MCID: PNV001
MIFTS: 48

Panuveitis malady

Rare diseases, Eye diseases categories
Download this MalaCard

Summaries for Panuveitis

About this section
Sources:
43NIH Rare Diseases, 33MalaCards
See all sources

Fully expand this MalaCard
NIH Rare Diseases:43 Panuveitis is inflammation of all layers of the uvea of the eye, which includes the iris, ciliary body, and choroid. these make up the middle layer of the eye. the condition can also affect the lens, retina, optic nerve, and vitreous, causing reduced vision or blindness. signs and symptoms may include eye redness and pain; blurring; light sensitivity; decreased vision; and seeing floaters. it can last for a short time or can occur chronically. severe cases may recur many times. in many cases the specific cause is unknown, but in some cases it occurs in association with other eye conditions, or with another condition or infection that also affects other body parts. early treatment is needed and may include eye drops to reduce inflammation and pain, and/or oral medications or injections in severe cases. last updated: 7/22/2014

MalaCards: Panuveitis, also known as inflammation of the whole uveal tract, is related to uveitis and vasculitis. An important gene associated with Panuveitis is IFNA2 (interferon, alpha 2), and among its related pathways are Interferon Pathway and Regulation of autophagy. The compounds pegasys and entecavir have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related mouse phenotype tumorigenesis.

Aliases & Classifications for Panuveitis

About this section
Sources:
8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 62UMLS, 35MeSH, 40NCIt, 27ICD9CM, 58SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


Aliases & Descriptions:

panuveitis 8 43 45 62
inflammation of the whole uveal tract 43
diffuse uveitis 8
total uveitis 43


External Ids:

Disease Ontology8 DOID:12030
MeSH35 D015864
SNOMED-CT58 75614007
NCIt40 C84989
ICD9CM27 360.12

Related Diseases for Panuveitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Panuveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.4IL10, IFNA2, TNF
2vasculitis30.3IFNA2, TNF
3blau syndrome30.0TNF
4atopic dermatitis29.8IL10, TNF
5multiple sclerosis29.8IL10, IFNA1, TNF
6choroiditis10.6
7multifocal choroiditis10.6
8retinitis10.4
9punctate inner choroidopathy10.3
10chorioretinitis10.2
11idiopathic panuveitis10.2
12posterior uveitis10.1
13retinal detachment10.1
14scleritis10.1
15syphilis10.1
16lymphomatoid granulomatosis10.1IFNA2
17polyarteritis nodosa10.1IFNA2
18stomatitis10.1IFNA2
19leishmaniasis10.1IL10
20skin disease10.1IFNA1
21leptospirosis10.1
22acquired immunodeficiency syndrome10.1
23intraocular lymphoma10.1
24cerebritis10.1
25adenocarcinoma10.1
26arthritis10.1
27herpes simplex10.1
28histoplasmosis10.1
29hypopyon10.1
30neuritis10.1
31optic neuritis10.1
32sarcoidosis10.1
33tuberculosis10.1
34nephritis10.1
35alcoholic hepatitis10.0IL10, TNF
36acute graft versus host disease10.0TNF, IL10
37cerebral malaria10.0IL10, TNF
38periodontitis10.0TNF, IL10
39cryoglobulinemic vasculitis10.0IFNA2, IFNA1
40cryoglobulinemia10.0IFNA2, IFNA1
41graft versus host disease10.0IL10, TNF
42hepatitis d10.0IFNA2, IFNA1
43hypothyroidism10.0IFNA2, IFNA1
44sezary's disease10.0IFNA1, IFNA2
45hemorrhagic thrombocythemia10.0IFNA1, IFNA2
46splenomegaly10.0IFNA1, IFNA2
47congenital stationary night blindness, type 1f10.0IFNA1, IFNA2
48eosinophilia10.0IL10, IFNA2
49hairy cell leukemia10.0IFNA1, IFNA2
50myelofibrosis10.0IFNA2, IFNA1

Graphical network of the top 20 diseases related to Panuveitis:



Diseases related to panuveitis

Symptoms for Panuveitis

About this section

Drugs & Therapeutics for Panuveitis

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Panuveitis

Search NIH Clinical Center for Panuveitis

Genetic Tests for Panuveitis

About this section

Anatomical Context for Panuveitis

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Panuveitis:

33
Eye, Retina, T cells, Liver, Bone, Testes, Bone marrow, Colon

Animal Models for Panuveitis or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Panuveitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5IL10, UACA, TNF

Publications for Panuveitis

About this section
Sources:
52PubMed
See all sources

Articles related to Panuveitis:

(show top 50)    (show all 140)
idTitleAuthorsYear
1
MULTIFOCAL CHOROIDITIS WITHOUT PANUVEITIS: Clinical Characteristics and Progression. (23670288)
2014
2
Sarcoid panuveitis associated with etanercept treatment, resolving with adalimumab. (24005973)
2013
3
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. (23584703)
2013
4
Fulminant Panuveitis following Iris Suture Fixation of Posterior Chamber Intraocular Lens. (23476849)
2013
5
Successful treatment of corneal wasp sting-induced panuveitis with vitrectomy. (23514564)
2013
6
Long-term control of non-infectious paediatric panuveitis refractory to traditional immunesuppressive therapy, successfully treated with Adalimumab (HumiraTM). (23464830)
2013
7
HLA-DR, DQ Class II DNA Typing in Pediatric Panuveitis and Tubulointerstitial Nephritis and Uveitis (TINU). (24321473)
2013
8
Positive immunostaining for feline infectious peritonitis (FIP) in a Sphinx cat with cutaneous lesions and bilateral panuveitis. (23607772)
2013
9
A diagnostic dilemma: infectious versus noninfectious multifocal choroiditis with panuveitis. (23514267)
2013
10
Infectious causes of posterior uveitis and panuveitis in Thailand. (22539102)
2012
11
Levofloxacin-associated panuveitis with chorioretinal lesions. (23044958)
2012
12
Cytomegalovirus panuveitis associated with papillitis in an immunocompetent patient. (22883854)
2012
13
High prevalence of anelloviruses in vitreous fluid of children with seasonal hyperacute panuveitis. (22492851)
2012
14
Sweet's syndrome with panuveitis resembling BehAset's disease. (22399310)
2012
15
Herpes simplex encephalitis presenting after steroid treatment of panuveitis. (21770880)
2011
16
Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment trial. (21840602)
2011
17
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. (21357402)
2011
18
A single infliximab infusion vs corticosteroids for acute panuveitis attacks in BehAset's disease: a comparative 4-week study. (21097877)
2011
19
Melkersson-Rosenthal syndrome in a patient with tubercular panuveitis. (20029155)
2010
20
Very severe HLA B27-associated panuveitis mimicking endophthalmitis: a case series. (20370345)
2010
21
Syphilitic retinitis and panuveitis simulating acute retinal necrosis: case report. (20730290)
2010
22
Syphilitic panuveitis with retinal necrosis in an HIV positive man confirmed by Treponema pallidum PCR. (19766672)
2009
23
Panuveitis associated with granuloma annulare in a child. (19213278)
2009
24
Diagnostic and therapeutic challenges: panuveitis and optic neuritis. (19584664)
2009
25
Disseminated cutaneous Mycobacterium chelonae infection with multidrug resistance in a patient with panuveitis. (18021269)
2008
26
Ocular BehAset's disease presenting with retinal tear and panuveitis. (18344955)
2008
27
Molecular diagnosis of a bilateral panuveitis due to Borrelia burgdorferi sensu lato by cerebral spinal fluid analysis. (18503173)
2008
28
Primary intraocular lymphoma mimicking multifocal choroiditis and panuveitis. (17304253)
2007
29
A case of panuveitis with optic disc neovascularization associated with juvenile idiopathic arthritis which progressed during a clinical trial of etanercept]. (18186220)
2007
30
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: comparison of clinical characteristics at presentation. (18046221)
2007
31
Optic neuropathy complicating multifocal choroiditis and panuveitis. (17386295)
2007
32
Leptospirosis and panuveitis in a dog. (16634930)
2006
33
Acute retinal necrosis diagnosed in a child with chronic panuveitis. (16411098)
2006
34
Peripapillary subretinal fibrosis: a characteristic finding of multifocal choroiditis and panuveitis. (15689822)
2005
35
Demonstration of varicella zoster virus in a case of presumed seasonal hyperacute panuveitis. (16333178)
2005
36
Bilateral panuveitis in HIV-1-infected patients with CD8 lymphocytosis. (16159723)
2005
37
Rifabutin-associated panuveitis with retinal vasculitis in pulmonary tuberculosis. (16321897)
2005
38
Conjunctival lymphoid hyperplasia presenting with bilateral panuveitis. (15767083)
2005
39
Panuveitis associated with multiple sclerosis complicated by cerebral venous thrombosis. (15512986)
2004
40
Ocular filariasis due to Wuchereria bancrofti presenting as panuveitis: a case report. (14533034)
2003
41
Treatment of subfoveal choroidal neovascularization associated with multifocal choroiditis and panuveitis with photodynamic therapy. (12441718)
2002
42
Syphilitic panuveitis and asymptomatic neurosyphilis: a marker of HIV infection. (11589818)
2001
43
Peripheral multifocal chorioretinitis with panuveitis: clinical and immunogenetic characterization in older patients. (9646091)
1998
44
Bilateral panuveitis in a boy with hypogammaglobulinemia and high IgM. (7970542)
1994
45
Panuveitis and multifocal retinitis in a patient with leucocytoclastic vasculitis. (8318473)
1993
46
The possible role of herpes viruses in multifocal choroiditis and panuveitis. (2174419)
1990
47
Cytomegalovirus panuveitis with infection of corneo-trabecular endothelium in AIDS. (2852787)
1988
48
Arthritis and panuveitis as manifestations of Borrelia burgdorferi infection in a Wisconsin pony. (3793582)
1986
49
Multifocal choroiditis and panuveitis. A syndrome that mimics ocular histoplasmosis. (6508619)
1984
50
Seasonal hyperacute panuveitis of unknown etiology. (6703576)
1984

Variations for Panuveitis

About this section

Expression for genes affiliated with Panuveitis

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Panuveitis

Search GEO for disease gene expression data for Panuveitis.

Pathways for genes affiliated with Panuveitis

About this section
Sources:
50PathCards, 53QIAGEN, 30KEGG, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 54R&D Systems
See all sources

Pathways related to Panuveitis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IFNA1, IFNA2
29.5IFNA2, IFNA1
3
Show member pathways
9.5IFNA2, IFNA1
49.5IFNA2, IFNA1
5
Show member pathways
9.5IFNA2, IFNA1
69.5IFNA2, IFNA1
79.3TNF, IL10
89.3TNF, IL10
99.3IL10, TNF
10
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.3IL10, TNF
119.3IL10, TNF
129.3TNF, IL10
13
Show member pathways
IL27-mediated signaling events38
9.3IL10, TNF
14
Show member pathways
9.3IL10, TNF
159.3IL10, TNF
16
Show member pathways
Type III interferon signaling38
9.0IL10, IFNA2, IFNA1
17
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.9IFNA2, IFNA1, TNF
188.9TNF, IFNA1, IFNA2
19
Show member pathways
Immune response CD16 signaling in NK cells60
8.9TNF, IFNA1, IFNA2
20
Show member pathways
8.9TNF, IFNA1, IFNA2
21
Show member pathways
8.9TNF, IFNA1, IFNA2
22
Show member pathways
8.4TNF, IFNA1, IFNA2, IL10
238.4TNF, IFNA1, IFNA2, IL10
24
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.4IL10, IFNA2, IFNA1, TNF
25
Show member pathways
8.4TNF, IFNA1, IFNA2, IL10
268.4IL10, IFNA2, IFNA1, TNF
27
Show member pathways
8.4IL10, IFNA2, IFNA1, TNF

Compounds for genes affiliated with Panuveitis

About this section
Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 3BitterDB, 24HMDB
See all sources

Compounds related to Panuveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1pegasys459.9IFNA2, IFNA1
2entecavir459.9IFNA1, IFNA2
3mizoribine459.9IFNA2, IFNA1
4intron a459.9IFNA2, IFNA1
5n-phosphonacetyl-l-aspartate459.8IFNA2, IFNA1
6famciclovir45 1110.8IFNA2, IFNA1
7lomustine45 1110.8IFNA1, IFNA2
8pentostatin45 61 29 1112.8IFNA2, IFNA1
9betaseron459.8IL10, IFNA1
10anagrelide45 1110.8IFNA2, IFNA1
115-deoxy-5-fluorouridine459.8IFNA1, IFNA2
12adefovir459.8IFNA1, IFNA2
13cdp571459.7IL10, TNF
14interferon gamma459.7IL10, TNF
15amantadine45 1110.6IFNA1, IFNA2
16hydroxychloroquine45 1110.6IFNA2, TNF
17blys459.6IL10, TNF
18gabexate mesilate459.6IL10, TNF
19ulinastatin459.5IL10, TNF
20didanosine45 51 1111.5IFNA1, IFNA2
21toxin-1459.5TNF, IL10
22lamivudine45 51 1111.4IL10, IFNA2, IFNA1
23mip 1alpha459.4TNF, IL10
24ribavirin45 51 1111.4IFNA2, IFNA1, IL10
25ifn-alpha459.4IL10, IFNA1, IFNA2
26zidovudine45 51 1111.4IL10, IFNA2, IFNA1
27hydroxyurea45 51 1111.4IL10, IFNA2, IFNA1
28thymidylate459.4IFNA2, IL10, IFNA1
29glatiramer acetate45 1110.3IFNA1, IL10
30etanercept45 51 1111.3TNF, IFNA2, IL10
31cyclophosphamide45 51 1111.3IFNA1, IFNA2, IL10
32infliximab45 51 1111.3IL10, TNF, IFNA2
33melphalan45 51 1111.3TNF, IFNA2, IFNA1
34il-12459.2IL10, TNF, IFNA1
35indoleamine459.2IFNA1, IL10, TNF
36polyinosinic-polycytidylic acid459.2TNF, IFNA1, IL10
37mycophenolate mofetil45 51 1111.2IFNA1, TNF, IL10
38ccl345 2910.2IFNA1, TNF, IL10
39chloroquine45 3 51 29 1113.2TNF, IFNA1, IL10
40tacrolimus45 51 1111.1IFNA1, TNF, IL10
41natalizumab45 1110.0TNF, IL10
42rantes458.8IL10, TNF, IFNA1
43imiquimod45 61 29 1111.8IL10, TNF, IFNA2, IFNA1
442,5-oligoadenylate458.8IL10, IFNA2, TNF, IFNA1
45neopterin458.8TNF, IFNA2, IFNA1, IL10
46rituximab45 51 1110.8TNF, IL10, IFNA1, IFNA2
47thalidomide45 51 61 1111.8TNF, IL10, IFNA2, IFNA1
48prednisolone45 29 1110.8IL10, TNF, IFNA2, IFNA1
49thymidine45 249.8IL10, IFNA1, TNF, IFNA2
50vegf458.7IFNA2, IFNA1, TNF, IL10

GO Terms for genes affiliated with Panuveitis

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Panuveitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:0328009.6IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:0027409.6IL10, TNF
3negative regulation of growth of symbiont in hostGO:0441309.6IL10, TNF
4negative regulation of interleukin-6 productionGO:0327159.5TNF, IL10
5positive regulation of cytokine secretionGO:0507159.5TNF, IL10
6response to activityGO:0148239.4IL10, TNF
7positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3IL10, TNF
8negative regulation of gene expressionGO:0106299.3IFNA2, TNF
9positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.1UACA, TNF
10inflammatory responseGO:0069549.1IL10, IFNA2, TNF
11intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.0TNF, UACA
12response to glucocorticoidGO:0513849.0IL10, TNF

Molecular functions related to Panuveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.9IL10, IFNA2, TNF

Products for genes affiliated with Panuveitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Panuveitis

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet