MCID: PPL018
MIFTS: 50

Papillary Adenocarcinoma malady

Summaries for Papillary Adenocarcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue.

MalaCards: Papillary Adenocarcinoma, also known as infiltrating and papillary adenocarcinoma, is related to adenocarcinoma and papillary carcinoma. An important gene associated with Papillary Adenocarcinoma is FGF3 (fibroblast growth factor 3), and among its related pathways is Keap1-Nrf2 Pathway. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lung and cervix, and related mouse phenotype homeostasis/metabolism.

Wikipedia:63 Papillary adenocarcinoma is a histological form of lung cancer that is diagnosed when the malignant... more...

Aliases & Classifications for Papillary Adenocarcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

papillary adenocarcinoma 8 10 60
infiltrating and papillary adenocarcinoma 8
infiltrating papillary adenocarcinoma 8
papillary adenocarcinoma nos 8
adenocarcinoma papillary 44


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Disease Ontology8 DOID:3112
MeSH34 D000231
NCIt39 C2853

Related Diseases for Papillary Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Papillary Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.7CEACAM5, VIM, WT1, SCT, CEACAM7, LAP3
2papillary carcinoma30.9NKX2-1, MUC16, MUC1, NME1, KRT20
3lung adenocarcinoma30.8PIP, NKX2-1, TYMP, MUC16, MUC1, KRT20
4adenoma30.5CEACAM5, CEACAM7, KRT20, F2RL1, NME1, FGF3
5squamous cell carcinoma30.4CEACAM5, CEACAM7, LGALS7, KRT20, F2RL1, NME1
6peritonitis30.4MUC16
7hepatitis30.4TYMP
8colon adenocarcinoma30.4F2RL1, KRT20, CEACAM7, CEACAM5
9tubular adenocarcinoma30.3MUC1, KRT20, CEACAM5
10pancreatitis30.1F2RL1, SCT
11cystadenocarcinoma30.1MUC16, MUC1, CEACAM5
12cervical adenocarcinoma30.1MUC16, NME1, KRT20, CEACAM7, CEACAM5
13malignant mesothelioma30.1VIM, WT1, NKX2-1, MUC16, MUC1, KRT20
14hemangioma29.9NKX2-1
15retinoblastoma29.9WT1, FGF3, NME1
16thyroid cancer29.9NKX2-1, TYMP, NME1
17transitional cell carcinoma29.9KRT20, NME1, MUC16, TYMP
18ovarian cancer29.9TYMP, MUC16, MUC1, FGF3, NME1
19melanoma29.9VIM, NKX2-1, FGF3, NME1, F2RL1, LAP3
20gastric adenocarcinoma29.9TYMP, MUC16, NME1, F2RL1, KRT20, CEACAM7
21thyroiditis10.8
22aggressive digital papillary adenocarcinoma10.7
23papillary serous adenocarcinoma10.7
24lung papillary adenocarcinoma10.6
25ovary adenocarcinoma10.5
26pancreas adenocarcinoma10.4
27nasopharyngitis10.4
28papillary adenoma10.4
29prostate adenocarcinoma10.4
30prostatitis10.4
31rete testis adenocarcinoma10.4
32fallopian tube papillary adenocarcinoma10.4
33mucinous adenocarcinoma10.4
34papillary thyroid carcinoma10.4
35papillary squamous carcinoma10.3
36peritoneal serous papillary adenocarcinoma10.3
37gastric papillary adenocarcinoma10.3
38eccrine papillary adenocarcinoma10.3
39bile duct adenocarcinoma10.3
40gallbladder adenocarcinoma10.3
41urethra adenocarcinoma10.3
42ureter adenocarcinoma10.3
43ovary serous adenocarcinoma10.3
44renal pelvis adenocarcinoma10.2
45bladder adenocarcinoma10.2
46hyperthyroidism10.2
47peritoneal serous adenocarcinoma10.2
48seminal vesicle adenocarcinoma10.1
49papillary cystadenocarcinoma10.1
50duodenum adenocarcinoma10.1

Graphical network of the top 20 diseases related to Papillary Adenocarcinoma:



Diseases related to papillary adenocarcinoma

Clinical Features for Papillary Adenocarcinoma

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Drugs & Therapeutics for Papillary Adenocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Genetic Tests for Papillary Adenocarcinoma

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Anatomical Context for Papillary Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Papillary Adenocarcinoma:

32
Thyroid, Lung, Cervix, Pancreas, Ovary, Lymph node, Prostate, Testis, Salivary gland, Kidney, Colon, Breast, Brain, Pituitary, Bone, Uterus, Testes, Thymus, Tongue, Appendix

Animal Models for Papillary Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Papillary Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.2F2RL1, SCT

Publications for Papillary Adenocarcinoma

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50PubMed
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Articles related to Papillary Adenocarcinoma:

(show top 50)    (show all 393)
idTitleAuthorsYear
1
Low papillary structures in lepidic lung adenocarcinoma: any relationship with micropapillary lung adenocarcinoma? (24054172)
2013
2
Thyroid-like papillary adenocarcinoma of the nasopharynx with focal thyroglobulin expression. (24018817)
2013
3
Papillary adenocarcinoma of ciliary body. (24082678)
2013
4
Duodenal adenocarcinoma with neuroendocrine features in a patient with acromegaly and thyroid papillary adenocarcinoma: a unique combination of endocrine neoplasia. (22673565)
2012
5
Neoadjuvant erlotinib and surgical resection of a stage iiia papillary adenocarcinoma of the lung with an L861Q activating EGFR mutation. (22670114)
2012
6
Intraductal papillary mucinous adenocarcinoma of the pancreas: clinical outcomes, prognostic factors, and the role of adjuvant therapy. (22368734)
2011
7
Biphasic low-grade nasopharyngeal papillary adenocarcinoma with a prominent spindle cell component: report of a case localized to the posterior nasal septum. (21424532)
2011
8
A case of villoglandular papillary adenocarcinoma of the cervix with vaginal skip metastasis. (24371586)
2011
9
Aggressive digital papillary adenocarcinoma: a review. (19874325)
2010
10
Acute gastric outlet obstruction secondary to papillary serous adenocarcinoma of the endometrium with peritoneal psammomatous implants: a case report. (19132421)
2010
11
Papillary adenocarcinoma of thyroid in a patient with right submandibular mass--a rare case of 'lateral aberrant thyroid'. (19803039)
2009
12
Aggressive digital papillary adenocarcinoma: a report of two diseases and review of the literature. (18819728)
2009
13
Villoglandular papillary adenocarcinoma of the uterine cervix: a diagnostic challenge. (19172445)
2009
14
99mTc-MDP and 18F-FDG uptake in calcified metastatic lesions from ovarian papillary serous adenocarcinoma. (19936349)
2009
15
Aggressive digital papillary adenocarcinoma on the palm with pulmonary metastases. (18705837)
2008
16
Low-grade papillary adenocarcinoma of the palate: the significance of distinguishing it from polymorphous low-grade adenocarcinoma. (20614302)
2008
17
Different gene-expression profiles for the poorly differentiated carcinoma and the highly differentiated papillary adenocarcinoma in mammary glands support distinct metabolic pathways. (18811984)
2008
18
Unknown primary site of serous papillary adenocarcinoma involving inguinal, iliac and obturator lymph nodes co-existing with endometrial adenocarcinoma. (17701821)
2007
19
Salivary gland cystadenocarcinoma of the mobile tongue, low-grade papillary adenocarcinoma variant: a case report. (17240709)
2006
20
Thyroid transcription factor-1 expression in thyroid-like nasopharyngeal papillary adenocarcinoma: report of 2 cases. (16084450)
2005
21
Peritoneal serous papillary adenocarcinoma: report of four cases. (16258208)
2005
22
Villoglandular papillary adenocarcinoma of the uterine cervix responding to neoadjuvant chemotherapy with docetaxel and cisplatin: a case report. (16343210)
2005
23
Aspiration cytology of the oncocytic variant of papillary adenocarcinoma of the thyroid gland. (15085743)
2004
24
Inferior head resection of the pancreas for noninvasive intraductal papillary mucinous adenocarcinoma. (15011879)
2004
25
Aggressive digital papillary adenocarcinoma presenting as finger infection. (12351985)
2002
26
Nonmucin-producing intraductal papillary adenocarcinoma of the pancreas in a young woman. (11677487)
2001
27
Hyperthyroidism in a patient with TSH-producing pituitary adenoma coexisting with thyroid papillary adenocarcinoma. (11228048)
2000
28
Multiple nodular metastases in mesenteric panniculitis by uterine papillary serous adenocarcinoma (UPSC): CT appearance of a case. (10416083)
1999
29
Expression of CD44V6 and nm23-H1 in thyroid papillary adenocarcinoma and lymph node metastasis]. (10681781)
1998
30
Papillary adenocarcinoma arising in placentoid bullous lesion of the lung: report of a case with immunohistochemical study. (9786354)
1998
31
Histologic characterization of uterine papillary serous adenocarcinoma. (7705679)
1995
32
Expression of adhesion molecule ICAM-1 (CD54) in thyroid papillary adenocarcinoma. (7538157)
1994
33
Serous papillary adenocarcinoma of the endometrium. A unique entity with a grave prognosis. Case report and review of the literature. (8472732)
1993
34
Low-grade papillary adenocarcinoma of buccal mucosa salivary gland origin. (2656584)
1989
35
Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations. (3301927)
1987
36
Papillary adenocarcinoma of the broad ligament. Report of a case and review of literature. (3100180)
1986
37
Papillary adenocarcinoma of lung with psammoma bodies: report of a case derived from type II pneumocytes. (3758952)
1986
38
Psammoma bodies in papillary adenocarcinoma of the endocervix. (6629634)
1983
39
Renal papillary adenocarcinoma following treatment for Wilms' tumor. (6305478)
1983
40
Radionuclide salivary scan imaging of a "functioning" malignant parotid tumor (mucous-producing papillary adenocarcinoma). (7077733)
1982
41
Metastases in epididymides from papillary adenocarcinoma of prostate. (7314363)
1981
42
Papillary adenocarcinoma of a thyroglossal duct cyst. (910177)
1977
43
Papillary adenocarcinoma of thyroid invading the larynx. (1009864)
1976
44
Papillary adenocarcinoma of the endometrium with psammoma bodies. (4853530)
1974
45
Papillomatosis and papillary adenocarcinoma of prostatic ducts: a case report. (5532917)
1970
46
Papillary adenocarcinoma in a thyroglossal cyst. Case report and review of the literature. (5939053)
1966
47
Primary hyperparathyroidism and papillary adenocarcinoma of the thyroid; report of four cases. (13323049)
1956
48
Papillary adenocarcinoma of the thyroid (so-called "lateral aberrant thyroid"). (13189847)
1954
49
Carcinoma of the thyroid: papillary adenocarcinoma occurring in twins and a case of HA1rthle cell carcinoma; tumor conference. (13143294)
1953
50
A transplantable ovarian papillary adenocarcinoma of the rat with ascites implants in the ovary. (12991049)
1952

Genetic Variations for Papillary Adenocarcinoma

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Expression for genes affiliated with Papillary Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papillary Adenocarcinoma

Search GEO for disease gene expression data for Papillary Adenocarcinoma.

Pathways for genes affiliated with Papillary Adenocarcinoma

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37NCBI BioSystems Database
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Pathways related to Papillary Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1NFE2L2, KEAP1

Compounds for genes affiliated with Papillary Adenocarcinoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Papillary Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CEACAM7
2butyrate4410.5LAP3, CEACAM7
3prostaglandin4410.5SCT, VIM
4eosin4410.3MUC1, VIM
5slex4410.3MUC1, NME1, CEACAM5
6crcs4410.2TYMP, MUC1, NME1, CEACAM5
7biotin44 11 2412.2NME1, MUC1, SCT, VIM
8dexamethasone44 49 28 1113.2NKX2-1, NFE2L2, MUC16, NME1
9p0034410.2NFE2L2, TYMP, F2RL1, CEACAM5
10diethylmaleate4410.1NFE2L2, KEAP1
11formaldehyde44 2411.1KRT20, MUC1, TYMP, NKX2-1, VIM
12gold4410.1CEACAM5, MUC1, MUC16, SCT
13chloramphenicol44 2 1112.1MUC1, NFE2L2, WT1, VIM
1412-o-tetradecanoylphorbol 13-acetate4410.1MUC1, TYMP, NFE2L2, WT1, VIM
15cycloheximide4410.1CEACAM7, TYMP
16actinomycin d4410.0VIM, TYMP, MUC1, F2RL1, CEACAM7
175fluorouracil4410.0TYMP, MUC1, NME1, CEACAM7, CEACAM5
18forskolin44 49 1112.0VIM, WT1, SCT, NKX2-1, MUC1, F2RL1
19matrigel4410.0VIM, TYMP, MUC1, NME1
20hematoxylin4410.0VIM, NKX2-1, MUC16, KRT20, CEACAM5
21lysine449.9VIM, WT1, SCT, KEAP1, NFE2L2, F2RL1
22agar449.9VIM, MUC1, FGF3, NME1, LAP3, CEACAM5
23ribonucleic acid449.9WT1, NKX2-1, MUC1, NME1, KRT20, CEACAM5
24etoposide44 49 59 1112.9VIM, WT1, NFE2L2, NME1
25nitric oxide44 11 2411.9WT1, NFE2L2, TYMP, MUC1, NME1, F2RL1
26s 100449.9MUC1, VIM
27cisplatin44 49 59 1112.9TYMP, MUC16, MUC1, NME1, CEACAM5
28cyclic amp44 2410.8MUC1, NFE2L2, NKX2-1, SCT, VIM
29leucine449.8VIM, KEAP1, NFE2L2, F2RL1, LAP3
30iron44 2410.8VIM, NFE2L2, MUC16, KRT20, LAP3
31lactate449.8VIM, MUC16, NME1, LAP3, CEACAM5
32steroid449.8WT1, PIP, NKX2-1, NFE2L2, MUC16, FGF3
33hyaluronic acid44 2410.8VIM, WT1, MUC16, MUC1, KRT20, CEACAM5
34oligonucleotide449.8VIM, WT1, SCT, NKX2-1, NFE2L2, FGF3
35doxorubicin44 49 1111.8VIM, WT1, TYMP, MUC16, KRT20, CEACAM5
36mucicarmine449.7VIM, PIP, NKX2-1, MUC1, KRT20, CEACAM7
37estradiol44 11 2411.7VIM, SCT, PIP, TYMP, MUC16, MUC1
38creatinine449.7VIM, WT1, TYMP, MUC16, MUC1, NME1
39thymidine44 2410.7WT1, SCT, TYMP, MUC1, NME1, F2RL1
40testosterone44 59 11 2412.7VIM, WT1, SCT, PIP, MUC16, MUC1
41glucose449.7SCT, NFE2L2, TYMP, MUC16, MUC1, LAP3
42lipid449.6VIM, SCT, NFE2L2, MUC1, F2RL1, LAP3
43retinoic acid44 2410.5VIM, WT1, SCT, NKX2-1, MUC1, NME1
44b 723449.4CEACAM5, VIM, WT1, CEACAM7, KRT20, MUC1
45serine449.2VIM, WT1, SCT, NKX2-1, NFE2L2, TYMP
46cysteine449.2VIM, WT1, SCT, KEAP1, NFE2L2, TYMP
47tyrosine449.2WT1, SCT, NKX2-1, NFE2L2, TYMP, MUC16
48paraffin449.1VIM, WT1, PIP, NKX2-1, TYMP, MUC16
49vegf449.1VIM, WT1, TYMP, MUC16, MUC1, FGF3
50progesterone44 59 28 11 2413.1NKX2-1, PIP, WT1, VIM, TYMP, MUC16

GO Terms for genes affiliated with Papillary Adenocarcinoma

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16Gene Ontology
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Biological processes related to Papillary Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:04510910.1KRT20, VIM
2proteasomal ubiquitin-independent protein catabolic processGO:01049910.1NFE2L2, KEAP1
3positive regulation of transcription from RNA polymerase II promoter in response to stressGO:0360039.9MUC1, NFE2L2

Molecular functions related to Papillary Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.5KRT20, WT1, KEAP1, NKX2-1, NFE2L2, MUC16

Products for genes affiliated with Papillary Adenocarcinoma

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Sources for Papillary Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet