MCID: PNV001
MIFTS: 50

Panuveitis malady

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Panuveitis

Aliases & Descriptions for Panuveitis:

Name: Panuveitis 12 50 52 42 14 69
Diffuse Uveitis 12 50
Inflammation of the Whole Uveal Tract 50
Total Uveitis 50

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:12030
ICD10 33 H44.11
ICD9CM 35 360.12
MeSH 42 D015864
NCIt 47 C84989
SNOMED-CT 64 75614007
UMLS 69 C0030343

Summaries for Panuveitis

NIH Rare Diseases : 50 panuveitis is inflammation of all layers of the uvea of the eye, which includes the iris, ciliary body, and choroid. these make up the middle layer of the eye. the condition can also affect the lens, retina, optic nerve, and vitreous, causing reduced vision or blindness. signs and symptoms may include eye redness and pain; blurring; light sensitivity; decreased vision; and seeing floaters. it can last for a short time or can occur chronically. severe cases may recur many times. in many cases the specific cause is unknown, but in some cases it occurs in association with other eye conditions, or with another condition or infection that also affects other body parts. early treatment is needed and may include eye drops to reduce inflammation and pain; and/or oral medications or injections in severe cases. last updated: 11/17/2016

MalaCards based summary : Panuveitis, also known as diffuse uveitis, is related to uveitis and t-cell prolymphocytic leukemia. An important gene associated with Panuveitis is UACA (Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and endocrine/exocrine gland

Related Diseases for Panuveitis

Diseases in the Panuveitis family:

Infectious Panuveitis

Diseases related to Panuveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 270)
id Related Disease Score Top Affiliating Genes
1 uveitis 30.0 CD4 CD40LG TNF
2 t-cell prolymphocytic leukemia 29.6 HLA-DQB1 TNF
3 syphilis 29.5 CD4 CD40LG
4 pulmonary tuberculosis 29.5 CD40LG IL10 TNF
5 tuberculosis 29.3 CD4 CD40LG IL10 IL17A TNF
6 myiasis 29.3 CD40LG IL10 TNF
7 chorioretinitis 29.2 CD40LG HLA-DRB1 IL10 TNF TNFRSF1B
8 idiopathic panuveitis 11.9
9 infectious panuveitis 11.8
10 vogt-koyanagi-harada disease 11.2
11 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
12 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 TNF
13 lagophthalmos 10.3 IL10 TNF
14 nguyen syndrome 10.3 IL10 IL17A
15 multiple vertebral anomalies unusual facies 10.3 IL10 TNF
16 conidiobolomycosis 10.3 IL10 TNF
17 apple allergy 10.3 HLA-DQB1 HLA-DRB1
18 hemoglobin d disease 10.3 HLA-DQB1 HLA-DRB1
19 choroiditis 10.3
20 lin-gettig syndrome 10.2 HLA-DQB1 HLA-DRB1
21 endosalpingiosis 10.2 IL10 TNF
22 midline interhemispheric variant of holoprosencephaly 10.2 HLA-DQB1 HLA-DRB1
23 parkinson disease 11 10.2 IL10 IL17A TNF
24 trichomalacia 10.2 IL10 IL17A TNF
25 gastric dilatation 10.2 IL10 IL17A TNF
26 multifocal choroiditis 10.2
27 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IL10 TNF
28 burns 10.2 IL10 IL17A TNF
29 renal agenesis meningomyelocele mullerian defect 10.2 HLA-DQB1 HLA-DRB1
30 bilateral parasagittal parieto-occipital polymicrogyria 10.2 HLA-DQB1 HLA-DRB1 TNF
31 vulvar nodular hidradenoma 10.2 IL10 IL17A TNF
32 parasitic protozoa infectious disease 10.2 IL10 IL17A TNF
33 autosomal dominant intermediate charcot-marie-tooth 10.2 HLA-DQB1 HLA-DRB1 TNF
34 distal trisomy 14q 10.2 HLA-DQB1 HLA-DRB1 TNF
35 lyme disease - neurological complications 10.2 HLA-DQB1 HLA-DRB1
36 clostridium difficile colitis 10.2 HLA-DQB1 HLA-DRB1 TNF
37 optic nerve hypoplasia 10.2 IL10 IL17A TNF
38 peripheral artery disease 10.2 HLA-DRB1 IL10 TNF
39 cardiac sarcoidosis 10.2 TNF TNFRSF1B
40 spontaneous ocular nystagmus 10.2 IL10 IL17A TNF
41 neonatal jaundice 10.2 IL10 IL17A TNF
42 bare lymphocyte syndrome, type i 10.2 IL10 IL17A TNF
43 myofibroma 10.2 HLA-DQB1 HLA-DRB1 IL10
44 neonatal antiphospholipid syndrome 10.2 HLA-DQB1 HLA-DRB1 IL17A
45 periarthritis 10.2 HLA-DRB1 IL10 TNF
46 childhood infratentorial neoplasm 10.2 TNF TNFRSF1B
47 intratubular embryonal carcinoma 10.2 IL10 IL17A TNF
48 night blindness 10.2 HLA-DQB1 HLA-DRB1 MRAP
49 sacral nerve root cysts 10.2 HLA-B HLA-DRB1
50 nemaline myopathy 1, autosomal dominant or recessive 10.2 TNF TNFRSF1B

Graphical network of the top 20 diseases related to Panuveitis:



Diseases related to Panuveitis

Symptoms & Phenotypes for Panuveitis

GenomeRNAi Phenotypes related to Panuveitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 IL10 IL17A TNF TNFRSF1B CD40LG HLA-DQB1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 IL17A TNF TNFRSF1B CD40LG HLA-DQB1 IL10

MGI Mouse Phenotypes related to Panuveitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 CD4 CD40LG HLA-DQB1 IL10 IL17A TNF
2 digestive/alimentary MP:0005381 9.73 CD4 HLA-DQB1 IL10 IL17A TNF TNFRSF1B
3 hematopoietic system MP:0005397 9.56 CD4 CD40LG HLA-DQB1 IL10 IL17A TNF
4 respiratory system MP:0005388 9.1 TNFRSF1B UACA HLA-DQB1 IL10 IL17A TNF

Drugs & Therapeutics for Panuveitis

Drugs for Panuveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 164)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
3
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 67-73-2 6215
4
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3 79217-60-0, 59865-13-3 5284373 6435893
5
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
7
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
8
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
9
Chlorambucil Approved Phase 4 305-03-3 2708
10
Cyclophosphamide Approved, Investigational Phase 4,Phase 2 50-18-0, 6055-19-2 2907
11
Daclizumab Approved, Investigational Phase 4,Phase 2 152923-56-3
12
Infliximab Approved Phase 4,Phase 3,Phase 1,Phase 2 170277-31-3
13
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3 128794-94-5 5281078
14
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
15
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
16
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
17
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
18
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
19
Timolol Approved Phase 4 26839-75-8 33624 5478
20
Travoprost Approved Phase 4 157283-68-6 5282226
21
Bevacizumab Approved, Investigational Phase 4,Phase 3 216974-75-3
22
Certolizumab pegol Approved Phase 4 428863-50-7
23
Maleic acid Experimental Phase 4 110-16-7 444266
24 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
25 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
26 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
27 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
29 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
30 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
31 Hormones Phase 4,Phase 3,Phase 2,Phase 1
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
33 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1
34 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2,Phase 1
35 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1
38 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2,Phase 1
39 Prednisolone phosphate Phase 4,Phase 3,Phase 2,Phase 1
40 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
42 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
43 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
45 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1
46 Dexamethasone 21-phosphate Phase 4,Phase 3,Phase 2,Phase 1
47 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
48 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
49
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1
50 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 140)
id Name Status NCT ID Phase
1 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4
2 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4
3 Multicenter Uveitis Steroid Treatment (MUST) Trial Completed NCT00132691 Phase 4
4 Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAG Completed NCT01978015 Phase 4
5 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4
6 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
7 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4
8 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4
9 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Recruiting NCT03020992 Phase 4
10 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Not yet recruiting NCT02769702 Phase 4
11 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Not yet recruiting NCT03066869 Phase 4
12 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Not yet recruiting NCT03133767 Phase 4
13 Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Unknown status NCT00167583 Phase 3
14 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3
15 A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis Completed NCT00404742 Phase 3
16 A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis Completed NCT00404612 Phase 3
17 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Severe Uveitis Completed NCT00407056 Phase 3
18 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00406887 Phase 3
19 Phase III Study in Refractory Behcet's Disease Completed NCT00995709 Phase 3
20 Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis Completed NCT01124838 Phase 3
21 A Multi-center Study to Assess the Efficacy and Safety of LX211 in Active Non-infectious Anterior Uveitis Completed NCT00404885 Phase 3
22 Efficacy and Safety of Adalimumab in Patients With Active Uveitis Completed NCT01138657 Phase 3
23 Efficacy and Safety of Voclosporin to Treat Active Noninfectious Uveitis Completed NCT01243983 Phase 3
24 Safety and Efficacy of Fluocinolone Acetonide Intravitreal Implants Completed NCT00407082 Phase 2, Phase 3
25 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3
26 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3
27 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate or Posterior Uveitis Completed NCT00333814 Phase 2, Phase 3
28 Myfortic for the Treatment of Non-infectious Intermediate Uveitis Completed NCT01092533 Phase 3
29 Clinical Study of TA-650 in Patients With Behcet's Disease (BD) With Special Lesions Completed NCT01532570 Phase 3
30 A Study of Adalimumab in Japanese Subjects With Intestinal Behçet's Disease Completed NCT01243671 Phase 3
31 Efficacy of Humira in Behcet Patients With Arthritis Completed NCT01497717 Phase 3
32 Intravitreal Bevacizumab for Inflammatory Neovascular Membranes Completed NCT00407121 Phase 3
33 Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis Completed NCT00344253 Phase 3
34 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Recruiting NCT03097315 Phase 3
35 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Recruiting NCT02595398 Phase 3
36 A Phase 3 Study to Evaluate ADX-102 Ophthalmic Solution in Subjects With Non-infectious Anterior-uveitis. Recruiting NCT03131154 Phase 3
37 Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis Recruiting NCT02517619 Phase 3
38 A Study to Evaluate Efficacy and Safety of Infliximab in Participant With Moderate-to-Severe Refractory Intestinal Behcet's Disease Recruiting NCT02505568 Phase 3
39 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Active, not recruiting NCT01148225 Phase 3
40 A Controlled, Multi-center Study of the Utilization and Safety of the MK II Inserter and the Safety of the FAI Insert in Subjects With Non-infectious Uveitis Affecting the Posterior Segment of the Eye Active, not recruiting NCT02748512 Phase 3
41 Safety and Efficacy Study of a Fluocinolone Acetonide Intravitreal (FAI) Insert in Subjects With Chronic Non-infectious Posterior Uveitis Active, not recruiting NCT02746991 Phase 3
42 Safety and Efficacy of an Injectable Fluocinolone Acetonide Intravitreal Insert Active, not recruiting NCT01694186 Phase 3
43 A Phase 3 Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Active Behcet's Disease Active, not recruiting NCT02307513 Phase 3
44 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01032915 Phase 3
45 38 Week Extension Study to CAIN457C2303 Terminated NCT01093846 Phase 3
46 Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis Terminated NCT01095250 Phase 3
47 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01090310 Phase 3
48 Safety and Efficacy Study of Gevokizumab to Treat Active Non-infectious Uveitis Terminated NCT01684345 Phase 3
49 Safety and Efficacy Study of Gevokizumab to Treat Non-infectious Uveitis Controlled With Systemic Treatment Terminated NCT01747538 Phase 3
50 Extension Study to Assess Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis Terminated NCT01103024 Phase 3

Search NIH Clinical Center for Panuveitis

Cochrane evidence based reviews: panuveitis

Genetic Tests for Panuveitis

Anatomical Context for Panuveitis

MalaCards organs/tissues related to Panuveitis:

39
Eye, Retina, T Cells, Testes, Liver, Colon, Bone Marrow

Publications for Panuveitis

Articles related to Panuveitis:

(show top 50) (show all 191)
id Title Authors Year
1
Canine panuveitis: a retrospective evaluation of 55 cases (2000-2015). ( 27734587 )
2016
2
Long-term Management of Panuveitis and Iris Heterochromia in an Ebola Survivor. ( 27594198 )
2016
3
Injectable Fluocinolone Acetonide Long-Acting Implant for Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Two-Year Results. ( 27421623 )
2016
4
TARANTULA HAIR ASSOCIATED PANUVEITIS TREATED WITH SUSTAINED-RELEASE INTRAVITREAL DEXAMETHASONE IMPLANT. ( 27472515 )
2016
5
Dengue Fever-Associated Maculopathy and Panuveitis in Australia. ( 28078150 )
2016
6
Choroidal Vascularity Index (CVI)--A Novel Optical Coherence Tomography Parameter for Monitoring Patients with Panuveitis? ( 26751702 )
2016
7
Human Immunodeficiency Virus-Infected Man With Acute Visual Impairment and Panuveitis Due to Syphilis Despite Initially Negative Rapid Plasma Reagin. ( 27893602 )
2016
8
Risk of Ocular Complications in Patients with Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis. ( 26712559 )
2016
9
Topical difluprednate for treatment of serous retinal detachment and panuveitis associated with Vogt-Koyanagi-Harada disease. ( 27582676 )
2016
10
Idiopathic Orbital Inflammation Presenting with Bilateral Panuveitis. ( 27112170 )
2016
11
Multifocal choroiditis with panuveitis in an 8-year-old boy with long-standing idiopathic acute anterior uveitis. ( 26951535 )
2016
12
GRAFT-VERSUS-HOST DISEASE PANUVEITIS AND BILATERAL SEROUS DETACHMENTS: MULTIMODAL IMAGING ANALYSIS. ( 27571426 )
2016
13
A Hemophagocytic Lymphohistiocytosis Patient that Presented With Unilateral Panuveitis. ( 26731243 )
2016
14
A Case of Severe Panuveitis Associated with Psoriasis Vulgaris Successfully Treated with Infliximab. ( 27239187 )
2016
15
Direct and indirect resource use, healthcare costs and work force absence in patients with non-infectious intermediate, posterior or panuveitis. ( 26932535 )
2016
16
Differentiation of severe bilateral panuveitis following phacoemulsification: a case report. ( 27277218 )
2016
17
Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears. ( 27612415 )
2016
18
A 22 year old woman with bilateral panuveitis and parotid swelling. ( 26265714 )
2015
19
Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial. ( 26386159 )
2015
20
Panuveitis With Exudative Retinal Detachments After Vaccination Against Human Papilloma Virus. ( 26469238 )
2015
21
Combination immunotherapy in the treatment of chronic bilateral panuveitis and uveitic glaucoma during acute dengue fever infection in the Caribbean. ( 26229512 )
2015
22
Erratum to: Successful treatment with adalimumab for severe multifocal choroiditis and panuveitis in presumed (early-onset) ocular sarcoidosis. ( 26500039 )
2015
23
Severe bilateral panuveitis during melanoma treatment by Dabrafenib and Trametinib. ( 26078801 )
2015
24
Quality of Life and Risks Associated with Systemic Anti-inflammatory Therapy versus Fluocinolone Acetonide Intraocular Implant for Intermediate Uveitis, Posterior Uveitis, or Panuveitis: Fifty-four-Month Results of the Multicenter Uveitis Steroid Treatment Trial and Follow-up Study. ( 26298718 )
2015
25
Positive Immunolabelling for Feline Infectious Peritonitis in an African Lion (Panthera leo) with Bilateral Panuveitis. ( 25678422 )
2015
26
Heterogeneity of primary outcome measures used in clinical trials of treatments for intermediate, posterior, and panuveitis. ( 26286265 )
2015
27
Specific association of IL17A genetic variants with panuveitis. ( 25595174 )
2015
28
SEVERE PANUVEITIS, RETINAL VASCULITIS, AND OPTIC DISK GRANULOMA SECONDARY TO SARCOIDOSIS. ( 26650564 )
2015
29
Intermediate uveitis, posterior uveitis, and panuveitis in the Mid-Atlantic USA. ( 26345421 )
2015
30
Two cases of panuveitis with orbital inflammatory syndrome after influenza vaccination. ( 26455985 )
2015
31
MULTIFOCAL CHOROIDITIS AND PANUVEITIS PRESENTING WITH PROGRESSIVE EQUATORIAL LINEAR STREAKS: EVOLUTION OF SCHLAEGEL LINES DOCUMENTED WITH MULTIMODAL IMAGING. ( 25790317 )
2015
32
Benefits of Systemic Anti-inflammatory Therapy versus Fluocinolone Acetonide Intraocular Implant for Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Fifty-four-Month Results of the Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study. ( 26298715 )
2015
33
Successful treatment with adalimumab for severe multifocal choroiditis and panuveitis in presumed (early-onset) ocular sarcoidosis. ( 26449230 )
2015
34
Panuveitis caused by Borrelia burgdorferi sensu lato infection. ( 25741803 )
2015
35
Trends in Patterns of Posterior Uveitis and Panuveitis in a Tertiary Institution in Singapore. ( 25140702 )
2014
36
MULTIFOCAL CHOROIDITIS WITHOUT PANUVEITIS: Clinical Characteristics and Progression. ( 23670288 )
2014
37
A case of panuveitis with hypopyon due to presumed ocular leishmaniasis in a HIV patient. ( 26530344 )
2014
38
Acute bilateral glaucoma and panuveitis as a side effect of topiramate for weight loss treatment. ( 24744070 )
2014
39
Ten-year Perplexing Panuveitis Course in a Case with Juvenile Idiopathic Arthritis and a History of Tuberculosis. ( 24988273 )
2014
40
Biopsy-proven case of childhood primary angiitis of the central nervous system presenting with bilateral panuveitis and anisocoria. ( 24962051 )
2014
41
Rhegmatogenous Retinal Detachment in Patients with Acute Syphilitic Panuveitis. ( 24960278 )
2014
42
Bilateral panuveitis associated with Whipple disease - case report. ( 27625936 )
2014
43
Aids-related primary CNS non-Hodgkin's lymphoma in a patient with previous Epstein-Barr virus panuveitis. A clinico-pathological report. ( 25443210 )
2014
44
Delayed onset panuveitis following intravitreal aflibercept injection. ( 24920511 )
2014
45
Cost-effectiveness of fluocinolone acetonide implant versus systemic therapy for noninfectious intermediate, posterior, and panuveitis. ( 24908205 )
2014
46
Unusual panuveitis in a child: toxocariasis associated with ocular myiasis. ( 24916981 )
2014
47
A case of bilateral human herpes virus 6 panuveitis with genomic viral DNA integration. ( 24995045 )
2014
48
Bilateral panuveitis in a patient on vemurafenib BRAF inhibitor therapy for stage IV melanoma. ( 24474376 )
2014
49
Idiopathic orbital inflammation associated with panuveitis in an adult and a review of the literature. ( 24404668 )
2013
50
Positive immunostaining for feline infectious peritonitis (FIP) in a Sphinx cat with cutaneous lesions and bilateral panuveitis. ( 23607772 )
2013

Variations for Panuveitis

Expression for Panuveitis

Search GEO for disease gene expression data for Panuveitis.

Pathways for Panuveitis

Pathways related to Panuveitis according to GeneCards Suite gene sharing:

(show all 38)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 CD4 CD40LG HLA-B HLA-DQB1 HLA-DRB1 IL10
2
Show member pathways
13.3 CD4 CD40LG IL10 IL17A TNF TNFRSF1B
3
Show member pathways
13.19 CD4 CD40LG IL10 IL17A TNF TNFRSF1B
4
Show member pathways
13.02 CD4 CD40LG HLA-B HLA-DQB1 HLA-DRB1 IL10
5
Show member pathways
12.56 CD4 CD40LG TNF TNFRSF1B
6
Show member pathways
12.49 CD4 IL10 IL17A TNF
7 12.43 CD40LG IL10 IL17A TNF TNFRSF1B
8
Show member pathways
12.38 CD4 HLA-DQB1 HLA-DRB1 IL10 IL17A TNF
9 12.35 HLA-B HLA-DQB1 HLA-DRB1 TNF
10
Show member pathways
12.3 CD4 CD40LG HLA-DQB1 HLA-DRB1
11
Show member pathways
12.29 CD4 CD40LG IL10 IL17A TNF
12 12.21 HLA-B HLA-DQB1 HLA-DRB1 IL10
13 12.12 HLA-DQB1 HLA-DRB1 IL10 TNF
14
Show member pathways
12.07 CD40LG HLA-DQB1 HLA-DRB1 IL10 TNF
15
Show member pathways
12.06 HLA-B IL10 IL17A TNF
16
Show member pathways
12.06 CD4 CD40LG HLA-DQB1 HLA-DRB1 IL10 TNF
17 12.03 HLA-B HLA-DQB1 HLA-DRB1
18
Show member pathways
11.97 CD4 CD40LG HLA-B HLA-DQB1 HLA-DRB1 IL10
19 11.91 CD4 IL10 TNF
20 11.88 IL10 IL17A TNF TNFRSF1B
21 11.88 CD4 CD40LG HLA-B HLA-DQB1 HLA-DRB1
22
Show member pathways
11.87 CD4 HLA-DQB1 HLA-DRB1
23
Show member pathways
11.84 CD4 IL10 IL17A TNF
24 11.78 CD4 HLA-DQB1 HLA-DRB1 TNF
25
Show member pathways
11.75 CD40LG TNF TNFRSF1B
26 11.71 HLA-DQB1 HLA-DRB1 IL17A TNF
27 11.7 CD4 IL10 TNF
28
Show member pathways
11.67 CD40LG TNF TNFRSF1B
29 11.66 CD4 HLA-DQB1 HLA-DRB1
30 11.64 CD40LG IL10 TNF
31 11.64 CD4 IL10 IL17A TNF
32 11.54 HLA-DQB1 HLA-DRB1 IL10
33 11.5 CD4 CD40LG IL10
34 11.45 IL10 TNF TNFRSF1B
35 11.44 CD40LG IL10 TNF
36
Show member pathways
11.34 IL10 TNF TNFRSF1B
37 11.12 CD40LG IL10 IL17A TNF
38 10.93 CD4 HLA-DRB1 IL10 TNF

GO Terms for Panuveitis

Cellular components related to Panuveitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 CD4 CD40LG HLA-B HLA-DRB1 TNF
2 ER to Golgi transport vesicle membrane GO:0012507 9.33 HLA-B HLA-DQB1 HLA-DRB1
3 MHC class II protein complex GO:0042613 9.32 HLA-DQB1 HLA-DRB1
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-B HLA-DQB1 HLA-DRB1
5 external side of plasma membrane GO:0009897 9.02 CD4 CD40LG HLA-DRB1 IL17A TNF

Biological processes related to Panuveitis according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.77 CD4 HLA-DQB1 HLA-DRB1
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.76 CD40LG TNF TNFRSF1B
3 cellular response to lipopolysaccharide GO:0071222 9.75 IL10 TNF TNFRSF1B
4 inflammatory response GO:0006954 9.72 CD40LG IL10 IL17A TNF TNFRSF1B
5 apoptotic signaling pathway GO:0097190 9.67 TNF TNFRSF1B UACA
6 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-B HLA-DQB1 HLA-DRB1
7 antigen processing and presentation GO:0019882 9.61 HLA-B HLA-DQB1 HLA-DRB1
8 positive regulation of osteoclast differentiation GO:0045672 9.59 IL17A TNF
9 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.57 IL10 TNF
10 negative regulation of growth of symbiont in host GO:0044130 9.56 IL10 TNF
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.55 TNF TNFRSF1B
12 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.54 HLA-DQB1 HLA-DRB1
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.52 IL10 TNF
14 endothelial cell apoptotic process GO:0072577 9.51 IL10 TNF
15 negative regulation of cytokine secretion involved in immune response GO:0002740 9.46 IL10 TNF
16 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.4 HLA-DQB1 HLA-DRB1
17 regulation of immunoglobulin secretion GO:0051023 9.37 CD40LG TNF
18 immune response GO:0006955 9.28 CD4 CD40LG HLA-B HLA-DQB1 HLA-DRB1 IL10
19 receptor biosynthetic process GO:0032800 9.26 IL10 TNF
20 T cell costimulation GO:0031295 9.26 CD4 CD40LG HLA-DQB1 HLA-DRB1
21 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.16 HLA-DQB1 HLA-DRB1

Molecular functions related to Panuveitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CD40LG IL10 IL17A TNF
2 MHC class II receptor activity GO:0032395 9.16 HLA-DQB1 HLA-DRB1
3 peptide antigen binding GO:0042605 8.8 HLA-B HLA-DQB1 HLA-DRB1

Sources for Panuveitis

3 CDC
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10 dbSNP
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16 ExPASy
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