MCID: PNH001
MIFTS: 55

Panhypopituitarism malady

Summaries for Panhypopituitarism

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced... more...

MalaCards: Panhypopituitarism, also known as panhypopituitarism nos, is related to diabetes insipidus and empty sella syndrome. An important gene associated with Panhypopituitarism is SOX3 (SRY (sex determining region Y)-box 3), and among its related pathways are Glucocorticoid receptor regulatory network and Insulin Processing. The compounds estrogen and dopamine have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and lung, and related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Aliases & Classifications for Panhypopituitarism

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

panhypopituitarism 8 44 60
panhypopituitarism nos 8
simmond's disease 8
simmonds' disease 8


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Disease Ontology8 DOID:9410
MeSH34 D007018
ICD9CM27 253.2

Related Diseases for Panhypopituitarism

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17GeneCards, 18GeneDecks
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Diseases related to Panhypopituitarism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus30.8AVP, POMC, PRL
2empty sella syndrome30.3POMC, PRL
3pituitary apoplexy30.2PRL, POMC
4craniopharyngioma30.2PRL, PROP1, IGF1, POMC, AVP, GH1
5hypothyroidism30.2TSHB, AVP, POMC, POU1F1, IGF1, PROP1
6cushing's syndrome30.2POMC, GH1
7breast cancer30.1POU1F1, IGFBP1, ALPP, GH1, IGF1, CALCA
8chromophobe adenoma30.1PRL, GH1
9meningitis30.1AVP
10thyroiditis30.1POMC, CALCA
11hypogonadism30.0POMC, POU1F1, IGF1, PROP1, PRL, GH1
12hypogonadotropism29.9PRL
13lung cancer29.9IGF1, POMC
14acromegaly29.9IGF1, GH1, PRL
15sheehan syndrome29.9IGF1, PRL, POMC
16pituitary hypoplasia29.9POU1F1, PROP1, LHX4, SOX3, LHX3, HESX1
17leukemia29.9IGFBP1, ALPP, GHR
18lung small cell carcinoma29.9CALCA, SOX3, POMC, AVP
19arthritis29.9POMC, ALPP, CALCA, GHRL
20hyperthyroidism29.9TSHB, ALPP, IGF1, GH1, GHRL, GHR
21diabetes mellitus29.9ALPP, POMC, IGF1, CALCA, GHR, GHRL
22hypopituitarism29.9PROP1, LHX3, HESX1, LHX4, GH1, PRL
23nephrotic syndrome29.7POMC
24systemic lupus erythematosus29.7PRL
25histiocytosis29.7S100B
26cholestasis29.7ALPP
27rheumatoid arthritis29.7GHRL
28pancreatitis29.7ALPP
29pituitary cancer29.7POMC, PRL
30thyroid cancer29.7CALCA
31infertility29.7IGFBP1, PRL
32cryptorchidism29.7ALPP
33myocardial infarction29.7IGFBP1, GHRL
34amenorrhea29.7PRL, IGF1, POMC
35osteoporosis29.7CALCA, GHR, GH1, IGF1, ALPP
36anorexia nervosa29.7IGF1, POMC, GHR, GHRL, PRL, GH1
37obesity29.7HESX1, GHR, GH1, IGFBP1, PROP1, IGF1
38pituitary adenoma29.7POU1F1, GHR, IGF1, PROP1, PRL, GH1
39adenoma29.7CALCA, GHR, TSHB, POMC, POU1F1, IGF1
40addison's disease10.2
41panhypopituitarism x-linked10.1
42progeria10.1
43paraplegia10.1
44central nervous system lymphoma10.1
45cleft palate10.1
46hodgkin's lymphoma10.1
47congestive heart failure10.0AVP
48panic disorder10.0POMC
49nephrogenic diabetes insipidus10.0AVP
50adrenocortical carcinoma10.0POMC

Graphical network of the top 20 diseases related to Panhypopituitarism:



Diseases related to panhypopituitarism

Clinical Features for Panhypopituitarism

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Drugs & Therapeutics for Panhypopituitarism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Genetic Tests for Panhypopituitarism

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Anatomical Context for Panhypopituitarism

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32MalaCards
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MalaCards organs/tissues related to Panhypopituitarism:

32
Pituitary, Brain, Lung, Bone, Breast, Thyroid, Prostate, Hypothalamus, Heart, Liver, Myeloid, B cells, Bone marrow, Pineal, Testes

Animal Models for Panhypopituitarism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Panhypopituitarism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.5POU1F1, PROP1, GHR, SOX3, HESX1, LHX3
2MP:00053759.1POMC, IGF1, GH1, GHRL, GHR
3MP:00028738.2GHRL, S100B, HESX1, HDX, CALCA, IGF1
4MP:00053897.9SOX3, GHR, GH1, PRL, PROP1, IGF1
5MP:00053867.9PRL, S100B, SOX3, GHR, GHRL, PROP1
6MP:00053787.7IGF1, POU1F1, POMC, SMPD3, PROP1, GH1
7MP:00036317.3SOX3, HESX1, CALCA, LHX3, LHX4, GHR
8MP:00107687.2SMPD3, LHX3, HESX1, SOX3, GHR, PROP1
9MP:00053767.1GH1, SMPD3, AVP, POMC, LHX4, LHX3

Publications for Panhypopituitarism

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50PubMed
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Articles related to Panhypopituitarism:

(show top 50)    (show all 289)
idTitleAuthorsYear
1
Wegener granulomatosis as an uncommon cause of panhypopituitarism in childhood. (23729544)
2013
2
Growth retardation due to panhypopituitarism and central diabetes insipidus following Russell's viper bite. (24050105)
2013
3
A Case of QT Prolongation Associated with Panhypopituitarism. (23762665)
2013
4
Panhypopituitarism presenting as life-threatening heart failure caused by an inherited microdeletion in 1q25 including LHX4. (22232309)
2012
5
Panhypopituitarism and diabetes insipidus in a patient with primary central nervous system lymphoma. (22563813)
2012
6
Hepatopathy in an adult, secondary to congenital untreated panhypopituitarism and ectopic posterior pituitary gland. (23087873)
2012
7
Macroorchidism and panhypopituitarism: two different forms of presentation of FSH-secreting pituitary adenomas in adolescence. (21196695)
2011
8
Panhypopituitarism secondary to a macroprolactinoma manifesting with pancytopenia: case report and literature review. (21247847)
2011
9
Panhypopituitarism due to Wegener's granulomatosis. (22147097)
2011
10
Balloon-assisted coiling of the proximal lobule of a paraophthalmic aneurysm causing panhypopituitarism: Technical case report. (21697971)
2011
11
Successful pregnancy and delivery in a woman with panhypopituitarism. (21503236)
2007
12
Pulmonary Mycobacterium avium complex infection in patients with panhypopituitarism not receiving hormone replacement therapy. (15704788)
2005
13
Diabetes insipidus and panhypopituitarism revealing pituitary metastasis of small cell lung carcinoma: a case report. (15959412)
2005
14
Childhood panhypopituitarism presenting as child abuse: a case report and review of the literature. (15322473)
2004
15
From panhypopituitarism to combined pituitary deficiencies: do we need the anterior pituitary? (14966385)
2004
16
Hypophyseal hemorrhage and panhypopituitarism during Puumala Virus Infection: Magnetic Resonance Imaging and detection of viral antigen in the hypophysis. (12060884)
2002
17
Bacterial pituitary abscess: an unusual cause of panhypopituitarism. (15251832)
2002
18
A relapsed non-Hodgkin lymphoma presenting as panhypopituitarism successfully treated by chemotherapy. (12222836)
2002
19
An unusual pituitary mass presenting with panhypopituitarism and hyponatraemia. (11470937)
2001
20
Effect of long-term treatment with recombinant human growth hormone on erythropoietin secretion in an anemic patient with panhypopituitarism. (10698049)
2000
21
Multifocal fibrosclerosis as a possible cause of panhypopituitarism with central diabetes insipidus. (11036878)
2000
22
Successful pregnancy and birth after sequential cotreatment with growth hormone and gonadotropins in a woman with panhypopituitarism: a new treatment protocol. (11119761)
2000
23
Non-Hodgkin lymphoma with panhypopituitarism, hyperprolactinaemia and sixth nerve palsy. (9204025)
1997
24
Hyponatremia caused by a reset osmostat in a neonate with cleft lip and palate and panhypopituitarism. (8618194)
1996
25
Panhypopituitarism after cavernous sinus thrombosis. (8057098)
1994
26
A case of glomerular lipidosis accompanied by familial combined hyperlipidemia and panhypopituitarism. (1568042)
1992
27
Successful weight loss with protein-sparing modified fast in a morbidly obese boy with panhypopituitarism, diabetes insipidus, and defective thirst regulation. (1563198)
1992
28
Gradual progress of ACTH deficiency in a child with panhypopituitarism associated with pituitary stalk transection. (1327727)
1992
29
Spontaneous pituitary apoplexy with transient panhypopituitarism and diabetes insipidus. (1645916)
1991
30
Pregnancy in panhypopituitarism. (2358198)
1990
31
Sexual behavior of men with isolated hypogonadotropic hypogonadism or prepubertal anterior panhypopituitarism. (2365300)
1990
32
Panhypopituitarism secondary to an aneurysm of the anterior communicating artery. (3304601)
1987
33
Panhypopituitarism in a young drug abuser. (3957192)
1986
34
Acquired anhaptoglobinemia in panhypopituitarism. (3993662)
1985
35
Survival and growth in a woman with untreated hypothalamic panhypopituitarism of 21 years' duration. (4370418)
1974
36
Paradoxical response of plasma cortisol to pulse intravenous injection of synthetic corticotrophin and dibutyryl cyclic adenosine 3',5'-monophosphate in adult panhypopituitarism. (4355074)
1973
37
Plasma renin activity in panhypopituitarism. Responses to sodium restriction, furosemide and corticotrophin administration. (4111287)
1972
38
Puerperal diabetes insipidus and panhypopituitarism. Report of a case. (5815394)
1969
39
EFFECT OF HUMAN GROWTH HORMONE ON INSULIN PRODUCTION IN PANHYPOPITUITARISM. (14160547)
1964
40
Hyperlipemia and panhypopituitarism. Report of 2 cases. (14025942)
1963
41
PANHYPOPITUITARISM CAUSED BY HAND-SCHUELLER-CHRISTIAN DISEASE. (14098895)
1963
42
Pituitary insufficiency associated with pregnancy, panhypopituitarism, and diabetes insipidus. (13866539)
1962
43
Panhypopituitarism and the effect on the adernal gland. (13747045)
1961
44
The adrenocortical response to corticotrophin in Addison's disease and panhypopituitarism. (13638211)
1959
45
Pathologic findings in a case of panhypopituitarism and diabetes insipidus; comments relative to hypothalamic, pituitary, and end-organ interrelationships. (13570809)
1958
46
Simmonds-Sheehan's disease; hypophysial insufficiency, panhypopituitarism. (14398074)
1955
47
Pluriglandular insufficiency without panhypopituitarism. (13270174)
1955
48
Panhypopituitarism, lupus erythematosus and hallucinosis. (13009999)
1952
49
The effect of adrenocorticotrophic hormone in patients with panhypopituitarism. (18908514)
1947
50
Differential blood counts in certain adrenal cortical disorders (Cushing's syndrome, Addison's disease and panhypopituitarism). (21025124)
1946

Genetic Variations for Panhypopituitarism

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Expression for genes affiliated with Panhypopituitarism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Panhypopituitarism

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Pathways for genes affiliated with Panhypopituitarism

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37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Panhypopituitarism

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Panhypopituitarism according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7TSHB
2dopamine44 28 11 2413.0GHRL, GHR, IGF1
3estradiol44 11 2411.9POMC, GHR, PRL
4bromocriptine28 44 1111.9POU1F1, POMC, PRL, GHR
5deoxypyridinoline449.9GH1, IGFBP1, CALCA
6dehydroepiandrosterone sulfate449.9IGFBP1, GH1, POMC, GHR
7forskolin44 49 1111.8CALCA, POMC, POU1F1
8leuprolide acetate449.8PRL, GH1, GHR, IGF1
9naltrexone44 49 28 1112.7GH1, IGF1, POMC, PRL
10clomiphene citrate449.6GH1, PRL, IGFBP1, IGF1
11ether449.6POMC, CALCA, GHRL, AVP
12cabergoline28 44 1111.6PRL, IGF1, GHR, GH1
13quinagolide449.6GH1, IGF1, PRL
14pirenzepine44 28 1111.6GHRL, IGF1, IGFBP1, GH1
15buserelin44 28 1111.6IGFBP1, CALCA, IGF1, PRL
16lanreotide44 2810.5IGF1, IGFBP1, GH1, GHR, PRL
17ghrp449.5GH1, GHR, IGF1, GHRL, PRL
18pyridostigmine44 1110.4GHRL, IGFBP1, IGF1, GH1, PRL
19pegvisomant44 1110.4GHR, GHRL, IGF1, GH1, IGFBP1
20metformin44 49 1111.4GH1, GHRL, IGFBP1, IGF1, POMC
21c-peptide449.3IGF1, IGFBP1, GH1, GHRL, GHR
22hexarelin44 2810.3PRL, IGF1, GHRL, POMC, GHR, GH1
23pyridinoline449.3CALCA, ALPP, IGF1, GH1
242-deoxyglucose44 1110.2GHRL, POMC, CALCA, IGF1, IGFBP1
25androstenedione44 2410.2IGF1, POMC, IGFBP1, PRL, GH1, GHR
26clonidine44 28 1111.2POMC, PRL, IGF1, CALCA, GHR, GH1
27gnrh449.2LHX3, HESX1, GHR, GHRL, GH1, PROP1
28dhea449.2POMC, IGF1, IGFBP1, PRL, GHRL, GH1
29glucose449.1GHRL, POMC, AVP, IGF1
30norepinephrine44 11 2411.1CALCA, S100B, PRL, POMC, ALPP, AVP
31corticosterone44 59 2411.1IGFBP1, POMC, PRL, GHRL, GH1, CALCA
32progestin449.0IGF1, IGFBP1, PRL, POMC, ALPP
33creatinine448.8POMC, IGF1, ALPP, AVP, GHR, IGFBP1
34triiodothyronine448.8POMC, TSHB, IGF1, IGFBP1, PRL, GH1
35calcitriol44 59 11 2411.8IGF1, GHR, CALCA, GH1, IGFBP1, ALPP
36alanine448.7SOX3, GHRL, GH1, POU1F1, POMC, ALPP
37epinephrine44 11 2410.7POMC, IGFBP1, GH1, GHRL, CALCA, PRL
38chloramphenicol44 2 1110.7GHR, GH1, TSHB, ALPP, IGFBP1, S100B
39progesterone44 59 28 11 2412.6S100B, GHR, GH1, PRL, IGFBP1, IGF1
40octreotide44 59 28 1111.6POMC, CALCA, GHRL, GH1, PRL, IGFBP1
41ribonucleic acid448.6TSHB, POMC, IGF1, IGFBP1, PRL, GH1
42steroid448.4IGFBP1, PROP1, GH1, GHR, S100B, POU1F1
43hydrocortisone44 2 59 1111.4ALPP, CALCA, POMC, IGF1, IGFBP1, PRL
44vitamin d448.4GHRL, GHR, IGFBP1, CALCA, GH1, ALPP
45thymidine44 249.2IGF1, GH1, GHRL, GHR, S100B, IGFBP1
46thyroxine44 249.0GH1, PRL, IGFBP1, GHRL, IGF1, GHR
47dexamethasone44 49 28 1110.8ALPP, GHR, S100B, AVP, POMC, POU1F1
48arginine447.8IGFBP1, IGF1, POU1F1, POMC, ALPP, PRL
49acth447.8GHR, S100B, POU1F1, HESX1, TSHB, GHRL
50testosterone44 59 11 2410.7ALPP, POMC, IGF1, PRL, CALCA, S100B

GO Terms for genes affiliated with Panhypopituitarism

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16Gene Ontology
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Cellular components related to Panhypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.9POMC, GHRL
2secretory granuleGO:0301419.5AVP, POMC, PRL
3extracellular spaceGO:0056157.8CALCA, S100B, GHR, GHRL, GH1, IGFBP1
4extracellular regionGO:0055767.5TSHB, CALCA, S100B, GHR, GHRL, GH1

Biological processes related to Panhypopituitarism according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1medial motor column neuron differentiationGO:02152610.3LHX3, LHX4
2growth hormone receptor signaling pathwayGO:06039610.2GH1, GHR
3organ morphogenesisGO:00988710.0LHX4, LHX3, SOX3
4negative regulation of release of cytochrome c from mitochondriaGO:09020110.0AVP, IGF1
5positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.0IGF1, GH1
6JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.0PRL, GH1, GHR
7positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.0GHR, GH1, IGF1
8response to estradiol stimulusGO:03235510.0PRL, GH1, GHR
9regulation of multicellular organism growthGO:04001410.0GHR, PRL, IGF1
10insulin-like growth factor receptor signaling pathwayGO:0480099.9IGF1, GHR
11positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.9GHR, GH1, IGF1
12positive regulation of JAK-STAT cascadeGO:0464279.9GH1, PRL
13positive regulation of multicellular organism growthGO:0400189.7POU1F1, GH1, GHRL, GHR
14cell-cell signalingGO:0072679.7TSHB, AVP, POMC, CALCA
15negative regulation of apoptotic processGO:0430669.6LHX4, LHX3, GHRL, PROP1, AVP
16cellular protein metabolic processGO:0442679.3GHRL, IGFBP1, IGF1, POMC, TSHB
17elevation of cytosolic calcium ion concentrationGO:0072049.3AVP, GHRL, CALCA

Molecular functions related to Panhypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:0051489.9PRL, GH1
2sequence-specific DNA binding transcription factor activityGO:0037009.3POU1F1, PROP1, HDX, HESX1, LHX3, LHX4
3sequence-specific DNA bindingGO:0435659.2LHX4, LHX3, HESX1, HDX, POU1F1
4hormone activityGO:0051798.9TSHB, CALCA, GH1, PRL, IGF1, POMC

Products for genes affiliated with Panhypopituitarism

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Sources for Panhypopituitarism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet