MCID: PND004
MIFTS: 41

Pandas malady

Rare diseases, Neuronal diseases categories
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Summaries for Pandas

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Wikipedia:65 Panda or Panda bear most often refers to: more...

MalaCards based summary: Pandas, also known as pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, is related to chorea and neuroectodermal tumor. An important gene associated with Pandas is FSHB (follicle stimulating hormone, beta polypeptide), and among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and CFTR translational fidelity class I mutations . The compounds mibg and spec-t have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and skin.

Aliases & Classifications for Pandas

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Pandas, Aliases & Descriptions:

Name: Pandas 42 48
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections 42
 
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections 48
Pediatric Autoimmune Disorders Associated with Streptococcus Infections 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
pandas:
Inheritance: Sporadic; Age of onset: Childhood


Related Diseases for Pandas

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Graphical network of the top 20 diseases related to Pandas:



Diseases related to pandas

Symptoms for Pandas

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Drugs & Therapeutics for Pandas

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Drug clinical trials:

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Genetic Tests for Pandas

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Anatomical Context for Pandas

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MalaCards organs/tissues related to Pandas:

32
Bone, Brain, Skin

Animal Models for Pandas or affiliated genes

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Publications for Pandas

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Articles related to Pandas:

(show top 50)    (show all 185)
idTitleAuthorsYear
1
Disordered Eating and Food Restrictions in Children with PANDAS/PANS. (25329522)
2014
2
Sydenham Chorea and PANDAS in South Africa: Review of Evidence and Recommendations for Management in Resource-Poor Countries. (25227516)
2014
3
A link between perianal strep and pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS). (24763762)
2014
4
A 'combined framework' approach to developing a patient decision aid: the PANDAs model. (25341370)
2014
5
Evaluation of autoimmune phenomena in patients with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). (25151976)
2014
6
Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation. (23242367)
2013
7
A case of PANDAS with Kleine-Levin type periodic hypersomnia. (22261244)
2012
8
Fecal near infrared spectroscopy to discriminate physiological status in giant pandas. (22719982)
2012
9
Supplemental iodine as a key to reproduction in pandas? (22691201)
2012
10
Dental abnormalities in eight captive giant pandas (Ailuropoda melanoleuca) in China. (21906751)
2012
11
Significant genetic boundaries and spatial dynamics of giant pandas occupying fragmented habitat across southwest China. (21251112)
2011
12
Old-growth forest is what giant pandas really need. (21227979)
2011
13
Conservation implications of drastic reductions in the smallest and most isolated populations of giant pandas. (20408868)
2010
14
Serosurvey of selected viruses in captive giant pandas (Ailuropoda melanoleuca) in China. (19913371)
2010
15
Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study. (19152896)
2009
16
Phenotypic and genotypic characterisation of antimicrobial resistance in faecal bacteria from 30 Giant pandas. (19168331)
2009
17
Serum autoantibodies measured by immunofluorescence confirm a failure to differentiate PANDAS and Tourette syndrome from controls. (18823914)
2009
18
Chorea-St. Vitus, Sydenham or pandas? (20329434)
2009
19
The PANDAS subgroup of tic disorders and childhood-onset obsessive-compulsive disorder. (19913659)
2009
20
Potential chemosignals in the anogenital gland secretion of giant pandas, Ailuropoda melanoleuca, associated with sex and individual identity. (18293041)
2008
21
PANDAS and paroxysms: a case of conversion disorder? (18294094)
2008
22
What every psychiatrist should know about PANDAS: a review. (18495013)
2008
23
PANDAS in siblings: a common risk? (17539928)
2007
24
Nucleotide sequence of cDNA encoding the mitochondrial precursor protein of the ATPase inhibitor from the giant panda (Ailuropoda melanoleuca). (17822358)
2007
25
Autoimmune neuropsychiatric disorders associated with streptococcal infection: Sydenham chorea, PANDAS, and PANDAS variants. (16970875)
2006
26
Implications of the functional anatomy of the hand and forearm of Ailurus fulgens (Carnivora, Ailuridae) for the evolution of the 'false-thumb' in pandas. (17118063)
2006
27
How do giant pandas (Ailuropoda melanoleuca) respond to varying properties of enrichments? A comparison of behavioral profiles among five enrichment items. (16131261)
2005
28
Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls. (16207842)
2005
29
Lions, tigers, and pandas, oh my. (15955882)
2005
30
Atrial natriuretic peptide induces an acrosome reaction in giant panda spermatozoa and enhances their penetration of salt-stored porcine oocytes. (16139606)
2005
31
Distinguishing PANDAS from Sydenham's chorea: case report and review of the literature. (15261885)
2004
32
The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) etiology for tics and obsessive-compulsive symptoms: hypothesis or entity? Practical considerations for the clinician. (15060240)
2004
33
Echocardiographic findings in the PANDAS subgroup. (15545618)
2004
34
Chemical cues identify gender and individuality in Giant pandas (Ailuropoda melanoleuca). (12918929)
2003
35
Behavioral and developmental consequences of early rearing experience for captive giant pandas (Ailuropoda melanoleuca). (14498799)
2003
36
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). (11791105)
2002
37
Late-onset PANDAS syndrome with abdominal muscle involvement. (12138313)
2002
38
Two cases of ADHD following GABHS infection: a PANDAS subgroup? (12410069)
2002
39
Hyperostotic bone disease in red pandas (Ailurus fulgens). (12462494)
2002
40
Antistreptolysin-O titers: implications for adult PANDAS. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. (11823288)
2002
41
Prospective identification and treatment of children with pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS). (11929370)
2002
42
Avascular necrosis of the femoral heads in a red panda (Ailurus fulgens fulgens): possible Legg-Calve-Perthes disease. (12462497)
2002
43
Ecological degradation in protected areas: the case of Wolong Nature Reserve for giant pandas. (11292872)
2001
44
Ecology. Giant pandas in a changing landscape. (11711657)
2001
45
Giant pandas discriminate individual differences in conspecific scent. (10328790)
1999
46
Dermatophytosis in red pandas (Ailurus fulgens fulgens): a review of 14 cases. (10749446)
1999
47
PANDAS: the search for environmental triggers of pediatric neuropsychiatric disorders. Lessons from rheumatic fever. (9733286)
1998
48
Acute myoclonus secondary to group A beta-hemolytic streptococcus infection: A PANDAS variant. (9796759)
1998
49
IVF project stirs debate over how to preserve pandas. (8658127)
1996
50
Canine distemper virus infection in lesser pandas (Ailurus fulgens). (2601238)
1989

Variations for Pandas

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Expression for genes affiliated with Pandas

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Expression patterns in normal tissues for genes affiliated with Pandas

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Pathways for genes affiliated with Pandas

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Pathways related to Pandas according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6RPS19, RPS25
2
Show member pathways
Cytoplasmic Ribosomal Proteins37
9.1RPLP1, RPS19, RPS25
3
Show member pathways
9.1RPLP1, RPS19, RPS25
4
Show member pathways
8.8FSHB, RPS25, RPS19, RPLP1
5
Show member pathways
8.6NPPA, RPLP1, RPS19, RPS25
68.6RPS25, RPS19, RPLP1, NPPA

Compounds for genes affiliated with Pandas

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Compounds related to Pandas according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1mibg449.6NPPA, ENO2
2spec-t449.6NPPA, ENO2
3propofol44 50 1111.5ENO2, NPPA
45-hydroxyindoleacetic acid44 2410.2ENO2, CEACAM3
5sialic acid449.0FSHB, CEACAM3, ENO2
6hematoxylin448.9ENO2, CEACAM3
7steroid448.9FSHB, CEACAM3, CSNK2A2, CRYAB
8dopamine44 28 24 1111.8CSNK2A2, ENO2, NPPA
9paraffin448.7ENO2, CRYAB, CEACAM3
10thymidine44 249.6CEACAM3, CSNK2A2, CRYAB, ENO2
11acth448.6NPPA, ENO2, CEACAM3, FSHB
12creatinine448.6NPPA, ENO2, CEACAM3
13aspartate448.6ENO2, CRYAB, CSNK2A2, CEACAM3
14progesterone44 28 61 24 1112.4FSHB, CEACAM3, CSNK2A2, CRYAB, ENO2
15estrogen448.3NPPA, ENO2, CSNK2A2, CEACAM3, FSHB
16calcium44 50 24 1110.9FSHB, CEACAM3, CSNK2A2, CRYAB, ENO2, NPPA

GO Terms for genes affiliated with Pandas

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Cellular components related to Pandas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ribosomeGO:0058409.6RPS19, RPS25
2cytosolic small ribosomal subunitGO:0226279.3RPS19, RPS25
3cytosolGO:0058297.7ENO2, RPS25, RPS19, RPLP1, CSNK2A2, CRYAB

Biological processes related to Pandas according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1ribosomal small subunit assemblyGO:0000289.9RPS19, RPS25
2female pregnancyGO:0075659.8NPPA, FSHB
3viral transcriptionGO:0190839.3RPLP1, RPS19, RPS25
4translational terminationGO:0064159.3RPLP1, RPS19, RPS25
5translational elongationGO:0064149.3RPS25, RPS19, RPLP1
6SRP-dependent cotranslational protein targeting to membraneGO:0066149.3RPLP1, RPS19, RPS25
7viral life cycleGO:0190589.3RPS25, RPS19, RPLP1
8nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:0001849.2RPLP1, RPS19, RPS25
9translational initiationGO:0064139.2RPS25, RPS19, RPLP1
10mRNA metabolic processGO:0160719.1RPS25, RPS19, RPLP1
11RNA metabolic processGO:0160709.0RPLP1, RPS19, RPS25
12cellular protein metabolic processGO:0442678.9RPLP1, RPS19, RPS25, FSHB
13translationGO:0064128.8RPLP1, RPS19, RPS25
14gene expressionGO:0104678.7RPS25, RPS19, RPLP1, NPPA

Molecular functions related to Pandas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.8NPPA, FSHB
2structural constituent of ribosomeGO:0037358.8RPLP1, RPS19, RPS25

Products for genes affiliated with Pandas

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  • Antibodies
  • Proteins
  • Lysates

Sources for Pandas

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet