MCID: PNH001
MIFTS: 55

Panhypopituitarism malady

Summaries for Panhypopituitarism

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced... more...

MalaCards: Panhypopituitarism, also known as panhypopituitarism nos, is related to diabetes insipidus and empty sella syndrome. An important gene associated with Panhypopituitarism is SOX3 (SRY (sex determining region Y)-box 3), and among its related pathways are Glucocorticoid receptor regulatory network and Insulin Processing. The compounds estrogen and dopamine have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and lung, and related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Aliases & Classifications for Panhypopituitarism

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

panhypopituitarism 8 44 60
panhypopituitarism nos 8
simmond's disease 8
simmonds' disease 8


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Disease Ontology8 DOID:9410
MeSH34 D007018
ICD9CM27 253.2

Related Diseases for Panhypopituitarism

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17GeneCards, 18GeneDecks
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Diseases related to Panhypopituitarism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus30.8AVP, POMC, PRL
2empty sella syndrome30.3POMC, PRL
3pituitary apoplexy30.2PRL, POMC
4craniopharyngioma30.2PRL, PROP1, IGF1, POMC, AVP, GH1
5hypothyroidism30.2TSHB, AVP, POMC, POU1F1, IGF1, PROP1
6cushing's syndrome30.2POMC, GH1
7breast cancer30.1POU1F1, IGFBP1, ALPP, GH1, IGF1, CALCA
8chromophobe adenoma30.1PRL, GH1
9meningitis30.1AVP
10thyroiditis30.1POMC, CALCA
11hypogonadism30.0POMC, POU1F1, IGF1, PROP1, PRL, GH1
12hypogonadotropism29.9PRL
13lung cancer29.9IGF1, POMC
14acromegaly29.9IGF1, GH1, PRL
15sheehan syndrome29.9IGF1, PRL, POMC
16pituitary hypoplasia29.9POU1F1, PROP1, LHX4, SOX3, LHX3, HESX1
17leukemia29.9IGFBP1, ALPP, GHR
18lung small cell carcinoma29.9CALCA, SOX3, POMC, AVP
19arthritis29.9POMC, ALPP, CALCA, GHRL
20hyperthyroidism29.9TSHB, ALPP, IGF1, GH1, GHRL, GHR
21diabetes mellitus29.9ALPP, POMC, IGF1, CALCA, GHR, GHRL
22hypopituitarism29.9PROP1, LHX3, HESX1, LHX4, GH1, PRL
23nephrotic syndrome29.7POMC
24systemic lupus erythematosus29.7PRL
25histiocytosis29.7S100B
26cholestasis29.7ALPP
27rheumatoid arthritis29.7GHRL
28pancreatitis29.7ALPP
29pituitary cancer29.7POMC, PRL
30thyroid cancer29.7CALCA
31infertility29.7IGFBP1, PRL
32cryptorchidism29.7ALPP
33myocardial infarction29.7IGFBP1, GHRL
34amenorrhea29.7PRL, IGF1, POMC
35osteoporosis29.7CALCA, GHR, GH1, IGF1, ALPP
36anorexia nervosa29.7IGF1, POMC, GHR, GHRL, PRL, GH1
37obesity29.7HESX1, GHR, GH1, IGFBP1, PROP1, IGF1
38pituitary adenoma29.7POU1F1, GHR, IGF1, PROP1, PRL, GH1
39adenoma29.7CALCA, GHR, TSHB, POMC, POU1F1, IGF1
40addison's disease10.2
41panhypopituitarism x-linked10.1
42progeria10.1
43paraplegia10.1
44central nervous system lymphoma10.1
45cleft palate10.1
46hodgkin's lymphoma10.1
47congestive heart failure10.0AVP
48panic disorder10.0POMC
49nephrogenic diabetes insipidus10.0AVP
50adrenocortical carcinoma10.0POMC

Graphical network of the top 20 diseases related to Panhypopituitarism:



Diseases related to panhypopituitarism

Clinical Features for Panhypopituitarism

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Drugs & Therapeutics for Panhypopituitarism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Panhypopituitarism

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Anatomical Context for Panhypopituitarism

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32MalaCards
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MalaCards organs/tissues related to Panhypopituitarism:

32
Pituitary, Brain, Lung, Bone, Breast, Thyroid, Liver, Heart, Prostate, Hypothalamus, Pineal, B cells, Myeloid, Testes, Bone marrow

Animal Models for Panhypopituitarism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Panhypopituitarism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.5POU1F1, PROP1, GHR, SOX3, HESX1, LHX3
2MP:00053759.1POMC, IGF1, GH1, GHRL, GHR
3MP:00028738.2CALCA, S100B, HESX1, GHRL, HDX, IGF1
4MP:00053897.9LHX3, SOX3, GHR, GH1, PRL, PROP1
5MP:00053867.9CALCA, S100B, SOX3, GHR, GHRL, PRL
6MP:00053787.7LHX3, SOX3, GHR, GH1, PROP1, IGF1
7MP:00036317.3GHR, SOX3, HESX1, CALCA, LHX3, LHX4
8MP:00107687.2SOX3, HESX1, CALCA, LHX3, LHX4, GHR
9MP:00053767.1GHRL, GHR, SOX3, CALCA, LHX3, LHX4

Publications for Panhypopituitarism

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50PubMed
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Articles related to Panhypopituitarism:

(show top 50)    (show all 289)
idTitleAuthorsYear
1
Morning glory syndrome associated with transsphenoidal encephalocele and panhypopituitarism. (24418230)
2014
2
Acute myeloid leukemia presenting with panhypopituitarism or diabetes insipidus: a case series with molecular genetic analysis and review of the literature. (24286261)
2013
3
Reversible panhypopituitarism in a patient with Cushing's syndrome secondry to ectopic-adrenocorticotropic hormone producing small cell lung carcinoma. (24365756)
2013
4
Dobrava hantavirus infection complicated by panhypopituitarism, Istanbul, Turkey, 2010. (22709722)
2012
5
Primary antiphospholipid syndrome and panhypopituitarism: a unique presentation. (23348118)
2012
6
Esophageal achalasia with panhypopituitarism: a rare association. (21342335)
2011
7
Isolated sellar tuberculoma presenting with panhypopituitarism: clinical, diagnostic considerations and literature review. (20886253)
2011
8
Response to growth hormone therapy in adolescents with familial panhypopituitarism. (20431169)
2010
9
Acute coronary syndrome mimicking atypical stress-induced cardiomyopathy in a patient with panhypopituitarism. (20661331)
2010
10
A case of cocaine-induced panhypopituitarism with human neutrophil elastase-specific anti-neutrophil cytoplasmic antibodies. (19114541)
2009
11
An adolescent boy with thalassemia major presenting with bone pain, numbness, tetanic contractions and growth and pubertal delay: panhypopituitarism and combined vitamin D and parathyroid defects. (19337171)
2008
12
Panhypopituitarism as first manifestation of a lung cancer. (17272231)
2007
13
Idiopathic hypertrophic pachymeningitis resulting in delayed panhypopituitarism. (17872350)
2007
14
An elderly patient with sarcoidosis manifesting panhypopituitarism with central diabetes insipidus. (17446653)
2007
15
Worster-Drought syndrome (congenital bilateral perisylvian syndrome) with posterior pituitary ectopia, pituitary hypoplasia, empty sella and panhypopituitarism: a patient report. (16759040)
2006
16
Mycobacterium avium complex lung disease and panhypopituitarism. (16007905)
2005
17
Panhypopituitarism and hydrocephalus with cerebrospinal fluid shunting following total hypophysectomy: case report of a successful pregnancy. (16147702)
2005
18
Intracranial aggressive fibromatosis presenting as panhypopituitarism and diabetes insipidus. (16379037)
2005
19
Acute chagas' disease presenting with a suprasellar mass and panhypopituitarism. (15761661)
2004
20
Complications of malignancy: case 3. Chronic lymphocytic leukemia presenting with panhypopituitarism. (14722047)
2004
21
A case of Sheehan's syndrome with panhypopituitarism due to the impairment of both the hypothalamus and the pituitary. (14599115)
2003
22
Panhypopituitarism due to pituitary cyst of Rathke's cleft origin--two case reports. (11817298)
2001
23
Why is the retention of gonadotrophin secretion common in children with panhypopituitarism due to septo-optic dysplasia? (10037251)
1999
24
Panhypopituitarism. (12024385)
1999
25
BehAset's disease with gastrointestinal involvement associated with myelodysplasia in a patient with congenital panhypopituitarism. (9890682)
1998
26
Effect of growth hormone on fatty liver in panhypopituitarism. (9245856)
1997
27
Panhypopituitarism as a consequence of metastase of breast cancer in sella turcica. (8784867)
1996
28
Pituitary apoplexy followed by panhypopituitarism presenting as a psychiatric disorder. (8775543)
1996
29
Male pseudohermaphroditism secondary to panhypopituitarism. (8869199)
1996
30
Panhypopituitarism in two cirrhotics: clinical presentation and liver disease associations. (7650565)
1995
31
Bone turnover and bone mineral density in young adult patients with panhypopituitarism before and after long-term growth hormone therapy. (7850009)
1995
32
Congenital panhypopituitarism of late onset. (8077619)
1994
33
Neonatal-onset panhypopituitarism in a girl with Brachmann-De Lange syndrome. (2333897)
1990
34
Infundibular metastasis and panhypopituitarism. (2540336)
1989
35
Case report: idiopathic giant cell granuloma of the hypophysis: an unusual cause of panhypopituitarism. (2734692)
1989
36
Renal effects of amino acid infusions in patients with panhypopituitarism. (3384471)
1988
37
Reversible panhypopituitarism due to Cushing's syndrome. (3377619)
1988
38
Primary empty sella syndrome with panhypopituitarism in a child. (6543857)
1984
39
Reversible panhypopituitarism caused by a suprasellar aneurysm: the contribution of mass effect to pituitary dysfunction. (6808414)
1982
40
A case of histiocytosis X associated with panhypopituitarism and hyperimmunoglobulinemia G and E. (225167)
1979
41
Nocturnal diuresis in panhypopituitarism. (682967)
1978
42
Panhypopituitarism, chronic renal failure and osteomalacia. (5483312)
1970
43
CORTICOSTEROID-INDUCED ATROPHY OF THE HUMAN ADRENALS COMPARABLE TO PANHYPOPITUITARISM; A HISTOPATHOLOGICAL STUDY. (14222347)
1964
44
Hypothalamic angioma with panhypopituitarism. (13929260)
1962
45
Sheehan's syndrome (postpartum panhypopituitarism). (13646936)
1959
46
Panhypopituitarism due to ectopic pinealoma; a clinical-pathological conference. (14358990)
1955
47
Clinical observations on panhypopituitarism. (13246794)
1955
48
The use of cortisone in the treatment of the panhypopituitarism due to postpartum necrosis of the pituitary (Sheehan's syndrome). (13116420)
1954
49
The variability of the lowered glomerular filtration rate in Addison's disease and panhypopituitarism, and the effect of cortisone thereon. (14936287)
1952
50
Panhypopituitarism treated by homotransplantation. (13018361)
1952

Genetic Variations for Panhypopituitarism

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Expression for genes affiliated with Panhypopituitarism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Panhypopituitarism

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Pathways for genes affiliated with Panhypopituitarism

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37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Panhypopituitarism

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Panhypopituitarism according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7TSHB
2dopamine44 28 11 2413.0GHRL, GHR, IGF1
3estradiol44 11 2411.9POMC, GHR, PRL
4bromocriptine28 44 1111.9POU1F1, POMC, PRL, GHR
5deoxypyridinoline449.9GH1, IGFBP1, CALCA
6dehydroepiandrosterone sulfate449.9IGFBP1, GH1, POMC, GHR
7forskolin44 49 1111.8CALCA, POMC, POU1F1
8leuprolide acetate449.8PRL, GH1, GHR, IGF1
9naltrexone44 49 28 1112.7GH1, IGF1, POMC, PRL
10clomiphene citrate449.6GH1, PRL, IGFBP1, IGF1
11ether449.6POMC, CALCA, GHRL, AVP
12cabergoline28 44 1111.6PRL, IGF1, GHR, GH1
13quinagolide449.6GH1, IGF1, PRL
14pirenzepine44 28 1111.6GHRL, IGF1, IGFBP1, GH1
15buserelin44 28 1111.6IGFBP1, CALCA, IGF1, PRL
16lanreotide44 2810.5IGF1, IGFBP1, GH1, GHR, PRL
17ghrp449.5GH1, GHR, IGF1, GHRL, PRL
18pyridostigmine44 1110.4GHRL, IGFBP1, IGF1, GH1, PRL
19pegvisomant44 1110.4GHR, GHRL, IGF1, GH1, IGFBP1
20metformin44 49 1111.4GH1, GHRL, IGFBP1, IGF1, POMC
21c-peptide449.3IGF1, IGFBP1, GH1, GHRL, GHR
22hexarelin44 2810.3PRL, IGF1, GHRL, POMC, GHR, GH1
23pyridinoline449.3CALCA, ALPP, IGF1, GH1
242-deoxyglucose44 1110.2GHRL, POMC, CALCA, IGF1, IGFBP1
25androstenedione44 2410.2IGF1, POMC, IGFBP1, PRL, GH1, GHR
26clonidine44 28 1111.2POMC, PRL, IGF1, CALCA, GHR, GH1
27gnrh449.2LHX3, HESX1, GHR, GHRL, GH1, PROP1
28dhea449.2POMC, IGF1, IGFBP1, PRL, GHRL, GH1
29glucose449.1GHRL, POMC, AVP, IGF1
30norepinephrine44 11 2411.1CALCA, S100B, PRL, POMC, ALPP, AVP
31corticosterone44 59 2411.1IGFBP1, POMC, PRL, GHRL, GH1, CALCA
32progestin449.0IGF1, IGFBP1, PRL, POMC, ALPP
33creatinine448.8POMC, IGF1, ALPP, AVP, GHR, IGFBP1
34triiodothyronine448.8POMC, TSHB, IGF1, IGFBP1, PRL, GH1
35calcitriol44 59 11 2411.8IGF1, GHR, CALCA, GH1, IGFBP1, ALPP
36alanine448.7SOX3, GHRL, GH1, POU1F1, POMC, ALPP
37epinephrine44 11 2410.7POMC, IGFBP1, GH1, GHRL, CALCA, PRL
38chloramphenicol44 2 1110.7GHR, GH1, TSHB, ALPP, IGFBP1, S100B
39progesterone44 59 28 11 2412.6S100B, GHR, GH1, PRL, IGFBP1, IGF1
40octreotide44 59 28 1111.6POMC, CALCA, GHRL, GH1, PRL, IGFBP1
41ribonucleic acid448.6TSHB, POMC, IGF1, IGFBP1, PRL, GH1
42steroid448.4IGFBP1, PROP1, GH1, GHR, S100B, POU1F1
43hydrocortisone44 2 59 1111.4ALPP, CALCA, POMC, IGF1, IGFBP1, PRL
44vitamin d448.4GHRL, GHR, IGFBP1, CALCA, GH1, ALPP
45thymidine44 249.2IGF1, GH1, GHRL, GHR, S100B, IGFBP1
46thyroxine44 249.0GH1, PRL, IGFBP1, GHRL, IGF1, GHR
47dexamethasone44 49 28 1110.8ALPP, GHR, S100B, AVP, POMC, POU1F1
48arginine447.8IGFBP1, IGF1, POU1F1, POMC, ALPP, PRL
49acth447.8GHR, S100B, POU1F1, HESX1, TSHB, GHRL
50testosterone44 59 11 2410.7ALPP, POMC, IGF1, PRL, CALCA, S100B

GO Terms for genes affiliated with Panhypopituitarism

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16Gene Ontology
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Cellular components related to Panhypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.9POMC, GHRL
2secretory granuleGO:0301419.5AVP, POMC, PRL
3extracellular spaceGO:0056157.8CALCA, S100B, GHR, GHRL, GH1, IGFBP1
4extracellular regionGO:0055767.5TSHB, CALCA, S100B, GHR, GHRL, GH1

Biological processes related to Panhypopituitarism according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1medial motor column neuron differentiationGO:02152610.3LHX3, LHX4
2growth hormone receptor signaling pathwayGO:06039610.2GH1, GHR
3organ morphogenesisGO:00988710.0LHX4, LHX3, SOX3
4negative regulation of release of cytochrome c from mitochondriaGO:09020110.0AVP, IGF1
5positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.0IGF1, GH1
6JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.0PRL, GH1, GHR
7positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.0GHR, GH1, IGF1
8response to estradiol stimulusGO:03235510.0PRL, GH1, GHR
9regulation of multicellular organism growthGO:04001410.0GHR, PRL, IGF1
10insulin-like growth factor receptor signaling pathwayGO:0480099.9IGF1, GHR
11positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.9GHR, GH1, IGF1
12positive regulation of JAK-STAT cascadeGO:0464279.9GH1, PRL
13positive regulation of multicellular organism growthGO:0400189.7POU1F1, GH1, GHRL, GHR
14cell-cell signalingGO:0072679.7TSHB, AVP, POMC, CALCA
15negative regulation of apoptotic processGO:0430669.6LHX4, LHX3, GHRL, PROP1, AVP
16cellular protein metabolic processGO:0442679.3GHRL, IGFBP1, IGF1, POMC, TSHB
17elevation of cytosolic calcium ion concentrationGO:0072049.3AVP, GHRL, CALCA

Molecular functions related to Panhypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:0051489.9PRL, GH1
2sequence-specific DNA binding transcription factor activityGO:0037009.3POU1F1, PROP1, HDX, HESX1, LHX3, LHX4
3sequence-specific DNA bindingGO:0435659.2LHX4, LHX3, HESX1, HDX, POU1F1
4hormone activityGO:0051798.9TSHB, CALCA, GH1, PRL, IGF1, POMC

Products for genes affiliated with Panhypopituitarism

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Sources for Panhypopituitarism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet