PANIC
MCID: PNC025
MIFTS: 63

Panic Disorder (PANIC) malady

Mental diseases category

Summaries for Panic Disorder

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9Disease Ontology, 35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Panic disorder is a type of anxiety disorder. it causes panic attacks, which are sudden feelings of terror when there is no real danger. you may feel as if you are losing control. you may also have physical symptoms, such as fast heartbeat chest or stomach pain breathing difficulty weakness or dizziness sweating feeling hot or a cold chill tingly or numb hands panic attacks can happen anytime, anywhere, and without warning. you may live in fear of another attack and may avoid places where you have had an attack. for some people, fear takes over their lives and they cannot leave their homes. panic disorder is more common in women than men. it usually starts when people are young adults. sometimes it starts when a person is under a lot of stress. most people get better with treatment. therapy can show you how to recognize and change your thinking patterns before they lead to panic. medicines can also help. nih: national institute of mental health

MalaCards: Panic Disorder, also known as panic anxiety syndrome, is related to agoraphobia and generalized anxiety disorder. An important gene associated with Panic Disorder is COMT (catechol-O-methyltransferase), and among its related pathways are Biogenic Amine Synthesis and Monoamine GPCRs. The compounds cholecystokinin tetrapeptide and asperlicin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and cortex, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Disease Ontology:9 An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.

Wikipedia:66 Panic disorder is an anxiety disorder characterized by recurring panic attacks. It may also include... more...

Description from OMIM:48 167870

Aliases & Classifications for Panic Disorder

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Sources:
9Disease Ontology, 48OMIM, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

panic disorder 9 48 11 46 35
panic anxiety syndrome 9
panic disorder 1 63
panic 46


External Ids:

Disease Ontology9 DOID:594
NCIt41 C34890
MeSH36 D016584
ICD1026 F41.0

Related Diseases for Panic Disorder

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Panic Disorder family:

Panic Disorder 3 Panic Disorder 2
Panic Disorder Syndrome 1

Diseases related to Panic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1agoraphobia32.0CCKBR, HTR1A, PTK7
2generalized anxiety disorder31.2TSPO, HTR1A
3social phobia31.2COMT, HTR1A
4anxiety disorder30.9PTK7, TPH2, TPH1, TSPO, CCK, CRH
5schizophrenia30.7COMT, HTR2A
6obsessive-compulsive disorder30.7TPH2, TPH1, TSPO, HTR1A, COMT, HTR2A
7personality disorder30.7TPH1, TPH2
8irritable bowel syndrome30.6TPH1, CRH, CCK
9bipolar disorder30.5HTR2A, HTR1A, CRH, TPH1
10migraine30.3COMT, HTR1A, HTR2A, TPH1
11substance dependence30.1COMT, TPH1
12eating disorder30.1HTR2A, CCK, CRH, HTR1A, CCKAR, COMT
13hyperprolactinemia30.1GHRH, CRH
14mood disorder30.0TPH1, HTR2A, HTR1A, COMT, CRH, TPH2
15attention deficit hyperactivity disorder30.0TPH2, HTR2A, COMT
16seasonal affective disorder29.9HTR2A, CRH, TPH1, HTR1A
17psychotic disorder29.8HTR2A, TPH2, COMT, HTR1A, CCK, TPH1
18major depressive disorder10.7
19alexithymia10.5
20mitral valve prolapse10.4
21separation anxiety disorder10.4
22blindness10.4
23hypochondriasis10.4
24specific phobia10.4
25neuronitis10.3
26somatoform disorder10.3
27thyroiditis10.3
28panic disorder 310.3
29post-traumatic stress disorder10.2
30hypermobility syndrome10.2
31hypophosphatemia10.2
32seizure disorder10.2
33panic disorder 210.2
34insomnia10.2
35coronary artery disease10.2
36cerebritis10.2
37artery disease10.2
38asthma10.2
39hypertension10.2
40panic disorder syndrome 110.2
41paranoid schizophrenia10.1COMT
42acute stress disorder10.1
43dyspepsia10.1CCK
44neuroleptic malignant syndrome10.1HTR1A
45endogenous depression10.1CRH
46neuroendocrine tumor10.1GHRH
47antisocial personality disorder10.1HTR2A
48amnestic disorder10.1TSPO, HTR1A
49pancreas disease10.1CCKAR, CCK
50gastroesophageal reflux disease10.1CCK, CCKAR

Graphical network of the top 20 diseases related to Panic Disorder:



Diseases related to panic disorder

Symptoms for Panic Disorder

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Sources:
48OMIM
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Symptoms by clinical synopsis from OMIM:

167870

Clinical features from OMIM:

167870

Drugs & Therapeutics for Panic Disorder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Panic Disorder

Drug clinical trials:

Search ClinicalTrials for Panic Disorder

Search NIH Clinical Center for Panic Disorder

Search CenterWatch for Panic Disorder

Genetic Tests for Panic Disorder

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Anatomical Context for Panic Disorder

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34MalaCards
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MalaCards organs/tissues related to Panic Disorder:

34
Heart, Brain, Cortex, Testes, Prefrontal cortex, Amygdala, Cingulate cortex, Pituitary, Thyroid, Hypothalamus, T cells, Skin, Breast, Lung, Eye

Animal Models for Panic Disorder or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Panic Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053887.9TPH2, TPH1, CCKAR, CRH, PTK7
2MP:00053797.8CCK, CCKBR, CCKAR, HTR2A, GHRH, CRH
3MP:00053857.6CCKBR, HTR1A, TPH1, TPH2, PTK7, COMT
4MP:00053787.0TPH2, PTK7, CRH, GHRH, CCKBR, TPH1
5MP:00036316.8PTK7, CRH, TPH2, CCK, CCKBR, CCKAR
6MP:00053766.5TPH2, TPH1, CCK, CCKBR, CCKAR, HTR1A
7MP:00053866.5TPH1, TPH2, CCKBR, CCKAR, HTR2A, HTR1A

Publications for Panic Disorder

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Sources:
53PubMed
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Articles related to Panic Disorder:

(show top 50)    (show all 1017)
idTitleAuthorsYear
1
GENDER-SPECIFIC ASSOCIATION OF VARIANTS IN THE AKR1C1 GENE WITH DIMENSIONAL ANXIETY IN PATIENTS WITH PANIC DISORDER: ADDITIONAL EVIDENCE FOR THE IMPORTANCE OF NEUROSTEROIDS IN ANXIETY? (24390875)
2014
2
Are TMEM genes potential candidate genes for panic disorder? (24362369)
2014
3
MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy. (23319006)
2014
4
Treatment Modality Preferences and Adherence to Group Treatment for Panic Disorder with Agoraphobia. (24136085)
2013
5
A Psychometric Evaluation of the Panic Disorder Severity Scale for Children and Adolescents. (24295237)
2013
6
Structural neuroimaging in patients with panic disorder: findings and limitations of recent studies. (23793273)
2013
7
Comparison of heart rate variability in patients with panic disorder during cognitive behavioral therapy program. (23470608)
2013
8
A possible association between panic disorder and a polymorphism in the preproghrelingene. (23084284)
2013
9
Modeling panic disorder in rodents. (23584609)
2013
10
Using brain imaging to understand the response to cognitive therapy in panic disorder. (24185237)
2013
11
The effect of escitalopram on metabolic parameters in patients with major depressive disorder, generalised anxiety disorder, and panic disorder: a prospective 6-month follow-up study. (23642988)
2013
12
Neural correlates of the emotional Stroop task in panic disorder patients: an event-related fMRI study. (23058446)
2012
13
The role of the amygdala in the pathophysiology of panic disorder: evidence from neuroimaging studies. (23168129)
2012
14
Reliability of the emotional Stroop task: an investigation of patients with panic disorder. (22770507)
2012
15
Escitalopram increased gray matter and white matter in a first-episode drug-naA^ve panic disorder patient within 6 weeks. (22772685)
2012
16
Opposing breathing therapies for panic disorder: a randomized controlled trial of lowering vs raising end-tidal P(COa88). (22901344)
2012
17
Panic-focused psychodynamic psychotherapy in a woman with panic disorder and generalized anxiety disorder. (23030215)
2012
18
Dissociation between ACTH and cortisol response in DEX-CRH test in patients with panic disorder. (22277728)
2012
19
Neuropeptide S receptor genea88--a88converging evidence for a role in panic disorder. (20603625)
2011
20
New daily persistent headache and panic disorder. (20851838)
2011
21
Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways. (21168126)
2011
22
Depersonalization and personality in panic disorder. (21683177)
2011
23
Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder. (19969287)
2010
24
Cigarette smoking and 35% CO(2) induced panic in panic disorder patients. (19896718)
2010
25
Genetics of panic disorder: focus on association studies and therapeutic perspectives. (20662753)
2010
26
No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population. (19461660)
2009
27
Panic disorder and social anxiety disorder subtypes in a caffeine challenge test. (19698996)
2009
28
Panic disorder subtypes: deceptive somatic impersonators. (19763206)
2009
29
Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val158Met genotype in patients with panic disorder during a verbal fluency task: near-infrared spectroscopy study. (19429001)
2009
30
Cognitive-behavioral treatment for panic disorder with agoraphobia: a randomized, controlled trial and cost-effectiveness analysis. (18391051)
2008
31
Alexithymia and cognitive dysfunctions in patients with panic disorder. (18332616)
2008
32
An open-label study of tiagabine in panic disorder. (18007567)
2007
33
Negative evidences in association between apolipoprotein E polymorphism and panic disorder. (15961292)
2006
34
Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study. (15930067)
2005
35
Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. (15667435)
2005
36
Lack of association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and panic disorder in humans. (15158002)
2004
37
Clinical and psychosocial outcome of patients affected by panic disorder with or without agoraphobia: results from a naturalistic follow-up study. (12547305)
2002
38
No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder. (11244486)
2001
39
Long-term treatment of panic disorder with agoraphobia in private practice. (15990481)
2000
40
Preattentive bias for emotional information in panic disorder with agoraphobia. (10369032)
1999
41
Long-term maintenance and discontinuation of imipramine therapy in panic disorder with agoraphobia. (12884888)
1999
42
Embarrassment about the first panic attack predicts agoraphobia in panic disorder patients. (9159975)
1997
43
Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). (9373423)
1997
44
Explicit and implicit memory bias in panic disorder with agoraphobia. (9431730)
1997
45
A meta-analysis of the treatment of panic disorder with or without agoraphobia: a comparison of psychopharmacological, cognitive-behavioral, and combination treatments. (9284865)
1997
46
Association of levels of N-acetyl-beta-glucosaminidase with severity of psychiatric symptoms in panic disorder. (8723309)
1996
47
On the significance of cholecystokinin receptors in panic disorder. (7863014)
1994
48
CSF cholecystokinin concentrations in patients with panic disorder and in normal comparison subjects. (1575262)
1992
49
5-HT1A receptor-effector system responsivity in panic disorder. (1346719)
1992
50
Thyroid hormones in panic disorder, panic disorder with agoraphobia, and generalized anxiety disorder. (3379028)
1988

Variations for Panic Disorder

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Expression for genes affiliated with Panic Disorder

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Panic Disorder

Search GEO for disease gene expression data for Panic Disorder.

Pathways for genes affiliated with Panic Disorder

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 54QIAGEN, 52PharmGKB
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Pathways related to Panic Disorder according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
catecholamine biosynthesis39
9.7TPH1, COMT
2
Show member pathways
9.5HTR1A, HTR2A
3
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)39
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA39
tryptophan degradation39
glutaryl-CoA degradation39
serotonin degradation39
NAD de novo biosynthesis39
superpathway of melatonin degradation39
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde39
tryptophan utilization I39
melatonin degradation I39
9.1TPH2, TPH1
4
Show member pathways
serotonin and melatonin biosynthesis39
9.1TPH2, TPH1
59.1CCKAR, HTR2A, CCKBR
6
Show member pathways
8.8CCKAR, HTR2A, CCK, CCKBR
7
Show member pathways
8.7GHRH, PTK7, HTR2A, HTR1A
88.1TPH2, TPH1, HTR2A, HTR1A
98.1TPH2, TPH1, HTR2A, HTR1A
10
Show member pathways
7.9COMT, HTR1A, HTR2A, TPH1, TPH2
11
Show member pathways
7.5HTR2A, CCKBR, CRH, GHRH, HTR1A, CCKAR
12
Show member pathways
7.1CCKBR, CCK, TSPO, HTR2A, HTR1A, GHRH

Compounds for genes affiliated with Panic Disorder

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Sources:
46Novoseek, 30IUPHAR, 62Tocris Bioscience, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Panic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 223)
idCompoundScoreTop Affiliating Genes
1cholecystokinin tetrapeptide469.9CCKBR, CCK, PTK7
2asperlicin469.9CCKAR, CCK, PTK7
31,4-benzodiazepine469.8CCKAR, CCK, TSPO
4lorglumide46 3010.8CCKBR, CCK, CCKAR
5l365260469.8CCKAR, CCKBR, CCK
6ym022469.8CCK, CCKBR, CCKAR
7devazepide46 62 3011.7CCKAR, CCKBR, CCK
8loxiglumide469.7CCKAR, CCKBR, CCK
9benzodiazepines469.5TSPO, CCKAR, CCK, CCKBR
10tetrapeptide469.4CCKAR, CCKBR, PTK7, CCK
11inositol triphosphate469.3CCKBR, CRH, CCK
12raclopride46 3010.3HTR2A, CCK, HTR1A, CCKBR
13buspirone46 30 1211.2TSPO, HTR2A, HTR1A
14morphine46 52 30 1212.2CCKBR, CCKAR, COMT, CCK, TSPO
15ondansetron52 46 25 1212.1HTR1A, HTR2A, CCK, CCKAR
16naloxone46 30 52 1212.1TSPO, GHRH, CCK, CRH
17methysergide46 30 1211.1CCK, HTR1A, HTR2A
18tetrodotoxin46 62 3011.1CCKAR, CRH, CCKBR, CCK
19bromocriptine46 30 1211.0HTR2A, HTR1A, GHRH, COMT
20clomipramine46 52 1211.0HTR1A, HTR2A, TSPO, CRH
21paroxetine46 52 30 1212.0HTR2A, COMT, HTR1A, TPH1
22amide469.0GHRH, CCK, CCKBR, CCKAR
23atropine46 30 1211.0CCKAR, CRH, GHRH, CCK
24opiate469.0GHRH, CCK, TSPO, CRH
25yohimbine46 3 30 1212.0HTR1A, HTR2A, CRH, CCKBR
26ropinirole46 129.9HTR2A, HTR1A, COMT
27levodopa46 129.9TPH1, TSPO, HTR1A, GHRH, COMT
28octreotide46 62 30 1211.9CRH, GHRH, CCKAR, CCKBR, CCK
29haloperidol46 52 30 3 1212.8HTR1A, HTR2A, CCKAR, TSPO, CCKBR
30venlafaxine46 52 25 1211.8TPH2, HTR2A, HTR1A, COMT
31nicotine46 30 52 1211.8COMT, CCKBR, TSPO, TPH1, CRH
32fluvoxamine46 52 1210.8TPH1, TSPO, HTR1A, COMT, HTR2A
33l-tryptophan52 30 46 25 1212.8TPH1, TPH2, TSPO, HTR1A
34benzodiazepine468.7PTK7, CCK, CCKBR, CCKAR, CRH, TSPO
35cocaine46 129.7CRH, COMT, CCKBR, CCK, CCKAR, TSPO
36propranolol46 30 52 25 1212.7HTR1A, PTK7, GHRH, COMT, CRH, TSPO
37acth468.6HTR1A, CRH, GHRH, CCKBR, PTK7, CCK
385-hydroxytryptophan468.6CRH, PTK7, HTR2A, HTR1A, TPH1
39citalopram46 52 25 1211.6CRH, HTR2A, HTR1A, PTK7, TPH1
40antidepressants528.5HTR1A, HTR2A, TPH1, TPH2
41gaba468.5CCKAR, CRH, PTK7, TPH1, TSPO, CCK
42acetylcholine46 52 30 25 1212.4CRH, HTR1A, CCKBR, TSPO, CCK, TPH1
43maoa468.3TPH1, TPH2, HTR2A, COMT, HTR1A
44phenylalanine468.3TPH1, CCK, CCKBR, CCKAR, TPH2
45fluoxetine46 52 30 1211.0CRH, TPH1, TPH2, HTR2A, HTR1A
46glutamate468.0TPH1, COMT, GHRH, CCKBR, CCK, TSPO
47fenfluramine46 30 129.3HTR1A, GHRH, CRH, CCK, TPH1, TPH2
48norepinephrine46 25 129.2CCK, HTR2A, HTR1A, GHRH, COMT, CRH
495-hydroxytryptamine467.1TPH2, TPH1, TSPO, CCK, HTR2A, HTR1A
50dopamine46 30 25 129.5CRH, COMT, GHRH, HTR1A, HTR2A, CCKAR

GO Terms for genes affiliated with Panic Disorder

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Sources:
17Gene Ontology
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Cellular components related to Panic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1terminal boutonGO:0431959.7GHRH, CCK
2integral component of plasma membraneGO:0058878.2HTR1A, HTR2A, CCKAR, CCKBR, PTK7

Biological processes related to Panic Disorder according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1cholecystokinin signaling pathwayGO:03818810.1CCKBR, CCKAR
2positive regulation of mitochondrial depolarizationGO:05190110.1TSPO, CCK
3regulation of serotonin secretionGO:0140629.9CRH, HTR1A
4behavioral fear responseGO:0016629.8HTR1A, CCK
5response to painGO:0482659.8COMT, CRH
6regulation of hormone secretionGO:0468839.8HTR2A, HTR1A
7response to immobilization stressGO:0359029.7TPH1, CRH
8adrenal gland developmentGO:0303259.7TSPO, CRH
9serotonin receptor signaling pathwayGO:0072109.7HTR1A, HTR2A
10regulation of behaviorGO:0507959.6HTR2A, HTR1A
11feeding behaviorGO:0076319.6CRH, CCKBR, CCKAR
12phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.4CCKAR, CCKBR
13serotonin biosynthetic processGO:0424279.4TPH2, TPH1
14aromatic amino acid family metabolic processGO:0090729.4TPH1, TPH2
15positive regulation of cAMP biosynthetic processGO:0308199.4CRH, GHRH
16indolalkylamine biosynthetic processGO:0462199.4TPH2, TPH1
17circadian rhythmGO:0076239.1TPH2, TPH1
18response to drugGO:0424939.0HTR2A, CRH, TSPO, COMT
19synaptic transmissionGO:0072688.9CRH, COMT, HTR2A, TSPO
20positive regulation of cell proliferationGO:0082848.2CCK, CCKBR, HTR2A, HTR1A, GHRH, CRH

Molecular functions related to Panic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholecystokinin receptor activityGO:0049519.7CCKAR, CCKBR
2neuropeptide hormone activityGO:0051849.7CRH, CCK
3serotonin receptor activityGO:0049939.4HTR2A, HTR1A
4tryptophan 5-monooxygenase activityGO:0045109.2TPH1, TPH2
5amino acid bindingGO:0165978.8TPH1, TPH2

Products for genes affiliated with Panic Disorder

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  • Antibodies
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Sources for Panic Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet