PANIC
MCID: PNC025
MIFTS: 65

Panic Disorder (PANIC) malady

Neuronal diseases category

Summaries for Panic Disorder

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Panic disorder is a type of anxiety disorder. it causes panic attacks, which are sudden feelings of terror when there is no real danger. you may feel as if you are losing control. you may also have physical symptoms, such as fast heartbeat chest or stomach pain breathing difficulty weakness or dizziness sweating feeling hot or a cold chill tingly or numb hands panic attacks can happen anytime, anywhere, and without warning. you may live in fear of another attack and may avoid places where you have had an attack. for some people, fear takes over their lives and they cannot leave their homes. panic disorder is more common in women than men. it usually starts when people are young adults. sometimes it starts when a person is under a lot of stress. most people get better with treatment. therapy can show you how to recognize and change your thinking patterns before they lead to panic. medicines can also help. nih: national institute of mental health

MalaCards: Panic Disorder, also known as panic anxiety syndrome, is related to agoraphobia and anxiety disorder. An important gene associated with Panic Disorder is COMT (catechol-O-methyltransferase), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The compounds dopamine and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and cortex, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.

Wikipedia:63 Panic disorder is an anxiety disorder characterized by recurring severe panic attacks. It may also... more...

Description from OMIM:46 167870

Aliases & Classifications for Panic Disorder

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

panic disorder 8 46 10 44 33
panic anxiety syndrome 8
panic disorder 1 60
panic 44


External Ids:

Disease Ontology8 DOID:594
MeSH34 D016584
NCIt39 C34890
ICD1025 F41.0

Related Diseases for Panic Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Panic Disorder family:

Panic Disorder 3 Panic Disorder 2
Panic Disorder Syndrome 1

Diseases related to Panic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1agoraphobia31.8CCKBR, HTR1A, MAOA, SLC6A2, PTK7
2anxiety disorder31.4CRH, MAOA, SLC6A4, TPH1, TPH2
3generalized anxiety disorder31.0TSPO, SLC6A4, HTR1A
4personality disorder31.0MAOA, SLC6A4, TPH1, TPH2
5social phobia31.0COMT, HTR1A, MAOA, SLC6A4
6obsessive-compulsive disorder30.9SLC6A2, TSPO, TPH1, TPH2, SLC6A4, MAOA
7bipolar disorder30.6HTR2A, SLC6A4
8schizophrenia30.6HTR2A, COMT
9irritable bowel syndrome30.5CCK, CRH, SLC6A4, TPH1
10thyroiditis30.4TRH
11mood disorder30.3SLC6A4, SLC6A2, TPH1, TPH2, MAOA, TRH
12migraine30.3COMT, HTR1A, HTR2A, MAOA, SLC6A4, TPH1
13eating disorder30.2SLC6A4, COMT, CCKAR, CCK, HTR1A, HTR2A
14conduct disorder30.2SLC6A4, MAOA, COMT
15substance dependence30.2COMT, SLC6A4, TPH1
16hypertension30.2SLC6A4, CRH
17alcohol abuse30.2COMT, SLC6A4
18dysthymic disorder30.2HTR2A, MAOA
19asthma30.2HTR2A, TSPO, ADORA2A
20psychotic disorder29.9CCK, HTR1A, HTR2A, MAOA, SLC6A4, TPH1
21attention deficit hyperactivity disorder29.9COMT, HTR2A, MAOA, SLC6A4, SLC6A2, TPH2
22seasonal affective disorder29.9HTR1A, HTR2A, CRH, SLC6A4, TPH1
23alcohol dependence29.9HTR2A, CRH, MAOA, SLC6A4
24borderline personality disorder29.9MAOA, SLC6A4, TPH1
25substance abuse29.9CRH, SLC6A4
26essential hypertension29.9COMT, HTR2A, SLC6A2, ADORA2A
27hyperprolactinemia29.9TRH, GHRH, CRH
28nicotine dependence29.9SLC6A4
29breast cancer29.9GHRH, COMT
30premature ejaculation29.9SLC6A4, HTR1A
31major depressive disorder10.8
32separation anxiety disorder10.5
33alexithymia10.4
34physical disorder10.4
35mitral valve prolapse10.4
36hypochondriasis10.4
37pain disorder10.4
38dissociative disorder10.4
39somatoform disorder10.4
40specific phobia10.4
41sleep disorder10.3
42withdrawal disorder10.3
43neuronitis10.3
44hypophosphatemia10.2
45somatization disorder10.2
46post-traumatic stress disorder10.2
47hypermobility syndrome10.2
48panic disorder 310.2
49panic disorder 210.2
50coronary artery disease10.1

Graphical network of the top 20 diseases related to Panic Disorder:



Diseases related to panic disorder

Clinical Features for Panic Disorder

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Sources:
46OMIM
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Clinical features from OMIM:

167870

Clinical synopsis from OMIM:

167870

Drugs & Therapeutics for Panic Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Panic Disorder

Drug clinical trials:

Search ClinicalTrials for Panic Disorder

Search NIH Clinical Center for Panic Disorder

Search CenterWatch for Panic Disorder

Genetic Tests for Panic Disorder

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Anatomical Context for Panic Disorder

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Sources:
32MalaCards
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MalaCards organs/tissues related to Panic Disorder:

32
Heart, Brain, Cortex, Testes, Prefrontal cortex, Amygdala, Pituitary, Cingulate cortex, Thyroid, T cells, Lung, Hypothalamus, Eye, Skin, Breast

Animal Models for Panic Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Panic Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.9TPH2, COMT, CCKAR, CCKBR, CCK, HTR1A
2MP:000538610.9HTR2A, HTR1A, CCKBR, CCKAR, COMT, CRH
3MP:000537610.9CRH, HTR1A, CCK, CCKBR, CCKAR, COMT
4MP:000537810.7CCKAR, CCKBR, CRH, GHRH, TRH, SLC6A4
5MP:001077110.6CRH, SLC6A4, SLC6A2, ADORA2A, TPH1, TPH2
6MP:000537910.6CCKAR, CCKBR, CCK, HTR2A, CRH, GHRH
7MP:000538510.4COMT, CCKBR, HTR1A, MAOA, SLC6A4, PTK7

Publications for Panic Disorder

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Sources:
50PubMed
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Articles related to Panic Disorder:

(show top 50)    (show all 1057)
idTitleAuthorsYear
1
Panic disorder among African Americans, Caribbean blacks and non-Hispanic whites. (22983664)
2013
2
Epigenetic signature of panic disorder: a role of glutamate decarboxylase 1 (GAD1) DNA hypomethylation? (23906988)
2013
3
Perievent panic attacks and panic disorder after mass trauma: a 12-month longitudinal study. (23696332)
2013
4
A randomized, double-blind, placebo-controlled study of ziprasidone monotherapy in bipolar disorder with co-occurring lifetime panic or generalized anxiety disorder. (24345758)
2013
5
Gabapentin in somatoform and panic disorder. (23288241)
2013
6
Evaluation of the effects of venlafaxine and pregabalin on the carbon dioxide inhalation models of Generalised Anxiety Disorder and panic. (22516666)
2013
7
Baseline respiratory parameters in panic disorder: a meta-analysis. (23107756)
2013
8
Reliability of the emotional Stroop task: an investigation of patients with panic disorder. (22770507)
2012
9
Biological understanding of the cardiovascular risk associated with major depression and panic disorder is important. (22122655)
2012
10
The relationships among heart rate variability, executive functions, and clinical variables in patients with panic disorder. (23069273)
2012
11
The impact of an 8-day intensive treatment for adolescent panic disorder and agoraphobia on comorbid diagnoses. (22304887)
2012
12
Serum ghrelin levels and the effects of antidepressants in major depressive disorder and panic disorder. (22948519)
2012
13
Amygdala responses to masked and low spatial frequency fearful faces: a preliminary fMRI study in panic disorder. (22944369)
2012
14
Interoceptive fear conditioning and panic disorder: the role of conditioned stimulus-unconditioned stimulus predictability. (22304889)
2012
15
Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder. (22099954)
2012
16
Emerging drugs for panic disorder. (21999303)
2011
17
Altered auditory processing in patients with panic disorder: a pilot study. (20586534)
2010
18
Cerebral autoregulation in panic disorder. (20627319)
2010
19
Respiratory, autonomic, and experiential responses to repeated inhalations of 20% COa88 enriched air in panic disorder, social phobia, and healthy controls. (20064582)
2010
20
Improved statistical analysis of moclobemide dose effects on panic disorder treatment. (19936819)
2010
21
Slow vs standard up-titration of paroxetine in the treatment of panic disorder: a prospective randomized trial. (21040188)
2010
22
A randomized controlled study of paroxetine and cognitive-behavioural therapy for late-life panic disorder. (19958308)
2010
23
Respiratory and cognitive mediators of treatment change in panic disorder: evidence for intervention specificity. (20873904)
2010
24
Changes in central sodium and not osmolarity or lactate induce panic-like responses in a model of panic disorder. (20130534)
2010
25
Aripiprazole-related subcortical growth in a patient with major depressive disorder and panic disorder. (20631573)
2010
26
Effect of gender on processing threat-related stimuli in patients with panic disorder: sex does matter. (20602432)
2010
27
Association analysis of Rgs7 variants with panic disorder. (18762858)
2009
28
Is a combined therapy more effective than either CBT or SSRI alone? Results of a multicenter trial on panic disorder with or without agoraphobia. (18307586)
2008
29
Treatment of panic disorder with agoraphobia: randomized placebo-controlled trial of four psychosocial treatments combined with imipramine or placebo. (18608313)
2008
30
Levels of adenosine deaminase and dipeptidyl peptidase IV in patients with panic disorder]. (18561047)
2008
31
Does the association between mitral valve prolapse and panic disorder really exist? (18311420)
2008
32
Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gender specificity. (17357147)
2007
33
HPA axis activity in patients with panic disorder: review and synthesis of four studies. (16845643)
2007
34
Therapists' emotional reactions to patients as a mediator in cognitive behavioural treatment of panic disorder with agoraphobia. (16952901)
2006
35
Selective GABAergic treatment for panic? Investigations in experimental panic induction and panic disorder. (15944741)
2005
36
A meta-analysis of the efficacy of psycho- and pharmacotherapy in panic disorder with and without agoraphobia. (16005982)
2005
37
Association study of 90 candidate gene polymorphisms in panic disorder. (15722953)
2005
38
The effect of fear on paralinguistic aspects of speech in patients with panic disorder with agoraphobia. (15749571)
2005
39
Perceived criticism predicts severity of anxiety symptoms after behavioral treatment in patients with obsessive-compulsive disorder and panic disorder with agoraphobia. (12652634)
2003
40
Natriuretic peptides and panic disorder: therapeutic prospects. (19810905)
2003
41
Australian and New Zealand clinical practice guidelines for the treatment of panic disorder and agoraphobia. (14636376)
2003
42
No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder. (11244486)
2001
43
Moclobemide for anxiety disorders: a focus on moclobemide for panic disorder. (9466172)
1997
44
The panic-inducing properties of the cholecystokinin tetrapeptide CCK4 in patients with panic disorder. (8880078)
1996
45
Imipramine treatment of panic disorder with agoraphobia: the second time around. (8515390)
1993
46
The phenomenology of panic attacks in panic disorder with and without agoraphobia. (8425389)
1993
47
5-HT1A receptor-effector system responsivity in panic disorder. (1346719)
1992
48
Sleep studies and neurochemical correlates in panic disorder and agoraphobia. (2293254)
1990
49
Depression and panic anxiety: the effect of depressive co-morbidity on response to drug treatment of patients with panic disorder and agoraphobia. (1980697)
1990
50
Breathing retraining, exposure and a combination of both, in the treatment of panic disorder with agoraphobia. (2575375)
1989

Genetic Variations for Panic Disorder

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Expression for genes affiliated with Panic Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Panic Disorder

Search GEO for disease gene expression data for Panic Disorder.

Pathways for genes affiliated with Panic Disorder

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB
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Pathways related to Panic Disorder according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7ADORA2A, CCKAR, CCKBR, CCK, HTR1A, HTR2A
2
Hide members
10.7CCKAR, CCKBR, CCK, HTR1A, HTR2A, CRH
310.6HTR1A, HTR2A, MAOA, SLC6A4, TPH1, TPH2
4
Hide members
10.6COMT, HTR1A, HTR2A, MAOA, SLC6A4
5
Hide members
10.6CCKAR, CCKBR, CCK, HTR2A, TRH
610.6CCKAR, CCKBR, HTR2A, ADORA2A
7
Hide members
10.6SLC6A4, MAOA, HTR2A, HTR1A
810.6SLC6A4, SLC6A2, ADORA2A, TPH2
910.5ADORA2A, HTR2A, CCKBR
10
Hide members
10.5MAOA, TPH1, TPH2
11
Hide members
10.5TPH2, TPH1, MAOA
12
Hide members
10.5MAOA, COMT
13
Hide members
10.5SLC6A2, SLC6A4
14
Hide members
10.5TPH2, TPH1
15
Hide members
10.5TPH1, TPH2
16
Hide members
10.5TPH2, TPH1

Compounds for genes affiliated with Panic Disorder

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Panic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 267)
idCompoundScoreTop Affiliating Genes
1dopamine44 28 11 2414.3COMT, TPH1, CCKAR, CCKBR, CCK, ADORA2A
2norepinephrine44 11 2413.2GHRH, CRH, HTR2A, HTR1A, CCK, COMT
35-hydroxytryptamine4411.2TSPO, SLC6A2, SLC6A4, MAOA, CRH, HTR2A
4gaba4411.2TPH1, ADORA2A, TSPO, PTK7, SLC6A2, SLC6A4
5cocaine44 1112.1TRH, CRH, CCK, CCKBR, CCKAR, COMT
6glutamate4411.1COMT, CCKBR, CCK, CRH, TRH, MAOA
7haloperidol44 28 2 49 1115.1CCKAR, CCKBR, HTR1A, HTR2A, SLC6A4, SLC6A2
8benzodiazepine4411.1TSPO, PTK7, MAOA, CCK, CCKBR, CCKAR
9fenfluramine28 44 1113.1CCK, HTR1A, HTR2A, CRH, GHRH, TPH2
10fluoxetine49 44 28 1114.1TPH2, TPH1, SLC6A2, HTR1A, HTR2A, CRH
11maoa4411.1COMT, SLC6A2, TPH2, TPH1, SLC6A4, MAOA
12citalopram49 44 11 2414.1TPH1, PTK7, SLC6A2, SLC6A4, MAOA, HTR2A
13levodopa44 1112.1TSPO, TPH1, ADORA2A, COMT, MAOA, TRH
14clomipramine44 49 1113.1TSPO, SLC6A2, SLC6A4, MAOA, CRH, HTR1A
15acetylcholine44 49 28 11 2415.1CCK, CRH, TRH, CCKBR, TPH1, ADORA2A
16fluvoxamine44 49 1113.1HTR1A, HTR2A, SLC6A4, SLC6A2, TSPO, TPH1
17nicotine44 49 28 1114.1MAOA, CRH, SLC6A4, SLC6A2, TPH1, CCKBR
18paroxetine44 49 28 1114.0SLC6A2, COMT, HTR1A, HTR2A, MAOA, SLC6A4
19desipramine44 49 1113.0MAOA, TRH, SLC6A2, CRH, HTR2A, SLC6A4
205-hydroxytryptophan4411.0PTK7, TPH1, CRH, SLC6A4, HTR2A, HTR1A
21homovanillic acid44 2412.0SLC6A2, SLC6A4, CRH, COMT, MAOA, TPH1
22amine4411.0ADORA2A, TRH, SLC6A4, COMT, MAOA, SLC6A2
23benzodiazepines4411.0TSPO, CCKAR, CCKBR, CCK, MAOA
24amphetamine44 1112.0CCKBR, CCK, SLC6A4, SLC6A2, TPH1, MAOA
25mptp4411.0ADORA2A, SLC6A2, MAOA, COMT, SLC6A4, TSPO
26mdma4411.0MAOA, SLC6A4, HTR1A, SLC6A2, TPH1
27mhpg4411.0COMT, MAOA, SLC6A4, SLC6A2, CRH
28octreotide44 59 28 1114.0CCKBR, CCKAR, CCK, CRH, GHRH, TRH
29mianserin28 44 1112.9HTR2A, HTR1A, MAOA, SLC6A4, SLC6A2
30sertraline44 28 49 11 2414.9HTR1A, CRH, SLC6A2, SLC6A4, MAOA
31opiate4410.9ADORA2A, CRH, CCK, SLC6A4, TSPO, GHRH
32venlafaxine49 44 11 2413.9SLC6A2, SLC6A4, HTR1A, HTR2A, TPH2
33propranolol44 28 49 11 2414.9COMT, HTR1A, CRH, PTK7, TSPO, GHRH
34acth4410.9CCKBR, CCK, HTR1A, CRH, GHRH, TRH
355-hydroxyindoleacetic acid44 2411.9SLC6A2, TPH1, MAOA, CRH, SLC6A4
36carbon-114410.9SLC6A4, MAOA, HTR1A, TSPO
37p-chloroamphetamine4410.9SLC6A4, SLC6A2, MAOA, HTR1A
38morphine44 49 28 1113.8COMT, CCK, TRH, CCKAR, CCKBR, TSPO
39MMDA1110.8SLC6A2, SLC6A4, MAOA, HTR2A
40estrogen4410.8TSPO, TPH1, TPH2, SLC6A2, SLC6A4, MAOA
41spec-t4410.8CRH, SLC6A4, TSPO, ADORA2A, SLC6A2
42d amphetamine4410.8SLC6A4, SLC6A2, TSPO, MAOA
43raclopride44 2811.8CCKBR, CCK, HTR1A, HTR2A
44amitriptyline44 49 28 1113.8SLC6A4, MAOA, SLC6A2, HTR2A, HTR1A
45bromocriptine28 44 1112.7HTR1A, COMT, HTR2A, GHRH, TRH
46naloxone44 49 28 1113.7CCK, TRH, TSPO, CRH, GHRH
47nmda44 2811.6CCKBR, COMT, MAOA, TSPO, ADORA2A, HTR1A
48escitalopram44 49 11 2413.6HTR2A, SLC6A2, HTR1A, SLC6A4
49methamphetamine44 49 1112.5SLC6A4, MAOA, TPH1, SLC6A2, COMT
50antidepressants4910.3HTR1A, HTR2A, TPH1, TPH2

GO Terms for genes affiliated with Panic Disorder

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Sources:
16Gene Ontology
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Cellular components related to Panic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.7ADORA2A, PTK7, SLC6A2, SLC6A4, HTR2A, HTR1A

Biological processes related to Panic Disorder according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1response to drugGO:04249311.0ADORA2A, TSPO, SLC6A4, CRH, HTR2A, COMT
2positive regulation of cell proliferationGO:00828411.0GHRH, CRH, HTR2A, HTR1A, CCK, CCKBR
3response to painGO:04826510.9COMT, CRH, SLC6A2
4eating behaviorGO:04275510.9CCK, TRH, ADORA2A
5feeding behaviorGO:00763110.9CCKAR, CCKBR, CRH
6regulation of serotonin secretionGO:01406210.9CRH, HTR1A
7cholecystokinin signaling pathwayGO:03818810.9CCKBR, CCKAR
8regulation of hormone secretionGO:04688310.8HTR1A, HTR2A
9synaptic transmissionGO:00726810.8COMT, HTR2A, CRH, MAOA, SLC6A2
10serotonin biosynthetic processGO:04242710.8TPH1, TPH2
11dopamine catabolic processGO:04242010.8COMT, MAOA
12aromatic amino acid family metabolic processGO:00907210.8TPH1, TPH2
13circadian rhythmGO:00762310.8TPH2, TPH1, SLC6A4
14response to immobilization stressGO:03590210.8CRH, TPH1
15indolalkylamine biosynthetic processGO:04621910.7TPH2, TPH1
16positive regulation of mitochondrial depolarizationGO:05190110.7CCK, TSPO
17monoamine transportGO:01584410.7SLC6A4, SLC6A2
18neurotransmitter catabolic processGO:04213510.7MAOA, COMT
19sensory perceptionGO:00760010.6CCKBR, ADORA2A
20serotonin receptor signaling pathwayGO:00721010.6HTR1A, HTR2A
21regulation of behaviorGO:05079510.5HTR1A, HTR2A
22vasoconstrictionGO:04231010.5SLC6A4, HTR1A
23synaptic transmission, dopaminergicGO:00196310.4CRH, ADORA2A
24neurotransmitter biosynthetic processGO:04213610.2MAOA, COMT

Molecular functions related to Panic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00518410.5TRH, CRH, CCK
2monoamine transmembrane transporter activityGO:00850410.5SLC6A2, SLC6A4
3tryptophan 5-monooxygenase activityGO:00451010.4TPH2, TPH1
4cholecystokinin receptor activityGO:00495110.2CCKBR, CCKAR

Products for genes affiliated with Panic Disorder

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  • Antibodies
  • Proteins
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Sources for Panic Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet