MCID: PNN001
MIFTS: 47

Panniculitis malady

Skin diseases, Muscle diseases categories
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Summaries for Panniculitis

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Wikipedia:65 Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the... more...

MalaCards based summary: Panniculitis is related to pancreatitis and alopecia. An important gene associated with Panniculitis is TIA1 (TIA1 cytotoxic granule-associated RNA binding protein), and among its related pathways is Lymphocyte Signaling. The compounds [alcl] and neopterin have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and neutrophil, and related mouse phenotypes are cellular and mortality/aging.

Aliases & Classifications for Panniculitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Panniculitis

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Diseases related to Panniculitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 241)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.2SLC17A5, SERPINA1
2alopecia30.9AIRE
3acute pancreatitis30.4SLC17A5, SERPINA1
4hemophagocytic lymphohistiocytosis30.3GZMB, NCAM1
5hepatitis30.3SERPINA1, GZMB, SLC17A5
6b-cell lymphomas30.2GZMB, TIA1
7cutaneous t cell lymphoma30.1TIA1, GZMB
8melanoma30.0SERPINA1, TIA1, GZMB
9autoimmune hepatitis29.9AIRE, SLC17A5
10chronic obstructive pulmonary disease29.9SERPINA1, GZMB
11hepatitis c29.8SERPINA1, SLC17A5
12leukemia29.8GZMB, TIA1, NCAM1
13polymyositis29.8NCAM1, GZMB
14primary biliary cirrhosis29.7GZMB, AIRE, SLC17A5
15hepatitis b29.7SLC17A5, SERPINA1, GZMB
16peripheral t-cell lymphoma29.6TIA1, NCAM1, GZMB
17myopathy29.5NCAM1, SLC17A5
18myositis29.5NCAM1, GZMB, SLC17A5
19subcutaneous panniculitis-like t-cell lymphoma10.9
20lupus erythematosus10.7
21cytophagic histiocytic panniculitis10.7
22nodular nonsuppurative panniculitis10.7
23lupus erythematosus panniculitis10.7
24dermatomyositis10.4
25systemic lupus erythematosus10.4
26dermatitis10.4
27galactosemia10.3SERPINA1
28fasciitis10.3
29lipodermatosclerosis10.3
30arthritis10.3
31multiple sclerosis10.3
32lymphomatoid papulosis10.3TIA1, GZMB
33rheumatoid arthritis10.3
34reticulosarcoma10.2GZMB, TIA1
35mycosis fungoides10.2GZMB, TIA1
36alpha 1-antitrypsin deficiency10.2
37acinar cell carcinoma10.2
38adenocarcinoma10.2
39vasculitis10.2
40alopecia areata10.2AIRE, GZMB
41lipodystrophy10.2
42scleroderma10.2
43discoid lupus erythematosus10.2
44hodgkin's lymphoma10.1GZMB, TIA1
45glomerulonephritis10.1
46viral hepatitis10.1SLC17A5, SERPINA1
47cholestasis10.1SLC17A5, SERPINA1
48t-cell large granular lymphocyte leukemia10.1GZMB, NCAM1
49myelodysplastic syndromes10.1
50cutaneous lupus erythematosus10.1

Graphical network of the top 20 diseases related to Panniculitis:



Diseases related to panniculitis

Symptoms for Panniculitis

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Drugs & Therapeutics for Panniculitis

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Drug clinical trials:

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Genetic Tests for Panniculitis

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Anatomical Context for Panniculitis

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MalaCards organs/tissues related to Panniculitis:

32
T cells, Skin, Neutrophil, Pancreas, Breast, Liver, Colon, Kidney, B cells, Bone marrow, Bone, Thyroid, Brain, Lung, Prostate, Cervix, Myeloid, Nk cells

Animal Models for Panniculitis or affiliated genes

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MGI Mouse Phenotypes related to Panniculitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.1SLC17A5, GZMB, NCAM1, AIRE
2MP:00107687.3SLC17A5, GZMB, NCAM1, TIA1, AIRE

Publications for Panniculitis

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Articles related to Panniculitis:

(show top 50)    (show all 670)
idTitleAuthorsYear
1
Positron emission tomography of chronic panniculitis mimicking extranodal lymphoma. (25155405)
2014
2
Subcutaneous panniculitis-like T-cell lymphoma: MRI features and literature review. (24719040)
2014
3
Xanthogranulomatous cholecystitis-induced pancreatic panniculitis. (25088894)
2014
4
Aggressive Subcutaneous Panniculitis-Like CD30+ Peripheral T-Cell Lymphoma with Diffuse EBER Expression. (25143841)
2014
5
Mesenteric panniculitis in a patient with ankylosing spondylitis. (23523461)
2013
6
Pediatric subcutaneous panniculitis-like T-cell lymphoma with features of hemophagocytic syndrome. (23868752)
2013
7
Images in clinical medicine. Lobular panniculitis. (23363500)
2013
8
Post-steroid panniculitis: A rare case report. (24350016)
2013
9
Mesenteric panniculitis patients requiring emergency surgery: report of three cases. (22706750)
2012
10
Outcome study of the surgical management of panniculitis. (21629099)
2012
11
Pancreatic panniculitis. (22158400)
2012
12
Subcutaneous panniculitis-like T-cell lymphoma: successful treatment with systemic steroid alone. (22032642)
2012
13
Antiphospholipid-antibody-associated panniculitis. (23286808)
2012
14
Subcutaneous panniculitis-like T-cell lymphoma: a clinical and pathologic study of 14 korean patients. (21909203)
2011
15
Positron-emission tomography findings indicating the involvement of the whole body skin in subcutaneous panniculitis-like T cell lymphoma. (20972680)
2011
16
Multimodality imaging of subcutaneous panniculitis-like T-cell lymphoma. (21628950)
2011
17
Polyarthritis with chondronecrosis associated with osteonecrosis, panniculitis and pancreatitis. (19575201)
2010
18
Panniculitis ossificans non-traumatica of the scalp. (19615016)
2010
19
Inguinal panniculitis in a young Tasmanian devil (Sarcophilus harrisii) caused by Mycobacterium mageritense. (20529031)
2010
20
A case with an indolent course of subcutaneous panniculitis-like T-cell lymphoma demonstrating Epstein-Barr virus positivity and simulating dermatitis artefacta. (20141236)
2010
21
Intramedullary fat necrosis, polyarthritis and panniculitis with pancreatic tumor: a case report. (21199459)
2010
22
Anakinra for difficult-to-treat neutrophilic panniculitis: IL-1 blockade as a promising treatment option for neutrophil-mediated inflammatory skin disease. (20197651)
2010
23
Kimura's disease with eosinophilic panniculitis--treated with cyclosporine: a case report. (20236545)
2010
24
Mixed-cell granulomatous panniculitis on the cheek due to injection of solution containing phosphatidylcholine and deoxycholate. (20979342)
2010
25
Panniculitis in a patient presenting with a pancreatic tumour and polyarthritis: a case report. (19830189)
2009
26
New Findings in PiZZ alpha1-antitrypsin deficiency-related panniculitis. Demonstration of skin polymers and high dosing requirements of intravenous augmentation therapy. (19218787)
2009
27
Aggressive subcutaneous panniculitis-like T-cell lymphoma with hemophagocytosis in two children (subcutaneous panniculitis-like T-cell lymphoma). (19744747)
2009
28
Alfa-1-antitrypsin deficiency panniculitis acquired after liver transplant and successfully treated with retransplant. (19293031)
2009
29
Bartonella-associated meningoradiculoneuritis and dermatitis or panniculitis in 3 dogs. (18466250)
2008
30
Fungal panniculitis in renal transplant recipients. (18086276)
2008
31
alpha1-Antitrypsin deficiency presenting with panniculitis and incidental discovery of chronic obstructive pulmonary disease. (17910720)
2007
32
Cytophagic histiocytic panniculitis with fatal haemophagocytic lymphohistiocytosis in a paediatric patient with perforin gene mutation. (17601962)
2007
33
Dermatomyositis, lobar panniculitis and inflammatory myopathy with abundant macrophages. (16809038)
2006
34
Intraductal papillary mucinous adenoma of the pancreas presenting with lobular panniculitis. (16273371)
2006
35
Panniculitis, polyarthritis and osteomyelitis associated with pancreatic neoplasia in two dogs. (16842278)
2006
36
Subcutaneous panniculitis lymphoma: erythema nodosum-like. (17229342)
2006
37
Fibrotic involution of sural muscles secondary to lupus panniculitis. (15895908)
2005
38
Lupus panniculitis involving the parotid/periparotid regions and breast; a rare presentation. (15762074)
2004
39
Small vessel vasculitis and relapsing panniculitis in tumour necrosis factor receptor associated periodic syndrome (TRAPS). (15479908)
2004
40
Coexistence of acquired localized hypertrichosis and lipoatrophy after lupus panniculitis. (15097972)
2004
41
Cytotoxic gamma/delta subcutaneous panniculitis-like T-cell lymphoma: report of a case with pulmonary involvement unresponsive to therapy. (12705758)
2003
42
Subcutaneous lymphoid hyperplasia arising at site of ethnic scarifications and mimicking subcutaneous panniculitis-like T-cell lymphoma. (11315627)
2001
43
Aggressive subcutaneous panniculitis-like T-cell lymphoma: complete remission with fludarabine, mitoxantrone and dexamethasone. (10951154)
2000
44
Cytophagic histiocytic panniculitis and subcutaneous panniculitis-like T-cell lymphoma: report of 7 cases. (10890991)
2000
45
Membranocystic lesions in a patient with cytophagic histiocytic panniculitis associated with subcutaneous T-cell lymphoma. (9650702)
1998
46
Nodular nonsuppurative panniculitis in association with primary biliary cirrhosis and Hashimoto's thyroiditis. (8686385)
1996
47
Treatment of alpha-1-antitrypsin deficiency, massive edema, and panniculitis with alpha-1 protease inhibitor. (8849167)
1996
48
Generalized proteolysis in a young woman with Weber-Christian disease (nodular nonsuppurative panniculitis). (1215832)
1975
49
Chronic relapsing febrile nodular nonsuppurative panniculitis (Weber-Christian disease); relation to rheumatic fever and allied diseases. (14780325)
1950
50
Relapsing febrile nodular nonsuppurative panniculitis; report of case treated with penicillin. (18892290)
1948

Variations for Panniculitis

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Expression for genes affiliated with Panniculitis

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Expression patterns in normal tissues for genes affiliated with Panniculitis

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Pathways for genes affiliated with Panniculitis

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Pathways related to Panniculitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2GZMB, NCAM1

Compounds for genes affiliated with Panniculitis

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 50PharmGKB
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Compounds related to Panniculitis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1[alcl]4410.0TIA1, GZMB
2neopterin449.7SLC17A5, GZMB
3agarose449.7SERPINA1, GZMB
4hyaluronic acid44 2410.6SLC17A5, GZMB
5gold449.4GZMB, NCAM1
6nacl449.4SLC17A5, GZMB
7prednisolone44 28 1111.4SLC17A5, GZMB, TIA1
8hematoxylin449.3SLC17A5, NCAM1
9purine44 2410.3NCAM1, SLC17A5
10valproic acid44 50 24 1112.3SLC17A5, NCAM1
11heparan sulfate44 2410.3NCAM1, GZMB
12sialic acid449.3SLC17A5, NCAM1
13tacrolimus44 50 1111.1SLC17A5, GZMB
14oxygen44 2410.0SERPINA1, GZMB, SLC17A5
15lactate448.9SLC17A5, GZMB, NCAM1
16glutamate448.8NCAM1, GZMB, SLC17A5
17creatinine448.8SERPINA1, NCAM1, SLC17A5
18alanine448.8SLC17A5, GZMB, NCAM1
19estrogen448.8GZMB, NCAM1, SERPINA1
20glucose448.8SERPINA1, GZMB, SLC17A5
21cysteine448.7GZMB, NCAM1, SERPINA1
22paraffin448.6TIA1, SERPINA1, NCAM1, GZMB
23atp44 289.5SLC17A5, GZMB, NCAM1, TIA1
24ethanol44 50 24 1111.4SLC17A5, GZMB, NCAM1, SERPINA1
25heparin44 28 24 1111.4SERPINA1, NCAM1, GZMB, SLC17A5
26nitric oxide44 24 1110.4SERPINA1, NCAM1, GZMB, SLC17A5
27lipid448.4SLC17A5, GZMB, NCAM1, SERPINA1
28serine448.1AIRE, TIA1, SERPINA1, NCAM1, GZMB
29tyrosine447.9AIRE, SERPINA1, NCAM1, GZMB, SLC17A5

GO Terms for genes affiliated with Panniculitis

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Molecular functions related to Panniculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428028.6NCAM1, SERPINA1, AIRE

Products for genes affiliated with Panniculitis

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Sources for Panniculitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet