MCID: PNC001
MIFTS: 48

Pancytopenia malady

Blood diseases, Rare diseases, Immune diseases categories
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Summaries for Pancytopenia

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Wikipedia:65 Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood... more...

MalaCards based summary: Pancytopenia, also known as pancytopenia nos, is related to splenomegaly and aplastic anemia. An important gene associated with Pancytopenia is TPMT (thiopurine S-methyltransferase), and among its related pathways is One carbon pool by folate. The compounds uridine and 5fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and liver, and related mouse phenotypes are cellular and immune system.

Aliases & Classifications for Pancytopenia

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 27ICD9CM, 57SNOMED-CT, 39NCIt, 34MeSH
See all sources

Pancytopenia, Aliases & Descriptions:

Name: Pancytopenia 8 10 44 62
 
Pancytopenia Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases, Immune diseases


External Ids:

Disease Ontology8 DOID:12450
ICD9CM27 284.1
MeSH34 D010198

Related Diseases for Pancytopenia

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Diseases in the Pancytopenia family:

Pancytopenia Due to Ikzf1 Mutations

Diseases related to Pancytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 249)
idRelated DiseaseScoreTop Affiliating Genes
1splenomegaly30.6GBA, MPL
2aplastic anemia30.5DKC1, MPL
3acute lymphoblastic leukemia30.1MPL, TPMT, IKZF1
4neutropenia30.1MPL, TPMT
5thrombocytopenia29.9TPMT, MPL, GBA
6leukemia29.6GBA, MPL, TPMT, IKZF1, TCN2
7deficiency anemia29.3TCN2, GBA, MPL, TPMT
8arthritis10.4
9hepatitis10.4
10rheumatoid arthritis10.4
11tuberculosis10.4
12myelodysplastic syndromes10.3
13dyskeratosis congenita10.3
14brucellosis10.3
15miliary tuberculosis10.3
16vitamin b12 deficiency10.3
17lupus erythematosus10.3
18fanconi's anemia10.2
19malaria10.2
20thymoma10.2
21myelofibrosis10.2
22hypersplenism10.2
23megaloblastic anemia10.2
24visceral leishmaniasis10.2
25graves' disease10.2
26leishmaniasis10.2
27cerebellar hypoplasia10.2
28crohn's disease10.1
29hepatitis b10.1
30hereditary spherocytosis10.1
31subacute bacterial endocarditis10.1
32endocarditis10.1
33hyperthyroidism10.1
34lymphoblastic leukemia10.1
35peritonitis10.1
36pneumonia10.1
37myelocerebellar disorder10.1
38acute lymphoblastic leukemia, childhood10.1TPMT, IKZF1
39graft versus host disease10.1
40hemophagocytic lymphohistiocytosis10.1
41paroxysmal nocturnal hemoglobinuria10.1
42shwachman-diamond syndrome10.1
43systemic lupus erythematosus10.1
44gaucher's disease10.1
45hemoglobinuria10.1
46microcephaly10.1
47breast cancer10.1
48histoplasmosis10.1
49vasculitis10.1
50bone marrow necrosis10.1

Graphical network of the top 20 diseases related to Pancytopenia:



Diseases related to pancytopenia

Symptoms for Pancytopenia

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Drugs & Therapeutics for Pancytopenia

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Drug clinical trials:

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Search NIH Clinical Center for Pancytopenia

Genetic Tests for Pancytopenia

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Anatomical Context for Pancytopenia

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MalaCards organs/tissues related to Pancytopenia:

32
Bone, Bone marrow, Liver, Kidney, T cells, Breast, Myeloid, B cells, Spleen, Pancreas, Thyroid, Monocytes, Whole blood, Lymph node, Spinal cord, Heart, Colon, Lung, Skin, Ovary

Animal Models for Pancytopenia or affiliated genes

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MGI Mouse Phenotypes related to Pancytopenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.2IKZF1, DKC1, MPL, GBA
2MP:00053877.9GBA, MPL, DKC1, IKZF1
3MP:00053977.8GBA, MPL, TPMT, DKC1, IKZF1
4MP:00053787.7GBA, MPL, TPMT, DKC1, IKZF1
5MP:00107687.6IKZF1, DKC1, TPMT, MPL, GBA

Publications for Pancytopenia

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Articles related to Pancytopenia:

(show top 50)    (show all 569)
idTitleAuthorsYear
1
Dyskeratosis congenita caused by a novel TERT point mutation in siblings with pancytopenia and exudative retinopathy. (25067791)
2014
2
Pancytopenia from severe cobalamin (vitamin B12) deficiency in Johanson-Blizzard syndrome. (23900243)
2013
3
Unremitting pyrexia, pancytopenia, hepatosplenomegaly, and extreme hyperferritinemia. (23495040)
2013
4
A 13-year-old girl with pancytopenia. Catastrophic antiphospholipid syndrome. (23556525)
2013
5
The common causes leading to pancytopenia in patients presenting to tertiary care hospital. (24353701)
2013
6
Congenital amegakaryocytic thrombocytopenia (CAMT) presenting as severe pancytopenia in the first month of life. (23625800)
2013
7
Calf-level factors associated with bovine neonatal pancytopenia - a multi-country case-control study. (24312485)
2013
8
Imported case of visceral leishmaniasis presenting as pancytopenia in a Norwegian patient treated with methotrexate and etanercept for psoriasis arthritis. (22886470)
2013
9
Hematologic Recovery of Pancytopenia after Treatment of Hashimoto's Thyroiditis and Primary Adrenal Insufficiency. (23626971)
2013
10
Clinical and magnetic resonance imaging (MRI) findings of idiopathic aplastic pancytopenia in a dog treated with cyclosporine and azathioprine. (23024391)
2012
11
Parvovirus B19 presenting with persistent pancytopenia in a patient of T-ALL post induction chemotherapy diagnosed on bone marrow examination. (21934234)
2011
12
Successful use of tocilizumab in a patient with rheumatoid arthritis following severe pancytopenia during etanercept therapy. (21946465)
2011
13
Spontaneous tumor lysis syndrome with resolution of pancytopenia and disappearance of lymphadenopathy in a patient with peripheral T cell lymphoma unspecified. (21347646)
2011
14
Fulminant pancytopenia due to cytomegalovirus infection in an immunocompetent adult. (20563446)
2010
15
Amiodarone-induced bone marrow granulomas: an unusual cause of reversible pancytopenia. (22184519)
2010
16
Pancytopenia in hospitalized children: a five-year review. (20523248)
2010
17
Acute severe pancytopenia associated with clopidogrel. (19367789)
2009
18
Unusual pancytopenia secondary to haemophagocytosis syndrome in rickettsioses. (19446860)
2009
19
Fatal pancytopenia in a hemodialysis patient after treatment with low-dose methotrexate. (19502905)
2009
20
A 15-year-old girl with pancytopenia and congenital defects. (19584579)
2009
21
A study of clinico-haematological profiles of pancytopenia in children. (18820199)
2008
22
Enoxaparin-induced reversible pancytopenia. (17911201)
2007
23
Apparent vaccine-thimerosal induced hypersensitivity, myelodysplastic syndrome and pancytopenia. (19734619)
2007
24
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease. (16880012)
2007
25
The incidence of pancytopenia in patients taking leflunomide alone or with methotrexate. (16634119)
2007
26
A 14-year-old girl with pancytopenia. (16493913)
2006
27
Serious pancytopenia from methotrexate treatment of psoriatic arthritis. (16635735)
2006
28
Pancytopenia in untreated patients with Graves' disease. (16646688)
2006
29
Meningoencephalitis, pancytopenia, pulmonary insufficiency and splenic abscess in a patient with brucellosis. (16598314)
2006
30
Metastatic malignant melanoma presenting as pancytopenia in a three-year-old boy. (15800910)
2005
31
Systemic lupus erythematosus presenting with pancytopenia due to bone marrow myelofibrosis in a 22-year-old male. (16163223)
2004
32
Fatal immune-mediated pancytopenia and a TRALI-like syndrome associated with high titers of recipient-type antibodies against donor-derived peripheral blood cells after allogeneic bone marrow transplantation following dose reduced conditioning. (15136241)
2004
33
A case report of pancytopenia with quetiapine use. (14609812)
2003
34
Challenges with linezolid therapy and reversible pancytopenia. (12811516)
2003
35
A young woman with fever and pancytopenia. (14506825)
2003
36
Girl with combined cellular immunodeficiency, pancytopenia, malformations, deletion 11q23.3 --> qter, and trisomy 8q24.3 --> qter. (11920839)
2002
37
Methotrexate-induced pancytopenia and death in the Japanese literature. (24383840)
2002
38
Colchicine induced toxicity and pancytopenia at usual doses and treatment with granulocyte colony-stimulating factor. (11361215)
2001
39
Pancytopenia and colitis with Clostridium difficile in a rheumatoid arthritis patient taking methotrexate, antibiotics and non-steroidal anti-inflammatory drugs. (11254248)
2001
40
Pancytopenia after treatment of keratoacanthoma by single lesional methotrexate infiltration. (11493112)
2001
41
Pyrexia and pancytopenia with unusual host immune response. (10727577)
2000
42
Lethal pancytopenia associated with chilblain lupus erythematosus. (11200851)
2000
43
Fever, rash, and pancytopenia following vancomycin rechallenge in the presence of ceftazidime. (10676837)
2000
44
Severe pancytopenia after leflunomide in rheumatoid arthritis. (10989684)
2000
45
Bilateral renal agenesis, cardiac hypertrophy and pancytopenia, a new syndrome? (9823496)
1998
46
Thymoma-associated pancytopenia: effectiveness of cyclosporine A. (9829850)
1998
47
"Emergency hepatectomy" in a 16-month-old boy with a hepatoblastoma, severe cytomegalovirus-induced pancytopenia, and intractable diarrhea. (9880755)
1998
48
The Hoyeraal-Hreidarsson syndrome: the fourth case of a separate entity with prenatal growth retardation, progressive pancytopenia and cerebellar hypoplasia. (7607282)
1995
49
Serum monocyte colony-stimulating factor, erythropoietin and interleukin-6 in relation to pancytopenia in hairy cell leukemia. (1625496)
1992
50
Inhibition of bone marrow stem cell growth in vitro by methylmalonic acid: a mechanism for pancytopenia in a patient with methylmalonic acidemia. (7254944)
1981

Variations for Pancytopenia

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Expression for genes affiliated with Pancytopenia

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Expression patterns in normal tissues for genes affiliated with Pancytopenia

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Pathways for genes affiliated with Pancytopenia

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Pathways related to Pancytopenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
One Carbon Metabolism37
dTMP de novo biosynthesis (mitochondrial)37
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate37
Trans-sulfuration and one carbon metabolism37
methionine salvage37
Methionine metabolism60
9.4TCN2, TPMT

Compounds for genes affiliated with Pancytopenia

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 28IUPHAR
See all sources

Compounds related to Pancytopenia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1uridine44 24 1111.7TPMT, DKC1
25fluorouracil449.5MPL, TPMT
3folate449.0TPMT, TCN2, IKZF1
4aspirin44 50 28 2412.0GBA, MPL
5alanine449.0IKZF1, MPL, TPMT
6methotrexate50 44 1110.9GBA, TPMT

GO Terms for genes affiliated with Pancytopenia

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Cellular components related to Pancytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomal lumenGO:0432029.0TCN2, GBA

Biological processes related to Pancytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to testosteroneGO:0335749.2TPMT, GBA

Products for genes affiliated with Pancytopenia

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Sources for Pancytopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet