MCID: PNV001
MIFTS: 48

Panuveitis malady

Rare diseases, Eye diseases categories
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Summaries for Panuveitis

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NIH Rare Diseases:42 Panuveitis is inflammation of all layers of the uvea of the eye, which includes the iris, ciliary body, and choroid. these make up the middle layer of the eye. the condition can also affect the lens, retina, optic nerve, and vitreous, causing reduced vision or blindness. signs and symptoms may include eye redness and pain; blurring; light sensitivity; decreased vision; and seeing floaters. it can last for a short time or can occur chronically. severe cases may recur many times. in many cases the specific cause is unknown, but in some cases it occurs in association with other eye conditions, or with another condition or infection that also affects other body parts. early treatment is needed and may include eye drops to reduce inflammation and pain, and/or oral medications or injections in severe cases. last updated: 7/22/2014

MalaCards based summary: Panuveitis, also known as inflammation of the whole uveal tract, is related to blau syndrome and uveitis. An important gene associated with Panuveitis is IFNA2 (interferon, alpha 2), and among its related pathways are Interferon Pathway and Regulation of autophagy. The compounds pegasys and entecavir have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related mouse phenotype tumorigenesis.

Aliases & Classifications for Panuveitis

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Panuveitis, Aliases & Descriptions:

Name: Panuveitis 8 42 44 62
Inflammation of the Whole Uveal Tract 42 62
 
Diffuse Uveitis 8 62
Total Uveitis 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:12030
ICD9CM27 360.12
SNOMED-CT57 75614007
MeSH34 D015864
NCIt39 C84989

Related Diseases for Panuveitis

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Diseases related to Panuveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1blau syndrome30.5TNF
2uveitis30.5IFNA2, IL10, TNF
3vasculitis30.4TNF, IFNA2
4hairy cell leukemia30.0IFNA2, IFNA1
5atopic dermatitis29.8TNF, IL10
6multiple sclerosis29.6IFNA1, TNF, IL10
7melanoma29.3IFNA2, IFNA1, TNF, IL10
8choroiditis10.6
9multifocal choroiditis10.6
10lymphomatoid granulomatosis10.5IFNA2
11polyarteritis nodosa10.5IFNA2
12retinitis10.5
13stomatitis10.4IFNA2
14leishmaniasis10.4IL10
15skin disease10.3IFNA1
16punctate inner choroidopathy10.3
17idiopathic panuveitis10.3
18posterior uveitis10.2
19chorioretinitis10.2
20retinal detachment10.2
21tuberculosis10.2
22alcoholic hepatitis10.2TNF, IL10
23acute graft versus host disease10.2TNF, IL10
24arthritis10.2
25scleritis10.2
26syphilis10.2
27cerebral malaria10.1IL10, TNF
28demyelinating disease10.1IL10, TNF
29periodontitis10.1TNF, IL10
30cryoglobulinemic vasculitis10.1IFNA2, IFNA1
31cryoglobulinemia10.1IFNA1, IFNA2
32hepatitis d10.1IFNA2, IFNA1
33graft versus host disease10.1IL10, TNF
34hypothyroidism10.1IFNA1, IFNA2
35sezary's disease10.1IFNA2, IFNA1
36hemorrhagic thrombocythemia10.1IFNA2, IFNA1
37splenomegaly10.1IFNA1, IFNA2
3821-hydroxylase deficiency10.1IFNA2, IFNA1
39eosinophilia10.1IL10, IFNA2
40myelofibrosis10.1IFNA2, IFNA1
41factor vii deficiency10.1IFNA1, IFNA2
42polycythemia vera10.1IFNA1, IFNA2
43thrombocytosis10.1IFNA1, IFNA2
44mycosis fungoides10.1IFNA1, IFNA2
45intraocular lymphoma10.1
46leukemia10.1
47pulmonary tuberculosis10.1
48leptospirosis10.1
49acquired immunodeficiency syndrome10.1
50cerebritis10.1

Graphical network of the top 20 diseases related to Panuveitis:



Diseases related to panuveitis

Symptoms for Panuveitis

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Drugs & Therapeutics for Panuveitis

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Drug clinical trials:

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Search NIH Clinical Center for Panuveitis

Genetic Tests for Panuveitis

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Anatomical Context for Panuveitis

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MalaCards organs/tissues related to Panuveitis:

32
Eye, Retina, T cells, Bone marrow, Bone, Colon, Liver, Testes

Animal Models for Panuveitis or affiliated genes

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MGI Mouse Phenotypes related to Panuveitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5IL10, UACA, TNF

Publications for Panuveitis

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Articles related to Panuveitis:

(show top 50)    (show all 154)
idTitleAuthorsYear
1
Ten-year Perplexing Panuveitis Course in a Case with Juvenile Idiopathic Arthritis and a History of Tuberculosis. (24988273)
2014
2
MULTIFOCAL CHOROIDITIS WITHOUT PANUVEITIS: Clinical Characteristics and Progression. (23670288)
2014
3
Biopsy-proven case of childhood primary angiitis of the central nervous system presenting with bilateral panuveitis and anisocoria. (24962051)
2014
4
Unusual panuveitis in a child: toxocariasis associated with ocular myiasis. (24916981)
2014
5
Sarcoid panuveitis associated with etanercept treatment, resolving with adalimumab. (24005973)
2013
6
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. (23584703)
2013
7
Fulminant Panuveitis following Iris Suture Fixation of Posterior Chamber Intraocular Lens. (23476849)
2013
8
Successful treatment of corneal wasp sting-induced panuveitis with vitrectomy. (23514564)
2013
9
Long-term control of non-infectious paediatric panuveitis refractory to traditional immunesuppressive therapy, successfully treated with Adalimumab (HumiraTM). (23464830)
2013
10
HLA-DR, DQ Class II DNA Typing in Pediatric Panuveitis and Tubulointerstitial Nephritis and Uveitis (TINU). (24321473)
2013
11
Positive immunostaining for feline infectious peritonitis (FIP) in a Sphinx cat with cutaneous lesions and bilateral panuveitis. (23607772)
2013
12
Infectious causes of posterior uveitis and panuveitis in Thailand. (22539102)
2012
13
Levofloxacin-associated panuveitis with chorioretinal lesions. (23044958)
2012
14
Cytomegalovirus panuveitis associated with papillitis in an immunocompetent patient. (22883854)
2012
15
High prevalence of anelloviruses in vitreous fluid of children with seasonal hyperacute panuveitis. (22492851)
2012
16
Sweet's syndrome with panuveitis resembling BehAset's disease. (22399310)
2012
17
Herpes simplex encephalitis presenting after steroid treatment of panuveitis. (21770880)
2011
18
Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment trial. (21840602)
2011
19
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. (21357402)
2011
20
A single infliximab infusion vs corticosteroids for acute panuveitis attacks in BehAset's disease: a comparative 4-week study. (21097877)
2011
21
Melkersson-Rosenthal syndrome in a patient with tubercular panuveitis. (20029155)
2010
22
Very severe HLA B27-associated panuveitis mimicking endophthalmitis: a case series. (20370345)
2010
23
Syphilitic retinitis and panuveitis simulating acute retinal necrosis: case report. (20730290)
2010
24
Syphilitic panuveitis with retinal necrosis in an HIV positive man confirmed by Treponema pallidum PCR. (19766672)
2009
25
Panuveitis associated with granuloma annulare in a child. (19213278)
2009
26
Disseminated cutaneous Mycobacterium chelonae infection with multidrug resistance in a patient with panuveitis. (18021269)
2008
27
Ocular BehAset's disease presenting with retinal tear and panuveitis. (18344955)
2008
28
Molecular diagnosis of a bilateral panuveitis due to Borrelia burgdorferi sensu lato by cerebral spinal fluid analysis. (18503173)
2008
29
Primary intraocular lymphoma mimicking multifocal choroiditis and panuveitis. (17304253)
2007
30
A case of panuveitis with optic disc neovascularization associated with juvenile idiopathic arthritis which progressed during a clinical trial of etanercept]. (18186220)
2007
31
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: comparison of clinical characteristics at presentation. (18046221)
2007
32
Optic neuropathy complicating multifocal choroiditis and panuveitis. (17386295)
2007
33
Peripapillary subretinal fibrosis: a characteristic finding of multifocal choroiditis and panuveitis. (15689822)
2005
34
Demonstration of varicella zoster virus in a case of presumed seasonal hyperacute panuveitis. (16333178)
2005
35
Bilateral panuveitis in HIV-1-infected patients with CD8 lymphocytosis. (16159723)
2005
36
Rifabutin-associated panuveitis with retinal vasculitis in pulmonary tuberculosis. (16321897)
2005
37
Conjunctival lymphoid hyperplasia presenting with bilateral panuveitis. (15767083)
2005
38
Panuveitis associated with multiple sclerosis complicated by cerebral venous thrombosis. (15512986)
2004
39
Ocular filariasis due to Wuchereria bancrofti presenting as panuveitis: a case report. (14533034)
2003
40
Treatment of subfoveal choroidal neovascularization associated with multifocal choroiditis and panuveitis with photodynamic therapy. (12441718)
2002
41
Syphilitic panuveitis and asymptomatic neurosyphilis: a marker of HIV infection. (11589818)
2001
42
Peripheral multifocal chorioretinitis with panuveitis: clinical and immunogenetic characterization in older patients. (9646091)
1998
43
Panuveitis responsive to 2-CdA: an unusual ocular presentation of hairy cell leukemia. (8833410)
1996
44
Bilateral panuveitis in a boy with hypogammaglobulinemia and high IgM. (7970542)
1994
45
Panuveitis and multifocal retinitis in a patient with leucocytoclastic vasculitis. (8318473)
1993
46
Tuberculin-triggered panuveitis in a patient recently treated for active pulmonary tuberculosis. (8250087)
1993
47
Cytomegalovirus panuveitis with infection of corneo-trabecular endothelium in AIDS. (2852787)
1988
48
Arthritis and panuveitis as manifestations of Borrelia burgdorferi infection in a Wisconsin pony. (3793582)
1986
49
Multifocal choroiditis and panuveitis. A syndrome that mimics ocular histoplasmosis. (6508619)
1984
50
Seasonal hyperacute panuveitis of unknown etiology. (6703576)
1984

Variations for Panuveitis

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Expression for genes affiliated with Panuveitis

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Expression patterns in normal tissues for genes affiliated with Panuveitis

Search GEO for disease gene expression data for Panuveitis.

Pathways for genes affiliated with Panuveitis

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Pathways related to Panuveitis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IFNA1, IFNA2
29.5IFNA2, IFNA1
3
Show member pathways
9.5IFNA2, IFNA1
49.5IFNA2, IFNA1
5
Show member pathways
9.5IFNA2, IFNA1
69.5IFNA2, IFNA1
79.3TNF, IL10
89.3TNF, IL10
99.3IL10, TNF
10
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.3IL10, TNF
119.3IL10, TNF
129.3TNF, IL10
13
Show member pathways
IL27-mediated signaling events37
9.3IL10, TNF
14
Show member pathways
9.3IL10, TNF
159.3IL10, TNF
16
Show member pathways
Type III interferon signaling37
9.0IL10, IFNA2, IFNA1
17
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.9IFNA2, IFNA1, TNF
188.9TNF, IFNA1, IFNA2
19
Show member pathways
Immune response CD16 signaling in NK cells60
8.9TNF, IFNA1, IFNA2
20
Show member pathways
8.9TNF, IFNA1, IFNA2
21
Show member pathways
8.9TNF, IFNA1, IFNA2
22
Show member pathways
8.4TNF, IFNA1, IFNA2, IL10
238.4TNF, IFNA1, IFNA2, IL10
24
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.4IL10, IFNA2, IFNA1, TNF
25
Show member pathways
8.4TNF, IFNA1, IFNA2, IL10
268.4IL10, IFNA2, IFNA1, TNF
27
Show member pathways
8.4IL10, IFNA2, IFNA1, TNF

Compounds for genes affiliated with Panuveitis

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Compounds related to Panuveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1pegasys449.9IFNA2, IFNA1
2entecavir449.9IFNA1, IFNA2
3mizoribine449.9IFNA2, IFNA1
4intron a449.9IFNA2, IFNA1
5n-phosphonacetyl-l-aspartate449.8IFNA2, IFNA1
6famciclovir44 1110.8IFNA2, IFNA1
7lomustine44 1110.8IFNA1, IFNA2
8pentostatin44 61 28 1112.8IFNA2, IFNA1
9betaseron449.8IL10, IFNA1
10anagrelide44 1110.8IFNA2, IFNA1
115-deoxy-5-fluorouridine449.8IFNA1, IFNA2
12adefovir449.8IFNA1, IFNA2
13cdp571449.7IL10, TNF
14interferon gamma449.7IL10, TNF
15amantadine44 1110.6IFNA1, IFNA2
16hydroxychloroquine44 1110.6IFNA2, TNF
17blys449.6IL10, TNF
18gabexate mesilate449.6IL10, TNF
19ulinastatin449.5IL10, TNF
20didanosine44 50 1111.5IFNA1, IFNA2
21toxin-1449.5TNF, IL10
22lamivudine44 50 1111.4IL10, IFNA2, IFNA1
23mip 1alpha449.4TNF, IL10
24ribavirin44 50 1111.4IFNA2, IFNA1, IL10
25ifn-alpha449.4IL10, IFNA1, IFNA2
26zidovudine44 50 1111.4IL10, IFNA2, IFNA1
27hydroxyurea44 50 1111.4IL10, IFNA2, IFNA1
28thymidylate449.4IFNA2, IL10, IFNA1
29glatiramer acetate44 1110.3IFNA1, IL10
30etanercept44 50 1111.3TNF, IFNA2, IL10
31cyclophosphamide44 50 1111.3IFNA1, IFNA2, IL10
32infliximab44 50 1111.3IL10, TNF, IFNA2
33melphalan44 50 1111.3TNF, IFNA2, IFNA1
34il-12449.2IL10, TNF, IFNA1
35indoleamine449.2IFNA1, IL10, TNF
36polyinosinic-polycytidylic acid449.2TNF, IFNA1, IL10
37mycophenolate mofetil44 50 1111.2IFNA1, TNF, IL10
38ccl344 2810.2IFNA1, TNF, IL10
39chloroquine44 2 50 28 1113.2TNF, IFNA1, IL10
40tacrolimus44 50 1111.1IFNA1, TNF, IL10
41natalizumab44 1110.0TNF, IL10
42rantes448.8IL10, TNF, IFNA1
43imiquimod44 61 28 1111.8IL10, TNF, IFNA2, IFNA1
442,5-oligoadenylate448.8IL10, IFNA2, TNF, IFNA1
45neopterin448.8TNF, IFNA2, IFNA1, IL10
46rituximab44 50 1110.8TNF, IL10, IFNA1, IFNA2
47thalidomide44 50 61 1111.8TNF, IL10, IFNA2, IFNA1
48prednisolone44 28 1110.8IL10, TNF, IFNA2, IFNA1
49thymidine44 249.8IL10, IFNA1, TNF, IFNA2
50vegf448.7IFNA2, IFNA1, TNF, IL10

GO Terms for genes affiliated with Panuveitis

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Biological processes related to Panuveitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:0328009.6IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:0027409.6IL10, TNF
3negative regulation of growth of symbiont in hostGO:0441309.6IL10, TNF
4negative regulation of interleukin-6 productionGO:0327159.5TNF, IL10
5positive regulation of cytokine secretionGO:0507159.5TNF, IL10
6response to activityGO:0148239.4IL10, TNF
7positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3IL10, TNF
8negative regulation of gene expressionGO:0106299.3IFNA2, TNF
9positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.1UACA, TNF
10inflammatory responseGO:0069549.1IL10, IFNA2, TNF
11intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.0TNF, UACA
12response to glucocorticoidGO:0513849.0IL10, TNF

Molecular functions related to Panuveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.9IL10, IFNA2, TNF

Products for genes affiliated with Panuveitis

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Sources for Panuveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet