053789.2CSF2, CSF1, PIGA, MPL, DKC1, CD55
6MP:00053849.2CSF2, CSF1, PIGA, MPL, DKC1, EPO
7MP:00053769.2DKC1, MPL, MGMT, CSF1, CSF2, CD55
8MP:00053878.9CD68, DKC1, MPL, CSF1, CSF3, CSF2
9MP:00107688.9DKC1, MPL, PIGA, MGMT, CSF1, CSF2
10MP:00053978.6CP, CSF2, CSF3, CSF1, PIGA, MPL

Publications for Pancytopenia

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50PubMed
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Articles related to Pancytopenia:

(show top 50)    (show all 553)
idTitleAuthorsYear
1
Copper deficiency (hypocupremia) and pancytopenia late after gastric bypass surgery. (24082414)
2013
2
A 75-year-old missionary with fever, splenomegaly and pancytopenia. (24156227)
2013
3
Fever of unknown origin and pancytopenia caused by culture-proven delayed onset disseminated bacillus Calmette-Guerin (BCG) infection after intravesical instillation. (23576657)
2013
4
An etiological reappraisal of pancytopenia - largest series reported to date from a single tertiary care teaching hospital. (24238033)
2013
5
Cobalamin and folic Acid status in relation to the etiopathogenesis of pancytopenia in adults at a tertiary care centre in north India. (22545211)
2012
6
A Jehovah's Witness adolescent with pancytopenia. (22586337)
2012
7
Case control study to investigate risk factors for bovine neonatal pancytopenia (BNP) in young calves in southern Germany. (22386740)
2012
8
Vitamin Ba88a88-responsive pancytopenia mimicking myelodysplastic syndrome. (21487214)
2011
9
Orthorexia nervosa with hyponatremia, subcutaneous emphysema, pneumomediastimum, pneumothorax, and pancytopenia. (21998605)
2011
10
Vaccine-induced antibodies linked to bovine neonatal pancytopenia (BNP) recognize cattle major histocompatibility complex class I (MHC I). (21878124)
2011
11
Neurologic dysfunction and pancytopenia secondary to acquired copper deficiency following duodenal switch: case report and review of the literature. (21947641)
2011
12
Progressive multifocal leukoencephalopathy in a 16-year-old patient with pancytopenia after autologous bone marrow transplantation for relapsed Hodgkin lymphoma. (21154950)
2011
13
Enteric fever with severe pancytopenia in a four year girl. (22049899)
2010
14
Pancytopenia due to massive bone marrow involvement in a patient with primary hyperoxaluria. (20034985)
2010
15
Successful treatment of refractory donor lymphocyte infusion-induced immune-mediated pancytopenia with rituximab. (19890900)
2010
16
Immune-mediated pancytopenia induced by oxaliplatin: a case report. (20210930)
2010
17
Pancytopenia and severe sepsis in an adult case of congenital X-linked agammaglobulinemia (XLA). (20077117)
2010
18
Acute severe pancytopenia associated with clopidogrel. (19367789)
2009
19
Autoimmune thyroiditis associated with marrow fibrosis and pancytopenia. (19860619)
2009
20
An HIV-infected patient with fever, pancytopenia, and renal failure: is this end-stage AIDS? (18472444)
2008
21
Pancytopenia and atrial fibrillation associated with chronic hepatitis C infection and presumed hepatocellular carcinoma: a case report. (18694489)
2008
22
Ataxia and pancytopenia caused by a mutation in TINF2. (18979121)
2008
23
Fever and pancytopenia in a patient with AIDS. (18922069)
2008
24
An infant with fever, hepatosplenomegaly, and pancytopenia. (18520595)
2008
25
Early-onset pancytopenia and skin ulcer following low-dose methotrexate therapy. (18829735)
2008
26
The incidence of pancytopenia in patients taking leflunomide alone or with methotrexate. (16634119)
2007
27
Meningoencephalitis, pancytopenia, pulmonary insufficiency and splenic abscess in a patient with brucellosis. (16598314)
2006
28
Copper deficiency pancytopenia with infectious complications after hemolytic anemia. (16944147)
2006
29
Pancytopenia with levofloxacin therapy for pelvic inflammatory disease in an otherwise healthy young patient. (16896021)
2006
30
Death related to albendazole-induced pancytopenia: case report and review. (15772324)
2005
31
Pancytopenia in children: etiological profile. (16014764)
2005
32
Fanconi anemia in a neonate with pancytopenia. (15238921)
2004
33
Girl with combined cellular immunodeficiency, pancytopenia, malformations, deletion 11q23.3 --> qter, and trisomy 8q24.3 --> qter. (11920839)
2002
34
Short-term complete remission of a patient with human T lymphotropic virus type-1 associated adult T-cell leukemia/lymphoma with pancytopenia by sequential high-dose methylprednisolone and cyclosporin A. (11780471)
2001
35
Mitotane-induced febrile pancytopenia: a first case report in paraneoplastic Cushing's syndrome. (11174841)
2001
36
Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning. (11757993)
2001
37
Lethal pancytopenia associated with chilblain lupus erythematosus. (11200851)
2000
38
Severe pancytopenia after leflunomide in rheumatoid arthritis. (10989684)
2000
39
Relapsing pancytopenia following exposure and re-exposure to cyanamide. (11168499)
2000
40
Pancytopenia due to the interaction of allopurinol with azathioprine or mercaptopurine. (11503788)
2000
41
Pancytopenia after removal of copper from total parenteral nutrition. (11071596)
2000
42
Familial cerebellar hypoplasia and pancytopenia without chromosomal breakages. (10029349)
1998
43
Human parvovirus B19 capsid antigen in granulocytes in parvovirus-B19-induced pancytopenia after bone marrow transplantation. (9973642)
1998
44
The Hoyeraal-Hreidarsson syndrome: the fourth case of a separate entity with prenatal growth retardation, progressive pancytopenia and cerebellar hypoplasia. (7607282)
1995
45
The significance of pancytopenia in miliary tuberculosis. (3444806)
1987
46
Tuberculous peritonitis in association with pancytopenia and pseudo-obstruction of the colon. (3612667)
1987
47
Pancytopenia--a rare complication of miliary tuberculosis. (6862864)
1983
48
Survival of a patient with pancytopenia and disseminated coagulation associated with miliary tuberculosis. (630975)
1978
49
Fanconi-like syndrome. Immunologic deficiency, pancytopenia, and cutaneous malignancies. (4692131)
1973
50
Pancytopenia as presenting syndrome in subacute bacterial endocarditis, cured by penicillin treatment. (13443881)
1957

Genetic Variations for Pancytopenia

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Expression for genes affiliated with Pancytopenia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancytopenia

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Pathways for genes affiliated with Pancytopenia

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51QIAGEN, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Pancytopenia

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Pancytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.8THPO
2estrogen4410.7THPO
3dexamethasone44 49 28 1113.4MGMT, CD55, IKZF1, IL3
4anagrelide44 1111.4CSF2, MPL, EPO, THPO
5molgramostim4410.3CSF2, CSF3, CSF1, IL3
6mafosfamide4410.3THPO, IL3, CSF3, CSF2
7pegfilgrastim44 1111.3IL3, EPO, CSF3, CSF2
8butyrate4410.3CSF2, CSF1, DHFR, THPO
9diethyl dithiocarbamate4410.2DHFR, TPMT, IL2RA, CSF1, EPO
10amifostine44 1111.2THPO, CSF2, CSF3, IL3, EPO
11pixy3214410.1THPO, IL3, CSF2, CSF3, EPO, CSF1
12leucovorin44 49 1112.1CSF3, DHFR, CSF2, IL3, THPO
13filgrastim44 1111.1CSF3, CSF2, THPO, IL3, EPO, CSF1
14mycophenolate mofetil44 49 1112.1CSF3, TPMT, IL3, IL2RA, EPO
15paclitaxel44 49 1112.1CSF1, DHFR, IL3, CSF3
16ifosfamide44 1111.1CSF1, THPO, IL3, MGMT, CSF2, CSF3
17zidovudine44 1111.0IL3, DHFR, EPO, CSF1, CSF3, CSF2
18rituximab44 49 1112.0IL2RA, HP, CD55, CSF1, CSF2, CSF3
19ribavirin44 49 1112.0IL3, EPO, CSF3, HP, CSF2
20n-formylmethionyl-leucylphenylalanine4410.0IL3, CSF2, CSF1, CD55, CSF3
21aspirin44 49 28 2413.0CSF2, THPO, IL2RA, GBA, HP, MPL
22hydroxyurea44 49 1112.0CSF1, CSF3, IL3, CSF2, THPO, EPO
23methylcellulose4410.0IL3, EPO, PIGA, CSF1, THPO, CSF2
24creatinine4410.0CP, CSF1, CD55, EPO, HP, THPO
25methotrexate44 49 1111.9CSF3, MGMT, TPMT, IL2RA, EPO, DHFR
26cytarabine44 49 1111.9CSF1, CSF3, EPO, IL3, THPO, TPMT
27ascorbic acid44 2410.9IL2RA, EPO, CP, HP, DHFR, IL3
28carboplatin44 49 1111.9CSF2, CSF3, CSF1, MGMT, EPO, HP
29polysaccharide449.9IL3, IL2RA, CSF2, THPO, CD55, GBA
30folate449.9CP, TPMT, TCN2, IL2RA, IKZF1, DHFR
31melphalan44 1110.8CSF3, MGMT, IL3, CSF2, EPO
32heparin44 28 11 2412.8THPO, HP, CSF2, CSF1, CD55, CP
33neopterin449.8CSF2, IL3, IL2RA, HP, CSF1
34etoposide44 49 59 1112.8CSF2, THPO, CSF3, IL3, DHFR, MGMT
35gp 130449.8THPO, IL3, EPO, MPL, CSF1, CSF3
36lactate449.8CSF2, CSF1, MGMT, CP, EPO, IL3
37cyclosporin a44 28 5911.8IL3, TPMT, IL2RA, HP, EPO, CD55
38histamine44 28 2411.7IL3, THPO, TPMT, IL2RA, CSF1, CSF2
39cyclophosphamide44 49 1111.7IL3, MGMT, CSF1, IL2RA, PIGA, CSF3
40thymidine44 2410.7IL3, CSF3, THPO, CSF2, IL2RA, GBA
41alanine449.7CD55, HP, DHFR, MPL, CSF1, IKZF1
425fluorouracil449.7DHFR, CSF3, CSF1, MGMT, MPL, CSF2
43adenylate449.7IL2RA, THPO, CP, DHFR, HP, CSF1
44cisplatin44 49 59 1112.6EPO, CSF1, CSF3, MGMT, CSF2, TPMT
45fmlp449.6CSF2, THPO, IL3, CD55, CSF1, CSF3
46neomycin449.6EPO, CSF1, GBA, DHFR, IL3
47doxorubicin44 49 1111.5IL3, IL2RA, DHFR, CSF3, MGMT, CSF1
48phosphatidylinositol449.5IL3, EPO, THPO, CD55, MPL, PIGA
49vegf449.5CD55, MPL, MGMT, CSF1, CSF3, CSF2
50cysteine449.4MGMT, MPL, THPO, IL3, CSF1, CSF2

GO Terms for genes affiliated with Pancytopenia

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16Gene Ontology
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Cellular components related to Pancytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.6CD55, EPO, HP, IL3, TCN2, CP
2extracellular spaceGO:0056159.1CP, CSF2, CSF3, CSF1, EPO, HP

Biological processes related to Pancytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of Ras protein signal transductionGO:04657910.2EPO, CSF1
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.2IL3, EPO, CSF2
3positive regulation of DNA replicationGO:04574010.1IL3, EPO, CSF2
4positive regulation of macrophage derived foam cell differentiationGO:0107449.9CSF1, CSF2
5cell proliferationGO:0082839.9CSF1, MPL, DKC1, IL2RA, THPO
6positive regulation of cell proliferationGO:0082849.7CSF2, CSF3, CSF1, EPO, IL3

Molecular functions related to Pancytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.8CSF3, CSF1, IL3, THPO, CSF2
2growth factor activityGO:0080839.5THPO, IL3, CSF1, CSF3, CSF2

Products for genes affiliated with Pancytopenia

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Sources for Pancytopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet