MCID: PNN001
MIFTS: 47

Panniculitis malady

Summaries for Panniculitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the... more...

MalaCards: Panniculitis is related to systemic lupus erythematosus and arthritis. An important gene associated with Panniculitis is TIA1 (TIA1 cytotoxic granule-associated RNA binding protein), and among its related pathways are Immune response IL-12-induced IFN-gamma production and IL-5 Signaling Pathway. The compounds estrogen and gold have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Aliases & Classifications for Panniculitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 27ICD9CM, 57SNOMED-CT, 25ICD10
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Related Diseases for Panniculitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Panniculitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 287)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus30.5IFNB1, APOH, FAS, IL2RA, IL2RB, ALOX5
2arthritis30.4GZMB, IL2RB, ALOX5
3vasculitis30.3SERPINA1, APOH
4adenocarcinoma30.3BRAF, IFNB1, FAS, NCAM1, BAX, SERPINA1
5acute pancreatitis30.2SERPINA1
6alopecia30.2AIRE
7acute leukemia30.2NCAM1, CSF3
8hemophagocytic lymphohistiocytosis30.1GZMB, NCAM1, IL2RA
9rheumatic disease30.1APOH, IL2RA, ALOX5
10peripheral t-cell lymphoma30.0TIA1, GZMB, TNFRSF8, NCAM1, IL2RA, IL2RB
11hepatitis c30.0SERPINA1, FAS, IFNB1
12uveitis29.9IL2RA
13anaplastic large cell lymphoma29.9IL2RB, IL2RA, TNFRSF8, GZMB
14asthma29.9IFNB1, GZMB, TNFRSF8, IGHE, IL2RA, SERPINA1
15vitiligo29.7AIRE
16pulmonary disease, chronic obstructive29.7SERPINA1
17bronchiolitis29.7IGHE
18nephritis29.7APOH
19polymyositis29.7GZMB, NCAM1
20autoimmune lymphoproliferative syndrome29.7IL2RA, FAS
21myelodysplastic syndromes29.7FAS, CSF3, GZMB
22lupus nephritis29.7APOH, IL2RA
23aplastic anemia29.7GZMB, CSF3, FAS
24primary biliary cirrhosis29.7IL2RB, AIRE, GZMB
25adenoma29.7BAX, TNFRSF8, BRAF
26infectious mononucleosis29.7TNFRSF8, IL2RB
27ulcerative colitis29.7IFNB1, GZMB, IL2RA, SERPINA1, ALOX5
28tuberculosis29.7IFNB1, GZMB, TNFRSF8, IL2RA, SERPINA1, ALOX5
29lupus erythematosus panniculitis10.7
30cytophagic histiocytic panniculitis10.7
31nodular nonsuppurative panniculitis10.6
32n syndrome10.5
33gout10.3
34lipodermatosclerosis10.3
35acinar cell carcinoma10.2
36discoid lupus erythematosus10.2
37cutaneous lupus erythematosus10.2
38hepatitis a10.2
39pediatric lymphoma10.1
40weber syndrome10.1
41subcutaneous panniculitis-like t-cell lymphoma10.1
42calciphylaxis10.1
43breast lymphoma10.1
44micro syndrome10.1
45cutaneous t cell lymphoma10.0NAV3
46cystic fibrosis10.0SERPINA1
47deficiency anemia10.0CSF3
48myasthenia gravis10.0AIRE
49lichen planus10.0GZMB
50malaria10.0IL2RB

Graphical network of the top 20 diseases related to Panniculitis:



Diseases related to panniculitis

Clinical Features for Panniculitis

Drugs & Therapeutics for Panniculitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Panniculitis

Search CenterWatch for Panniculitis

Genetic Tests for Panniculitis

Anatomical Context for Panniculitis

Animal Models for Panniculitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Panniculitis

Sources:
51PubMed
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Articles related to Panniculitis:

(show top 50)    (show all 646)
idTitleAuthorsYear
1
Eosinophil-rich granulomatous panniculitis caused by exenatide injection. (24224897)
2014
2
Panniculitis in alpha-1 antitrypsin deficiency treated with enzyme replacement. (22421127)
2012
3
Atypical lupus erythematosus panniculitis progressing to antinuclear antibody-negative systemic lupus erythematosus. (22971314)
2012
4
Lupus erythematosus panniculitis in children: report of three cases and review of previously reported cases. (22066977)
2012
5
Resolution of pancreatic panniculitis following metastasectomy. (22582914)
2012
6
Contribution of endermology to improving indurations and panniculitis/lipoatrophy at glatiramer acetate injection site. (22382874)
2012
7
Spontaneous resolution of severe, symptomatic mesocolic panniculitis: a case report. (22672224)
2012
8
Subcutaneous panniculitis-like T-cell lymphoma: a clinical and pathologic study of 14 korean patients. (21909203)
2011
9
Eosinophilic panniculitis triggered by intramuscular penicillin and occupational setting. (21284653)
2011
10
Liquefying panniculitis associated with intraductal papillary mucinous neoplasm. (21637399)
2011
11
Cold panniculitis following ice therapy for cardiac arrhythmia. (20738791)
2011
12
Hemophagocytic syndrome occurred in a patient with subcutaneous panniculitis-like T-cell lymphoma without overt skin lesion: successful treatment with steroid pulse therapy. (21545491)
2011
13
Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathologic study of 5 cases. (21623081)
2011
14
An illustrative case of subcutaneous panniculitis-like T-cell lymphoma. (21461360)
2011
15
Mesenteric panniculitis presenting with acute non-occlusive colonic ischemia. (21696596)
2011
16
Polyarthritis with chondronecrosis associated with osteonecrosis, panniculitis and pancreatitis. (19575201)
2010
17
Kimura's disease with eosinophilic panniculitis--treated with cyclosporine: a case report. (20236545)
2010
18
Histopathology of a granulomatous lobular panniculitis in acute Q fever: a case report. (19751228)
2010
19
An autosomal recessive syndrome of joint contractures, muscular atrophy, microcytic anemia, and panniculitis-associated lipodystrophy. (20534754)
2010
20
Lipoatrophic connective tissue panniculitis. (20199411)
2010
21
A case with two unusual findings: cutaneous leishmaniasis presenting as panniculitis and pericarditis after antimony therapy. (20465667)
2010
22
Interferon beta-induced panniculitis mimicking acute appendicitis. (19687423)
2009
23
Two cases of subcutaneous panniculitis-like T-cell lymphoma (CD4- CD8+ CD56-)]. (19328310)
2009
24
Necrotizing panniculitis: a skin condition associated with acinar cell carcinoma of the pancreas. (18414166)
2008
25
Molecular and ultrastructural studies of the fibrotic lesions of bovine focal proliferative fibrogranulomatous panniculitis (Lechiguana). (17492489)
2008
26
A complication of mesotherapy: noninfectious granulomatous panniculitis. (18559780)
2008
27
Disseminated panniculitis in a bottlenose dolphin (Tursiops truncatus) due to Mycobacterium chelonae infection. (18817005)
2008
28
Pancreatic panniculitis associated with acinar cell pancreatic carcinoma. (18258147)
2008
29
Extensive endarteritis obliterans in a case of lupus panniculitis with membranocystic changes and dystrophic calcification: a pathogenetic link? (17951149)
2007
30
Dermatomyositis, lobar panniculitis and inflammatory myopathy with abundant macrophages. (16809038)
2006
31
Necrobiotic panniculitis due to repeated insulin injection: a rare cause of a false positive somatostatin receptors scintigraphy. (17190024)
2006
32
Sclerodermic linear lupus panniculitis: report of two cases. (15942222)
2005
33
Topical capsaicin for the treatment of acute lipodermatosclerosis and lobular panniculitis. (16096187)
2005
34
Idiopathic nodular panniculitis in Niemann-Pick disease. (16164717)
2005
35
Clinical outcome of patients with subcutaneous panniculitis-like T-cell lymphoma. (16019507)
2005
36
Alpha1-antitrypsin deficiency-associated panniculitis: case report and review of treatment options. (15987301)
2005
37
Small vessel vasculitis and relapsing panniculitis in tumour necrosis factor receptor associated periodic syndrome (TRAPS). (15479908)
2004
38
Unusual case of subcutaneous panniculitis-like T-cell lymphoma. (15068459)
2004
39
A case of subcutaneous panniculitis-like T-cell lymphoma with haemophagocytosis developing secondary to chemotherapy. (15482305)
2004
40
Pentazocine-induced cutaneous sclerosis and panniculitis in an Indian male. (15230891)
2004
41
Intravascular large B-cell lymphoma presenting as cutaneous panniculitis. (14677722)
2003
42
Treatment of panniculitis associated with alpha-1-antitrypsin deficiency with alpha-1-protease inhibitor. (14690345)
2003
43
Alpha-1 antitrypsin deficiency panniculitis. (17657006)
2002
44
Subcutaneous panniculitis-like T-cell lymphoma: an elusive case presenting as lipomembranous panniculitis and a review of 72 cases in the literature. (11391101)
2001
45
Hepatosplenic and subcutaneous panniculitis-like gamma/delta T cell lymphomas are derived from different Vdelta subsets of gamma/delta T lymphocytes. (11272897)
2000
46
Membranocystic lesions in a patient with cytophagic histiocytic panniculitis associated with subcutaneous T-cell lymphoma. (9650702)
1998
47
Successful treatment of severe cytophagic histiocytic panniculitis with cyclosporine A. (8792512)
1996
48
Fatal systemic cytophagic histiocytic panniculitis: a histopathologic and immunohistochemical study of multiple organ sites. (7962745)
1994
49
Detection of Epstein-Barr virus genes in malignant lymphoma with clinical and histologic features of cytophagic histiocytic panniculitis. (8034809)
1994
50
A case of cytophagic histiocytic panniculitis with sicca symptoms and lupus nephritis. (1479116)
1992

Genetic Variations for Panniculitis

Expression for genes affiliated with Panniculitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Panniculitis

Search GEO for disease gene expression data for Panniculitis.

Pathways for genes affiliated with Panniculitis

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems, 52QIAGEN, 30KEGG, 54Reactome, 4Cell Signaling Technology
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Pathways related to Panniculitis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1IL2RA, IL2RB, GZMB
210.0BAX, IL2RB, ALOX5
3
Apoptosis and survival Caspase cascade
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10.0FAS, BAX, GZMB
49.9BRAF, IL2RB, IL2RA, GZMB
5
Hide members
9.9IL2RA, IL2RB, FAS, GZMB
6
Hide members
9.9BRAF, BAX, IL2RA, IL2RB
7
Hide members
9.9IL2RB, BRAF, BAX, IL2RA
8
Hide members
9.9IL2RB, IL2RA, PSMB8, IFNB1
99.8IL2RA, IFNB1, IL2RB, CSF3
10
Hide members
9.7NCAM1, IL2RA, PSMB8, IL2RB, IFNB1
11
Hide members
9.7IL2RB, TNFRSF8, BAX, IL2RA, CSF3
12
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9.7BAX, IL2RA, IL2RB, CSF3, TNFRSF8
13
Hide members
9.6IGHE, FAS, IFNB1, BRAF, GZMB
149.6NCAM1, IL2RB, FAS, GZMB, ALOX5, IL2RA
15
Hide members
9.5IFNB1, IL2RB, IL2RA, IGHE, NCAM1, PSMB8
16
Hide members
9.4FAS, IFNB1, CSF3, TNFRSF8, BAX, IL2RA

Compounds for genes affiliated with Panniculitis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 2BitterDB, 24HMDB, 60Tocris Bioscience
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Compounds related to Panniculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8APOH
2gold4510.5APOH, IL2RB
3cycloheximide4510.5IL2RB, IFNB1
4beta-boswellic acid4510.4BAX, FAS, ALOX5
5glutamate4510.4APOH, ALOX5, NCAM1
6serine4510.3GZMB, ALOX5, NCAM1, IL2RB
7phosphatidylserine45 29 1112.3GZMB, APOH, BAX
8aspartate4510.2IGHE, BRAF, ALOX5, IL2RB
9ivig4510.2IGHE, APOH, IFNB1, IL2RB
102-chlorodeoxyadenosine4510.2CSF3, FAS, BAX, IL2RA
11alemtuzumab45 1111.2IL2RB, IL2RA, CSF3
12azathioprine45 50 2 1113.1IL2RB, IL2RA, GZMB, IFNB1, APOH
13neopterin4510.1GZMB, IL2RB, IFNB1, IL2RA
14ifn-alpha4510.1IL2RB, IL2RA, FAS, IFNB1
15infliximab45 50 1112.1IL2RB, FAS, IGHE, APOH, IL2RA
16Alpha-D-Mannose1110.1IFNB1, APOH, GZMB, IGHE
17agarose4510.1GZMB, APOH, FAS, BAX, SERPINA1
18levamisole45 1111.0IL2RA, IL2RB, IGHE
19dexamethasone45 50 29 1113.0GZMB, FAS, IGHE, ALOX5, IFNB1
20cytarabine45 50 1112.0BAX, IFNB1, GZMB, CSF3, FAS
21vincristine45 50 1112.0NCAM1, CSF3, BAX, IL2RA, IFNB1
22aspirin45 50 29 2413.0FAS, APOH, IL2RA, IL2RB, ALOX5
23paclitaxel45 50 1111.9IFNB1, BAX, CSF3, BRAF, FAS
24rantes459.9GZMB, IL2RA, IL2RB, IFNB1, FAS, CSF3
25ascorbic acid45 2410.9IL2RA, IGHE, SERPINA1
26etoposide45 50 60 1112.9IL2RA, CSF3, GZMB, IFNB1, FAS, BAX
27cyclophosphamide45 50 1111.9IFNB1, IGHE, IL2RB, CSF3, IL2RA, APOH
28methotrexate45 50 1111.9IL2RB, IL2RA, IFNB1, CSF3, APOH, IGHE
29n acetylcysteine459.9IGHE, BAX, IL2RA, FAS, IL2RB, ALOX5
30sb 20358045 6010.8FAS, BAX, AIRE, ALOX5, BRAF, IFNB1
31indomethacin45 60 29 1112.8IFNB1, ALOX5
325fluorouracil459.8CSF3, FAS, BAX, IL2RA, IFNB1
33genistein45 29 60 2 11 2414.8IFNB1, FAS, ALOX5, BAX, IL2RA, IL2RB
34creatinine459.7IFNB1, APOH, FAS, NCAM1, IGHE, SERPINA1
35polysaccharide459.7IL2RB, IL2RA, IGHE, NCAM1, SERPINA1, FAS
36doxorubicin45 50 1111.7IFNB1, IL2RA, FAS, CSF3, NCAM1, BAX
37cyclosporin a45 29 6011.7IL2RA, FAS, CSF3, GZMB, TNFRSF8, IL2RB
38prednisolone45 29 1111.7CSF3, FAS, IGHE, IL2RA, GZMB, IL2RB
39lactate459.7GZMB, APOH, IL2RB, FAS, NCAM1, IGHE
40heparin45 29 11 2412.7FAS, IFNB1, APOH, ALOX5, SERPINA1, IL2RA
41thymidine45 2410.7SERPINA1, IL2RB, IL2RA, TNFRSF8, FAS, IFNB1
42cisplatin45 50 60 1112.6BRAF, IFNB1, GZMB, CSF3, FAS, BAX
43epinephrine45 11 2411.6CSF3, FAS, IL2RA, IGHE, ALOX5
44arginine459.6APOH, FAS, IL2RA, GZMB, BRAF, IL2RB
45paraffin459.6SERPINA1, IL2RA, BAX, NCAM1, FAS, TNFRSF8
46phosphatidylinositol459.5BAX, BRAF, IL2RB, APOH, FAS, NCAM1
47retinoic acid45 2410.4GZMB, FAS, CSF3, IGHE, IFNB1, BRAF
48lipid459.2IFNB1, TNFRSF8, APOH, NCAM1, IL2RB, SERPINA1
49tyrosine459.1FAS, PSMB8, NCAM1, AIRE, IL2RA, IL2RB
50vegf459.0IL2RA, ALOX5, IL2RB, BAX, IGHE, NCAM1

GO Terms for genes affiliated with Panniculitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Panniculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.9IL2RB, IL2RA, NCAM1, FAS

Biological processes related to Panniculitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cleavage of lamin involved in execution phase of apoptosisGO:00692210.3GZMB, BAX
2activation-induced cell death of T cellsGO:00692410.2IL2RA, FAS
3transformed cell apoptotic processGO:00692710.0BAX, FAS
4positive regulation of apoptotic processGO:0430659.8IL2RA, BAX, FAS, TNFRSF8
5cytokine-mediated signaling pathwayGO:0192219.8IL2RB, NCAM1, PSMB8, CSF3, IFNB1
6apoptotic processGO:0069159.7IL2RA, TIA1, GZMB, FAS, PSMB8, CIDEC
7activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.6IFNB1, FAS, BAX

Molecular functions related to Panniculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 bindingGO:01997610.2IL2RB, IL2RA
2interleukin-2 receptor activityGO:0049119.9IL2RB, IL2RA
3identical protein bindingGO:0428029.3SERPINA1, BRAF, APOH, FAS, NCAM1, BAX

Products for genes affiliated with Panniculitis

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Sources for Panniculitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet