PANIC
MCID: PNC025
MIFTS: 62

Panic Disorder (PANIC) malady

Neuronal category

Summaries for Panic Disorder

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Panic disorder is a type of anxiety disorder. it causes panic attacks, which are sudden feelings of terror when there is no real danger. you may feel as if you are losing control. you may also have physical symptoms, such as fast heartbeat chest or stomach pain breathing difficulty weakness or dizziness sweating feeling hot or a cold chill tingly or numb hands panic attacks can happen anytime, anywhere, and without warning. you may live in fear of another attack and may avoid places where you have had an attack. for some people, fear takes over their lives and they cannot leave their homes. panic disorder is more common in women than men. it usually starts when people are young adults. sometimes it starts when a person is under a lot of stress. most people get better with treatment. therapy can show you how to recognize and change your thinking patterns before they lead to panic. medicines can also help. nih: national institute of mental health

MalaCards: Panic Disorder, also known as panic anxiety syndrome, is related to agoraphobia and anxiety disorder. An important gene associated with Panic Disorder is COMT (catechol-O-methyltransferase), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The compounds dopamine and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and lung, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.

Wikipedia:64 Panic disorder is an anxiety disorder characterized by recurring severe panic attacks. It may also... more...

Description from OMIM:47 167870

Aliases & Classifications for Panic Disorder

Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

panic disorder 8 47 10 45 34
panic anxiety syndrome 8
panic disorder 1 61
panic 45


External Ids:

Disease Ontology8 DOID:594
MeSH35 D016584
NCIt40 C34890
ICD1025 F41.0

Related Diseases for Panic Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Panic Disorder family:

panic disorder 3 panic disorder 2
panic disorder syndrome 1

Diseases related to Panic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1agoraphobia31.9PTK7, CCKBR, MAOA, HTR1A, SLC6A2
2anxiety disorder31.4TPH2, TPH1, SLC6A4, MAOA, CRH
3generalized anxiety disorder31.1SLC6A4, HTR1A, TSPO
4social phobia31.0COMT, SLC6A4, MAOA, HTR1A
5obsessive-compulsive disorder30.9TPH1, TSPO, SLC6A2, SLC6A4, MAOA, HTR2A
6bipolar disorder30.7HTR2A, SLC6A4
7irritable bowel syndrome30.5CRH, CCK, SLC6A4, TPH1
8conduct disorder30.2COMT, SLC6A4, MAOA
9substance dependence30.2COMT, TPH1, SLC6A4
10alcohol abuse30.2SLC6A4, COMT
11dysthymic disorder30.2HTR2A, MAOA
12asthma30.2ADORA2A, TSPO, HTR2A
13attention deficit hyperactivity disorder30.0SLC6A2, COMT, SLC6A4, TPH2, HTR2A, MAOA
14seasonal affective disorder30.0HTR1A, SLC6A4, HTR2A, TPH1, CRH
15alcohol dependence30.0SLC6A4, CRH, HTR2A, MAOA
16borderline personality disorder30.0TPH1, SLC6A4, MAOA
17substance abuse30.0SLC6A4, CRH
18hyperprolactinemia30.0CRH, GHRH, TRH
19nicotine dependence30.0SLC6A4
20premature ejaculation30.0HTR1A, SLC6A4
21major depressive disorder10.7
22separation anxiety disorder10.6
23alexithymia10.5
24mitral valve prolapse10.4
25hypochondriasis10.4
26pain disorder10.4
27somatoform disorder10.4
28specific phobia10.4
29panic disorder 210.4
30sleep disorder10.4
31withdrawal disorder10.4
32panic disorder 310.3
33hypophosphatemia10.2
34post-traumatic stress disorder10.2
35hypermobility syndrome10.2
36seizure disorder10.2
37pulmonary disease, chronic obstructive10.2
38insomnia10.2
39coronary artery disease,10.2
40panic disorder syndrome 110.2
41obsessive-compulsive personality disorder10.1
42acute stress disorder10.1
43avoidant personality disorder10.0
44histrionic personality disorder10.0
45multiple chemical sensitivity10.0
46depersonalization disorder10.0
47somatization disorder10.0
48dependent personality disorder10.0
49retinitis pigmentosa10.0
50hyperhomocysteinemia10.0

Graphical network of the top 20 diseases related to Panic Disorder:



Diseases related to panic disorder

Clinical Features for Panic Disorder

Sources:
47OMIM
See all sources

Clinical features from OMIM:

167870

Clinical synopsis from OMIM:

167870

Drugs & Therapeutics for Panic Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Panic Disorder

Drug clinical trials:

Search ClinicalTrials for Panic Disorder

Search NIH Clinical Center for Panic Disorder

Search CenterWatch for Panic Disorder

Genetic Tests for Panic Disorder

Anatomical Context for Panic Disorder

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Panic Disorder:

33
Skin, Brain, Lung, Cortex, Heart, Thyroid, Breast, T cells, B cells, Prefrontal cortex, Cingulate cortex, Parietal lobe, Temporal lobe, Occipital lobe, Hypothalamus, Amygdala, Adrenal cortex, Pituitary

Animal Models for Panic Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Panic Disorder

Sources:
51PubMed
See all sources

Articles related to Panic Disorder:

(show top 50)    (show all 1059)
idTitleAuthorsYear
1
GENDER-SPECIFIC ASSOCIATION OF VARIANTS IN THE AKR1C1 GENE WITH DIMENSIONAL ANXIETY IN PATIENTS WITH PANIC DISORDER: ADDITIONAL EVIDENCE FOR THE IMPORTANCE OF NEUROSTEROIDS IN ANXIETY? (24390875)
2014
2
Reduced anterior temporal and hippocampal functional connectivity during face processing discriminates individuals with social anxiety disorder from healthy controls and panic disorder, and increases following treatment. (24084831)
2014
3
Health-seeking behavior, alternative medicine, and quality of life in Taiwanese panic disorder patients. (22809126)
2013
4
The separation anxiety hypothesis of panic disorder revisited: a meta-analysis. (23680783)
2013
5
Decreased cardiac vagal control in drug-naive patients with panic disorder: a case-control study in Taiwan. (23857808)
2013
6
Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model. (24048855)
2013
7
Cost-effectiveness of CBT, SSRI, and CBT+SSRI in the treatment for panic disorder. (23834587)
2013
8
Panic disorder in children and adolescents with noncardiac chest pain. (23378228)
2013
9
Effect of cognitive-behavioral therapy on neural correlates of fear conditioning in panic disorder. (22921454)
2013
10
The effects of maternal major depression, generalized anxiety disorder, and panic disorder on birth weight and gestational age: a comparative study. (23751245)
2013
11
Altered cortical gyrification patterns in panic disorder: deficits and potential compensation. (23871448)
2013
12
Specificity of homework compliance effects on treatment outcome in CBT: evidence from a controlled trial on panic disorder and agoraphobia. (23504641)
2013
13
Recognition of facial expressions of emotion in panic disorder. (22797533)
2012
14
Avoidant coping in panic disorder: a yohimbine biological challenge study. (21864204)
2012
15
Panic disorder and school refusal. (22800996)
2012
16
The role of "interoceptive" fear conditioning in the development of panic disorder. (22304891)
2012
17
Re-examining the differential familial liability of agoraphobia and panic disorder. (22786750)
2012
18
Coping skills and exposure therapy in panic disorder and agoraphobia: latest advances and future directions. (22440065)
2012
19
Gender differences in brain serotonin transporter availability in panic disorder. (21148024)
2011
20
Depressive disorders and panic attacks in women with bladder pain syndrome/interstitial cystitis: a population-based sample. (21596207)
2011
21
Panic disorder, autonomic nervous system and dissociation - changes during therapy. (22167145)
2011
22
A new paradigm (Westphal-Paradigm) to study the neural correlates of panic disorder with agoraphobia. (21113608)
2011
23
Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder. (19969287)
2010
24
Association between the catechol-O-methyltransferase Val158Met polymorphism and panic disorder: a replication. (20457471)
2010
25
Two cases of panic disorder responsive to low-dose sertraline. (20661029)
2010
26
Internet-versus group-administered cognitive behaviour therapy for panic disorder in a psychiatric setting: a randomised trial. (20598127)
2010
27
Adjunctive valproate in panic disorder patients with comorbid bipolar disorder or otherwise resistant to standard antidepressants: a 3-year "open" follow-up study. (20238120)
2010
28
Mechanism of action in CBT (MAC): methods of a multi-center randomized controlled trial in 369 patients with panic disorder and agoraphobia. (19876674)
2009
29
Negative evidences in association between apolipoprotein E polymorphism and panic disorder. (15961292)
2006
30
Differential response to placebo among patients with social phobia, panic disorder, and obsessive-compulsive disorder. (15285978)
2004
31
Anxiety with panic disorder linked to chromosome 9q in Iceland. (12679899)
2003
32
Styles of adaptation in panic disorder with and without agoraphobia. (15002868)
2003
33
Is the autonomic dysfunction the missing link between panic disorder, hypertension and cardiovascular disease? (12473854)
2002
34
Exonic variants of the GABA(B) receptor gene and panic disorder. (11324945)
2000
35
Increased psychological responses and divergent neuroendocrine responses to m-CPP and ipsapirone in patients with panic disorder. (10870873)
2000
36
Mitral valve prolapse versus panic disorder in patients with chest pain. (10847792)
2000
37
Selective serotonin reuptake inhibitors in the treatment of panic disorder and agoraphobia. (11110016)
2000
38
Long-term maintenance and discontinuation of imipramine therapy in panic disorder with agoraphobia. (12884888)
1999
39
Does preference for type of treatment matter? A study of exposure in vivo with or without hypnosis in the treatment of panic disorder with agoraphobia. (9086865)
1997
40
Interoceptive exposure versus breathing retraining within cognitive-behavioural therapy for panic disorder with agoraphobia. (9051281)
1997
41
Age at onset of panic disorder: influence of familial liability to the disease and of childhood separation anxiety disorder. (7653694)
1995
42
A controlled study of cognitive behaviour therapy with buspirone or placebo in panic disorder with agoraphobia. (8564320)
1995
43
Comment on the London/Toronto Study of Alprazolam and Exposure in Panic Disorder with Agoraphobia. (8101127)
1993
44
Panic disorder with agoraphobia. (7905776)
1993
45
Alprazolam plasma concentrations and treatment response in panic disorder and agoraphobia. (1415824)
1992
46
Avoidant and dependent personality traits in relatives of patients with panic disorder, patients with dependent personality disorder, and normal controls. (1771212)
1991
47
Serotonin function in panic disorder: a double blind placebo controlled study with fluvoxamine and ritanserin. (1697419)
1990
48
Etizolam versus placebo in the treatment of panic disorder with agoraphobia: a double-blind study. (2272192)
1990
49
Social-evaluative anxiety in panic disorder and agoraphobia. (3363071)
1988
50
Panic disorder and agoraphobia. (3432428)
1987

Genetic Variations for Panic Disorder

Expression for genes affiliated with Panic Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Panic Disorder

Search GEO for disease gene expression data for Panic Disorder.

Pathways for genes affiliated with Panic Disorder

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 50PharmGKB
See all sources

Pathways related to Panic Disorder according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7ADORA2A, CCKAR, CCKBR, CCK, HTR1A, HTR2A
2
Hide members
10.7CCKAR, CCKBR, CCK, HTR1A, HTR2A, CRH
310.6HTR1A, HTR2A, MAOA, SLC6A4, TPH1, TPH2
4
Hide members
10.6COMT, HTR1A, HTR2A, MAOA, SLC6A4
5
Hide members
10.6CCKAR, CCKBR, CCK, HTR2A, TRH
610.6CCKAR, CCKBR, HTR2A, ADORA2A
7
Hide members
10.6SLC6A4, MAOA, HTR2A, HTR1A
810.6SLC6A4, SLC6A2, ADORA2A, TPH2
910.5ADORA2A, HTR2A, CCKBR
10
Hide members
10.5MAOA, TPH1, TPH2
11
Hide members
10.5TPH2, TPH1, MAOA
12
Hide members
10.5MAOA, COMT
13
Hide members
10.5SLC6A2, SLC6A4
14
Hide members
10.5TPH2, TPH1
15
Hide members
10.5TPH1, TPH2
16
Hide members
10.5TPH2, TPH1

Compounds for genes affiliated with Panic Disorder

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Panic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 267)
idCompoundScoreTop Affiliating Genes
1dopamine45 29 11 2414.3COMT, TPH1, CCKAR, CCKBR, CCK, ADORA2A
2norepinephrine45 11 2413.2GHRH, CRH, HTR2A, HTR1A, CCK, COMT
35-hydroxytryptamine4511.2TSPO, SLC6A2, SLC6A4, MAOA, CRH, HTR2A
4gaba4511.2TPH1, ADORA2A, TSPO, PTK7, SLC6A2, SLC6A4
5cocaine45 1112.1TRH, CRH, CCK, CCKBR, CCKAR, COMT
6glutamate4511.1COMT, CCKBR, CCK, CRH, TRH, MAOA
7haloperidol45 29 2 50 1115.1CCKAR, CCKBR, HTR1A, HTR2A, SLC6A4, SLC6A2
8benzodiazepine4511.1TSPO, PTK7, MAOA, CCK, CCKBR, CCKAR
9fenfluramine29 45 1113.1CCK, HTR1A, HTR2A, CRH, GHRH, TPH2
10fluoxetine50 45 29 1114.1TPH2, TPH1, SLC6A2, HTR1A, HTR2A, CRH
11maoa4511.1COMT, SLC6A2, TPH2, TPH1, SLC6A4, MAOA
12citalopram50 45 11 2414.1TPH1, PTK7, SLC6A2, SLC6A4, MAOA, HTR2A
13levodopa45 1112.1TSPO, TPH1, ADORA2A, COMT, MAOA, TRH
14clomipramine45 50 1113.1TSPO, SLC6A2, SLC6A4, MAOA, CRH, HTR1A
15acetylcholine45 50 29 11 2415.1CCK, CRH, TRH, CCKBR, TPH1, ADORA2A
16fluvoxamine45 50 1113.1HTR1A, HTR2A, SLC6A4, SLC6A2, TSPO, TPH1
17nicotine45 50 29 1114.1MAOA, CRH, SLC6A4, SLC6A2, TPH1, CCKBR
18paroxetine45 50 29 1114.0SLC6A2, COMT, HTR1A, HTR2A, MAOA, SLC6A4
19desipramine45 50 1113.0MAOA, TRH, SLC6A2, CRH, HTR2A, SLC6A4
205-hydroxytryptophan4511.0PTK7, TPH1, CRH, SLC6A4, HTR2A, HTR1A
21homovanillic acid45 2412.0SLC6A2, SLC6A4, CRH, COMT, MAOA, TPH1
22amine4511.0ADORA2A, TRH, SLC6A4, COMT, MAOA, SLC6A2
23benzodiazepines4511.0TSPO, CCKAR, CCKBR, CCK, MAOA
24amphetamine45 1112.0CCKBR, CCK, SLC6A4, SLC6A2, TPH1, MAOA
25mptp4511.0ADORA2A, SLC6A2, MAOA, COMT, SLC6A4, TSPO
26mdma4511.0MAOA, SLC6A4, HTR1A, SLC6A2, TPH1
27mhpg4511.0COMT, MAOA, SLC6A4, SLC6A2, CRH
28octreotide45 60 29 1114.0CCKBR, CCKAR, CCK, CRH, GHRH, TRH
29mianserin29 45 1112.9HTR2A, HTR1A, MAOA, SLC6A4, SLC6A2
30sertraline45 29 50 11 2414.9HTR1A, CRH, SLC6A2, SLC6A4, MAOA
31opiate4510.9ADORA2A, CRH, CCK, SLC6A4, TSPO, GHRH
32venlafaxine50 45 11 2413.9SLC6A2, SLC6A4, HTR1A, HTR2A, TPH2
33propranolol45 29 50 11 2414.9COMT, HTR1A, CRH, PTK7, TSPO, GHRH
34acth4510.9CCKBR, CCK, HTR1A, CRH, GHRH, TRH
355-hydroxyindoleacetic acid45 2411.9SLC6A2, TPH1, MAOA, CRH, SLC6A4
36carbon-114510.9SLC6A4, MAOA, HTR1A, TSPO
37p-chloroamphetamine4510.9SLC6A4, SLC6A2, MAOA, HTR1A
38morphine45 50 29 1113.8COMT, CCK, TRH, CCKAR, CCKBR, TSPO
39MMDA1110.8SLC6A2, SLC6A4, MAOA, HTR2A
40estrogen4510.8TSPO, TPH1, TPH2, SLC6A2, SLC6A4, MAOA
41spec-t4510.8CRH, SLC6A4, TSPO, ADORA2A, SLC6A2
42d amphetamine4510.8SLC6A4, SLC6A2, TSPO, MAOA
43raclopride45 2911.8CCKBR, CCK, HTR1A, HTR2A
44amitriptyline45 50 29 1113.8SLC6A4, MAOA, SLC6A2, HTR2A, HTR1A
45bromocriptine29 45 1112.7HTR1A, COMT, HTR2A, GHRH, TRH
46naloxone45 50 29 1113.7CCK, TRH, TSPO, CRH, GHRH
47nmda45 2911.6CCKBR, COMT, MAOA, TSPO, ADORA2A, HTR1A
48escitalopram45 50 11 2413.6HTR2A, SLC6A2, HTR1A, SLC6A4
49methamphetamine45 50 1112.5SLC6A4, MAOA, TPH1, SLC6A2, COMT
50antidepressants5010.3HTR1A, HTR2A, TPH1, TPH2

GO Terms for genes affiliated with Panic Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Panic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.7ADORA2A, PTK7, SLC6A2, SLC6A4, HTR2A, HTR1A

Biological processes related to Panic Disorder according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1response to drugGO:04249311.0ADORA2A, TSPO, SLC6A4, CRH, HTR2A, COMT
2positive regulation of cell proliferationGO:00828411.0GHRH, CRH, HTR2A, HTR1A, CCK, CCKBR
3response to painGO:04826510.9COMT, CRH, SLC6A2
4eating behaviorGO:04275510.9CCK, TRH, ADORA2A
5feeding behaviorGO:00763110.9CCKAR, CCKBR, CRH
6regulation of serotonin secretionGO:01406210.9CRH, HTR1A
7cholecystokinin signaling pathwayGO:03818810.9CCKBR, CCKAR
8regulation of hormone secretionGO:04688310.8HTR1A, HTR2A
9synaptic transmissionGO:00726810.8COMT, HTR2A, CRH, MAOA, SLC6A2
10serotonin biosynthetic processGO:04242710.8TPH1, TPH2
11dopamine catabolic processGO:04242010.8COMT, MAOA
12aromatic amino acid family metabolic processGO:00907210.8TPH1, TPH2
13circadian rhythmGO:00762310.8TPH2, TPH1, SLC6A4
14response to immobilization stressGO:03590210.8CRH, TPH1
15indolalkylamine biosynthetic processGO:04621910.7TPH2, TPH1
16positive regulation of mitochondrial depolarizationGO:05190110.7CCK, TSPO
17monoamine transportGO:01584410.7SLC6A4, SLC6A2
18neurotransmitter catabolic processGO:04213510.7MAOA, COMT
19sensory perceptionGO:00760010.6CCKBR, ADORA2A
20serotonin receptor signaling pathwayGO:00721010.6HTR1A, HTR2A
21regulation of behaviorGO:05079510.5HTR1A, HTR2A
22vasoconstrictionGO:04231010.5SLC6A4, HTR1A
23synaptic transmission, dopaminergicGO:00196310.4CRH, ADORA2A
24neurotransmitter biosynthetic processGO:04213610.2MAOA, COMT

Molecular functions related to Panic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00518410.5TRH, CRH, CCK
2monoamine transmembrane transporter activityGO:00850410.5SLC6A2, SLC6A4
3tryptophan 5-monooxygenase activityGO:00451010.4TPH2, TPH1
4cholecystokinin receptor activityGO:00495110.2CCKBR, CCKAR

Products for genes affiliated with Panic Disorder

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  • Proteins
  • Lysates
  • Antibodies

Sources for Panic Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet