MCID: PNN001
MIFTS: 53

Panniculitis malady

Summaries for Panniculitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the... more...

MalaCards: Panniculitis is related to pancreatitis and lupus erythematosus. An important gene associated with Panniculitis is TIA1 (TIA1 cytotoxic granule-associated RNA binding protein), and among its related pathways are Immune response IL-12-induced IFN-gamma production and IL-5 Signaling Pathway. The compounds estrogen and gold have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and pancreas, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Aliases & Classifications for Panniculitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Related Diseases for Panniculitis

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17GeneCards, 18GeneDecks
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Diseases related to Panniculitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 296)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.0SERPINA1
2lupus erythematosus31.0APOH
3systemic lupus erythematosus30.5IFNB1, IL2RB, ALOX5, APOH, IL2RA, FAS
4dermatitis30.4GZMB, ALOX5, IGHE
5cutaneous t cell lymphoma30.4NAV3
6arthritis30.3ALOX5, GZMB, IL2RB
7multiple sclerosis30.3IL2RB, IL2RA, IFNB1, ALOX5
8acute pancreatitis30.3SERPINA1
9rheumatoid arthritis30.3GZMB, TNFRSF8, APOH, FAS, IL2RA, SERPINA1
10vasculitis30.2SERPINA1, APOH
11hepatitis30.2IL2RB, GZMB, FAS, IFNB1, SERPINA1
12adenocarcinoma30.2IFNB1, NCAM1, BAX, FAS, BRAF, SERPINA1
13alopecia30.2AIRE
14leukemia30.2BAX, GZMB, TIA1, FAS, PSMB8, NCAM1
15glomerulonephritis30.1ALOX5
16acute leukemia30.1CSF3, NCAM1
17hemophagocytic lymphohistiocytosis30.0IL2RA, GZMB, NCAM1
18melanoma30.0SERPINA1, IL2RB, BAX, TIA1, BRAF, PSMB8
19uveitis29.9IL2RA
20peritonitis29.9ALOX5
21sarcoidosis29.9IL2RA, IL2RB, GZMB
22anaplastic large cell lymphoma29.9IL2RB, TNFRSF8, GZMB, IL2RA
23pancreatic cancer29.9FAS, NCAM1, BAX, ALOX5
24breast cancer29.9CSF3, TNFRSF8, SERPINA1, FAS, NCAM1, BAX
25vitiligo29.7AIRE
26candidiasis29.7AIRE
27bronchiolitis29.7IGHE
28sarcoma29.7BRAF
29diabetes mellitus29.7SERPINA1, AIRE
30nephrotic syndrome29.7SERPINA1, IL2RA
31skin disease29.7GZMB, IL2RA
32hepatitis b29.7GZMB, TNFRSF8, SERPINA1
33pneumonia29.7SERPINA1, IL2RB, CSF3
34autoimmune lymphoproliferative syndrome29.7FAS, IL2RA
35myositis29.7GZMB, NCAM1
36myeloid leukemia29.6FAS, BAX, CSF3
37aplastic anemia29.6GZMB, CSF3, FAS
38influenza29.6NAV3, IL2RB, IFNB1, GZMB
39primary biliary cirrhosis29.6IL2RB, GZMB, AIRE
40adenoma29.6TNFRSF8, BAX, BRAF
41infectious mononucleosis29.6IL2RB, TNFRSF8
42ischemia29.6BAX, ALOX5, IL2RB, NCAM1
43ulcerative colitis29.6IFNB1, SERPINA1, GZMB, IL2RA, ALOX5
44ovarian cancer29.6BAX, IFNB1, FAS, CSF3, BRAF
45tuberculosis29.6TNFRSF8, IL2RA, IFNB1, GZMB, SERPINA1, ALOX5
46prostate cancer29.6BAX, ALOX5, GZMB, NCAM1, FAS
47non-hodgkin lymphoma29.6GZMB, CSF3, TNFRSF8, FAS, IL2RA, IL2RB
48asthma29.6ALOX5, IL2RA, SERPINA1, TNFRSF8, GZMB, IFNB1
49hepatitis c29.6SERPINA1, FAS, IFNB1
50nodular nonsuppurative panniculitis10.6

Graphical network of the top 20 diseases related to Panniculitis:



Diseases related to panniculitis

Clinical Features for Panniculitis

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Drugs & Therapeutics for Panniculitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Panniculitis

Drug clinical trials:

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Search NIH Clinical Center for Panniculitis

Search CenterWatch for Panniculitis

Genetic Tests for Panniculitis

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Anatomical Context for Panniculitis

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32MalaCards
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MalaCards organs/tissues related to Panniculitis:

32
T cells, Skin, Pancreas, Breast, Liver, Colon, B cells, Kidney, Thyroid, Bone, Bone marrow, Lung, Brain, Prostate, Cervix, Myeloid, Nk cells

Animal Models for Panniculitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Panniculitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.7BRAF, IFNB1, AIRE
2MP:00053769.5ALOX5, AIRE, IGHE, CIDEC, APOH, IFNB1
3MP:00053848.8BRAF, IFNB1, GZMB, FAS, NCAM1, BAX
4MP:00053978.3ALOX5, TIA1, BRAF, IFNB1, GZMB, CSF3
5MP:00053878.3TNFRSF8, CSF3, GZMB, IFNB1, BRAF, TIA1

Publications for Panniculitis

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50PubMed
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Articles related to Panniculitis:

(show top 50)    (show all 646)
idTitleAuthorsYear
1
Macrophage activation syndrome leading to fatality in subcutaneous panniculitis-like T cell lymphoma. (23995578)
2013
2
Neutrophilic Lobular Panniculitis as an Expression of a Widened Spectrum of Familial Mediterranean Fever. (24369338)
2013
3
Outcome study of the surgical management of panniculitis. (21629099)
2012
4
Full facial edema: a novel presentation of subcutaneous panniculitis-like T-cell lymphoma. (22826278)
2012
5
Facticial panniculitis and LAPfgren's syndrome: a case. (22483663)
2012
6
Panniculitis associated with SjAPgren's syndrome. (22772624)
2012
7
Positron-emission tomography findings indicating the involvement of the whole body skin in subcutaneous panniculitis-like T cell lymphoma. (20972680)
2011
8
F-18 FDG PET images for subcutaneous panniculitis-like T-cell lymphoma. (21157218)
2011
9
Pancreatic panniculitis as the first manifestation of the pancreatic involvement during the course of a gastric adenocarcinoma. (20119689)
2011
10
Infant with facial lesions. Cold panniculitis. (21782555)
2011
11
Mesenteric panniculitis as a first manifestation of SchAPnlein-Henoch disease. (20935406)
2010
12
Multifocal granulomatous panniculitis with ceroid pigment in two Mediterranean striped dolphins (Stenella coeruleoalba). (20090053)
2010
13
Lupus panniculitis as an initial manifestation of systemic lupus erythematosus. (20418989)
2010
14
A Case of Sweet's Panniculitis Associated with Spinal Metastasis from Prostate Cancer. (21165226)
2010
15
Subcutaneous panniculitis-like T-cell lymphoma I+I^: complete sustained remission with corticosteroids and methotrexate. (20649797)
2010
16
Mesenteric panniculitis: a diagnosis of exclusion. (20575938)
2010
17
Subcutaneous panniculitis-like T-cell lymphoma in a child with trisomy 21. (21043561)
2010
18
New Findings in PiZZ alpha1-antitrypsin deficiency-related panniculitis. Demonstration of skin polymers and high dosing requirements of intravenous augmentation therapy. (19218787)
2009
19
Mesenteric panniculitis: an unusual cause of dyspepsia in a hemodialysis patient. (19203522)
2009
20
Idiopathic lobular panniculitis: remission induced and maintained with infliximab. (19519831)
2009
21
Granulomatous panniculitis associated with SjAPgren syndrome. (18559786)
2008
22
Lipomembranous panniculitis in a patient with acute leukemia induced by chemotherapy. (17915316)
2008
23
Education and imaging. Gastrointestinal: mesenteric panniculitis. (19120851)
2008
24
Factitial panniculitis. (18793986)
2008
25
Neutrophilic panniculitis in infancy: a cutaneous manifestation of juvenile rheumatoid arthritis. (17938028)
2007
26
Subcutaneous panniculitis-like T-cell lymphoma misdiagnosed as lupus erythematosus panniculitis. (16404499)
2007
27
Poststeroid panniculitis. (17997742)
2007
28
Acquired generalized lipodystrophy (panniculitis variety) triggered by pulmonary tuberculosis. (17651183)
2007
29
Lipomembranous panniculitis: report of a case. (17630113)
2007
30
Cutaneous gamma/delta T-cell lymphoma: a histopathologic mimicker of lupus erythematosus profundus (lupus panniculitis). (17367613)
2007
31
Mesenteric panniculitis and Erdheim-Chester disease: xanthogranulomatous diseases confused with malignancy. (17254937)
2007
32
Subcutaneous panniculitis lymphoma: erythema nodosum-like. (17229342)
2006
33
Fasciitis-panniculitis syndrome and advanced gastric adenocarcinoma in association with antibodies to single-stranded DNA. (16911303)
2006
34
High-dose chemotherapy with autologous blood stem cell transplantation for aggressive subcutaneous panniculitis-like T-cell lymphoma. (15858508)
2005
35
Subcutaneous Sweet's syndrome: a variant of acute febrile neutrophilic dermatosis that is included in the histopathologic differential diagnosis of neutrophilic panniculitis. (15858502)
2005
36
Panniculitis induced by a chemotherapy regimen consisting of topotecan and cyclophosphamide. (15368545)
2005
37
Disseminated cutaneous infection with Mycobacterium chelonae mimicking panniculitis in a patient with dermatomyositis. (16340031)
2005
38
Panniculitis and liver disease (hepatic Weber Christian disease). (15629524)
2005
39
Apomorphine-induced eosinophilic panniculitis and hypereosinophilia in Parkinson disease. (15668455)
2005
40
Coexistence of acquired localized hypertrichosis and lipoatrophy after lupus panniculitis. (15097972)
2004
41
Panniculitis due to non-tuberculous mycobacteria in two immunocompromised patients. (15844639)
2004
42
Pancreatic panniculitis in a patient with an acinar cell cystadenocarcinoma of the pancreas. (15118385)
2004
43
Cytotoxic gamma/delta subcutaneous panniculitis-like T-cell lymphoma: report of a case with pulmonary involvement unresponsive to therapy. (12705758)
2003
44
Cytophagic histiocytic panniculitis--a critical reappraisal. (10890995)
2000
45
Panniculitis of pancreatic disease masquerading as systemic lupus erythematosus panniculitis. (8596165)
1995
46
Calcifying panniculitis and kidney failure. Considerations on pathogenesis and treatment of calciphylaxis. (2737810)
1989
47
Lupus erythematosus panniculitis (Lupus profundus). (7438520)
1980
48
Lupus erythematosus panniculitis(profoundus). (294085)
1979
49
Nodular nonsuppurative panniculitis, Weber-Christian disease; report of a case in which an infiltrate of polymorphonuclear leukocytes represented the earliest lesion. (18110556)
1949
50
Nodular nonsuppurative panniculitis treated with penicillin. (21022539)
1946

Genetic Variations for Panniculitis

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Expression for genes affiliated with Panniculitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Panniculitis

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Pathways for genes affiliated with Panniculitis

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12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 29KEGG, 53Reactome, 4Cell Signaling Technology
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Pathways related to Panniculitis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1GZMB, IL2RA, IL2RB
210.0ALOX5, IL2RB, BAX
3
Apoptosis and survival Caspase cascade
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10.0BAX, FAS, GZMB
49.9BRAF, GZMB, IL2RA, IL2RB
5
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9.9IL2RB, IL2RA, FAS, GZMB
6
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9.9BRAF, BAX, IL2RA, IL2RB
7
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9.9BRAF, BAX, IL2RA, IL2RB
8
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9.9IL2RB, IL2RA, PSMB8, IFNB1
99.8IFNB1, CSF3, IL2RA, IL2RB
10
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9.7IL2RB, IL2RA, NCAM1, PSMB8, IFNB1
11
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9.7TNFRSF8, BAX, IL2RA, IL2RB, CSF3
12
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9.7CSF3, TNFRSF8, BAX, IL2RA, IL2RB
13
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9.6BRAF, IFNB1, GZMB, FAS, IGHE
149.6GZMB, FAS, NCAM1, IL2RA, IL2RB, ALOX5
15
Hide members
9.5IFNB1, PSMB8, NCAM1, IGHE, IL2RA, IL2RB
16
Hide members
9.4IL2RA, BAX, FAS, TNFRSF8, CSF3, IFNB1

Compounds for genes affiliated with Panniculitis

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB, 59Tocris Bioscience
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Compounds related to Panniculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8APOH
2gold4410.5APOH, IL2RB
3cycloheximide4410.5IL2RB, IFNB1
4beta-boswellic acid4410.4BAX, FAS, ALOX5
5glutamate4410.4APOH, ALOX5, NCAM1
6serine4410.3GZMB, ALOX5, NCAM1, IL2RB
7phosphatidylserine44 28 1112.3GZMB, APOH, BAX
8aspartate4410.2IGHE, BRAF, ALOX5, IL2RB
9ivig4410.2IGHE, APOH, IFNB1, IL2RB
102-chlorodeoxyadenosine4410.2CSF3, FAS, BAX, IL2RA
11alemtuzumab44 1111.2IL2RB, IL2RA, CSF3
12azathioprine44 49 2 1113.1IL2RB, IL2RA, GZMB, IFNB1, APOH
13neopterin4410.1GZMB, IL2RB, IFNB1, IL2RA
14ifn-alpha4410.1IL2RB, IL2RA, FAS, IFNB1
15infliximab44 49 1112.1IL2RB, FAS, IGHE, APOH, IL2RA
16Alpha-D-Mannose1110.1IFNB1, APOH, GZMB, IGHE
17agarose4410.1GZMB, APOH, FAS, BAX, SERPINA1
18levamisole44 1111.0IL2RA, IL2RB, IGHE
19dexamethasone44 49 28 1113.0GZMB, FAS, IGHE, ALOX5, IFNB1
20cytarabine44 49 1112.0BAX, IFNB1, GZMB, CSF3, FAS
21vincristine44 49 1112.0NCAM1, CSF3, BAX, IL2RA, IFNB1
22aspirin44 49 28 2413.0FAS, APOH, IL2RA, IL2RB, ALOX5
23paclitaxel44 49 1111.9IFNB1, BAX, CSF3, BRAF, FAS
24rantes449.9GZMB, IL2RA, IL2RB, IFNB1, FAS, CSF3
25ascorbic acid44 2410.9IL2RA, IGHE, SERPINA1
26etoposide44 49 59 1112.9IL2RA, CSF3, GZMB, IFNB1, FAS, BAX
27cyclophosphamide44 49 1111.9IFNB1, IGHE, IL2RB, CSF3, IL2RA, APOH
28methotrexate44 49 1111.9IL2RB, IL2RA, IFNB1, CSF3, APOH, IGHE
29n acetylcysteine449.9IGHE, BAX, IL2RA, FAS, IL2RB, ALOX5
30sb 20358044 5910.8FAS, BAX, AIRE, ALOX5, BRAF, IFNB1
31indomethacin44 59 28 1112.8IFNB1, ALOX5
325fluorouracil449.8CSF3, FAS, BAX, IL2RA, IFNB1
33genistein44 28 59 2 11 2414.8IFNB1, FAS, ALOX5, BAX, IL2RA, IL2RB
34creatinine449.7IFNB1, APOH, FAS, NCAM1, IGHE, SERPINA1
35polysaccharide449.7IL2RB, IL2RA, IGHE, NCAM1, SERPINA1, FAS
36doxorubicin44 49 1111.7IFNB1, IL2RA, FAS, CSF3, NCAM1, BAX
37cyclosporin a44 28 5911.7IL2RA, FAS, CSF3, GZMB, TNFRSF8, IL2RB
38prednisolone44 28 1111.7CSF3, FAS, IGHE, IL2RA, GZMB, IL2RB
39lactate449.7GZMB, APOH, IL2RB, FAS, NCAM1, IGHE
40heparin44 28 11 2412.7FAS, IFNB1, APOH, ALOX5, SERPINA1, IL2RA
41thymidine44 2410.7SERPINA1, IL2RB, IL2RA, TNFRSF8, FAS, IFNB1
42cisplatin44 49 59 1112.6BRAF, IFNB1, GZMB, CSF3, FAS, BAX
43epinephrine44 11 2411.6CSF3, FAS, IL2RA, IGHE, ALOX5
44arginine449.6APOH, FAS, IL2RA, GZMB, BRAF, IL2RB
45paraffin449.6SERPINA1, IL2RA, BAX, NCAM1, FAS, TNFRSF8
46phosphatidylinositol449.5BAX, BRAF, IL2RB, APOH, FAS, NCAM1
47retinoic acid44 2410.4GZMB, FAS, CSF3, IGHE, IFNB1, BRAF
48lipid449.2IFNB1, TNFRSF8, APOH, NCAM1, IL2RB, SERPINA1
49tyrosine449.1FAS, PSMB8, NCAM1, AIRE, IL2RA, IL2RB
50vegf449.0IL2RA, ALOX5, IL2RB, BAX, IGHE, NCAM1

GO Terms for genes affiliated with Panniculitis

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16Gene Ontology
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Cellular components related to Panniculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.9IL2RB, IL2RA, NCAM1, FAS

Biological processes related to Panniculitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cleavage of lamin involved in execution phase of apoptosisGO:00692210.3GZMB, BAX
2activation-induced cell death of T cellsGO:00692410.2IL2RA, FAS
3transformed cell apoptotic processGO:00692710.0BAX, FAS
4positive regulation of apoptotic processGO:0430659.8IL2RA, BAX, FAS, TNFRSF8
5cytokine-mediated signaling pathwayGO:0192219.8IL2RB, NCAM1, PSMB8, CSF3, IFNB1
6apoptotic processGO:0069159.7IL2RA, TIA1, GZMB, FAS, PSMB8, CIDEC
7activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.6IFNB1, FAS, BAX

Molecular functions related to Panniculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 bindingGO:01997610.2IL2RB, IL2RA
2interleukin-2 receptor activityGO:0049119.9IL2RB, IL2RA
3identical protein bindingGO:0428029.3SERPINA1, BRAF, APOH, FAS, NCAM1, BAX

Products for genes affiliated with Panniculitis

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Sources for Panniculitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet