MCID: PND004
MIFTS: 34

Pandas

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Pandas

MalaCards integrated aliases for Pandas:

Name: Pandas 49 55
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections 49 55
Pediatric Autoimmune Disorders Associated with Streptococcus Infections 49 55
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections 49
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection 36
Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus 49

Characteristics:

Orphanet epidemiological data:

55
pandas
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Orphanet 55 ORPHA66624
KEGG 36 H01452

Summaries for Pandas

NIH Rare Diseases : 49 PANDAS is an acronym for Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus. It is used to describe a condition in children whose symptoms of obsessive-compulsive disorder (OCD) or a tic disorder (i.e. Tourette syndrome) are worsened by group A streptococcal (GAS) infections. The underlying cause of PANDAS is unclear, but studies suggest that a strep infection causes an abnormal immune response resulting in neuropsychiatric symptoms. The association between PANDAS and GAS is controversial because the cause has not been proven. Management is centered on providing antibiotics for GAS infection, and medication or behavioral therapy for neuropsychiatric symptoms. Last updated: 7/5/2016

MalaCards based summary : Pandas, also known as pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections, is related to alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity and choreatic disease. An important gene associated with Pandas is ENO2 (Enolase 2). The drugs Celecoxib and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include brain, myeloid and prostate.

Wikipedia : 72 The giant panda is an animal in the bear family... more...

Related Diseases for Pandas

Diseases related to Pandas via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4
2 choreatic disease 10.1
3 chorea, childhood-onset, with psychomotor retardation 10.1
4 gilles de la tourette syndrome 10.1
5 vaginitis 10.0
6 polyarteritis nodosa, childhood-onset 10.0
7 sydenham chorea 10.0
8 obsessive-compulsive disorder 9.9
9 bulimia nervosa 2 9.8
10 wilson disease 9.8
11 aging 9.8
12 pervasive developmental disorder 9.8
13 body mass index quantitative trait locus 7 9.7
14 lyme disease 9.7
15 myoclonus 9.7
16 avascular necrosis of femoral head, primary, 1 9.7
17 dementia 9.7
18 autoimmune disease 9.7
19 disease of mental health 9.7
20 body mass index quantitative trait locus 12 9.7
21 rheumatic fever 9.7
22 kleine-levin hibernation syndrome 9.7
23 body mass index quantitative trait locus 14 9.7
24 conversion disorder 9.7
25 legg-calve-perthes disease 9.7
26 body mass index quantitative trait locus 18 9.7
27 dermatitis 9.7
28 rheumatic fever-related antigen 9.7
29 tic disorder 9.7
30 cohen-gibson syndrome 9.7
31 gastric dilatation 9.7
32 body mass index quantitative trait locus 11 9.7
33 twin-to-twin transfusion syndrome 9.7
34 pancreatitis 9.7
35 neuronitis 9.7
36 body mass index quantitative trait locus 9 9.7
37 influenza 9.7
38 body mass index quantitative trait locus 8 9.7
39 body dysmorphic disorder 9.7
40 eating disorder 9.7
41 anxiety 9.7
42 stuttering 9.7
43 dermatophytosis 9.7
44 autoimmune disease 1 9.7
45 dirofilariasis 9.7
46 hypersomnia 9.7

Graphical network of the top 20 diseases related to Pandas:



Diseases related to Pandas

Symptoms & Phenotypes for Pandas

Drugs & Therapeutics for Pandas

Drugs for Pandas (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 106)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
2
Ibuprofen Approved Phase 4 15687-27-1 3672
3
Naproxen Approved, Vet_approved Phase 4 22204-53-1 156391 1302
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5
Everolimus Approved Phase 4 159351-69-6 6442177
6
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
7
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
8
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 6436030 5284616
9 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2
10 gamma-Globulins Phase 4,Phase 3,Phase 2
11 Peripheral Nervous System Agents Phase 4,Phase 3
12 Anti-Bacterial Agents Phase 4,Phase 2
13 Anti-Infective Agents Phase 4,Phase 2
14 Immunoglobulins Phase 4,Phase 3,Phase 2
15 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
16 Antibiotics, Antitubercular Phase 4,Phase 2
17 Antibodies Phase 4,Phase 3,Phase 2
18 Chlorhexidine gluconate Phase 4
19 Analgesics Phase 4,Phase 3
20 Cyclooxygenase 2 Inhibitors Phase 4
21 Cyclooxygenase Inhibitors Phase 4
22 Analgesics, Non-Narcotic Phase 4,Phase 3
23 Dermatologic Agents Phase 4
24 Disinfectants Phase 4
25 Antifungal Agents Phase 4
26 Immunosuppressive Agents Phase 4,Phase 2
27 Anti-Infective Agents, Local Phase 4
28 Anti-Inflammatory Agents Phase 4
29 Anti-Inflammatory Agents, Non-Steroidal Phase 4
30 Antirheumatic Agents Phase 4
31
Pantoprazole Approved Phase 3 102625-70-7 4679
32
Goserelin Approved Phase 3 65807-02-5 5311128 47725
33
Eslicarbazepine acetate Approved Phase 3 236395-14-5, 75970-99-9 123618
34
Dexmedetomidine Approved, Vet_approved Phase 3 76631-46-4, 113775-47-6 5311068 56032 68602
35
Sevoflurane Approved, Vet_approved Phase 3 28523-86-6 5206
36
Remifentanil Approved Phase 3 132875-61-7 60815
37
Azacitidine Approved, Investigational Phase 3,Phase 2 320-67-2 9444
38
Arsenic trioxide Approved, Investigational Phase 3,Phase 2 1327-53-3 518740
39
Decitabine Approved, Investigational Phase 3,Phase 2 2353-33-5 451668
40
Serotonin Phase 3,Phase 2 50-67-9 5202
41 Adrenergic Agents Phase 3
42 Adrenergic Agonists Phase 3
43 Serotonin Agents Phase 3,Phase 2
44 Serotonin Uptake Inhibitors Phase 3,Phase 2
45 Neurotransmitter Agents Phase 3,Phase 2
46 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2
47 Autonomic Agents Phase 3
48 Central Nervous System Depressants Phase 3
49 Sodium Channel Blockers Phase 3
50 Gastrointestinal Agents Phase 3

Interventional clinical trials:

(show all 48)

# Name Status NCT ID Phase Drugs
1 Comparison of BuMA eG Based BioDegradable Polymer Stent With EXCEL Biodegradable Polymer Sirolimus-eluting Stent in "Real-World" Practice Completed NCT02017275 Phase 4
2 Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections Completed NCT00001658 Phase 4 Amoxicillin
3 Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen Completed NCT00346216 Phase 4 celecoxib;Ibuprofen;Naproxen
4 A Study to Evaluate the Benefit of Octagam 5%® in Subjects With Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) Active, not recruiting NCT03348618 Phase 4
5 Intravenous Immunoglobulin for PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections) Unknown status NCT01281969 Phase 3 Gamunex Intravenous Immunoglobulin;Placebo
6 One Month Degarelix/Comparator Treatment for Prostate Cancer in Chinese Population Completed NCT01744366 Phase 3 Degarelix;Goserelin
7 Safety and Efficacy of Eslicarbazepine Acetate Monotherapy in Subjects With Partial Epilepsy Not Well Controlled by Current Antiepileptic Drugs Completed NCT00866775 Phase 3 Eslicarbazepine acetate;Eslicarbazepine acetate
8 Eslicarbazepine Acetate Monotherapy Long Term Study Completed NCT00910247 Phase 3 Eslicarbazepine acetate
9 A Study to Compare the Long-term Outcomes After Two Different Anaesthetics Recruiting NCT03089905 Phase 3 Sevoflurane;Remifentanil;Dexmedetomidine
10 Comparison of Insulin Tregopil (IN-105) With Insulin Aspart in Type 2 Diabetes Mellitus Patients Recruiting NCT03430856 Phase 2, Phase 3 Insulin Tregopil;Insulin Aspart
11 A Trial of Two Fixed Doses of ZX008 (Fenfluramine HCl) in Children and Young Adults With Dravet Syndrome Recruiting NCT02682927 Phase 3 ZX008 (Fenfluramine Hydrochloride);Matching Placebo
12 A Study to Investigate the Efficacy and Safety of ZX008 (Fenfluramine Hydrochloride) as an Adjunctive Therapy in Children and Adults With Lennox-Gastaut Syndrome Recruiting NCT03355209 Phase 3 ZX008 02 and 0.8 mg/kg/day
13 Efficacy, Safety, and Tolerability of Multiple Dosing Regimens of Oral AGN-241689 in Episodic Migraine Prevention Recruiting NCT02848326 Phase 2, Phase 3 AGN-241689;Placebo-matching AGN-241689
14 Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - single low dose;QPI-1007 Injection - single high dose;QPI-1007 Injection - multiple low dose;QPI-1007 Injection - multiple high dose
15 An Open-Label Extension Trial to Assess the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride HCl) Oral Solution in Children and Young Adults With Dravet Syndrome Enrolling by invitation NCT02823145 Phase 3 ZX008 (Fenfluramine Hydrochloride)
16 Decitabine and Arsenic Trioxide for Myelodysplastic Syndrome(MDS) Not yet recruiting NCT03377725 Phase 3 Decitabine;Arsenic Trioxide
17 Clinical Study, Multicenter, Randomized With 2 Arms of Pantoprazole + Domperidone and Pantoprazole Isolated at the Gastroesophageal Reflux Disease Withdrawn NCT01710462 Phase 3 Pantoprazole + Domperidone;Pantozol®
18 Management of Eczema by Specific Probiotic Strains Withdrawn NCT01230190 Phase 3
19 Antibiotic Treatment and Intravenous Immunoglobulin Trial for PANDAS Unknown status NCT01769027 Phase 2 Sertraline+Antibiotic (penicillin/azithromycin);Sertraline+placebo
20 Antibiotic Treatment Trial for the PANDAS/PANS Phenotype Completed NCT01617083 Phase 2 Azithromycin;Placebo
21 Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup) Completed NCT00001359 Phase 2 Penicillin or Placebo
22 The Alberta Diet: Effectiveness Study Completed NCT01625507 Phase 2
23 Study of I Line FOLFOX + Panitumumab vs 5FU + Panitumumab in RAS and BRAF WT Metastatic Colorectal Cancer Elderly Patients Recruiting NCT02904031 Phase 2 5-fluorouracil;oxaliplatin;l-leucovorin;panitumumab
24 Neoadjuvant mFolfirinox With or Without Preoperative Concomitant Chemoradiotherapy in Patients With Borderline Resectable Pancreatic Carcinoma (PANDAS-PRODIGE 44) Recruiting NCT02676349 Phase 2 mFolfirinox;Adjuvant chemotherapy
25 Neoadjuvant Capecitabine, Oxaliplatin, Docetaxel and Atezolizumab in Resectable Gastric and GE-junction Cancer (PANDA) Not yet recruiting NCT03448835 Phase 2 Atezolizumab;Capecitabine;Oxaliplatin;Docetaxel
26 Decitabine,Cytarabine and Arsenic Trioxide for Acute Myeloid Leukemia With p53 Mutations Not yet recruiting NCT03381781 Phase 2 Decitabine;Arsenic Trioxide;Cytarabine
27 A Parp Inhibitor (BMN 673) for Inoperable Advanced eNDometrial cAncer Withdrawn NCT02127151 Phase 2 BMN 673
28 Prospective Assessment in Newborns for Diabetes Autoimmunity Unknown status NCT00649246
29 Prognostic Accuracy of Coronary CT and Dobutamine Stress Echocardiography in Patient Undergoing Non-cardiac Surgery Unknown status NCT02250963
30 Panda: Evaluation of a Smartphone-based Perioperative Pain Assessment Tool Completed NCT01610882
31 Feasibility Study for PANDAS Completed NCT00754897
32 PANDA (Pediatric Anesthesia & NeuroDevelopment Assessment) Study Completed NCT00881764
33 Diffusion MRI for Pancreatic Adenocarcinoma Completed NCT02896946
34 Pantoprazole 20/40 mg in the Treatment of Symptomatic Reflux Disease With Focus on Sleep Disorders Completed NCT00830115 Pantoprazole
35 Characterization of Childhood-Onset Obsessive-Compulsive Disorder Completed NCT00044239
36 Cancer Detection in Pancreatic Cysts Completed NCT00222898
37 Intervention for Resistant Pregnant Smokers Completed NCT00005697
38 Primary Prevention of Atopic Disease by Perinatal Administration of Probiotics Completed NCT00200954
39 PANS - A Detailed Study of the Patients, Their Symptoms, Biomarkers and Treatment Offered in a Scandinavian Cohort Completed NCT02190292
40 PANDA-Regional Feasibility Study of a Smartphone Pain Management Application Recruiting NCT03369392
41 Parameters Analysis in Neurosurgical Critical Patients Through Big Data Acquisition Recruiting NCT03087981
42 Patient's Feelings After Receiving a Diagnosis of Age-related Macular Degeneration Recruiting NCT03035461
43 Prenatal DHA and Neurofunctional Development Recruiting NCT02709239
44 Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS Recruiting NCT02889016
45 Pancreatoduodenectomy With or Without Ligamentum Teres Wrap Around Gastroduodenal Artery Stump for Prevention of Pancreatic Hemorrhage Recruiting NCT02588066
46 Prone or Supine Effect After Caesarean Delivery on Respiratory Outcomes in Full Term Infants Recruiting NCT02692573
47 Sodium Imbalance in Traumatic Brain Injury Patients: Prevalence, Predictors and Prognostic Significance in a Tertiary Care Centre Recruiting NCT02940834
48 RESIST: Understanding the Role of Depression in Heart Disease Active, not recruiting NCT02657798

Search NIH Clinical Center for Pandas

Genetic Tests for Pandas

Anatomical Context for Pandas

MalaCards organs/tissues related to Pandas:

38
Brain, Myeloid, Prostate, Liver, Heart, Breast, Testes

Publications for Pandas

Articles related to Pandas:

(show top 50) (show all 266)
# Title Authors Year
1
Dietary changes during weaning shape the gut microbiota of red pandas (<i>Ailurus fulgens</i>). ( 29399361 )
2018
2
Blood Lead Levels in Captive Giant Pandas. ( 29177695 )
2018
3
Long-term distribution and habitat changes of protected wildlife: giant pandas in Wolong Nature Reserve, China. ( 29423692 )
2018
4
Treatment of PANDAS and PANS: a systematic review. ( 29309797 )
2018
5
Frequency of antimicrobial resistance and integron gene cassettes in Escherichia coli isolated from giant pandas (Ailuropoda melanoleuca) in China. ( 29414607 )
2018
6
Amdoparvovirus Infection in Red Pandas ( Ailurus fulgens). ( 29433401 )
2018
7
An expert opinion on PANDAS/PANS: highlights and controversies. ( 28498087 )
2017
8
Changes in urinary androgen concentration indicate that male giant pandas (Ailuropoda melanoleuca) respond to impending female oestrus during and outside the typical spring breeding season. ( 28768568 )
2017
9
Ancylostoma ailuropodae n. sp. (Nematoda: Ancylostomatidae), a new hookworm parasite isolated from wild giant pandas in Southwest China. ( 28576124 )
2017
10
The normal vaginal and uterine bacterial microbiome in giant pandas (Ailuropoda melanoleuca). ( 28454704 )
2017
11
Lineage-specific evolution of bitter taste receptor genes in the giant and red pandas implies dietary adaptation. ( 29168616 )
2017
12
Inbreeding and inbreeding avoidance in wild giant pandas. ( 28792640 )
2017
13
Seasonal variation in nutrient utilization shapes gut microbiome structure and function in wild giant pandas. ( 28904137 )
2017
14
Impact of PANS and PANDAS Exacerbations on Occupational Performance: A Mixed-Methods Study. ( 28422636 )
2017
15
Musical Interests and Talent: Twin Jazz Musicians and Twin Studies/Twin Research: Loss of a Preterm Multiple; Conjoined Twin Conception; Depression in Fathers of Twins; Twin-to-Twin Transfusion Syndrome/Twin News: High-Achieving Twins; Twin Children of a Tennis Star; Conjoined Twin Separation; Twin Delivery to a Giant Panda. ( 29103407 )
2017
16
Population genetics of Enterocytozoon bieneusi in captive giant pandas of China. ( 29047380 )
2017
17
Giant pandas, gender lawsuit and more disaster havoc. ( 28959983 )
2017
18
Conservation planning beyond giant pandas: the need for an innovative telecoupling framework. ( 28303460 )
2017
19
Longitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS). ( 29119300 )
2017
20
Giant pandas can discriminate the emotions of human facial pictures. ( 28814756 )
2017
21
Phenological changes in bamboo carbohydrates explain the preference for culm over leaves by giant pandas (Ailuropoda melanoleuca) during spring. ( 28614359 )
2017
22
Unusual arsenic metabolism in Giant Pandas. ( 28950121 )
2017
23
Long Noncoding RNA PANDA Positively Regulates Proliferation of Osteosarcoma Cells. ( 28011477 )
2017
24
Analysis of the influence of living environment and age on vaginal fungal microbiome in giant pandas (Ailuropoda melanoleuca) by high throughput sequencing. ( 29294370 )
2017
25
Association of Streptococcal Throat Infection With Mental Disorders: Testing Key Aspects of the PANDAS Hypothesis in a Nationwide Study. ( 28538981 )
2017
26
Assessing vulnerability of giant pandas to climate change in the Qinling Mountains of China. ( 28616195 )
2017
27
Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum. ( 29233751 )
2017
28
PBDEs (polybrominated diphenyl ethers) pose a risk to captive giant pandas. ( 28431316 )
2017
29
Virome comparisons in wild-diseased and healthy captive giant pandas. ( 28780905 )
2017
30
Isolation and identification of culturable fungi from the genitals and semen of healthy giant pandas (Ailuropoda melanoleuca). ( 29157237 )
2017
31
China: Rail network must protect giant pandas. ( 28516920 )
2017
32
Urinary profiles of luteinizing hormone, estrogen and progestagen during the estrous and gestational periods in giant pandas (Ailuropda melanoleuca). ( 28091600 )
2017
33
PANDAS in otolaryngology. ( 27882651 )
2017
34
Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas. ( 28811626 )
2017
35
Baylisascaris schroederi Infection in Giant Pandas (Ailuropoda melanoleuca) in Foping National Nature Reserve, China. ( 28700323 )
2017
36
Matchmaker.com for pandas. ( 28630711 )
2017
37
Reared-Apart Chinese Twins: Chance Discovery/Twin-Based Research: Twin Study of Media Use; Twin Relations Over the Life Span; Breast-Feeding Opposite-Sex Twins/Print and Online Media: Twins in Fashion; Second Twin Pair Born to Tennis Star; Twin Primes; Twin Pandas. ( 28303775 )
2017
38
Resting site use of giant pandas in Wanglang Nature Reserve. ( 29062136 )
2017
39
Analysis of the breast milk of giant pandas (Ailuropoda melanoleuca) and the preparation of substitutes. ( 26781707 )
2016
40
Long Non-coding RNA, PANDA, Contributes to the Stabilization of p53 Tumor Suppressor Protein. ( 27069137 )
2016
41
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) ( 26866234 )
2016
42
NORMAL VAGINAL BACTERIAL FLORA OF GIANT PANDAS (AILUROPODA MELANOLEUCA) AND THE ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF THE ISOLATES. ( 27468049 )
2016
43
Atmospheric deposition exposes Qinling pandas to toxic pollutants. ( 28039891 )
2016
44
PANDAS: A systematic review of treatment options. ( 27619047 )
2016
45
Role of New Nature Reserve in Assisting Endangered Species Conservation - Case Study of Giant Pandas in the Northern Qionglai Mountains, China. ( 27532870 )
2016
46
Dietary Shifts May Trigger Dysbiosis and Mucous Stools in Giant Pandas (Ailuropoda melanoleuca). ( 27199976 )
2016
47
Decreased microbial diversity and Lactobacillus group in the intestine of geriatric giant pandas (Ailuropoda melanoleuca). ( 27038949 )
2016
48
Complete Genome Sequence of emm4 Streptococcus pyogenes MEW427, a Throat Isolate from a Child Meeting Clinical Criteria for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS). ( 26988046 )
2016
49
Eye care for ageing pandas. ( 27056806 )
2016
50
NORMAL VAGINAL BACTERIAL FLORA OF GIANT PANDAS (AILUROPODA MELANOLEUCA) AND THE ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF THE ISOLATES. ( 27010307 )
2016

Variations for Pandas

Expression for Pandas

Search GEO for disease gene expression data for Pandas.

Pathways for Pandas

GO Terms for Pandas

Sources for Pandas

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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