MCID: PND004
MIFTS: 35

Pandas malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Pandas

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Pandas, Aliases & Descriptions:

Name: Pandas 41 47
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections 41
 
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections 47
Pediatric Autoimmune Disorders Associated with Streptococcus Infections 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
pandas:
Inheritance: Not applicable; Age of onset: Childhood


External Ids:

Orphanet47 66624

Summaries for Pandas

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Wikipedia:63 Panda or Panda bear most often refers to: more...

MalaCards based summary: Pandas, also known as pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, is related to sydenham's chorea and neuroectodermal tumor. An important gene associated with Pandas is FSHB (follicle stimulating hormone, beta polypeptide), and among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and CFTR translational fidelity class I mutations . The compounds mibg and spec-t have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and skin.

Related Diseases for Pandas

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Graphical network of the top 20 diseases related to Pandas:



Diseases related to pandas

Symptoms for Pandas

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Drugs & Therapeutics for Pandas

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Drug clinical trials:

Search ClinicalTrials for Pandas

Search NIH Clinical Center for Pandas

Genetic Tests for Pandas

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Anatomical Context for Pandas

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MalaCards organs/tissues related to Pandas:

31
Bone, Brain, Skin

Animal Models for Pandas or affiliated genes

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Publications for Pandas

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Articles related to Pandas:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
The primary structure of COMT gene is not involved in the diet shift of the giant or the red pandas. (25748822)
2015
2
Endangered species. Captive pandas succumb to killer virus. (25678636)
2015
3
Disordered Eating and Food Restrictions in Children with PANDAS/PANS. (25329522)
2014
4
Sydenham Chorea and PANDAS in South Africa: Review of Evidence and Recommendations for Management in Resource-Poor Countries. (25227516)
2014
5
A link between perianal strep and pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS). (24763762)
2014
6
A 'combined framework' approach to developing a patient decision aid: the PANDAs model. (25341370)
2014
7
A case of PANDAS with Kleine-Levin type periodic hypersomnia. (22261244)
2012
8
Clinical effectiveness of a patient decision aid to improve decision quality and glycaemic control in people with diabetes making treatment choices: a cluster randomised controlled trial (PANDAs) in general practice. (23129571)
2012
9
Fecal near infrared spectroscopy to discriminate physiological status in giant pandas. (22719982)
2012
10
Supplemental iodine as a key to reproduction in pandas? (22691201)
2012
11
Dental abnormalities in eight captive giant pandas (Ailuropoda melanoleuca) in China. (21906751)
2012
12
Significant genetic boundaries and spatial dynamics of giant pandas occupying fragmented habitat across southwest China. (21251112)
2011
13
Old-growth forest is what giant pandas really need. (21227979)
2011
14
Conservation implications of drastic reductions in the smallest and most isolated populations of giant pandas. (20408868)
2010
15
Serosurvey of selected viruses in captive giant pandas (Ailuropoda melanoleuca) in China. (19913371)
2010
16
Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study. (19152896)
2009
17
Phenotypic and genotypic characterisation of antimicrobial resistance in faecal bacteria from 30 Giant pandas. (19168331)
2009
18
Serum autoantibodies measured by immunofluorescence confirm a failure to differentiate PANDAS and Tourette syndrome from controls. (18823914)
2009
19
Chorea-St. Vitus, Sydenham or pandas? (20329434)
2009
20
The PANDAS subgroup of tic disorders and childhood-onset obsessive-compulsive disorder. (19913659)
2009
21
Potential chemosignals in the anogenital gland secretion of giant pandas, Ailuropoda melanoleuca, associated with sex and individual identity. (18293041)
2008
22
'Face of the giant panda' sign in Wilson disease. (18839167)
2008
23
PANDAS and paroxysms: a case of conversion disorder? (18294094)
2008
24
What every psychiatrist should know about PANDAS: a review. (18495013)
2008
25
PANDAS in siblings: a common risk? (17539928)
2007
26
Nucleotide sequence of cDNA encoding the mitochondrial precursor protein of the ATPase inhibitor from the giant panda (Ailuropoda melanoleuca). (17822358)
2007
27
Autoimmune neuropsychiatric disorders associated with streptococcal infection: Sydenham chorea, PANDAS, and PANDAS variants. (16970875)
2006
28
How do giant pandas (Ailuropoda melanoleuca) respond to varying properties of enrichments? A comparison of behavioral profiles among five enrichment items. (16131261)
2005
29
Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls. (16207842)
2005
30
Lions, tigers, and pandas, oh my. (15955882)
2005
31
Atrial natriuretic peptide induces an acrosome reaction in giant panda spermatozoa and enhances their penetration of salt-stored porcine oocytes. (16139606)
2005
32
Distinguishing PANDAS from Sydenham's chorea: case report and review of the literature. (15261885)
2004
33
The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) etiology for tics and obsessive-compulsive symptoms: hypothesis or entity? Practical considerations for the clinician. (15060240)
2004
34
Echocardiographic findings in the PANDAS subgroup. (15545618)
2004
35
Behavioral and developmental consequences of early rearing experience for captive giant pandas (Ailuropoda melanoleuca). (14498799)
2003
36
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). (11791105)
2002
37
Late-onset PANDAS syndrome with abdominal muscle involvement. (12138313)
2002
38
Two cases of ADHD following GABHS infection: a PANDAS subgroup? (12410069)
2002
39
Hyperostotic bone disease in red pandas (Ailurus fulgens). (12462494)
2002
40
Antistreptolysin-O titers: implications for adult PANDAS. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. (11823288)
2002
41
Prospective identification and treatment of children with pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS). (11929370)
2002
42
Avascular necrosis of the femoral heads in a red panda (Ailurus fulgens fulgens): possible Legg-Calve-Perthes disease. (12462497)
2002
43
Ecological degradation in protected areas: the case of Wolong Nature Reserve for giant pandas. (11292872)
2001
44
Ecology. Giant pandas in a changing landscape. (11711657)
2001
45
Giant pandas discriminate individual differences in conspecific scent. (10328790)
1999
46
Dermatophytosis in red pandas (Ailurus fulgens fulgens): a review of 14 cases. (10749446)
1999
47
PANDAS: the search for environmental triggers of pediatric neuropsychiatric disorders. Lessons from rheumatic fever. (9733286)
1998
48
Acute myoclonus secondary to group A beta-hemolytic streptococcus infection: A PANDAS variant. (9796759)
1998
49
IVF project stirs debate over how to preserve pandas. (8658127)
1996
50
Canine distemper virus infection in lesser pandas (Ailurus fulgens). (2601238)
1989

Variations for Pandas

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Expression for genes affiliated with Pandas

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Search GEO for disease gene expression data for Pandas.

Pathways for genes affiliated with Pandas

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Pathways related to Pandas according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6RPS19, RPS25
2
Show member pathways
Cytoplasmic Ribosomal Proteins36
9.1RPLP1, RPS19, RPS25
3
Show member pathways
9.1RPLP1, RPS19, RPS25
4
Show member pathways
8.8FSHB, RPS25, RPS19, RPLP1
5
Show member pathways
8.6NPPA, RPLP1, RPS19, RPS25
68.6RPS25, RPS19, RPLP1, NPPA

Compounds for genes affiliated with Pandas

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Compounds related to Pandas according to GeneCards Suite gene sharing:

(show all 16)
idCompoundScoreTop Affiliating Genes
1mibg439.6NPPA, ENO2
2spec-t439.6NPPA, ENO2
3propofol43 49 1211.5ENO2, NPPA
45-hydroxyindoleacetic acid43 2410.2ENO2, CEACAM3
5sialic acid439.0FSHB, CEACAM3, ENO2
6hematoxylin438.9ENO2, CEACAM3
7steroid438.9FSHB, CEACAM3, CSNK2A2, CRYAB
8dopamine43 28 24 1211.8CSNK2A2, ENO2, NPPA
9paraffin438.7ENO2, CRYAB, CEACAM3
10thymidine43 249.6CEACAM3, CSNK2A2, CRYAB, ENO2
11acth438.6NPPA, ENO2, CEACAM3, FSHB
12creatinine438.6NPPA, ENO2, CEACAM3
13aspartate438.6ENO2, CRYAB, CSNK2A2, CEACAM3
14progesterone43 28 59 24 1212.4FSHB, CEACAM3, CSNK2A2, CRYAB, ENO2
15estrogen438.3NPPA, ENO2, CSNK2A2, CEACAM3, FSHB
16calcium43 49 24 1210.9FSHB, CEACAM3, CSNK2A2, CRYAB, ENO2, NPPA

GO Terms for genes affiliated with Pandas

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Cellular components related to Pandas according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ribosomeGO:00058409.6RPS19, RPS25
2cytosolic small ribosomal subunitGO:00226279.3RPS19, RPS25
3cytosolGO:00058297.7ENO2, RPS25, RPS19, RPLP1, CSNK2A2, CRYAB

Biological processes related to Pandas according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1ribosomal small subunit assemblyGO:00000289.9RPS19, RPS25
2female pregnancyGO:00075659.8NPPA, FSHB
3viral transcriptionGO:00190839.3RPLP1, RPS19, RPS25
4translational terminationGO:00064159.3RPLP1, RPS19, RPS25
5translational elongationGO:00064149.3RPS25, RPS19, RPLP1
6SRP-dependent cotranslational protein targeting to membraneGO:00066149.3RPLP1, RPS19, RPS25
7viral life cycleGO:00190589.3RPS25, RPS19, RPLP1
8nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:00001849.2RPLP1, RPS19, RPS25
9translational initiationGO:00064139.2RPS25, RPS19, RPLP1
10mRNA metabolic processGO:00160719.1RPS25, RPS19, RPLP1
11RNA metabolic processGO:00160709.0RPLP1, RPS19, RPS25
12cellular protein metabolic processGO:00442678.9RPLP1, RPS19, RPS25, FSHB
13translationGO:00064128.8RPLP1, RPS19, RPS25
14gene expressionGO:00104678.7RPS25, RPS19, RPLP1, NPPA

Molecular functions related to Pandas according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.8NPPA, FSHB
2structural constituent of ribosomeGO:00037358.8RPLP1, RPS19, RPS25

Products for genes affiliated with Pandas

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  • Antibodies
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Sources for Pandas

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet