MCID: PNN001
MIFTS: 51

Panniculitis malady

Categories: Skin diseases, Muscle diseases

Aliases & Classifications for Panniculitis

Summaries for Panniculitis

MalaCards based summary : Panniculitis is related to nodular nonsuppurative panniculitis and lupus erythematosus panniculitis, and has symptoms including exanthema, other musculoskeletal symptoms referable to limbs and pain in limb. An important gene associated with Panniculitis is TIA1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Allograft rejection. The drugs Gemcitabine and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and neutrophil, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Wikipedia : 71 Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the... more...

Related Diseases for Panniculitis

Diseases related to Panniculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
id Related Disease Score Top Affiliating Genes
1 nodular nonsuppurative panniculitis 12.4
2 lupus erythematosus panniculitis 12.2
3 subcutaneous panniculitis-like t-cell lymphoma 12.1
4 cytophagic histiocytic panniculitis 12.0
5 infantile onset panniculitis with uveitis and systemic granulomatosis 11.9
6 lipodermatosclerosis 11.7
7 otulipenia 11.6
8 autoinflammation, lipodystrophy, and dermatosis syndrome 11.5
9 localized lipodystrophy 11.2
10 peritonitis 11.2
11 jmp syndrome 10.9
12 igg4-related mesenteritis 10.9
13 autoimmune lymphoproliferative syndrome 10.8
14 emphysema due to aat deficiency 10.8
15 erythema nodosum, idiopathic 10.8
16 lymphoma 10.5
17 pancreatitis 10.3
18 lupus erythematosus 10.3
19 malignant glioma 10.3 GZMB TIA1
20 tibial adamantinoma 10.2 GZMB TIA1
21 collagen type iii glomerulopathy 10.2 GZMB TIA1
22 fibrosclerosis of breast 10.2 GZMB TIA1
23 uterine ligament endometrioid adenocarcinoma 10.2 GZMB TIA1
24 occipital lobe neoplasm 10.2 NCAM1 TIA1
25 congenital sucrase-isomaltase deficiency with starch and lactose intolerance 10.2 GZMB TIA1
26 linear lichen planus 10.2 GZMB TIA1
27 cerebral lipidosis 10.2 GZMB TIA1
28 post-transplant lymphoproliferative disease 10.2 GZMB TIA1
29 subungual glomus tumor 10.2 GZMB IFNG
30 histiocytic and dendritic cell cancer 10.2 FASLG GZMB
31 pneumocystosis 10.1 NCAM1 SERPINA1
32 childhood immature teratoma of ovary 10.1 GZMB TIA1
33 alström syndrome 10.1 GZMB NCAM1 TIA1
34 alkhurma hemorrhagic fever 10.1 NCAM1 SERPINA1 TIA1
35 cutaneous ganglioneuroma 10.1 NCAM1 SERPINA1 TIA1
36 hemangioma of intra-abdominal structure 10.1 FASLG IFNG
37 plasmodium ovale malaria 10.1 GZMB TIA1
38 malignant teratoma 10.1 FASLG GZMB TIA1
39 hyperaldosteronism, familial, type ii 10.1 FASLG GZMB TIA1
40 pre-malignant neoplasm 10.1 GZMB IFNG TIA1
41 midline interhemispheric variant of holoprosencephaly 10.0 FAS FASLG
42 adenylosuccinase lyase deficiency 10.0 FASLG GZMB NCAM1
43 chronic thromboembolic pulmonary hypertension 10.0 IFNG TRD
44 venezuelan hemorrhagic fever 10.0 FASLG GZMB IFNG
45 acute myeloid leukemia with recurrent genetic anomaly 10.0 FASLG GZMB IFNG
46 carnitine-acylcarnitine translocase deficiency 10.0 FAS GZMB TIA1
47 dermatomyositis 10.0
48 superior limbic keratoconjunctivitis 10.0 GZMB NCAM1 TIA1 TRD
49 periodontosis 10.0 FASLG GZMB IFNG
50 trabecular follicular adenocarcinoma 10.0 FAS FASLG

Graphical network of the top 20 diseases related to Panniculitis:



Diseases related to Panniculitis

Symptoms & Phenotypes for Panniculitis

UMLS symptoms related to Panniculitis:


exanthema, other musculoskeletal symptoms referable to limbs, pain in limb, pruritus, myalgia, integumentary system signs and symptoms, decreased adipose tissue

GenomeRNAi Phenotypes related to Panniculitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.64 PSMB8 TIA1 BAX FAS GZMB
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.64 TIA1 BAX FAS FASLG GZMB PSMB8

MGI Mouse Phenotypes related to Panniculitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 BAX FAS FASLG IFNG OTULIN PSMB8
2 neoplasm MP:0002006 9.35 BAX FAS FASLG IFNG PSMB8
3 skeleton MP:0005390 9.1 BAX FAS FASLG IFNG OTULIN TIA1

Drugs & Therapeutics for Panniculitis

Drugs for Panniculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 4,Phase 1,Phase 2 95058-81-4 60750
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
4
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
5
Etoposide Approved Phase 4 33419-42-0 36462
6
Cisplatin Approved Phase 4 15663-27-1 84093 441203 2767
7
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
8
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
9
Ifosfamide Approved Phase 4 3778-73-2 3690
10
Mechlorethamine Approved Phase 4 51-75-2 4033
11
Epirubicin Approved Phase 4 56420-45-2 41867
12
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
13
leucovorin Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-05-9 54575, 6560146 143
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
15
Pirarubicin Investigational Phase 4 72496-41-4
16
Doxil Approved June 1999 Phase 4 31703
17 Folic Acid Antagonists Phase 4,Phase 1,Phase 2
18 Vitamin B Complex Phase 4,Phase 1,Phase 2
19 Immunosuppressive Agents Phase 4,Phase 1,Phase 2
20 Antimetabolites Phase 4,Phase 1,Phase 2
21 Antimetabolites, Antineoplastic Phase 4,Phase 1,Phase 2
22 Dexamethasone acetate Phase 4 1177-87-3
23 Alkylating Agents Phase 4
24 glucocorticoids Phase 4
25 Topoisomerase Inhibitors Phase 4
26 Nucleic Acid Synthesis Inhibitors Phase 4
27 Dermatologic Agents Phase 4
28 Hormone Antagonists Phase 4
29 Dexamethasone 21-phosphate Phase 4
30 Hormones Phase 4
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
32 Anti-Bacterial Agents Phase 4,Phase 1
33 Etoposide phosphate Phase 4
34 Anti-Inflammatory Agents Phase 4
35 Isophosphamide mustard Phase 4
36 Antibiotics, Antitubercular Phase 4,Phase 1
37 Antimitotic Agents Phase 4
38 Antirheumatic Agents Phase 4,Phase 1
39 Antineoplastic Agents, Alkylating Phase 4
40 BB 1101 Phase 4
41 Antineoplastic Agents, Hormonal Phase 4
42 Antineoplastic Agents, Phytogenic Phase 4
43 Folate Nutraceutical Phase 4,Phase 1,Phase 2
44 Vitamin B9 Nutraceutical Phase 4,Phase 1,Phase 2
45
Hydroxocobalamin Approved Phase 1, Phase 2 13422-51-0 11953898 5460373 44475014
46
Cyanocobalamin Approved, Nutraceutical Phase 1, Phase 2 68-19-9 44176380
47 Hematinics Phase 1, Phase 2
48 Trace Elements Phase 1, Phase 2
49 Vitamin B 12 Phase 1, Phase 2
50 Vitamins Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Recruiting NCT02533700 Phase 4
2 CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for Newly Diagnosed Young Patients With T Cell Lymphoma Recruiting NCT01746992 Phase 4
3 Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies Completed NCT00481871 Phase 1, Phase 2
4 Phase 1 Trial of Siplizumab and Dose-Adjusted EPOCH-Rituximab in T- and NK-Cell Lymphomas Active, not recruiting NCT01445535 Phase 1
5 Everolimus and Bortezomib in Treating Patients With Relapsed or Refractory Lymphoma Terminated NCT00671112 Phase 1
6 Characterization of Transient Alterations of Cutaneous Sensory Nerve Function by Cryolipolysis Completed NCT01673113
7 T-Cell Project: Prospective Collection of Data in Patients With Peripheral T-Cell Lymphoma Recruiting NCT01142674
8 Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma Recruiting NCT02652715
9 Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D Insufficiency Recruiting NCT01787409
10 Prospective Study of Functional and Quality of Life Outcomes in Panniculectomy Patients Terminated NCT01464658

Search NIH Clinical Center for Panniculitis

Cochrane evidence based reviews: panniculitis

Genetic Tests for Panniculitis

Genetic tests related to Panniculitis:

id Genetic test Affiliating Genes
1 Panniculitis 29

Anatomical Context for Panniculitis

MalaCards organs/tissues related to Panniculitis:

39
T Cells, Skin, Neutrophil, Breast, Pancreas, Liver, Kidney

Publications for Panniculitis

Articles related to Panniculitis:

(show top 50) (show all 801)
id Title Authors Year
1
Anti-tumour necrosis factor I+-induced lupus erythematosus panniculitis. ( 28045205 )
2017
2
Subcutaneous panniculitis-like T-cell lymphoma with haemophagocytic syndrome during tocilizumab therapy for juvenile idiopathic arthritis. ( 28079502 )
2017
3
Erythema Nodosum-Like Panniculitis as a False-Positive 18F-FDG PET/CT in Advanced Melanoma Treated With Dabrafenib and Trametinib. ( 27775948 )
2017
4
Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome: MRI features of intraosseous fat necrosis involving the feet and knees. ( 27928580 )
2017
5
Case report of subcutaneous panniculitis-like T-cell lymphoma complicated by eyelid swelling. ( 27440138 )
2016
6
Subcutaneous panniculitis like T-cell lymphoma in a case of sarcoidosis: A rare association. ( 27728564 )
2016
7
Mesenteric Panniculitis in a Thirteen-Year-Old Korean Boy Treated with Prednisolone: A Case Report. ( 27437192 )
2016
8
First report of tertiary syphilis presenting as lipoatrophic panniculitis in an immunocompetent patient. ( 27558164 )
2016
9
Clinical and histopathologic overlap between subcutaneous panniculitis-like T-cell lymphoma with systemic features and small cell CD8+ ALK+ systemic anaplastic large cell lymphoma with cutaneous involvement. ( 27060878 )
2016
10
Vemurafenib-Induced Neutrophilic Panniculitis: A New Case and Review of the Literature. ( 26959695 )
2016
11
Extensive Lipoatrophy on a Buttock Revealing Systemic Lupus Erythematosus Panniculitis. ( 26724319 )
2016
12
Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver - case report and review of literature. ( 26895632 )
2016
13
Purulent lupus panniculitis unmasked by FDG-PET/CT scan: A case report. ( 27902603 )
2016
14
Long-term remission of subcutaneous panniculitis-like T-cell lymphoma with central nervous system involvement: A case report. ( 27347188 )
2016
15
Neutrophilic panniculitis and autoinflammation: what's the link? ( 27035799 )
2016
16
Isolated omental panniculitis in a child with abdominal pain: case report. ( 27869425 )
2016
17
Perniosis/cold panniculitis in French equestrians: four cases. ( 27419657 )
2016
18
Lupus Erythematosus Panniculitis in Pregnancy and Antimalarials. ( 27293258 )
2016
19
Erythema Nodosum-like Septal Panniculitis Secondary to Lenalidomide Therapy in a Patient With Janus Kinase 2-Positive Myelofibrosis. ( 27538006 )
2016
20
Evaluation of Repairing Facial Depression Deformities Secondary to Lupus Erythematosus Panniculitis With Autologous Fat Grafting. ( 27648654 )
2016
21
Panniculitis is a common unrecognized histopathological feature of cutaneous leishmaniasis. ( 26960628 )
2016
22
Radiological features of a rare case of pancreatic panniculitis presenting in bilateral lower extremities. ( 27200166 )
2016
23
Recurrent lipoatrophic panniculitis of children. ( 27515780 )
2016
24
Pediatric subcutaneous panniculitis-like T-cell lymphoma presenting as paraparesis: An unreported manifestation. ( 27625250 )
2016
25
Pancreatic panniculitis preceding acute pancreatitis and subsequent detection of an intraductal papillary mucinous neoplasm: A case report. ( 27408933 )
2016
26
An Interesting Presentation of Ischemic Septal Panniculitis of the Breast. ( 27092964 )
2016
27
Subcutaneous Panniculitis-Like T-Cell Lymphoma: A Rare Tumour. ( 27437288 )
2016
28
Lipofilling: A New Therapeutic Option for the Treatment of Lupus Panniculitis-Induced Atrophy. ( 27920685 )
2016
29
Mesenteric panniculitis: systematic review of cross-sectional imaging findings and risk of subsequent malignancy. ( 27048526 )
2016
30
Pancreatic Panniculitis in an 18-Month-Old with Complete DiGeorge Syndrome. ( 27040037 )
2016
31
Repeated Panniculitis Induced by Pegylated Interferon Alpha 2a in a Patient with Chronic Hepatitis C. ( 27206440 )
2016
32
A Case of Scurvy-Uncommon Disease-Presenting as Panniculitis, Purpura, and Oligoarthritis. ( 27416817 )
2016
33
Pancreatic panniculitis as a paraneoplastic phenomenon of a pancreatic acinar cell carcinoma. ( 27112929 )
2016
34
Subcutaneous Panniculitis-like T Cell Lymphoma Mimicking Early-Onset Nodular Panniculitis. ( 27342380 )
2016
35
Differential diagnosis in neutrophilic lobular panniculitis. ( 27113011 )
2016
36
Pancreatic panniculitis associated with pancreatic carcinoma: A case report. ( 27495045 )
2016
37
Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography evaluation of subcutaneous panniculitis-like T cell lymphoma and treatment response. ( 27672640 )
2016
38
Lupus Panniculitis as an Initial Manifestation of Systemic Lupus Erythematosus: A Case Report. ( 27100438 )
2016
39
Kikuchi-Fujimoto Disease Associated With Subcutaneous Panniculitis-Like T-Cell Lymphoma. ( 26844615 )
2016
40
Cohort study of mesenteric panniculitis and its relationship to malignancy. ( 27515476 )
2016
41
Methotrexate-induced panniculitis in a patient with rheumatoid arthritis. ( 28006881 )
2016
42
Mesenteric Panniculitis (MP) in CT - A Predictor of Malignancy? ( 27529397 )
2016
43
Panniculitis in juvenile dermatomyositis: Report of a case and review of the published work. ( 26971888 )
2016
44
Hemophagocytic lymphohistiocytosis associated with subcutaneous panniculitis-like T-cell lymphoma. ( 27879081 )
2016
45
Case of lupus erythematosus panniculitis triggered by human papillomavirus quadrivalent vaccine injection. ( 28026034 )
2016
46
BRAFi-associated panniculitis - an emerging side effect with a variable histological picture: report of two cases and review of the literature. ( 27976808 )
2016
47
A case of Chagas' disease panniculitis after kidney transplantation. ( 27049374 )
2016
48
Atypical lymphocytic lobular panniculitis: an overlap condition with features of subcutaneous panniculitis-like T-cell lymphoma and lupus profundus. ( 27807018 )
2016
49
Subcutaneous panniculitis like T-cell lymphoma. ( 27728567 )
2016
50
Useful Parameters for Distinguishing Subcutaneous Panniculitis-like T-Cell Lymphoma From Lupus Erythematosus Panniculitis. ( 26796503 )
2016

Variations for Panniculitis

Expression for Panniculitis

Search GEO for disease gene expression data for Panniculitis.

Pathways for Panniculitis

Pathways related to Panniculitis according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 BAX FAS FASLG IFNG
2
Show member pathways
12.59 FAS FASLG GZMB IFNG
3
Show member pathways
12.54 BAX FAS FASLG GZMB
4
Show member pathways
12.27 FAS FASLG GZMB IFNG
5
Show member pathways
12.08 FAS FASLG OTULIN
6
Show member pathways
12.01 BAX FAS FASLG
7
Show member pathways
11.98 BAX FAS FASLG GZMB PSMB8
8
Show member pathways
11.92 FAS FASLG IFNG
9 11.92 BAX FAS FASLG GZMB TIA1
10
Show member pathways
11.74 FASLG GZMB IFNG
11 11.66 FAS FASLG GZMB IFNG NCAM1 OTULIN
12
Show member pathways
11.58 BAX FAS FASLG
13 11.54 GZMB IFNG NCAM1
14 11.47 BAX FAS FASLG
15
Show member pathways
11.37 FASLG GZMB IFNG
16 11.16 BAX FAS FASLG IFNG
17 11.11 BAX NCAM1
18 11.09 FAS FASLG IFNG
19
Show member pathways
10.86 FAS FASLG GZMB IFNG

GO Terms for Panniculitis

Cellular components related to Panniculitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 FAS FASLG IFNG NCAM1

Biological processes related to Panniculitis according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.78 BAX FAS FASLG IFNG
2 apoptotic process GO:0006915 9.73 BAX FAS FASLG GZMB IFNG TIA1
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.69 FAS FASLG PSMB8
4 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.63 BAX FAS FASLG
5 apoptotic signaling pathway GO:0097190 9.61 BAX FAS FASLG
6 neuron apoptotic process GO:0051402 9.57 BAX FAS
7 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.56 FAS FASLG
8 negative regulation of fibroblast proliferation GO:0048147 9.55 BAX IFNG
9 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.54 BAX FAS
10 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.54 BAX FAS FASLG
11 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.52 FAS FASLG
12 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 9.49 BAX FAS
13 necroptotic signaling pathway GO:0097527 9.4 FAS FASLG
14 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.33 BAX FAS FASLG
15 retinal cell programmed cell death GO:0046666 9.32 BAX FASLG
16 extrinsic apoptotic signaling pathway GO:0097191 9.26 BAX FAS FASLG IFNG
17 inflammatory cell apoptotic process GO:0006925 8.8 FAS FASLG IFNG

Sources for Panniculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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