MCID: PPL002
MIFTS: 61

Papillary Carcinoma malady

Cancer diseases category

Summaries for Papillary Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Papillary thyroid cancer or papillary thyroid carcinoma is the most common type of thyroid cancer,... more...

MalaCards: Papillary Carcinoma, also known as papillary carcinoma nos, is related to papillary thyroid carcinoma and thyroiditis. An important gene associated with Papillary Carcinoma is MET (met proto-oncogene), and among its related pathways are GPCR Pathway and Focal Adhesion. The compounds paraffin and vegf have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and breast, and related mouse phenotypes are mortality/aging and cardiovascular system.

Disease Ontology:8 A carcinoma that is derived from epithelial cells with finger like projections.

Aliases & Classifications for Papillary Carcinoma

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

papillary carcinoma 8
papillary carcinoma nos 8
carcinoma, papillary 60
carcinoma papillary 44


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Disease Ontology8 DOID:3113
MeSH34 D002291
SNOMED-CT56 25910003, 189562005
NCIt39 C2927

Related Diseases for Papillary Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Papillary Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1papillary thyroid carcinoma31.8ERC1
2thyroiditis31.8CALCA, TG
3breast papillary carcinoma31.3ERC1
4follicular thyroid carcinoma31.0CALCA, TG
5adenoma31.0CT49, TG, TFF3, MET, NKX2-1, RET
6thyroid medullary carcinoma30.8BRAF, CALCA, NKX2-1, RET, LGALS3, TG
7follicular adenoma30.7LGALS3, KRT19
8papilloma30.6CT49
9bladder carcinoma30.6SERPINB5, KRT19, CT49, CCND1
10parathyroid carcinoma30.5CCND1, RET
11thyroid cancer30.5CCDC6, BRAF, CALCA, MET, NKX2-1, RET
12goiter30.5RET, LGALS3, TG, NKX2-1, BRAF, CALCA
13parathyroid adenoma30.5LGALS3, RET, CALCA, CCND1
14endometrial carcinoma30.5CCND1, BRAF, NKX2-1
15graves' disease30.4TG, LGALS3, NKX2-1, CT49, FOXE1
16multinodular goiter30.4TG, KRT19, CALCA
17squamous cell carcinoma30.4CCND1, KRT19, LGALS3
18struma ovarii30.3NKX2-1, TG
19hyperparathyroidism30.3RET, CALCA
20ovarian cancer30.2CCND1, BRAF, MET, NKX2-1, SERPINB5
21neuroendocrine carcinoma30.2CALCA, NKX2-1, KRT19
22hypothyroidism30.2FOXE1, NKX2-1, TG
23adenocarcinoma30.1HGF, CCND1, BRAF, CT49, TFF3, MET
24congenital hypothyroidism30.1TG, NKX2-1, FOXE1
25meningioma30.1CT49, S100A1
26osteosarcoma30.1MET, CT49
27hepatitis30.1HGF
28hemangioma30.1NKX2-1, RET
29melanoma29.9S100A1, BRAF, CCND1, HGF, CT49, MET
30lung adenocarcinoma29.9HGF, CCND1, BRAF, MET, NKX2-1, KRT19
31adenoid cystic carcinoma29.9CCND1, S100A1, KRT19, LGALS3, SERPINB5
32astrocytoma29.9LGALS3, MET, CT49
33breast cancer29.9CCND1, CT49, MMP11, SERPINB5
34mucoepidermoid carcinoma29.9TG, S100A1, CALCA
35laryngeal squamous cell carcinoma29.9CCND1, KRT19
36renal clear cell carcinoma29.9MET, S100A1
37autoimmune thyroiditis29.9CALCA, TG
38leiomyosarcoma29.9S100A1
39hyperthyroidism29.9TG
40neurofibroma29.9S100A1, MET
41thymoma29.9NKX2-1
42hypercalcemia29.8CALCA
43papillary adenoma10.6
44peritonitis10.6
45cervicitis10.5
46tall cell variant papillary carcinoma10.4
47ovary papillary carcinoma10.4
48papillary squamous carcinoma10.4
49in situ carcinoma10.4
50gallbladder papillary carcinoma10.3

Graphical network of the top 20 diseases related to Papillary Carcinoma:



Diseases related to papillary carcinoma

Clinical Features for Papillary Carcinoma

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Drugs & Therapeutics for Papillary Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Papillary Carcinoma

Genetic Tests for Papillary Carcinoma

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Anatomical Context for Papillary Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Papillary Carcinoma:

32
Thyroid, Lymph node, Breast, Kidney, Pancreas, Endothelial, Lung, Ovary, Bone, Pituitary, Cervix, Brain, Colon, Testes, Thymus, Skin, Liver, B cells, Heart, Salivary gland, Trachea, Bone marrow, Testis, Uterus, Prostate, Monocytes, T cells, Tongue, Small intestine, Smooth muscle, Nk cells

Animal Models for Papillary Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Papillary Carcinoma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.4FOXE1, CALCA, BRAF, CCND1, HGF, PPRC1
2MP:000538511.3LGALS3, HGF, CCND1, BRAF, CALCA, S100A1
3MP:000538111.2CCND1, BRAF, FOXE1, TFF3, MET, NKX2-1
4MP:000200611.1CCND1, BRAF, CALCA, MET, NKX2-1, RET
5MP:000537911.1CCND1, BRAF, FOXE1, MET, NKX2-1, RET
6MP:000538011.0HGF, BRAF, CALCA, PPRC1, MET, RET
7MP:000287311.0CCND1, BRAF, CALCA, S100A1, MET, RET
8MP:000538411.0CCND1, BRAF, MET, NKX2-1, RET, KRT19
9MP:000537610.9CALCA, FOXE1, TFF3, RET, MMP11, TG
10MP:000363110.9CCND1, BRAF, CALCA, MET, NKX2-1, RET
11MP:000538810.6CCND1, MET, LGALS3
12MP:000301210.5HGF, MET, NKX2-1, RET, KRT19, ERC1

Publications for Papillary Carcinoma

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50PubMed
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Articles related to Papillary Carcinoma:

(show top 50)    (show all 2237)
idTitleAuthorsYear
1
Extranodal extension of metastatic papillary thyroid carcinoma: correlation with biochemical endpoints, nodal persistence, and systemic disease progression. (23421588)
2013
2
Gastrointestinal stromal tumor of small intestine and synchronous bilateral papillary renal cell carcinoma. (24195178)
2013
3
Predictive factors for different subgroups of central lymph node metastasis in unilateral papillary thyroid carcinoma. (24107609)
2013
4
Fine-needle aspiration of metastatic papillary thyroid carcinoma found in the liver. (22362717)
2013
5
Papillary carcinoma of the duodenum combined with right renal carcinoma: a case report. (23375073)
2013
6
Nodal status of central lymph nodes as a negative prognostic factor for papillary thyroid carcinoma. (23640873)
2013
7
In papillary thyroid carcinoma, TIMP-1 expression correlates with BRAF (V600E) mutation status and together with hypoxia-related proteins predicts aggressive behavior. (23893334)
2013
8
Breast Carcinoma With Tubulopapillary Features: A Variant of Papillary Carcinoma With a Stronger Correlation With Predictors of Adverse Prognosis. (24008438)
2013
9
Matrix metalloproteinase-9 and the Cu/Zn ratio as ancillary diagnostic tools in distinguishing between the classical and follicular variants of papillary thyroid carcinoma. (22528774)
2012
10
Benign ovarian serous cystadenoma mimicking papillary thyroid carcinoma metastasis on I-131 SPECT/CT. (22474878)
2012
11
Optimal surgical extent of lateral and central neck dissection for papillary thyroid carcinoma located in one lobe with clinical lateral lymph node metastasis. (23098385)
2012
12
Papillary thyroid carcinoma in pregnancy: a variant of the disease? (22875646)
2012
13
Thyroid papillary carcinoma with solid sclerosing change in IgG4-related sclerosing disease. (21951668)
2011
14
Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2. (22014567)
2011
15
Novel FH mutations in families with hereditary leiomyomatosis and renal cell cancer (HLRCC) and patients with isolated type 2 papillary renal cell carcinoma. (21398687)
2011
16
An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma. (22014576)
2011
17
Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma. (21509594)
2011
18
XRCC1 polymorphisms and risk of papillary thyroid carcinoma in a Korean sample. (21860547)
2011
19
Papillary carcinoma arising in a submental-intralingual thyroglossal duct cyst. (21808454)
2010
20
Detectable BRAF mutation in serum DNA samples from patients with papillary thyroid carcinomas. (19626635)
2010
21
Differential sensitivity to platinum-based chemotherapy in primary uterine serous papillary carcinoma cell lines with high vs low HER-2/neu expression in vitro. (20417484)
2010
22
Phosphorylated c-Jun NH2-terminal kinase is overexpressed in human papillary thyroid carcinomas and associates with lymph node metastasis. (20138424)
2010
23
Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy. (20797751)
2010
24
RET/PTC rearrangements arising from a small population of papillary thyroid carcinoma cells, possible candidate for passenger mutation. (19495791)
2009
25
Papillary carcinoma in a supra hyoid thyroglossal duct cyst - an unusual presentation. (23120611)
2009
26
Association of genetic polymorphisms and haplotypes in hMLH1 and hMSH3 gene with the risk of papillary thyroid carcinoma]. (18683134)
2008
27
Clear cell papillary renal cell carcinoma: a distinct histopathologic and molecular genetic entity. (18594469)
2008
28
Trisomy 17 as a marker for a subset of noninvasive thyroid nodules with focal features of papillary carcinoma: cytogenetic and molecular analysis of 62 cases and correlation with histological findings. (17956956)
2008
29
Papillary carcinoma of thyroid presenting with skin ulceration. (17635168)
2007
30
Investigation of V600E BRAF mutation in papillary thyroid carcinoma in the Polish population. (17693984)
2007
31
A rare case of hyperfunctioning papillary carcinoma of the thyroid gland. (17453446)
2007
32
Choroid plexus papillary carcinoma associated with hemorrhage. A case report. (24351264)
2006
33
Thyroid-stimulating hormone-stimulated fused positron emission tomography/computed tomography in the evaluation of recurrence in 131I-negative papillary thyroid carcinoma. (16571089)
2006
34
Lithium-associated hypothyroidism and thyroid papillary carcinoma: a case report. (16553102)
2006
35
De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor origin. (16564925)
2006
36
25-hydroxyvitamin D3 1alpha-hydroxylase and vitamin D receptor expression in papillary thyroid carcinoma. (16314444)
2006
37
Papillary urothelial bladder carcinoma associated with osteoclast-like giant cells. (16132761)
2005
38
ret/PTC and BRAF act as distinct molecular, time-dependant triggers in a sporadic Irish cohort of papillary thyroid carcinoma. (15735849)
2005
39
Investigation of BRAF mutation in a series of papillary thyroid carcinoma and matched-lymph node metastasis reveals a new mutation in metastasis. (15807885)
2005
40
High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma. (15817909)
2005
41
Gene profiling reveals specific oncogenic mechanisms and signaling pathways in oncocytic and papillary thyroid carcinoma. (15806164)
2005
42
Amiodarone-induced hyperthyroidism in a patient with functioning papillary carcinoma of the thyroid and extensive hepatic metastases. (16405405)
2005
43
Differentiation of renal clear cell carcinoma and renal papillary carcinoma using quantitative CT enhancement parameters. (15505308)
2004
44
High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. (12907632)
2003
45
Cytokeratin 19 immunoreactivity in the diagnosis of papillary thyroid carcinoma: a note of caution. (11710686)
2001
46
BRCA1-related papillary serous carcinoma of the peritoneum has a unique molecular pathogenesis. (10728699)
2000
47
NTRK1 re-arrangement in papillary thyroid carcinomas of children after the Chernobyl reactor accident. (10074915)
1999
48
Simultaneous occurrence of a medullary and a papillary thyroid carcinoma in the same patient. (9228264)
1997
49
Intercellular adhesion molecule-1 (ICAM-1) immunoreactivity in well-differentiated thyroid papillary carcinomas. (8821957)
1996
50
Estrogen-receptor protein in thyroid neoplasms. An immunohistochemical analysis of papillary carcinoma, follicular carcinoma, and follicular adenoma. (1768209)
1991

Genetic Variations for Papillary Carcinoma

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Expression for genes affiliated with Papillary Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papillary Carcinoma

Search GEO for disease gene expression data for Papillary Carcinoma.

Pathways for genes affiliated with Papillary Carcinoma

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51QIAGEN, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Papillary Carcinoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Papillary Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1paraffin4411.7TG, HGF, CCND1, BRAF, S100A1, CT49
2vegf4411.6CT49, CALCA, BRAF, CCND1, HGF, TFF3
3tyrosine4411.6S100A1, BRAF, CCDC6, CCND1, HGF, TFF3
4retinoic acid44 2412.6CT49, S100A1, BRAF, CCND1, HGF, MET
5progesterone44 59 28 11 2415.5CCND1, BRAF, S100A1, CT49, TFF3, MET
6testosterone44 59 11 2414.4HGF, CCND1, CALCA, CT49, MET, RET
7agar4411.4HGF, CCND1, BRAF, CT49, MET, RET
8cisplatin44 49 59 1114.3HGF, CCND1, BRAF, MET, KRT19, LGALS3
9oligonucleotide4411.3CCND1, BRAF, CT49, MET, NKX2-1, RET
10steroid4411.3CCND1, CT49, TFF3, MET, NKX2-1, MMP11
11alanine4411.3HGF, BRAF, FOXE1, CT49, MET, RET
12matrigel4411.3HGF, CCND1, BRAF, MET, KRT19, LGALS3
13cysteine4411.3S100A1, CT49, TFF3, MET, RET, MMP11
14glycogen44 2412.3HGF, CCND1, S100A1, TFF3, MET, KRT19
15phosphatidylinositol4411.2HGF, CCND1, BRAF, TFF3, MET, RET
16wortmannin4411.2HGF, CCND1, BRAF, MET, RET, LGALS3
17pd 98,0594411.2HGF, CCND1, BRAF, TFF3, MET, RET
18phosphoinositide4411.2HGF, CCND1, BRAF, TFF3, MET, LGALS3
19serine4411.2CCND1, CT49, NKX2-1, RET, KRT19
20thymidine44 2412.2HGF, CCND1, CT49, MET, KRT19, TG
21atp44 2812.2HGF, BRAF, CT49, MET, RET, KRT19
22calcium44 49 11 2414.2HGF, BRAF, CALCA, S100A1, MET, RET
23sodium iodide4411.1BRAF, NKX2-1, RET, TG
24ribonucleic acid4411.1MET, NKX2-1, RET, KRT19, TG
25iodide44 2412.1BRAF, FOXE1, NKX2-1, TG
2612-o-tetradecanoylphorbol 13-acetate4411.1HGF, BRAF, MET, RET, MMP11
27hematoxylin4411.1S100A1, NKX2-1, KRT19, LGALS3
28ly2940024411.1RET, MET, BRAF, CCND1, HGF
29geldanamycin44 49 59 1114.1HGF, CCND1, BRAF, MET
30depsipeptide4411.0CCND1, SERPINB5, TG
31arginine4411.0HGF, BRAF, MET, RET, LGALS3, TG
32p0024411.0SERPINB5, KRT19, MET, BRAF
33genistein44 28 59 2 11 2416.0HGF, CCND1, MET, RET, TG
34iodine44 2412.0TG, MET, BRAF
35formaldehyde44 2412.0LGALS3, KRT19, NKX2-1, CCND1
36estrogen4411.0TG
37imatinib44 49 1113.0HGF, CCND1, BRAF, RET
38b 7234411.0KRT19, NKX2-1, S100A1
39crcs4410.9CCND1, BRAF, MET
40adriamycin4410.9HGF, CCND1
41sorafenib44 49 1112.9CCND1, BRAF, RET
42Cabozantinib1110.8RET, MET
43lactate4410.8HGF, CALCA, KRT19, LGALS3, TG
44nitric oxide44 11 2412.8CALCA, S100A1, TFF3, MET, LGALS3, SERPINB5
45pf 04217903 mesylate5910.8HGF, MET
46su 112745910.7HGF, MET
47threonine4410.7CCND1, BRAF, MET, NKX2-1, RET, LGALS3
48pha 6657525910.7HGF, MET
49crizotinib49 5911.6MET, HGF
50aspirin44 49 28 2413.4SERPINB5, LGALS3, TFF3, HGF

GO Terms for genes affiliated with Papillary Carcinoma

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16Gene Ontology
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Biological processes related to Papillary Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:03087810.8TG, NKX2-1, FOXE1
2negative regulation of hydrogen peroxide-mediated programmed cell deathGO:190129910.7HGF, MET
3myoblast proliferationGO:05145010.7HGF, MET
4regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:06066510.6HGF, MET
5thyroid hormone generationGO:00659010.6FOXE1, TG
6liver developmentGO:00188910.5MET, HGF, CCND1
7Leydig cell differentiationGO:03332710.3CCND1, NKX2-1

Molecular functions related to Papillary Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.9SERPINB5, HGF, CCND1, CCDC6, BRAF, CALCA
2protein complex bindingGO:03240310.6KRT19, CALCA, CCND1

Products for genes affiliated with Papillary Carcinoma

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Sources for Papillary Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet