MCID: PNH001
MIFTS: 45

Panhypopituitarism malady

Endocrine diseases category
Download this MalaCard

Summaries for Panhypopituitarism

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced... more...

MalaCards: Panhypopituitarism, also known as panhypopituitarism nos, is related to empty sella syndrome and hypothyroidism. An important gene associated with Panhypopituitarism is SOX3 (SRY (sex determining region Y)-box 3). The compounds gnrh and acth have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and lung, and related mouse phenotypes are craniofacial and reproductive system.

Aliases & Classifications for Panhypopituitarism

About this section
Sources:
8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

panhypopituitarism 8 45 62
panhypopituitarism nos 8
simmonds' disease 8
simmond's disease 8


External Ids:

Disease Ontology8 DOID:9410
ICD9CM27 253.2
MeSH35 D007018

Related Diseases for Panhypopituitarism

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Panhypopituitarism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1empty sella syndrome30.3PROP1, LHX3
2hypothyroidism30.1PROP1, TSHB, HESX1, LHX3
3short stature30.1HESX1, PROP1
4growth hormone deficiency30.0SOX3, HESX1, PROP1
5pituitary tumors29.9PROP1, TSHB
6pituitary hypoplasia29.9PROP1, HESX1, SOX3, LHX3
7hypopituitarism29.9LHX3, SOX3, HESX1, PROP1
8acth deficiency29.8PROP1, HESX1
9septo-optic dysplasia29.7LHX3, HESX1, PROP1
10pituitary adenoma29.7PROP1, TSHB
11diabetes insipidus10.6
12aneurysm10.3
13addison's disease10.3
14craniopharyngioma10.2
15pituitary apoplexy10.2
16cushing's syndrome10.2
17breast cancer10.2
18germinoma10.2
19panhypopituitarism x-linked10.2
20hodgkin's lymphoma10.1
21hypogonadism10.1
22thyroiditis10.1
23chromophobe adenoma10.1
24progeria10.1
25paraplegia10.1
26intracranial aneurysm10.0
27sheehan syndrome10.0
28acromegaly10.0
29cleft lip10.0
30hypogonadotropism10.0
31central nervous system lymphoma10.0
32graves' disease10.0
33arthritis10.0
34diabetes mellitus10.0
35encephalitis10.0
36hyperthyroidism10.0
37leukemia10.0
38lung cancer10.0
39lupus erythematosus10.0
40meningitis10.0
41non-hodgkin lymphoma10.0
42prostatitis10.0
43sarcoidosis10.0
44hemorrhagic fever10.0
45lymphocytic hypophysitis10.0
46pituitary hormone deficiency, combined 210.0
47slipped capital femoral epiphysis10.0
48thyrotropin deficiency, isolated10.0PROP1, TSHB
49pituitary gland disease10.0LHX3, HESX1, PROP1
50kallmann syndrome9.9PROP1, HESX1, LHX3

Graphical network of the top 20 diseases related to Panhypopituitarism:



Diseases related to panhypopituitarism

Symptoms for Panhypopituitarism

About this section

Drugs & Therapeutics for Panhypopituitarism

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Panhypopituitarism

Search NIH Clinical Center for Panhypopituitarism

Genetic Tests for Panhypopituitarism

About this section

Anatomical Context for Panhypopituitarism

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Panhypopituitarism:

33
Pituitary, Brain, Lung, Bone, Breast, Thyroid, Prostate, Liver, Heart, Hypothalamus, Myeloid, B cells, Bone marrow, Pineal, Testes

Animal Models for Panhypopituitarism or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Panhypopituitarism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9LHX3, SOX3, HESX1
2MP:00053898.9PROP1, SOX3, LHX3
3MP:00053798.4PROP1, HESX1, SOX3, LHX3
4MP:00036318.4PROP1, HESX1, SOX3, LHX3
5MP:00107688.1PROP1, HESX1, SOX3, LHX3

Publications for Panhypopituitarism

About this section
Sources:
52PubMed
See all sources

Articles related to Panhypopituitarism:

(show top 50)    (show all 280)
idTitleAuthorsYear
1
Panhypopituitarism and lung neoplasm: A case study. (23769487)
2013
2
Cardiac effects of panhypopituitarism in a 71-year-old woman. (24344143)
2013
3
A case of possible neurosarcoidosis presenting as intractable headache and panhypopituitarism. (23991342)
2013
4
Panhypopituitarism presenting as life-threatening heart failure caused by an inherited microdeletion in 1q25 including LHX4. (22232309)
2012
5
Panhypopituitarism and diabetes insipidus in a patient with primary central nervous system lymphoma. (22563813)
2012
6
Panhypopituitarism with empty sella a sequel of pituitary hyperplasia due to chronic primary hypothyroidism. (23565400)
2012
7
Macroorchidism and panhypopituitarism: two different forms of presentation of FSH-secreting pituitary adenomas in adolescence. (21196695)
2011
8
Slipped capital femoral epiphysis in an adult with panhypopituitarism. (21410117)
2011
9
Esophageal achalasia with panhypopituitarism: a rare association. (21342335)
2011
10
Response to growth hormone therapy in adolescents with familial panhypopituitarism. (20431169)
2010
11
Pituitary abscess with panhypopituitarism showing T1 signal hyperintensity of the marginal pituitary area: a non-invasive differential diagnosis of pituitary abscess and pituitary apoplexy. (19293544)
2009
12
Diabetes insipidus, panhypopituitarism, and severe mental status deterioration in a patient with chordoid glioma: case report and literature review. (19364693)
2009
13
A novel congenital ichthyosiform syndrome with associated panhypopituitarism, corneal opacities and mental retardation. (17786459)
2007
14
Panhypopituitarism as first manifestation of a lung cancer. (17272231)
2007
15
Mycobacterium avium complex lung disease and panhypopituitarism. (16007905)
2005
16
Panhypopituitarism and hydrocephalus with cerebrospinal fluid shunting following total hypophysectomy: case report of a successful pregnancy. (16147702)
2005
17
Case 1. Metastatic breast cancer presenting with panhypopituitarism. (15570089)
2004
18
Childhood panhypopituitarism presenting as child abuse: a case report and review of the literature. (15322473)
2004
19
Panhypopituitarism in a patient with breast cancer. (15585980)
2004
20
Basal meningoencephalocele, anomaly of optic disc and panhypopituitarism in association with moyamoya disease. (11070437)
2000
21
Evolution of childhood central diabetes insipidus into panhypopituitarism with a large hypothalamic mass: is 'lymphocytic infundibuloneurohypophysitis' in children a different entity? (9916870)
1998
22
Effect of growth hormone on fatty liver in panhypopituitarism. (9245856)
1997
23
Restoration by corticosteroids of the hyperaldosteronism in hyponatraemic rats with panhypopituitarism. (7834996)
1994
24
Serum growth hormone-binding protein is unchanged in adult panhypopituitarism. (7962328)
1994
25
Hypophyseal non-Hodgkin's lymphoma presenting with clinical panhypopituitarism successfully treated with chemotherapy. (8145058)
1993
26
Case report: hypothalamic tuberculoma associated with secondary panhypopituitarism. (8362890)
1993
27
A case of glomerular lipidosis accompanied by familial combined hyperlipidemia and panhypopituitarism. (1568042)
1992
28
Acquired anhaptoglobinemia in panhypopituitarism. (3993662)
1985
29
Effects of DDAVP and venous occlusion on the release of tissue-type plasminogen activator and von Willebrand factor in patients with panhypopituitarism. (6609451)
1984
30
The renin-angiotensin system in panhypopituitarism: dynamic studies and therapeutic effects in Sheehan's syndrome. (6339539)
1983
31
Plasma aldosterone response to acute stimulation in panhypopituitarism. (6267858)
1981
32
Nocturnal diuresis in panhypopituitarism. (682967)
1978
33
Primary empty sella syndrome with panhypopituitarism, diabetes insipidus, and visual field defects. (707005)
1978
34
The sulpiride test in panhypopituitarism. (639330)
1978
35
Diabetes insipidus and panhypopituitarism after pituitary infarction in a case of acromegaly. (890301)
1977
36
Permanent panhypopituitarism associated with maternal deprivation. (805525)
1975
37
Hypothalamic hypopituitarism. A case of panhypopituitarism with TSH and LH deficiency of hypothalamic origin. (4196985)
1973
38
Panhypopituitarism due to multiple myeloma. (5415797)
1970
39
CORTICOSTEROID-INDUCED ATROPHY OF THE HUMAN ADRENALS COMPARABLE TO PANHYPOPITUITARISM; A HISTOPATHOLOGICAL STUDY. (14222347)
1964
40
Hyperlipemia and panhypopituitarism. Report of 2 cases. (14025942)
1963
41
Sheehan's syndrome (postpartum panhypopituitarism). (13646936)
1959
42
Pituitary cyst with panhypopituitarism: radio-opaque visualization and treatment by transfrontal and transsphenoidal decompression and interstitial radiation with radioactive cobalt. (13486331)
1957
43
Large intracranial aneurysm producing panhypopituitarism and frontal lobe syndrome. (13378585)
1956
44
Panhypopituitarism is easily missed. (14367981)
1955
45
The use of cortisone in the treatment of the panhypopituitarism due to postpartum necrosis of the pituitary (Sheehan's syndrome). (13116420)
1954
46
Arthritis and panhypopituitarism. (13084730)
1953
47
Panhypopituitarism, lupus erythematosus and hallucinosis. (13009999)
1952
48
The variability of the lowered glomerular filtration rate in Addison's disease and panhypopituitarism, and the effect of cortisone thereon. (14936287)
1952
49
Differential blood counts in certain adrenal cortical disorders (Cushing's syndrome, Addison's disease and panhypopituitarism). (21025124)
1946
50
Craniopharyngioma with panhypopituitarism; case report with clinical and pathological study. (20288018)
1946

Variations for Panhypopituitarism

About this section

Expression for genes affiliated with Panhypopituitarism

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Panhypopituitarism

Search GEO for disease gene expression data for Panhypopituitarism.

Pathways for genes affiliated with Panhypopituitarism

About this section

Compounds for genes affiliated with Panhypopituitarism

About this section
Sources:
45Novoseek
See all sources

Compounds related to Panhypopituitarism according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gnrh458.8PROP1, HESX1, LHX3
2acth458.2PROP1, TSHB, HESX1

GO Terms for genes affiliated with Panhypopituitarism

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Panhypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.0PROP1, LHX3
2nucleusGO:0056348.4PROP1, HESX1, SOX3, LHX3

Biological processes related to Panhypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pituitary gland developmentGO:0219839.4SOX3, LHX3
2central nervous system developmentGO:0074179.4PROP1, SOX3
3organ morphogenesisGO:0098879.2SOX3, LHX3

Molecular functions related to Panhypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin bindingGO:0036829.3PROP1, HESX1
2protein C-terminus bindingGO:0080229.0PROP1, HESX1
3sequence-specific DNA binding transcription factor activityGO:0037008.7PROP1, HESX1, LHX3

Products for genes affiliated with Panhypopituitarism

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Panhypopituitarism

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet