MCID: PND004
MIFTS: 29

Pandas malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Pandas

Aliases & Descriptions for Pandas:

Name: Pandas 50 56
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections 50 56
Pediatric Autoimmune Disorders Associated with Streptococcus Infections 50 56
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections 50
Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus 50

Characteristics:

Orphanet epidemiological data:

56
pandas
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA66624

Summaries for Pandas

NIH Rare Diseases : 50 pandas is an acronym for pediatric autoimmune neuropsychiatric disorder associated with streptococcus. it is used to describe a condition in children whose symptoms of obsessive-compulsive disorder (ocd) or a tic disorder (i.e. tourette syndrome) are worsened by group a streptococcal (gas) infections. the underlying cause of pandas is unclear, but studies suggest that a strep infection causes an abnormal immune response resulting in neuropsychiatric symptoms. the association between pandas and gas is controversial because the cause has not been proven. management is centered on providing antibiotics for gas infection, and medication or behavioral therapy for neuropsychiatric symptoms. last updated: 7/5/2016

MalaCards based summary : Pandas, also known as pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections, is related to attention deficit-hyperactivity disorder and sydenham chorea. An important gene associated with Pandas is ENO2 (Enolase 2). The drugs Chlorhexidine and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and eye.

Related Diseases for Pandas

Diseases related to Pandas via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
id Related Disease Score Top Affiliating Genes
1 attention deficit-hyperactivity disorder 10.0
2 sydenham chorea 9.9
3 vaginitis 9.8
4 obsessive-compulsive disorder 9.8
5 anorexia nervosa 9.8
6 wilson disease 9.8
7 pervasive developmental disorder 9.8
8 obesity 9.6
9 dermatitis 9.6
10 tic disorder 9.6
11 avascular necrosis of the femoral head 9.6
12 gastric dilatation 9.6
13 legg-calve-perthes disease 9.6
14 pancreatitis 9.6
15 neuronitis 9.6
16 influenza 9.6
17 eating disorder 9.6
18 dermatophytosis 9.6
19 body dysmorphic disorder 9.6
20 hypersomnia 9.6
21 stuttering 9.6
22 myoclonus 9.6
23 dirofilariasis 9.6
24 lyme disease 9.6
25 dementia 9.6
26 rheumatic fever 9.6
27 conversion disorder 9.6

Graphical network of the top 20 diseases related to Pandas:



Diseases related to Pandas

Symptoms & Phenotypes for Pandas

Drugs & Therapeutics for Pandas

Drugs for Pandas (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 101)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
2
Everolimus Approved Phase 4 159351-69-6 6442177
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
5
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
6
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
7
Ibuprofen Approved Phase 4 15687-27-1 3672
8
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
9 Anti-Bacterial Agents Phase 4,Phase 2
10 Antibiotics, Antitubercular Phase 4,Phase 2
11 Anti-Infective Agents Phase 4,Phase 2
12 Peripheral Nervous System Agents Phase 4,Phase 3
13 Antifungal Agents Phase 4
14 Anti-Infective Agents, Local Phase 4
15 Chlorhexidine gluconate Phase 4
16 Dermatologic Agents Phase 4
17 Disinfectants Phase 4
18 Immunosuppressive Agents Phase 4,Phase 2
19 Analgesics Phase 4,Phase 3
20 Analgesics, Non-Narcotic Phase 4,Phase 3
21 Anti-Inflammatory Agents Phase 4
22 Anti-Inflammatory Agents, Non-Steroidal Phase 4
23 Antirheumatic Agents Phase 4
24 Cyclooxygenase 2 Inhibitors Phase 4
25 Cyclooxygenase Inhibitors Phase 4
26
Goserelin Approved Phase 3 65807-02-5 47725 5311128
27
Eslicarbazepine acetate Approved Phase 3 75970-99-9, 236395-14-5 123618
28
Pantoprazole Approved Phase 3 102625-70-7 4679
29
Dexmedetomidine Approved, Vet_approved Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
30
Remifentanil Approved Phase 3 132875-61-7 60815
31
Sevoflurane Approved, Vet_approved Phase 3 28523-86-6 5206
32 Neurotransmitter Agents Phase 3,Phase 2
33 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2
34
Serotonin Phase 3,Phase 2 50-67-9 5202
35 Serotonin Agents Phase 3,Phase 2
36 Serotonin Uptake Inhibitors Phase 3,Phase 2
37 Antibodies Phase 3,Phase 2
38 gamma-Globulins Phase 3,Phase 2
39 Immunoglobulins Phase 3,Phase 2
40 Immunoglobulins, Intravenous Phase 3,Phase 2
41 Rho(D) Immune Globulin Phase 3,Phase 2
42 Adrenergic Agents Phase 3
43 Adrenergic Agonists Phase 3
44 Autonomic Agents Phase 3
45 Androgens Phase 3
46 Antineoplastic Agents, Hormonal Phase 3
47 Anticonvulsants Phase 3
48 Diuretics, Potassium Sparing Phase 3
49 Sodium Channel Blockers Phase 3
50 Anesthetics Phase 3

Interventional clinical trials:

(show all 39)
id Name Status NCT ID Phase
1 Comparison of BuMA eG Based BioDegradable Polymer Stent With EXCEL Biodegradable Polymer Sirolimus-eluting Stent in "Real-World" Practice Completed NCT02017275 Phase 4
2 Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections Completed NCT00001658 Phase 4
3 Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen Completed NCT00346216 Phase 4
4 One Month Degarelix/Comparator Treatment for Prostate Cancer in Chinese Population Completed NCT01744366 Phase 3
5 Safety and Efficacy of Eslicarbazepine Acetate Monotherapy in Subjects With Partial Epilepsy Not Well Controlled by Current Antiepileptic Drugs Completed NCT00866775 Phase 3
6 Eslicarbazepine Acetate Monotherapy Long Term Study Completed NCT00910247 Phase 3
7 A Trial of Two Fixed Doses of ZX008 (Fenfluramine HCl) in Children and Young Adults With Dravet Syndrome Recruiting NCT02682927 Phase 3
8 Intravenous Immunoglobulin for PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections) Active, not recruiting NCT01281969 Phase 3
9 An Open-Label Extension Trial to Assess the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride HCl) Oral Solution in Children and Young Adults With Dravet Syndrome Enrolling by invitation NCT02823145 Phase 3
10 A Study to Compare the Long-term Outcomes After Two Different Anaesthetics Not yet recruiting NCT03089905 Phase 3
11 Clinical Study, Multicenter, Randomized With 2 Arms of Pantoprazole + Domperidone and Pantoprazole Isolated at the Gastroesophageal Reflux Disease Withdrawn NCT01710462 Phase 3
12 Management of Eczema by Specific Probiotic Strains Withdrawn NCT01230190 Phase 3
13 Antibiotic Treatment and Intravenous Immunoglobulin Trial for PANDAS Unknown status NCT01769027 Phase 2
14 Antibiotic Treatment Trial for the PANDAS/PANS Phenotype Completed NCT01617083 Phase 2
15 Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup) Completed NCT00001359 Phase 2
16 The Alberta Diet: Effectiveness Study Completed NCT01625507 Phase 2
17 Study of I Line FOLFOX + Panitumumab vs 5FU + Panitumumab in RAS and BRAF WT Metastatic Colorectal Cancer Elderly Patients Recruiting NCT02904031 Phase 2
18 Neoadjuvant mFolfirinox With or Without Preoperative Concomitant Chemoradiotherapy in Patients With Borderline Resectable Pancreatic Carcinoma (PANDAS-PRODIGE 44) Recruiting NCT02676349 Phase 2
19 A Parp Inhibitor (BMN 673) for Inoperable Advanced eNDometrial cAncer Withdrawn NCT02127151 Phase 2
20 Prospective Assessment in Newborns for Diabetes Autoimmunity Unknown status NCT00649246
21 Prognostic Accuracy of Coronary CT and Dobutamine Stress Echocardiography in Patient Undergoing Non-cardiac Surgery Unknown status NCT02250963
22 Panda: Evaluation of a Smartphone-based Perioperative Pain Assessment Tool Completed NCT01610882
23 Feasibility Study for PANDAS Completed NCT00754897
24 Characterization of Childhood-Onset Obsessive-Compulsive Disorder Completed NCT00044239
25 PANDA (Pediatric Anesthesia & NeuroDevelopment Assessment) Study Completed NCT00881764
26 Diffusion MRI for Pancreatic Adenocarcinoma Completed NCT02896946
27 Pantoprazole 20/40 mg in the Treatment of Symptomatic Reflux Disease With Focus on Sleep Disorders Completed NCT00830115
28 Cancer Detection in Pancreatic Cysts Completed NCT00222898
29 Intervention for Resistant Pregnant Smokers Completed NCT00005697
30 Primary Prevention of Atopic Disease by Perinatal Administration of Probiotics Completed NCT00200954
31 Parameters Analysis in Neurosurgical Critical Patients Through Big Data Acquisition Recruiting NCT03087981
32 Prenatal DHA and Neurofunctional Development Recruiting NCT02709239
33 Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS Recruiting NCT02889016
34 Pancreatoduodenectomy With or Without Ligamentum Teres Wrap Around Gastroduodenal Artery Stump for Prevention of Pancreatic Hemorrhage Recruiting NCT02588066
35 Prone or Supine Effect After Caesarean Delivery on Respiratory Outcomes in Full Term Infants Recruiting NCT02692573
36 Sodium Imbalance in Traumatic Brain Injury Patients: Prevalence, Predictors and Prognostic Significance in a Tertiary Care Centre Recruiting NCT02940834
37 RESIST: Understanding the Role of Depression in Heart Disease Recruiting NCT02657798
38 PANS - A Detailed Study of the Patients, Their Symptoms, Biomarkers and Treatment Offered in a Scandinavian Cohort Recruiting NCT02190292
39 Patient's Feelings After Receiving a Diagnosis of Age-related Macular Degeneration Not yet recruiting NCT03035461

Search NIH Clinical Center for Pandas

Genetic Tests for Pandas

Anatomical Context for Pandas

MalaCards organs/tissues related to Pandas:

39
Bone, Skin, Eye, Breast, Brain

Publications for Pandas

Articles related to Pandas:

(show top 50) (show all 231)
id Title Authors Year
1
Urinary profiles of luteinizing hormone, estrogen and progestagen during the estrous and gestational periods in giant pandas (Ailuropda melanoleuca). ( 28091600 )
2017
2
PANDAS in otolaryngology. ( 27882651 )
2017
3
Long Noncoding RNA PANDA Positively Regulates Proliferation of Osteosarcoma Cells. ( 28011477 )
2017
4
Habitat Use and Selection by Giant Pandas. ( 27627805 )
2016
5
Metabolic rates of giant pandas inform conservation strategies. ( 27264109 )
2016
6
Fatal canine distemper virus infection of giant pandas in China. ( 27310722 )
2016
7
Decreased microbial diversity and Lactobacillus group in the intestine of geriatric giant pandas (Ailuropoda melanoleuca). ( 27038949 )
2016
8
Microglial Dysregulation in OCD, Tourette Syndrome, and PANDAS. ( 28053994 )
2016
9
Eye care for ageing pandas. ( 27056806 )
2016
10
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) ( 26866234 )
2016
11
Corrigendum: Metabolic rates of giant pandas inform conservation strategies. ( 27650734 )
2016
12
PANDAS: A systematic review of treatment options. ( 27619047 )
2016
13
Analysis of the breast milk of giant pandas (Ailuropoda melanoleuca) and the preparation of substitutes. ( 26781707 )
2016
14
NORMAL VAGINAL BACTERIAL FLORA OF GIANT PANDAS (AILUROPODA MELANOLEUCA) AND THE ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF THE ISOLATES. ( 27010307 )
2016
15
Dietary Shifts May Trigger Dysbiosis and Mucous Stools in Giant Pandas (Ailuropoda melanoleuca). ( 27199976 )
2016
16
Obesity, PANDAS, Smoking, and Gun Violence. ( 26878177 )
2016
17
NORMAL VAGINAL BACTERIAL FLORA OF GIANT PANDAS (AILUROPODA MELANOLEUCA) AND THE ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF THE ISOLATES. ( 27468049 )
2016
18
Long Non-coding RNA, PANDA, Contributes to the Stabilization of p53 Tumor Suppressor Protein. ( 27069137 )
2016
19
Atmospheric deposition exposes Qinling pandas to toxic pollutants. ( 28039891 )
2016
20
Telemetry research on elusive wildlife: an synthesis of studies on giant pandas. ( 26940046 )
2016
21
Role of New Nature Reserve in Assisting Endangered Species Conservation - Case Study of Giant Pandas in the Northern Qionglai Mountains, China. ( 27532870 )
2016
22
Tonsillectomy remains a questionable option for pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). ( 28025607 )
2016
23
Influence of climate on the survivorship of neonatal red pandas in captivity. ( 26849175 )
2016
24
Complete Genome Sequence of emm4 Streptococcus pyogenes MEW427, a Throat Isolate from a Child Meeting Clinical Criteria for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS). ( 26988046 )
2016
25
Obsessive-Compulsive Disorder, Tics, and Autoinflammatory Diseases: Beyond PANDAS. ( 27854543 )
2016
26
Giant pandas (Carnivora: Ailuropoda melanoleuca) and living hominoids converge on lumbar vertebral adaptations to orthograde trunk posture. ( 26341032 )
2015
27
Implications for Advanced Practice Nurses When Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (PANDAS) Is Suspected: A Qualitative Study. ( 25895693 )
2015
28
The primary structure of COMT gene is not involved in the diet shift of the giant or the red pandas. ( 25748822 )
2015
29
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). ( 25502585 )
2015
30
First report of Enterocytozoon bieneusi from giant pandas (Ailuropoda melanoleuca) and red pandas (Ailurus fulgens) in China. ( 26079276 )
2015
31
The Role of Tonsillectomy in the Treatment of Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (PANDAS). ( 25569020 )
2015
32
Progress in the ecology and conservation of giant pandas. ( 26372302 )
2015
33
Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS): Experience at a Tertiary Referral Center. ( 26196024 )
2015
34
Is It PANS, CANS, or PANDAS? Neuropsychiatric Pediatric Disorders That Are Not Black and White-Implications for the School Nurse. ( 25816440 )
2015
35
PANDAS: The Need to Use Definitive Diagnostic Criteria. ( 26196028 )
2015
36
The evolution of the gut microbiota in the giant and the red pandas. ( 25985413 )
2015
37
DENTAL ABNORMALITIES OF EIGHT WILD QINLING GIANT PANDAS (AILUROPODA MELANOLEUCA QINLINGENSIS), SHAANXI PROVINCE, CHINA. ( 26280879 )
2015
38
Antimicrobial and Disinfectant Resistance of Escherichia coli Isolated from Giant Pandas. ( 25846200 )
2015
39
Endangered species. Captive pandas succumb to killer virus. ( 25678636 )
2015
40
Comparison of microhabitats and foraging strategies between the captive-born Zhangxiang and wild giant pandas: implications for future reintroduction. ( 26003090 )
2015
41
Low daily energy expenditure enables giant pandas to survive on bamboo. ( 26315826 )
2015
42
Chorea-St. Vitus, Sydenham or Pandas? ( 26540800 )
2015
43
Giant pandas failed to show mirror self-recognition. ( 25609263 )
2015
44
Ecological scale and seasonal heterogeneity in the spatial behaviors of giant pandas. ( 24447661 )
2014
45
Adelaide Zoo's giant pandas. ( 25180365 )
2014
46
Pandas love sweeties too. ( 24809562 )
2014
47
Giant Pandas Are Not an Evolutionary cul-de-sac: Evidence from Multidisciplinary Research. ( 25274274 )
2014
48
Sydenham Chorea and PANDAS in South Africa: Review of Evidence and Recommendations for Management in Resource-Poor Countries. ( 25227516 )
2014
49
The use of the gonadotropin-releasing hormone analog deslorelin for short-term contraception in red pandas (Ailurus fulgens). ( 24100162 )
2014
50
Evaluation of autoimmune phenomena in patients with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). ( 25151976 )
2014

Variations for Pandas

Expression for Pandas

Search GEO for disease gene expression data for Pandas.

Pathways for Pandas

GO Terms for Pandas

Sources for Pandas

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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