MCID: PNN001
MIFTS: 53

Panniculitis malady

Summaries for Panniculitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the... more...

MalaCards: Panniculitis is related to pancreatitis and lupus erythematosus. An important gene associated with Panniculitis is TIA1 (TIA1 cytotoxic granule-associated RNA binding protein), and among its related pathways are Immune response IL-12-induced IFN-gamma production and IL-5 Signaling Pathway. The compounds estrogen and gold have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and pancreas, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Aliases & Classifications for Panniculitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Related Diseases for Panniculitis

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17GeneCards, 18GeneDecks
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Diseases related to Panniculitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 296)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.0SERPINA1
2lupus erythematosus31.0APOH
3systemic lupus erythematosus30.5IFNB1, IL2RB, ALOX5, APOH, IL2RA, FAS
4dermatitis30.4GZMB, ALOX5, IGHE
5cutaneous t cell lymphoma30.4NAV3
6arthritis30.3ALOX5, GZMB, IL2RB
7multiple sclerosis30.3IL2RB, IL2RA, IFNB1, ALOX5
8acute pancreatitis30.3SERPINA1
9rheumatoid arthritis30.3GZMB, TNFRSF8, APOH, FAS, IL2RA, SERPINA1
10vasculitis30.2SERPINA1, APOH
11hepatitis30.2IL2RB, GZMB, FAS, IFNB1, SERPINA1
12adenocarcinoma30.2IFNB1, NCAM1, BAX, FAS, BRAF, SERPINA1
13alopecia30.2AIRE
14leukemia30.2BAX, GZMB, TIA1, FAS, PSMB8, NCAM1
15glomerulonephritis30.1ALOX5
16acute leukemia30.1CSF3, NCAM1
17hemophagocytic lymphohistiocytosis30.0IL2RA, GZMB, NCAM1
18melanoma30.0SERPINA1, IL2RB, BAX, TIA1, BRAF, PSMB8
19uveitis29.9IL2RA
20peritonitis29.9ALOX5
21sarcoidosis29.9IL2RA, IL2RB, GZMB
22anaplastic large cell lymphoma29.9IL2RB, TNFRSF8, GZMB, IL2RA
23pancreatic cancer29.9FAS, NCAM1, BAX, ALOX5
24breast cancer29.9CSF3, TNFRSF8, SERPINA1, FAS, NCAM1, BAX
25vitiligo29.7AIRE
26candidiasis29.7AIRE
27bronchiolitis29.7IGHE
28sarcoma29.7BRAF
29diabetes mellitus29.7SERPINA1, AIRE
30nephrotic syndrome29.7SERPINA1, IL2RA
31skin disease29.7GZMB, IL2RA
32hepatitis b29.7GZMB, TNFRSF8, SERPINA1
33pneumonia29.7SERPINA1, IL2RB, CSF3
34autoimmune lymphoproliferative syndrome29.7FAS, IL2RA
35myositis29.7GZMB, NCAM1
36myeloid leukemia29.6FAS, BAX, CSF3
37aplastic anemia29.6GZMB, CSF3, FAS
38influenza29.6NAV3, IL2RB, IFNB1, GZMB
39primary biliary cirrhosis29.6IL2RB, GZMB, AIRE
40adenoma29.6TNFRSF8, BAX, BRAF
41infectious mononucleosis29.6IL2RB, TNFRSF8
42ischemia29.6BAX, ALOX5, IL2RB, NCAM1
43ulcerative colitis29.6IFNB1, SERPINA1, GZMB, IL2RA, ALOX5
44ovarian cancer29.6BAX, IFNB1, FAS, CSF3, BRAF
45tuberculosis29.6TNFRSF8, IL2RA, IFNB1, GZMB, SERPINA1, ALOX5
46prostate cancer29.6BAX, ALOX5, GZMB, NCAM1, FAS
47non-hodgkin lymphoma29.6GZMB, CSF3, TNFRSF8, FAS, IL2RA, IL2RB
48asthma29.6ALOX5, IL2RA, SERPINA1, TNFRSF8, GZMB, IFNB1
49hepatitis c29.6SERPINA1, FAS, IFNB1
50nodular nonsuppurative panniculitis10.6

Graphical network of the top 20 diseases related to Panniculitis:



Diseases related to panniculitis

Clinical Features for Panniculitis

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Drugs & Therapeutics for Panniculitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Panniculitis

Search CenterWatch for Panniculitis

Genetic Tests for Panniculitis

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Anatomical Context for Panniculitis

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32MalaCards
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MalaCards organs/tissues related to Panniculitis:

32
T cells, Skin, Pancreas, Breast, Liver, Colon, B cells, Kidney, Thyroid, Bone marrow, Bone, Brain, Myeloid, Lung, Prostate, Cervix, Nk cells

Animal Models for Panniculitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Panniculitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.7BRAF, IFNB1, AIRE
2MP:00053769.5ALOX5, AIRE, IGHE, CIDEC, APOH, IFNB1
3MP:00053848.8BRAF, IFNB1, GZMB, FAS, NCAM1, BAX
4MP:00053978.3ALOX5, TIA1, BRAF, IFNB1, GZMB, CSF3
5MP:00053878.3TNFRSF8, CSF3, GZMB, IFNB1, BRAF, TIA1

Publications for Panniculitis

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50PubMed
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Articles related to Panniculitis:

(show top 50)    (show all 646)
idTitleAuthorsYear
1
Pediatric subcutaneous panniculitis-like T-cell lymphoma with features of hemophagocytic syndrome. (23868752)
2013
2
Post-steroid panniculitis: A rare case report. (24350016)
2013
3
Post-surgical lipophagic panniculitis: a specific model of traumatic panniculitis and new histopathological findings. (23900165)
2013
4
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) with hemophagocytosis (HPS): successful treatment using high-dose chemotherapy (BFM-NHL & ALL-90) and autologous peripheral blood stem cell transplantation. (23995110)
2013
5
Lobular panniculitis and lipoatrophy of the thighs with interferon-A91a for intramuscular injection in a patient with multiple sclerosis. (22721889)
2012
6
Duodenitis associated with non-steroidal anti-inflammatory drug use causing mesenteric panniculitis. (22524738)
2012
7
Subcutaneous panniculitis-like T-cell lymphoma after rituximab. (23062926)
2012
8
Sandpaper dermatitis on a 17-month-old girl. Bacterial infectious panniculitis. (21482905)
2011
9
Cold panniculitis in Finnish horse riders. (21547345)
2011
10
Panniculitis ossificans traumatica of the lower leg. (22123193)
2011
11
Poststeroid panniculitis in an adult. (21915029)
2011
12
Factitious panniculitis induced by cupping therapy. (22134296)
2011
13
Fatal pancreatitis presenting as pancreatic panniculitis without enzyme elevation. (21521354)
2011
14
Mixed-cell granulomatous panniculitis on the cheek due to injection of solution containing phosphatidylcholine and deoxycholate. (20979342)
2010
15
Immunohistochemical localization of cellular NFATc1 does not predict clinical responses to ciclosporin in subcutaneous panniculitis-like T-cell non-Hodgkin lymphoma. (20096007)
2010
16
Tender erythematous plaques on the legs. Pancreatic panniculitis (PP). (20500185)
2010
17
Mesenteric panniculitis in Merseyside: a case series and a review of the literature. (20615306)
2010
18
Extranodal NK/T cell lymphoma, nasal type, presenting with primary cutaneous lesion mimicking granulomatous panniculitis: a case report and review of literature. (20718178)
2010
19
Lupus erythematosus panniculitis: clinicopathological, immunophenotypic, and molecular studies. (20098081)
2010
20
Paraneoplastic fasciitis-panniculitis syndrome: a neurological point of view. (19194391)
2009
21
Two cases of factitial panniculitis induced by electroacupuncture. (19094133)
2009
22
Relationship between abdominal trauma or surgery and mesenteric panniculitis. (20027693)
2009
23
Autologous peripheral blood stem cell transplantation to treat CHOP-refractory aggressive subcutaneous panniculitis-like T cell lymphoma. (19556752)
2009
24
Panniculitis as the initial manifestation of brucellosis: a case report. (18360123)
2008
25
Infective panniculitis. (18793979)
2008
26
Clinical and aetiopathogenic characteristics and prevalence of panniculitis in Turkey: a retrospective clinical study. (18311456)
2008
27
Cyclosporin in subcutaneous panniculitis-like T-cell lymphoma. (17454599)
2007
28
Recurrent neutrophilic panniculitis secondary to bacterial cystitis. (17324837)
2007
29
Dermatomyositis with panniculitis. (17215624)
2007
30
Panniculitis, polyarthritis and osteomyelitis associated with pancreatic neoplasia in two dogs. (16842278)
2006
31
Recurrent panniculitis in an adolescent boy with Prader-Willi syndrome. (17052066)
2006
32
Cutaneous zygomycosis associated with urate panniculitis. (16871036)
2006
33
A case of Rothmann-Makai panniculitis successfully treated with tetracycline. (16681577)
2006
34
Successful management of symptoms of steroid-dependent mesenteric panniculitis with colchicine. (16944021)
2006
35
Cytophagic hemorrhagic panniculitis and severe steatohepatitis: challenging combination. (16105145)
2005
36
Gouty panniculitis: a case report and review of the literature. (16144290)
2005
37
Alpha-1-antitrypsin deficiency-associated panniculitis. (15357757)
2004
38
Case number 31: Nodular panniculitis as expression of Munchausen's syndrome (panniculitis artefacta). (15361370)
2004
39
Q fever: a new cause of 'doughnut' granulomatous lobular panniculitis. (15377359)
2004
40
Panniculitis secondary to extravasation of clarithromycin in a patient with alpha 1-antitrypsin deficiency (phenotype PiZ). (12932253)
2003
41
Apoptosis and proliferation in subcutaneous panniculitis-like T-cell lymphoma. (12065776)
2002
42
Panniculitis mimicking lupus erythematosus profundus: a new histopathologic finding in malignant atrophic papulosis (Degos disease). (10446779)
1999
43
Nodular nonsuppurative panniculitis in association with primary biliary cirrhosis and Hashimoto's thyroiditis. (8686385)
1996
44
Acute exanthem and pancreatic panniculitis in a patient with primary HIV infection and haemophagocytic syndrome. (8733398)
1996
45
Factitial illness mimicking rheumatic disease with panniculitis. (19078034)
1996
46
Lupus erythematosus panniculitis with morphea-like lesions. (8313647)
1994
47
Cytophagic histiocytic panniculitis: a report of four cases. (1282361)
1992
48
Malignant histiocytosis with panniculitis--a case report. (2229645)
1990
49
Plasma cell panniculitis: a unique clinical and pathologic presentation of linear scleroderma. (2754069)
1989
50
Relapsing febrile nodular nonsuppurative panniculitis; report of case treated with penicillin. (18892290)
1948

Genetic Variations for Panniculitis

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Expression for genes affiliated with Panniculitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Panniculitis

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Pathways for genes affiliated with Panniculitis

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12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 29KEGG, 53Reactome, 4Cell Signaling Technology
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Pathways related to Panniculitis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1IL2RA, IL2RB, GZMB
210.0BAX, IL2RB, ALOX5
3
Apoptosis and survival Caspase cascade
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10.0FAS, BAX, GZMB
49.9BRAF, IL2RB, IL2RA, GZMB
5
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9.9IL2RA, IL2RB, FAS, GZMB
6
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9.9BRAF, BAX, IL2RA, IL2RB
7
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9.9IL2RB, BRAF, BAX, IL2RA
8
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9.9IL2RB, IL2RA, PSMB8, IFNB1
99.8IL2RA, IFNB1, IL2RB, CSF3
10
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9.7NCAM1, IL2RA, PSMB8, IL2RB, IFNB1
11
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9.7IL2RB, TNFRSF8, BAX, IL2RA, CSF3
12
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9.7BAX, IL2RA, IL2RB, CSF3, TNFRSF8
13
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9.6IGHE, FAS, IFNB1, BRAF, GZMB
149.6NCAM1, IL2RB, FAS, GZMB, ALOX5, IL2RA
15
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9.5IFNB1, IL2RB, IL2RA, IGHE, NCAM1, PSMB8
16
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9.4FAS, IFNB1, CSF3, TNFRSF8, BAX, IL2RA

Compounds for genes affiliated with Panniculitis

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB, 59Tocris Bioscience
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Compounds related to Panniculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8APOH
2gold4410.5APOH, IL2RB
3cycloheximide4410.5IL2RB, IFNB1
4beta-boswellic acid4410.4BAX, FAS, ALOX5
5glutamate4410.4APOH, ALOX5, NCAM1
6serine4410.3GZMB, ALOX5, NCAM1, IL2RB
7phosphatidylserine44 28 1112.3GZMB, APOH, BAX
8aspartate4410.2IGHE, BRAF, ALOX5, IL2RB
9ivig4410.2IGHE, APOH, IFNB1, IL2RB
102-chlorodeoxyadenosine4410.2CSF3, FAS, BAX, IL2RA
11alemtuzumab44 1111.2IL2RB, IL2RA, CSF3
12azathioprine44 49 2 1113.1IL2RB, IL2RA, GZMB, IFNB1, APOH
13neopterin4410.1GZMB, IL2RB, IFNB1, IL2RA
14ifn-alpha4410.1IL2RB, IL2RA, FAS, IFNB1
15infliximab44 49 1112.1IL2RB, FAS, IGHE, APOH, IL2RA
16Alpha-D-Mannose1110.1IFNB1, APOH, GZMB, IGHE
17agarose4410.1GZMB, APOH, FAS, BAX, SERPINA1
18levamisole44 1111.0IL2RA, IL2RB, IGHE
19dexamethasone44 49 28 1113.0GZMB, FAS, IGHE, ALOX5, IFNB1
20cytarabine44 49 1112.0BAX, IFNB1, GZMB, CSF3, FAS
21vincristine44 49 1112.0NCAM1, CSF3, BAX, IL2RA, IFNB1
22aspirin44 49 28 2413.0FAS, APOH, IL2RA, IL2RB, ALOX5
23paclitaxel44 49 1111.9IFNB1, BAX, CSF3, BRAF, FAS
24rantes449.9GZMB, IL2RA, IL2RB, IFNB1, FAS, CSF3
25ascorbic acid44 2410.9IL2RA, IGHE, SERPINA1
26etoposide44 49 59 1112.9IL2RA, CSF3, GZMB, IFNB1, FAS, BAX
27cyclophosphamide44 49 1111.9IFNB1, IGHE, IL2RB, CSF3, IL2RA, APOH
28methotrexate44 49 1111.9IL2RB, IL2RA, IFNB1, CSF3, APOH, IGHE
29n acetylcysteine449.9IGHE, BAX, IL2RA, FAS, IL2RB, ALOX5
30sb 20358044 5910.8FAS, BAX, AIRE, ALOX5, BRAF, IFNB1
31indomethacin44 59 28 1112.8IFNB1, ALOX5
325fluorouracil449.8CSF3, FAS, BAX, IL2RA, IFNB1
33genistein44 28 59 2 11 2414.8IFNB1, FAS, ALOX5, BAX, IL2RA, IL2RB
34creatinine449.7IFNB1, APOH, FAS, NCAM1, IGHE, SERPINA1
35polysaccharide449.7IL2RB, IL2RA, IGHE, NCAM1, SERPINA1, FAS
36doxorubicin44 49 1111.7IFNB1, IL2RA, FAS, CSF3, NCAM1, BAX
37cyclosporin a44 28 5911.7IL2RA, FAS, CSF3, GZMB, TNFRSF8, IL2RB
38prednisolone44 28 1111.7CSF3, FAS, IGHE, IL2RA, GZMB, IL2RB
39lactate449.7GZMB, APOH, IL2RB, FAS, NCAM1, IGHE
40heparin44 28 11 2412.7FAS, IFNB1, APOH, ALOX5, SERPINA1, IL2RA
41thymidine44 2410.7SERPINA1, IL2RB, IL2RA, TNFRSF8, FAS, IFNB1
42cisplatin44 49 59 1112.6BRAF, IFNB1, GZMB, CSF3, FAS, BAX
43epinephrine44 11 2411.6CSF3, FAS, IL2RA, IGHE, ALOX5
44arginine449.6APOH, FAS, IL2RA, GZMB, BRAF, IL2RB
45paraffin449.6SERPINA1, IL2RA, BAX, NCAM1, FAS, TNFRSF8
46phosphatidylinositol449.5BAX, BRAF, IL2RB, APOH, FAS, NCAM1
47retinoic acid44 2410.4GZMB, FAS, CSF3, IGHE, IFNB1, BRAF
48lipid449.2IFNB1, TNFRSF8, APOH, NCAM1, IL2RB, SERPINA1
49tyrosine449.1FAS, PSMB8, NCAM1, AIRE, IL2RA, IL2RB
50vegf449.0IL2RA, ALOX5, IL2RB, BAX, IGHE, NCAM1

GO Terms for genes affiliated with Panniculitis

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16Gene Ontology
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Cellular components related to Panniculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.9IL2RB, IL2RA, NCAM1, FAS

Biological processes related to Panniculitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cleavage of lamin involved in execution phase of apoptosisGO:00692210.3GZMB, BAX
2activation-induced cell death of T cellsGO:00692410.2IL2RA, FAS
3transformed cell apoptotic processGO:00692710.0BAX, FAS
4positive regulation of apoptotic processGO:0430659.8IL2RA, BAX, FAS, TNFRSF8
5cytokine-mediated signaling pathwayGO:0192219.8IL2RB, NCAM1, PSMB8, CSF3, IFNB1
6apoptotic processGO:0069159.7IL2RA, TIA1, GZMB, FAS, PSMB8, CIDEC
7activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.6IFNB1, FAS, BAX

Molecular functions related to Panniculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 bindingGO:01997610.2IL2RB, IL2RA
2interleukin-2 receptor activityGO:0049119.9IL2RB, IL2RA
3identical protein bindingGO:0428029.3SERPINA1, BRAF, APOH, FAS, NCAM1, BAX

Products for genes affiliated with Panniculitis

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Sources for Panniculitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet