MCID: PPL002
MIFTS: 56

Papillary Carcinoma malady

Cancer diseases category

Summaries for Papillary Carcinoma

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Disease Ontology:10 A carcinoma that is derived from epithelial cells with finger like projections.

MalaCards based summary: Papillary Carcinoma, also known as papillary carcinoma nos, is related to thyroiditis and adenoma. An important gene associated with Papillary Carcinoma is MET (met proto-oncogene), and among its related pathways are Thyroid cancer and Development Hedgehog and PTH signaling pathways in bone and cartilage development. The compounds pf 04217903 mesylate and su 11274 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, breast and lymph node, and related mouse phenotypes are endocrine/exocrine gland and no phenotypic analysis.

Aliases & Classifications for Papillary Carcinoma

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Sources:
10Disease Ontology, 45Novoseek, 62UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
See all sources

Papillary Carcinoma, Aliases & Descriptions:

Name: Papillary Carcinoma 10
Papillary Carcinoma Nos 10
 
Carcinoma, Papillary 62
Carcinoma Papillary 45


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology10 DOID:3113
MeSH35 D002291
SNOMED-CT57 189562005, 25910003
NCIt40 C2927

Related Diseases for Papillary Carcinoma

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Diseases related to Papillary Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.9TG, CALCA
2adenoma30.9TG, CCND1, NKX2-1, CALCA, RET, LGALS3
3follicular adenoma30.9LGALS3
4breast papillary carcinoma30.7ERC1
5parathyroid adenoma30.6CCND1, LGALS3, RET, CALCA
6multinodular goiter30.5CALCA, TG
7graves' disease30.5TG, FOXE1, LGALS3, NKX2-1
8struma ovarii30.5TG, NKX2-1
9goiter30.5NKX2-1, CALCA, LGALS3, RET, SLC5A5, TG
10teratoma30.3NKX2-1, TG
11thyroid carcinoma, papillary30.3TG, RET, MET, LGALS3
12thyroid cancer30.3NKX2-1, CALCA, TG, RET, MET, LGALS3
13hypothyroidism30.2TG, NKX2-1
14mesothelioma30.2HGF, MET, NKX2-1
15hemangioma30.2RET, NKX2-1, ANGPT2
16adenocarcinoma30.2CCND1, IBSP, KRT1, MET, NKX2-1, HGF
17primary hyperparathyroidism30.2RET, CALCA, IBSP
18mucoepidermoid carcinoma30.2TG, CALCA
19thyroid adenoma30.0LGALS3, RET, TG
20autoimmune thyroiditis30.0TG, CALCA
21thyroid carcinoma, follicular30.0CALCA, TG
22congenital hypothyroidism30.0TG, FOXE1, NKX2-1, SLC5A5
23hashimoto thyroiditis29.9TG, CALCA, LGALS3, RET
24melanoma29.9IBSP, MET, HGF, NKX2-1, CCND1, LGALS3
25breast cancer29.8ANGPT2, CCND1, HGF, IBSP, CALCA, MET
26peritonitis10.6
27cervicitis10.6
28renal cell carcinoma, papillary10.5
29papilloma10.5
30primary peritoneal serous/papillary carcinoma10.5
31intraductal papilloma10.3
32ovary papillary carcinoma10.3
33leukemia10.3
34gallbladder papillary carcinoma10.3
35tall cell variant papillary carcinoma10.3
36papillary transitional carcinoma10.3
37kidney pelvis papillary carcinoma10.3
38hyperparathyroidism10.3
39primary peritoneal carcinoma10.3
40thyroid carcinoma, papillary, with papillary renal neoplasia10.2
41columnar cell variant papillary carcinoma10.2
42ductal carcinoma in situ10.2
43metanephric adenoma10.2
44choroiditis10.2
45fasciitis10.2
46mediastinitis10.2
47pancreatitis10.2
48papillary carcinoma of the cervix uteri10.2
49thyroid hemiagenesis10.2
50renal cell carcinoma10.1

Graphical network of the top 20 diseases related to Papillary Carcinoma:



Diseases related to papillary carcinoma

Symptoms for Papillary Carcinoma

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Drugs & Therapeutics for Papillary Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Papillary Carcinoma

Search NIH Clinical Center for Papillary Carcinoma

Genetic Tests for Papillary Carcinoma

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Anatomical Context for Papillary Carcinoma

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MalaCards organs/tissues related to Papillary Carcinoma:

33
Thyroid, Breast, Lymph node, Ovary, Kidney, Lung, Pancreas, Bone, Thymus, Brain, Colon, Skin, B cells, Bone marrow, Liver, Salivary gland, Prostate, Testis, Testes, T cells, Endothelial, Tongue, Pituitary, Nk cells

Animal Models for Papillary Carcinoma or affiliated genes

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Publications for Papillary Carcinoma

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Articles related to Papillary Carcinoma:

(show top 50)    (show all 668)
idTitleAuthorsYear
1
Frequency and Pattern of Central Lymph Node Metastasis in Papillary Carcinoma of the Thyroid Isthmus. (25581039)
2015
2
Cytomorphology of columnar cell variant of papillary carcinoma thyroid: A case report and review of the literature. (25379049)
2014
3
Thyroid type papillary carcinoma arising in a mature teratoma. (25419058)
2014
4
Recurrent thyroid papillary carcinoma in children under ten years old: report of two cases and literature review. (25214862)
2014
5
Renal papillary carcinoma: CT and MRI features. (25443332)
2014
6
Papillary carcinoma in a thyroglossal duct cyst with concurrent thyroid micro-carcinoma and neck nodal metastases. (24426727)
2013
7
Clinicopathologic characteristics and molecular subtypes of invasive papillary carcinoma of the breast: a large case study. (22932921)
2013
8
Chronic neck hematoma from a papillary carcinoma of the thyroid. (23735604)
2013
9
Anamolous course of right common carotid artery in a case of papillary carcinoma thyroid. (24426411)
2013
10
Solid papillary carcinoma of the breast: a pathologically and clinically distinct breast tumor. (23020734)
2012
11
Intracystic papillary carcinoma of the male breast: a case report and review of the literature. (19588226)
2012
12
Encapsulated papillary carcinoma of the breast: a study of invasion associated markers. (22554960)
2012
13
Intracystic papillary carcinoma: a rare clinical entity. (22273198)
2011
14
Sensitivity of fine-needle aspiration for papillary carcinoma of the thyroid correlates with tumor size. (21695800)
2011
15
Thyroid papillary carcinoma with solid sclerosing change in IgG4-related sclerosing disease. (21951668)
2011
16
A solid thyroid benign nodule that showed a significant decrease in size and ultrasonographic findings mimicking papillary carcinoma during 16-year follow-up. (21099128)
2011
17
Papillary carcinoma arising in a submental-intralingual thyroglossal duct cyst. (21808454)
2010
18
Hyalinizing trabecular tumor and papillary carcinoma of the thyroid. (21034592)
2010
19
Higher sensitivity to patupilone versus paclitaxel chemotherapy in primary uterine serous papillary carcinoma cell lines with high versus low HER-2/neu expression in vitro. (20673976)
2010
20
First description of papillary carcinoma in the thyroid gland of a red-eared slider (Trachemys scripta elegans ). (20159740)
2010
21
Clinical and pathological features of intracystic papillary carcinoma of the breast. (19132460)
2009
22
Outcome of primary papillary carcinoma of thyroglossal duct cyst with local infiltration to soft tissues and uninvolved thyroid. (19346653)
2009
23
Application of CD56, P63 and CK19 immunohistochemistry in the diagnosis of papillary carcinoma of the thyroid. (18254952)
2008
24
Intracystic papillary carcinoma: a review of 917 cases. (18661510)
2008
25
Giant skull metastasis of HA1rthle cell variant of thyroid's papillary carcinoma. (18074106)
2008
26
Loss of myoepithelium is variable in solid papillary carcinoma of the breast. (17927587)
2007
27
Papillary carcinoma of thyroid presenting with skin ulceration. (17635168)
2007
28
Prognosis of patients with benign thyroid diseases accompanied by incidental papillary carcinoma undetectable on preoperative imaging tests. (17571205)
2007
29
Management of menopausal symptoms associated with papillary carcinoma of thyroid. (17000524)
2006
30
MicroRNA deregulation in human thyroid papillary carcinomas. (16728577)
2006
31
Treatment for acute lymphoblastic leukemia in children is associated with papillary carcinoma of thyroid, but not with thyroid disfunction. (17008858)
2006
32
Serous papillary carcinoma of the endometrium arising from endometrial polyps: a clinical, histological, and immunohistochemical study of 13 cases. (16311126)
2005
33
Lymph node spread in stage III or IV primary peritoneal serous papillary carcinoma. (15790449)
2005
34
Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations. (15880523)
2005
35
Intracystic papillary carcinoma of the breast in a male patient diagnosed by core needle biopsy: a case report. (16085239)
2005
36
Thyroid anaplastic carcinoma transformed from papillary carcinoma in extrathyroid area. (15364366)
2004
37
Increased expression of Met protein is associated with up-regulation of hypoxia inducible factor-1 (HIF-1) in tumour cells in papillary carcinoma of the thyroid. (14991901)
2004
38
Thyroglossal duct cyst with papillary carcinoma: what must be done? (15186613)
2004
39
Morphologic spectrum of papillary carcinoma of the thyroid: role of cytology in identifying the variants. (15581164)
2004
40
Effects of therapeutic doses of 131I in thyroid papillary carcinoma patients with elevated thyroglobulin level and negative 131I whole-body scan: comparative study. (12641624)
2003
41
Intraductal papillary carcinoma of bilateral breasts: a case report. (14585566)
2003
42
Value of mesothelial and epithelial antibodies in distinguishing diffuse peritoneal mesothelioma in females from serous papillary carcinoma of the ovary and peritoneum. (11895489)
2002
43
Multiple brown tumors simulating bone metastases: a case of parathyroid adenoma coexisting with papillary carcinoma of the thyroid. (11043714)
2000
44
Expression of inducible nitric oxide synthase in human thyroid papillary carcinomas. (10090309)
1999
45
Papillary carcinoma of the thyroid with exuberant nodular fasciitis-like stroma. (9368667)
1997
46
Marked increases in cathepsin B and L activities distinguish papillary carcinoma of the thyroid from normal thyroid or thyroid with non-neoplastic disease. (8635854)
1996
47
Cytology of thyroglossal cyst papillary carcinoma. (8519199)
1993
48
Low frequency of rearrangements of the ret and trk proto-oncogenes in Japanese thyroid papillary carcinomas. (1381340)
1992
49
PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. (2406025)
1990
50
A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases. (3600795)
1987

Variations for Papillary Carcinoma

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Expression for genes affiliated with Papillary Carcinoma

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Search GEO for disease gene expression data for Papillary Carcinoma.

Pathways for genes affiliated with Papillary Carcinoma

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Compounds for genes affiliated with Papillary Carcinoma

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Compounds related to Papillary Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1pf 04217903 mesylate6110.0MET, HGF
2su 11274619.9MET, HGF
3rubin459.9HGF, IBSP
4pha 665752619.9HGF, MET
5iodine45 2610.7MET, TG, SLC5A5
6ag 1478459.6CCND1, MET, HGF
7perchlorate459.5TG, SLC5A5
8gefitinib45 51 1311.5MET, CCND1, HGF
9strontium ranelate459.5IBSP, CALCA
10iodide45 2610.4TG, FOXE1, NKX2-1, SLC5A5
11sodium iodide459.4NKX2-1, TG, RET, SLC5A5
12hematoxylin459.3IBSP, LGALS3, NKX2-1, KRT1
13isotretinoin45 1310.3KRT1, TG, HGF
14pd 98,059459.2IBSP, MET, CCND1, HGF, RET
1512-o-tetradecanoylphorbol 13-acetate459.2RET, MET, KRT1, HGF
16progesterone45 30 61 26 1313.1CCND1, MET, NKX2-1, LGALS3, KRT1
17hydroxyproline45 26 1311.1CALCA, IBSP, HGF
18genistein45 30 61 3 26 1314.1HGF, MET, RET, TG, CCND1
19111in-pentetreotide459.0CALCA, TG
20retinoid459.0TG, KRT1, HGF, CCND1
21cisplatin45 51 61 1312.0LGALS3, CCND1, MET, TG, HGF
22ly294002459.0CCND1, MET, ANGPT2, RET, HGF
23cycloheximide458.9CCND1, TG, IBSP, HGF, MET
24glycogen45 269.9HGF, CCND1, LGALS3, MET
25ribonucleic acid458.9RET, NKX2-1, MET, ANGPT2, TG
26heparin45 30 26 1311.9MET, LGALS3, HGF, TG, IBSP
27agar458.8HGF, LGALS3, CCND1, TG, RET, MET
28alanine458.7TG, RET, MET, LGALS3, HGF, FOXE1
29wortmannin458.7RET, HGF, CCND1, LGALS3, MET, ANGPT2
30oligonucleotide458.6SLC5A5, LGALS3, MET, RET, IBSP, CCND1
31vitamin d458.6MET, IBSP, LGALS3, HGF, CALCA
32matrigel458.6IBSP, ANGPT2, MET, LGALS3, CCND1, HGF
33steroid458.6CCND1, KRT1, NKX2-1, MET, ANGPT2, IBSP
34threonine458.5IBSP, KRT1, NKX2-1, CCND1, LGALS3, MET
35arginine458.4KRT1, LGALS3, RET, HGF, TG, MET
36lipid458.4LGALS3, IBSP, KRT1, HGF, RET, MET
37thymidine45 269.4HGF, CCND1, MET, IBSP, TG, ANGPT2
38cysteine458.4LGALS3, MET, ANGPT2, RET, TG, IBSP
39pge2458.3CALCA, HGF, MET, ANGPT2, IBSP
40phosphatidylinositol458.3CCND1, MET, IBSP, ANGPT2, RET, LGALS3
41creatinine458.0IBSP, ANGPT2, HGF, CALCA, TG
42glutamate457.8HGF, CALCA, LGALS3, TG, IBSP, KRT1
43testosterone45 61 26 1310.8KRT1, CALCA, HGF, CCND1, MET, RET
44retinoic acid45 268.3TG, RET, ANGPT2, MET, KRT1, CCND1
45calcium45 51 26 1310.1MET, HGF, KRT1, CALCA, IBSP, LGALS3
46paraffin457.0ANGPT2, NKX2-1, IBSP, TG, RET, MET
47vegf457.0CALCA, TG, ANGPT2, RET, MET, LGALS3
48serine457.0RET, KRT1, CCND1, HGF, NKX2-1, MET
49tyrosine456.7RET, IBSP, TG, ANGPT2, LGALS3, HGF
50estrogen456.5IBSP, KRT1, NKX2-1, CALCA, CCND1, LGALS3

GO Terms for genes affiliated with Papillary Carcinoma

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Cellular components related to Papillary Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.4IBSP, TG, ANGPT2, MET, HGF, CALCA
2extracellular spaceGO:00056156.9TG, ANGPT2, LGALS3, HGF, CALCA, KRT1

Biological processes related to Papillary Carcinoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hydrogen peroxide-mediated programmed cell deathGO:0190129910.0HGF, MET
2Leydig cell differentiationGO:003332710.0NKX2-1, CCND1
3myoblast proliferationGO:005145010.0HGF, MET
4regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:00606659.9MET, HGF
5iodide transportGO:00157059.8TG, SLC5A5
6liver developmentGO:00018899.6HGF, CCND1, MET
7thyroid gland developmentGO:00308789.6NKX2-1, FOXE1, TG
8thyroid hormone generationGO:00065909.5SLC5A5, FOXE1, TG
9cellular response to growth factor stimulusGO:00713639.5ANGPT2, IBSP
10positive chemotaxisGO:00509189.4HGF, LGALS3
11organ regenerationGO:00311009.3HGF, CCND1, ANGPT2
12response to painGO:00482659.3RET, CALCA
13monocyte chemotaxisGO:00025489.2CALCA, LGALS3

Molecular functions related to Papillary Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:00420569.7HGF, LGALS3
2protein bindingGO:00055156.0KRT1, RET, ANGPT2, MET, LGALS3, CCND1

Products for genes affiliated with Papillary Carcinoma

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Sources for Papillary Carcinoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet