PANIC
MCID: PNC025
MIFTS: 65

Panic Disorder (PANIC) malady

Neuronal diseases category

Summaries for Panic Disorder

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Panic disorder is a type of anxiety disorder. it causes panic attacks, which are sudden feelings of terror when there is no real danger. you may feel as if you are losing control. you may also have physical symptoms, such as fast heartbeat chest or stomach pain breathing difficulty weakness or dizziness sweating feeling hot or a cold chill tingly or numb hands panic attacks can happen anytime, anywhere, and without warning. you may live in fear of another attack and may avoid places where you have had an attack. for some people, fear takes over their lives and they cannot leave their homes. panic disorder is more common in women than men. it usually starts when people are young adults. sometimes it starts when a person is under a lot of stress. most people get better with treatment. therapy can show you how to recognize and change your thinking patterns before they lead to panic. medicines can also help. nih: national institute of mental health

MalaCards: Panic Disorder, also known as panic anxiety syndrome, is related to agoraphobia and anxiety disorder. An important gene associated with Panic Disorder is COMT (catechol-O-methyltransferase), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The compounds dopamine and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and cortex, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.

Wikipedia:63 Panic disorder is an anxiety disorder characterized by recurring severe panic attacks. It may also... more...

Description from OMIM:46 167870

Aliases & Classifications for Panic Disorder

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

panic disorder 8 46 10 44 33
panic anxiety syndrome 8
panic disorder 1 60
panic 44


External Ids:

Disease Ontology8 DOID:594
MeSH34 D016584
NCIt39 C34890
ICD1025 F41.0

Related Diseases for Panic Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Panic Disorder family:

Panic Disorder 3 Panic Disorder 2
Panic Disorder Syndrome 1

Diseases related to Panic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1agoraphobia31.8CCKBR, HTR1A, MAOA, SLC6A2, PTK7
2anxiety disorder31.4CRH, MAOA, SLC6A4, TPH1, TPH2
3generalized anxiety disorder31.0TSPO, SLC6A4, HTR1A
4personality disorder31.0MAOA, SLC6A4, TPH1, TPH2
5social phobia31.0COMT, HTR1A, MAOA, SLC6A4
6obsessive-compulsive disorder30.9SLC6A2, TSPO, TPH1, TPH2, SLC6A4, MAOA
7bipolar disorder30.6HTR2A, SLC6A4
8schizophrenia30.6HTR2A, COMT
9irritable bowel syndrome30.5CCK, CRH, SLC6A4, TPH1
10thyroiditis30.4TRH
11mood disorder30.3SLC6A4, SLC6A2, TPH1, TPH2, MAOA, TRH
12migraine30.3COMT, HTR1A, HTR2A, MAOA, SLC6A4, TPH1
13eating disorder30.2SLC6A4, COMT, CCKAR, CCK, HTR1A, HTR2A
14conduct disorder30.2SLC6A4, MAOA, COMT
15substance dependence30.2COMT, SLC6A4, TPH1
16hypertension30.2SLC6A4, CRH
17alcohol abuse30.2COMT, SLC6A4
18dysthymic disorder30.2HTR2A, MAOA
19asthma30.2HTR2A, TSPO, ADORA2A
20psychotic disorder29.9CCK, HTR1A, HTR2A, MAOA, SLC6A4, TPH1
21attention deficit hyperactivity disorder29.9COMT, HTR2A, MAOA, SLC6A4, SLC6A2, TPH2
22seasonal affective disorder29.9HTR1A, HTR2A, CRH, SLC6A4, TPH1
23alcohol dependence29.9HTR2A, CRH, MAOA, SLC6A4
24borderline personality disorder29.9MAOA, SLC6A4, TPH1
25substance abuse29.9CRH, SLC6A4
26essential hypertension29.9COMT, HTR2A, SLC6A2, ADORA2A
27hyperprolactinemia29.9TRH, GHRH, CRH
28nicotine dependence29.9SLC6A4
29breast cancer29.9GHRH, COMT
30premature ejaculation29.9SLC6A4, HTR1A
31major depressive disorder10.8
32separation anxiety disorder10.5
33alexithymia10.4
34physical disorder10.4
35mitral valve prolapse10.4
36hypochondriasis10.4
37pain disorder10.4
38dissociative disorder10.4
39somatoform disorder10.4
40specific phobia10.4
41sleep disorder10.3
42withdrawal disorder10.3
43neuronitis10.3
44hypophosphatemia10.2
45somatization disorder10.2
46post-traumatic stress disorder10.2
47hypermobility syndrome10.2
48panic disorder 310.2
49panic disorder 210.2
50coronary artery disease10.1

Graphical network of the top 20 diseases related to Panic Disorder:



Diseases related to panic disorder

Clinical Features for Panic Disorder

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Sources:
46OMIM
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Clinical features from OMIM:

167870

Clinical synopsis from OMIM:

167870

Drugs & Therapeutics for Panic Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Panic Disorder

Drug clinical trials:

Search ClinicalTrials for Panic Disorder

Search NIH Clinical Center for Panic Disorder

Search CenterWatch for Panic Disorder

Genetic Tests for Panic Disorder

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Anatomical Context for Panic Disorder

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32MalaCards
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MalaCards organs/tissues related to Panic Disorder:

32
Heart, Brain, Cortex, Testes, Prefrontal cortex, Amygdala, Cingulate cortex, Pituitary, Thyroid, Hypothalamus, T cells, Skin, Breast, Lung, Eye

Animal Models for Panic Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Panic Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.9TPH2, COMT, CCKAR, CCKBR, CCK, HTR1A
2MP:000538610.9HTR2A, HTR1A, CCKBR, CCKAR, COMT, CRH
3MP:000537610.9CRH, HTR1A, CCK, CCKBR, CCKAR, COMT
4MP:000537810.7CCKAR, CCKBR, CRH, GHRH, TRH, SLC6A4
5MP:001077110.6CRH, SLC6A4, SLC6A2, ADORA2A, TPH1, TPH2
6MP:000537910.6CCKAR, CCKBR, CCK, HTR2A, CRH, GHRH
7MP:000538510.4COMT, CCKBR, HTR1A, MAOA, SLC6A4, PTK7

Publications for Panic Disorder

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Sources:
50PubMed
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Articles related to Panic Disorder:

(show top 50)    (show all 1057)
idTitleAuthorsYear
1
Clinical experiences in using cognitive-behavior therapy to treat panic disorder. (24411112)
2014
2
Using brain imaging to understand the response to cognitive therapy in panic disorder. (24185237)
2013
3
Smoking, physical activity and respiratory irregularities in patients with panic disorder. (24056828)
2013
4
Cluster A personality pathology in social anxiety disorder: A comparison with panic disorder. (24320019)
2013
5
Circadian Blood Pressure Variation in Normotensive Patients With Panic Disorder. (24280264)
2013
6
Two-year course of generalized anxiety disorder, social anxiety disorder, and panic disorder in a longitudinal sample of African American adults. (24041233)
2013
7
Alpha absolute power measurement in panic disorder with agoraphobia patients. (23820098)
2013
8
How specific are inhibitory deficits to obsessive-compulsive disorder? A neurophysiological comparison with panic disorder. (24079948)
2013
9
Comparison of panic disorder with and without comorbid major depression by using brain structural magnetic resonance imaging. (23313294)
2013
10
Associations between prefrontal I^-aminobutyric acid concentration and the tryptophan hydroxylase isoform 2 gene, a panic disorder risk allele in women. (23552096)
2013
11
Rate of improvement during and across three treatments for panic disorder with or without agoraphobia: cognitive behavioral therapy, selective serotonin reuptake inhibitor or both combined. (23676529)
2013
12
Changes in automatic threat processing precede and predict clinical changes with exposure-based cognitive-behavior therapy for panic disorder. (23510582)
2013
13
Improvements in white matter micro-structural integrity of right uncinate fasciculus and left fronto-occipital fasciculus of remitted first-episode medication-naA^ve panic disorder patients. (23680435)
2013
14
Rare variants in TMEM132D in a case-control sample for panic disorder. (22911938)
2012
15
Distinct panicogenic activity of sodium lactate and cholecystokinin tetrapeptide in patients with panic disorder. (22632477)
2012
16
Panic disorder in rural Tanzania: an explorative study. (22344762)
2012
17
Panic disorder and subthreshold panic in the light of comorbidity: a follow-up study. (22425529)
2012
18
Imipramine for vestibular dysfunction in panic disorder: a prospective case series. (21537560)
2011
19
Panic attacks and panic disorder in a population-based sample of active Canadian military personnel. (21272515)
2011
20
Pituitary volume in patients with panic disorder. (21075158)
2011
21
The efficacy and safety of alprazolam versus other benzodiazepines in the treatment of panic disorder. (21869686)
2011
22
Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR). (18663369)
2010
23
Increased opioid dependence in a mouse model of panic disorder. (20204153)
2010
24
Imipramine on the treatment of chronic dizziness and panic disorder--3 cases report. (20307620)
2010
25
No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population. (19461660)
2009
26
Panic disorder and social anxiety disorder subtypes in a caffeine challenge test. (19698996)
2009
27
Effects of the GABA-reuptake inhibitor tiagabine on panic and anxiety in patients with panic disorder. (19924586)
2009
28
Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder. (19319993)
2009
29
A randomized, controlled clinical trial of standard, group and brief cognitive-behavioral therapy for panic disorder with agoraphobia: a two-year follow-up. (19709851)
2009
30
Predictors of clinical improvement in a randomized effectiveness trial for primary care patients with panic disorder. (19829198)
2009
31
Differential familial liability of panic disorder and agoraphobia. (18023003)
2008
32
Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor. (17613943)
2007
33
Efficacy of cognitive-behavioral therapy for comorbid panic disorder with agoraphobia and generalized anxiety disorder. (17699121)
2007
34
Panic disorder and the onset of agoraphobia. (16732761)
2006
35
Interaction of serotonergic and noradrenergic gene variants in panic disorder. (16538182)
2006
36
Norepinephrine transporter (NET) promoter and 5'-UTR polymorphisms: association analysis in panic disorder. (15722184)
2005
37
Prediction of outcome in the behavioural treatment of panic disorder with agoraphobia. (15625791)
2004
38
Heightened embarrassability discriminates between panic disorder patients with and without agoraphobia. (14972667)
2003
39
Norepinephrine transporter gene (NET) variants in patients with panic disorder. (12401556)
2002
40
EMDR for panic disorder with agoraphobia: comparison with waiting list and credible attention-placebo control conditions. (11142547)
2000
41
Attention fixation training: training people to form cognitive maps help to control symptoms of panic disorder with agoraphobia. (10759324)
1999
42
Effect of a novel environment on resting heart rate in panic disorder. (9750976)
1998
43
Cognitive-behavioral treatment of panic disorder with agoraphobia triggered by AICD implant activity. (9775709)
1998
44
Respiratory training prior to exposure in vivo in the treatment of panic disorder with agoraphobia: efficacy and predictors of outcome. (7625959)
1995
45
Provocative agents in panic disorder. (7482384)
1995
46
Assessing the efficacy of treatments for panic disorder and agoraphobia. I. Methodological problems. (7673660)
1995
47
Comparison of personality disorders in different anxiety disorder diagnoses: panic, agoraphobia, generalized anxiety, and social phobia. (7804388)
1994
48
Overprediction of fear in panic disorder patients with agoraphobia: does the (mis)match model generalize to exposure in vivo therapy? (7980358)
1994
49
Remission and relapse in subjects with panic disorder and panic with agoraphobia: a prospective short-interval naturalistic follow-up. (10678311)
1994
50
Panic disorder and agoraphobia. Nondrug treatment options for primary care physicians. (2381882)
1990

Genetic Variations for Panic Disorder

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Expression for genes affiliated with Panic Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Panic Disorder

Search GEO for disease gene expression data for Panic Disorder.

Pathways for genes affiliated with Panic Disorder

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB
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Pathways related to Panic Disorder according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7ADORA2A, CCKAR, CCKBR, CCK, HTR1A, HTR2A
2
Hide members
10.7CCKAR, CCKBR, CCK, HTR1A, HTR2A, CRH
310.6HTR1A, HTR2A, MAOA, SLC6A4, TPH1, TPH2
4
Hide members
10.6COMT, HTR1A, HTR2A, MAOA, SLC6A4
5
Hide members
10.6CCKAR, CCKBR, CCK, HTR2A, TRH
610.6CCKAR, CCKBR, HTR2A, ADORA2A
7
Hide members
10.6SLC6A4, MAOA, HTR2A, HTR1A
810.6SLC6A4, SLC6A2, ADORA2A, TPH2
910.5ADORA2A, HTR2A, CCKBR
10
Hide members
10.5MAOA, TPH1, TPH2
11
Hide members
10.5TPH2, TPH1, MAOA
12
Hide members
10.5MAOA, COMT
13
Hide members
10.5SLC6A2, SLC6A4
14
Hide members
10.5TPH2, TPH1
15
Hide members
10.5TPH1, TPH2
16
Hide members
10.5TPH2, TPH1

Compounds for genes affiliated with Panic Disorder

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Panic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 267)
idCompoundScoreTop Affiliating Genes
1dopamine44 28 11 2414.3COMT, TPH1, CCKAR, CCKBR, CCK, ADORA2A
2norepinephrine44 11 2413.2GHRH, CRH, HTR2A, HTR1A, CCK, COMT
35-hydroxytryptamine4411.2TSPO, SLC6A2, SLC6A4, MAOA, CRH, HTR2A
4gaba4411.2TPH1, ADORA2A, TSPO, PTK7, SLC6A2, SLC6A4
5cocaine44 1112.1TRH, CRH, CCK, CCKBR, CCKAR, COMT
6glutamate4411.1COMT, CCKBR, CCK, CRH, TRH, MAOA
7haloperidol44 28 2 49 1115.1CCKAR, CCKBR, HTR1A, HTR2A, SLC6A4, SLC6A2
8benzodiazepine4411.1TSPO, PTK7, MAOA, CCK, CCKBR, CCKAR
9fenfluramine28 44 1113.1CCK, HTR1A, HTR2A, CRH, GHRH, TPH2
10fluoxetine49 44 28 1114.1TPH2, TPH1, SLC6A2, HTR1A, HTR2A, CRH
11maoa4411.1COMT, SLC6A2, TPH2, TPH1, SLC6A4, MAOA
12citalopram49 44 11 2414.1TPH1, PTK7, SLC6A2, SLC6A4, MAOA, HTR2A
13levodopa44 1112.1TSPO, TPH1, ADORA2A, COMT, MAOA, TRH
14clomipramine44 49 1113.1TSPO, SLC6A2, SLC6A4, MAOA, CRH, HTR1A
15acetylcholine44 49 28 11 2415.1CCK, CRH, TRH, CCKBR, TPH1, ADORA2A
16fluvoxamine44 49 1113.1HTR1A, HTR2A, SLC6A4, SLC6A2, TSPO, TPH1
17nicotine44 49 28 1114.1MAOA, CRH, SLC6A4, SLC6A2, TPH1, CCKBR
18paroxetine44 49 28 1114.0SLC6A2, COMT, HTR1A, HTR2A, MAOA, SLC6A4
19desipramine44 49 1113.0MAOA, TRH, SLC6A2, CRH, HTR2A, SLC6A4
205-hydroxytryptophan4411.0PTK7, TPH1, CRH, SLC6A4, HTR2A, HTR1A
21homovanillic acid44 2412.0SLC6A2, SLC6A4, CRH, COMT, MAOA, TPH1
22amine4411.0ADORA2A, TRH, SLC6A4, COMT, MAOA, SLC6A2
23benzodiazepines4411.0TSPO, CCKAR, CCKBR, CCK, MAOA
24amphetamine44 1112.0CCKBR, CCK, SLC6A4, SLC6A2, TPH1, MAOA
25mptp4411.0ADORA2A, SLC6A2, MAOA, COMT, SLC6A4, TSPO
26mdma4411.0MAOA, SLC6A4, HTR1A, SLC6A2, TPH1
27mhpg4411.0COMT, MAOA, SLC6A4, SLC6A2, CRH
28octreotide44 59 28 1114.0CCKBR, CCKAR, CCK, CRH, GHRH, TRH
29mianserin28 44 1112.9HTR2A, HTR1A, MAOA, SLC6A4, SLC6A2
30sertraline44 28 49 11 2414.9HTR1A, CRH, SLC6A2, SLC6A4, MAOA
31opiate4410.9ADORA2A, CRH, CCK, SLC6A4, TSPO, GHRH
32venlafaxine49 44 11 2413.9SLC6A2, SLC6A4, HTR1A, HTR2A, TPH2
33propranolol44 28 49 11 2414.9COMT, HTR1A, CRH, PTK7, TSPO, GHRH
34acth4410.9CCKBR, CCK, HTR1A, CRH, GHRH, TRH
355-hydroxyindoleacetic acid44 2411.9SLC6A2, TPH1, MAOA, CRH, SLC6A4
36carbon-114410.9SLC6A4, MAOA, HTR1A, TSPO
37p-chloroamphetamine4410.9SLC6A4, SLC6A2, MAOA, HTR1A
38morphine44 49 28 1113.8COMT, CCK, TRH, CCKAR, CCKBR, TSPO
39MMDA1110.8SLC6A2, SLC6A4, MAOA, HTR2A
40estrogen4410.8TSPO, TPH1, TPH2, SLC6A2, SLC6A4, MAOA
41spec-t4410.8CRH, SLC6A4, TSPO, ADORA2A, SLC6A2
42d amphetamine4410.8SLC6A4, SLC6A2, TSPO, MAOA
43raclopride44 2811.8CCKBR, CCK, HTR1A, HTR2A
44amitriptyline44 49 28 1113.8SLC6A4, MAOA, SLC6A2, HTR2A, HTR1A
45bromocriptine28 44 1112.7HTR1A, COMT, HTR2A, GHRH, TRH
46naloxone44 49 28 1113.7CCK, TRH, TSPO, CRH, GHRH
47nmda44 2811.6CCKBR, COMT, MAOA, TSPO, ADORA2A, HTR1A
48escitalopram44 49 11 2413.6HTR2A, SLC6A2, HTR1A, SLC6A4
49methamphetamine44 49 1112.5SLC6A4, MAOA, TPH1, SLC6A2, COMT
50antidepressants4910.3HTR1A, HTR2A, TPH1, TPH2

GO Terms for genes affiliated with Panic Disorder

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Sources:
16Gene Ontology
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Cellular components related to Panic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.7ADORA2A, PTK7, SLC6A2, SLC6A4, HTR2A, HTR1A

Biological processes related to Panic Disorder according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1response to drugGO:04249311.0ADORA2A, TSPO, SLC6A4, CRH, HTR2A, COMT
2positive regulation of cell proliferationGO:00828411.0GHRH, CRH, HTR2A, HTR1A, CCK, CCKBR
3response to painGO:04826510.9COMT, CRH, SLC6A2
4eating behaviorGO:04275510.9CCK, TRH, ADORA2A
5feeding behaviorGO:00763110.9CCKAR, CCKBR, CRH
6regulation of serotonin secretionGO:01406210.9CRH, HTR1A
7cholecystokinin signaling pathwayGO:03818810.9CCKBR, CCKAR
8regulation of hormone secretionGO:04688310.8HTR1A, HTR2A
9synaptic transmissionGO:00726810.8COMT, HTR2A, CRH, MAOA, SLC6A2
10serotonin biosynthetic processGO:04242710.8TPH1, TPH2
11dopamine catabolic processGO:04242010.8COMT, MAOA
12aromatic amino acid family metabolic processGO:00907210.8TPH1, TPH2
13circadian rhythmGO:00762310.8TPH2, TPH1, SLC6A4
14response to immobilization stressGO:03590210.8CRH, TPH1
15indolalkylamine biosynthetic processGO:04621910.7TPH2, TPH1
16positive regulation of mitochondrial depolarizationGO:05190110.7CCK, TSPO
17monoamine transportGO:01584410.7SLC6A4, SLC6A2
18neurotransmitter catabolic processGO:04213510.7MAOA, COMT
19sensory perceptionGO:00760010.6CCKBR, ADORA2A
20serotonin receptor signaling pathwayGO:00721010.6HTR1A, HTR2A
21regulation of behaviorGO:05079510.5HTR1A, HTR2A
22vasoconstrictionGO:04231010.5SLC6A4, HTR1A
23synaptic transmission, dopaminergicGO:00196310.4CRH, ADORA2A
24neurotransmitter biosynthetic processGO:04213610.2MAOA, COMT

Molecular functions related to Panic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00518410.5TRH, CRH, CCK
2monoamine transmembrane transporter activityGO:00850410.5SLC6A2, SLC6A4
3tryptophan 5-monooxygenase activityGO:00451010.4TPH2, TPH1
4cholecystokinin receptor activityGO:00495110.2CCKBR, CCKAR

Products for genes affiliated with Panic Disorder

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  • Antibodies
  • Proteins
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Sources for Panic Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet