Panic Disorder malady

MedlinePlus: Panic disorder is an anxiety disorder. it causes panic attacks, which are sudden feelings of terror for no reason. you may also feel physical symptoms, such as fast heartbeat chest pain breathing difficulty dizziness panic attacks can happen anytime, anywhere and without warning. you may live in fear of another attack and may avoid places where you have had an attack. for some people, fear takes over their lives and they cannot leave their homes. panic disorder is more common in women than men. it usually starts when people are young adults. sometimes it starts when a person is under a lot of stress. most people get better with treatment. therapy can show you how to recognize and change your thinking patterns before they lead to panic. medicines can also help. nih: national institute of mental health²³

MalaCards: Panic Disorder, also known as panic disorder syndrome, is related to social phobia and schizophrenia. An important gene associated with Panic Disorder is PAND2 (panic disorder 2), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. The drugs paroxetine and imipramine hydrochloride and the compounds nicotine and paroxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Disease Ontology: An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.⁶

Wikipedia: Panic disorder is an anxiety disorder characterized by recurring severe panic attacks. It may also...⁴⁴ more...

OMIM: 167870

Aliases & Descriptions:

panic disorder 6 7 33 32 23 43 panic disorder syndrome 7 panic anxiety syndrome 6

panic disorder 1 43 panic disease 8 panic 32

Disease types for panic disorder family:

panic disorder syndrome 1	panic disorder 3
panic disorder 2

Diseases related to panic disorder by text searches and GeneDecks gene sharing:

(show top 50)    (show all 594)

id	Related Disease	Score	Top Affiliating Genes
1	social phobia	31.8	MAOA, HTR1A, HTR3A, DRD2, COMT, SLC6A4
2	schizophrenia	31.8	MAOA, HTR2A, DRD2, DRD3, DAOA, NOS1
3	agoraphobia	31.7	NAGLU, MAOA, CCKBR, HTR1A, PTK7, SLC6A2
4	anxiety disorder	31.5	BDNF, MAOA, CCKBR, CCK, HTR1A, HTR2A
5	bipolar disorder	31.1	BDNF, HTR1A, SLC6A4
6	phobia	30.4	MAOA, CCK, HTR1A, HTR3A, CAT, DRD2
7	generalized anxiety disorder	29.9	HTR1A, TSPO, SLC6A4
8	insomnia	29.4	HTR1A, HTR2A, HTR2C, HTR3A, CAT, GHRL
9	alexithymia	29.1	CRP, COMT, TTF2, SLC6A4
10	hypertension	29.0	ACE, AGT, AGTR1, RGS2
11	attention deficit hyperactivity disorder	28.9	BDNF, CHRNA4, MAOA, HTR1B, HTR2A, HTR2C
12	migraine without aura	27.5	ESR1, CRP, NOS1, ACE
13	irritable bowel syndrome	27.0	IL10, CCK, CCKAR, HTR1A, HTR2A, HTR3A
14	obsessive-compulsive disorder	26.7	BDNF, APOE, MAOA, CCKBR, CCK, HTR1A
15	major depressive disorder	24.3	PDE4B, BDNF, IL10, IL19, APOE, MAOA
16	essential hypertension	20.8	NAGLU, CLU, XDH, AVPR1A, IL10, APOE
17	blindness	20.2	CLU, SDK2, XDH, IL10, APOE, MAOA
18	neuronitis	16.7	PDE4B, CLU, BDNF, SDK2, CHRNA4, LDHA
19	cerebritis	15.3	NAGLU, BDNF, CHRNA4, XDH, AVP, GRM7
20	endogenous depression	14.1	MAOA, TRH, CRH, SLC6A4
21	conduct disorder	13.9	MAOA, HTR1B, SLC6A4
22	amnestic disorder	13.9	AVP, HTR1A, HTR3A, PTK7, POMC
23	conduction disease	13.9	MAOA, DRD4, DRD5, SLC6A4
24	motion sickness	13.9	AVP, HTR1A, HTR3A, TAC1
25	major affective disorder	13.9	HTR2A, HTR3A, TPH1, ACE
26	anxiety-related personality traits	13.8	BDNF, COMT, SLC6A4
27	bulimia nervosa	13.8	CCK, GHRL, SLC6A4
28	gilles de la tourette syndrome	13.8	HTR3A, DRD2, DRD4, DRD5, COMT, TTF2
29	adrenocorticotropic hormone deficiency	13.8	GHRH, CRH, POMC
30	tic disorder	13.8	HTR2A, DRD2, DRD4
31	antisocial personality disorder	13.8	MAOA, HTR1B, HTR2A, DRD2, DRD4, SLC6A4
32	tremor	13.8	CCK, IGKV2D-29, HTR2A, HTR2C, HTR3A, TPH1
33	opiate dependence	13.8	MAOA, DRD2, COMT, SLC6A4
34	gastrointestinal system disease	13.8	CCKBR, CCK, CCKAR, GHRL, TPH1, NTRK3
35	novelty seeking personality	13.7	MAOA, DRD2, DRD4, COMT, ACE, SLC6A2
36	neuroleptic malignant syndrome	13.7	HTR1A, HTR2A, HTR3A, DRD2, POMC
37	morphine dependence	13.7	CCKBR, CCK, NOS1, ADORA1
38	temporal lobe epilepsy	13.7	BDNF, HTR1A, TSPO, NPY, ADORA1, GAD2
39	borderline personality disorder	13.7	MAOA, HTR1B, TRH, TPH1, COMT, PRL
40	postpartum depression	13.7	BDNF, MAOA, HTR1A, CRH, COMT, PRL
41	personality disorder	13.7	MAOA, HTR1B, TPH1, TPH2, DRD2, DRD3
42	premature ejaculation	13.7	HTR1A, HTR1B, HTR2C, HTR3A, PRL, SLC6A4
43	neurotic disorder	13.7	BDNF, MAOA, HTR1A, HTR2A, HTR3A, DRD2
44	pathological gambling	13.7	MAOA, DRD1, DRD2, DRD3, DRD4, DRD5
45	manic-depressive illness	13.7	MAOA, TPH1, DRD2, DRD3, DRD4, SLC6A4
46	inappropriate adh syndrome	13.7	AVP, POMC, NPPA
47	melancholia	13.7	AVPR1B, MAOA, TRH, CRH, PRL, POMC
48	isolated acth deficiency	13.6	TRH, CRH, PRL, POMC
49	enuresis	13.6	AVP, HTR2A, DRD4, NOS1, NPPA
50	hepatorenal syndrome	13.6	NAGLU, ACE, NPPA, NPY

Clinical features from OMIM: 167870

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 alprazolam, clomipramine, clomipramine hydrochloride, clonazepam, diazepam, fluoxetine, fluoxetine hydrochloride, fluvoxamine, fluvoxamine maleate, imipramine, imipramine hydrochloride, imipramine pamoate, maprotiline, maprotiline hydrochloride, paroxetine, paroxetine hydrochloride, propranolol, propranolol hydrochloride, sertraline, sertraline hydrochloride, temazepam

MalaCards organs/tissues related to panic disorder:

²²

MGI Mouse Phenotypes related to panic disorder:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.9	DRD5, CRHR1, NPY2R, GAL, GAD2, TRH
2	hematopoietic system phenotype	MP:0005397	9.5	HGF, ADA, RGS2, NPY2R, NPR3, TNFRSF21
3	liver/biliary system phenotype	MP:0005370	9.4	PRL, SOD1, NPY2R, NPY5R, ADA, AGT
4	respiratory system phenotype	MP:0005388	8.8	CRHR1, NOS1, ELN, NPSR1, ADORA1, ADA
5	integument phenotype	MP:0010771	8.7	PRL, OPRL1, POMC, NPY1R, SLC6A2, SLC6A4
6	no phenotypic analysis	MP:0003012	8.6	RGS2, NPY1R, POMC, SST, DRD2, TNFRSF21
7	reproductive system phenotype	MP:0005389	8.3	NPR3, NPY1R, NPY2R, RGS7, GAL, GAD2
8	immune system phenotype	MP:0005387	8.1	PRL, AGTR1, COMT, NOS1, CRHR2, POMC
9	renal/urinary system phenotype	MP:0005367	8.0	CTSB, AGT, AGTR1, TAC1, NPPA, NPR3
10	nervous system phenotype	MP:0003631	7.3	PRL, TPH2, TRH, GHRH, HTR3A, HTR2C
11	normal phenotype	MP:0002873	7.2	SLC6A4, NPY1R, NPY, OPRL1, NOS1, PGR
12	digestive/alimentary phenotype	MP:0005381	7.1	DRD2, DRD3, SST, CTSB, NOS1, NPY
13	adipose tissue phenotype	MP:0005375	6.5	CRHR2, NOS1, ACE, AGT, POMC, NPR3
14	growth/size phenotype	MP:0005378	6.3	NPY, NPR3, AGTR1, AGT, ACE, CRH
15	mortality/aging	MP:0010768	6.1	ACE, NOS1, CRHR1, CREM, NTRK3, CTSB
16	muscle phenotype	MP:0005369	5.9	AGT, HCRTR2, ELN, NOS1, SOD1, NPPA
17	cardiovascular system phenotype	MP:0005385	4.2	HGF, ELN, ACE, COMT, NOS1, CRP
18	behavior/neurological phenotype	MP:0005386	3.7	SLC6A4, SLC6A2, NPY5R, NPY2R, NPY1R, NPY
19	homeostasis/metabolism phenotype	MP:0005376	1.4	NPSR1, CRHR1, CRH, PNMT, CTSB, SST

Articles related to panic disorder:

(show top 50)    (show all 217)

id	Title	Authors	Year	Affiliating Genes
1	Neuropeptide S receptor gene - converging evidence fo r a role in panic disorder. (20603625)	Domschke K.... Deckert J.	2010	NPSR1
2	Early response to selective serotonin reuptake inhibi tors in panic disorder is associated with a functional 5-HT1A receptor gene pol ymorphism. (19800133)	Yevtushenko O.O.... Reynolds G.P.	2010	HTR1A
3	Panic disorder and serotonergic genes (SLC6A4, HTR1A and HTR2A): Association and interaction with childhood trauma and parenting. (20817074)	Blaya C.... Manfro G.G.	2010	SLC6A4, HTR1A, HTR2A
4	Association between the obestatin and BDNF gene polymorphism and panic disorder, and depressive disorder. (19352215)	Ishii T.... Kodama K.	2009	BDNF, GHRL
5	Decreased neurokinin-1 (substance P) receptor binding in patients with panic disorder: positron emission tomographic study with [18F ]SPA-RQ. (19200949)	Fujimura Y.... Innis R.B.	2009	TAC1
6	A tryptophan hydroxylase 2 gene polymorphism is associated with panic disorder. (19132526)	Kim Y.K.... Yoon H.K.	2009	TPH2
7	The symptomatic profile of panic disorder is shaped b y the 5-HTTLPR polymorphism. (19683026)	Lonsdorf T.B.... Lindefors N.	2009	SLC6A4
8	Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder. (17573119)	Unschuld P.G.... Keck M.E.	2008	GAL
9	Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. (18452185)	Hodges L.M.... Hamilton S.P.	2008	GRPR
10	Ghrelin gene polymorphism is associated with depression, but not panic disorder. (18797403)	Nakashima K.... Isogawa K.	2008	GHRL
11	The association between serotonin-related gene polymorphisms and panic disorder. (18436425)	Yoon H.K.... Kim Y.K.	2008	TPH1, HTR2A, TPH2
12	Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis. (17705872)	Blaya C.... Manfro G.G.	2007	SLC6A4, SLC5A4
13	Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder. (17440930)	Unschuld P.G.... Keck M.E.	2007	HTR2A
14	Persistent tardive rebound panic disorder, rebound anxiety and insomnia following paroxetine withdrawal: a review of rebound-withdrawal phenomena. (16456219)	Bhanji N.H.... Margolese H.C.	2006	HTR1A, HTR2A
15	Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder. (16511838)	Nakamura K.... Mori N.	2006	TSPO
16	Effects of the cortisol synthesis inhibitor metyrapone on the response to carbon dioxide challenge in panic disorder. (16001448)	Belgorodsky A.... Benjamin J.	2005	CRH
17	Peripheral-type benzodiazepine receptor binding sites in platelets of patients with panic disorder associated to separation anxiety symptoms. (15830231)	Pini S.... Cassano G.B.	2005	TSPO
18	Associations between serotonin-related gene polymorphisms and panic disorder. (15670397)	Maron E.... Shlik J.	2005	MAOA, HTR1B, TPH1
19	NAG level differences in panic disorder and agoraphobia. (16076427)	Garvey M.J.... Noyes R.	2005	NAGLU
20	Investigation of the DAOA/G30 locus in panic disorder. (15477870)	Schumacher J.... Nothen M.M.	2005	DAOA, DAOA-AS1
21	Is premenstrual dysphoria a variant of panic disorder? A review. (15533279)	Vickers K.... McNally R.J.	2004	CCK
22	Impaired GABA neuronal response to acute benzodiazepi ne administration in panic disorder. (15569888)	Goddard A.W.... Krystal J.H.	2004	GAD2
23	Cardiac sympathetic nerve biology and brain monoamine turnover in panic disorder. (15240408)	Esler M.... Richards J.	2004	NPY, PNMT
24	Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression. (12555227)	Tadic A.... Dahmen N.	2003	MAOA
25	Natriuretic peptides and panic disorder: therapeutic prospects. (19810905)	Kellner M.... Wiedemann K.	2003	NPPA
26	Significance of GABAA receptors for the pathophysiology and therapy of panic disorders (12861364)	Rupprecht R.... Zwanzger P.	2003	ABAT
27	Transcriptional activities of cholecystokinin promoter haplotypes and their relevance to panic disorder susceptibility. (12627463)	Ebihara M.... Yoshikawa T.	2003	CCK
28	Antioxidant enzyme and malondialdehyde levels in patients with panic disorder. (12566935)	Kuloglu M.... Bulut S.	2002	SOD1, CAT
29	Catechol O-methyltransferase genetic polymorphism in panic disorder. (12359690)	Woo J.M.... Yu B.H.	2002	COMT
30	Idiopathic environmental intolerance: increased prevalence of panic disorder-associated cholecystokinin B receptor allele 7. (11344357)	Binkley K.... Kennedy J.	2001	CCKBR
31	Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder. (11515749)	Yamada K.... Yoshikawa T.	2001	CCKBR, ADORA2A
32	Investigation of dopamine receptor (DRD4) and dopamine transporter (DAT) polymorphisms for genetic linkage or association to panic disorder. (10898909)	Hamilton S.P.... Knowles J.A.	2000	DRD4
33	Novel 5'-regulatory region polymorphisms of the 5-HT2C receptor gene: association study with panic disorder. (11343611)	Deckert J.... Lesch K.P.	2000	HTR2C
34	Increased psychological responses and divergent neuroendocrine responses to m-CPP and ipsapirone in patients with panic disorder. (10870873)	Broocks A.... Hajak G.	2000	HTR2C, HTR1A
35	Neuropharmacological and genetic study of panic disorder (10495983)	Akiyoshi J.	1999	PTK7, CCK, CRH
36	Effects of citalopram treatment on behavioural, cardiovascular and neuroendocrine response to cholecystokinin tetrapeptide challenge in patients with panic disorder. (9401314)	Shlik J.... Bradwejn J.	1997	PRL, PTK7
37	Plasma neuropeptide Y in anxiety disorders: findings in panic disorder and social phobia. (8930023)	Stein M.B.... Asmundson G.J.	1996	NPY
38	Alpha 2-adrenergic receptor sensitivity in panic disorder: I. GH response to GHRH and clonidine stimulation in panic disorder. (7838898)	Brambilla F.... Bellodi L.	1995	IGF1, GH1, GHRH
39	3H]paroxetine binding to platelets of patients with social phobia: comparison to patients with panic disorder and healthy volunteers. (7711158)	Stein M.B.... Hazen A.L.	1995	SLC6A4
40	The cholecystokinin hypothesis of anxiety and panic disorder. (8185169)	Bradwejn J.... Koszycki D.	1994	CCK
41	Response to meta-chlorophenylpiperazine in panic disorder patients and healthy subjects: influence of reduction in intravenous dosage. (7761547)	Germine M.... Heninger G.R.	1994	PRL
42	Excluding linkage between panic disorder and the gamma-aminobutyric acid beta 1 receptor locus in five Icelandic pedigrees. (8256635)	Schmidt S.M.... Crowe R.R.	1993	GABRB1
43	Prolactin response to dl-fenfluramine in panic disorder. (8416044)	Apostolopoulos M.... Norman T.R.	1993	HTR3A
44	Blunted growth hormone responses to growth hormone-releasing factor and to clonidine in panic disorder. (8422091)	Tancer M.E.... Uhde T.W.	1993	GHRH
45	5-HT1A receptor-effector system responsivity in panic disorder. (1346719)	Lesch K.P.... Schulte H.M.	1992	HTR3A, HTR1A, HTR2A
46	Evidence for hypothalamo-growth hormone dysfunction in panic disorder: profile of growth hormone (GH) responses to clonidine, yohimbine, caffeine, glucose, GRF and TRH in panic disorder patients versus healthy volunteers. (1610485)	Uhde T.W.... Post R.M.	1992	GHRH
47	Psychoimmunoendocrine aspects of panic disorder. (1335559)	Brambilla F.... Sacerdote P.	1992	PRL
48	Endocrine, cardiovascular, and behavioral effects of intravenous protirelin in patients with panic disorder. (1899183)	Stein M.B.... Uhde T.W.	1991	TRH
49	Flumazenil provocation of panic attacks. Evidence for altered benzodiazepine receptor sensitivity in panic disorder. (2171449)	Nutt D.J.... Wilson S.	1990	TSPO
50	Serotonin function in panic disorder: a double blind placebo controlled study with fluvoxamine and ritanserin. (1697419)	den Boer J.A.... Westenberg H.G.	1990	HTR2A

Genes related to panic disorder according to GeneCards:

(show top 50)    (show all 112)

id	Symbol	Description	Score	GeneCards Section Context
1	PAND2	panic disorder 2	11.1	Aliases & Descriptions, Publications
2	PAND1	Panic disorder 1	11.1	Aliases & Descriptions, Publications
3	PAND3	panic disorder 3	11.1	Aliases & Descriptions
4	COMT	catechol-O-methyltransferase	11.0	Publications
5	CCK	cholecystokinin	11.0	Publications
6	PTK7	PTK7 protein tyrosine kinase 7	11.0	Publications
7	CCKBR	cholecystokinin B receptor	11.0	Publications
8	TSPO	translocator protein (18kDa)	11.0	Publications
9	CCKAR	cholecystokinin A receptor	11.0	Publications
10	GHRH	growth hormone releasing hormone	11.0	Publications
11	MAOA	monoamine oxidase A	11.0	Publications, Functions
12	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	11.0	Publications
13	TPH1	tryptophan hydroxylase 1	11.0	Publications
14	TPH2	tryptophan hydroxylase 2	11.0	Publications
15	ADORA2A	adenosine A2a receptor	11.0	Publications
16	TRH	thyrotropin-releasing hormone	11.0	Publications
17	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
18	CRH	corticotropin releasing hormone	11.0	Publications
19	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications
20	SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	11.0	Publications
21	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11.0	Publications
22	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0	Publications
23	TTF2	transcription termination factor, RNA polymerase II	11.0	Publications
24	NPR3	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	11.0	Publications
25	HTR2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	11.0	Publications
26	DRD4	dopamine receptor D4	11.0	Publications
27	ABAT	4-aminobutyrate aminotransferase	11.0	Publications
28	RPS9P4	ribosomal protein S9 pseudogene 4	11.0	Publications
29	MIR488	microRNA 488	11.0	Publications
30	MIR138-2	microRNA 138-2	11.0	Publications
31	MIR148A	microRNA 148a	11.0	Publications
32	MIR22	microRNA 22	11.0	Publications
33	DAOA-AS1	DAOA antisense RNA 1	11.0	Publications
34	IGKV2D-29	immunoglobulin kappa variable 2D-29	11.0	Publications
35	GABRA6	gamma-aminobutyric acid (GABA) A receptor, alpha 6	11.0	Publications
36	SLC5A4	solute carrier family 5 (low affinity glucose cotransporter), member 4	11.0	Publications
37	RNY5	RNA, Ro-associated Y5	11.0	Publications
38	DAOA	D-amino acid oxidase activator	11.0	Publications
39	CALCOCO1	calcium binding and coiled-coil domain 1	11.0	Publications
40	AVPR1B	arginine vasopressin receptor 1B	11.0	Publications
41	PNMT	phenylethanolamine N-methyltransferase	11.0	Publications
42	LDHB	lactate dehydrogenase B	11.0	Publications
43	AVPR1A	arginine vasopressin receptor 1A	11.0	Publications
44	RGS2	regulator of G-protein signaling 2, 24kDa	11.0	Publications
45	NPSR1	neuropeptide S receptor 1	11.0	Publications
46	GRPR	gastrin-releasing peptide receptor	11.0	Publications
47	AVP	arginine vasopressin	11.0	Publications
48	LDHA	lactate dehydrogenase A	11.0	Publications
49	DRD5	dopamine receptor D5	11.0	Publications
50	OPRL1	opiate receptor-like 1	11.0	Publications

Pathways related to panic disorder according to GeneDecks:

(show all 22)

id	Pathway	Score	Top Affiliating Genes
1	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	10.8	SLC6A4, TPH2, TPH1, HTR2A, HTR1A, MAOA
2	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics34	10.5	POMC, CRHR2, CRHR1, CRH
3	ACE Inhibitor Pathway, Pharmacodynamics34	10.5	AGTR1
4	Class A/1 (Rhodopsin-like receptors)38	10.3	GAL, NPY5R, NPY2R, NPY1R, NPY, OPRL1
5	Amine ligand-binding receptors38	10.3	DRD5, DRD4, DRD3, DRD2, DRD1, HTR2C
6	Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics34	10.2	DRD4, DRD3, DRD2, DRD1, CHRNA4
7	G alpha (q) signalling events38	10.2	HCRTR1, HCRTR2, AGTR1, TAC1, GRPR, TRH
8	Calcium signaling pathway20	10.1	DRD5, NOS1, AGTR1, ADORA2A, GRPR, DRD1
9	Methotrexate Pathway (Cancer Cell), Pharmacodynamics34	10.1	GGH, ADA, ADORA1, ADORA2A
10	G alpha (s) signalling events38	10.0	PDE4B, AVP, POMC, NPSR1
11	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q10	9.9	GRPR, AVPR1B, AVPR1A, CCKBR, CCKAR, GAL
12	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	9.9	KNG1, AGTR1, AGT, ACE
13	Doxorubicin Pathway, Pharmacokinetics34	9.6	SOD1, NOS1, CAT, XDH
14	Akt Signaling36	9.4	GABRB1, GABRA6, HGF, NTRK3, PTK7, TNFRSF21
15	Intracellular Calcium Signaling36	9.3	GH1, GHRH, PTK7, NTRK3, HGF, HTR3A
16	eNOS Signaling36	8.9	HGF, NTRK3, PTK7, GHRH, GH1, ESR1
17	Renin-Angiotensin Pathway36	8.8	HGF, AGTR1, AGT, ACE, NTRK3, GHRH
18	Activation of cAMP-Dependent PKA36	8.5	HGF, CRP, CRHR2, CRHR1, CREM, NTRK3
19	cAMP Pathway36	8.3	HGF, RGS7, RGS2, CRP, CRHR2, CRHR1
20	JAK-STAT Pathway36	8.2	HGF, PRL, AGTR1, AGT, NTRK3, PTK7
21	Neuroactive ligand-receptor interaction20	8.1	GRPR, GABRB1, GABRA6, ADORA1, ADORA2A, NPY5R
22	Estrogen Pathway36	8.0	HGF, NTRK3, PTK7, GHRH, GH1, ESR1

Compounds related to panic disorder according to GeneDecks:

(show top 50)    (show all 509)

id	Compound	Score	Top Affiliating Genes
1	nicotine32 34 9 9	13.9	SLC6A2, CRH, CCKBR
2	paroxetine32 34 9 9	13.3	PRL, COMT, DRD4, TPH1, GHRL, HTR3A
3	maoa32	10.3	BDNF, MAOA, HTR1A, SLC6A4, SLC6A2, POMC
4	propranolol32 34 9 18 9	14.3	CRH, CYP3A4, PTK7, GHRH, HTR3A, HTR2C
5	fenfluramine32 9 9	12.3	CRH, TPH1, TRH, GHRH, HTR3A, HTR2C
6	5-hydroxytryptophan32	10.2	HTR1A, SLC6A4, PRL, CRH, SST, PTK7
7	imipramine32 34 9 18 9	14.1	ADORA1, SLC6A4, SLC6A2, ABAT, NOS1, CYP3A4
8	amphetamine32 9 9	12.0	GAL, SLC6A4, SLC6A2, NPY, POMC, TAC1
9	apomorphine32 9 9	11.9	PRL, COMT, DRD5, DRD4, DRD3, DRD2
10	aripiprazole32 34 9 18 9	13.9	PRL, CYP3A4, DRD5, DRD4, DRD3, DRD2
11	ziprasidone32 9 9	11.9	DRD2, DRD1, HTR3A, HTR2C, HTR2A, HTR1B
12	morphine32 9 9	11.9	DRD2, DRD1, TRH, CCKAR, CCK, CCKBR
13	6-hydroxydopamine32	9.8	SLC6A2, NPY, SOD1, TAC1, COMT, DRD4
14	corticosterone32 18	10.8	CRHR1, CRH, PNMT, GHRL, GH1, AVPR1B
15	clomipramine32 34 9 9	12.7	SLC6A4, SLC6A2, PRL, TSPO, CRH, CYP3A4
16	catecholamine32	9.6	GAL, SLC6A2, NPY, NPPA, BDNF, AVP
17	sodium nitroprusside32	9.6	AGTR1, ELN, CRH, SST, TPH1, CAT
18	gnrh32	9.5	GAL, NPY, POMC, CRHR2, CRH, TRH
19	ethanol32 34 9 18 9	13.4	HGF, ADORA2A, SLC6A2, NPY5R, TTF2, AGTR1
20	tetrodotoxin32	9.4	NPY, TAC1, NOS1, CRH, CTSB, HTR3A
21	spec-t32	9.4	SLC6A2, NPPA, TSPO, CRHR1, CRH, SST
22	pyridostigmine32 9 9	11.3	GHRH, GH1, IGF1, GHRL, TRH, CYP3A4
23	atropine32 9 9	11.3	GAL, ADA, ADORA1, KNG1, NPY, TAC1
24	epinephrine32 9 18 9	12.3	SLC6A2, NPY, NPPA, POMC, TAC1, AGTR1
25	risperidone32 34 9 18 9	13.2	HTR2A, HTR1A, IL10, BDNF, HTR2C, HTR3A
26	cysteine32	9.1	AGT, COMT, NOS1, CRH, CTSB, DRD1
27	acth32	9.0	PTK7, TRH, GHRL, GHRH, IGF1, CCK
28	gaba32 42	9.9	GAD2, GAL, GABRB1, GABRA6, ADORA1, ADORA2A
29	fluoxetine32 34 9 9	11.9	CRHR1, CRH, CYP3A4, DRD2, TPH2, TPH1
30	5-hydroxytryptamine32	8.8	SLC6A2, HTR3A, HTR2C, HTR2A, HTR1B, HTR1A
31	naloxone32 34 9 9	11.7	CYP3A4, DRD1, TRH, GHRL, GHRH, GH1
32	melatonin32 42 9 18 9	12.7	DRD4, TPH1, TRH, GH1, ESR1, HTR3A
33	aspartate32	8.5	GH1, CCKBR, APOE, BDNF, NAGLU, GHRH
34	clozapine32 34 9 9	11.5	ADORA2A, SLC6A4, POMC, PRL, NOS1, CRP
35	glutamate32	8.1	GGH, GAD2, GAL, HGF, ADA, ADORA1
36	alanine32	8.0	HCRTR2, HCRTR1, ELN, ABAT, CRP, CRHR1
37	testosterone32 9 18 9	10.9	TAC1, TSPO, ELN, NOS1, CRHR1, CRH
38	indomethacin32 9 9	9.8	HGF, ADA, KNG1, PGR, NPY, POMC
39	histamine32 18	8.7	ADORA1, ADORA2A, KNG1, SLC6A2, NPY5R, NPY1R
40	l-nmma32	7.7	GHRL, GH1, CAT, IGF1, CCK, XDH
41	nmda32 42	8.6	GRM8, BDNF, TSPO, COMT, NOS1, NTRK3
42	creatinine32	7.6	ADA, NPY, POMC, TSPO, TTF2, AGTR1
43	dopamine32 9 18 9	10.6	NOS1, CRHR2, CRHR1, CRH, PNMT, SST
44	adenylate32	7.4	NPY, NPR3, POMC, OPRL1, TAC1, AGT
45	calcium32 9 18 9	10.3	IGKV2D-29, IKBKE, CCKAR, CCK, CCKBR, ANO2
46	nitric oxide32 9 18 9	10.0	PNMT, NAGLU, LDHA, XDH, CTSB, DRD1
47	norepinephrine32 9 18 9	9.8	SLC6A2, PNMT, SST, PTK7, DRD5, DRD4
48	dexamethasone32 42 34 9 9	10.3	AGTR1, AGT, ELN, NOS1, CRHR1, CRH
49	arginine32	6.1	AGT, AVPR1A, AVP, XDH, AVPR1B, APOE
50	vegf32	4.8	GRPR, HGF, ADA, ADORA2A, PGR, NPR3

Cellular components related to panic disorder according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	terminal button	GO:043195	10.1	ADORA1, DRD4, GHRH, CCKAR, CCK
2	presynaptic membrane	GO:042734	9.6	GRM7, GRM8, ADORA2A, ADORA1, GAD2
3	axon	GO:030424	9.5	GAD2, NPY1R, TAC1, DRD2, DRD1, TNFRSF21
4	neuronal cell body	GO:043025	8.8	TAC1, SOD1, ADORA2A, ADORA1, ADA, SST
5	integral to plasma membrane	GO:005887	8.2	GRPR, CRHR2, HCRTR1, HCRTR2, AGTR1, OPRL1
6	extracellular space	GO:005615	6.1	TAC1, AGT, ACE, CRP, SOD1, POMC
7	extracellular region	GO:005576	6.0	PRL, TAC1, AGT, CRP, SOD1, POMC
8	plasma membrane	GO:005886	5.5	NPSR1, SOD1, OPRL1, TAC1, AGTR1, HCRTR2

Biological processes related to panic disorder according to GeneDecks:

(show top 50)    (show all 73)

id	Name	GO ID	Score	Top Affiliating Genes
1	eating behavior	GO:042755	10.7	ADORA2A, NPY5R, DRD1, TRH, CCK
2	positive regulation of glutamate secretion	GO:014049	10.7	ADORA2A, AVPR1B, AVPR1A, AVP
3	regulation of systemic arterial blood pressure by vasopressin	GO:001992	10.7	DRD5, AVPR1B, AVPR1A
4	ERK1 and ERK2 cascade	GO:070371	10.6	AVP, CCKBR, HTR2A, HTR2C, AGT
5	social behavior	GO:035176	10.6	GRPR, SLC6A4, DRD4, DRD3, AVPR1A, AVP
6	temperature homeostasis	GO:001659	10.6	ADORA1, DRD2, DRD1, HTR2A, CCKAR
7	positive regulation of cellular pH reduction	GO:032849	10.5	AVPR1B, AVPR1A, AVP
8	behavioral response to cocaine	GO:048148	10.5	ABAT, DRD4, DRD3, DRD2, DRD1
9	negative regulation of synaptic transmission, glutamatergic	GO:051967	10.5	HTR1B, HTR2A, DRD2, ADORA1
10	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	GO:007193	10.5	ADORA1, NPY2R, NPY1R, NPR3, OPRL1
11	synaptic transmission, dopaminergic	GO:001963	10.5	ADORA2A, CRH, DRD5, DRD4, DRD3, DRD2
12	response to histamine	GO:034776	10.5	DRD4, DRD3, DRD2
13	grooming behavior	GO:007625	10.5	DRD2, DRD1, AVPR1A, AVP
14	neurotransmitter biosynthetic process	GO:042136	10.5	GAD2, COMT, NOS1, MAOA
15	phospholipase C-activating G-protein coupled receptor signaling pathway	GO:007200	10.5	NPR3, CCKBR, CCKAR, HCRTR2, AGT, AGTR1
16	dopamine metabolic process	GO:042417	10.5	DRD1, DRD2, DRD3, DRD4
17	response to cocaine	GO:042220	10.4	DRD5, DRD3, DRD2, HTR3A, HTR1B
18	regulation of dopamine secretion	GO:014059	10.4	DRD3, DRD2, HTR2A, HTR1B, CHRNA4
19	phospholipase C-activating dopamine receptor signaling pathway	GO:060158	10.4	DRD1, DRD2, DRD5
20	negative regulation of blood pressure	GO:045776	10.4	ADORA1, NPY, ABAT, DRD5, DRD3, DRD2
21	prepulse inhibition	GO:060134	10.4	ADORA2A, DRD3, DRD2, DRD1
22	negative regulation of glutamate secretion	GO:014050	10.4	GRM7, TRH, NPY5R, ADORA1
23	regulation of dopamine uptake involved in synaptic transmission	GO:051584	10.4	DRD2, DRD3, DRD1
24	positive regulation of urine volume	GO:035810	10.4	ADORA2A, KNG1, NPR3, DRD2
25	response to amphetamine	GO:001975	10.3	ADORA2A, SOD1, DRD5, DRD4, DRD3, DRD2
26	regulation of renal sodium excretion	GO:035813	10.3	AGTR1, AGT, AVP
27	feeding behavior	GO:007631	10.3	BDNF, GAL, NPY1R, NPY, HCRTR2, HCRTR1
28	positive regulation of multicellular organism growth	GO:040018	10.3	AGT, DRD2, GHRL, GHRH, GH1
29	positive regulation of growth hormone secretion	GO:060124	10.3	DRD2, GHRL, GHRH
30	response to ethanol	GO:045471	10.2	GGH, SOD1, ABAT, CTSB, DRD3, TRH
31	arachidonic acid secretion	GO:050482	10.2	DRD2, DRD3, DRD4, ACE
32	locomotory behavior	GO:007626	10.2	ADORA2A, NPY2R, NPY1R, SOD1, ABAT, DRD3
33	behavioral fear response	GO:001662	10.2	DRD4, DRD1, CCK, GRM7
34	positive regulation of renal sodium excretion	GO:035815	10.2	ADORA2A, KNG1, TAC1, AGT, DRD2, AVPR1A
35	relaxation of vascular smooth muscle	GO:060087	10.2	ADORA1, RGS2, SOD1
36	response to nicotine	GO:035094	10.2	ABAT, DRD2, AVP, CHRNA4
37	elevation of cytosolic calcium ion concentration	GO:007204	10.1	KNG1, OPRL1, TAC1, AGTR1, GHRL, GHRH
38	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO:007195	10.1	DRD4, DRD3, DRD2
39	negative regulation of cAMP biosynthetic process	GO:030818	10.1	GRM7, GRM8, HTR1B, DRD4
40	regulation of blood pressure	GO:008217	10.1	NPY1R, NPR3, NPPA, POMC, SOD1, TAC1
41	positive regulation of vasoconstriction	GO:045907	10.0	HTR2A, AVPR1A, AVP, NPY1R
42	negative regulation of adenylate cyclase activity	GO:007194	9.9	NPR3, DRD4, DRD3, DRD2, GRM8, GRM7
43	regulation of multicellular organism growth	GO:040014	9.6	NPY1R, SOD1, PRL, DRD3, IGF1
44	synaptic transmission	GO:007268	9.6	ABAT, HCRTR1, HCRTR2, TAC1, NPY, SLC6A2
45	response to hypoxia	GO:001666	9.5	ADA, ADORA1, SLC6A4, ABAT, NOS1, CRP
46	cell-cell signaling	GO:007267	9.3	ADORA1, ADORA2A, PGR, POMC, TAC1, AGT
47	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.3	HGF, AGT, GH1, CAT, IGF1
48	response to drug	GO:042493	9.1	ABAT, TSPO, SOD1, SLC6A4, ADORA2A, GAL
49	G-protein coupled receptor signaling pathway	GO:007186	8.9	CRHR1, AGT, AGTR1, NPY5R, RGS7, GRPR
50	signal transduction	GO:007165	8.3	CREM, CRH, PKP1, POMC, PGR, ADORA1

Molecular functions related to panic disorder according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	serotonin binding	GO:051378	10.6	HTR3A, HTR2C, HTR2A, HTR1B, HTR1A, MAOA
2	serotonin receptor activity	GO:004993	10.5	HTR3A, HTR2C, HTR2A, HTR1B, HTR1A
3	dopamine receptor activity	GO:004952	10.5	DRD5, DRD4, DRD1
4	neuropeptide hormone activity	GO:005184	10.4	GAL, NPY, CRH, TRH, CCK, AVP
5	peptide YY receptor activity	GO:001601	10.3	NPY1R, NPY2R, NPY5R
6	neuropeptide Y receptor activity	GO:004983	10.3	NPY1R, NPY2R, NPY5R
7	vasopressin receptor activity	GO:005000	10.3	NPSR1, AVPR1B, AVPR1A
8	dopamine binding	GO:035240	10.3	DRD5, DRD4, DRD3, DRD2, DRD1
9	dopamine receptor activity, coupled via Gi/Go	GO:001591	10.2	DRD4, DRD3, DRD2
10	peptide hormone binding	GO:017046	10.0	AVPR1A, AVPR1B, HCRTR2, NPR3
11	drug binding	GO:008144	10.0	HTR1A, ACE, DRD5, DRD4, DRD3, DRD2
12	hormone activity	GO:005179	9.1	NPPA, POMC, PRL, AGT, CRHR2, CRH