Panhypopituitarism malady

Genetics Home Reference: Combined pituitary hormone deficiency is a condition that causes a shortage (deficiency) of several hormones produced by the pituitary gland, which is located at the base of the brain. A lack of these hormones may affect the development of many parts of the body. The first signs of this condition include a failure to grow at the expected rate and short stature that usually becomes apparent in early childhood.¹⁷

MalaCards: Panhypopituitarism, also known as panhypopituitarism nos (disorder), is related to panhypopituitarism x-linked and sheehan syndrome. An important gene associated with Panhypopituitarism is SOX3 (SRY (sex determining region Y)-box 3), and among its related pathways are G alpha (s) signalling events and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The compounds estradiol and deoxypyridinoline have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and prostate, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia: Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced...⁴⁴ more...

Aliases & Descriptions:

panhypopituitarism 6 7 32 43 panhypopituitarism nos (disorder) 6 panhypopituitarism (disorder) 6

simmonds' disease 6 simmond's disease 6 sheehan syndrome 43

Diseases related to panhypopituitarism by text searches and GeneDecks gene sharing:

(show top 50)    (show all 337)

id	Related Disease	Score	Top Affiliating Genes
1	panhypopituitarism x-linked	31.4	SOX3, HDX
2	sheehan syndrome	27.9	IGF1, PRL, POMC
3	diabetes insipidus	27.2	S100B, AVP, IGF1, CALCA, PRL, POMC
4	combined pituitary hormone deficiency	27.0	LHX3, LHX4, IGF1, GH1, HESX1, TSHB
5	pituitary hypoplasia	26.4	LHX3, LHX4, GH1, HESX1, PRL, PROP1
6	thalassemia	25.9	BGLAP, IGF1, ALPP, CALCA, GH1, GHRL
7	hypopituitarism	24.5	LHX3, LHX4, AVP, IGF1, GH1, GHR
8	craniopharyngioma	24.4	AVP, IGF1, CALCA, GH1, GHRL, ELANE
9	pancreatitis	21.1	BGLAP, S100B, IGFBP1, IGF2, IGF1, ALPP
10	prostatitis	20.2	BGLAP, S100B, IGFBP1, IGF2, IGF1, ALPP
11	breast cancer	19.6	BGLAP, S100B, AVP, IGFBP1, IGF2, IGF1
12	growth hormone deficient dwarfism	13.6	GH1, POU1F1
13	neonatal thyrotoxicosis	13.5	LHX3, PROP1
14	tsh producing pituitary tumor	13.5	GH1, PRL
15	chromophobe adenoma	13.5	GH1, PRL
16	insulin-like growth factor i deficiency	13.5	IGF1, GHR
17	adrenal gland hyperfunction	13.4	AVP, PRL
18	mccune albright syndrome	13.4	GH1, PRL
19	inappropriate adh syndrome	13.4	AVP, POMC
20	hypothalamic disease	13.4	GH1, PRL
21	kallmann syndrome	13.4	LHX3, HESX1, PROP1
22	prolactin producing pituitary tumor	13.4	PRL, POMC
23	robinow syndrome	13.4	IGF1, GH1
24	obstructive hydrocephalus	13.4	IGF1, PRL
25	empty sella syndrome	13.4	PRL, POMC
26	x-linked hypophosphatemia	13.4	BGLAP, GH1
27	gonadotropin deficiency	13.3	GH1, HESX1, PRL
28	rabson-mendenhall syndrome	13.3	IGF1, GH1
29	cushing's syndrome	13.3	GH1, POMC
30	isolated acth deficiency	13.3	PRL, POMC
31	neurogenic diabetes insipidus	13.3	AVP, PRL, POMC
32	laron dwarfism	13.3	IGF1, GH1, GHR
33	pituitary-dependent cushing's disease	13.3	GH1, PRL, POMC
34	gonadal disease	13.3	IGF1, GH1, POMC
35	pituitary gland disease	13.2	IGF1, GH1, PRL
36	pseudohypoparathyroidism type ia	13.2	IGF1, GH1, PRL
37	melancholia	13.2	PRL, POMC
38	hypertrichosis	13.2	IGF1, PRL, SOX3
39	somatotrophinoma	13.2	IGF1, GH1, PRL
40	nelson syndrome	13.2	PRL, POMC
41	carney complex	13.2	GH1, PRL, POMC
42	paget's disease of bone	13.2	BGLAP, CALCA
43	acanthosis nigricans	13.2	IGF1, GH1, PRL
44	delayed puberty	13.2	IGF1, GHR, PRL
45	germinoma	13.2	AVP, ALPP, PRL
46	gastrinoma	13.1	IGF1, GH1, POMC
47	penis paget's disease	13.1	KLK3, PRL
48	hypoadrenalism	13.1	CALCA, GH1, POMC
49	idiopathic juvenile osteoporosis	13.1	BGLAP, CALCA
50	noonan syndrome	13.1	IGF1, GH1, GHR

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to panhypopituitarism:

²²

MGI Mouse Phenotypes related to panhypopituitarism:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.0	LHX3, POU1F1, SOX3, PROP1, HESX1, SMPD3
2	reproductive system phenotype	MP:0005389	8.6	POU1F1, SOX3, PROP1, PRL, SMPD3, GH1
3	growth/size phenotype	MP:0005378	8.5	SOX3, PROP1, SMPD3, GHR, GH1, ALPP
4	mortality/aging	MP:0010768	8.0	POU1F1, SOX3, PROP1, HESX1, ELANE, SMPD3
5	behavior/neurological phenotype	MP:0005386	6.6	PRL, PROP1, SOX3, POMC, GHRL, GHR
6	nervous system phenotype	MP:0003631	6.4	HESX1, PRL, PROP1, SOX3, POMC, POU1F1
7	homeostasis/metabolism phenotype	MP:0005376	5.4	SMPD3, ELANE, PRL, PROP1, SOX3, POMC

Articles related to panhypopituitarism:

(show all 15)

id	Title	Authors	Year	Affiliating Genes
1	Magnetic resonance imaging and pituitary function in children with panhypopituitarism. (20197674)	Li G.... Zhang L.	2010	IGF1, POMC, GH1
2	Acute pancreatitis in a girl with panhypopituitarism due to craniopharyngioma on growth hormone treatment. A combination of risk fac tors. (19506396)	Faienza M.F.... Cavallo L.	2009	ELANE, GHRL
3	Panhypopituitarism due to metastases to the hypothala mus and the pituitary resulting from primary breast cancer: a case report and r eview of the literature. (19933072)	Peppa M.... Hadjidakis D.	2009	PRL
4	An adolescent boy with thalassemia major presenting with bone pain, numbness, tetanic contractions and growth and pubertal delay: panhypopituitarism and combined vitamin D and parathyroid defects. (19337171)	Soliman A.... Wagdy M.	2008	ALPP
5	Association of low prostate-specific antigen concentration and panhypopituitarism. (18558595)	Drincic A.... Baltaro R.	2008	KLK3
6	Panhypopituitarism: genetic versus acquired etiological factors. (17315526)	Coya R.... Martul P.	2007	PROP1, HESX1
7	Worster-Drought syndrome (congenital bilateral perisylvian syndrome) with posterior pituitary ectopia, pituitary hypoplasia, empty sella and panhypopituitarism: a patient report. (16759040)	BaA9 F.... GA1nAPz H.	2006	POMC
8	Primary hypothalamic lymphoma with panhypopituitarism presenting as stiff-man syndrome. (15311173)	Lee M.T.... Tang K.T.	2004	PRL
9	Virus encephalitis with symptomatic Parkinson syndrome, diabetes insipidus and panhypopituitarism (10596369)	Ickenstein G.W.... Langohr H.D.	1999	PRL, AVP
10	Evolution of childhood central diabetes insipidus into panhypopituitarism with a large hypothalamic mass: is 'lymphocytic infundibuloneurohypophysitis' in children a different entity? (9916870)	Maghnie M.... Severi F.	1998	S100B
11	X-linked recessive panhypopituitarism associated with a regional duplication in Xq25-q26. (9106538)	Lagerstrom-Fermer M.... Pettersson U.	1997	SOX3
12	Bone turnover and bone mineral density in young adult patients with panhypopituitarism before and after long-term growth hormone therapy. (7850009)	Balducci R.... Boscherini B.	1995	IGF1, CALCA, BGLAP
13	Serum growth hormone-binding protein is unchanged in adult panhypopituitarism. (7962328)	Davila N.... Baumann G.	1994	GHR, GH1
14	Potent effect of recombinant growth hormone on bone mineral density and body composition in adults with panhypopituitarism. (1621480)	Degerblad M.... ThorAcn M.	1992	IGF2, IGFBP1
15	Long-term opiate receptor antagonism in a patient with panhypopituitarism: effects on appetite, prolactin and demand for vasopressin. (2045062)	Kraft K.... Vetter H.	1991	PRL

Genes related to panhypopituitarism according to GeneCards:

(show all 24)

id	Symbol	Description	Score	GeneCards Section Context
1	SOX3	SRY (sex determining region Y)-box 3	11.1	Aliases & Descriptions, Publications
2	HDX	highly divergent homeobox	11.0
3	HESX1	HESX homeobox 1	11.0	Publications
4	PROP1	PROP paired-like homeobox 1	11.0	Publications
5	LHX3	LIM homeobox 3	11.0
6	TSHB	thyroid stimulating hormone, beta	11.0
7	LHX4	LIM homeobox 4	11.0
8	AVP	arginine vasopressin	11.0	Publications
9	POU1F1	POU class 1 homeobox 1	11.0
10	SMPD3	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	11.0
11	POMC	proopiomelanocortin	11.0	Publications
12	PRL	prolactin	11.0	Publications
13	GH1	growth hormone 1	11.0	Publications
14	GHR	growth hormone receptor	11.0	Publications
15	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
16	IGFBP1	insulin-like growth factor binding protein 1	11.0	Publications
17	S100B	S100 calcium binding protein B	11.0	Publications
18	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
19	ALPP	alkaline phosphatase, placental	11.0	Publications
20	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
21	ELANE	elastase, neutrophil expressed	11.0	Publications
22	GHRL	ghrelin/obestatin prepropeptide	11.0	Publications
23	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Publications
24	KLK3	kallikrein-related peptidase 3	11.0	Publications

Pathways related to panhypopituitarism according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	G alpha (s) signalling events38	10.0	AVP, TSHB, POMC
2	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.4	BGLAP, IGF1, CALCA
3	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.2	BGLAP, IGF1, CALCA
4	Growth Hormone Signaling36	9.0	IGF2, IGF1, GH1, GHR
5	Cell adhesion ECM remodeling10	8.8	KLK3, IGF1, IGF2
6	Disease38	8.7	PRL, KLK3, IGF1, IGF2
7	JAK-STAT Pathway36	8.5	PRL, GHR, GH1, IGF1, IGF2
8	Cell adhesion_ECM remodeling41	8.5	IGF1, IGF2, KLK3

Compounds related to panhypopituitarism according to GeneDecks:

(show top 50)    (show all 141)

id	Compound	Score	Top Affiliating Genes
1	estradiol32 9 18 9	13.0	IGFBP1, PRL, POMC
2	deoxypyridinoline32	9.2	IGF1, ALPP, IGFBP1, GH1, BGLAP
3	leuprolide acetate32	9.2	PRL, KLK3, IGF1, GHR, GH1
4	ghrp32	9.1	GHR, GH1, GHRL, PRL, IGF1
5	dopamine32 9 18 9	12.1	GH1, POU1F1, S100B, GHRL
6	pyridostigmine32 9 9	11.0	IGF1, GH1, GHRL, PRL, IGFBP1
7	lanreotide32	8.9	GH1, GHR, KLK3, PRL, IGF1, IGFBP1
8	buserelin32 9 9	10.9	IGFBP1, PRL, KLK3, CALCA, IGF1
9	c-peptide32	8.9	IGF2, GHR, GHRL
10	hexarelin32	8.9	GH1, IGF1, PRL, GHR, POMC, GHRL
11	pyridinoline32	8.9	BGLAP, IGF1, ALPP, CALCA, GH1
12	clonidine32 9 9	10.7	IGF1, CALCA, BGLAP, GHR, PRL, POMC
13	creatinine32	8.5	POMC, S100B, IGFBP1, IGF1, GHRL, GHR
14	alendronate32 9 9	10.5	BGLAP, ALPP, IGF1, CALCA, KLK3, GH1
15	bromocriptine32 9 9	10.5	IGF2, IGF1, GH1, GHR, PRL, POMC
16	epinephrine32 9 18 9	11.5	KLK3, GHRL, POMC, IGFBP1, ELANE
17	1,25 dihydroxy vitamin d332	8.4	POU1F1, ALPP, GH1, CALCA, BGLAP, IGF1
18	gnrh32	8.3	HESX1, PROP1, POMC, GHRL, GHR, LHX3
19	androstenedione32 18	9.3	IGF2, IGFBP1, IGF1, GH1, GHR, PRL
20	pegvisomant32 9 9	10.3	IGFBP1, IGF2, GHRL, GHR, GH1, IGF1
21	progestin32	8.1	PRL, ALPP, IGF1, IGF2, IGFBP1, POMC
22	2-deoxyglucose32	8.0	IGFBP1, IGF2, GHRL, IGF1, POMC, CALCA
23	estrone32 9 18 9	10.8	PRL, GH1, IGF1, IGF2, BGLAP, IGFBP1
24	dihydrotestosterone32 9 18 9	10.7	GH1, PRL, KLK3, IGFBP1, IGF1, IGF2
25	triiodothyronine32	7.6	IGF2, IGFBP1, IGF1, GH1, GHR, POMC
26	chloramphenicol32 9 9	9.6	ELANE, GHR, ALPP, IGF2, IGFBP1, TSHB
27	tamoxifen32 34 9 9	10.6	IGF2, ALPP, GH1, BGLAP, IGFBP1, GHR
28	dhea32	7.5	IGFBP1, GHRL, GH1, IGF1, KLK3, PRL
29	corticosterone32 18	8.5	BGLAP, IGFBP1, GH1, GHRL, PRL, IGF2
30	ribonucleic acid32	7.4	IGF2, IGFBP1, IGF1, POU1F1, GH1, GHR
31	dehydroepiandrosterone sulfate32	7.3	IGF2, IGFBP1, IGF1, GH1, GHR, POMC
32	testosterone32 9 18 9	10.2	BGLAP, S100B, IGFBP1, ALPP, GHR, ELANE
33	calcitriol32 42 9 18 9	11.1	GH1, CALCA, IGF2, ALPP, GHR, IGFBP1
34	thymidine32 18	8.0	ALPP, POU1F1, S100B, IGFBP1, IGF1, GH1
35	steroid32	6.9	GH1, S100B, AVP, IGFBP1, IGF2, IGF1
36	paraffin32	6.8	KLK3, IGF2, S100B, POMC, GHRL, BGLAP
37	octreotide32 42 9 9	9.8	POMC, PRL, ELANE, GHRL, GHR, GH1
38	alanine32	6.5	POU1F1, POMC, SOX3, BGLAP, S100B, AVP
39	norepinephrine32 9 18 9	9.4	CALCA, S100B, AVP, IGFBP1, IGF2, ALPP
40	retinoic acid32 42 18	8.3	TSHB, ELANE, S100B, GHR, GH1, ALPP
41	lactate32	6.3	IGF2, GHRL, KLK3, ELANE, CALCA, ALPP
42	arginine32	6.2	GH1, IGF1, GHR, IGF2, IGFBP1, AVP
43	vegf32	6.1	GH1, IGF2, BGLAP, S100B, IGF1, ALPP
44	acth32	6.0	POU1F1, POMC, PROP1, PRL, TSHB, HESX1
45	hydrocortisone32 9 9	7.8	POMC, PRL, ELANE, KLK3, GHRL, GH1
46	vitamin d32	5.8	POU1F1, ELANE, KLK3, GHRL, GHR, GH1
47	dexamethasone32 42 34 9 9	9.7	IGF2, GHR, GHRL, KLK3, PRL, BGLAP
48	serine32	5.3	PROP1, ELANE, KLK3, S100B, BGLAP, IGF1
49	thyroxine32 18	6.3	POMC, PRL, TSHB, ELANE, KLK3, GHRL
50	estrogen32	4.8	POU1F1, KLK3, GHRL, POMC, PRL, ELANE

Cellular components related to panhypopituitarism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule	GO:030141	8.9	AVP, GHRL, ELANE, POMC
2	extracellular space	GO:005615	6.3	POMC, GHRL, GHR, GH1, CALCA, IGF1
3	extracellular region	GO:005576	4.6	BGLAP, POMC, PRL, TSHB, ELANE, KLK3

Biological processes related to panhypopituitarism according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	medial motor column neuron differentiation	GO:021526	10.2	LHX3, LHX4
2	negative regulation of release of cytochrome c from mitochondria	GO:090201	10.0	AVP, IGF1
3	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	9.8	PRL, GHR, GH1
4	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.8	GHR, GH1, IGF1
5	regulation of multicellular organism growth	GO:040014	9.6	PRL, GHR, IGF1
6	growth hormone receptor signaling pathway	GO:060396	9.6	GH1, GHR
7	positive regulation of multicellular organism growth	GO:040018	9.4	GHRL, GHR, GH1
8	response to estrogen stimulus	GO:043627	9.2	BGLAP, GHRL, TSHB
9	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.0	IGF2, IGF1, GH1, GHR

Molecular functions related to panhypopituitarism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	prolactin receptor binding	GO:005148	10.0	GH1, PRL
2	hormone activity	GO:005179	7.6	IGF2, IGF1, CALCA, GH1, TSHB, PRL