MCID: PNC001
MIFTS: 55

Pancytopenia malady

Summaries for Pancytopenia

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood... more...

MalaCards: Pancytopenia, also known as pancytopenia nos, is related to leukemia and hepatitis. An important gene associated with Pancytopenia is TPMT (thiopurine S-methyltransferase), and among its related pathways are TGF-Beta Pathway and Rho Family GTPases. The compounds gm-csf and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Pancytopenia

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 27ICD9CM
See all sources

Aliases & Descriptions:

pancytopenia 8 10 44 60
pancytopenia nos 8


External Ids:

Disease Ontology8 DOID:12450
MeSH34 D010198
ICD9CM27 284.1

Related Diseases for Pancytopenia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pancytopenia family:

Pancytopenia Due to Ikzf1 Mutations

Diseases related to Pancytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 319)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.5TPMT, TCN2, THPO, IL3, IL2RA, IKZF1
2hepatitis30.5CP, HP
3arthritis30.5CSF2, CSF1, CD55, HP
4tuberculosis30.4HP, DHFR, IL2RA, CP
5rheumatoid arthritis30.4CSF2, CSF1, CD68, CD55, HP, DHFR
6dyskeratosis congenita30.4DKC1, CSF2
7acute leukemia30.3TPMT, THPO, IL3, DHFR, EPO, MPL
8malaria30.2HP, DHFR, TCN2, CP
9aplastic anemia30.2CSF2, PIGA, CD55
10hepatitis b30.2DHFR
11hypersplenism30.2THPO, GBA
12graves' disease30.2IL2RA, CD55
13myelofibrosis30.2EPO, THPO
14megaloblastic anemia30.2TCN2, HP
15fanconi's anemia30.2THPO, IL3, DHFR, DKC1
16pneumonia30.1DHFR, CSF3, CSF2
17thrombocytopenia30.1GBA, HP, EPO, MPL, PIGA, MGMT
18vasculitis30.0TPMT
19hepatitis c30.0HP, THPO
20hemophagocytic lymphohistiocytosis30.0IL2RA
21hemoglobinuria30.0PIGA, CD55, HP, TCN2
22graft versus host disease30.0CSF2, CSF3, IL2RA, IL3
23myeloid leukemia30.0CSF2, CSF3, CSF1, MPL, DHFR, IL3
24systemic lupus erythematosus30.0MPL, CD55, IL2RA, TPMT
25breast cancer30.0CSF2, CSF3, CSF1, CD55, DHFR, THPO
26deficiency anemia30.0CSF3, CSF2, PIGA, MPL, CD55, CP
27pancreatitis29.9TPMT
28iron deficiency anemia29.9EPO, THPO
29gaucher's disease29.9GBA
30leukemoid reaction29.9CSF2, CSF3, IL3
31felty's syndrome29.9CSF2, CSF3, IL3
32hyperparathyroidism29.9EPO
33primary hyperoxaluria29.9EPO, HP, THPO, TCN2
34t-cell leukemia29.9DHFR, IKZF1, IL2RA, IL3
35hemolytic anemia29.9PIGA, CD55, EPO, HP, CP
36hodgkin's lymphoma29.9CSF2, CSF3, CD68, IL2RA, IL3
37multiple myeloma29.6CSF3
38hepatocellular carcinoma29.6MGMT
39sarcoidosis29.6IL2RA
40hepatoblastoma29.6THPO, MPL
41acquired immunodeficiency syndrome29.6CSF2, DHFR
42congenital amegakaryocytic thrombocytopenia29.6THPO, IL3, MPL
43severe combined immunodeficiency29.6IL3, IL2RA, CSF1
44psoriasis29.6IL2RA, DHFR, CD55
45autoimmune hemolytic anemia29.6HP, CD55, PIGA
46polycythemia29.6MPL, EPO, IL3, THPO
47polycythemia vera29.6MPL, EPO, IL3, THPO
48capillary leak syndrome29.6CSF2
49nephrotic syndrome29.6IL2RA, HP
50eosinophilia29.6CSF2, CSF1, IL2RA, IL3

Graphical network of the top 20 diseases related to Pancytopenia:



Diseases related to pancytopenia

Clinical Features for Pancytopenia

About this section

Drugs & Therapeutics for Pancytopenia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pancytopenia

Drug clinical trials:

Search ClinicalTrials for Pancytopenia

Search NIH Clinical Center for Pancytopenia

Search CenterWatch for Pancytopenia

Genetic Tests for Pancytopenia

About this section

Anatomical Context for Pancytopenia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Pancytopenia:

32
Bone, Bone marrow, Kidney, T cells, Liver, Breast, Myeloid, B cells, Spleen, Monocytes, Pancreas, Thyroid, Colon, Heart, Whole blood, Lung, Lymph node, Spinal cord, Ovary, Skin

Animal Models for Pancytopenia or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Pancytopenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.1HP, CD55, DKC1
2MP:001077110.0GBA, DKC1, PIGA, IKZF1
3MP:00020069.9HP, MGMT, PIGA, DKC1, IKZF1
4MP:00053709.5CSF1, EPO, HP, GBA, IKZF1, CP
5MP:00053789.2IL2RA, TPMT, GBA, CD55, DKC1, MPL
6MP:00053849.2CP, CSF2, IL3, IL2RA, IKZF1, GBA
7MP:00053769.2IL3, GBA, HP, EPO, CD55, DKC1
8MP:00053878.9CSF1, IKZF1, DKC1, CSF2, MPL, CP
9MP:00107688.9IL2RA, DKC1, IL3, IKZF1, GBA, HP
10MP:00053978.6MPL, IL3, CD68, HP, GBA, IKZF1

Publications for Pancytopenia

About this section
Sources:
50PubMed
See all sources

Articles related to Pancytopenia:

(show top 50)    (show all 553)
idTitleAuthorsYear
1
The common causes leading to pancytopenia in patients presenting to tertiary care hospital. (24353701)
2013
2
The differential diagnosis and bone marrow evaluation of new-onset pancytopenia. (23270895)
2013
3
A rare case of suprahepatic gall bladder with phocomelia and pancytopenia: detected by tc-99m mebrofenin scintigraphy. (23961256)
2013
4
Utility of maternal 6-thioguanine nucleotide levels in predicting neonatal pancytopenia. (23943705)
2013
5
Role of splenic artery partial embolization in a patient with portal hypertension and pancytopenia undergoing hysterectomy under anesthesia. (22586877)
2012
6
Pancytopenia with cellular bone marrow related to Graves' hyperthyroidism. (22629533)
2012
7
Bovine neonatal pancytopenia in calves in Poland. (23214380)
2012
8
Pancytopenia and myeloid maturation arrest in an autologous stem cell transplant recipient. (20622905)
2011
9
Bovine neonatal pancytopenia-like syndrome in dromedaries. (21856672)
2011
10
Fulminant pancytopenia due to cytomegalovirus infection in an immunocompetent adult. (20563446)
2010
11
Pancytopenia in hospitalized children: a five-year review. (20523248)
2010
12
Pancytopenia secondary to hypopituitarism may just be due to hypothyroidism alone. (20309687)
2010
13
Idiopathic bovine neonatal pancytopenia in a Scottish beef herd. (21262695)
2010
14
Pancytopenia in a patient with Lyme disease. (20358248)
2010
15
Congenital lupus erythematosus presenting at birth with widespread erosions, pancytopenia, and subsequent hepatobiliary disease. (20199433)
2010
16
Gene therapy of MPL deficiency: challenging balance between leukemia and pancytopenia. (19844195)
2010
17
Pancytopenia in a 4-year-old boy. 22q11.2 microdeletion syndrome. (19389118)
2009
18
Cardiac left bundle branch block and pancytopenia in anorexia nervosa: higher risk with mirtazapine and pantoprazole? Case report. (19308886)
2009
19
A study of clinico-haematological profiles of pancytopenia in children. (18820199)
2008
20
A neonate with petechiae and pancytopenia at birth as uncommon presentation of congenital HIV infection. (19253514)
2008
21
Recurrent episodes of fever and pancytopenia due to haemophagocytosis during maintenance therapy for acute myeloid leukaemia. (18710392)
2008
22
What is your diagnosis? Pancytopenia in a dog. (19055579)
2008
23
Severe pancytopenia associated with a minor paroxysmal nocturnal haemoglobinuria clone and response to ciclosporin A in a heavily pretreated multiple myeloma patient. (18279453)
2008
24
The first documented case of brucellosis manifested with pancytopenia and capillary leak syndrome. (18451581)
2008
25
Low-dose methotrexate-induced pancytopenia. (16636937)
2007
26
An atypical form of Asian variant of intravascular large B-cell lymphoma presenting with myelopathy alone for 4 months prior to pancytopenia. (18025772)
2007
27
A case of pancytopenia. (16714327)
2006
28
A case of delirium and subsequent pancytopenia associated with the oral loading of valproic acid. (15960580)
2005
29
Captopril-induced pancytopenia in a premature newborn. (15228574)
2004
30
Pancytopenia responding to treatment of hyperthyroidism: a clinical case and review of the literature. (12452820)
2002
31
Transient pancytopenia associated with parvovirus infection in a healthy child. (12421275)
2002
32
Thymoma and pancytopenia: a very rare association. (12091142)
2002
33
Colchicine induced toxicity and pancytopenia at usual doses and treatment with granulocyte colony-stimulating factor. (11361215)
2001
34
A 41-year-old, HIV-infected man with fever, pulmonary nodules, and pancytopenia. (11269795)
2001
35
Severe pancytopenia and intrahepatic cholestasis in a patient with a history of Hodgkin's disease. Responsiveness to high-dose pulse steroid therapy and diagnosis of a late relapse. (11711275)
2001
36
A case of thyrotoxicosis with pancytopenia. (11523911)
2001
37
Pancytopenia--a six year study. (11868860)
2001
38
Successful marrow transplantation for correction of immunological deficit in lymphopenic agammaglobulinemia and treatment of immunologically induced pancytopenia. Reprinted from Experimental Hematology 1969; 11:-10. (11276352)
2001
39
Successful non-surgical treatment of disseminated polymicrobial fungal infection in a patient with pancytopenia and graft-versus-host disease. (11120619)
2000
40
Drug-induced pancytopenia in a patient with juvenile HLA-B27-associated spondylarthritis: comment on the article by Leipold et al. (9778238)
1998
41
A single dose of thrombopoietin shortly after myelosuppressive total body irradiation prevents pancytopenia in mice by promoting short-term multilineage spleen-repopulating cells at the transient expense of bone marrow-repopulating cells. (9716586)
1998
42
Acetazolamide-induced severe pancytopenia mimicking myelodysplasia relapse following allogeneic bone marrow transplantation. (9489658)
1998
43
Parvovirus-induced pancytopenia in a child with acquired haemolytic anaemia. (9460570)
1997
44
Severe pancytopenia in old age after 12-month ACE inhibitor therapy]. (7519541)
1994
45
Evaluation of granulocyte-macrophage colony-stimulating factor for treatment of pancytopenia in children with fanconi anemia. (8283365)
1994
46
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 4-1992. Pancytopenia, splenomegaly, and retinal hemorrhage in a 52-year-old diabetic man. (1727979)
1992
47
Simultaneous primary infection with HIV and CMV leading to severe pancytopenia, hepatitis, nephritis, perimyocarditis, myositis, and alopecia totalis. (2156107)
1990
48
Megaloblastic anemia and pancytopenia due to Proguanil in patients with chronic renal failure. (7140018)
1982
49
Inhibition of bone marrow stem cell growth in vitro by methylmalonic acid: a mechanism for pancytopenia in a patient with methylmalonic acidemia. (7254944)
1981
50
The pancytopenia of isovaleric acidemia. (7367115)
1980

Genetic Variations for Pancytopenia

About this section

Expression for genes affiliated with Pancytopenia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pancytopenia

Search GEO for disease gene expression data for Pancytopenia.

Pathways for genes affiliated with Pancytopenia

About this section
Sources:
51QIAGEN, 37NCBI BioSystems Database, 29KEGG
See all sources

Compounds for genes affiliated with Pancytopenia

About this section
Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
See all sources

Compounds related to Pancytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.8THPO
2estrogen4410.7THPO
3dexamethasone44 49 28 1113.4MGMT, CD55, IKZF1, IL3
4anagrelide44 1111.4CSF2, MPL, EPO, THPO
5molgramostim4410.3CSF2, CSF3, CSF1, IL3
6mafosfamide4410.3THPO, IL3, CSF3, CSF2
7pegfilgrastim44 1111.3IL3, EPO, CSF3, CSF2
8butyrate4410.3CSF2, CSF1, DHFR, THPO
9diethyl dithiocarbamate4410.2DHFR, TPMT, IL2RA, CSF1, EPO
10amifostine44 1111.2THPO, CSF2, CSF3, IL3, EPO
11pixy3214410.1THPO, IL3, CSF2, CSF3, EPO, CSF1
12leucovorin44 49 1112.1CSF3, DHFR, CSF2, IL3, THPO
13filgrastim44 1111.1CSF3, CSF2, THPO, IL3, EPO, CSF1
14mycophenolate mofetil44 49 1112.1CSF3, TPMT, IL3, IL2RA, EPO
15paclitaxel44 49 1112.1CSF1, DHFR, IL3, CSF3
16ifosfamide44 1111.1CSF1, THPO, IL3, MGMT, CSF2, CSF3
17zidovudine44 1111.0IL3, DHFR, EPO, CSF1, CSF3, CSF2
18rituximab44 49 1112.0IL2RA, HP, CD55, CSF1, CSF2, CSF3
19ribavirin44 49 1112.0IL3, EPO, CSF3, HP, CSF2
20n-formylmethionyl-leucylphenylalanine4410.0IL3, CSF2, CSF1, CD55, CSF3
21aspirin44 49 28 2413.0CSF2, THPO, IL2RA, GBA, HP, MPL
22hydroxyurea44 49 1112.0CSF1, CSF3, IL3, CSF2, THPO, EPO
23methylcellulose4410.0IL3, EPO, PIGA, CSF1, THPO, CSF2
24creatinine4410.0CP, CSF1, CD55, EPO, HP, THPO
25methotrexate44 49 1111.9CSF3, MGMT, TPMT, IL2RA, EPO, DHFR
26cytarabine44 49 1111.9CSF1, CSF3, EPO, IL3, THPO, TPMT
27ascorbic acid44 2410.9IL2RA, EPO, CP, HP, DHFR, IL3
28carboplatin44 49 1111.9CSF2, CSF3, CSF1, MGMT, EPO, HP
29polysaccharide449.9IL3, IL2RA, CSF2, THPO, CD55, GBA
30folate449.9CP, TPMT, TCN2, IL2RA, IKZF1, DHFR
31melphalan44 1110.8CSF3, MGMT, IL3, CSF2, EPO
32heparin44 28 11 2412.8THPO, HP, CSF2, CSF1, CD55, CP
33neopterin449.8CSF2, IL3, IL2RA, HP, CSF1
34etoposide44 49 59 1112.8CSF2, THPO, CSF3, IL3, DHFR, MGMT
35gp 130449.8THPO, IL3, EPO, MPL, CSF1, CSF3
36lactate449.8CSF2, CSF1, MGMT, CP, EPO, IL3
37cyclosporin a44 28 5911.8IL3, TPMT, IL2RA, HP, EPO, CD55
38histamine44 28 2411.7IL3, THPO, TPMT, IL2RA, CSF1, CSF2
39cyclophosphamide44 49 1111.7IL3, MGMT, CSF1, IL2RA, PIGA, CSF3
40thymidine44 2410.7IL3, CSF3, THPO, CSF2, IL2RA, GBA
41alanine449.7CD55, HP, DHFR, MPL, CSF1, IKZF1
425fluorouracil449.7DHFR, CSF3, CSF1, MGMT, MPL, CSF2
43adenylate449.7IL2RA, THPO, CP, DHFR, HP, CSF1
44cisplatin44 49 59 1112.6EPO, CSF1, CSF3, MGMT, CSF2, TPMT
45fmlp449.6CSF2, THPO, IL3, CD55, CSF1, CSF3
46neomycin449.6EPO, CSF1, GBA, DHFR, IL3
47doxorubicin44 49 1111.5IL3, IL2RA, DHFR, CSF3, MGMT, CSF1
48phosphatidylinositol449.5IL3, EPO, THPO, CD55, MPL, PIGA
49vegf449.5CD55, MPL, MGMT, CSF1, CSF3, CSF2
50cysteine449.4MGMT, MPL, THPO, IL3, CSF1, CSF2

GO Terms for genes affiliated with Pancytopenia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pancytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.6CSF2, CD55, EPO, HP, IL3, TCN2
2extracellular spaceGO:0056159.1CSF2, CSF3, CSF1, EPO, HP, IL3

Biological processes related to Pancytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage derived foam cell differentiationGO:01074410.2CSF2, CSF1
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.2CSF2, EPO, IL3
3positive regulation of DNA replicationGO:04574010.1EPO, IL3, CSF2
4cell proliferationGO:0082839.9THPO, CSF1, IL2RA, DKC1, MPL
5positive regulation of Ras protein signal transductionGO:0465799.9EPO, CSF1
6positive regulation of cell proliferationGO:0082849.7CSF1, IL3, CSF2, EPO, CSF3

Molecular functions related to Pancytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.8CSF2, CSF3, CSF1, IL3, THPO
2growth factor activityGO:0080839.5CSF2, CSF3, CSF1, IL3, THPO

Products for genes affiliated with Pancytopenia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pancytopenia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet