MCID: PPL018
MIFTS: 44

Papillary Adenocarcinoma malady

Summaries for Papillary Adenocarcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue.

MalaCards: Papillary Adenocarcinoma, also known as infiltrating and papillary adenocarcinoma, is related to adenocarcinoma and papillary carcinoma. An important gene associated with Papillary Adenocarcinoma is FGF3 (fibroblast growth factor 3), and among its related pathways is Keap1-Nrf2 Pathway. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Related mouse phenotype homeostasis/metabolism.

Wikipedia:64 Papillary adenocarcinoma is a histological form of lung cancer that is diagnosed when the malignant... more...

Aliases & Classifications for Papillary Adenocarcinoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
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Aliases & Descriptions:

papillary adenocarcinoma 8 10 61
infiltrating and papillary adenocarcinoma 8
infiltrating papillary adenocarcinoma 8
papillary adenocarcinoma nos 8
adenocarcinoma papillary 45


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Disease Ontology8 DOID:3112
MeSH35 D000231
NCIt40 C2853

Related Diseases for Papillary Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Papillary Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.8CEACAM5, VIM, WT1, SCT, CEACAM7, LAP3
2papillary carcinoma30.9NKX2-1, MUC16, MUC1, NME1, KRT20
3adenoma30.5CEACAM5, CEACAM7, KRT20, F2RL1, NME1, FGF3
4squamous cell carcinoma30.5CEACAM5, CEACAM7, LGALS7, KRT20, F2RL1, NME1
5tubular adenocarcinoma30.3MUC1, KRT20, CEACAM5
6meigs syndrome30.0MUC16
7wilms tumor30.0NKX2-1, WT1, VIM
8thyroid cancer30.0NKX2-1, TYMP, NME1
9transitional cell carcinoma30.0KRT20, NME1, MUC16, TYMP
10aggressive digital papillary adenocarcinoma10.7
11papillary serous adenocarcinoma10.7
12lung papillary adenocarcinoma10.6
13papillary adenoma10.5
14rete testis adenocarcinoma10.4
15fallopian tube papillary adenocarcinoma10.4
16urethra adenocarcinoma10.4
17papillary squamous carcinoma10.3
18peritoneal serous papillary adenocarcinoma10.3
19gastric papillary adenocarcinoma10.3
20eccrine papillary adenocarcinoma10.3
21bile duct adenocarcinoma10.3
22ureter adenocarcinoma10.3
23renal pelvis adenocarcinoma10.2
24bladder adenocarcinoma10.2
25seminal vesicle adenocarcinoma10.2
26papillary cystadenocarcinoma10.2
27duodenum adenocarcinoma10.2
28papillary thymic adenocarcinoma10.2
29hypercalcemia10.2
30mucinous adenocarcinoma10.2
31breast adenocarcinoma10.2
32pheochromocytoma10.2
33thyroid adenoma10.2
34paronychia10.0
35squamous cell papilloma10.0
36renal wilms' tumor10.0
37intraductal papilloma10.0
38ethmoid sinus adenocarcinoma10.0
39malignant peritoneal mesothelioma10.0
40hepatitis c10.0
41obstructive jaundice10.0
42renal agenesis10.0
43clear cell adenocarcinoma10.0
44hepatitis e10.0
45cervix melanoma10.0
46primary hyperparathyroidism10.0
47parotid gland cancer10.0
48pulmonary sclerosing hemangioma10.0
49urethral diverticulum10.0
50myoblastoma10.0

Graphical network of the top 20 diseases related to Papillary Adenocarcinoma:



Diseases related to papillary adenocarcinoma

Clinical Features for Papillary Adenocarcinoma

Drugs & Therapeutics for Papillary Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Papillary Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Papillary Adenocarcinoma

Search NIH Clinical Center for Papillary Adenocarcinoma

Search CenterWatch for Papillary Adenocarcinoma

Genetic Tests for Papillary Adenocarcinoma

Anatomical Context for Papillary Adenocarcinoma

Animal Models for Papillary Adenocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Papillary Adenocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.2F2RL1, SCT

Publications for Papillary Adenocarcinoma

Sources:
51PubMed
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Articles related to Papillary Adenocarcinoma:

(show top 50)    (show all 394)
idTitleAuthorsYear
1
Metachronous pancreatic metastasis of an ovarian serous papillary adenocarcinoma after 8 years. (24294516)
2013
2
Disease spectrum of intraductal papillary mucinous neoplasm with an associated invasive carcinoma invasive IPMN versus pancreatic ductal adenocarcinoma-associated IPMN. (24308063)
2013
3
Low papillary structure in lepidic growth component of lung adenocarcinoma: a unique histologic hallmark of aggressive behavior. (23648380)
2013
4
Pathological implication and function of Bcl2-inhibitor of transcription in ovarian serous papillary adenocarcinomas. (23259782)
2013
5
The medial plantar flap vascularized by the reverse flow lateral plantar artery: a novel variation through the case of aggressive digital papillary adenocarcinoma of the sole. (22711199)
2012
6
Cystic papillary pattern in pancreatic ductal adenocarcinoma: a heretofore undescribed morphologic pattern that mimics intraductal papillary mucinous carcinoma. (22367300)
2012
7
Incidental primary papillary mucinous adenocarcinoma of the renal pelvis in a case of non-functioning kidney due to chronic pyelonephritis and pelvic calculus. (22569454)
2012
8
Cutaneous digital papillary adenocarcinoma: a clinicopathologic study of 31 cases of a rare neoplasm with new observations. (23026931)
2012
9
Nuclear atypia grading score is a useful prognostic factor in papillary gastric adenocarcinoma. (22092395)
2011
10
Papillary adenocarcinoma arising in a duplication of the cecum. (17912582)
2008
11
Villoglandular papillary adenocarcinoma of cervix associated with cervical intraepithelial neoplasia: a case report and review of literature. (18306568)
2007
12
Aggressive digital papillary adenocarcinoma: a silent malignancy masquerading as acquired digital fibrokeratoma. (17645380)
2007
13
Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma. (17909725)
2007
14
Canine ovarian serous papillary adenocarcinoma with neoplastic hypercalcemia. (17019069)
2006
15
Aggressive Digital Papillary Adenocarcinoma in a 15-year-old Female. (16912593)
2006
16
Aggressive digital papillary adenocarcinoma presenting as a paronychia of the finger. (16055244)
2005
17
Papillary adenocarcinoma of the extrahepatic bile duct in a Holstein cow. (15657275)
2005
18
Renal papillary adenocarcinoma with unusual metastases: case report and review of the literature. (15270421)
2004
19
Immunophenotypic differences between intestinal-type and low-grade papillary sinonasal adenocarcinomas: an immunohistochemical study of 22 cases utilizing CDX2 and MUC2. (15252308)
2004
20
Invasive papillary adenocarcinoma of the colon: is it really a distinct subtype? (12514795)
2002
21
Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma. (12010891)
2002
22
Long-term surgical outcome of noninvasive and minimally invasive intraductal papillary mucinous adenocarcinoma of the pancreas. (12045867)
2002
23
Accumulation of Tc-99m HMDP in ovarian serous papillary adenocarcinoma reflecting ongoing calcification. (11564940)
2001
24
The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma. (11420467)
2001
25
Aggressive digital papillary adenocarcinoma of the foot: the clinicopathologic features of two cases. (11131478)
2000
26
Papillary adenocarcinoma of the stomach. (11984707)
2000
27
Polymorphous low-grade adenocarcinoma: a study of 40 cases with long-term follow up and an evaluation of the importance of papillary areas. (11023093)
2000
28
The combination paclitaxel, carboplatin and megestrol acetate is effective in women with recurrent uterine papillary serous adenocarcinoma. (10422674)
1999
29
Endoscopic management of low-grade papillary adenocarcinoma of the ethmoid sinus: case report and review of the literature. (10326758)
1999
30
Well-differentiated papillary adenocarcinoma arising in a supratentorial enterogenous cyst: case report. (9848864)
1998
31
Papillary adenocarcinoma of the sigmoid colon associated with psammoma bodies and hyaline globules: report of a case. (9255277)
1997
32
Cystic papillary adenocarcinoma of the submandibular gland in a child. (8791913)
1996
33
Papillary adenocarcinoma of the rete testis: a case report and review of the literature. (7941203)
1994
34
Papillary adenocarcinoma of the endometrium: a retrospective study of stage I and II disease. (8169986)
1994
35
Expression of EGFR, HER-2/neu, P53, and PCNA in endometrioid, serous papillary, and clear cell endometrial adenocarcinomas. (7909788)
1994
36
Papillary adenocarcinoma possibly arising from an intraductal papilloma of the parotid gland. (8177584)
1994
37
Uterine papillary serous adenocarcinoma. A 10-case study of p53 and c-erbB-2 expression and DNA content. (7915964)
1994
38
Papillary adenocarcinoma of the thyroid gland metastasizing in to the epidural space of the upper thoracic spine, without vertebral involvement--case report. (7976670)
1993
39
Papillary serous adenocarcinoma of the uterine cervix: a report of three cases. (1495949)
1992
40
Papillary adenocarcinoma in a seminal vesicle cyst associated with ipsilateral renal agenesis: a case report. (1433569)
1992
41
Metastatic papillary adenocarcinoma to the brain simulating toxoplasmosis on CT in a patient with AIDS. (1503052)
1992
42
Papillary adenocarcinoma of minor salivary gland origin in a child. (6639458)
1983
43
Tumor calcification in renal papillary adenocarcinoma. (6649243)
1983
44
Papillary adenocarcinoma of the rete testis: a case report. (7083116)
1982
45
Carcinoma of the endometrium. II. Papillary adenocarcinoma: a clinical pathological study, 46 cases. (7081149)
1982
46
A papillary adenocarcinoma of the renal pelvis in a young girl. A light- and electron-microscopic study. (7361725)
1980
47
A papillary adenocarcinoma of the vagina in an infant. (13877877)
1962
48
Papillary adenocarcinoma arising in a thyroglossal duct cyst. Report of a case. (13867693)
1961
49
Papillary adenocarcinoma of the kidney, with aortography resembling huge renal cyst. (13184568)
1954
50
Papillary adenocarcinoma arising in association with a persistent thyroglossal duct. (13092818)
1953

Genetic Variations for Papillary Adenocarcinoma

Expression for genes affiliated with Papillary Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papillary Adenocarcinoma

Search GEO for disease gene expression data for Papillary Adenocarcinoma.

Pathways for genes affiliated with Papillary Adenocarcinoma

Sources:
38NCBI BioSystems Database
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Pathways related to Papillary Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1NFE2L2, KEAP1

Compounds for genes affiliated with Papillary Adenocarcinoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
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Compounds related to Papillary Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7CEACAM7
2butyrate4510.5LAP3, CEACAM7
3prostaglandin4510.5VIM, SCT
4eosin4510.3VIM, MUC1
5slex4510.3NME1, MUC1, CEACAM5
6crcs4510.2TYMP, NME1, CEACAM5, MUC1
7biotin45 11 2412.2NME1, VIM, MUC1, SCT
8dexamethasone45 50 29 1113.2NFE2L2, NKX2-1, MUC16, NME1
9p0034510.2NFE2L2, CEACAM5, F2RL1, TYMP
10diethylmaleate4510.1NFE2L2, KEAP1
11formaldehyde45 2411.1MUC1, KRT20, TYMP, NKX2-1, VIM
12gold4510.1MUC1, CEACAM5, SCT, MUC16
13chloramphenicol45 2 1112.1WT1, VIM, NFE2L2, MUC1
1412-o-tetradecanoylphorbol 13-acetate4510.1NFE2L2, MUC1, TYMP, WT1, VIM
15cycloheximide4510.1CEACAM7, TYMP
16actinomycin d4510.0TYMP, VIM, F2RL1, MUC1, CEACAM7
175fluorouracil4510.0NME1, MUC1, CEACAM7, TYMP, CEACAM5
18forskolin45 50 1112.0F2RL1, MUC1, VIM, NKX2-1, WT1, SCT
19matrigel4510.0NME1, MUC1, VIM, TYMP
20hematoxylin4510.0MUC16, KRT20, NKX2-1, VIM, CEACAM5
21lysine459.9KEAP1, SCT, VIM, WT1, NFE2L2, F2RL1
22agar459.9MUC1, FGF3, NME1, LAP3, VIM, CEACAM5
23ribonucleic acid459.9NME1, MUC1, NKX2-1, WT1, KRT20, CEACAM5
24etoposide45 50 60 1112.9NME1, NFE2L2, WT1, VIM
25nitric oxide45 11 2411.9NFE2L2, MUC1, F2RL1, TYMP, WT1, NME1
26s 100459.9MUC1, VIM
27cisplatin45 50 60 1112.9TYMP, NME1, MUC1, CEACAM5, MUC16
28cyclic amp45 2410.8SCT, NKX2-1, NFE2L2, MUC1, VIM
29leucine459.8KEAP1, VIM, NFE2L2, F2RL1, LAP3
30iron45 2410.8MUC16, KRT20, NFE2L2, LAP3, VIM
31lactate459.8NME1, VIM, MUC16, LAP3, CEACAM5
32steroid459.8NME1, FGF3, MUC16, NFE2L2, NKX2-1, WT1
33hyaluronic acid45 2410.8KRT20, CEACAM5, VIM, WT1, MUC16, MUC1
34oligonucleotide459.8NFE2L2, NME1, SCT, WT1, VIM, F2RL1
35doxorubicin45 50 1111.8CEACAM5, KRT20, TYMP, WT1, VIM, MUC16
36mucicarmine459.7CEACAM5, VIM, PIP, NKX2-1, CEACAM7, KRT20
37estradiol45 11 2411.7MUC16, TYMP, PIP, SCT, VIM, MUC1
38creatinine459.7NME1, MUC16, TYMP, LAP3, WT1, VIM
39thymidine45 2410.7CEACAM7, NME1, MUC1, TYMP, CEACAM5, SCT
40testosterone45 60 11 2412.7MUC16, KRT20, MUC1, PIP, SCT, WT1
41glucose459.7MUC16, CEACAM5, LAP3, NFE2L2, SCT, TYMP
42lipid459.6MUC1, NFE2L2, LAP3, CEACAM5, SCT, VIM
43retinoic acid45 2410.5WT1, SCT, CEACAM7, LAP3, NME1, MUC1
44b 723459.4PIP, NKX2-1, CEACAM5, CEACAM7, KRT20, MUC1
45serine459.2F2RL1, NKX2-1, TYMP, MUC16, MUC1, NME1
46cysteine459.2NME1, MUC1, VIM, CEACAM5, WT1, SCT
47tyrosine459.2SCT, NKX2-1, CEACAM5, KRT20, NFE2L2, NME1
48paraffin459.1KRT20, F2RL1, NME1, MUC1, MUC16, VIM
49vegf459.1VIM, WT1, TYMP, MUC1, FGF3, MUC16
50progesterone45 60 29 11 2413.1MUC1, KRT20, CEACAM5, CEACAM7, WT1, PIP

GO Terms for genes affiliated with Papillary Adenocarcinoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Papillary Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:04510910.1KRT20, VIM
2proteasomal ubiquitin-independent protein catabolic processGO:01049910.1NFE2L2, KEAP1
3positive regulation of transcription from RNA polymerase II promoter in response to stressGO:0360039.9MUC1, NFE2L2

Molecular functions related to Papillary Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.5KRT20, WT1, KEAP1, NKX2-1, NFE2L2, MUC16

Products for genes affiliated with Papillary Adenocarcinoma

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Sources for Papillary Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet