MCID: PND004
MIFTS: 40

Pandas malady

Rare diseases, Neuronal diseases categories
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Summaries for Pandas

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Panda or Panda bear most often refers to: more...

MalaCards: Pandas, also known as pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, is related to chorea and obsessive-compulsive disorder. An important gene associated with Pandas is FSHB (follicle stimulating hormone, beta polypeptide), and among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and CFTR translational fidelity class I mutations . The compounds mibg and spec-t have been mentioned in the context of this disorder. Affiliated tissues include bone and brain.

Aliases & Classifications for Pandas

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Sources:
43NIH Rare Diseases, 49Orphanet, 59SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
pandas:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

pandas 43 49
pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections 43
pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections 49
pediatric autoimmune disorders associated with streptococcus infections 49


External Ids:

SNOMED-CT via Orphanet59 446682003

Related Diseases for Pandas

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pandas:



Diseases related to pandas

Symptoms for Pandas

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Drugs & Therapeutics for Pandas

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pandas

Search NIH Clinical Center for Pandas

Genetic Tests for Pandas

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Anatomical Context for Pandas

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Sources:
33MalaCards
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MalaCards organs/tissues related to Pandas:

33
Bone, Brain

Animal Models for Pandas or affiliated genes

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Publications for Pandas

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Sources:
52PubMed
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Articles related to Pandas:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation. (23242367)
2013
2
A case of PANDAS with Kleine-Levin type periodic hypersomnia. (22261244)
2012
3
Clinical effectiveness of a patient decision aid to improve decision quality and glycaemic control in people with diabetes making treatment choices: a cluster randomised controlled trial (PANDAs) in general practice. (23129571)
2012
4
Fecal near infrared spectroscopy to discriminate physiological status in giant pandas. (22719982)
2012
5
Dental abnormalities in eight captive giant pandas (Ailuropoda melanoleuca) in China. (21906751)
2012
6
Lyme disease and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS): an overview. (22393303)
2012
7
Significant genetic boundaries and spatial dynamics of giant pandas occupying fragmented habitat across southwest China. (21251112)
2011
8
Old-growth forest is what giant pandas really need. (21227979)
2011
9
Conservation implications of drastic reductions in the smallest and most isolated populations of giant pandas. (20408868)
2010
10
Serosurvey of selected viruses in captive giant pandas (Ailuropoda melanoleuca) in China. (19913371)
2010
11
Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study. (19152896)
2009
12
Phenotypic and genotypic characterisation of antimicrobial resistance in faecal bacteria from 30 Giant pandas. (19168331)
2009
13
Serum autoantibodies measured by immunofluorescence confirm a failure to differentiate PANDAS and Tourette syndrome from controls. (18823914)
2009
14
Chorea-St. Vitus, Sydenham or pandas? (20329434)
2009
15
The PANDAS subgroup of tic disorders and childhood-onset obsessive-compulsive disorder. (19913659)
2009
16
Potential chemosignals in the anogenital gland secretion of giant pandas, Ailuropoda melanoleuca, associated with sex and individual identity. (18293041)
2008
17
'Face of the giant panda' sign in Wilson disease. (18839167)
2008
18
PANDAS and paroxysms: a case of conversion disorder? (18294094)
2008
19
What every psychiatrist should know about PANDAS: a review. (18495013)
2008
20
PANDAS in siblings: a common risk? (17539928)
2007
21
Nucleotide sequence of cDNA encoding the mitochondrial precursor protein of the ATPase inhibitor from the giant panda (Ailuropoda melanoleuca). (17822358)
2007
22
Certain eating disorders may be a neuropsychiatric manifestation of PANDAS: case report. (18421369)
2007
23
Autoimmune neuropsychiatric disorders associated with streptococcal infection: Sydenham chorea, PANDAS, and PANDAS variants. (16970875)
2006
24
Implications of the functional anatomy of the hand and forearm of Ailurus fulgens (Carnivora, Ailuridae) for the evolution of the 'false-thumb' in pandas. (17118063)
2006
25
How do giant pandas (Ailuropoda melanoleuca) respond to varying properties of enrichments? A comparison of behavioral profiles among five enrichment items. (16131261)
2005
26
Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls. (16207842)
2005
27
Lions, tigers, and pandas, oh my. (15955882)
2005
28
Atrial natriuretic peptide induces an acrosome reaction in giant panda spermatozoa and enhances their penetration of salt-stored porcine oocytes. (16139606)
2005
29
Distinguishing PANDAS from Sydenham's chorea: case report and review of the literature. (15261885)
2004
30
The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) etiology for tics and obsessive-compulsive symptoms: hypothesis or entity? Practical considerations for the clinician. (15060240)
2004
31
Echocardiographic findings in the PANDAS subgroup. (15545618)
2004
32
Chemical cues identify gender and individuality in Giant pandas (Ailuropoda melanoleuca). (12918929)
2003
33
Behavioral and developmental consequences of early rearing experience for captive giant pandas (Ailuropoda melanoleuca). (14498799)
2003
34
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). (11791105)
2002
35
Late-onset PANDAS syndrome with abdominal muscle involvement. (12138313)
2002
36
Two cases of ADHD following GABHS infection: a PANDAS subgroup? (12410069)
2002
37
Hyperostotic bone disease in red pandas (Ailurus fulgens). (12462494)
2002
38
Antistreptolysin-O titers: implications for adult PANDAS. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. (11823288)
2002
39
Prospective identification and treatment of children with pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS). (11929370)
2002
40
Avascular necrosis of the femoral heads in a red panda (Ailurus fulgens fulgens): possible Legg-Calve-Perthes disease. (12462497)
2002
41
Ecological degradation in protected areas: the case of Wolong Nature Reserve for giant pandas. (11292872)
2001
42
Ecology. Giant pandas in a changing landscape. (11711657)
2001
43
Giant pandas discriminate individual differences in conspecific scent. (10328790)
1999
44
Dermatophytosis in red pandas (Ailurus fulgens fulgens): a review of 14 cases. (10749446)
1999
45
PANDAS: the search for environmental triggers of pediatric neuropsychiatric disorders. Lessons from rheumatic fever. (9733286)
1998
46
Acute myoclonus secondary to group A beta-hemolytic streptococcus infection: A PANDAS variant. (9796759)
1998
47
IVF project stirs debate over how to preserve pandas. (8658127)
1996
48
Canine distemper virus infection in lesser pandas (Ailurus fulgens). (2601238)
1989
49
Conservationists in Panda-monium: U.S zoos and conservationists tangle over the propriety of borrowing pandas--an endangered species--and exploiting them in highly lucrative exhibits. (17774572)
1988
50
Distemper infection in lesser pandas due to administration of a canine distemper live vaccine. (574575)
1979

Variations for Pandas

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Expression for genes affiliated with Pandas

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pandas

Search GEO for disease gene expression data for Pandas.

Pathways for genes affiliated with Pandas

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Sources:
50PathCards, 55Reactome, 60Thomson Reuters, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Pandas according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6RPS19, RPS25
2
Show member pathways
Cytoplasmic Ribosomal Proteins38
9.1RPLP1, RPS19, RPS25
3
Show member pathways
9.1RPLP1, RPS19, RPS25
4
Show member pathways
8.8FSHB, RPS25, RPS19, RPLP1
5
Show member pathways
8.6NPPA, RPLP1, RPS19, RPS25
68.6RPS25, RPS19, RPLP1, NPPA

Compounds for genes affiliated with Pandas

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Pandas according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1mibg459.6NPPA, ENO2
2spec-t459.6NPPA, ENO2
3propofol45 51 1111.5ENO2, NPPA
45-hydroxyindoleacetic acid45 2410.2ENO2, CEACAM3
5sialic acid459.0FSHB, CEACAM3, ENO2
6hematoxylin458.9ENO2, CEACAM3
7steroid458.9FSHB, CEACAM3, CSNK2A2, CRYAB
8dopamine45 29 24 1111.8CSNK2A2, ENO2, NPPA
9paraffin458.7ENO2, CRYAB, CEACAM3
10thymidine45 249.6CEACAM3, CSNK2A2, CRYAB, ENO2
11acth458.6NPPA, ENO2, CEACAM3, FSHB
12creatinine458.6NPPA, ENO2, CEACAM3
13aspartate458.6ENO2, CRYAB, CSNK2A2, CEACAM3
14progesterone45 29 61 24 1112.4FSHB, CEACAM3, CSNK2A2, CRYAB, ENO2
15estrogen458.3NPPA, ENO2, CSNK2A2, CEACAM3, FSHB
16calcium45 51 24 1110.9FSHB, CEACAM3, CSNK2A2, CRYAB, ENO2, NPPA

GO Terms for genes affiliated with Pandas

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16Gene Ontology
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Cellular components related to Pandas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ribosomeGO:0058409.6RPS19, RPS25
2cytosolic small ribosomal subunitGO:0226279.3RPS19, RPS25
3cytosolGO:0058297.7ENO2, RPS25, RPS19, RPLP1, CSNK2A2, CRYAB

Biological processes related to Pandas according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1ribosomal small subunit assemblyGO:0000289.9RPS19, RPS25
2female pregnancyGO:0075659.8NPPA, FSHB
3viral transcriptionGO:0190839.3RPLP1, RPS19, RPS25
4translational terminationGO:0064159.3RPLP1, RPS19, RPS25
5translational elongationGO:0064149.3RPS25, RPS19, RPLP1
6SRP-dependent cotranslational protein targeting to membraneGO:0066149.3RPLP1, RPS19, RPS25
7viral life cycleGO:0190589.3RPS25, RPS19, RPLP1
8nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:0001849.2RPLP1, RPS19, RPS25
9translational initiationGO:0064139.2RPS25, RPS19, RPLP1
10mRNA metabolic processGO:0160719.1RPS25, RPS19, RPLP1
11RNA metabolic processGO:0160709.0RPLP1, RPS19, RPS25
12cellular protein metabolic processGO:0442678.9RPLP1, RPS19, RPS25, FSHB
13translationGO:0064128.8RPLP1, RPS19, RPS25
14gene expressionGO:0104678.7RPS25, RPS19, RPLP1, NPPA

Molecular functions related to Pandas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.8NPPA, FSHB
2structural constituent of ribosomeGO:0037358.8RPLP1, RPS19, RPS25

Products for genes affiliated with Pandas

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pandas

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet