PANIC
MCID: PNC025
MIFTS: 60

Panic Disorder (PANIC) malady

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Panic Disorder

Aliases & Descriptions for Panic Disorder:

Name: Panic Disorder 54 12 52 41 42 14 69
Panic Disorder 1 29 69
Panic Disorder Syndrome 1 13
Panic Anxiety Syndrome 12
Panic 52

Classifications:



External Ids:

OMIM 54 167870
Disease Ontology 12 DOID:594
MeSH 42 D016584
NCIt 47 C34890
ICD10 33 F41.0
UMLS 69 C0030319

Summaries for Panic Disorder

OMIM : 54 The DSM-IV (American Psychiatric Association, 1994) defines panic disorder as the spontaneous, unexpected occurrence of... (167870) more...

MalaCards based summary : Panic Disorder, also known as panic disorder 1, is related to personality disorder and schizophrenia, and has symptoms including anxiety An important gene associated with Panic Disorder is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways are Peptide ligand-binding receptors and Neuroscience. The drugs Paroxetine and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include heart, cortex and brain, and related phenotypes are Decreased viability and behavior/neurological

MedlinePlus : 41 panic disorder is a type of anxiety disorder. it causes panic attacks, which are sudden feelings of terror when there is no real danger. you may feel as if you are losing control. you may also have physical symptoms, such as fast heartbeat chest or stomach pain breathing difficulty weakness or dizziness sweating feeling hot or a cold chill tingly or numb hands panic attacks can happen anytime, anywhere, and without warning. you may live in fear of another attack and may avoid places where you have had an attack. for some people, fear takes over their lives and they cannot leave their homes. panic disorder is more common in women than men. it usually starts when people are young adults. sometimes it starts when a person is under a lot of stress. most people get better with treatment. therapy can show you how to recognize and change your thinking patterns before they lead to panic. medicines can also help. nih: national institute of mental health

Disease Ontology : 12 An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.

Wikipedia : 71 Panic disorder is an anxiety disorder characterized by recurrent unexpected panic attacks. Panic attacks... more...

Related Diseases for Panic Disorder

Diseases in the Panic Disorder family:

Panic Disorder 3 Panic Disorder 2

Diseases related to Panic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
id Related Disease Score Top Affiliating Genes
1 personality disorder 29.3 CCK COMT CRH HTR1A HTR2A MAOA
2 schizophrenia 28.2 ADORA2A CCK CCKAR COMT HTR1A HTR2A
3 panic disorder 3 12.1
4 panic disorder 2 12.0
5 anxiety disorder 11.4
6 agoraphobia 10.9
7 generalized anxiety disorder 10.4
8 social phobia 10.3
9 obsessive-compulsive disorder 10.3
10 polyneuropathy 10.2 HTR1A HTR2A
11 cholestasis-lymphedema syndrome 10.2 COMT MAOA
12 antisocial personality disorder 10.2 HTR1A HTR2A
13 strongyloidiasis 10.2 COMT MAOA SLC6A4
14 neurogenic bladder 10.2 HTR2A MAOA SLC6A4
15 aryepiglottic fold cancer 10.2 HTR1A HTR2A
16 pyromania 10.2 HTR2A MAOA SLC6A4
17 nephronophthisis 13 10.2 COMT HTR2A SLC6A4
18 tinea pedis 10.2 HTR1A MAOA SLC6A4
19 apperceptive agnosia 10.2 COMT HTR1A SLC6A4
20 conjunctival pigmentation 10.2 CRH MAOA SLC6A4
21 dry eye syndrome 10.2 HTR1A HTR2A SLC6A4
22 waardenburg's syndrome 10.2 HTR1A HTR2A SLC6A4
23 acute contagious conjunctivitis 10.2 CCK CCKAR CCKBR
24 gastrointestinal neuroendocrine benign tumor 10.1 CCK TSPO
25 primary angle-closure glaucoma 10.1 COMT HTR1A HTR2A SLC6A4
26 alexithymia 10.1
27 hypereosinophilic syndrome 10.1 MAOA POMC SLC6A4
28 abnormal pupillary function 10.1 HTR1A HTR3A
29 separation anxiety disorder 10.1
30 hypochondriasis 10.1
31 anodontia 10.1 HTR1A HTR3A SLC6A4
32 adult brainstem astrocytoma 10.1 CCKBR HTR1A MAOA PTK7 SLC6A4
33 sweat gland cancer 10.0 CCK HTR3A SLC6A4
34 intermittent squint 10.0 CRH POMC
35 cholesteatoma 10.0 CCK COMT POMC SLC6A4
36 hypoglycemia 10.0 CRH POMC SLC6A4
37 autoimmune disease of endocrine system 10.0 CRH POMC TSPO
38 siberian tick typhus 10.0 HTR1A HTR3A TSPO
39 chronic eosinophilic pneumonia 10.0 COMT CRH HTR1A MAOA SLC6A4
40 bipolar disorder 10.0
41 bartter disease 10.0 HTR2A SLC6A4 TPH2
42 paraphilia disorder 10.0 COMT HTR2A MAOA SLC6A4 TPH2
43 childhood malignant hemangiopericytoma 10.0 CCK CCKAR CRH
44 nephrogenic adenoma of the urethra 10.0 HTR3A SLC6A2 SLC6A4
45 colorectal adenocarcinoma 9.9 COMT MAOA SLC6A2 SLC6A4 TPH2
46 irritable bowel syndrome 9.9
47 ornithosis 9.9 CCK HTR3A MAOA PTK7 SLC6A4
48 asthma 9.9
49 somatoform disorder 9.9
50 thyroiditis 9.9

Graphical network of the top 20 diseases related to Panic Disorder:



Diseases related to Panic Disorder

Symptoms & Phenotypes for Panic Disorder

Symptoms by clinical synopsis from OMIM:

167870

Clinical features from OMIM:

167870

Human phenotypes related to Panic Disorder:

32
id Description HPO Frequency HPO Source Accession
1 anxiety 32 HP:0000739

GenomeRNAi Phenotypes related to Panic Disorder according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.43 HTR1A HTR3A SLC6A4
2 Decreased viability GR00381-A-3 9.43 HTR1A HTR3A SLC6A4
3 Increased transferrin (TF) endocytosis GR00363-A 9.36 HTR3A POMC PTK7 TPH2 TSPO ADORA2A

MGI Mouse Phenotypes related to Panic Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.36 HTR1A HTR2A HTR3A MAOA POMC SLC6A2
2 cardiovascular system MP:0005385 10.21 TSPO ADORA2A CCKBR COMT HTR1A MAOA
3 homeostasis/metabolism MP:0005376 10.2 CRH HTR1A HTR3A MAOA POMC SLC6A2
4 growth/size/body region MP:0005378 10.15 ADORA2A CCKAR CCKBR CRH HTR3A POMC
5 endocrine/exocrine gland MP:0005379 10.1 TSPO CCK CCKAR CCKBR COMT CRH
6 nervous system MP:0003631 10 ADORA2A CCK CCKAR CCKBR COMT CRH
7 integument MP:0010771 9.91 ADORA2A CCKBR CRH HTR3A POMC SLC6A2
8 renal/urinary system MP:0005367 9.5 PTK7 CCKAR CCKBR COMT CRH HTR3A
9 respiratory system MP:0005388 9.17 ADORA2A CCKAR COMT CRH PTK7 TPH1

Drugs & Therapeutics for Panic Disorder

Drugs for Panic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 173)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 2 61869-08-7 43815
2
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
3
Norepinephrine Approved Phase 4,Phase 3 51-41-2 439260
4
Citalopram Approved Phase 4,Phase 3,Phase 1 59729-33-8 2771
5
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
6
Sertraline Approved Phase 4,Phase 2,Phase 3,Phase 1 79617-96-2 68617
7
Alprazolam Approved, Illicit, Investigational Phase 4,Phase 2,Phase 1 28981-97-7 2118
8
Clonazepam Approved, Illicit Phase 4,Phase 2,Phase 3 1622-61-3 2802
9
Clozapine Approved Phase 4 5786-21-0 2818
10
Vortioxetine Approved Phase 4 508233-74-7 9966051
11
Risperidone Approved, Investigational Phase 4,Phase 3,Phase 2 106266-06-2 5073
12
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
13
Ziprasidone Approved Phase 4 146939-27-7 60854
14
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1 64-17-5 702
15
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
16
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
17 Antidepressive Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Antidepressive Agents, Second-Generation Phase 4,Phase 3,Phase 2,Phase 1
19 Cytochrome P-450 CYP2D6 Inhibitors Phase 4,Phase 3,Phase 2
20 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
21 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
23 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1
24
Serotonin Phase 4,Phase 3,Phase 2,Phase 1 50-67-9 5202
25 Serotonin Agents Phase 4,Phase 3,Phase 2,Phase 1
26 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
27 Anticonvulsants Phase 4,Phase 2,Phase 3,Phase 1
28 Antimanic Agents Phase 4
29 Antipsychotic Agents Phase 4,Phase 3,Phase 2
30 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
31 GABA Agents Phase 4,Phase 2,Phase 3,Phase 1
32 Quetiapine Fumarate Phase 4,Phase 2 111974-72-2
33 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Early Phase 1
35 Antiparkinson Agents Phase 4,Phase 3,Phase 1
36 Autonomic Agents Phase 4,Phase 3,Phase 1,Early Phase 1
37 Cholinergic Agents Phase 4,Phase 3,Phase 1,Early Phase 1
38 Cholinergic Antagonists Phase 4,Phase 3,Phase 1
39 Muscarinic Antagonists Phase 4,Phase 3,Phase 1
40 Parasympatholytics Phase 4,Phase 3,Phase 1
41 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
42 Analgesics Phase 4
43 Dopamine Agents Phase 4,Phase 3,Phase 2
44 Duloxetine Hydrochloride Phase 4
45 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4,Phase 3
46 Anti-Anxiety Agents Phase 4,Phase 2,Phase 1
47 GABA Modulators Phase 4,Phase 2,Phase 3,Phase 1
48 Hypnotics and Sedatives Phase 4,Phase 2,Phase 1
49 Serotonin Antagonists Phase 4,Phase 3,Phase 2
50 Serotonin 5-HT1 Receptor Agonists Phase 4

Interventional clinical trials:

(show top 50) (show all 246)
id Name Status NCT ID Phase
1 Costs of Lost Productive Time Among Korean Workers With Panic Disorder and Effect of Treatment With Paroxetine Controlled Release Unknown status NCT00492414 Phase 4
2 Quetiapine SR and Divalproex Sodium ER in the Treatment of Anxiety in Bipolar Disorder With Panic Disorder and/or GAD Unknown status NCT00579280 Phase 4
3 The Efficacy and Tolerability of Duloxetine for the Treatment of Panic Disorder Completed NCT00438971 Phase 4
4 A Study of Quetiapine SR (Seroquel SR) to Treat SSRI-Resistant, Comorbid Panic Disorder Patients Completed NCT00619892 Phase 4
5 A Study Of Sertraline Compared With Paroxetine In The Treatment Of Panic Disorder Completed NCT00677352 Phase 4
6 Paroxetine vs Placebo Combined With Aerobic Exercise or Relaxation in Panic Disorder Completed NCT00540098 Phase 4
7 Changes of Cerebral Glucose Metabolism After 12 Weeks of Paroxetine Treatment in Panic Disorder Completed NCT00767754 Phase 4
8 Changes of Cerebral Glucose Metabolism and After 12 Weeks of Escitalpram Treatment in Panic Disorder Completed NCT00767871 Phase 4
9 Efficacy of Aerobic Exercise Added to Alprazolam in Panic Disorder Treatment Completed NCT00803400 Phase 4
10 Escitalopram Trial for Irritable Bowel Syndrome (IBS) Patients With Panic Disorder Completed NCT01551225 Phase 4
11 Evaluation of Clonazepam and Paroxetine for Panic Disorder With Depression Completed NCT00031317 Phase 4
12 A 10-Week, Open-Label, Flexible Dose Adaptive Study Evaluating the Efficacy of Vortioxetine in Subjects With Panic Disorder Completed NCT02395510 Phase 4
13 Long Term Treatment of Panic Disorder With Clonazepam or Paroxetine Completed NCT02852577 Phase 4
14 Trial to Compare Time to Response in the Symptoms of Anxiety to Concomitant Treatment With Niravamâ„¢ and an SSRI or SNRI to Treatment With an SSRI or SNRI Alone in Subjects With Generalized Anxiety Disorder or Panic Disorder Completed NCT00266409 Phase 4
15 A Study of Sertraline and Early Alprazolam XR Administration Versus Sertraline Only in Panic Disorder Patients Completed NCT00198094 Phase 4
16 A Study of Risperidone Monotherapy in Bipolar Anxiety Completed NCT00167479 Phase 4
17 Aripiprazole for the Treatment of Refractory Anxiety Completed NCT00438386 Phase 4
18 Ziprasidone in Bipolar Disorder With Comorbid Lifetime Panic or Generalized Anxiety Disorder(GAD) Completed NCT01172652 Phase 4
19 The Effects of Treatment With Sertraline for Noncardiac Chest Pain Completed NCT01114100 Phase 4
20 A Collaborative Care Program to Improve Treatment of Depression and Anxiety Disorders in Cardiac Patients Completed NCT01201967 Phase 4
21 Primary Care Intervention Strategy for Anxiety Disorders Completed NCT00347269 Phase 4
22 A Double Blind, Randomized Placebo Controlled Study of the Efficacy, Safety and of Quetiapine Fumarate (Seroquel®) as Potentiation SSRI's, and SNRI's Treatment in Major Depression With Anxiety Completed NCT00229645 Phase 4
23 Paroxetine - Controlled Release in the Treatment of Irritable Bowel Syndrome (IBS) Completed NCT00610909 Phase 4
24 Trial of Seroquel SR for Alcohol Dependence and Comorbid Anxiety Completed NCT00352469 Phase 4
25 Non Cardiac Chest Pain and Benign Palpitations Completed NCT00623454 Phase 4
26 Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder Completed NCT00391430 Phase 4
27 Pharmacotherapy in Depression With Panic Spectrum Completed NCT00177996 Phase 4
28 Ketamine Infusion for Adolescent Depression and Anxiety Recruiting NCT02579928 Phase 4
29 Sertraline in Generalized Social Phobia With Co-Occurring Anxiety and Mood Disorders Active, not recruiting NCT00182533 Phase 4
30 Lisdexamfetamine Dimesylate in the Treatment of Adult ADHD With Anxiety Disorder Comorbidity Active, not recruiting NCT01863459 Phase 4
31 Alcohol Research Consortium in HIV-Intervention Research Arm Not yet recruiting NCT02938377 Phase 4
32 A Study to Evaluate the Use of Extended Release Alprazolam in the Treatment of Adolescents With Panic Disorder Terminated NCT00635531 Phase 4
33 A Study to Assess the Long-Term Use of Alprazolam Extended Release (XL) in the Treatment of Adolescents With Panic Disorder Terminated NCT00635076 Phase 4
34 A Study To Assess the Safety of Extended Release Alprazolam for the Treatment of Adolescents With Panic Disorder or Anxiety With Panic Attacks Terminated NCT00634790 Phase 4
35 Mechanisms of Panic Disorders Treatment Unknown status NCT01323556 Phase 2, Phase 3
36 Psychotherapy Outcome and Self-selection Effects in Panic Disorder Unknown status NCT01606592 Phase 2, Phase 3
37 Study Comparing Venlafaxine vs. Paroxetine in Panic Disorder Completed NCT00195598 Phase 3
38 Psychodynamic Therapy for Treating Panic Disorder Completed NCT00128388 Phase 2, Phase 3
39 Therapies for Treatment-Resistant Panic Disorder Symptoms Completed NCT00118417 Phase 2, Phase 3
40 Internet-Versus Group-Administered Cognitive Behavior Therapy for Panic Disorder Completed NCT00845260 Phase 3
41 Comparison of Psychotherapy Programs to Treat Panic Disorder Completed NCT00353470 Phase 3
42 Treatment of Panic Disorder: Long Term Strategies Completed NCT00000368 Phase 3
43 Study Evaluating Venlafaxine ER in Patients With Panic Disorder Completed NCT00044772 Phase 3
44 Study Evaluating Venlafaxine ER in Adults With Panic Disorder Completed NCT00038896 Phase 3
45 Levetiracetam Treatment of Panic Disorder and Lactate-Induced Panic Attacks Completed NCT00279617 Phase 3
46 Treatment of Social Phobia and Panic Disorder in Adults Completed NCT00619138 Phase 3
47 Virtual Reality Exposure Therapy in Agoraphobic Participants Completed NCT00734370 Phase 2, Phase 3
48 Improving Quality of Primary Care for Patients With Anxiety and/or Panic Disorders Completed NCT00102427 Phase 2, Phase 3
49 Telephone-Based Care Management Program for Individuals With Anxiety Disorders Completed NCT00158327 Phase 3
50 Study of Risperidone Monotherapy in Ambulatory Bipolar Disorder With Concurrent Moderately Severe Anxiety and Lifetime Panic or Generalized Anxiety Disorder Completed NCT00277654 Phase 3

Search NIH Clinical Center for Panic Disorder

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: panic disorder

Genetic Tests for Panic Disorder

Genetic tests related to Panic Disorder:

id Genetic test Affiliating Genes
1 Panic Disorder 1 29

Anatomical Context for Panic Disorder

MalaCards organs/tissues related to Panic Disorder:

39
Heart, Cortex, Brain, Amygdala, Testes, Prefrontal Cortex, Cingulate Cortex

Publications for Panic Disorder

Articles related to Panic Disorder:

(show top 50) (show all 1199)
id Title Authors Year
1
Mental health service use, depression, panic disorder and life events among Swedish young adults in 2000 and 2010: a repeated cross-sectional population study in Stockholm County, Sweden. ( 28367775 )
2017
2
Side Effects to Antidepressant Treatment in Patients With Depression and Comorbid Panic Disorder. ( 28068460 )
2017
3
Contribution of Group Therapeutic Factors to the Outcome of Cognitive-Behavioral Therapy for Patients with Panic Disorder. ( 28359425 )
2017
4
Reduction in Costs after Treating Comorbid Panic Disorder with Agoraphobia and Generalized Anxiety Disorder. ( 28418834 )
2017
5
Burden and Distress in Caregivers of Patients With Panic Disorder and Agoraphobia. ( 27861457 )
2017
6
Does patient reluctance towards exposure and psychologists' attitudes about evidence based practice influence treatment recommendations for panic disorder? An experimental investigation. ( 28325630 )
2017
7
Psychoticism in patients with panic disorder with or without comorbid agoraphobia. ( 28345374 )
2017
8
Perceived criticism predicts outcome of psychotherapy for panic disorder: Replication and extension. ( 28045286 )
2017
9
The development and validation of static and adaptive screeners to measure the severity of panic disorder, social anxiety disorder, and obsessive compulsive disorder. ( 28370638 )
2017
10
Erratum to: Effects of Mental Stress Induction on Heart Rate Variability in Patients with Panic Disorder. ( 28357597 )
2017
11
Quality of Life in Patients with Coronary Artery Disease and Panic Disorder: A Comparative Study. ( 28042398 )
2017
12
Association between personality traits and Escitalopram treatment efficacy in panic disorder. ( 28472591 )
2017
13
Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia. ( 28331799 )
2017
14
Translational approach to the pathophysiology of panic disorder: Focus on serotonin and endogenous opioids. ( 28073587 )
2017
15
Functional neuroanatomy in panic disorder: Status quo of the research. ( 28401046 )
2017
16
Panic Disorder Comorbidity with Medical Conditions and Treatment Implications. ( 28375724 )
2017
17
The indirect effect of panic disorder on smoking cognitions via difficulties in emotion regulation. ( 28395248 )
2017
18
Red Blood Cell and Platelet Indices: A Potential Biomarker for Panic Disorder. ( 28479785 )
2017
19
Impact of childhood trauma on course of panic disorder: contribution of clinical and personality characteristics. ( 28369890 )
2017
20
Distinct phasic and sustained brain responses and connectivity of amygdala and bed nucleus of the stria terminalis during threat anticipation in panic disorder. ( 28485259 )
2017
21
Cardiac sarcoidosis resembling panic disorder: a case report. ( 28086847 )
2017
22
Modeling the development of panic disorder with interoceptive conditioning. ( 27887860 )
2017
23
Mean Platelet Volume and Platelet Distribution Width Level in Patients with Panic Disorder. ( 28479788 )
2017
24
Sudden gains in exposure-focused cognitive-behavioral group therapy for panic disorder. ( 28493541 )
2017
25
Basic Self-Disturbances beyond Schizophrenia: Discrepancies and Affinities in Panic Disorder - An Empirical Clinical Study. ( 28259879 )
2017
26
Natriuretic Peptides in Anxiety and Panic Disorder. ( 28061968 )
2017
27
White matter microstructural changes are associated with alcohol use in patients with panic disorder. ( 27085658 )
2016
28
Factors associated with pain level in non-cardiac chest pain patients with comorbid panic disorder. ( 27777612 )
2016
29
MAOA gene hypomethylation in panic disorder-reversibility of an epigenetic risk pattern by psychotherapy. ( 27045843 )
2016
30
Correction: Predicting Response Trajectories during Cognitive-Behavioural Therapy for Panic Disorder: No Association with the BDNF Gene or Childhood Maltreatment. ( 27907177 )
2016
31
Serotonin Transporter and COMT Polymorphisms as Independent Predictors of Health-related Quality of Life in Patients with Panic Disorder. ( 27134498 )
2016
32
Threat expectancy bias and treatment outcome in patients with panic disorder and agoraphobia. ( 27061246 )
2016
33
Comorbid panic disorder as an independent risk factor for suicide attempts in depressed outpatients. ( 27095329 )
2016
34
Insomnia Symptoms Following Treatment for Comorbid Panic Disorder With Agoraphobia and Generalized Anxiety Disorder. ( 27019339 )
2016
35
Mobilization of Peripheral Blood Stem Cells and Changes in the Concentration of Plasma Factors Influencing their Movement in Patients with Panic Disorder. ( 27914035 )
2016
36
The role of treatment delivery factors in exposure-based cognitive behavioral therapy for panic disorder with agoraphobia. ( 27235836 )
2016
37
Agoraphobia Related to Unassertiveness in Panic Disorder. ( 26915016 )
2016
38
Assessment of automatic associations with bodily sensations and agoraphobic situations in panic disorder. ( 27085983 )
2016
39
Psychotherapies for Panic Disorder: A Tale of Two Sites. ( 27464313 )
2016
40
Psychological dependence on antidepressants in patients with panic disorder: a cross-sectional study. ( 27496597 )
2016
41
Cortisol awakening response in drug-naA^ve panic disorder. ( 27390521 )
2016
42
A CASE OF ADVANCED NON-SEMINOMATOUS TESTICULAR GERM CELL TUMOR ACCOMPANIED PANIC DISORDER. ( 28132992 )
2016
43
Developmental risk factors in generalized anxiety disorder and panic disorder. ( 27466747 )
2016
44
Personality Disorders in Hypochondriasis: A Comparison to Panic Disorder and Healthy Controls. ( 27749185 )
2016
45
Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population. ( 27081567 )
2016
46
Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults. ( 27730622 )
2016
47
Predictors of Dropout From Cognitive-Behavioral Group Treatment for Panic Disorder With Agoraphobia: An Exploratory Study. ( 27385412 )
2016
48
Predisposition or side effect of the duration: the reactivity of the HPA-axis under psychosocial stress in panic disorder. ( 27354161 )
2016
49
Relative effects of cognitive and behavioral therapies on generalized anxiety disorder, social anxiety disorder and panic disorder: A meta-analysis. ( 27637075 )
2016
50
Association between genes on chromosome 19p13.2 and panic disorder. ( 27610895 )
2016

Variations for Panic Disorder

Expression for Panic Disorder

Search GEO for disease gene expression data for Panic Disorder.

Pathways for Panic Disorder

Pathways related to Panic Disorder according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.36 ADORA2A CCK CCKAR CCKBR CRH HTR1A
2 12.37 COMT HTR1A POMC TPH1 TPH2
3
Show member pathways
12.07 ADORA2A CCKAR CCKBR HTR2A
5 11.91 HTR1A HTR2A HTR3A MAOA SLC6A4 TPH1
6 11.74 ADORA2A CCKBR HTR2A
7 11.55 HTR1A HTR2A HTR3A MAOA SLC6A4 TPH1
8
Show member pathways
11.33 COMT SLC6A2 SLC6A4
9
Show member pathways
11.29 ADORA2A MAOA SLC6A2 SLC6A4 TPH2
10
Show member pathways
11.01 COMT MAOA SLC6A4
11
Show member pathways
10.89 COMT MAOA TPH1
12 10.69 COMT MAOA
13
Show member pathways
10.68 COMT MAOA
14 10.64 CCK CCKBR
15 10.61 HTR1A HTR2A HTR3A MAOA SLC6A4 TPH1
16 10.36 CRH POMC

GO Terms for Panic Disorder

Cellular components related to Panic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.67 ADORA2A CCK COMT HTR2A
2 neuron projection GO:0043005 9.62 SLC6A2 SLC6A4 TPH1 TPH2
3 integral component of plasma membrane GO:0005887 9.56 ADORA2A CCKAR CCKBR HTR1A HTR2A PTK7
4 neuronal cell body GO:0043025 9.55 ADORA2A CCK CRH HTR2A HTR3A
5 axon GO:0030424 9.02 ADORA2A CCK COMT HTR2A HTR3A
6 integral component of membrane GO:0016021 10.03 ADORA2A CCKAR CCKBR COMT HTR1A HTR2A

Biological processes related to Panic Disorder according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.97 CCK CCKBR CRH HTR1A HTR2A
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.81 CCKAR CCKBR HTR2A
3 circadian rhythm GO:0007623 9.78 SLC6A4 TPH1 TPH2
4 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 9.71 CCKAR CCKBR HTR2A
5 response to immobilization stress GO:0035902 9.64 CRH TPH1
6 adrenal gland development GO:0030325 9.63 CRH TSPO
7 vasoconstriction GO:0042310 9.62 HTR1A SLC6A4
8 synaptic transmission, dopaminergic GO:0001963 9.62 ADORA2A CRH
9 sensory perception GO:0007600 9.61 ADORA2A CCKBR
10 behavior GO:0007610 9.6 HTR1A HTR2A
11 neurotransmitter catabolic process GO:0042135 9.59 COMT MAOA
12 catecholamine metabolic process GO:0006584 9.58 COMT MAOA
13 positive regulation of mitochondrial depolarization GO:0051901 9.58 CCK TSPO
14 regulation of behavior GO:0050795 9.56 HTR1A HTR2A
15 monoamine transport GO:0015844 9.55 SLC6A2 SLC6A4
16 dopamine catabolic process GO:0042420 9.52 COMT MAOA
17 positive regulation of glutamate secretion GO:0014049 9.51 ADORA2A CCK
18 response to drug GO:0042493 9.5 ADORA2A COMT CRH HTR2A SLC6A2 SLC6A4
19 aromatic amino acid family metabolic process GO:0009072 9.49 TPH1 TPH2
20 dopamine uptake involved in synaptic transmission GO:0051583 9.48 SLC6A2 SLC6A4
21 indolalkylamine biosynthetic process GO:0046219 9.46 TPH1 TPH2
22 serotonin biosynthetic process GO:0042427 9.43 TPH1 TPH2
23 serotonin receptor signaling pathway GO:0007210 9.43 HTR1A HTR2A HTR3A
24 regulation of serotonin secretion GO:0014062 9.4 CRH HTR1A
25 cholecystokinin signaling pathway GO:0038188 9.37 CCKAR CCKBR
26 regulation of hormone secretion GO:0046883 9.33 CCKAR HTR1A HTR2A
27 response to pain GO:0048265 8.92 COMT CRH SLC6A2 TSPO
28 signal transduction GO:0007165 10.02 ADORA2A CCK CCKAR CCKBR CRH HTR1A

Molecular functions related to Panic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.8 ADORA2A CCKAR CCKBR HTR1A HTR2A
2 hormone activity GO:0005179 9.63 CCK CRH POMC
3 amino acid binding GO:0016597 9.48 TPH1 TPH2
4 monoamine transmembrane transporter activity GO:0008504 9.43 SLC6A2 SLC6A4
5 G-protein coupled serotonin receptor activity GO:0004993 9.43 HTR1A HTR2A HTR3A
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GO:0016714 9.37 TPH1 TPH2
7 dopamine:sodium symporter activity GO:0005330 9.32 SLC6A2 SLC6A4
8 tryptophan 5-monooxygenase activity GO:0004510 9.16 TPH1 TPH2
9 cholecystokinin receptor activity GO:0004951 8.96 CCKAR CCKBR
10 serotonin binding GO:0051378 8.8 HTR1A HTR2A HTR3A

Sources for Panic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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