Aliases & Classifications for Panniculitis

Summaries for Panniculitis

MalaCards based summary : Panniculitis is related to subcutaneous panniculitis-like t-cell lymphoma and peripheral t-cell lymphoma, and has symptoms including decreased adipose tissue, integumentary system signs and symptoms and myalgia. An important gene associated with Panniculitis is OTULIN (OTU Deubiquitinase With Linear Linkage Specificity), and among its related pathways/superpathways are Apoptosis and survival Caspase cascade and Apoptosis and Autophagy. The drugs Methyltestosterone and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and neutrophil, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 72 Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the... more...

Related Diseases for Panniculitis

Diseases related to Panniculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 292)
# Related Disease Score Top Affiliating Genes
1 subcutaneous panniculitis-like t-cell lymphoma 32.5 GZMB NAV3 NCAM1 TIA1 TRD
2 peripheral t-cell lymphoma 30.0 GZMB TIA1
3 cutaneous t cell lymphoma 29.1 GZMB IFNG TIA1
4 hemophagocytic lymphohistiocytosis 29.1 FAS GZMB IFNG
5 cytomegalovirus infection 28.7 FAS IFNG
6 nodular nonsuppurative panniculitis 12.6
7 lupus erythematosus panniculitis 12.3
8 autoinflammation, panniculitis, and dermatosis syndrome 12.2
9 cytophagic histiocytic panniculitis 12.1
10 infantile onset panniculitis with uveitis and systemic granulomatosis 12.0
11 lipodermatosclerosis 11.9
12 localized lipodystrophy 11.8
13 infantile-onset periodic fever-panniculitis-dermatosis syndrome 11.8
14 autoinflammation, lipodystrophy, and dermatosis syndrome 11.7
15 alpha-1-antitrypsin deficiency 11.4
16 igg4-related mesenteritis 11.3
17 peritonitis 11.3
18 acquired generalized lipodystrophy 11.2
19 autoimmune lymphoproliferative syndrome 10.9
20 erythema nodosum, idiopathic 10.9
21 lymphoma 10.6
22 pancreatitis 10.4
23 lichen sclerosus et atrophicus 10.4 GZMB TIA1
24 lymphomatoid granulomatosis 10.4 GZMB TIA1
25 viral esophagitis 10.4 GZMB TIA1
26 primary cutaneous anaplastic large cell lymphoma 10.4 GZMB TIA1
27 natural killer cell leukemia 10.4 GZMB TIA1
28 composite lymphoma 10.4 GZMB TIA1
29 hepatosplenic t-cell lymphoma 10.4 GZMB TIA1
30 lupus erythematosus 10.4
31 choriocarcinoma of the testis 10.4 GZMB TIA1
32 giardiasis 10.4 GZMB TIA1
33 lethal midline granuloma 10.3 NCAM1 TIA1
34 infiltrating lipoma 10.3 GZMB TIA1
35 necrotizing sialometaplasia 10.3 GZMB TIA1
36 rhinoscleroma 10.3 NCAM1 SERPINA1
37 t-cell large granular lymphocyte leukemia 10.3 GZMB NCAM1
38 cystadenofibroma 10.2 NCAM1 SERPINA1
39 lung lymphoma 10.2 GZMB NCAM1
40 plasma protein metabolism disease 10.2 BTK SERPINA1
41 acute necrotizing encephalitis 10.2 GZMB IFNG
42 orbit lymphoma 10.1 GZMB NCAM1 TIA1
43 b-cell expansion with nfkb and t-cell anergy 10.1 GZMB TIA1
44 parasitic ichthyosporea infectious disease 10.1 NCAM1 SERPINA1 TIA1
45 rhinosporidiosis 10.1 NCAM1 SERPINA1 TIA1
46 chronic active epstein-barr virus infection 10.1 IFNG TRD
47 dermatomyositis 10.1
48 erythema multiforme 10.1 GZMB IFNG
49 reticulosarcoma 10.0 GZMB TIA1
50 systemic lupus erythematosus 10.0

Graphical network of the top 20 diseases related to Panniculitis:



Diseases related to Panniculitis

Symptoms & Phenotypes for Panniculitis

UMLS symptoms related to Panniculitis:


decreased adipose tissue, integumentary system signs and symptoms, myalgia, pruritus, pain in limb, other musculoskeletal symptoms referable to limbs, exanthema

GenomeRNAi Phenotypes related to Panniculitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.64 GZMB NAV3 PSMB8 TIA1 FAS
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.64 FAS GZMB NAV3 PSMB8 TIA1 BTK

Drugs & Therapeutics for Panniculitis

Drugs for Panniculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyltestosterone Approved Phase 4 58-18-4 6010
2
Testosterone Approved, Investigational Phase 4 58-22-0 6013
3
Gemcitabine Approved Phase 4,Phase 1,Phase 2 95058-81-4 60750
4
Cisplatin Approved Phase 4 15663-27-1 2767 441203 84093
5
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
7
Epirubicin Approved Phase 4 56420-45-2 41867
8
Etoposide Approved Phase 4 33419-42-0 36462
9
Ifosfamide Approved Phase 4 3778-73-2 3690
10
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
11
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
12
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
13
Mechlorethamine Approved, Investigational Phase 4 51-75-2 4033
14
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
16
leucovorin Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-05-9 143 6006
17
Doxil Approved June 1999 Phase 4 31703
18
Pirarubicin Investigational Phase 4 72496-41-4
19 Anabolic Agents Phase 4
20 Androgens Phase 4
21 Antineoplastic Agents, Hormonal Phase 4
22 Hormone Antagonists Phase 4
23 Hormones Phase 4
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
25 insulin Phase 4
26 Insulin, Globin Zinc Phase 4
27 Testosterone 17 beta-cypionate Phase 4
28
Testosterone enanthate Phase 4 315-37-7 9416
29 Testosterone undecanoate Phase 4
30 Immunosuppressive Agents Phase 4,Phase 1,Phase 2
31 Antimetabolites Phase 4,Phase 1,Phase 2
32 Antimetabolites, Antineoplastic Phase 4,Phase 1,Phase 2
33 Folic Acid Antagonists Phase 4,Phase 1,Phase 2
34 Vitamin B Complex Phase 4,Phase 1,Phase 2
35 Alkylating Agents Phase 4
36 Anti-Bacterial Agents Phase 4,Phase 1
37 Antibiotics, Antitubercular Phase 4,Phase 1
38 Anti-Inflammatory Agents Phase 4
39 Antimitotic Agents Phase 4
40 Antineoplastic Agents, Phytogenic Phase 4
41 Antirheumatic Agents Phase 4,Phase 1
42 BB 1101 Phase 4
43 Dexamethasone acetate Phase 4 1177-87-3
44 Etoposide phosphate Phase 4
45 glucocorticoids Phase 4
46 Isophosphamide mustard Phase 4 0
47 Topoisomerase Inhibitors Phase 4
48 Dermatologic Agents Phase 4
49 Nucleic Acid Synthesis Inhibitors Phase 4
50 Folate Nutraceutical Phase 4,Phase 1,Phase 2

Interventional clinical trials:

(show all 16)

# Name Status NCT ID Phase Drugs
1 Testosterone Replacement in Metabolic Syndrome and Inflammation Completed NCT01123278 Phase 4 Testosterone;Placebo
2 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Recruiting NCT02533700 Phase 4 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
3 CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for Newly Diagnosed Young Patients With T Cell Lymphoma Active, not recruiting NCT01746992 Phase 4 Cyclophosphamide 750mg/m2;Vincristine 1.4mg/m2;Doxorubicin 50mg/m2;prednisone 60mg/m2;ifosfamide 2000mg/m2;pirarubicin 50mg/m2;pirarubicin 25mg/m2;Etoposide phosphate 100mg/m2;methotrexate 1500mg/m2
4 Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies Completed NCT00481871 Phase 1, Phase 2 Pralatrexate Injection;Gemcitabine Hydrochloride
5 Phase 1 Trial of Siplizumab and Dose-Adjusted EPOCH-Rituximab in T- and NK-Cell Lymphomas Active, not recruiting NCT01445535 Phase 1 EPOCH
6 Everolimus and Bortezomib in Treating Patients With Relapsed or Refractory Lymphoma Terminated NCT00671112 Phase 1 Bortezomib;Everolimus
7 Mesenteric Panniculitis : Review of Consecutive Abdominal MDCT Examinations With a Matched-pair Analysis Completed NCT03316001
8 Characterization of Transient Alterations of Cutaneous Sensory Nerve Function by Cryolipolysis Completed NCT01673113
9 Diet Induced Weight Loss to Reduce Inflammation in Obese Women Completed NCT01699906
10 GENETIC SUSCEPTIBILITY FACTOR AS A PREDICTOR OF TYPE 2 DIABETES REMISSION AND WEIGHT LOSS AFTER BARIATRIC SURGERY Completed NCT02405949
11 Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome Recruiting NCT01196845
12 T-Cell Project: Prospective Collection of Data in Patients With Peripheral T-Cell Lymphoma Recruiting NCT01142674
13 Leipzig Adipose Tissue Childhood Cohort Recruiting NCT02208141
14 Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma Recruiting NCT02652715
15 Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D Insufficiency Recruiting NCT01787409
16 Prospective Study of Functional and Quality of Life Outcomes in Panniculectomy Patients Terminated NCT01464658

Search NIH Clinical Center for Panniculitis

Cochrane evidence based reviews: panniculitis

Genetic Tests for Panniculitis

Genetic tests related to Panniculitis:

# Genetic test Affiliating Genes
1 Panniculitis 28

Anatomical Context for Panniculitis

MalaCards organs/tissues related to Panniculitis:

38
T Cells, Skin, Neutrophil, Pancreas, Breast, Bone, Liver

Publications for Panniculitis

Articles related to Panniculitis:

(show top 50) (show all 844)
# Title Authors Year
1
Analysis of Bacterial and Fungal Nucleic Acid in Canine Sterile Granulomatous and Pyogranulomatous Dermatitis and Panniculitis. ( 29145794 )
2018
2
An Autopsy Case of Mesenteric Panniculitis with Massive Pleural Effusions. ( 29298971 )
2018
3
Diffuse granulomatous panniculitis associated with anti PD-1 antibody therapy. ( 29296642 )
2018
4
Pancreatic panniculitis: the "bright" side of the moon in solid cancer patients. ( 29301491 )
2018
5
Septolobular panniculitis in disseminated Lyme borreliosis. ( 29293267 )
2018
6
Mesenteric Panniculitis-First Case Series After Bariatric Surgery. ( 29313276 )
2018
7
Livedo Racemosa, Reticulated Ulcerations, Panniculitis and Violaceous Plaques in a 46-year-old Woman. ( 29441299 )
2018
8
Board Review Vignette: PPP Syndrome: Pancreatitis, Panniculitis, Polyarthritis. ( 28741613 )
2017
9
Self-limiting Ibrutinib-Induced Neutrophilic Panniculitis. ( 28953011 )
2017
10
Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome: MRI features of intraosseous fat necrosis involving the feet and knees. ( 27928580 )
2017
11
Lupus panniculitis refractory to multiple therapies treated successfully with rituximab: A case report and literature review. ( 28856662 )
2017
12
Erythema nodosum-like panniculitis mimicking disease recurrence: A novel toxicity from immune checkpoint blockade therapy. Report of two patients. ( 28901560 )
2017
13
Pancreatic Panniculitis Sans Pancreatitis in a Patient with Diabetic Ketoacidosis. ( 28733691 )
2017
14
Pancreatic Panniculitis and Polyarthritis. ( 28844095 )
2017
15
An Atypical Presentation of Chronic Atrophic Gastritis: Hemolytic Anemia and Mesenteric Panniculitis. ( 28758037 )
2017
16
An Unexpected Etiology of Pancreatic Panniculitis: A Case Report. ( 29082362 )
2017
17
Panniculitis in the setting of dermato/rheumatologic diseases. ( 29249125 )
2017
18
Immunohistochemistry reveals an increased proportion of MYC-positive cells in subcutaneous panniculitis-like T-cell lymphoma compared with lupus panniculitis. ( 28800143 )
2017
19
Chronic lobular panniculitis after s.c. phosphatidylcholine. ( 28952149 )
2017
20
Anti-tumour necrosis factor I+-induced lupus erythematosus panniculitis. ( 28045205 )
2017
21
Bilateral ptosis as first presentation of cytophagic histiocytic panniculitis: a case report. ( 28666424 )
2017
22
An Overlooked Potentially Treatable Disorder: Idiopathic Mesenteric Panniculitis. ( 29073610 )
2017
23
CCR4 and CCR5 expression in a case of subcutaneous panniculitis-like T-cell lymphoma. ( 28721932 )
2017
24
Pancreatic Panniculitis. ( 28766564 )
2017
25
Remission of subcutaneous panniculitis-like T-cell lymphoma in a pregnant woman after treatment with oral corticosteroids as monotherapy. ( 28361107 )
2017
26
Recurrent mutations in epigenetic modifiers and the PI3K/AKT/mTOR pathway in subcutaneous panniculitis-like T-cell lymphoma. ( 28294301 )
2017
27
Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients: A case report. ( 29390478 )
2017
28
Successful treatment of hydroxyurea-associated panniculitis and vasculitis with low-dose methotrexate. ( 28932785 )
2017
29
Clinical characteristics, differential diagnosis, and treatment outcome of subcutaneous panniculitis-like T-cell lymphoma: a literature review of published Japanese cases. ( 28120776 )
2017
30
Subcutaneous panniculitis-like T-cell lymphoma. ( 28127142 )
2017
31
Mesenteric panniculitis. ( 28870885 )
2017
32
Sterile nodular panniculitis with lung and lymph node involvement in a Siberian tiger (Panthera tigris altica). ( 29081476 )
2017
33
Pancreatic acinar cell carcinoma presenting with panniculitis, successfully treated with FOLFIRINOX: A case report. ( 28588779 )
2017
34
Lupus erythematosus panniculitis resistant to standard treatment, complicated with macrophage activation syndrome. ( 28670262 )
2017
35
Subcutaneous Panniculitis-Like T-Cell Lymphoma Presenting as a Local Inflammation of a Thigh in an 8-Month-Old Child. ( 29085769 )
2017
36
An uncommon cause of panniculitis. ( 29230861 )
2017
37
Is there an association between mesenteric panniculitis and lymphoma? A case control analysis. ( 28712750 )
2017
38
Relapsed subcutaneous panniculitis-like T cell lymphoma: role of haploidentical hematopoietic stem cell transplant. ( 28879427 )
2017
39
Diagnosis of mesenteric panniculitis in the multi-detector computed tomography era. Association with malignancy and surgical history. ( 28917065 )
2017
40
Herpes infection: from skin to panniculitis involvement. ( 28895377 )
2017
41
Intravascular large B-cell lymphoma presenting as panniculitis. ( 29296641 )
2017
42
Exenatide-Induced Panniculitis: Utility of the Acid-Fast Stain to Identify Injected Microspheres. ( 28700374 )
2017
43
Erythema Nodosum-Like Panniculitis as a False-Positive 18F-FDG PET/CT in Advanced Melanoma Treated With Dabrafenib and Trametinib. ( 27775948 )
2017
44
Duplex Doppler Sonographic Assessment of the Superior Mesenteric Artery in Patients With Mesenteric Panniculitis. ( 28731594 )
2017
45
Subcutaneous panniculitis-like T-cell lymphoma with haemophagocytic syndrome during tocilizumab therapy for juvenile idiopathic arthritis. ( 28079502 )
2017
46
Severe panniculitis and polyarthritis caused by acinar cell carcinoma arising from an ectopic pancreas. ( 29167188 )
2017
47
Delayed-onset vemurafenib-induced panniculitis. ( 28879219 )
2017
48
Subcutaneous Panniculitis-like T Cell Lymphoma Mimicking Early-Onset Nodular Panniculitis. ( 27342380 )
2016
49
Lupus Erythematosus Panniculitis in Pregnancy and Antimalarials. ( 27293258 )
2016
50
Evaluation of Repairing Facial Depression Deformities Secondary to Lupus Erythematosus Panniculitis With Autologous Fat Grafting. ( 27648654 )
2016

Variations for Panniculitis

Expression for Panniculitis

Search GEO for disease gene expression data for Panniculitis.

Pathways for Panniculitis

GO Terms for Panniculitis

Biological processes related to Panniculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.02 BTK FAS GZMB IFNG TIA1
2 extrinsic apoptotic signaling pathway GO:0097191 8.96 FAS IFNG

Sources for Panniculitis

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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
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41 MeSH
42 MESH via Orphanet
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51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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