MCID: PNV001
MIFTS: 36

Panuveitis malady

Summaries for Panuveitis

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33MalaCards
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MalaCards: Panuveitis, also known as inflammation of the whole uveal tract, is related to uveitis and vasculitis. An important gene associated with Panuveitis is IFNA2 (interferon, alpha 2), and among its related pathways are Immune response IFN alpha/beta signaling pathway and PEDF Induced Signaling. The compounds tacrolimus and pegasys have been mentioned in the context of this disorder.

Aliases & Classifications for Panuveitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 61UMLS, 27ICD9CM, 35MeSH, 40NCIt, 57SNOMED-CT
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Aliases & Descriptions:

panuveitis 8 43 45 61
inflammation of the whole uveal tract 43
diffuse uveitis 8


External Ids:

Disease Ontology8 DOID:12030
ICD9CM27 360.12
SNOMED-CT57 75614007
MeSH35 D015864
NCIt40 C84989

Related Diseases for Panuveitis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Panuveitis:



Diseases related to panuveitis

Clinical Features for Panuveitis

Drugs & Therapeutics for Panuveitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Panuveitis

Drug clinical trials:

Search ClinicalTrials for Panuveitis

Search NIH Clinical Center for Panuveitis

Search CenterWatch for Panuveitis

Genetic Tests for Panuveitis

Anatomical Context for Panuveitis

Animal Models for Panuveitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Panuveitis

Sources:
51PubMed
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Articles related to Panuveitis:

(show top 50)    (show all 142)
idTitleAuthorsYear
1
MULTIFOCAL CHOROIDITIS WITHOUT PANUVEITIS: Clinical Characteristics and Progression. (23670288)
2014
2
Sarcoid panuveitis associated with etanercept treatment, resolving with adalimumab. (24005973)
2013
3
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. (23584703)
2013
4
A diagnostic dilemma: infectious versus noninfectious multifocal choroiditis with panuveitis. (23514267)
2013
5
Clinical manifestations of cytomegalovirus-associated posterior uveitis and panuveitis in patients without human immunodeficiency virus infection. (23494002)
2013
6
Levofloxacin-associated panuveitis with chorioretinal lesions. (23044958)
2012
7
Sweet's syndrome with panuveitis resembling BehAset's disease. (22399310)
2012
8
A hairy affair: tarantula setae-induced panuveitis requiring pars plana vitrectomy. (22222718)
2012
9
Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment trial. (21840602)
2011
10
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. (21357402)
2011
11
Very severe HLA B27-associated panuveitis mimicking endophthalmitis: a case series. (20370345)
2010
12
Diagnostic and therapeutic challenges. Acute onset panuveitis. (20142716)
2010
13
Epidemic of unilateral panuveitis in children from Brazilian Amazonia: clinical and etiological aspects in seven patients. (19165423)
2010
14
Syphilitic panuveitis with retinal necrosis in an HIV positive man confirmed by Treponema pallidum PCR. (19766672)
2009
15
Investigation of multifocal choroiditis with panuveitis by three-dimensional high-penetration optical coherence tomography. (19575418)
2009
16
Ocular BehAset's disease presenting with retinal tear and panuveitis. (18344955)
2008
17
Pathological findings of multifocal choroiditis with panuveitis and punctate inner choroidopathy. (18773266)
2008
18
Optic neuropathy complicating multifocal choroiditis and panuveitis. (17386295)
2007
19
Management of bilateral uveitis in a Toxoplasma gondii-seropositive cat with histopathologic evidence of fungal panuveitis. (17565553)
2007
20
Panuveitis and dermal vasculitis following MMR vaccination. (17684869)
2007
21
Results of intravitreal triamcinolone acetonide (IVTA) injection for the treatment of panuveitis attacks in patients with BehAset disease. (17803439)
2007
22
Acute retinal necrosis diagnosed in a child with chronic panuveitis. (16411098)
2006
23
Photodynamic therapy for choroidal neovascularization in patients with multifocal choroiditis and panuveitis. (16496254)
2006
24
Bilateral panuveitis in HIV-1-infected patients with CD8 lymphocytosis. (16159723)
2005
25
Conjunctival lymphoid hyperplasia presenting with bilateral panuveitis. (15767083)
2005
26
Herpes zoster panuveitis progression despite acyclovir treatment in a patient following bone marrow transplantation. (16365806)
2005
27
Panuveitis in association with pseudotumor cerebri. (15832615)
2005
28
Longterm follow-up of patients with multifocal choroiditis and panuveitis. (15606476)
2004
29
Multifocal choroiditis and panuveitis: immunomodulatory therapy. (11825826)
2002
30
Syphilitic panuveitis and asymptomatic neurosyphilis: a marker of HIV infection. (11589818)
2001
31
Severe bilateral panuveitis in a patient with asymptomatic Epstein-Barr virus infection. (11827007)
2001
32
Effect of infliximab on threatening panuveitis in BehAset's disease. (11716917)
2001
33
Bilateral panuveitis: a possible association with Kikuchi-Fujimoto disease. (11530065)
2001
34
Panuveitis as a presenting feature of giant cell arteritis. (10744385)
2000
35
Immune recovery vitritis presenting as panuveitis following therapy with protease inhibitors. (11340892)
2000
36
Acute tubulointerstitial nephritis associated with panuveitis. (11096314)
2000
37
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: a mini review. (10546386)
1999
38
Iris angiographic changes in multifocal chorioretinitis with panuveitis. (10541900)
1999
39
Peripheral multifocal chorioretinitis with panuveitis: clinical and immunogenetic characterization in older patients. (9646091)
1998
40
Panuveitis associated with rifabutin prophylaxis in a pediatric HIV-positive patient. (9559514)
1998
41
Spontaneous giant retinal pigment epithelial tear associated with panuveitis. (9196939)
1997
42
Panuveitis responsive to 2-CdA: an unusual ocular presentation of hairy cell leukemia. (8833410)
1996
43
Bilateral panuveitis in a boy with hypogammaglobulinemia and high IgM. (7970542)
1994
44
Non-caseating conjunctival granulomas in patients with multifocal choroiditis and panuveitis. (8127581)
1994
45
Panuveitis and multifocal retinitis in a patient with leucocytoclastic vasculitis. (8318473)
1993
46
Coxsackievirus B3-associated panuveitis. (8384474)
1993
47
Bilateral panuveitis, sebopsoriasis, and secondary syphilis in a patient with acquired immunodeficiency syndrome. (1463053)
1992
48
Recurrent bilateral panuveitis and rhegmatogenous retinal detachment in a patient with familial Mediterranean fever. (2248339)
1990
49
Epstein-Barr viral antibodies in multifocal choroiditis and panuveitis. (3034063)
1987
50
Panuveitis -- presenting symptom of systemic sarcoidosis in a child. (1018199)
1976

Genetic Variations for Panuveitis

Expression for genes affiliated with Panuveitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Panuveitis

Search GEO for disease gene expression data for Panuveitis.

Pathways for genes affiliated with Panuveitis

Sources:
54Reactome, 12EMD Millipore, 52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems
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Pathways related to Panuveitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response IFN alpha/beta signaling pathway
Hide members
10.0IFNA2
2
Hide members
10.0IFNA1
39.5IFNA2, IFNA1
49.5IFNA1, IFNA2
5
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
9.5IFNA1, IFNA2
69.5IFNA1, IFNA2
7
Hide members
9.3TNF, IL10
89.3IL10, TNF
99.3IL10, TNF
109.3TNF, IL10
11
Hide members
9.3TNF, IL10
129.3IL10, TNF
139.0IL10, IFNA2, IFNA1
148.9IFNA1, TNF, IFNA2
15
Hide members
8.9IFNA2, TNF, IFNA1
16
Hide members
8.9TNF, IFNA2, IFNA1
17
Hide members
8.9TNF, IFNA1, IFNA2
18
Hide members
8.9TNF, IFNA2, IFNA1
198.4IL10, IFNA2, IFNA1, TNF
20
Hide members
8.4IFNA1, IL10, TNF, IFNA2
21
Hide members
8.4IL10, TNF, IFNA1, IFNA2

Compounds for genes affiliated with Panuveitis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 2BitterDB, 24HMDB
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Compounds related to Panuveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1tacrolimus45 50 1112.2IFNA1
2pegasys459.9IFNA1, IFNA2
3entecavir459.9IFNA1, IFNA2
4mizoribine459.9IFNA1, IFNA2
5famciclovir45 1110.9IFNA2, IFNA1
6n-phosphonacetyl-l-aspartate459.9IFNA1, IFNA2
7intron a459.9IFNA2, IFNA1
8lomustine45 1110.8IFNA1, IFNA2
9anagrelide45 1110.8IFNA2, IFNA1
10pentostatin45 60 29 1112.8IFNA1, IFNA2
115-deoxy-5-fluorouridine459.8IFNA2, IFNA1
12betaseron459.8IL10, IFNA1
13adefovir459.8IFNA2, IFNA1
14cdp571459.7IL10, TNF
15amantadine45 1110.7IFNA2, IFNA1
16interferon gamma459.7TNF, IL10
17hydroxychloroquine45 1110.7TNF, IFNA2
18didanosine45 1110.6IFNA2, IFNA1
19blys459.6IL10, TNF
20glatiramer acetate45 1110.6IFNA1, IL10
21gabexate mesilate459.6IL10, TNF
22toxin-1459.6IL10, TNF
23mip 1alpha459.6IL10, TNF
24acitretin45 1110.5IFNA2, IFNA1
25dacarbazine45 1110.5IFNA2, IFNA1
26natalizumab45 1110.4TNF, IL10
27ribavirin45 50 1111.4IFNA2, IL10, IFNA1
28busulfan45 1110.4IFNA1, IFNA2
29rantes459.4IFNA1, TNF
30ifn-alpha459.4IL10, IFNA1, IFNA2
31zidovudine45 1110.4IL10, IFNA1, IFNA2
32hydroxyurea45 50 1111.4IFNA1, IL10, IFNA2
33thymidylate459.3IL10, IFNA1, IFNA2
34etanercept45 50 1111.3IL10, TNF, IFNA2
35cyclophosphamide45 50 1111.3IL10, IFNA1, IFNA2
36infliximab45 50 1111.3IFNA2, TNF, IL10
37melphalan45 1110.3IFNA1, IFNA2, TNF
38il-12459.2IFNA1, IL10, TNF
39polyinosinic-polycytidylic acid459.2IFNA1, TNF, IL10
40ccl345 2910.2TNF, IFNA1, IL10
41chloroquine45 2 50 29 1113.2TNF, IL10, IFNA1
42levamisole45 1110.2IFNA1, IFNA2
43imiquimod45 29 60 1111.8IFNA2, IFNA1, IL10, TNF
442,5-oligoadenylate458.8IFNA1, IL10, IFNA2, TNF
45neopterin458.8IFNA2, IFNA1, IL10, TNF
46rituximab45 50 1110.8IFNA1, TNF, IFNA2, IL10
47thalidomide45 50 60 1111.8IFNA2, TNF, IL10, IFNA1
48prednisolone45 29 1110.8TNF, IFNA1, IFNA2, IL10
49thymidine45 249.8IFNA2, TNF, IFNA1, IL10
50vegf458.7IFNA1, TNF, IFNA2, IL10

GO Terms for genes affiliated with Panuveitis

Sources:
16Gene Ontology
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Biological processes related to Panuveitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:0328009.6IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:0027409.6IL10, TNF
3negative regulation of growth of symbiont in hostGO:0441309.5TNF, IL10
4negative regulation of interleukin-6 productionGO:0327159.5IL10, TNF
5response to activityGO:0148239.5IL10, TNF
6positive regulation of cytokine secretionGO:0507159.4TNF, IL10
7positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3IL10, TNF
8response to glucocorticoid stimulusGO:0513849.2TNF, IL10
9negative regulation of gene expressionGO:0106299.1TNF, IFNA2
10positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.0UACA, TNF
11inflammatory responseGO:0069548.9IL10, TNF, IFNA2

Molecular functions related to Panuveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.9IL10, TNF, IFNA2

Products for genes affiliated with Panuveitis

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  • Lysates
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Sources for Panuveitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet