MCID: PPL002
MIFTS: 59

Papillary Carcinoma malady

Cancer diseases category

Summaries for Papillary Carcinoma

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Papillary thyroid cancer or papillary thyroid carcinoma is the most common type of thyroid cancer,... more...

MalaCards: Papillary Carcinoma, also known as papillary carcinoma nos, is related to thyroiditis and follicular adenoma. An important gene associated with Papillary Carcinoma is MET (met proto-oncogene), and among its related pathways are Thyroid cancer and Development Hedgehog and PTH signaling pathways in bone and cartilage development. The compounds pf 04217903 mesylate and su 11274 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, breast and lymph node, and related mouse phenotypes are endocrine/exocrine gland and no phenotypic analysis.

Disease Ontology:9 A carcinoma that is derived from epithelial cells with finger like projections.

Aliases & Classifications for Papillary Carcinoma

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

papillary carcinoma 9
papillary carcinoma nos 9
carcinoma, papillary 63
carcinoma papillary 46


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Disease Ontology9 DOID:3113
MeSH36 D002291
SNOMED-CT59 25910003, 189562005
NCIt41 C2927

Related Diseases for Papillary Carcinoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Papillary Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.9TG, CALCA
2follicular adenoma31.0LGALS3
3adenoma30.7TG, CCND1, NKX2-1, CALCA, RET, LGALS3
4breast papillary carcinoma30.7ERC1
5papillary thyroid carcinoma30.7TG, RET, MET, LGALS3
6parathyroid adenoma30.6CCND1, LGALS3, RET, CALCA
7struma ovarii30.5TG, NKX2-1
8multinodular goiter30.5CALCA, TG
9graves' disease30.5TG, FOXE1, LGALS3, NKX2-1
10follicular thyroid carcinoma30.5CALCA, TG
11goiter30.4NKX2-1, CALCA, LGALS3, RET, SLC5A5, TG
12hypothyroidism30.4TG, NKX2-1
13endometrial carcinoma30.3NKX2-1, ANGPT2, CCND1
14thyroid cancer30.3NKX2-1, CALCA, TG, RET, MET, LGALS3
15hemangioma30.2RET, NKX2-1, ANGPT2
16teratoma30.2NKX2-1, TG
17primary hyperparathyroidism30.2RET, CALCA, IBSP
18adenoid cystic carcinoma30.0LGALS3, CCND1
19autoimmune thyroiditis30.0TG, CALCA
20congenital hypothyroidism30.0TG, FOXE1, NKX2-1, SLC5A5
21adenocarcinoma29.9CCND1, IBSP, KRT1, MET, NKX2-1, HGF
22mucoepidermoid carcinoma29.9TG, CALCA
23ovarian cancer29.9CCND1, HGF, MET, ANGPT2, IBSP
24melanoma29.8IBSP, MET, HGF, NKX2-1, CCND1, LGALS3
25breast cancer29.7ANGPT2, CCND1, HGF, IBSP, CALCA, MET
26papillary renal cell carcinoma10.6
27peritonitis10.6
28cervicitis10.5
29papilloma10.5
30primary peritoneal serous/papillary carcinoma10.5
31intraductal papilloma10.3
32tall cell variant papillary carcinoma10.3
33papillary transitional carcinoma10.3
34ovary papillary carcinoma10.3
35hyperparathyroidism10.3
36primary peritoneal carcinoma10.3
37gallbladder papillary carcinoma10.2
38columnar cell variant papillary carcinoma10.2
39ductal carcinoma in situ10.2
40metanephric adenoma10.2
41choroiditis10.2
42familial adenomatous polyposis10.2
43kidney pelvis papillary carcinoma10.2
44fasciitis10.2
45leukemia10.2
46mediastinitis10.2
47pancreatitis10.2
48papillary carcinoma of the cervix uteri10.2
49subacute thyroiditis10.1
50papillary serous adenocarcinoma10.1

Graphical network of the top 20 diseases related to Papillary Carcinoma:



Diseases related to papillary carcinoma

Symptoms for Papillary Carcinoma

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Drugs & Therapeutics for Papillary Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Papillary Carcinoma

Drug clinical trials:

Search ClinicalTrials for Papillary Carcinoma

Search NIH Clinical Center for Papillary Carcinoma

Search CenterWatch for Papillary Carcinoma

Genetic Tests for Papillary Carcinoma

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Anatomical Context for Papillary Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Papillary Carcinoma:

34
Thyroid, Breast, Lymph node, Ovary, Kidney, Pancreas, Lung, Bone, Thymus, Brain, B cells, Skin, Colon, Bone marrow, Testis, Prostate, Salivary gland, Liver, Endothelial, Tongue, T cells, Testes, Pituitary, Nk cells

Animal Models for Papillary Carcinoma or affiliated genes

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38MGI
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Publications for Papillary Carcinoma

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53PubMed
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Articles related to Papillary Carcinoma:

(show top 50)    (show all 630)
idTitleAuthorsYear
1
Thyroglossal duct papillary carcinoma in a 15-year old female and review of pediatric cases of thyroglossal duct carcinoma. (24238995)
2014
2
Papillary carcinoma in a thyroglossal duct cyst with concurrent thyroid micro-carcinoma and neck nodal metastases. (24426727)
2013
3
Clinicopathologic characteristics and molecular subtypes of invasive papillary carcinoma of the breast: a large case study. (22932921)
2013
4
Chronic neck hematoma from a papillary carcinoma of the thyroid. (23735604)
2013
5
Anamolous course of right common carotid artery in a case of papillary carcinoma thyroid. (24426411)
2013
6
Solid papillary carcinoma of the breast: a pathologically and clinically distinct breast tumor. (23020734)
2012
7
Intracystic papillary carcinoma of the male breast: a case report and review of the literature. (19588226)
2012
8
Encapsulated papillary carcinoma of the breast: a study of invasion associated markers. (22554960)
2012
9
Intracystic papillary carcinoma: a rare clinical entity. (22273198)
2011
10
Sensitivity of fine-needle aspiration for papillary carcinoma of the thyroid correlates with tumor size. (21695800)
2011
11
Thyroid papillary carcinoma with solid sclerosing change in IgG4-related sclerosing disease. (21951668)
2011
12
A solid thyroid benign nodule that showed a significant decrease in size and ultrasonographic findings mimicking papillary carcinoma during 16-year follow-up. (21099128)
2011
13
Papillary carcinoma arising in a submental-intralingual thyroglossal duct cyst. (21808454)
2010
14
Hyalinizing trabecular tumor and papillary carcinoma of the thyroid. (21034592)
2010
15
Higher sensitivity to patupilone versus paclitaxel chemotherapy in primary uterine serous papillary carcinoma cell lines with high versus low HER-2/neu expression in vitro. (20673976)
2010
16
First description of papillary carcinoma in the thyroid gland of a red-eared slider (Trachemys scripta elegans ). (20159740)
2010
17
Expression of syndecan-1 in papillary carcinoma of the thyroid with extracapsular invasion. (20430252)
2010
18
Invasive papillary carcinoma of male breast. (20090245)
2010
19
Clinical and pathological features of intracystic papillary carcinoma of the breast. (19132460)
2009
20
Outcome of primary papillary carcinoma of thyroglossal duct cyst with local infiltration to soft tissues and uninvolved thyroid. (19346653)
2009
21
Application of CD56, P63 and CK19 immunohistochemistry in the diagnosis of papillary carcinoma of the thyroid. (18254952)
2008
22
Intracystic papillary carcinoma: a review of 917 cases. (18661510)
2008
23
HER-2/neu overexpression and amplification in uterine serous papillary carcinoma: comparative analysis of immunohistochemistry, real-time reverse transcription-polymerase chain reaction, and fluorescence in situ hybridization. (17451461)
2008
24
Loss of myoepithelium is variable in solid papillary carcinoma of the breast. (17927587)
2007
25
Papillary carcinoma of thyroid presenting with skin ulceration. (17635168)
2007
26
Prognosis of patients with benign thyroid diseases accompanied by incidental papillary carcinoma undetectable on preoperative imaging tests. (17571205)
2007
27
Fine needle aspiration cytology of papillary carcinoma of breast. (17573913)
2007
28
Management of menopausal symptoms associated with papillary carcinoma of thyroid. (17000524)
2006
29
MicroRNA deregulation in human thyroid papillary carcinomas. (16728577)
2006
30
Treatment for acute lymphoblastic leukemia in children is associated with papillary carcinoma of thyroid, but not with thyroid disfunction. (17008858)
2006
31
Serous papillary carcinoma of the endometrium arising from endometrial polyps: a clinical, histological, and immunohistochemical study of 13 cases. (16311126)
2005
32
Lymph node spread in stage III or IV primary peritoneal serous papillary carcinoma. (15790449)
2005
33
Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations. (15880523)
2005
34
Intracystic papillary carcinoma of the breast in a male patient diagnosed by core needle biopsy: a case report. (16085239)
2005
35
Thyroid anaplastic carcinoma transformed from papillary carcinoma in extrathyroid area. (15364366)
2004
36
Increased expression of Met protein is associated with up-regulation of hypoxia inducible factor-1 (HIF-1) in tumour cells in papillary carcinoma of the thyroid. (14991901)
2004
37
Thyroglossal duct cyst with papillary carcinoma: what must be done? (15186613)
2004
38
Morphologic spectrum of papillary carcinoma of the thyroid: role of cytology in identifying the variants. (15581164)
2004
39
Effects of therapeutic doses of 131I in thyroid papillary carcinoma patients with elevated thyroglobulin level and negative 131I whole-body scan: comparative study. (12641624)
2003
40
Intraductal papillary carcinoma of bilateral breasts: a case report. (14585566)
2003
41
Value of mesothelial and epithelial antibodies in distinguishing diffuse peritoneal mesothelioma in females from serous papillary carcinoma of the ovary and peritoneum. (11895489)
2002
42
Multiple brown tumors simulating bone metastases: a case of parathyroid adenoma coexisting with papillary carcinoma of the thyroid. (11043714)
2000
43
Expression of inducible nitric oxide synthase in human thyroid papillary carcinomas. (10090309)
1999
44
Papillary carcinoma of the thyroid with exuberant nodular fasciitis-like stroma. (9368667)
1997
45
Marked increases in cathepsin B and L activities distinguish papillary carcinoma of the thyroid from normal thyroid or thyroid with non-neoplastic disease. (8635854)
1996
46
Tall cell variant of papillary thyroid carcinoma: a reassessment and immunohistochemical study with comparison to the usual type of papillary carcinoma of the thyroid. (8712296)
1996
47
Cytology of thyroglossal cyst papillary carcinoma. (8519199)
1993
48
Low frequency of rearrangements of the ret and trk proto-oncogenes in Japanese thyroid papillary carcinomas. (1381340)
1992
49
PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. (2406025)
1990
50
A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases. (3600795)
1987

Variations for Papillary Carcinoma

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Expression for genes affiliated with Papillary Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papillary Carcinoma

Search GEO for disease gene expression data for Papillary Carcinoma.

Pathways for genes affiliated with Papillary Carcinoma

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Sources:
51PathCards, 31KEGG, 61Thomson Reuters, 39NCBI BioSystems Database, 5Cell Signaling Technology, 54QIAGEN
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Compounds for genes affiliated with Papillary Carcinoma

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62Tocris Bioscience, 46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 30IUPHAR, 3BitterDB
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Compounds related to Papillary Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1pf 04217903 mesylate6210.0MET, HGF
2su 11274629.9MET, HGF
3rubin469.9HGF, IBSP
4pha 665752629.9HGF, MET
5iodine46 2510.7MET, TG, SLC5A5
6ag 1478469.6CCND1, MET, HGF
7perchlorate469.5TG, SLC5A5
8gefitinib46 52 1211.5MET, CCND1, HGF
9strontium ranelate469.5IBSP, CALCA
10iodide46 2510.4TG, FOXE1, NKX2-1, SLC5A5
11sodium iodide469.4NKX2-1, TG, RET, SLC5A5
12hematoxylin469.3IBSP, LGALS3, NKX2-1, KRT1
13isotretinoin46 1210.3KRT1, TG, HGF
14pd 98,059469.2IBSP, MET, CCND1, HGF, RET
1512-o-tetradecanoylphorbol 13-acetate469.2RET, MET, KRT1, HGF
16progesterone46 30 62 25 1213.1CCND1, MET, NKX2-1, LGALS3, KRT1
17hydroxyproline46 25 1211.1CALCA, IBSP, HGF
18genistein46 30 62 3 25 1214.1HGF, MET, RET, TG, CCND1
19111in-pentetreotide469.0CALCA, TG
20retinoid469.0TG, KRT1, HGF, CCND1
21cisplatin46 52 62 1212.0LGALS3, CCND1, MET, TG, HGF
22ly294002469.0CCND1, MET, ANGPT2, RET, HGF
23cycloheximide468.9CCND1, TG, IBSP, HGF, MET
24glycogen46 259.9HGF, CCND1, LGALS3, MET
25ribonucleic acid468.9RET, NKX2-1, MET, ANGPT2, TG
26heparin46 30 25 1211.9MET, LGALS3, HGF, TG, IBSP
27agar468.8HGF, LGALS3, CCND1, TG, RET, MET
28alanine468.7TG, RET, MET, LGALS3, HGF, FOXE1
29wortmannin468.7RET, HGF, CCND1, LGALS3, MET, ANGPT2
30oligonucleotide468.6SLC5A5, LGALS3, MET, RET, IBSP, CCND1
31vitamin d468.6MET, IBSP, LGALS3, HGF, CALCA
32matrigel468.6IBSP, ANGPT2, MET, LGALS3, CCND1, HGF
33steroid468.6CCND1, KRT1, NKX2-1, MET, ANGPT2, IBSP
34threonine468.5IBSP, KRT1, NKX2-1, CCND1, LGALS3, MET
35arginine468.4KRT1, LGALS3, RET, HGF, TG, MET
36lipid468.4LGALS3, IBSP, KRT1, HGF, RET, MET
37thymidine46 259.4HGF, CCND1, MET, IBSP, TG, ANGPT2
38cysteine468.4LGALS3, MET, ANGPT2, RET, TG, IBSP
39pge2468.3CALCA, HGF, MET, ANGPT2, IBSP
40phosphatidylinositol468.3CCND1, MET, IBSP, ANGPT2, RET, LGALS3
41creatinine468.0IBSP, ANGPT2, HGF, CALCA, TG
42glutamate467.8HGF, CALCA, LGALS3, TG, IBSP, KRT1
43testosterone46 62 25 1210.8KRT1, CALCA, HGF, CCND1, MET, RET
44retinoic acid46 258.3TG, RET, ANGPT2, MET, KRT1, CCND1
45calcium46 52 25 1210.1MET, HGF, KRT1, CALCA, IBSP, LGALS3
46paraffin467.0ANGPT2, NKX2-1, IBSP, TG, RET, MET
47vegf467.0CALCA, TG, ANGPT2, RET, MET, LGALS3
48serine467.0RET, KRT1, CCND1, HGF, NKX2-1, MET
49tyrosine466.7RET, IBSP, TG, ANGPT2, LGALS3, HGF
50estrogen466.5IBSP, KRT1, NKX2-1, CALCA, CCND1, LGALS3

GO Terms for genes affiliated with Papillary Carcinoma

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17Gene Ontology
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Cellular components related to Papillary Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.4TG, ANGPT2, MET, HGF, CALCA, IBSP
2extracellular spaceGO:0056156.9KRT1, CALCA, HGF, LGALS3, ANGPT2, TG

Biological processes related to Papillary Carcinoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hydrogen peroxide-mediated programmed cell deathGO:190129910.0HGF, MET
2Leydig cell differentiationGO:03332710.0NKX2-1, CCND1
3myoblast proliferationGO:05145010.0HGF, MET
4regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:0606659.9MET, HGF
5iodide transportGO:0157059.8TG, SLC5A5
6liver developmentGO:0018899.6HGF, CCND1, MET
7thyroid gland developmentGO:0308789.6NKX2-1, FOXE1, TG
8thyroid hormone generationGO:0065909.5SLC5A5, FOXE1, TG
9cellular response to growth factor stimulusGO:0713639.5ANGPT2, IBSP
10positive chemotaxisGO:0509189.4HGF, LGALS3
11organ regenerationGO:0311009.3HGF, CCND1, ANGPT2
12response to painGO:0482659.3RET, CALCA
13monocyte chemotaxisGO:0025489.2CALCA, LGALS3

Molecular functions related to Papillary Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:0420569.7HGF, LGALS3
2protein bindingGO:0055156.0KRT1, RET, ANGPT2, MET, LGALS3, CCND1

Products for genes affiliated with Papillary Carcinoma

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Sources for Papillary Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet