MCID: PNV001
MIFTS: 52

Panuveitis

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Panuveitis

MalaCards integrated aliases for Panuveitis:

Name: Panuveitis 12 49 51 41 14 69
Diffuse Uveitis 12 49
Inflammation of the Whole Uveal Tract 49
Total Uveitis 49

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:12030
ICD10 32 H44.11
ICD9CM 34 360.12
MeSH 41 D015864
NCIt 46 C84989
SNOMED-CT 64 75614007
UMLS 69 C0030343

Summaries for Panuveitis

NIH Rare Diseases : 49 Panuveitis is inflammation of all layers of the uvea of the eye, which includes the iris, ciliary body, and choroid. These make up the middle layer of the eye. The condition can also affect the lens, retina, optic nerve, and vitreous, causing reduced vision or blindness. Signs and symptoms may include eye redness and pain; blurring; light sensitivity; decreased vision; and seeing floaters. It can last for a short time or can occur chronically. Severe cases may recur many times. In many cases the specific cause is unknown, but in some cases it occurs in association with other eye conditions, or with another condition or infection that also affects other body parts. Early treatment is needed and may include eye drops to reduce inflammation and pain; and/or oral medications or injections in severe cases. Last updated: 11/17/2016

MalaCards based summary : Panuveitis, also known as diffuse uveitis, is related to vogt-koyanagi-harada disease and multifocal choroiditis. An important gene associated with Panuveitis is UACA (Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Th17 cell differentiation. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Panuveitis

Diseases in the Panuveitis family:

Infectious Panuveitis

Diseases related to Panuveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 277)
# Related Disease Score Top Affiliating Genes
1 vogt-koyanagi-harada disease 31.4 HLA-B HLA-DQB1 HLA-DRB1 IL10 IL17A
2 multifocal choroiditis 31.2 IL10 TNF
3 choroiditis 31.2 IL10 TNF
4 punctate inner choroidopathy 30.7 IL10 TNF
5 posterior uveitis 30.4 RBP3 SAG TNF
6 intermediate uveitis 30.2 HLA-B IL10 TNF
7 neurosyphilis 30.1 IL10 IL17A
8 pulmonary tuberculosis 30.0 HLA-DRB1 IL10 TNF
9 hypopyon 30.0 HLA-B MRAP
10 leishmaniasis 29.8 HLA-DRB1 IL10 TNF
11 mycobacterium tuberculosis 1 29.8 IL10 IL17A TNF TNFRSF1B
12 whipple disease 29.7 HLA-DQB1 HLA-DRB1 MRAP
13 dermatitis, atopic 29.7 IL10 IL17A TNF
14 anterior uveitis 29.6 HLA-B TNF
15 pustulosis of palm and sole 29.6 MRAP TNF TNFRSF1B
16 leptospirosis 29.5 CD40LG IL10 TNF
17 crohn's disease 29.5 IL10 TNF TNFRSF1B
18 vasculitis 29.4 CD40LG TNF TNFRSF1B
19 asymptomatic neurosyphilis 29.4 CD40LG IL17A
20 multiple sclerosis 29.4 HLA-DQB1 HLA-DRB1 IL10 IL17A TNF
21 brucellosis 29.3 CD40LG IL10 TNF
22 lyme disease 29.3 CD40LG IL17A TNF
23 uveitis 29.2 HLA-B IL10 IL17A RBP3 SAG TNF
24 pneumonia 29.2 CD40LG IL10 TNF
25 psoriasis 29.1 IL10 IL17A TNF TNFRSF1B
26 chorioretinitis 29.0 CD40LG MRAP RBP3 SAG
27 arthritis 29.0 HLA-DQB1 HLA-DRB1 IL10 IL17A TNF TNFRSF1B
28 acquired immunodeficiency syndrome 28.9 CD40LG HLA-B IL10 TNF
29 graft-versus-host disease 28.8 HLA-B HLA-DQB1 HLA-DRB1 IL10 TNF
30 rubella 28.3 CD40LG HLA-B HLA-DRB1 IL10 TNF
31 idiopathic panuveitis 12.0
32 infectious panuveitis 11.9
33 tropical endomyocardial fibrosis 10.6 IL10 TNF
34 tungiasis 10.5 IL10 TNF
35 endomyocardial fibrosis 10.5 IL10 TNF
36 transient hypogammaglobulinemia 10.5 IL10 TNF
37 juvenile myasthenia gravis 10.5 HLA-DRB1 IL10
38 limbic encephalitis with lgi1 antibodies 10.5 HLA-DQB1 HLA-DRB1
39 trichosporonosis 10.5 IL17A TNF
40 mucocutaneous leishmaniasis 10.5 IL10 TNF
41 trichuriasis 10.5 IL10 TNF
42 metal allergy 10.5 HLA-DQB1 HLA-DRB1
43 focal epithelial hyperplasia 10.4 HLA-DQB1 HLA-DRB1
44 posterior scleritis 10.4 MRAP TNF
45 lichen planopilaris 10.4 HLA-DQB1 HLA-DRB1
46 type ii mixed cryoglobulinemia 10.4 HLA-DQB1 HLA-DRB1
47 clonorchiasis 10.4 IL10 TNF
48 recurrent respiratory papillomatosis 10.4 HLA-DQB1 HLA-DRB1
49 orofacial granulomatosis 10.4 IL10 TNF
50 actinic prurigo 10.4 HLA-DRB1 TNF

Graphical network of the top 20 diseases related to Panuveitis:



Diseases related to Panuveitis

Symptoms & Phenotypes for Panuveitis

GenomeRNAi Phenotypes related to Panuveitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 CD40LG HLA-DQB1 IL10 IL17A TNF TNFRSF1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 CD40LG HLA-DQB1 IL10 IL17A TNF TNFRSF1B

MGI Mouse Phenotypes related to Panuveitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 CD40LG CYP11B1 HLA-DQB1 IL10 IL17A TNF
2 renal/urinary system MP:0005367 9.43 CD40LG CYP11B1 HLA-DQB1 IL17A TNFRSF1B UACA
3 respiratory system MP:0005388 9.1 HLA-DQB1 IL10 IL17A TNF TNFRSF1B UACA

Drugs & Therapeutics for Panuveitis

Drugs for Panuveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 170)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
3
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 67-73-2 6215
4
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
6
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
7
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
8
Chlorambucil Approved Phase 4 305-03-3 2708
9
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2 50-18-0, 6055-19-2 2907
10
Daclizumab Approved, Investigational Phase 4,Phase 2 152923-56-3
11
Infliximab Approved Phase 4,Phase 3,Phase 1,Phase 2 170277-31-3
12
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3 128794-94-5 5281078
13
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
14
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
15
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
16
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
17
Latanoprost Approved, Investigational Phase 4 130209-82-4 5311221 5282380
18
Timolol Approved Phase 4 26839-75-8 5478 33624
19
Travoprost Approved Phase 4 157283-68-6 5282226
20
Bevacizumab Approved, Investigational Phase 4,Phase 3 216974-75-3
21
Certolizumab pegol Approved Phase 4 428863-50-7
22
Maleic acid Experimental Phase 4 110-16-7 444266
23 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
24 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
25 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
26 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
28 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
29 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
30 Hormones Phase 4,Phase 3,Phase 2,Phase 1
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
32 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1
33 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2,Phase 1
34 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1
37 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2,Phase 1
38 Prednisolone phosphate Phase 4,Phase 3,Phase 2,Phase 1
39 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
42 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
44 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
45 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Cyclosporins Phase 4,Phase 3
47 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1
49 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
50 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 148)

# Name Status NCT ID Phase Drugs
1 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
2 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4 flucinolone acetonide
3 Multicenter Uveitis Steroid Treatment (MUST) Trial Completed NCT00132691 Phase 4 fluocinolone acetonide intraocular implant;oral corticosteroid with immunosuppressive agents as needed
4 Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAG Completed NCT01978015 Phase 4 travoprost and timolol maleate fixed combination;latanoprost and maleate timolol fixed combination;bimatoprost and timolol maleate fixed combination;dextran and hypromellose
5 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Completed NCT03133767 Phase 4 Lactated Ringer Solution;Normal Saline 0.9% Infusion Solution Bag
6 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
7 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
8 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Recruiting NCT02769702 Phase 4 Acthar
9 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4 Dexamethasone pellet
10 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
11 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
12 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Active, not recruiting NCT03020992 Phase 4 Certolizumab Pegol
13 Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Unknown status NCT00167583 Phase 3 Cyclosporin A;Interferon-alpha2a
14 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
15 A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis Completed NCT00404742 Phase 3 Placebo;LX211;LX211;LX211
16 A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis Completed NCT00404612 Phase 3 Placebo;LX211;LX211;LX211
17 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Severe Uveitis Completed NCT00407056 Phase 3 Difluprednate Ophthalmic Emulsion
18 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00406887 Phase 3 Difluprednate Ophthalmic Emulsion
19 Phase III Study in Refractory Behcet's Disease Completed NCT00995709 Phase 3 AIN457;AIN457;Placebo
20 Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis Completed NCT01124838 Phase 3 Adalimumab;Prednisone;Placebo
21 A Multi-center Study to Assess the Efficacy and Safety of LX211 in Active Non-infectious Anterior Uveitis Completed NCT00404885 Phase 3 Placebo;LX211;LX211;LX211
22 Efficacy and Safety of Adalimumab in Patients With Active Uveitis Completed NCT01138657 Phase 3 Prednisone;Placebo
23 Efficacy and Safety of Voclosporin to Treat Active Noninfectious Uveitis Completed NCT01243983 Phase 3 LX211
24 Safety and Efficacy of Fluocinolone Acetonide Intravitreal Implants Completed NCT00407082 Phase 2, Phase 3 fluocinolone acetonide intravitreal implant;Fluocinolone acetonide 2.1mg
25 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3 40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
26 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
27 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate or Posterior Uveitis Completed NCT00333814 Phase 2, Phase 3 Dexamethasone;dexamethasone;Sham injection
28 Myfortic for the Treatment of Non-infectious Intermediate Uveitis Completed NCT01092533 Phase 3 Myfortic;Decortin
29 Clinical Study of TA-650 in Patients With Behcet's Disease (BD) With Special Lesions Completed NCT01532570 Phase 3 TA-650
30 A Study of Adalimumab in Japanese Subjects With Intestinal Behçet's Disease Completed NCT01243671 Phase 3
31 Efficacy of Humira in Behcet Patients With Arthritis Completed NCT01497717 Phase 3 Adalimumab (Humira)
32 Intravitreal Bevacizumab for Inflammatory Neovascular Membranes Completed NCT00407121 Phase 3 Bevacizumab
33 Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis Completed NCT00344253 Phase 3 Interferon beta;Methotrexate
34 A Phase 3 Study to Evaluate ADX-102 Ophthalmic Solution in Subjects With Non-infectious Anterior-uveitis. Recruiting NCT03131154 Phase 3 ADX-102 Ophthalmic Solution (0.5%);Vehicle of ADX-102 Ophthalmic Solution
35 Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis Recruiting NCT02517619 Phase 3 Dexamethasone Phosphate Ophthalmic Solution;Prednisolone Acetate Ophthalmic (1%)
36 Interferon α2a Versus Cyclosporine for Refractory Behçet`s Disease Uveitis Recruiting NCT03209219 Phase 3 Interferon Alfa-2A;Cyclosporine Pill
37 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Active, not recruiting NCT01148225 Phase 3 adalimumab
38 A Controlled, Multi-center Study of the Utilization and Safety of the MK II Inserter and the Safety of the FAI Insert in Subjects With Non-infectious Uveitis Affecting the Posterior Segment of the Eye Active, not recruiting NCT02748512 Phase 3 FAI insert
39 Safety and Efficacy Study of a Fluocinolone Acetonide Intravitreal (FAI) Insert in Subjects With Chronic Non-infectious Posterior Uveitis Active, not recruiting NCT02746991 Phase 3 Sham Injection;FAI Insert
40 Safety and Efficacy of an Injectable Fluocinolone Acetonide Intravitreal Insert Active, not recruiting NCT01694186 Phase 3 FAI insert;Sham injection
41 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Active, not recruiting NCT03097315 Phase 3
42 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Active, not recruiting NCT02595398 Phase 3 4mg CLS-TA Suprachoriodal Injection;Sham Procedure
43 A Study to Evaluate Efficacy and Safety of Infliximab in Participant With Moderate-to-Severe Refractory Intestinal Behcet's Disease Active, not recruiting NCT02505568 Phase 3 Infliximab
44 A Phase 3 Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Active Behcet's Disease Active, not recruiting NCT02307513 Phase 3 Apremilast (CC-10004);Placebo
45 Induction Therapy With Anti-TNFα vs Cyclophosphamide in Severe Behçet Disease Not yet recruiting NCT03371095 Phase 3 Infliximab;Cyclophosphamide
46 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01032915 Phase 3 Placebo
47 38 Week Extension Study to CAIN457C2303 Terminated NCT01093846 Phase 3 AIN457;AIN457;Placebo AIN457
48 Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis Terminated NCT01095250 Phase 3 AIN457;AIN457;AIN457;Placebo
49 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01090310 Phase 3 AIN457;Placebo
50 Safety and Efficacy Study of Gevokizumab to Treat Active Non-infectious Uveitis Terminated NCT01684345 Phase 3 Placebo;Dose 1 gevokizumab;Dose 2 gevokizumab

Search NIH Clinical Center for Panuveitis

Cochrane evidence based reviews: panuveitis

Genetic Tests for Panuveitis

Anatomical Context for Panuveitis

MalaCards organs/tissues related to Panuveitis:

38
Eye, Retina, Endothelial, T Cells, Testes, Skin, Neutrophil

Publications for Panuveitis

Articles related to Panuveitis:

(show top 50) (show all 211)
# Title Authors Year
1
Vision-threatening bilateral panuveitis and TRAPS in a child: an uncommon association. ( 29256170 )
2017
2
Panuveitis simulating ocular BehAset's in cases of chronic myelogenous leukaemia in remission. ( 29170182 )
2017
3
Ocular Autoimmune Systemic Inflammatory Infectious Study - Report 3: Posterior and Panuveitis. ( 28991501 )
2017
4
Effect of Adalimumab on Visual Functioning in Patients With Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis in the VISUAL-1 and VISUAL-2 Trials. ( 28426849 )
2017
5
Association Between Long-Lasting Intravitreous Fluocinolone Acetonide Implant vs Systemic Anti-inflammatory Therapy and Visual Acuity at 7 Years Among Patients With Intermediate, Posterior, or Panuveitis. ( 28477440 )
2017
6
A systematic review and economic evaluation of adalimumab and dexamethasone for treating non-infectious intermediate uveitis, posterior uveitis or panuveitis in adults. ( 29183563 )
2017
7
Quality-of-Life Outcomes From a Randomized Clinical Trial Comparing Antimetabolites for Intermediate, Posterior, and Panuveitis. ( 28414043 )
2017
8
Corticosteroid-Related Adverse Events Systematically Increase with Corticosteroid Dose in Noninfectious Intermediate, Posterior, or Panuveitis: Post Hoc Analyses from the VISUAL-1 and VISUAL-2 Trials. ( 28689898 )
2017
9
IgG4-related disease presenting as panuveitis without scleral involvement. ( 28243891 )
2017
10
Severe panuveitis in neuro-BehAset's disease in Malaysia: a case series. ( 28223848 )
2017
11
Panuveitis-like reaction following encircling laser retinopexy/cerclage in a 21-year-old male. ( 29038978 )
2017
12
Dress syndrome and bilateral panuveitis caused by strontium ranelate. ( 28662886 )
2017
13
Morphometric features on enhanced depth imaging optical coherence tomography scans in idiopathic posterior uveitis or panuveitis. ( 28585111 )
2017
14
Toxoplasma gondii-Associated Bilateral Panuveitis and Encephalitis after Bone Marrow Transplantation. ( 29156468 )
2017
15
Enhanced depth imaging optical coherence tomography in patients with different phases of Behcet's panuveitis. ( 28237149 )
2017
16
Re: Jaffe etA al.: Injectable fluocinolone acetonide long-acting implant for noninfectious intermediate uveitis, posterior uveitis, and panuveitis: two-year results (Ophthalmology. 2016;123:1940-1948). ( 28335961 )
2017
17
Multiple myeloma masquerading as panuveitis in a middle-aged woman. ( 29308780 )
2017
18
Re: Jaffe etA al.: Injectable fluocinolone acetonide long-acting implant for noninfectious intermediate uveitis, posterior uveitis, and panuveitis: 2-year results (Ophthalmology. 2016;123:1940-1948). ( 28734339 )
2017
19
Acute hypotony maculopathy following the initiation of a topical aqueous suppressant in a patient with a history of panuveitis without prior filtering surgery. ( 29260088 )
2017
20
Injectable Fluocinolone Acetonide Long-Acting Implant for Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Two-Year Results. ( 27421623 )
2016
21
Risk of Ocular Complications in Patients with Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis. ( 26712559 )
2016
22
Multiple Sclerosis and Panuveitis: A Rare Association. ( 28360778 )
2016
23
A Hemophagocytic Lymphohistiocytosis Patient that Presented With Unilateral Panuveitis. ( 26731243 )
2016
24
Idiopathic Orbital Inflammation Presenting with Bilateral Panuveitis. ( 27112170 )
2016
25
Multifocal choroiditis with panuveitis in an 8-year-old boy with long-standing idiopathic acute anterior uveitis. ( 26951535 )
2016
26
Differentiation of severe bilateral panuveitis following phacoemulsification: a case report. ( 27277218 )
2016
27
TARANTULA HAIR ASSOCIATED PANUVEITIS TREATED WITH SUSTAINED-RELEASE INTRAVITREAL DEXAMETHASONE IMPLANT. ( 27472515 )
2016
28
Choroidal Vascularity Index (CVI)--A Novel Optical Coherence Tomography Parameter for Monitoring Patients with Panuveitis? ( 26751702 )
2016
29
GRAFT-VERSUS-HOST DISEASE PANUVEITIS AND BILATERAL SEROUS DETACHMENTS: MULTIMODAL IMAGING ANALYSIS. ( 27571426 )
2016
30
Human Immunodeficiency Virus-Infected Man With Acute Visual Impairment and Panuveitis Due to Syphilis Despite Initially Negative Rapid Plasma Reagin. ( 27893602 )
2016
31
Long-term Management of Panuveitis and Iris Heterochromia in an Ebola Survivor. ( 27594198 )
2016
32
Nodular Scleritis in Association with Panuveitis in BehAset's Disease. ( 28289688 )
2016
33
Topical difluprednate for treatment of serous retinal detachment and panuveitis associated with Vogt-Koyanagi-Harada disease. ( 27582676 )
2016
34
A Case of Severe Panuveitis Associated with Psoriasis Vulgaris Successfully Treated with Infliximab. ( 27239187 )
2016
35
Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears. ( 27612415 )
2016
36
Direct and indirect resource use, healthcare costs and work force absence in patients with non-infectious intermediate, posterior or panuveitis. ( 26932535 )
2016
37
Dengue Fever-Associated Maculopathy and Panuveitis in Australia. ( 28078150 )
2016
38
Canine panuveitis: a retrospective evaluation of 55 cases (2000-2015). ( 27734587 )
2016
39
A 22 year old woman with bilateral panuveitis and parotid swelling. ( 26265714 )
2015
40
MULTIFOCAL CHOROIDITIS AND PANUVEITIS PRESENTING WITH PROGRESSIVE EQUATORIAL LINEAR STREAKS: EVOLUTION OF SCHLAEGEL LINES DOCUMENTED WITH MULTIMODAL IMAGING. ( 25790317 )
2015
41
Severe bilateral panuveitis during melanoma treatment by Dabrafenib and Trametinib. ( 26078801 )
2015
42
Specific association of IL17A genetic variants with panuveitis. ( 25595174 )
2015
43
Two cases of panuveitis with orbital inflammatory syndrome after influenza vaccination. ( 26455985 )
2015
44
Heterogeneity of primary outcome measures used in clinical trials of treatments for intermediate, posterior, and panuveitis. ( 26286265 )
2015
45
Combination immunotherapy in the treatment of chronic bilateral panuveitis and uveitic glaucoma during acute dengue fever infection in the Caribbean. ( 26229512 )
2015
46
Panuveitis caused by Borrelia burgdorferi sensu lato infection. ( 25741803 )
2015
47
Successful treatment with adalimumab for severe multifocal choroiditis and panuveitis in presumed (early-onset) ocular sarcoidosis. ( 26449230 )
2015
48
Quality of Life and Risks Associated with Systemic Anti-inflammatory Therapy versus Fluocinolone Acetonide Intraocular Implant for Intermediate Uveitis, Posterior Uveitis, or Panuveitis: Fifty-four-Month Results of the Multicenter Uveitis Steroid Treatment Trial and Follow-up Study. ( 26298718 )
2015
49
Positive Immunolabelling for Feline Infectious Peritonitis in an African Lion (Panthera leo) with Bilateral Panuveitis. ( 25678422 )
2015
50
Panuveitis With Exudative Retinal Detachments After Vaccination Against Human Papilloma Virus. ( 26469238 )
2015

Variations for Panuveitis

Expression for Panuveitis

Search GEO for disease gene expression data for Panuveitis.

Pathways for Panuveitis

Pathways related to Panuveitis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 CD40LG HLA-B HLA-DQB1 HLA-DRB1 IL10 IL17A
2
Show member pathways
12.41 HLA-DQB1 HLA-DRB1 IL10 IL17A TNF
3
Show member pathways
12.32 CD40LG IL10 IL17A TNF
4 12.32 CD40LG IL10 IL17A TNF TNFRSF1B
5 12.31 HLA-B HLA-DQB1 HLA-DRB1 TNF
6 12.18 HLA-B HLA-DQB1 HLA-DRB1 IL10
7 12.08 HLA-DQB1 HLA-DRB1 IL10 TNF
8 11.99 HLA-B HLA-DQB1 HLA-DRB1
9
Show member pathways
11.99 CD40LG HLA-DQB1 HLA-DRB1 IL10 TNF TNFRSF1B
10
Show member pathways
11.97 HLA-B IL10 IL17A TNF
11 11.96 CD40LG HLA-B HLA-DQB1 HLA-DRB1
12
Show member pathways
11.91 CD40LG HLA-B HLA-DQB1 HLA-DRB1 IL10 IL17A
13
Show member pathways
11.83 CD40LG HLA-DQB1 HLA-DRB1 IL10 TNF
14
Show member pathways
11.82 IL10 IL17A TNF
15 11.79 HLA-DQB1 HLA-DRB1 TNF
16 11.73 IL10 IL17A TNF TNFRSF1B
17
Show member pathways
11.71 CD40LG TNF TNFRSF1B
18 11.69 IL10 IL17A TNF
19
Show member pathways
11.63 CD40LG TNF TNFRSF1B
20 11.58 CD40LG IL10 TNF
21 11.58 HLA-DQB1 HLA-DRB1 IL17A TNF
22 11.5 HLA-DQB1 HLA-DRB1 IL10
23 11.41 IL10 TNF TNFRSF1B
24 11.4 CD40LG IL10 TNF
25
Show member pathways
11.24 IL10 TNF TNFRSF1B
26 11.09 CD40LG IL10 IL17A TNF
27 11.09 HLA-DRB1 IL10 TNF

GO Terms for Panuveitis

Cellular components related to Panuveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 CD40LG HLA-DRB1 IL17A TNF
2 MHC class II protein complex GO:0042613 9.26 HLA-DQB1 HLA-DRB1
3 ER to Golgi transport vesicle membrane GO:0012507 9.13 HLA-B HLA-DQB1 HLA-DRB1
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-B HLA-DQB1 HLA-DRB1

Biological processes related to Panuveitis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.9 CD40LG IL10 IL17A TNF
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.75 CD40LG TNF TNFRSF1B
3 cellular response to lipopolysaccharide GO:0071222 9.74 IL10 TNF TNFRSF1B
4 T cell costimulation GO:0031295 9.67 CD40LG HLA-DQB1 HLA-DRB1
5 apoptotic signaling pathway GO:0097190 9.65 TNF TNFRSF1B UACA
6 inflammatory response GO:0006954 9.65 CD40LG IL10 IL17A TNF TNFRSF1B
7 interferon-gamma-mediated signaling pathway GO:0060333 9.63 HLA-B HLA-DQB1 HLA-DRB1
8 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.59 IL10 TNF
9 positive regulation of osteoclast differentiation GO:0045672 9.58 IL17A TNF
10 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.56 TNF TNFRSF1B
11 negative regulation of growth of symbiont in host GO:0044130 9.55 IL10 TNF
12 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.54 HLA-DQB1 HLA-DRB1
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.52 IL10 TNF
14 endothelial cell apoptotic process GO:0072577 9.51 IL10 TNF
15 antigen processing and presentation GO:0019882 9.5 HLA-B HLA-DQB1 HLA-DRB1
16 negative regulation of cytokine secretion involved in immune response GO:0002740 9.43 IL10 TNF
17 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.4 HLA-DQB1 HLA-DRB1
18 regulation of immunoglobulin secretion GO:0051023 9.37 CD40LG TNF
19 immune response GO:0006955 9.28 CD40LG CYP11B1 HLA-B HLA-DQB1 HLA-DRB1 IL10
20 receptor biosynthetic process GO:0032800 9.16 IL10 TNF
21 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.96 HLA-DQB1 HLA-DRB1

Molecular functions related to Panuveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CD40LG IL10 IL17A TNF
2 MHC class II receptor activity GO:0032395 9.16 HLA-DQB1 HLA-DRB1
3 peptide antigen binding GO:0042605 8.8 HLA-B HLA-DQB1 HLA-DRB1

Sources for Panuveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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