MCID: PND004
MIFTS: 36

Pandas malady

Neuronal category

Summaries for Pandas

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Panda or Panda bear most often refers to: more...

MalaCards: Pandas, also known as pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, is related to sydenham's chorea and chorea. An important gene associated with Pandas is GJC3 (gap junction protein, gamma 3, 30.2kDa), and among its related pathways are NF-KappaB Family Pathway and Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response. The compounds resiquimod and imiquimod have been mentioned in the context of this disorder. Affiliated tissues include brain.

Aliases & Classifications for Pandas

Sources:
43NIH Rare Diseases, 49Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
pandas:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

pandas 43 49
pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections 43
pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections 49
pediatric autoimmune disorders associated with streptococcus infections 49


Related Diseases for Pandas

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pandas via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 22)
idRelated DiseaseScoreTop Affiliating Genes
1sydenham's chorea10.3
2chorea10.3
3obsessive-compulsive disorder10.2
4n syndrome10.2
5schizophreniform disorder10.1
6wilson disease10.1
7anorexia nervosa10.1
8tic disorder10.1
9blindness10.0CRYAA
10adenocarcinoma10.0HSPE1, UGT1A7, ELF3, ETS2
11breast cancer10.0BAP1, ETS2, ELF3
12rheumatoid arthritis10.0HSPE1, ETS2, ELF3
13rheumatic fever10.0
14conversion disorder10.0
15body dysmorphic disorder10.0
16dirofilariasis10.0
17lyme disease10.0
18legg-calve-perthes disease10.0
19conn's syndrome10.0
20micro syndrome10.0
21hypersomnia10.0
22myoclonus10.0

Graphical network of the top 20 diseases related to Pandas:



Diseases related to pandas

Clinical Features for Pandas

Drugs & Therapeutics for Pandas

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pandas

Drug clinical trials:

Search ClinicalTrials for Pandas

Search NIH Clinical Center for Pandas

Search CenterWatch for Pandas

Genetic Tests for Pandas

Anatomical Context for Pandas

Sources:
33MalaCards
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MalaCards organs/tissues related to Pandas:

33
Brain

Animal Models for Pandas or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Pandas

Sources:
51PubMed
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Articles related to Pandas:

(show top 50)    (show all 154)
idTitleAuthorsYear
1
Analysis of the genetic diversity of the nematode parasite Baylisascaris schroederi from wild giant pandas in different mountain ranges in China. (23924705)
2013
2
Fecal near infrared spectroscopy to discriminate physiological status in giant pandas. (22719982)
2012
3
Supplemental iodine as a key to reproduction in pandas? (22691201)
2012
4
Dental abnormalities in eight captive giant pandas (Ailuropoda melanoleuca) in China. (21906751)
2012
5
Draft genome sequence of Enterobacter cloacae subsp. cloacae strain 08XA1, a fecal bacterium of giant pandas. (23209197)
2012
6
Behavioral and hormonal consequences of transporting giant pandas from China to the United States. (22233212)
2012
7
Important population viability analysis parameters for giant pandas (Aliuropoda melanoleuca). (22653866)
2012
8
Significant genetic boundaries and spatial dynamics of giant pandas occupying fragmented habitat across southwest China. (21251112)
2011
9
Old-growth forest is what giant pandas really need. (21227979)
2011
10
A case of PANDAS treated with tetrabenazine and tonsillectomy. (20207613)
2010
11
Stuttering onset associated with streptococcal infection: a case suggesting stuttering as PANDAS. (21180660)
2010
12
Genetic evidence of recent population contraction in the southernmost population of giant pandas. (21120682)
2010
13
Phenotypic and genotypic characterisation of antimicrobial resistance in faecal bacteria from 30 Giant pandas. (19168331)
2009
14
Chorea-St. Vitus, Sydenham or pandas? (20329434)
2009
15
The PANDAS subgroup of tic disorders and childhood-onset obsessive-compulsive disorder. (19913659)
2009
16
Executive and attention functioning among children in the PANDAS subgroup. (18622810)
2009
17
Challenges in the identification and treatment of PANDAS: a case series. (18499734)
2009
18
Vocal discrimination of potential mates by female giant pandas (Ailuropoda melanoleuca). (19535366)
2009
19
The PANDAS syndrome. (19280860)
2009
20
Taiwan, China and the WHO: of pandas and pandemics. (19342431)
2009
21
Antineuronal antibodies in OCD: comparisons in children with OCD-only, OCD+chronic tics and OCD+PANDAS. (19628285)
2009
22
Delayed implantation in giant pandas: the first comprehensive empirical evidence. (19692498)
2009
23
Isolation and identification of a canine coronavirus strain from giant pandas (Ailuropoda melanoleuca). (19687628)
2009
24
Vocal cues to identity and relatedness in giant pandas (Ailuropoda melanoleuca). (19894848)
2009
25
Potential chemosignals in the anogenital gland secretion of giant pandas, Ailuropoda melanoleuca, associated with sex and individual identity. (18293041)
2008
26
Distribution of economic benefits from ecotourism: a case study of Wolong Nature Reserve For Giant Pandas in China. (18853224)
2008
27
Chain reaction or time bomb: a neuropsychiatric-developmental/neurodevelopmental formulation of tourettisms, pervasive developmental disorder, and schizophreniform symptomatology associated with PANDAS. (17654411)
2007
28
PANDAS: overview of the hypothesis. (16536362)
2006
29
PANDAS (Paediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection). (16892924)
2006
30
Cognitive-behavioral therapy for PANDAS-related obsessive-compulsive disorder: findings from a preliminary waitlist controlled open trial. (17003662)
2006
31
Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls. (16207842)
2005
32
Lions, tigers, and pandas, oh my. (15955882)
2005
33
PANDAS with catatonia: a case report. Therapeutic response to lorazepam and plasmapheresis. (16239863)
2005
34
Antibasal ganglia antibodies and PANDAS. (15382207)
2005
35
Behavioral treatment of a child with PANDAS. (15100555)
2004
36
Music, pandas, and muggers: on the affective psychology of value. (14979749)
2004
37
Chemical cues identify gender and individuality in Giant pandas (Ailuropoda melanoleuca). (12918929)
2003
38
Antistreptolysin-O titers: implications for adult PANDAS. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. (11823288)
2002
39
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). (12142939)
2002
40
PANDAS variant and body dysmorphic disorder. (11384911)
2001
41
The pandas' habitat at Wolong Nature Reserve. (11476086)
2001
42
Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). (11466169)
2001
43
The effects of sex, reproductive condition and context on discrimination of conspecific odours by giant pandas. (10973725)
2000
44
Giant pandas discriminate individual differences in conspecific scent. (10328790)
1999
45
PANDAS and immunomodulatory therapy. (10513701)
1999
46
Is Tourette's syndrome one of the PANDAS? (10088120)
1999
47
Pediatric autoimmune neuropsychiatric disorders associated with streptococci (PANDAS). (10093955)
1999
48
Cytoplasmic creatine kinases from giant pandas. (9442924)
1997
49
Ursodeoxycholic acid in the Ursidae: biliary bile acids of bears, pandas, and related carnivores. (8263415)
1993
50
Canine distemper virus infection in lesser pandas (Ailurus fulgens). (2601238)
1989

Genetic Variations for Pandas

Expression for genes affiliated with Pandas

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pandas

Search GEO for disease gene expression data for Pandas.

Pathways for genes affiliated with Pandas

Sources:
52QIAGEN, 12EMD Millipore, 4Cell Signaling Technology, 53R&D Systems, 60Tocris Bioscience, 54Reactome, 38NCBI BioSystems Database
See all sources

Pathways related to Pandas according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5TLR7, TLR1, TLR8, CSNK2A2
210.5TLR8, TLR1, TLR7
310.5TLR8, TLR1, TLR7
410.5TLR8, TLR1, TLR7
5
Hide members
10.5TLR8, TLR1, TLR7
610.5TLR8, TLR1, TLR7
710.5TLR8, TLR1, TLR7
8
Hide members
10.5TLR8, TLR1, TLR7
9
Hide members
10.5TLR7, TLR1, TLR8
10
Hide members
10.5TLR7, TLR1, TLR8
11
Hide members
10.5TLR7, TLR1, TLR8
1210.5TLR7, TLR8
13
Hide members
10.5TLR8, TLR7

Compounds for genes affiliated with Pandas

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Pandas according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1resiquimod45 6011.8TLR8, TLR1, TLR7
2imiquimod45 29 60 1113.8TLR8, TLR1, TLR7
3r8482910.8TLR8, TLR7
4imidazoquinoline4510.8TLR7, TLR8
5poly(i:c)6010.7TLR1, TLR7
6pam3csk46010.7TLR1, TLR7
7pam2csk46010.7TLR1, TLR7
8peptidoglycan45 2911.7TLR7, TLR1, ATN1
9estradiol45 11 2412.7FSHB, CYP2A13, UGT1A7, CSNK2A2
10carbenoxolone disodium6010.6GJB6, GJC3
11gap 276010.6GJB6, GJC3
12scrambled 10panx6010.6GJC3, GJB6
13cotinine45 2411.5CYP2A13, UGT1A7
1410panx6010.5GJC3, GJB6
15orthophosphate4510.4CSNK2A2, UGT1A7
16octanol29 2411.2GJB6, GJC3

GO Terms for genes affiliated with Pandas

Sources:
16Gene Ontology
See all sources

Cellular components related to Pandas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1connexon complexGO:00592210.5GJB6, GJC3
2endolysosome membraneGO:03602010.4TLR8, TLR7
3endoplasmic reticulum membraneGO:00578910.2EI24, CYP2A13, UGT1A7, TLR8, TLR7

Biological processes related to Pandas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-alpha biosynthetic processGO:04535610.6TLR8, TLR7
2inflammatory responseGO:00695410.5ELF3, TLR8, TLR1, TLR7
3positive regulation of interferon-beta biosynthetic processGO:04535910.5TLR8, TLR7
4positive regulation of interleukin-8 biosynthetic processGO:04541610.4TLR8, TLR7
5positive regulation of interferon-gamma biosynthetic processGO:04507810.2TLR7, TLR8

Molecular functions related to Pandas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single-stranded RNA bindingGO:00372710.5TLR8, TLR7

Products for genes affiliated with Pandas

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pandas

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet