MCID: PNC001
MIFTS: 52

Pancytopenia malady

Categories: Blood diseases, Rare diseases, Immune diseases

Aliases & Classifications for Pancytopenia

Aliases & Descriptions for Pancytopenia:

Name: Pancytopenia 12 29 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12450
ICD10 33 D61.81
ICD9CM 35 284.1
MeSH 42 D010198
UMLS 69 C0030312

Summaries for Pancytopenia

MalaCards based summary : Pancytopenia is related to thrombocytopenia, congenital amegakaryocytic and hemophagocytic lymphohistiocytosis. An important gene associated with Pancytopenia is SAMD9L (Sterile Alpha Motif Domain Containing 9 Like), and among its related pathways/superpathways are Chks in Checkpoint Regulation and Jak-STAT signaling pathway (KEGG). The drugs Benzocaine and Cyclosporine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and liver, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and hematopoietic system

Wikipedia : 71 Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood... more...

Related Diseases for Pancytopenia

Diseases in the Pancytopenia family:

Pancytopenia Due to Ikzf1 Mutations

Diseases related to Pancytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
id Related Disease Score Top Affiliating Genes
1 thrombocytopenia, congenital amegakaryocytic 30.9 MPL THPO
2 hemophagocytic lymphohistiocytosis 30.9 CSF2 CSF3 IKZF1 MPL THPO
3 neuromyelitis optica 28.8 EPO MPL THPO
4 pancytopenia due to ikzf1 mutations 11.8
5 fanconi anemia, complementation group a 11.6
6 myelocerebellar disorder 11.4
7 dyskeratosis congenita 11.3
8 aplastic anemia 11.1
9 fanconi anemia, complementation group c 10.9
10 fanconi anemia, complementation group d2 10.9
11 fanconi anemia, complementation group b 10.9
12 dyskeratosis congenita, x-linked 10.9
13 sackey sakati aur syndrome 10.9
14 evans' syndrome 10.7
15 bone marrow failure syndrome 2 10.7
16 lymphoproliferative syndrome 1 10.6
17 radioulnar synostosis with amegakaryocytic thrombocytopenia 2 10.6
18 cerebroretinal microangiopathy with calcifications and cysts 2 10.6
19 osteopetrosis, autosomal recessive 5 10.6
20 osteopetrosis, autosomal recessive 4 10.6
21 virus associated hemophagocytic syndrome 10.6
22 osteopetrosis, autosomal dominant 2 10.6
23 osteopetrosis, autosomal recessive 3, with renal tubular acidosis 10.6
24 dyskeratosis congenita, autosomal recessive 3 10.6
25 osteopetrosis 10.6
26 osteopetrosis, autosomal recessive 6 10.6
27 methylmalonyl-coa epimerase deficiency 10.6
28 hemophagocytic lymphohistiocytosis, familial, 2 10.6
29 osteopetrosis, autosomal recessive 7 10.6
30 transaldolase deficiency 10.6
31 transcobalamin ii deficiency 10.6
32 osteopetrosis, autosomal dominant 1 10.6
33 lymphoproliferative syndrome, x-linked, 1 10.6
34 osteopetrosis, autosomal recessive 1 10.6
35 lymphoproliferative syndrome, x-linked, 2 10.6
36 osteopetrosis, autosomal recessive 2 10.6
37 megaloblastic anemia due to dihydrofolate reductase deficiency 10.6
38 lig4 syndrome 10.6
39 bone marrow failure syndrome 3 10.6
40 eosinophilic cystitis 10.2 CSF2 CSF3
41 febrile seizures, familial, 2 10.2 CSF2 CSF3
42 mental retardation, autosomal dominant 37 10.2 CSF2 CSF3
43 scleroderma, familial progressive 10.2 CSF2 CSF3
44 dic in newborn 10.2 CSF2 CSF3 EPO
45 acute panmyelosis with myelofibrosis 10.1 CSF2 EPO
46 adult acute lymphocytic leukemia 10.1 CSF2 CSF3 TPMT
47 cytokine receptor deficiency 10.1 CSF2 THPO
48 aniseikonia 10.1 CSF2 CSF3
49 poems syndrome 10.1 EPO THPO
50 leukemia 10.0

Graphical network of the top 20 diseases related to Pancytopenia:



Diseases related to Pancytopenia

Symptoms & Phenotypes for Pancytopenia

GenomeRNAi Phenotypes related to Pancytopenia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 DHFR FANCA FANCC FANCG MGMT

MGI Mouse Phenotypes related to Pancytopenia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 FANCC IKZF1 MPL SAMD9L TERT THPO
2 cellular MP:0005384 10.18 CSF1 CSF2 DKC1 EPO FANCA FANCC
3 homeostasis/metabolism MP:0005376 10.14 CSF1 CSF2 DKC1 EPO FANCA MGMT
4 immune system MP:0005387 10.11 CSF1 CSF2 CSF3 DKC1 EPO FANCC
5 endocrine/exocrine gland MP:0005379 10.06 CSF2 FANCA FANCC FANCG IKZF1 MGMT
6 mortality/aging MP:0010768 10.03 EPO FANCA IKZF1 MGMT MPL SAMD9L
7 integument MP:0010771 9.87 CSF1 CSF2 CSF3 DKC1 EPO IKZF1
8 neoplasm MP:0002006 9.7 CSF2 DKC1 FANCA IKZF1 MGMT SAMD9L
9 reproductive system MP:0005389 9.56 CSF1 CSF2 DKC1 FANCA FANCC FANCG
10 respiratory system MP:0005388 9.17 CSF1 CSF2 DKC1 EPO IKZF1 MGMT

Drugs & Therapeutics for Pancytopenia

Drugs for Pancytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 166)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
2
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
3
Lenograstim Approved Phase 4,Phase 2,Phase 3 135968-09-1
4
Prednisone Approved, Vet_approved Phase 4,Phase 1,Phase 2 53-03-2 5865
5
Oprelvekin Approved, Investigational Phase 4 145941-26-0
6
Etanercept Approved, Investigational Phase 4 185243-69-0
7 tannic acid Approved, Nutraceutical Phase 4
8 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
9 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
10 Analgesics Phase 4
11 Analgesics, Non-Narcotic Phase 4
12 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 1
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4
14 Gastrointestinal Agents Phase 4,Phase 2,Phase 1
15 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
16
alemtuzumab Approved, Investigational Phase 2, Phase 3,Phase 1 216503-57-0
17
Busulfan Approved, Investigational Phase 2, Phase 3, Phase 1, Early Phase 1 55-98-1 2478
18
Cyclophosphamide Approved, Investigational Phase 2, Phase 3, Phase 1, Early Phase 1 50-18-0, 6055-19-2 2907
19
Fludarabine Approved Phase 2, Phase 3, Phase 1, Early Phase 1 21679-14-1, 75607-67-9 30751
20
Vidarabine Approved Phase 2, Phase 3, Phase 1, Early Phase 1 24356-66-9 32326 21704
21
Darbepoetin alfa Approved, Investigational Phase 2, Phase 3 11096-26-7, 209810-58-2
22
Ephedrine Approved Phase 3 299-42-3 9294
23
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
24
Pseudoephedrine Approved Phase 3 90-82-4 7028
25
Nandrolone Approved, Experimental, Illicit Phase 3,Phase 1,Phase 2 434-22-0, 62-90-8 9904 229455
26
Nandrolone decanoate Approved, Illicit Phase 3,Phase 1,Phase 2 360-70-3 9677
27 Alkylating Agents Phase 2, Phase 3, Phase 1, Early Phase 1
28 Anti-Infective Agents Phase 2, Phase 3, Phase 1, Early Phase 1
29 Antimetabolites Phase 2, Phase 3, Phase 1, Early Phase 1
30 Antimetabolites, Antineoplastic Phase 2, Phase 3, Phase 1, Early Phase 1
31 Antineoplastic Agents, Alkylating Phase 2, Phase 3, Phase 1, Early Phase 1
32 Antiviral Agents Phase 2, Phase 3, Phase 1, Early Phase 1
33 Adjuvants, Immunologic Phase 2, Phase 3
34 Epoetin alfa Phase 2, Phase 3 113427-24-0
35 Hematinics Phase 2, Phase 3
36 Pharmaceutical Solutions Phase 2, Phase 3, Phase 1
37 Antilymphocyte Serum Phase 3,Phase 2,Phase 1
38 Antifungal Agents Phase 3,Phase 2,Phase 1
39 Autonomic Agents Phase 3,Phase 2,Phase 1
40 Calcineurin Inhibitors Phase 3,Phase 2,Phase 1
41 Dermatologic Agents Phase 3,Phase 2,Phase 1
42 Nasal Decongestants Phase 3
43 Ophthalmic Solutions Phase 3
44 Respiratory System Agents Phase 3
45 Tetrahydrozoline Phase 3
46 Vasoconstrictor Agents Phase 3
47 Anabolic Agents Phase 3,Phase 1,Phase 2
48 Androgens Phase 3,Phase 1,Phase 2
49 Hormone Antagonists Phase 3,Phase 2,Phase 1
50 Hormones Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 134)
id Name Status NCT ID Phase
1 Different Doses of Anti-thymocyte Globin to Treat Child Severe Aplastic Anemia Unknown status NCT01997372 Phase 4
2 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4
3 Study Evaluating the Efficacy of Enbrel (Etanercept) in Subjects in Japan Completed NCT00503503 Phase 4
4 Risk-Adapted Allogeneic Stem Cell Transplantation For Mixed Donor Chimerism In Patients With Non-Malignant Diseases Unknown status NCT01019876 Phase 2, Phase 3
5 Erythropoietin (EPO) and Granulocyte-Colony Stimulating Factor (G-CSF) for Low-Risk Myelodysplastic Syndromes (MDS) Unknown status NCT00234143 Phase 2, Phase 3
6 Comparison of Cy-Atg vs Flu-Atg for the Conditioning Therapy in Allo-HCT for Adult Aplastic Anemia Unknown status NCT01145976 Phase 3
7 Stem Cell Transplant for Bone Marrow Failure Syndromes Completed NCT00176878 Phase 2, Phase 3
8 Comparison of Cy-Atg Vs Cy-Flu-Atg for the Conditioning Therapy in Allo-HCT Completed NCT00774527 Phase 3
9 Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder Completed NCT00755040 Phase 3
10 Multi-Center Trial of Anti-Thymocyte Globulin in Treatment of Aplastic Anemia and Other Hematologic Disorders Completed NCT00000597 Phase 3
11 Eculizumab to Treat Paroxysmal Nocturnal Hemoglobinuria Completed NCT00098280 Phase 3
12 The Impact of Red Cell Age on Product Utilization in the Chronically Transfused Outpatient Population Enrolling by invitation NCT02393508 Phase 3
13 A Study Evaluating Epoetin Alfa 40,000 IU (International Units) Every Week or 80,000 IU Every Week Compared to Placebo in Patients With Low or Intermediate-1 Risk Myelodysplastic Syndromes at Risk for Transfusion Terminated NCT00695396 Phase 3
14 Eltrombopag for Enhancing Platelet Engraftment in Adult Patients Undergoing Cord Blood Transplantation Unknown status NCT01757145 Phase 2
15 Rabbit Antithymocyte Globulin Versus Campath-1H for Treating Severe Aplastic Anemia Completed NCT00065260 Phase 2
16 Donor Stem Cell Transplant After Busulfan, Fludarabine, Methylprednisolone, and Antithymocyte Globulin in Treating Patients With Bone Marrow Failure Syndrome Completed NCT00731328 Phase 2
17 Allogeneic Mixed Chimerism Stem Cell Transplant Using Campath for Hemoglobinopathies & Bone Marrow Failure Syndromes Completed NCT00004143 Phase 2
18 Three Immunosuppressive Treatment Regimens for Severe Aplastic Anemia Completed NCT00260689 Phase 2
19 Phase II Pilot Study of Granulocyte Colony-Stimulating Factor for Inherited Bone Marrow Failure Syndromes Completed NCT00004787 Phase 2
20 Reduced Intensity Conditioning Using CD3+/CD19+ Depletion for Non Malignant Transplantable Diseases Completed NCT02277639 Phase 2
21 Improving Immunosuppressive Treatment for Patients With Severe Aplastic Anemia Completed NCT00061360 Phase 2
22 Bone Marrow Transplant Plus Cyclophosphamide and Total-Body Irradiation in Treating Patients With Hematologic Cancer Completed NCT00002809 Phase 2
23 Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Other Hematologic or Metabolic Diseases Completed NCT00003662 Phase 2
24 Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia Completed NCT01193283 Phase 1, Phase 2
25 A Pilot Study of Fludarabine Plus Cyclophosphamide in Refractory Severe Aplastic Anemia Completed NCT01187017 Phase 1, Phase 2
26 Mobilization and Collection of Peripheral Blood Stem Cells in Patients With Fanconi Anemia Using G-CSF and AMD3100 Completed NCT00479115 Phase 1, Phase 2
27 Study of the Efficacy and Safety of Lenalidomide in Combination With Cyclosporine A in Patients With Myelodysplastic Syndromes Completed NCT00840827 Phase 2
28 Mobilization of Stem Cells With G-CSF for Collection From Patients With Diamond-Blackfan Anemia Completed NCT00011505 Phase 2
29 Combination Therapy of Severe Aplastic Anemia Completed NCT00001964 Phase 2
30 Idarubicin, Cytarabine, and Gemtuzumab Ozogamicin in Treating Patients With Previously Untreated High-Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia Secondary to Myelodysplastic Syndrome Completed NCT00077116 Phase 2
31 Memory T-cell Infusion to Improve Immunity After TCR-alpha/Beta Depleted Hematopoietic Stem Cell Transplantation Completed NCT02337595 Phase 1, Phase 2
32 Mycophenolate Mofetil and Cyclosporine to Treat Relapsing Aplastic Anemia Completed NCT00005935 Phase 2
33 Rituximab to Treat Moderate Aplastic Anemia, Pure Red Cell Aplasia, or Diamond Blackfan Anemia Completed NCT00229619 Phase 2
34 Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells Recruiting NCT01174108 Phase 2
35 Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia Recruiting NCT02224872 Phase 2
36 Limiting Chemotherapy Side Effects by Using Moxa Recruiting NCT02781155 Phase 1, Phase 2
37 Nandrolone Decanoate in the Treatment of Telomeropathies Recruiting NCT02055456 Phase 1, Phase 2
38 Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Congenita Recruiting NCT01659606 Phase 2
39 Haploidentical Bone Marrow Transplant With Post-Transplant Cyclophosphamide for Patients With Severe Aplastic Anemia Recruiting NCT02828592 Phase 2
40 A Single-Arm Phase 2 Study With Optimized Standard Protocol for Severe Aplastic Anemia Recruiting NCT02203396 Phase 2
41 NMA Haplo or MUD BMT for Newly Diagnosed Severe Aplastic Anemia Recruiting NCT02833805 Phase 2
42 Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders Recruiting NCT00919503 Phase 2
43 Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia Recruiting NCT01623167 Phase 1, Phase 2
44 Treosulfan-based Versus Busulfan-based Conditioning in Paediatric Patients With Non-malignant Diseases Recruiting NCT02349906 Phase 2
45 Clinical Phase II Trial to Evaluate CD34+ Cells Mobilization and Collection in Patients With Fanconi Anemia for Subsequent Transduction With a Lentiviral Vector Carring FANCA Gene. FANCOSTEM-1 Recruiting NCT02931071 Phase 2
46 Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT Recruiting NCT01962415 Phase 2
47 Donor Umbilical Cord Blood Transplant With or Without Ex-vivo Expanded Cord Blood Progenitor Cells in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, or Myelodysplastic Syndromes Recruiting NCT01690520 Phase 2
48 Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine Phosphate, and Total-Body Irradiation in Treating Patients With Hematologic Disease Recruiting NCT00719888 Phase 2
49 Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders Recruiting NCT03128996 Phase 1, Phase 2
50 CD34+Selection for Partially Matched Family or Matched Unrelated Adult Donor Transplant Recruiting NCT01049854 Phase 2

Search NIH Clinical Center for Pancytopenia

Cochrane evidence based reviews: pancytopenia

Genetic Tests for Pancytopenia

Genetic tests related to Pancytopenia:

id Genetic test Affiliating Genes
1 Pancytopenia 29

Anatomical Context for Pancytopenia

MalaCards organs/tissues related to Pancytopenia:

39
Bone, Bone Marrow, Liver, Kidney, T Cells, Myeloid, Breast

Publications for Pancytopenia

Articles related to Pancytopenia:

(show top 50) (show all 670)
id Title Authors Year
1
The risks of using allogeneic cell lines for vaccine production: the example of Bovine Neonatal Pancytopenia. ( 27744721 )
2017
2
Suspected immune-mediated neutropenia and corticosteroid responsive pancytopenia in a Portuguese water dog. ( 28042161 )
2017
3
Successful haploidentical BMT with post-transplant cyclophosphamide for refractory autoimmune pancytopenia after cord blood transplant in pediatric myelodysplastic syndrome. ( 28067878 )
2017
4
An Unusual Case of Acute Promyelocytic Leukemia Presenting With Hypoplastic Bone Marrow and Pancytopenia. ( 26992265 )
2016
5
Profile of HIV-Infected Hispanics with Pancytopenia. ( 26703689 )
2016
6
Idiopathic Fatal Pancytopenia: A Case Report. ( 27504300 )
2016
7
A Case of Copper Deficiency-Induced Pancytopenia With Maintenance Hemodialysis Outpatient Treated With Polaprezinc. ( 26948531 )
2016
8
A case of asymptomatic pancytopenia with clinical features of hemolysis as a presentation of pernicious anemia. ( 27609735 )
2016
9
Extra pulmonary tuberculosis presenting as fever with massive splenomegaly and pancytopenia. ( 27051579 )
2016
10
Severe pancytopenia due to acute folate deficiency despite normal folate erythrocyte level. ( 27108778 )
2016
11
Evaluation and Management of Chronic Pancytopenia. ( 26933225 )
2016
12
Zotepine-associated vitamin B12 deficiency and pancytopenia. ( 27872328 )
2016
13
Case report of vancomycin-induced pancytopenia. ( 27192600 )
2016
14
An interesting case report of pancytopenia in a HIV seropositive patient-Primary bone marrow non Hodgkin's lymphoma large cell type. ( 27728570 )
2016
15
Fanconi anemia in 55-year-old identical twins first presenting as fatal post-chemotherapy pancytopenia. ( 27427815 )
2016
16
Pancytopenia associated with levetiracetam in an epileptic woman. ( 27927707 )
2016
17
Familial hypertriglyceridemia manifests with pancytopenia and bone marrow pseudoa89Niemann-Pick cells. ( 27453965 )
2016
18
Pregnancy boosts vaccine-induced Bovine Neonatal Pancytopenia-associated alloantibodies. ( 26796141 )
2016
19
Case 1: A newborn with pancytopenia. ( 26941551 )
2016
20
Stuck with pancytopenia in dengue fever: Evoke for hemophagocytic syndrome. ( 26955219 )
2016
21
Study of clinical profile of patients with pancytopenia. ( 27728319 )
2016
22
The Case of the Previously Shaky, Unimmunized, Itchy Infant With Rash and Pancytopenia. ( 26961688 )
2016
23
Acute Lymphoblastic Leukemia Presenting With Pancytopenia Followed by a 14-Month-Long Period of Transient Remission Possibly Supporting the Adrenal Hypothesis of Leukemogenesis. ( 27509378 )
2016
24
Sheehan syndrome presenting as pancytopenia Divendu Bhushan. ( 27727691 )
2016
25
Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose. ( 27920680 )
2016
26
Pancytopenia and Severe Gastrointestinal Toxicities Associated with 5-Fluorouracil in a Patient with Thymidylate Synthase (TYMS) Polymorphism. ( 27774364 )
2016
27
A Patient With Pancytopenia, Intractable Epistaxis, and Metastatic Prostate Cancer: How Correct Diagnosis of Primary Hyperfibrinolysis Helps to Stop the Bleeding. ( 27320762 )
2016
28
A man in his 30s with ulcerative colitis and pancytopenia. ( 27325035 )
2016
29
Pure Red Cell Aplasia in Major ABO-Mismatched Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with Severe Pancytopenia. ( 26921820 )
2016
30
Severe Pancytopenia in a Premature Infant. ( 27884942 )
2016
31
Novel Developments in Leukopenia and Pancytopenia. ( 27866577 )
2016
32
Etiological causes of pancytopenia: A report of 137 cases. ( 27843799 )
2016
33
Pancytopenia caused by visceral leishmaniasis in a patient immunosuppressed after cancer therapy. ( 27811190 )
2016
34
Acute Hepatitis and Pancytopenia in Healthy Infant with Adenovirus. ( 27340581 )
2016
35
Significance of myelodysplastic syndrome-associated somatic variants in the evaluation of patients with pancytopenia and idiopathic cytopenias of undetermined significance. ( 27255165 )
2016
36
Rare case of sarcoidosis presenting with pancytopenia, acute renal failure and hypercalcaemia. ( 26989117 )
2016
37
Bone Marrow Oxalosis in a Patient With Pancytopenia Following Bilateral Nephrectomy. ( 26915618 )
2016
38
Pancytopenia during tyrosine kinase inhibitor treatment - coexistence of chronic myeloid leukemia and visceral leishmaniasis: a case report. ( 27461416 )
2016
39
Methotrexate-induced nonhealing cutaneous ulcers in a nonpsoriatic patient without pancytopenia. ( 27730043 )
2016
40
Neuromyelitis optica accompanied by nephrotic syndrome and autoimmune-related pancytopenia. ( 27237748 )
2016
41
Polyarteritis nodosa. Diagnostic challenges in a patient with cutaneous vasculitis, psoriasis, psoriatic arthritis and pancytopenia: fatal progression after treatment with G-CSF. ( 27123310 )
2016
42
Pancytopenia in a Patient with Rendu-Osler-Weber Syndrome and Uncommon Vascular Abnormalities. ( 27803822 )
2016
43
Pancytopenia in a Patient With Hypothyroidism. ( 27092833 )
2016
44
Rapidly progressive autoimmune pancytopenia successfully treated with steroids. ( 27941280 )
2016
45
Massive paracetamol overdose associated with mitochondrial dysfunction and pancytopenia, without hepatotoxicity. ( 27755150 )
2016
46
Isoniazid Induced Lupus Presenting as Oral Mucosal Ulcers with Pancytopenia. ( 27891378 )
2016
47
Comment on published article in Lupus: Autoimmune myelofibrosis with pancytopenia as a presenting manifestation of systemic lupus erythematosus responsive to mycophenolate mofetil; IVIG in myelofibrosis in SLE. ( 27480990 )
2016
48
Pancytopenia During Parenteral Nutrition. ( 27167899 )
2016
49
Immune pancytopenia after chemotherapy in a patient with diffuse large B-cell lymphoma. ( 27651408 )
2016
50
Ataxia-Pancytopenia Syndrome Is Caused by Missense Mutations in SAMD9L. ( 27259050 )
2016

Variations for Pancytopenia

Expression for Pancytopenia

Search GEO for disease gene expression data for Pancytopenia.

Pathways for Pancytopenia

GO Terms for Pancytopenia

Cellular components related to Pancytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 telomerase holoenzyme complex GO:0005697 8.96 DKC1 TERT
2 Fanconi anaemia nuclear complex GO:0043240 8.8 FANCA FANCC FANCG

Biological processes related to Pancytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 DNA repair GO:0006281 9.73 FANCA FANCC FANCG MGMT
2 telomere maintenance via telomerase GO:0007004 9.46 DKC1 TERT
3 positive regulation of Ras protein signal transduction GO:0046579 9.4 CSF1 EPO
4 positive regulation of nitric-oxide synthase activity GO:0051000 9.37 DHFR TERT
5 cell proliferation GO:0008283 9.35 CSF1 DKC1 EPO MPL THPO
6 interstrand cross-link repair GO:0036297 9.33 FANCA FANCC FANCG
7 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.32 CSF2 EPO
8 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.26 CSF1 CSF2
9 thrombopoietin-mediated signaling pathway GO:0038163 8.62 MPL THPO

Molecular functions related to Pancytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 CSF1 CSF2 CSF3 THPO
2 telomerase RNA binding GO:0070034 9.26 DKC1 TERT
3 telomerase activity GO:0003720 8.96 DKC1 TERT
4 growth factor activity GO:0008083 8.92 CSF1 CSF2 CSF3 THPO

Sources for Pancytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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