Panniculitis malady

Wikipedia: Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the...⁴⁴ more...

MalaCards: Panniculitis is related to subcutaneous panniculitis-like t-cell lymphoma and lipodystrophy. An important gene associated with Panniculitis is TRG@ (T cell receptor gamma locus), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Lymphocyte Signaling. The compounds ivig and phosphatidylserine have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and t cells, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Aliases & Descriptions:

panniculitis 6 8 32 43

Diseases related to panniculitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 504)

id	Related Disease	Score	Top Affiliating Genes
1	subcutaneous panniculitis-like t-cell lymphoma	32.5	NAV3, GZMB, TRD@, TRG@
2	lipodystrophy	28.0	CIDEC, FAS, IGFBP3, TNF, PSMB8
3	alpha 1-antitrypsin deficiency	27.5	SERPINA1, IGHE, IFNG, TNF
4	autoimmune lymphoproliferative syndrome	27.2	IL2RA, FAS, IGHE
5	asthma	26.4	IFNG, ALOX5, TRG@, TNF
6	candidiasis	25.4	IL2RA, IGHE, IFNB1, IFNG, AIRE, CSF3
7	vasculitis	23.8	SERPINA1, IL2RA, APOH, FAS, IGHE, IFNB1
8	peritonitis	21.9	BAX, IL2RA, IL2RB, FAS, IGHE, IFNB1
9	multiple sclerosis	20.4	NCAM1, BAX, GZMB, IL2RA, IL2RB, APOH
10	lupus erythematosus	20.2	BAX, GZMB, IL2RA, IL2RB, APOH, FAS
11	anemia	19.9	NCAM1, NAV3, GZMB, IL2RA, IL2RB, APOH
12	pancreatitis	19.7	NCAM1, SERPINA1, BAX, IL2RA, IL2RB, APOH
13	composite lymphoma	13.5	GZMB, TNFRSF8, TIA1
14	posterior uveitis	13.3	IL2RA, IL2RB
15	pyomyositis	13.3	IGHE, CSF3
16	peripheral vertigo	13.3	APOH, F3
17	mycobacterium abscessus	13.3	SERPINA1, TNF
18	purpura fulminans	13.2	APOH, F3, CSF3
19	dyserythropoietic anemia with thrombocytopenia	13.1	GZMB, FAS, TIA1, CSF3
20	cluster headache	13.1	SERPINA1, IL2RA, IL2RB
21	diffuse infiltrative lymphocytosis syndrome	13.1	GZMB, IL2RA, IL2RB, TIA1
22	hematologic cancer	13.1	IL2RA, IL2RB, CSF3
23	protein c deficiency	13.1	APOH, F3, CSF3
24	21-hydroxylase deficiency	13.1	IL2RA, IL2RB, IFNB1
25	lymphomatoid papulosis	13.1	GZMB, FAS, TRG@, TNFRSF8, TIA1
26	hairy cell leukemia	13.1	IL2RA, IL2RB, IFNB1
27	retinal vasculitis	13.0	APOH, IFNB1, TNF
28	staphylococcal toxic shock syndrome	13.0	IGHE, TNF
29	type 1 diabetes mellitus	13.0	IGFBP3, AIRE, TRG@, PSMB8
30	hypereosinophilic syndrome	12.9	IL2RA, IGHE, TRD@
31	chronic active epstein-barr virus infection	12.9	IFNG, TRD@, TRG@
32	t-cell large granular lymphocyte leukemia	12.9	IL2RA, TRG@, TNF
33	coronary artery aneurysm	12.9	GZMB, IGHE, TNF
34	hepatitis	12.9	SERPINA1, GZMB, IL2RB, FAS, IFNB1
35	stevens-johnson syndrome	12.9	GZMB, FAS, TNF
36	iron deficiency anemia	12.9	IL2RB, TNF, CSF3
37	reticulosarcoma	12.9	GZMB, CASP3, TNFRSF8, TIA1
38	adult respiratory distress syndrome	12.9	ALOX5, TNF, CSF3
39	fournier gangrene	12.9	IGHE, F3
40	cowpox	12.8	GZMB, FAS, CASP3
41	erythema multiforme	12.8	FAS, F3, TNF
42	pemphigus foliaceus	12.8	BAX, FAS, TNF
43	systemic scleroderma	12.8	IL2RA, IL2RB, APOH, ALOX5
44	retinal vein occlusion	12.8	APOH, F3, TNF
45	hypergammaglobulinemia	12.8	IL2RA, FAS, IGHE
46	chronic venous leg ulcers	12.8	BAX, FAS, TNF
47	splenomegaly	12.8	IL2RA, FAS, CSF3
48	dermatitis herpetiformis	12.8	IL2RA, IL2RB, TNF
49	newcastle disease	12.8	BAX, IL2RB, IFNB1, TNF
50	fibromyalgia	12.8	SERPINA1, IGFBP3, TNF, PSMB8

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to panniculitis:

²²

MGI Mouse Phenotypes related to panniculitis:

²⁵ (show all 12)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	9.6	TRD@, AIRE, IFNG, CIDEC
2	hematopoietic system phenotype	MP:0005397	9.1	GZMB, CSF3, PSMB8, TIA1, TRG@, TRD@
3	digestive/alimentary phenotype	MP:0005381	8.7	TRG@, TRD@, AIRE, CASP3, IFNG
4	behavior/neurological phenotype	MP:0005386	8.3	AIRE, F3, IFNG, FAS, IL2RB, CIDEC
5	immune system phenotype	MP:0005387	8.1	TIA1, TNFRSF8, TNF, TRG@, TRD@, AIRE
6	tumorigenesis	MP:0002006	7.7	PSMB8, TNF, TRD@, AIRE, F3, IFNG
7	growth/size phenotype	MP:0005378	7.6	AIRE, CASP3, F3, FAS, IL2RB, IL2RA
8	integument phenotype	MP:0010771	7.5	CSF3, TNF, TRG@, TRD@, F3, IFNG
9	homeostasis/metabolism phenotype	MP:0005376	6.7	TRD@, AIRE, CASP3, ALOX5, F3, IFNB1
10	vision/eye phenotype	MP:0005391	6.7	TNF, AIRE, CASP3, F3, IFNG, FAS
11	mortality/aging	MP:0010768	5.6	TIA1, TNF, TRD@, AIRE, CASP3, F3
12	cellular phenotype	MP:0005384	5.3	ALOX5, CASP3, AIRE, TRD@, TRG@, TNF

Articles related to panniculitis:

(show all 27)

id	Title	Authors	Year	Affiliating Genes
1	PSMB8 encoding the I^5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-indu ced lipodystrophy syndrome. (21129723)	Agarwal A.K.... Garg A.	2010	PSMB8
2	Kimura's disease with eosinophilic panniculitis--trea ted with cyclosporine: a case report. (20236545)	Maleki D.... Gholami N.	2010	IGHE
3	New Findings in PiZZ alpha1-antitrypsin deficiency-re lated panniculitis. Demonstration of skin polymers and high dosing requirements of intravenous augmentation therapy. (19218787)	Gross B.... Janciauskiene S.	2009	SERPINA1
4	Subcutaneous panniculitis-like T-cell lymphoma with o verlapping clinicopathologic features of lupus erythematosus: coexistence of 2 entities? (19590424)	Pincus L.B.... Cerroni L.	2009	TRG@
5	Two cases of subcutaneous panniculitis-like T-cell l ymphoma (CD4- CD8+ CD56-) (19328310)	Springinsfeld G.... Cribier B.	2009	NCAM1
6	Clinicopathological characterization and genomic aberrations in subcutaneous panniculitis-like T-cell lymphoma. (18337827)	Hahtola S.... Ranki A.	2008	NAV3
7	Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathologic, immunophenotypic, and molecular study of 22 Asian cases according to WHO-EORTC classification. (18708940)	Kong Y.Y.... Shi D.R.	2008	TRD@, TRG@
8	A case of mesenteric panniculitis: multiple involvement of the emergency department before final diagnosis and appropriate treatment. (17496688)	Volpicelli G.... Saracco W.	2007	F3
9	Sclerodermic linear lupus panniculitis: report of two cases. (15942222)	Marzano A.V.... Alessi E.	2005	APOH
10	Recurrent panniculitis associated with generalized lipodystrophy and growth hormone deficiency. (16091831)	Hou J.W.... Huang S.F.	2005	IGFBP3
11	Small vessel vasculitis and relapsing panniculitis in tumour necrosis factor receptor associated periodic syndrome (TRAPS). (15479908)	Lamprecht P.... Gross W.L.	2004	TNF
12	Clinicopathologic differences between 22 cases of CD56-negative and CD56-positive subcutaneous panniculitis-like lymphoma in Japan. (14991542)	Takeshita M.... Kikuchi M.	2004	CASP3, BAX, FAS
13	Alpha-1-antitrypsin associated panniculitis: the MS variant. (15389208)	Geraminejad P.... VanBeek M.	2004	SERPINA1
14	Lupus-like panniculitis in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). (12951636)	FA1chtenbusch M.... Manns M.P.	2003	AIRE
15	Nasal-type natural killer cell lymphoma preceded by benign panniculitis arising in an asymptomatic HTLV-1 carrier. (12956685)	Kunisada M.... Iwatsuki K.	2003	TIA1
16	An ultrastructural study of cutaneous panniculitis-like T-cell lymphoma: cytoplasmic granules and active cellular and cell-to-matrix interaction mimic cytotoxic T-cells. (12184377)	Yamazaki K.	2002	GZMB, TNFRSF8, TIA1
17	Panniculitis after subcutaneous injection of interferon beta in a multiple sclerosis patient. (11872423)	Heinzerling L.... Schmid-Grendelmeier P.	2002	IFNB1
18	Subcutaneous panniculitis-like T-cell lymphoma: prese ntation of 2 cases and observations. (12521396)	Papenfuss J.S.... Armitage J.O.	2002	GZMB
19	Cytophagic histiocytic panniculitis and subcutaneous panniculitis-like T-cell lymphoma: report of 7 cases. (10890991)	Marzano A.V.... Caputo R.	2000	TRG@
20	Recurrent panniculitis in a man with asthma receiving treatment with leukotriene-modifying agents. (10852428)	Dellaripa P.F.... Drazen J.	2000	ALOX5
21	Hepatosplenic and subcutaneous panniculitis-like gamma/delta T cell lymphomas are derived from different Vdelta subsets of gamma/delta T lymphocytes. (11272897)	Przybylski G.K.... Salhany K.E.	2000	TRD@
22	Panniculitis, pancreatitis and very severe aplastic a nemia in childhood: a challenge to treat. (11131923)	Holstein T.... Burdach S.	2000	CSF3
23	Successful treatment of a patient with febrile, lobul ar panniculitis (Weber-Christian disease) with oral cyclosporin A: implications for pathogenesis and therapy. (10435371)	Iwasaki T.... Kakishita E.	1999	IL2RA, IFNG
24	alpha 1-antitrypsin deficiency-associated panniculitis: resolution with intravenous alpha 1-antitrypsin administration and liver transplantation. (9039946)	O'Riordan K.... Abecassis M.	1997	SERPINA1
25	Effective high-dose chemotherapy followed by autologo us peripheral blood stem cell transplantation in a patient with the aggressive form of cytophagic histiocytic panniculitis. (9244423)	Koizumi K.... Koike T.	1997	CSF3
26	Angiocentric immunoproliferative lesions of the skin show lobular panniculitis and are mainly disorders of large granular lymphocytes. (8522304)	Takeshita M.... Uike N.	1995	IL2RB
27	Angiocentric lymphoma with granulomatous panniculitis in the skin expressing natural killer cell and large granular T-cell phenotypes. (7850074)	Takeshita M.... Goto H.	1994	IL2RB

Genes related to panniculitis according to GeneCards:

(show all 26)

id	Symbol	Description	Score	GeneCards Section Context
1	TRG@	T cell receptor gamma locus	11.0	Publications
2	TRD@	T cell receptor delta locus	11.0	Publications
3	TIA1	TIA1 cytotoxic granule-associated RNA binding protein	11.0	Publications
4	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications
5	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
6	NAV3	neuron navigator 3	11.0	Publications
7	CIDEC	cell death-inducing DFFA-like effector c	11.0
8	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	11.0	Publications
9	AIRE	autoimmune regulator	11.0	Publications
10	ABHD6	abhydrolase domain containing 6	11.0
11	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	11.0	Publications
12	IL2RB	interleukin 2 receptor, beta	11.0	Publications
13	ALOX5	arachidonate 5-lipoxygenase	11.0	Publications
14	IFNB1	interferon, beta 1, fibroblast	11.0	Publications
15	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
16	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
17	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
18	BAX	BCL2-associated X protein	11.0	Publications
19	NCAM1	neural cell adhesion molecule 1	11.0	Publications
20	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
21	IGFBP3	insulin-like growth factor binding protein 3	11.0	Publications
22	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
23	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
24	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0	Publications
25	TNF	tumor necrosis factor	11.0	Publications
26	IFNG	interferon, gamma	11.0	Publications

Pathways related to panniculitis according to GeneDecks:

(show all 42)

id	Pathway	Score	Top Affiliating Genes
1	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.0	GZMB, IL2RA, IL2RB
2	Lymphocyte Signaling3	9.8	NCAM1, IL2RA, IL2RB
3	Molecular Mechanisms of Cancer36	9.6	BAX, CASP3, TNFRSF8
4	Apoptosis38	9.5	BAX, GZMB, TNF
5	Apoptosis and survival_FAS signaling cascades41	9.4	CASP3, FAS, BAX
6	Apoptosis and survival FAS signaling cascades10	9.4	CASP3, FAS, BAX
7	Apoptosis and Autophagy3	9.4	CASP3, FAS, GZMB, BAX
8	Cytokine Network36	9.2	IFNB1, IFNG, TNF
9	p53 signaling pathway20	9.1	CASP3, IGFBP3, FAS, BAX
10	African trypanosomiasis20	9.1	FAS, IFNG, TNF
11	14-3-3 and Regulation of BAD Activity36	9.0	TNF, CASP3, BAX
12	Jak-STAT signaling pathway20	9.0	CSF3, IFNG, IFNB1, IL2RB, IL2RA
13	Allograft rejection20	9.0	TNF, IFNG, FAS, GZMB
14	Type I diabetes mellitus20	9.0	TNF, IFNG, FAS, GZMB
15	Akt Signaling36	9.0	TNFRSF8, TNF, IL2RB, IL2RA
16	all-trans-Retinoic Acid Signaling in Brain36	9.0	CSF3, TNF, ALOX5, BAX
17	TNF-Induced Apoptosis Implicating Sphingolipids36	9.0	BAX, CASP3, TNF
18	Measles20	9.0	IFNG, IFNB1, FAS, IL2RB, IL2RA
19	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.0	TNF, FAS, IL2RB, IL2RA
20	Apoptotic Pathways Triggered By HIV136	8.9	TNF, CASP3, BAX
21	THC Differentiation Pathway36	8.9	TNF, IFNG, IL2RA
22	Chagas disease (American trypanosomiasis)20	8.8	TNF, IFNG, IFNB1, FAS
23	Apoptosis and survival_TNFR1 signaling pathway41	8.8	TNF, CASP3, BAX
24	Apoptosis and survival_Caspase cascade41	8.8	TNF, CASP3, FAS, BAX
25	Apoptosis and survival Caspase cascade10	8.8	TNF, CASP3, FAS, BAX
26	Apoptosis and survival_Apoptotic TNF-family pathways41	8.7	TNF, CASP3, FAS, BAX
27	Apoptosis and survival Apoptotic TNF-family pathways10	8.7	TNF, CASP3, FAS, BAX
28	Apoptosis and survival TNFR1 signaling pathway10	8.7	TNF, CASP3, BAX
29	Amyotrophic lateral sclerosis (ALS)20	8.7	BAX, CASP3, TNF
30	Apoptosis Signaling Pathways37	8.7	BAX, FAS, CASP3, TNF
31	Apoptosis20	8.7	BAX, FAS, CASP3, TNF
32	Bacterial infections in CF airways41	8.7	FAS, IFNG, TNF
33	Toxoplasmosis20	8.5	TNF, CASP3, ALOX5, IFNG
34	Malaria20	8.5	CSF3, TNF, IFNG
35	STAT3 Pathway36	8.5	CSF3, TNFRSF8, TNF, IL2RB, IL2RA, BAX
36	Antioxidant Action of Vitamin-C36	8.4	BAX, IL2RA, IL2RB, TNF, TNFRSF8, CSF3
37	Colorectal Cancer Metastasis36	8.3	BAX, IFNG, CASP3, TNF
38	Tuberculosis20	8.3	TNF, CASP3, IFNG, IFNB1, BAX
39	Natural killer cell mediated cytotoxicity20	8.1	TNF, CASP3, IFNG, IFNB1, FAS, GZMB
40	PAK Pathway36	8.0	CSF3, TNF, CASP3, IL2RA, BAX
41	p38 Signaling36	7.8	CSF3, TNFRSF8, TNF, CASP3, IL2RB, IL2RA
42	Cytokine-cytokine receptor interaction20	7.7	CSF3, TNFRSF8, TNF, IFNG, IFNB1, FAS

Compounds related to panniculitis according to GeneDecks:

(show top 50)    (show all 174)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.7	IFNB1
2	phosphatidylserine32 9 9	12.7	GZMB
3	cyclophosphamide32 34 9 9	13.6	APOH
4	aspartate32	9.9	ALOX5, IFNB1, IL2RB, GZMB
5	heparin32 9 18 9	12.9	ALOX5, F3, SERPINA1, NCAM1
6	etoposide32 42 9 9	12.4	FAS, GZMB, BAX, CASP3
7	aebsf32	9.4	TNF, F3
8	cyclosporin a32 42	10.3	GZMB, IL2RA, IL2RB, TNFRSF8, IGHE
9	azathioprine32 34 9 9	12.0	IL2RA, IL2RB, GZMB, IGFBP3, APOH, IFNB1
10	epinephrine32 9 18 9	12.0	ALOX5, F3, IGHE, IGFBP3, FAS
11	vegf32	8.8	APOH, IGFBP3, IFNB1, F3, ALOX5, CSF3
12	ifn-alpha32	8.8	IL2RA, IFNB1, IFNG, FAS, IL2RB
13	vesnarinone32	8.8	CSF3, TNF, IFNG, FAS
14	estrogen32	8.8	ALOX5, SERPINA1, IGHE, IGFBP3, APOH, GZMB
15	cytarabine32 34 9 9	11.7	IFNB1, CASP3, BAX, GZMB, FAS, CSF3
16	agarose32	8.7	BAX, SERPINA1, GZMB, APOH, FAS, CASP3
17	natalizumab32 9 9	10.6	IFNG, TNF, IFNB1, IL2RA
18	aspirin32 34 18	10.5	IL2RB, ALOX5, F3, FAS, APOH, IL2RA
19	paraffin32	8.5	SERPINA1, NCAM1, BAX, IL2RA, FAS, TNFRSF8
20	2,5-oligoadenylate32	8.4	TNF, IFNG, IFNB1, IL2RA, IL2RB
21	z-vad-fmk32 42	9.4	TNF, GZMB, BAX, CASP3
22	il 1032	8.4	IL2RB, IL2RA, IFNG, TNF, IFNB1
23	fluticasone propionate32 42 9 9	11.4	IGHE, IFNB1, IFNG, IGFBP3, TNF
24	okt332	8.4	IL2RA, FAS, IL2RB, IFNG, TNF
25	neopterin32	8.4	IFNG, IL2RB, IFNB1, TNF, GZMB, IL2RA
26	pentoxifylline32 9 9	10.3	IL2RA, IL2RB, IFNG, F3, TNF
27	sb 20358032 42	9.2	TNF, IFNB1, ALOX5, CASP3, IFNG, AIRE
28	endotoxin32	8.2	IL2RB, APOH, TNF, IFNB1, CSF3, IFNG
29	tacrolimus32 34 9 9	11.0	F3, IFNG, ALOX5, TNF, IL2RB, IL2RA
30	polysaccharide32	7.9	IGFBP3, NCAM1, F3, IFNB1, IGHE, IL2RB
31	herbimycin a32 42	8.9	IL2RA, FAS, IFNB1, IFNG, ALOX5, TNF
32	infliximab32 9 9	9.7	TNF, IL2RA, IGHE, FAS, APOH, IFNG
33	rantes32	7.7	CSF3, TNF, IL2RB, GZMB, IL2RA, FAS
34	doxorubicin32 34 9 9	10.7	BAX, IGFBP3, CSF3, IL2RA, NCAM1, FAS
35	methotrexate32 34 42 9 9	11.6	IL2RB, TNF, IFNB1, IGHE, IGFBP3, APOH
36	creatinine32	7.6	IGFBP3, IGHE, APOH, FAS, IL2RB, IL2RA
37	5fluorouracil32	7.6	IFNG, FAS, IGFBP3, CSF3, IFNB1, CASP3
38	cisplatin32 34 9 9	10.5	CASP3, IGFBP3, FAS, IFNB1, IL2RB, IL2RA
39	indomethacin32 9 9	9.5	IGHE, FAS, IFNG, TNF, ALOX5, IL2RA
40	paclitaxel32 34 9 9	10.4	FAS, CASP3, CSF3, BAX, IL2RA, IFNB1
41	n acetylcysteine32	7.3	TNF, CASP3, IGHE, IL2RB, BAX, IL2RA
42	lactate32	7.2	IGFBP3, GZMB, APOH, FAS, IL2RB, NCAM1
43	actinomycin d32	7.1	TNF, BAX, FAS, F3, IFNB1, IFNG
44	thymidine32 18	8.1	TNFRSF8, CSF3, SERPINA1, TNF, IFNG, IGFBP3
45	genistein32 9 18 9	10.0	IFNG, ALOX5, TNF, IFNB1, CASP3, IL2RA
46	prednisolone32 9 9	8.7	IGHE, IGFBP3, FAS, APOH, IL2RB, IL2RA
47	serine32	6.4	NCAM1, CASP3, SERPINA1, AIRE, ALOX5, GZMB
48	dexamethasone32 42 34 9 9	10.3	IFNG, ALOX5, TNF, CSF3, IGHE, IGFBP3
49	cycloheximide32	6.1	F3, IL2RB, BAX, FAS, IGFBP3, IGHE
50	retinoic acid32 42 18	7.8	GZMB, IL2RB, CASP3, F3, IFNG, IFNB1

Cellular components related to panniculitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	7.9	NCAM1, IL2RB, FAS, IFNG, TNF
2	extracellular space	GO:005615	7.4	TNF, F3, IFNG, IFNB1, IGFBP3, APOH

Biological processes related to panniculitis according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	cleavage of lamin	GO:006922	10.1	GZMB, BAX
2	interleukin-2-mediated signaling pathway	GO:038110	9.8	IL2RB, IL2RA
3	nuclear fragmentation involved in apoptotic nuclear change	GO:030264	9.8	BAX, CASP3
4	activation of pro-apoptotic gene products	GO:008633	9.6	BAX, GZMB, FAS
5	induction of apoptosis by intracellular signals	GO:008629	9.4	BAX, GZMB, CASP3
6	neuron apoptotic process	GO:051402	9.4	CASP3, FAS, BAX
7	positive regulation of vitamin D biosynthetic process	GO:060557	9.4	IFNG, TNF
8	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.3	TNF, IFNG
9	transformed cell apoptotic process	GO:006927	9.3	BAX, FAS, TNF
10	positive regulation of necrotic cell death	GO:010940	9.0	FAS, TNF
11	humoral immune response	GO:006959	9.0	IFNB1, IFNG, AIRE, TNF
12	induction of apoptosis via death domain receptors	GO:008625	8.9	TNF, CASP3, FAS
13	cytokine-mediated signaling pathway	GO:019221	8.9	CSF3, PSMB8, IFNG, IFNB1, IL2RB, NCAM1
14	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	8.7	TNF, F3, IFNB1, FAS, BAX
15	positive regulation of neuron apoptotic process	GO:043525	8.6	TNF, CASP3, BAX
16	positive regulation of apoptotic process	GO:043065	8.6	TNFRSF8, TNF, IGFBP3, FAS, BAX
17	induction of apoptosis by extracellular signals	GO:008624	8.5	BAX, FAS, CASP3, TNF
18	induction of apoptosis	GO:006917	8.1	CIDEC, TIA1, TNF, CASP3, IFNB1, FAS
19	apoptotic process	GO:006915	6.9	PSMB8, TIA1, TNF, CASP3, IFNG, FAS

Molecular functions related to panniculitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-2 receptor activity	GO:004911	9.6	IL2RA, IL2RB
2	protease binding	GO:002020	8.9	SERPINA1, F3, TNF
3	cytokine activity	GO:005125	8.6	IFNB1, IFNG, TNF, CSF3