MCID: PNV001
MIFTS: 42

Panuveitis malady

Summaries for Panuveitis

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32MalaCards
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MalaCards: Panuveitis, also known as inflammation of the whole uveal tract, is related to uveitis and vasculitis. An important gene associated with Panuveitis is IFNA2 (interferon, alpha 2), and among its related pathways are Immune response IFN alpha/beta signaling pathway and PEDF Induced Signaling. The compounds tacrolimus and pegasys have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and bone.

Aliases & Classifications for Panuveitis

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

panuveitis 8 42 44 60
inflammation of the whole uveal tract 42
diffuse uveitis 8


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Disease Ontology8 DOID:12030
ICD9CM27 360.12
SNOMED-CT56 75614007
MeSH34 D015864
NCIt39 C84989

Related Diseases for Panuveitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Panuveitis:



Diseases related to panuveitis

Clinical Features for Panuveitis

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Drugs & Therapeutics for Panuveitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Panuveitis

Drug clinical trials:

Search ClinicalTrials for Panuveitis

Search NIH Clinical Center for Panuveitis

Search CenterWatch for Panuveitis

Genetic Tests for Panuveitis

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Anatomical Context for Panuveitis

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32MalaCards
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MalaCards organs/tissues related to Panuveitis:

32
T cells, Testes, Bone, Liver, Bone marrow, Colon

Animal Models for Panuveitis or affiliated genes

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Publications for Panuveitis

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50PubMed
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Articles related to Panuveitis:

(show top 50)    (show all 143)
idTitleAuthorsYear
1
MULTIFOCAL CHOROIDITIS WITHOUT PANUVEITIS: Clinical Characteristics and Progression. (23670288)
2014
2
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. (23584703)
2013
3
Positive immunostaining for feline infectious peritonitis (FIP) in a Sphinx cat with cutaneous lesions and bilateral panuveitis. (23607772)
2013
4
Clinical manifestations of cytomegalovirus-associated posterior uveitis and panuveitis in patients without human immunodeficiency virus infection. (23494002)
2013
5
Cytomegalovirus panuveitis associated with papillitis in an immunocompetent patient. (22883854)
2012
6
Sweet's syndrome with panuveitis resembling BehAset's disease. (22399310)
2012
7
The impact of macular edema on visual function in intermediate, posterior, and panuveitis. (22530874)
2012
8
Occult intraocular foreign body masquerading as panuveitis: inductively coupled mass spectrometry and electrophysiologic analysis. (21805383)
2012
9
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. (21357402)
2011
10
Nonsimultaneous bilateral nonrhegmatogenous retinal detachments presenting as a complication of panuveitis in the setting of idiopathic orbital inflammatory syndrome. (22108544)
2011
11
Very severe HLA B27-associated panuveitis mimicking endophthalmitis: a case series. (20370345)
2010
12
Epidemic of unilateral panuveitis in children from Brazilian Amazonia: clinical and etiological aspects in seven patients. (19165423)
2010
13
Panuveitis as a manifestation of ocular syphilis leading to HIV diagnosis. (20606871)
2010
14
Syphilitic panuveitis with retinal necrosis in an HIV positive man confirmed by Treponema pallidum PCR. (19766672)
2009
15
Panuveitis as an initial presentation of extranodal NK/T-cell lymphoma. (19241207)
2009
16
Molecular diagnosis of a bilateral panuveitis due to Borrelia burgdorferi sensu lato by cerebral spinal fluid analysis. (18503173)
2008
17
Diagnostic and therapeutic challenges. Granulomatous panuveitis. (19009682)
2008
18
Primary intraocular lymphoma mimicking multifocal choroiditis and panuveitis. (17304253)
2007
19
Optic neuropathy complicating multifocal choroiditis and panuveitis. (17386295)
2007
20
Chronic panuveitis and scleritis in a patient with cryptogenic organizing pneumonia. (17180535)
2006
21
Photodynamic therapy for choroidal neovascularization in patients with multifocal choroiditis and panuveitis. (16496254)
2006
22
Panuveitis as presenting sign of chickenpox in a young child. (16462882)
2006
23
Peripapillary subretinal fibrosis: a characteristic finding of multifocal choroiditis and panuveitis. (15689822)
2005
24
Conjunctival lymphoid hyperplasia presenting with bilateral panuveitis. (15767083)
2005
25
Herpes zoster panuveitis progression despite acyclovir treatment in a patient following bone marrow transplantation. (16365806)
2005
26
Panuveitis in association with pseudotumor cerebri. (15832615)
2005
27
Panuveitis associated with multiple sclerosis complicated by cerebral venous thrombosis. (15512986)
2004
28
Bartonella henselae infection presenting as a unilateral panuveitis simulating Vogt-Koyanagi-Harada syndrome. (15629311)
2004
29
Acute panuveitis and Takayasu's arteritis. (14500319)
2003
30
Treatment of subfoveal choroidal neovascularization associated with multifocal choroiditis and panuveitis with photodynamic therapy. (12441718)
2002
31
Multifocal choroiditis and panuveitis: immunomodulatory therapy. (11825826)
2002
32
Severe bilateral panuveitis in a patient with asymptomatic Epstein-Barr virus infection. (11827007)
2001
33
Effect of infliximab on threatening panuveitis in BehAset's disease. (11716917)
2001
34
Bilateral panuveitis: a possible association with Kikuchi-Fujimoto disease. (11530065)
2001
35
Panuveitis as a presenting feature of giant cell arteritis. (10744385)
2000
36
Labial adenocarcinoma after treatment with cyclosporin a in a patient with panuveitis. (11004277)
2000
37
Immune recovery vitritis presenting as panuveitis following therapy with protease inhibitors. (11340892)
2000
38
Acute tubulointerstitial nephritis associated with panuveitis. (11096314)
2000
39
Iris angiographic changes in multifocal chorioretinitis with panuveitis. (10541900)
1999
40
Methotrexate treatment for sarcoid-associated panuveitis. (9917790)
1999
41
Panuveitis associated with rifabutin prophylaxis in a pediatric HIV-positive patient. (9559514)
1998
42
Darkfield microscopic (DFM) and serologic evidences for leptospiral infection in panuveitis cases. (9847472)
1998
43
Spontaneous giant retinal pigment epithelial tear associated with panuveitis. (9196939)
1997
44
Panuveitis with papillitis in leptospirosis. (8291582)
1994
45
Panuveitis and multifocal retinitis in a patient with leucocytoclastic vasculitis. (8318473)
1993
46
Cytomegalovirus panuveitis with infection of corneo-trabecular endothelium in AIDS. (2852787)
1988
47
Epstein-Barr viral antibodies in multifocal choroiditis and panuveitis. (3034063)
1987
48
Multifocal choroiditis and panuveitis. A syndrome that mimics ocular histoplasmosis. (6508619)
1984
49
Panuveitis -- presenting symptom of systemic sarcoidosis in a child. (1018199)
1976
50
Herpes simplex panuveitis. A clinical report. (4306494)
1969

Genetic Variations for Panuveitis

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Expression for genes affiliated with Panuveitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Panuveitis

Search GEO for disease gene expression data for Panuveitis.

Pathways for genes affiliated with Panuveitis

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53Reactome, 12EMD Millipore, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Panuveitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response IFN alpha/beta signaling pathway
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10.0IFNA2
2
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10.0IFNA1
39.5IFNA2, IFNA1
49.5IFNA2, IFNA1
5
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
9.5IFNA2, IFNA1
69.5IFNA1, IFNA2
79.3IL10, TNF
8
Hide members
9.3IL10, TNF
99.3IL10, TNF
109.3TNF, IL10
119.3TNF, IL10
12
Hide members
9.3IL10, TNF
139.0IFNA2, IFNA1, IL10
148.9IFNA2, IFNA1, TNF
15
Hide members
8.9IFNA2, IFNA1, TNF
16
Hide members
8.9TNF, IFNA1, IFNA2
17
Hide members
8.9TNF, IFNA1, IFNA2
18
Hide members
8.9TNF, IFNA1, IFNA2
198.4IL10, TNF, IFNA1, IFNA2
20
Hide members
8.4IFNA2, IFNA1, TNF, IL10
21
Hide members
8.4IFNA2, IFNA1, TNF, IL10

Compounds for genes affiliated with Panuveitis

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB, 24HMDB
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Compounds related to Panuveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1tacrolimus44 49 1112.2IFNA1
2pegasys449.9IFNA1, IFNA2
3entecavir449.9IFNA1, IFNA2
4mizoribine449.9IFNA2, IFNA1
5famciclovir44 1110.9IFNA2, IFNA1
6n-phosphonacetyl-l-aspartate449.9IFNA1, IFNA2
7intron a449.9IFNA1, IFNA2
8lomustine44 1110.8IFNA1, IFNA2
9pentostatin44 59 28 1112.8IFNA1, IFNA2
10anagrelide44 1110.8IFNA1, IFNA2
115-deoxy-5-fluorouridine449.8IFNA1, IFNA2
12betaseron449.8IFNA1, IL10
13adefovir449.8IFNA1, IFNA2
14cdp571449.7TNF, IL10
15amantadine44 1110.7IFNA2, IFNA1
16interferon gamma449.7TNF, IL10
17hydroxychloroquine44 1110.7IFNA2, TNF
18didanosine44 1110.6IFNA1, IFNA2
19blys449.6TNF, IL10
20glatiramer acetate44 1110.6IFNA1, IL10
21gabexate mesilate449.6TNF, IL10
22toxin-1449.6IL10, TNF
23mip 1alpha449.6TNF, IL10
24acitretin44 1110.5IFNA2, IFNA1
25dacarbazine44 1110.5IFNA1, IFNA2
26natalizumab44 1110.4IL10, TNF
27ribavirin44 49 1111.4IFNA2, IFNA1, IL10
28busulfan44 1110.4IFNA2, IFNA1
29rantes449.4TNF, IFNA1
30ifn-alpha449.4IL10, IFNA1, IFNA2
31zidovudine44 1110.4IL10, IFNA1, IFNA2
32hydroxyurea44 49 1111.4IFNA2, IFNA1, IL10
33thymidylate449.3IL10, IFNA1, IFNA2
34etanercept44 49 1111.3IFNA2, TNF, IL10
35cyclophosphamide44 49 1111.3IFNA2, IFNA1, IL10
36infliximab44 49 1111.3IL10, TNF, IFNA2
37melphalan44 1110.3IFNA2, IFNA1, TNF
38il-12449.2IL10, TNF, IFNA1
39polyinosinic-polycytidylic acid449.2IL10, TNF, IFNA1
40ccl344 2810.2IL10, TNF, IFNA1
41chloroquine44 2 49 28 1113.2IFNA1, TNF, IL10
42levamisole44 1110.2IFNA1, IFNA2
43imiquimod44 28 59 1111.8IL10, TNF, IFNA1, IFNA2
442,5-oligoadenylate448.8IFNA2, IFNA1, TNF, IL10
45neopterin448.8IL10, TNF, IFNA1, IFNA2
46rituximab44 49 1110.8IFNA2, IFNA1, TNF, IL10
47thalidomide44 49 59 1111.8IL10, TNF, IFNA1, IFNA2
48prednisolone44 28 1110.8IFNA2, IFNA1, TNF, IL10
49thymidine44 249.8IL10, TNF, IFNA1, IFNA2
50vegf448.7IFNA2, IFNA1, TNF, IL10

GO Terms for genes affiliated with Panuveitis

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16Gene Ontology
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Biological processes related to Panuveitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:0328009.6IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:0027409.6IL10, TNF
3negative regulation of growth of symbiont in hostGO:0441309.5TNF, IL10
4negative regulation of interleukin-6 productionGO:0327159.5IL10, TNF
5response to activityGO:0148239.5IL10, TNF
6positive regulation of cytokine secretionGO:0507159.4TNF, IL10
7positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3IL10, TNF
8response to glucocorticoid stimulusGO:0513849.2TNF, IL10
9negative regulation of gene expressionGO:0106299.1TNF, IFNA2
10positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.0UACA, TNF
11inflammatory responseGO:0069548.9IL10, TNF, IFNA2

Molecular functions related to Panuveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.9IL10, TNF, IFNA2

Products for genes affiliated with Panuveitis

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Sources for Panuveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet