MCID: PND004
MIFTS: 31

Pandas malady

Neuronal diseases category

Summaries for Pandas

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Panda or Panda bear most often refers to: more...

MalaCards: Pandas, also known as pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, is related to obsessive-compulsive disorder and tic disorder. An important gene associated with Pandas is GJC3 (gap junction protein, gamma 3, 30.2kDa), and among its related pathways are NF-KappaB Family Pathway and Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response. The compounds resiquimod and imiquimod have been mentioned in the context of this disorder.

Aliases & Classifications for Pandas

About this section
Sources:
42NIH Rare Diseases, 48Orphanet, 57SNOMED-CT via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
pandas:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

pandas 42 48
pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections 42
pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections 48
pediatric autoimmune disorders associated with streptococcus infections 48


External Ids:

SNOMED-CT via Orphanet57 446682003

Related Diseases for Pandas

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Pandas:



Diseases related to pandas

Clinical Features for Pandas

About this section

Drugs & Therapeutics for Pandas

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Pandas

Drug clinical trials:

Search ClinicalTrials for Pandas

Search NIH Clinical Center for Pandas

Search CenterWatch for Pandas

Genetic Tests for Pandas

About this section

Anatomical Context for Pandas

About this section

Animal Models for Pandas or affiliated genes

About this section

Publications for Pandas

About this section

Genetic Variations for Pandas

About this section

Expression for genes affiliated with Pandas

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pandas

Search GEO for disease gene expression data for Pandas.

Pathways for genes affiliated with Pandas

About this section
Sources:
51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology, 52R&D Systems, 59Tocris Bioscience, 53Reactome, 37NCBI BioSystems Database
See all sources

Pathways related to Pandas according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5TLR7, TLR1, TLR8, CSNK2A2
210.5TLR8, TLR1, TLR7
310.5TLR8, TLR1, TLR7
410.5TLR8, TLR1, TLR7
5
Hide members
10.5TLR8, TLR1, TLR7
610.5TLR8, TLR1, TLR7
710.5TLR8, TLR1, TLR7
8
Hide members
10.5TLR8, TLR1, TLR7
9
Hide members
10.5TLR7, TLR1, TLR8
10
Hide members
10.5TLR7, TLR1, TLR8
11
Hide members
10.5TLR7, TLR1, TLR8
1210.5TLR7, TLR8
13
Hide members
10.5TLR8, TLR7

Compounds for genes affiliated with Pandas

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Pandas according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1resiquimod44 5911.8TLR8, TLR1, TLR7
2imiquimod44 28 59 1113.8TLR8, TLR1, TLR7
3r8482810.8TLR8, TLR7
4imidazoquinoline4410.8TLR7, TLR8
5poly(i:c)5910.7TLR1, TLR7
6pam3csk45910.7TLR1, TLR7
7pam2csk45910.7TLR1, TLR7
8peptidoglycan44 2811.7TLR7, TLR1, ATN1
9estradiol44 11 2412.7FSHB, CYP2A13, UGT1A7, CSNK2A2
10carbenoxolone disodium5910.6GJB6, GJC3
11gap 275910.6GJB6, GJC3
12scrambled 10panx5910.6GJC3, GJB6
13cotinine44 2411.5CYP2A13, UGT1A7
1410panx5910.5GJC3, GJB6
15orthophosphate4410.4CSNK2A2, UGT1A7
16octanol28 2411.2GJB6, GJC3

GO Terms for genes affiliated with Pandas

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pandas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1connexon complexGO:00592210.5GJB6, GJC3
2endolysosome membraneGO:03602010.4TLR8, TLR7
3endoplasmic reticulum membraneGO:00578910.2EI24, CYP2A13, UGT1A7, TLR8, TLR7

Biological processes related to Pandas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-alpha biosynthetic processGO:04535610.6TLR8, TLR7
2inflammatory responseGO:00695410.5ELF3, TLR8, TLR1, TLR7
3positive regulation of interferon-beta biosynthetic processGO:04535910.5TLR8, TLR7
4positive regulation of interleukin-8 biosynthetic processGO:04541610.4TLR8, TLR7
5positive regulation of interferon-gamma biosynthetic processGO:04507810.2TLR7, TLR8

Molecular functions related to Pandas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single-stranded RNA bindingGO:00372710.5TLR8, TLR7

Products for genes affiliated with Pandas

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pandas

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet