MCID: PNV001
MIFTS: 42

Panuveitis malady

Summaries for Panuveitis

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32MalaCards
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MalaCards: Panuveitis, also known as inflammation of the whole uveal tract, is related to uveitis and vasculitis. An important gene associated with Panuveitis is IFNA2 (interferon, alpha 2), and among its related pathways are Immune response IFN alpha/beta signaling pathway and PEDF Induced Signaling. The compounds tacrolimus and pegasys have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and bone.

Aliases & Classifications for Panuveitis

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

panuveitis 8 42 44 60
inflammation of the whole uveal tract 42
diffuse uveitis 8


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Disease Ontology8 DOID:12030
ICD9CM27 360.12
SNOMED-CT56 75614007
MeSH34 D015864
NCIt39 C84989

Related Diseases for Panuveitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Panuveitis:



Diseases related to panuveitis

Clinical Features for Panuveitis

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Drugs & Therapeutics for Panuveitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Panuveitis

Drug clinical trials:

Search ClinicalTrials for Panuveitis

Search NIH Clinical Center for Panuveitis

Search CenterWatch for Panuveitis

Genetic Tests for Panuveitis

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Anatomical Context for Panuveitis

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32MalaCards
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MalaCards organs/tissues related to Panuveitis:

32
T cells, Bone marrow, Bone, Colon, Liver, Testes

Animal Models for Panuveitis or affiliated genes

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Publications for Panuveitis

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50PubMed
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Articles related to Panuveitis:

(show top 50)    (show all 143)
idTitleAuthorsYear
1
Sarcoid panuveitis associated with etanercept treatment, resolving with adalimumab. (24005973)
2013
2
Successful treatment of corneal wasp sting-induced panuveitis with vitrectomy. (23514564)
2013
3
Long-term control of non-infectious paediatric panuveitis refractory to traditional immunesuppressive therapy, successfully treated with Adalimumab (HumiraTM). (23464830)
2013
4
HLA-DR, DQ Class II DNA Typing in Pediatric Panuveitis and Tubulointerstitial Nephritis and Uveitis (TINU). (24321473)
2013
5
A diagnostic dilemma: infectious versus noninfectious multifocal choroiditis with panuveitis. (23514267)
2013
6
Choroidal assessment in idiopathic panuveitis using optical coherence tomography. (23532454)
2013
7
Treatment of refractory uveitic macular edema with dexamethasone intravitreal implants in a pediatric patient with bilateral granulomatous idiopathic panuveitis: a case report. (24148192)
2013
8
Infectious causes of posterior uveitis and panuveitis in Thailand. (22539102)
2012
9
Levofloxacin-associated panuveitis with chorioretinal lesions. (23044958)
2012
10
High prevalence of anelloviruses in vitreous fluid of children with seasonal hyperacute panuveitis. (22492851)
2012
11
A hairy affair: tarantula setae-induced panuveitis requiring pars plana vitrectomy. (22222718)
2012
12
Herpes simplex encephalitis presenting after steroid treatment of panuveitis. (21770880)
2011
13
Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment trial. (21840602)
2011
14
A single infliximab infusion vs corticosteroids for acute panuveitis attacks in BehAset's disease: a comparative 4-week study. (21097877)
2011
15
Rosai-Dorfman disease simulating nodular scleritis and panuveitis. (21482883)
2011
16
Diagnostic and therapeutic challenges. Acute onset panuveitis. (20142716)
2010
17
A profile and treatment outcome of seasonal hyper-acute panuveitis. (21141325)
2010
18
Diagnostic vitrectomy (25-gauge) in a case with intraocular lymphoma masquerading as bilateral granulomatous panuveitis. (20099241)
2010
19
Current approach in the diagnosis and management of panuveitis. (20029145)
2010
20
Diagnostic and therapeutic challenges: panuveitis and optic neuritis. (19584664)
2009
21
Disseminated cutaneous Mycobacterium chelonae infection with multidrug resistance in a patient with panuveitis. (18021269)
2008
22
Ocular BehAset's disease presenting with retinal tear and panuveitis. (18344955)
2008
23
Unilateral panuveitis secondary to varicella zoster virus. (19198557)
2008
24
Pathological findings of multifocal choroiditis with panuveitis and punctate inner choroidopathy. (18773266)
2008
25
Acute panuveitis with hypopyon in Crohn's disease secondary to medical therapy: a case report. (17610725)
2007
26
Management of bilateral uveitis in a Toxoplasma gondii-seropositive cat with histopathologic evidence of fungal panuveitis. (17565553)
2007
27
Identification of human herpesvirus 6 in a patient with severe unilateral panuveitis. (17923557)
2007
28
Panuveitis and dermal vasculitis following MMR vaccination. (17684869)
2007
29
Leptospirosis and panuveitis in a dog. (16634930)
2006
30
Acute retinal necrosis diagnosed in a child with chronic panuveitis. (16411098)
2006
31
Management of pediatric Vogt-Koyanagi- Harada (VKH)-associated panuveitis. (16597538)
2006
32
Multifocal choroiditis with panuveitis incidence of ocular complications and of loss of visual acuity. (16996607)
2006
33
Bilateral panuveitis in HIV-1-infected patients with CD8 lymphocytosis. (16159723)
2005
34
Longterm follow-up of patients with multifocal choroiditis and panuveitis. (15606476)
2004
35
Retinal detachment in atopic dermatitis can masquerade as acute panuveitis with rapidly progressive cataract. (15579995)
2004
36
Syphilitic panuveitis and asymptomatic neurosyphilis: a marker of HIV infection. (11589818)
2001
37
Differentiation between presumed ocular histoplasmosis syndrome and multifocal choroiditis with panuveitis based on morphology of photographed fundus lesions and fluorescein angiography. (11176981)
2001
38
Bilateral granulomatous panuveitis as initial presentation of diffuse systemic T cell lymphoma. (10516522)
1999
39
Peripheral multifocal chorioretinitis with panuveitis: clinical and immunogenetic characterization in older patients. (9646091)
1998
40
Panuveitis responsive to 2-CdA: an unusual ocular presentation of hairy cell leukemia. (8833410)
1996
41
Panuveal malignant mesenchymoma. (7668945)
1995
42
Bilateral panuveitis in a boy with hypogammaglobulinemia and high IgM. (7970542)
1994
43
Non-caseating conjunctival granulomas in patients with multifocal choroiditis and panuveitis. (8127581)
1994
44
Coxsackievirus B3-associated panuveitis. (8384474)
1993
45
Bilateral panuveitis, sebopsoriasis, and secondary syphilis in a patient with acquired immunodeficiency syndrome. (1463053)
1992
46
Linear streaks in multifocal choroiditis and panuveitis. (1925089)
1991
47
The possible role of herpes viruses in multifocal choroiditis and panuveitis. (2174419)
1990
48
Recurrent bilateral panuveitis and rhegmatogenous retinal detachment in a patient with familial Mediterranean fever. (2248339)
1990
49
Panuveitis with positive serological tests for syphilis and Lyme disease. (2526161)
1989
50
Bilateral cytomegalovirus panuveitis after high-dose corticosteroid therapy. (229732)
1979

Genetic Variations for Panuveitis

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Expression for genes affiliated with Panuveitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Panuveitis

Search GEO for disease gene expression data for Panuveitis.

Pathways for genes affiliated with Panuveitis

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53Reactome, 12EMD Millipore, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Panuveitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response IFN alpha/beta signaling pathway
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10.0IFNA2
2
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10.0IFNA1
39.5IFNA2, IFNA1
49.5IFNA2, IFNA1
5
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
9.5IFNA2, IFNA1
69.5IFNA1, IFNA2
79.3IL10, TNF
8
Hide members
9.3IL10, TNF
99.3IL10, TNF
109.3TNF, IL10
119.3TNF, IL10
12
Hide members
9.3IL10, TNF
139.0IFNA2, IFNA1, IL10
148.9IFNA2, IFNA1, TNF
15
Hide members
8.9IFNA2, IFNA1, TNF
16
Hide members
8.9TNF, IFNA1, IFNA2
17
Hide members
8.9TNF, IFNA1, IFNA2
18
Hide members
8.9TNF, IFNA1, IFNA2
198.4IL10, TNF, IFNA1, IFNA2
20
Hide members
8.4IFNA2, IFNA1, TNF, IL10
21
Hide members
8.4IFNA2, IFNA1, TNF, IL10

Compounds for genes affiliated with Panuveitis

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB, 24HMDB
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Compounds related to Panuveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1tacrolimus44 49 1112.2IFNA1
2pegasys449.9IFNA1, IFNA2
3entecavir449.9IFNA1, IFNA2
4mizoribine449.9IFNA1, IFNA2
5famciclovir44 1110.9IFNA2, IFNA1
6n-phosphonacetyl-l-aspartate449.9IFNA1, IFNA2
7intron a449.9IFNA2, IFNA1
8lomustine44 1110.8IFNA1, IFNA2
9anagrelide44 1110.8IFNA2, IFNA1
10pentostatin44 59 28 1112.8IFNA1, IFNA2
115-deoxy-5-fluorouridine449.8IFNA2, IFNA1
12betaseron449.8IL10, IFNA1
13adefovir449.8IFNA2, IFNA1
14cdp571449.7IL10, TNF
15amantadine44 1110.7IFNA2, IFNA1
16interferon gamma449.7TNF, IL10
17hydroxychloroquine44 1110.7TNF, IFNA2
18didanosine44 1110.6IFNA2, IFNA1
19blys449.6IL10, TNF
20glatiramer acetate44 1110.6IFNA1, IL10
21gabexate mesilate449.6IL10, TNF
22toxin-1449.6IL10, TNF
23mip 1alpha449.6IL10, TNF
24acitretin44 1110.5IFNA2, IFNA1
25dacarbazine44 1110.5IFNA2, IFNA1
26natalizumab44 1110.4TNF, IL10
27ribavirin44 49 1111.4IFNA2, IL10, IFNA1
28busulfan44 1110.4IFNA1, IFNA2
29rantes449.4IFNA1, TNF
30ifn-alpha449.4IL10, IFNA1, IFNA2
31zidovudine44 1110.4IL10, IFNA1, IFNA2
32hydroxyurea44 49 1111.4IFNA1, IL10, IFNA2
33thymidylate449.3IL10, IFNA1, IFNA2
34etanercept44 49 1111.3IL10, TNF, IFNA2
35cyclophosphamide44 49 1111.3IL10, IFNA1, IFNA2
36infliximab44 49 1111.3IFNA2, TNF, IL10
37melphalan44 1110.3IFNA1, IFNA2, TNF
38il-12449.2IFNA1, IL10, TNF
39polyinosinic-polycytidylic acid449.2IFNA1, TNF, IL10
40ccl344 2810.2TNF, IFNA1, IL10
41chloroquine44 2 49 28 1113.2TNF, IL10, IFNA1
42levamisole44 1110.2IFNA1, IFNA2
43imiquimod44 28 59 1111.8IFNA2, IFNA1, IL10, TNF
442,5-oligoadenylate448.8IFNA1, IL10, IFNA2, TNF
45neopterin448.8IFNA2, IFNA1, IL10, TNF
46rituximab44 49 1110.8IFNA1, TNF, IFNA2, IL10
47thalidomide44 49 59 1111.8IFNA2, TNF, IL10, IFNA1
48prednisolone44 28 1110.8TNF, IFNA1, IFNA2, IL10
49thymidine44 249.8IFNA2, TNF, IFNA1, IL10
50vegf448.7IFNA1, TNF, IFNA2, IL10

GO Terms for genes affiliated with Panuveitis

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16Gene Ontology
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Biological processes related to Panuveitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:0328009.6IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:0027409.6IL10, TNF
3negative regulation of growth of symbiont in hostGO:0441309.5TNF, IL10
4negative regulation of interleukin-6 productionGO:0327159.5IL10, TNF
5response to activityGO:0148239.5IL10, TNF
6positive regulation of cytokine secretionGO:0507159.4TNF, IL10
7positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3IL10, TNF
8response to glucocorticoid stimulusGO:0513849.2TNF, IL10
9negative regulation of gene expressionGO:0106299.1TNF, IFNA2
10positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.0UACA, TNF
11inflammatory responseGO:0069548.9IL10, TNF, IFNA2

Molecular functions related to Panuveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.9IL10, TNF, IFNA2

Products for genes affiliated with Panuveitis

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Sources for Panuveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet