MCID: PNH001
MIFTS: 46

Panhypopituitarism malady

Endocrine diseases category
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Summaries for Panhypopituitarism

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Wikipedia:65 Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced... more...

MalaCards based summary: Panhypopituitarism, also known as simmond's disease, is related to empty sella syndrome and short stature. An important gene associated with Panhypopituitarism is SOX3 (SRY (sex determining region Y)-box 3). The compounds gnrh and acth have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and lung, and related mouse phenotypes are craniofacial and reproductive system.

Aliases & Classifications for Panhypopituitarism

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 27ICD9CM, 34MeSH, 57SNOMED-CT
See all sources

Panhypopituitarism, Aliases & Descriptions:

Name: Panhypopituitarism 8 44 62
Simmond's Disease 8 62
 
Panhypopituitarism Nos 8
Simmonds' Disease 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:9410
ICD9CM27 253.2
MeSH34 D007018

Related Diseases for Panhypopituitarism

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Diseases related to Panhypopituitarism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 141)
idRelated DiseaseScoreTop Affiliating Genes
1empty sella syndrome30.3PROP1, LHX3
2short stature30.1HESX1, PROP1
3acth deficiency29.9PROP1, HESX1
4growth hormone deficiency29.8SOX3, HESX1, PROP1
5septo-optic dysplasia29.6LHX3, HESX1, PROP1
6pituitary tumors29.6PROP1, TSHB
7pituitary adenoma29.6PROP1, TSHB
8hypothyroidism29.6PROP1, TSHB, HESX1, LHX3
9pituitary hypoplasia29.5PROP1, HESX1, SOX3, LHX3
10hypopituitarism29.5LHX3, SOX3, HESX1, PROP1
11holoprosencephaly29.3LHX3, SOX3, HESX1, PROP1
12diabetes insipidus10.6
13aneurysm10.3
14addison's disease10.3
15craniopharyngioma10.2
16pituitary apoplexy10.2
17cushing's syndrome10.2
18germinoma10.2
19breast cancer10.2
20hypogonadism10.2
21panhypopituitarism x-linked10.2
22hodgkin's lymphoma10.1
23hypogonadotropism10.1
24sheehan syndrome10.1
25meningitis10.1
26thyroiditis10.1
27chromophobe adenoma10.1
28progeria10.1
29paraplegia10.1
30arthritis10.0
31diabetes mellitus10.0
32leukemia10.0
33non-hodgkin lymphoma10.0
34acromegaly10.0
35cleft lip10.0
36graves' disease10.0
37intracranial aneurysm10.0
38central nervous system lymphoma10.0
39encephalitis10.0
40hyperthyroidism10.0
41lung cancer10.0
42lupus erythematosus10.0
43prostatitis10.0
44sarcoidosis10.0
45hemorrhagic fever10.0
46lymphocytic hypophysitis10.0
47pituitary hormone deficiency, combined 210.0
48slipped capital femoral epiphysis10.0
49combined pituitary hormone deficiency10.0
50headache10.0

Graphical network of the top 20 diseases related to Panhypopituitarism:



Diseases related to panhypopituitarism

Symptoms for Panhypopituitarism

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Drugs & Therapeutics for Panhypopituitarism

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Drug clinical trials:

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Search NIH Clinical Center for Panhypopituitarism

Genetic Tests for Panhypopituitarism

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Anatomical Context for Panhypopituitarism

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MalaCards organs/tissues related to Panhypopituitarism:

32
Pituitary, Brain, Lung, Bone, Breast, Thyroid, Heart, Liver, Prostate, B cells, Hypothalamus, Bone marrow, Testes, Myeloid, Pineal, Neutrophil

Animal Models for Panhypopituitarism or affiliated genes

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MGI Mouse Phenotypes related to Panhypopituitarism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9LHX3, SOX3, HESX1
2MP:00053898.9PROP1, SOX3, LHX3
3MP:00053798.4PROP1, HESX1, SOX3, LHX3
4MP:00036318.4PROP1, HESX1, SOX3, LHX3
5MP:00107688.1PROP1, HESX1, SOX3, LHX3

Publications for Panhypopituitarism

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Articles related to Panhypopituitarism:

(show top 50)    (show all 293)
idTitleAuthorsYear
1
Holoprosencephaly: ZIC2 mutation in a case with panhypopituitarism. (24706429)
2014
2
Epithelioid inflammatory myofibroblastic sarcoma responsive to surgery and an ALK inhibitor in a patient with panhypopituitarism. (25274232)
2014
3
Panhypopituitarism and lung neoplasm: A case study. (23769487)
2013
4
Cardiac effects of panhypopituitarism in a 71-year-old woman. (24344143)
2013
5
A case of possible neurosarcoidosis presenting as intractable headache and panhypopituitarism. (23991342)
2013
6
Panhypopituitarism presenting as life-threatening heart failure caused by an inherited microdeletion in 1q25 including LHX4. (22232309)
2012
7
Panhypopituitarism and diabetes insipidus in a patient with primary central nervous system lymphoma. (22563813)
2012
8
Panhypopituitarism with empty sella a sequel of pituitary hyperplasia due to chronic primary hypothyroidism. (23565400)
2012
9
Macroorchidism and panhypopituitarism: two different forms of presentation of FSH-secreting pituitary adenomas in adolescence. (21196695)
2011
10
Slipped capital femoral epiphysis in an adult with panhypopituitarism. (21410117)
2011
11
Esophageal achalasia with panhypopituitarism: a rare association. (21342335)
2011
12
Response to growth hormone therapy in adolescents with familial panhypopituitarism. (20431169)
2010
13
Pituitary abscess with panhypopituitarism showing T1 signal hyperintensity of the marginal pituitary area: a non-invasive differential diagnosis of pituitary abscess and pituitary apoplexy. (19293544)
2009
14
Diabetes insipidus, panhypopituitarism, and severe mental status deterioration in a patient with chordoid glioma: case report and literature review. (19364693)
2009
15
A novel congenital ichthyosiform syndrome with associated panhypopituitarism, corneal opacities and mental retardation. (17786459)
2007
16
Panhypopituitarism as first manifestation of a lung cancer. (17272231)
2007
17
Mycobacterium avium complex lung disease and panhypopituitarism. (16007905)
2005
18
Panhypopituitarism and hydrocephalus with cerebrospinal fluid shunting following total hypophysectomy: case report of a successful pregnancy. (16147702)
2005
19
Case 1. Metastatic breast cancer presenting with panhypopituitarism. (15570089)
2004
20
Panhypopituitarism in a patient with breast cancer. (15585980)
2004
21
Basal meningoencephalocele, anomaly of optic disc and panhypopituitarism in association with moyamoya disease. (11070437)
2000
22
Evolution of childhood central diabetes insipidus into panhypopituitarism with a large hypothalamic mass: is 'lymphocytic infundibuloneurohypophysitis' in children a different entity? (9916870)
1998
23
Effect of growth hormone on fatty liver in panhypopituitarism. (9245856)
1997
24
Restoration by corticosteroids of the hyperaldosteronism in hyponatraemic rats with panhypopituitarism. (7834996)
1994
25
Serum growth hormone-binding protein is unchanged in adult panhypopituitarism. (7962328)
1994
26
Hypophyseal non-Hodgkin's lymphoma presenting with clinical panhypopituitarism successfully treated with chemotherapy. (8145058)
1993
27
Case report: hypothalamic tuberculoma associated with secondary panhypopituitarism. (8362890)
1993
28
A case of glomerular lipidosis accompanied by familial combined hyperlipidemia and panhypopituitarism. (1568042)
1992
29
Acquired anhaptoglobinemia in panhypopituitarism. (3993662)
1985
30
Effects of DDAVP and venous occlusion on the release of tissue-type plasminogen activator and von Willebrand factor in patients with panhypopituitarism. (6609451)
1984
31
The renin-angiotensin system in panhypopituitarism: dynamic studies and therapeutic effects in Sheehan's syndrome. (6339539)
1983
32
Plasma aldosterone response to acute stimulation in panhypopituitarism. (6267858)
1981
33
Nocturnal diuresis in panhypopituitarism. (682967)
1978
34
Primary empty sella syndrome with panhypopituitarism, diabetes insipidus, and visual field defects. (707005)
1978
35
The sulpiride test in panhypopituitarism. (639330)
1978
36
Diabetes insipidus and panhypopituitarism after pituitary infarction in a case of acromegaly. (890301)
1977
37
Permanent panhypopituitarism associated with maternal deprivation. (805525)
1975
38
Hypothalamic hypopituitarism. A case of panhypopituitarism with TSH and LH deficiency of hypothalamic origin. (4196985)
1973
39
Panhypopituitarism due to multiple myeloma. (5415797)
1970
40
Hyperlipemia and panhypopituitarism. Report of 2 cases. (14025942)
1963
41
Sheehan's syndrome (postpartum panhypopituitarism). (13646936)
1959
42
Pituitary cyst with panhypopituitarism: radio-opaque visualization and treatment by transfrontal and transsphenoidal decompression and interstitial radiation with radioactive cobalt. (13486331)
1957
43
Large intracranial aneurysm producing panhypopituitarism and frontal lobe syndrome. (13378585)
1956
44
Panhypopituitarism is easily missed. (14367981)
1955
45
The use of cortisone in the treatment of the panhypopituitarism due to postpartum necrosis of the pituitary (Sheehan's syndrome). (13116420)
1954
46
Arthritis and panhypopituitarism. (13084730)
1953
47
Panhypopituitarism, lupus erythematosus and hallucinosis. (13009999)
1952
48
The variability of the lowered glomerular filtration rate in Addison's disease and panhypopituitarism, and the effect of cortisone thereon. (14936287)
1952
49
Differential blood counts in certain adrenal cortical disorders (Cushing's syndrome, Addison's disease and panhypopituitarism). (21025124)
1946
50
Craniopharyngioma with panhypopituitarism; case report with clinical and pathological study. (20288018)
1946

Variations for Panhypopituitarism

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Expression for genes affiliated with Panhypopituitarism

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Expression patterns in normal tissues for genes affiliated with Panhypopituitarism

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Pathways for genes affiliated with Panhypopituitarism

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Compounds for genes affiliated with Panhypopituitarism

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Sources:
44Novoseek
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Compounds related to Panhypopituitarism according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gnrh448.8PROP1, HESX1, LHX3
2acth448.2PROP1, TSHB, HESX1

GO Terms for genes affiliated with Panhypopituitarism

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Cellular components related to Panhypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.0PROP1, LHX3
2nucleusGO:0056348.4PROP1, HESX1, SOX3, LHX3

Biological processes related to Panhypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pituitary gland developmentGO:0219839.4SOX3, LHX3
2central nervous system developmentGO:0074179.4PROP1, SOX3
3organ morphogenesisGO:0098879.2SOX3, LHX3

Molecular functions related to Panhypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin bindingGO:0036829.3PROP1, HESX1
2protein C-terminus bindingGO:0080229.0PROP1, HESX1
3sequence-specific DNA binding transcription factor activityGO:0037008.7PROP1, HESX1, LHX3

Products for genes affiliated with Panhypopituitarism

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Sources for Panhypopituitarism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet