PANIC
MCID: PNC025
MIFTS: 69

Panic Disorder (PANIC) malady

Mental diseases category
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Summaries for Panic Disorder

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MedlinePlus:33 Panic disorder is a type of anxiety disorder. it causes panic attacks, which are sudden feelings of terror when there is no real danger. you may feel as if you are losing control. you may also have physical symptoms, such as fast heartbeat chest or stomach pain breathing difficulty weakness or dizziness sweating feeling hot or a cold chill tingly or numb hands panic attacks can happen anytime, anywhere, and without warning. you may live in fear of another attack and may avoid places where you have had an attack. for some people, fear takes over their lives and they cannot leave their homes. panic disorder is more common in women than men. it usually starts when people are young adults. sometimes it starts when a person is under a lot of stress. most people get better with treatment. therapy can show you how to recognize and change your thinking patterns before they lead to panic. medicines can also help. nih: national institute of mental health

MalaCards based summary: Panic Disorder, also known as panic anxiety syndrome, is related to agoraphobia and generalized anxiety disorder, and has symptoms including An important gene associated with Panic Disorder is COMT (catechol-O-methyltransferase), and among its related pathways are Biogenic Amine Synthesis and Monoamine GPCRs. The drugs alprazolam and clonazepam and the compounds cholecystokinin tetrapeptide and asperlicin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and cortex, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Disease Ontology:8 An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.

Wikipedia:65 Panic disorder is an anxiety disorder characterized by recurring panic attacks. It may also include... more...

Description from OMIM:46 167870

Aliases & Classifications for Panic Disorder

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Panic Disorder, Aliases & Descriptions:

Name: Panic Disorder 8 46 10 44 33
Panic Anxiety Syndrome 8 62
 
Panic Disorder 1 62
Panic 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:594
NCIt39 C34890
MeSH34 D016584
ICD1025 F41.0

Related Diseases for Panic Disorder

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Diseases in the Panic Disorder family:

Panic Disorder 3 Panic Disorder 2
Panic Disorder Syndrome 1

Diseases related to Panic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1agoraphobia32.3CCKBR, HTR1A, PTK7
2generalized anxiety disorder31.6TSPO, HTR1A
3social phobia31.6COMT, HTR1A
4schizophrenia31.0COMT, HTR2A
5personality disorder30.8TPH1, TPH2
6irritable bowel syndrome30.7TPH1, CRH, CCK
7substance dependence30.5COMT, TPH1
8bipolar disorder30.3HTR2A, HTR1A, CRH, TPH1
9hyperprolactinemia30.3GHRH, CRH
10migraine30.2COMT, HTR1A, HTR2A, TPH1
11obsessive-compulsive disorder30.1TPH2, TPH1, TSPO, HTR1A, COMT, HTR2A
12attention deficit hyperactivity disorder29.9TPH2, HTR2A, COMT
13seasonal affective disorder29.7HTR2A, CRH, TPH1, HTR1A
14eating disorder29.6HTR2A, CCK, CRH, HTR1A, CCKAR, COMT
15anxiety disorder29.5PTK7, TPH2, TPH1, TSPO, CCK, CRH
16mood disorder29.2TPH1, HTR2A, HTR1A, COMT, CRH, TPH2
17psychotic disorder29.2HTR2A, TPH2, COMT, HTR1A, CCK, TPH1
18major depressive disorder10.7
19paranoid schizophrenia10.5COMT
20alexithymia10.5
21dyspepsia10.5CCK
22separation anxiety disorder10.5
23mitral valve prolapse10.4
24blindness10.4
25neuroleptic malignant syndrome10.4HTR1A
26hypochondriasis10.4
27endogenous depression10.4CRH
28neuroendocrine tumor10.4GHRH
29specific phobia10.4
30antisocial personality disorder10.3HTR2A
31neuronitis10.3
32somatoform disorder10.3
33thyroiditis10.3
34panic disorder 310.3
35amnestic disorder10.3TSPO, HTR1A
36pancreas disease10.3CCKAR, CCK
37gastroesophageal reflux disease10.3CCK, CCKAR
38glucagonoma10.3CCK, GHRH
39autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.3TPH1, CCK
40chronic obstructive pulmonary disease10.3
41post-traumatic stress disorder10.3
42hypermobility syndrome10.3
43hypophosphatemia10.3
44seizure disorder10.3
45panic disorder 210.3
46gallbladder disease10.2CCKAR, CCK, CCKBR
47chronic fatigue syndrome10.2HTR1A, CRH
48thyroid medullary carcinoma10.2CCKAR, CCK, CCKBR
49galactosemia10.2TSPO, CCK
50asthma10.2

Graphical network of the top 20 diseases related to Panic Disorder:



Diseases related to panic disorder

Symptoms for Panic Disorder

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Symptoms by clinical synopsis from OMIM:

167870

Clinical features from OMIM:

167870

HPO human phenotypes related to Panic Disorder:

id Description Frequency HPO Source Accession
1 anxiety HP:0000739

Drugs & Therapeutics for Panic Disorder

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Genetic Tests for Panic Disorder

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Anatomical Context for Panic Disorder

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MalaCards organs/tissues related to Panic Disorder:

32
Heart, Brain, Cortex, Testes, Prefrontal cortex, Cingulate cortex, Amygdala, Pituitary, Thyroid, Eye, Lung, Breast, Skin, T cells, Hypothalamus

Animal Models for Panic Disorder or affiliated genes

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MGI Mouse Phenotypes related to Panic Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053887.9TPH2, TPH1, CCKAR, CRH, PTK7
2MP:00053797.8CCK, CCKBR, CCKAR, HTR2A, GHRH, CRH
3MP:00053857.6CCKBR, HTR1A, TPH1, TPH2, PTK7, COMT
4MP:00053787.0TPH2, PTK7, CRH, GHRH, CCKBR, TPH1
5MP:00036316.8PTK7, CRH, TPH2, CCK, CCKBR, CCKAR
6MP:00053766.5TPH2, TPH1, CCK, CCKBR, CCKAR, HTR1A
7MP:00053866.5TPH1, TPH2, CCKBR, CCKAR, HTR2A, HTR1A

Publications for Panic Disorder

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Articles related to Panic Disorder:

(show top 50)    (show all 1043)
idTitleAuthorsYear
1
GENDER-SPECIFIC ASSOCIATION OF VARIANTS IN THE AKR1C1 GENE WITH DIMENSIONAL ANXIETY IN PATIENTS WITH PANIC DISORDER: ADDITIONAL EVIDENCE FOR THE IMPORTANCE OF NEUROSTEROIDS IN ANXIETY? (24390875)
2014
2
Are TMEM genes potential candidate genes for panic disorder? (24362369)
2014
3
Azapirones versus placebo for panic disorder in adults. (25268297)
2014
4
MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy. (23319006)
2014
5
Treatment Modality Preferences and Adherence to Group Treatment for Panic Disorder with Agoraphobia. (24136085)
2013
6
A Psychometric Evaluation of the Panic Disorder Severity Scale for Children and Adolescents. (24295237)
2013
7
Structural neuroimaging in patients with panic disorder: findings and limitations of recent studies. (23793273)
2013
8
Comparison of heart rate variability in patients with panic disorder during cognitive behavioral therapy program. (23470608)
2013
9
A possible association between panic disorder and a polymorphism in the preproghrelingene. (23084284)
2013
10
Modeling panic disorder in rodents. (23584609)
2013
11
Using brain imaging to understand the response to cognitive therapy in panic disorder. (24185237)
2013
12
The effect of escitalopram on metabolic parameters in patients with major depressive disorder, generalised anxiety disorder, and panic disorder: a prospective 6-month follow-up study. (23642988)
2013
13
Neural correlates of the emotional Stroop task in panic disorder patients: an event-related fMRI study. (23058446)
2012
14
Reliability of the emotional Stroop task: an investigation of patients with panic disorder. (22770507)
2012
15
Escitalopram increased gray matter and white matter in a first-episode drug-naA^ve panic disorder patient within 6 weeks. (22772685)
2012
16
Opposing breathing therapies for panic disorder: a randomized controlled trial of lowering vs raising end-tidal P(COa88). (22901344)
2012
17
Panic-focused psychodynamic psychotherapy in a woman with panic disorder and generalized anxiety disorder. (23030215)
2012
18
Dissociation between ACTH and cortisol response in DEX-CRH test in patients with panic disorder. (22277728)
2012
19
Neuropeptide S receptor genea88--a88converging evidence for a role in panic disorder. (20603625)
2011
20
New daily persistent headache and panic disorder. (20851838)
2011
21
Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways. (21168126)
2011
22
Depersonalization and personality in panic disorder. (21683177)
2011
23
Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder. (19969287)
2010
24
Cigarette smoking and 35% CO(2) induced panic in panic disorder patients. (19896718)
2010
25
Genetics of panic disorder: focus on association studies and therapeutic perspectives. (20662753)
2010
26
No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population. (19461660)
2009
27
Panic disorder and social anxiety disorder subtypes in a caffeine challenge test. (19698996)
2009
28
Panic disorder subtypes: deceptive somatic impersonators. (19763206)
2009
29
Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val158Met genotype in patients with panic disorder during a verbal fluency task: near-infrared spectroscopy study. (19429001)
2009
30
Cognitive-behavioral treatment for panic disorder with agoraphobia: a randomized, controlled trial and cost-effectiveness analysis. (18391051)
2008
31
Alexithymia and cognitive dysfunctions in patients with panic disorder. (18332616)
2008
32
An open-label study of tiagabine in panic disorder. (18007567)
2007
33
Negative evidences in association between apolipoprotein E polymorphism and panic disorder. (15961292)
2006
34
Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study. (15930067)
2005
35
Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. (15667435)
2005
36
Lack of association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and panic disorder in humans. (15158002)
2004
37
Clinical and psychosocial outcome of patients affected by panic disorder with or without agoraphobia: results from a naturalistic follow-up study. (12547305)
2002
38
No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder. (11244486)
2001
39
Long-term treatment of panic disorder with agoraphobia in private practice. (15990481)
2000
40
Preattentive bias for emotional information in panic disorder with agoraphobia. (10369032)
1999
41
Long-term maintenance and discontinuation of imipramine therapy in panic disorder with agoraphobia. (12884888)
1999
42
Embarrassment about the first panic attack predicts agoraphobia in panic disorder patients. (9159975)
1997
43
Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). (9373423)
1997
44
Explicit and implicit memory bias in panic disorder with agoraphobia. (9431730)
1997
45
A meta-analysis of the treatment of panic disorder with or without agoraphobia: a comparison of psychopharmacological, cognitive-behavioral, and combination treatments. (9284865)
1997
46
Association of levels of N-acetyl-beta-glucosaminidase with severity of psychiatric symptoms in panic disorder. (8723309)
1996
47
On the significance of cholecystokinin receptors in panic disorder. (7863014)
1994
48
CSF cholecystokinin concentrations in patients with panic disorder and in normal comparison subjects. (1575262)
1992
49
5-HT1A receptor-effector system responsivity in panic disorder. (1346719)
1992
50
Thyroid hormones in panic disorder, panic disorder with agoraphobia, and generalized anxiety disorder. (3379028)
1988

Variations for Panic Disorder

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Expression for genes affiliated with Panic Disorder

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Expression patterns in normal tissues for genes affiliated with Panic Disorder

Search GEO for disease gene expression data for Panic Disorder.

Pathways for genes affiliated with Panic Disorder

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Pathways related to Panic Disorder according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
catecholamine biosynthesis37
9.7COMT, TPH1
2
Show member pathways
9.5HTR1A, HTR2A
3
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)37
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA37
tryptophan degradation37
glutaryl-CoA degradation37
serotonin degradation37
NAD de novo biosynthesis37
superpathway of melatonin degradation37
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde37
tryptophan utilization I37
melatonin degradation I37
9.1TPH1, TPH2
4
Show member pathways
serotonin and melatonin biosynthesis37
9.1TPH1, TPH2
59.1CCKBR, CCKAR, HTR2A
6
Show member pathways
8.8CCK, CCKBR, CCKAR, HTR2A
7
Show member pathways
8.7PTK7, HTR2A, HTR1A, GHRH
88.1HTR1A, HTR2A, TPH1, TPH2
98.1HTR1A, HTR2A, TPH1, TPH2
10
Show member pathways
7.9TPH2, TPH1, HTR2A, HTR1A, COMT
11
Show member pathways
7.5CCK, CCKBR, CCKAR, HTR2A, HTR1A, GHRH
12
Show member pathways
7.1CRH, TSPO, CCK, CCKBR, CCKAR, HTR2A

Compounds for genes affiliated with Panic Disorder

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Compounds related to Panic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 223)
idCompoundScoreTop Affiliating Genes
1cholecystokinin tetrapeptide449.9CCKBR, CCK, PTK7
2asperlicin449.9CCKAR, CCK, PTK7
31,4-benzodiazepine449.8CCKAR, CCK, TSPO
4lorglumide44 2810.8CCKBR, CCK, CCKAR
5l365260449.8CCKAR, CCKBR, CCK
6ym022449.8CCK, CCKBR, CCKAR
7devazepide44 61 2811.7CCKAR, CCKBR, CCK
8loxiglumide449.7CCKAR, CCKBR, CCK
9benzodiazepines449.5TSPO, CCKAR, CCK, CCKBR
10tetrapeptide449.4CCKAR, CCKBR, PTK7, CCK
11inositol triphosphate449.3CCKBR, CRH, CCK
12raclopride44 2810.3HTR2A, CCK, HTR1A, CCKBR
13buspirone44 28 1111.2TSPO, HTR2A, HTR1A
14morphine44 50 28 1112.2CCKBR, CCKAR, COMT, CCK, TSPO
15ondansetron50 44 24 1112.1HTR1A, HTR2A, CCK, CCKAR
16naloxone44 28 50 1112.1TSPO, GHRH, CCK, CRH
17methysergide44 28 1111.1CCK, HTR1A, HTR2A
18tetrodotoxin44 61 2811.1CCKAR, CRH, CCKBR, CCK
19bromocriptine44 28 1111.0HTR2A, HTR1A, GHRH, COMT
20clomipramine44 50 1111.0HTR1A, HTR2A, TSPO, CRH
21paroxetine44 50 28 1112.0HTR2A, COMT, HTR1A, TPH1
22amide449.0GHRH, CCK, CCKBR, CCKAR
23atropine44 28 1111.0CCKAR, CRH, GHRH, CCK
24opiate449.0GHRH, CCK, TSPO, CRH
25yohimbine44 2 28 1112.0HTR1A, HTR2A, CRH, CCKBR
26ropinirole44 119.9HTR2A, HTR1A, COMT
27levodopa44 119.9TPH1, TSPO, HTR1A, GHRH, COMT
28octreotide44 61 28 1111.9CRH, GHRH, CCKAR, CCKBR, CCK
29haloperidol44 50 28 2 1112.8HTR1A, HTR2A, CCKAR, TSPO, CCKBR
30venlafaxine44 50 24 1111.8TPH2, HTR2A, HTR1A, COMT
31nicotine44 28 50 1111.8COMT, CCKBR, TSPO, TPH1, CRH
32fluvoxamine44 50 1110.8TPH1, TSPO, HTR1A, COMT, HTR2A
33l-tryptophan50 28 44 24 1112.8TPH1, TPH2, TSPO, HTR1A
34benzodiazepine448.7PTK7, CCK, CCKBR, CCKAR, CRH, TSPO
35cocaine44 119.7CRH, COMT, CCKBR, CCK, CCKAR, TSPO
36propranolol44 28 50 24 1112.7HTR1A, PTK7, GHRH, COMT, CRH, TSPO
37acth448.6HTR1A, CRH, GHRH, CCKBR, PTK7, CCK
385-hydroxytryptophan448.6CRH, PTK7, HTR2A, HTR1A, TPH1
39citalopram44 50 24 1111.6CRH, HTR2A, HTR1A, PTK7, TPH1
40antidepressants508.5HTR1A, HTR2A, TPH1, TPH2
41gaba448.5CCKAR, CRH, PTK7, TPH1, TSPO, CCK
42acetylcholine44 50 28 24 1112.4CRH, HTR1A, CCKBR, TSPO, CCK, TPH1
43maoa448.3TPH1, TPH2, HTR2A, COMT, HTR1A
44phenylalanine448.3TPH1, CCK, CCKBR, CCKAR, TPH2
45fluoxetine44 50 28 1111.0CRH, TPH1, TPH2, HTR2A, HTR1A
46glutamate448.0TPH1, COMT, GHRH, CCKBR, CCK, TSPO
47fenfluramine44 28 119.3HTR1A, GHRH, CRH, CCK, TPH1, TPH2
48norepinephrine44 24 119.2CCK, HTR2A, HTR1A, GHRH, COMT, CRH
495-hydroxytryptamine447.1TPH2, TPH1, TSPO, CCK, HTR2A, HTR1A
50dopamine44 28 24 119.5CRH, COMT, GHRH, HTR1A, HTR2A, CCKAR

GO Terms for genes affiliated with Panic Disorder

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Cellular components related to Panic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1terminal boutonGO:0431959.7GHRH, CCK
2integral component of plasma membraneGO:0058878.2HTR1A, HTR2A, CCKAR, CCKBR, PTK7

Biological processes related to Panic Disorder according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1cholecystokinin signaling pathwayGO:03818810.1CCKBR, CCKAR
2positive regulation of mitochondrial depolarizationGO:05190110.1CCK, TSPO
3regulation of serotonin secretionGO:0140629.9HTR1A, CRH
4behavioral fear responseGO:0016629.8HTR1A, CCK
5response to painGO:0482659.8COMT, CRH
6regulation of hormone secretionGO:0468839.8HTR2A, HTR1A
7response to immobilization stressGO:0359029.7CRH, TPH1
8adrenal gland developmentGO:0303259.7CRH, TSPO
9serotonin receptor signaling pathwayGO:0072109.7HTR1A, HTR2A
10regulation of behaviorGO:0507959.6HTR1A, HTR2A
11feeding behaviorGO:0076319.6CRH, CCKAR, CCKBR
12phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.4CCKAR, CCKBR
13serotonin biosynthetic processGO:0424279.4TPH2, TPH1
14aromatic amino acid family metabolic processGO:0090729.4TPH2, TPH1
15positive regulation of cAMP biosynthetic processGO:0308199.4GHRH, CRH
16indolalkylamine biosynthetic processGO:0462199.4TPH1, TPH2
17circadian rhythmGO:0076239.1TPH1, TPH2
18response to drugGO:0424939.0TSPO, HTR2A, COMT, CRH
19synaptic transmissionGO:0072688.9TSPO, HTR2A, COMT, CRH
20positive regulation of cell proliferationGO:0082848.2CRH, CCK, CCKBR, HTR2A, HTR1A, GHRH

Molecular functions related to Panic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholecystokinin receptor activityGO:0049519.7CCKAR, CCKBR
2neuropeptide hormone activityGO:0051849.7CRH, CCK
3serotonin receptor activityGO:0049939.4HTR2A, HTR1A
4tryptophan 5-monooxygenase activityGO:0045109.2TPH1, TPH2
5amino acid bindingGO:0165978.8TPH1, TPH2

Products for genes affiliated with Panic Disorder

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Sources for Panic Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet