Papillary Carcinoma malady

Wikipedia: Papillary thyroid cancer or papillary thyroid carcinoma is the most common type of thyroid cancer,...⁴⁴ more...

MalaCards: Papillary Carcinoma, also known as papillary carcinoma nos (morphologic abnormality), is related to squamous cell carcinoma and prostate carcinoma. An important gene associated with Papillary Carcinoma is CCDC6 (coiled-coil domain containing 6), and among its related pathways are GPCR Pathway and Endothelin-1 Signaling Pathway. The drugs carmustine and diethylstilbestrol diphosphate and the compounds atp and pd 98,059 have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and thymus, and related mouse phenotypes are muscle and mortality/aging.

Disease Ontology: A carcinoma that is derived from epithelial cells with finger like projections.⁶

Aliases & Descriptions:

papillary carcinoma 6 8 papillary carcinoma nos (morphologic abnormality) 6 papillary carcinoma (morphologic abnormality) 6

carcinoma, papillary 43 carcinoma papillary 32 carcinoma 43

Diseases related to papillary carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1631)

id	Related Disease	Score	Top Affiliating Genes
1	squamous cell carcinoma	42.2	LGALS3, CD44, CDH1, MMP7, MKI67, CCND1
2	prostate carcinoma	37.4	BRCA2, VEGFA, CD82, CDH1, CAV1, ERBB2
3	basal cell carcinoma	36.8	RARA, BCL2, LGALS3, BAX, CD44, MMP11
4	neuroendocrine carcinoma	35.6	NCAM1, KIT, CHGA, MUC1, CEACAM5, CDH1
5	merkel cell carcinoma	35.1	NCAM1, KIT, CHGA, MUC1, MAPK10, KRT8
6	adenoid cystic carcinoma	34.7	NCAM1, KIT, PCNA, SERPINB5, VIM, RASSF1
7	familial medullary thyroid carcinoma	34.3	RET, FOS, CALCA, STAT3
8	papillary thyroid carcinoma	34.0	NCOA4, PCM1, GOLGA5, TRIM24, TRIM33
9	adrenocortical carcinoma	33.9	CHGA, MKI67, CALB2, TP53, SMAD4, SYP
10	liver cirrhosis	33.8	NCAM1, RAF1, RASSF1, FOS, ANGPT2, ALPP
11	mucoepidermoid carcinoma	33.7	PCNA, CHGA, MUC1, MUC4, S100A1, CEACAM5
12	parathyroid carcinoma	32.7	RET, RB1, BRCA2, LGALS3, MKI67, MEN1
13	adenosquamous carcinoma	32.6	CHGA, MUC1, MUC4, CEACAM5, TP63, PTHLH
14	large cell carcinoma	32.5	CHGA, CEACAM5, HRAS, ERBB2, TP63, PTHLH
15	collecting duct carcinoma	32.3	VIM, VHL, PBRM1, MUC1, CDKN1B, FLCN
16	clear cell renal cell carcinoma	32.2	KIT, VIM, VHL, VEGFA, VEGFC, RAF1
17	acinar cell carcinoma	32.2	CHGA, CEACAM5, APC, CTNNB1, SMAD4, SYP
18	squamous cell carcinoma of the head and neck	32.2	RB1, VEGFA, VEGFC, RARA, RARB, RASSF1
19	pancreatic ductal carcinoma	32.2	CHGA, SMAD4, KRT8, KRT7, KRT20
20	multiple endocrine neoplasia	32.1	RET, BRCA1, BRCA2, VHL, CHGA, CDKN1B
21	bronchogenic carcinoma	32.1	CEACAM5, CDKN2A, TP53, KRT19, TG, PSG2
22	chromophobe renal cell carcinoma	32.1	KIT, PCNA, VIM, VHL, RARB, PBRM1
23	multiple endocrine neoplasia type 2a	32.0	RET, VHL, MEN1, CALCA, NRP1
24	hypercalcemia	32.0	VIM, CHGA, FGF2, MEN1, IL6, CCND1
25	follicular adenoma	31.8	RET, RAP1A, BIRC5, LGALS3, S100A4, MKI67
26	pleomorphic adenoma	31.7	PCNA, SERPINB5, VIM, MUC1, S100A1, CDKN1B
27	pleomorphic carcinoma	31.5	VIM, MUC1, CDKN1B, CALB2, CAV1, TP53
28	skin carcinoma	31.4	CHGA, CDH1, TP53, KRT8, THBS1
29	non-small cell lung carcinoma	31.4	NCAM1, PCNA, RB1, BRAF, VEGFA, VEGFC
30	bile duct carcinoma	31.3	KIT, VEGFC, BCL2, MUC1, MUC4, CDKN2A
31	papillary serous adenocarcinoma	31.3	MUC16, ERBB2, KRT7, KRT20, NKX2-1, PGR
32	cervix carcinoma	31.2	CDKN2A, CD44, MKI67, MET, ERBB2, TP53
33	neuroendocrine tumor	31.1	NCAM1, RET, RAF1, RASSF1, PAX8, CHGA
34	stomach carcinoma	31.0	RASSF1, CHGA, CEACAM5, CDKN2A, CD44, CDH1
35	lymphoepithelioma-like carcinoma	31.0	VIM, BCL2, MUC1, CDH1, ALPP, TP53
36	hepatocellular carcinoma (fibrolamellar variant)	31.0	MET, PLAU, PLAUR, HGF
37	adrenal cortical carcinoma	31.0	VIM, MUC1, TP53, ACTC1, NKX2-1
38	thyroid cancer	31.0	RET, SERPINB5, BRAF, PAX8, LGALS3, S100A4
39	basaloid squamous cell carcinoma	31.0	PCNA, BIRC5, BCL2L1, BAX, S100A1, CDKN1B
40	renal clear cell carcinoma	30.9	VIM, VHL, VEGFA, RASSF1, BIRC5, BCL2
41	small cell carcinoma	30.9	NCAM1, KIT, PCNA, RB1, VIM, BRCA1
42	pulmonary large cell neuroendocrine carcinoma	30.9	CDKN2A, TP63, KRT8, KRT7, KRT19, NKX2-1
43	ulcerative colitis	30.8	CD86, CD80, CD83, MMP7, FOS, IL6
44	papillary renal cell carcinoma	30.7	KIT, PCNA, VHL, VEGFA, VEGFC, RASSF1
45	inflammatory breast carcinoma	30.7	CDH1, MET, ESR1, ERBB2, TFF1
46	cervical squamous cell carcinoma	30.7	RAP1A, RASSF1, BIRC5, BCL2, MUC1, BAX
47	fallopian tube carcinoma	30.7	BRCA1, BRCA2, ERBB2
48	pleomorphic adenoma carcinoma	30.6	CDKN2A, CCND1, ERBB2, TP53, TP63, CTNNB1
49	verrucous carcinoma	30.6	PCNA, RB1, CDKN2A, CD44, CDH1, CCND1
50	prostate small cell carcinoma	30.6	NCAM1, CHGA, CD44, CALCA

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, nilutamide

MalaCards organs/tissues related to papillary carcinoma:

²²

MGI Mouse Phenotypes related to papillary carcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle phenotype	MP:0005369	INF	RET, KIT, RB1, RBL1, VIM, BRAF
2	mortality/aging	MP:0010768	INF	NCAM1, RET, SFN, RB1, RBL1,
3	skeleton phenotype	MP:0005390	INF	KIT, SFN, RB1, RBL1, BRAF, BRCA1
4	tumorigenesis	MP:0002006	INF	RET, KIT, SFN, RB1, RBL1, BRAF
5	nervous system phenotype	MP:0003631	INF	KIT, RB1, RBL1, BRAF, BRCA1,
6	immune system phenotype	MP:0005387	INF	KIT, SFN, RBL1, VIM, BRAF, BRCA1
7	vision/eye phenotype	MP:0005391	INF	NCAM1, KIT, SFN, RB1, RBL1, VIM
8	reproductive system phenotype	MP:0005389	INF	RET, SFN, RBL1, BRCA1, BRCA2,
9	renal/urinary system phenotype	MP:0005367	INF	RET, KIT, BRAF, BRCA1, , RARA
10	pigmentation phenotype	MP:0001186	INF	KIT, RB1, BRAF, BRCA1, PAX2, BCL2
11	embryogenesis phenotype	MP:0005380	INF	RET, KIT, SFN, RBL1, , VIM
12	integument phenotype	MP:0010771	INF	KIT, SFN, RB1, RBL1, BRAF, BRCA1
13	normal phenotype	MP:0002873	INF	RET, RBL1, BRAF, BRCA1, BRCA2,
14	hearing/vestibular/ear phenotype	MP:0005377	INF	KIT, SFN, RB1, RARA, RARB,
15	endocrine/exocrine gland phenotype	MP:0005379	INF	RET, SFN, RBL1, BRCA1, BRCA2,
16	growth/size phenotype	MP:0005378	INF	RET, KIT, SFN, RB1, RBL1, BRAF
17	hematopoietic system phenotype	MP:0005397	INF	KIT, SFN, PCNA, RBL1, BRAF, BRCA1
18	cardiovascular system phenotype	MP:0005385	INF	RET, KIT, RB1, RBL1, VIM, BRAF
19	respiratory system phenotype	MP:0005388	INF	RET, BRCA1, , FUT8, CALCA, TP63
20	limbs/digits/tail phenotype	MP:0005371	INF	RET, KIT, SFN, RB1, RBL1, BRCA1
21	liver/biliary system phenotype	MP:0005370	INF	KIT, SFN, RBL1, , VEGFA, MEN1
22	digestive/alimentary phenotype	MP:0005381	INF	RET, KIT, SFN, RB1, RBL1, BRAF
23	craniofacial phenotype	MP:0005382	INF	KIT, RBL1, , , FGFR2, MEN1
24	behavior/neurological phenotype	MP:0005386	INF	NCAM1, KIT, RB1, RBL1, VIM, BRAF
25	no phenotypic analysis	MP:0003012	INF	RET, PCNA, RB1, RBL1, VEGFA,
26	cellular phenotype	MP:0005384	INF	NCAM1, RET, KIT, SFN, PCNA, RB1
27	adipose tissue phenotype	MP:0005375	INF	RB1, RBL1, BRAF, BRCA1, BCL2, CDKN1B
28	homeostasis/metabolism phenotype	MP:0005376	INF	RET, KIT, RB1, RBL1, VIM, BRAF
29	other phenotype	MP:0005395	INF	RARA, RARB, CDKN2A, , CAV1,

Articles related to papillary carcinoma:

(show top 50)    (show all 174)

id	Title	Authors	Year	Affiliating Genes
1	Expression and distribution of S-100, CD83, and costi mulatory molecules (CD80 and CD86) in tissues of thyroid papillary carcinoma. (21469977)	Xu W.C.... Chen S.R.	2011	CD86, CD80, CD83
2	COX-2 is induced by HGF stimulation in Met-positive t hyroid papillary carcinoma cells and is involved in tumour invasiveness. (19391129)	Scarpino S.... Ruco L.	2009	HGF
3	Papillary carcinoma of the breast lacks evidence of R ET rearrangements despite morphological similarities to papillary thyroid carci noma. (19543246)	Hameed O.... Pfeifer J.D.	2009	RET
4	Papillary carcinoma with nodular fasciitis-like stroma--a case report in pregnancy. (18232002)	Leal I.I.... de Castro Montenegro F.S.	2008	NKX2-1
5	Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid: a meta-analysis. (17520704)	Lee J.H.... Kim Y.S.	2007	BRAF
6	Overexpression of claudin-3 and claudin-4 receptors in uterine serous papillary carcinoma: novel targets for a type-specific therapy using Clostridium perfringens enterotoxin (CPE). (17326053)	Santin A.D.... Pecorelli S.	2007	CLDN4, CLDN3
7	Evaluation of p53 nuclear accumulation in low- and high-grade (WHO/ISUP classification) transitional papillary carcinomas of the bladder for tumor recurrence and progression. (16825812)	Vardar E.... Ayder A.R.	2006	TP53
8	Quantitation of thyroid peroxidase mRNA in peripheral blood for early detection of thyroid papillary carcinoma. (16756464)	Ishikawa T.... Uchida K.	2006	TPO, TSHR
9	Thyroid transcription factor 1 (TTF-1) and p63 expression in two primary thyroid papillary carcinomas of branchial cleft cysts. (16628413)	Lanzafame S.... Cappellani A.	2006	TP63, HNF1A, NKX2-1
10	Differential expression of the components of the plasminogen activating system in human thyroid tumour derived cell lines and papillary carcinomas. (16928445)	Ulisse S.... D'Armiento M.	2006	PLAU, PLAUR
11	GLUT1 and p63 expression in endometrial intraepithelial and uterine serous papillary carcinoma. (16842248)	Idrees M.T.... Burstein D.E.	2006	TP53, SLC2A1, TP63
12	Overexpression of kallikrein 10 (hK10) in uterine serous papillary carcinomas. (16647913)	Santin A.D.... Pecorelli S.	2006	KLK10
13	The role of cytokeratin 19 in the differential diagnosis of true papillary carcinoma of thyroid and papillary carcinoma-like changes in Graves' disease. (16000848)	ErkiliAs S.... KoAser N.E.	2005	KRT19
14	Benign HA1rthle cell adenoma with papillary architecture: a benign lesion mimicking oncocytic papillary carcinoma. (15735853)	Mai K.T.... Stinson W.A.	2005	LGALS3
15	Determination of HER2/neu status in uterine serous papillary carcinoma: Comparative analysis of immunohistochemistry and fluorescence in situ hybridization. (15894362)	Santin A.D.... Pecorelli S.	2005	ERBB2
16	Reply to: Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas. (16253771)	Lima J.... Sobrinho-SimA/es M.	2005	BRAF
17	Hepatocyte growth factor (HGF) downregulates thrombospondin 1 (TSP-1) expression in thyroid papillary carcinoma cells. (15526350)	Scarpino S.... Ruco L.P.	2005	MET, HGF, THBS1
18	Induction of thyroid papillary carcinoma cell prolife ration by estrogen is associated with an altered expression of Bcl-xL. (15969986)	Lee M.L.... van Hasselt C.A.	2005	BCL2L1
19	Does a Leu 512 Arg thyrotropin receptor mutation cause an autonomously functioning papillary carcinoma? (15671779)	Gozu H.... Cirakoglu B.	2004	TSHR
20	Commenting on 'HER2/neu overexpression: has the Achilles' heel of uterine serous papillary carcinoma been exposed? (88:263-5) by Santin AD'. (14751194)	Slomovitz B.M.... Lu K.H.	2004	ERBB2
21	Molecular profiling distinguishes papillary carcinoma from benign thyroid nodules. (15240595)	Finley D.J.... Fahey T.J.	2004	LGALS3
22	Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas. (15145515)	Nikiforova M.N.... Nikiforov Y.E.	2004	BRAF
23	Immunohistochemical detection of p53 homolog p63 in solid cell nests, papillary thyroid carcinoma, and hashimoto's thyroiditis: A stem cell hypothesis of papillary carcinoma oncogenesis. (15116328)	Burstein D.E.... Unger P.	2004	TP63
24	BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. (14602780)	Nikiforova M.N.... Nikiforov Y.E.	2003	BRAF
25	Cytokeratin subtypes in thyroid tumours: immunohistochemical study with emphasis on the follicular variant of papillary carcinoma. (14974863)	Cameron B.R.... Berean K.W.	2003	KRT19, KRT20
26	Effects of therapeutic doses of 131I in thyroid papillary carcinoma patients with elevated thyroglobulin level and negative 131I whole-body scan: comparative study. (12641624)	Koh J.M.... Shong Y.K.	2003	TG
27	Inverse correlation between heparan sulfate composition and heparanase-1 gene expression in thyroid papillary carcinomas: a potential role in tumor metastasis. (14676122)	Xu X.... Prinz R.A.	2003	HPSE
28	Role of galectin-3 immunodetection in the cytological diagnosis of thyroid cystic papillary carcinoma. (12370115)	Papotti M.... Orlandi F.	2002	LGALS3
29	Invasive papillary carcinomas of the extrahepatic bile ducts: a clinicopathologic and immunohistochemical study of 13 cases. (12481004)	Hoang M.P.... Albores-Saavedra J.	2002	SMAD4
30	Assessment of RET/PTC oncogene activation and clonality in thyroid nodules with incomplete morphological evidence of papillary carcinoma: a search for the early precursors of papillary cancer. (12057919)	Fusco A.... Tallini G.	2002	RET
31	Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells. (11251175)	Yoshii T.... Kubo T.	2001	LGALS3
32	Comparative immunohistochemical study of endometrioid and serous papillary carcinoma of endometrium. (11446475)	Halperin R.... Schneider D.	2001	ERBB2, TP53, PGR
33	Tumor-to-tumor metastasis to follicular variant of papillary carcinoma of thyroid. (10420227)	Baloch Z.W.... LiVolsi V.A.	1999	CALCA, KRT19, TG
34	Cyclin D1 expression as a prognostic parameter in papillary carcinoma of the thyroid. (9949353)	Muro-Cacho C.A.... Futran N.	1999	CCND1
35	Hepatocyte growth factor (HGF) stimulates tumour invasiveness in papillary carcinoma of the thyroid. (10629560)	Scarpino S.... Ruco L.P.	1999	HGF
36	Is uterine serous papillary carcinoma a BRCA1-related disease? Case report and review of the literature. (10525392)	Hornreich G.... Levy-Lahad E.	1999	BRCA1
37	High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant. (10566678)	Thomas G.A.... Vecchio G.	1999	RET
38	Papillary carcinoma of the thymus: report of four cases of a new microscopic type of thymic carcinoma. (9669349)	Matsuno Y.... Rosai J.	1998	CALB2, TG
39	The ret/ptc1 oncogene is activated in familial adenomatous polyposis-associated thyroid papillary carcinomas. (9506763)	Cetta F.... Fusco A.	1998	APC
40	Intracystic (encysted) papillary carcinoma of the bre ast: a clinical, pathological, and immunohistochemical study. (9781648)	Leal C.... Lopes C.	1998	MKI67
41	Papillary parathyroid adenoma. A rare occurrence and its importance in differentiation from papillary carcinoma of the thyroid. (9140297)	Ho K.J.	1996	PTHLH
42	Marked increases in cathepsin B and L activities distinguish papillary carcinoma of the thyroid from normal thyroid or thyroid with non-neoplastic disease. (8635854)	Shuja S.... Murnane M.J.	1996	CTSB, CTSL1, TG
43	Tall cell variant of papillary thyroid carcinoma: a reassessment and immunohistochemical study with comparison to the usual type of papillary carcinoma of the thyroid. (8712296)	Ostrowski M.L.... Merino M.J.	1996	MUC1, CEACAM4
44	Preoperative diagnosis of thyroid papillary carcinoma by reverse transcriptase polymerase chain reaction of the MUC1 gene. (8608966)	Weiss M.... Wreschner D.H.	1996	MUC1
45	Simultaneous occurrence of medullary and papillary carcinoma in the same thyroid lobe (7756250)	Meinhard K.... Michailov I.	1995	CALCA
46	Adhesion molecules and lymphocyte recruitment in lymphocytic thyroiditis, thyroid papillary carcinoma and parotid adenolymphoma. (7746747)	Vitolo D.... Baroni C.D.	1994	ICAM1
47	Occult papillary carcinoma of the thyroid presenting as an intratracheal tumour. (7995425)	Paksoy N.... Artvinli M.	1994	TG
48	Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma. (8290261)	Santoro M.... Fusco A.	1994	RET, NRP1, NCOA4
49	Cytology of thyroglossal cyst papillary carcinoma. (8519199)	Chen K.T.	1993	TG
50	Expression of a gene coding for breast tumor-associated antigen in thyroid papillary carcinoma. (2049778)	Weiss M.... Wreschner D.H.	1991	TPO

Genes related to papillary carcinoma according to GeneCards:

(show top 50)    (show all 131)

id	Symbol	Description	Score	GeneCards Section Context
1	CCDC6	coiled-coil domain containing 6	11.1	Summaries, Publications
2	ZNF197	zinc finger protein 197	11.0	Summaries
3	MET	met proto-oncogene (hepatocyte growth factor receptor)	11.0	Publications
4	ERC1	ELKS/RAB6-interacting/CAST family member 1	11.0
5	CCND1	cyclin D1	11.0	Publications
6	NCOA4	nuclear receptor coactivator 4	11.0	Publications
7	PPRC1	peroxisome proliferator-activated receptor gamma, coactivator-related 1	11.0
8	NKX2-1	NK2 homeobox 1	11.0	Publications
9	KRT19	keratin 19	11.0	Publications
10	RET	ret proto-oncogene	11.0	Publications
11	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	11.0	Publications
12	MEN1	multiple endocrine neoplasia I	11.0	Publications
13	S100A4	S100 calcium binding protein A4	11.0	Publications
14	S100A1	S100 calcium binding protein A1	11.0	Publications
15	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
16	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.0	Publications
17	TG	thyroglobulin	11.0	Publications
18	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
19	MUC4	mucin 4, cell surface associated	11.0	Publications
20	TP63	tumor protein p63	11.0	Publications
21	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
22	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
23	AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	11.0	Publications
24	CAV1	caveolin 1, caveolae protein, 22kDa	11.0	Publications
25	RARA	retinoic acid receptor, alpha	11.0	Publications
26	HNF1A	HNF1 homeobox A	11.0	Publications
27	TPO	thyroid peroxidase	11.0	Publications
28	TSHR	thyroid stimulating hormone receptor	11.0	Publications
29	RARB	retinoic acid receptor, beta	11.0	Publications
30	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	11.0	Publications
31	MAPK10	mitogen-activated protein kinase 10	11.0	Publications
32	APC	adenomatous polyposis coli	11.0	Publications
33	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
34	PTEN	phosphatase and tensin homolog	11.0	Publications
35	CXCL12	chemokine (C-X-C motif) ligand 12	11.0	Publications
36	CD44	CD44 molecule (Indian blood group)	11.0	Publications
37	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications
38	MIR221	microRNA 221	10.9	Publications
39	MIR222	microRNA 222	10.9	Publications
40	C8orf4	chromosome 8 open reading frame 4	10.9	Expressions
41	KLK10	kallikrein-related peptidase 10	10.9	Publications
42	CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	10.9	Publications
43	TOB1	transducer of ERBB2, 1	10.9	Publications
44	CCNG2	cyclin G2	10.9	Publications
45	PRSS21	protease, serine, 21 (testisin)	10.9	Publications
46	NPC2	Niemann-Pick disease, type C2	10.9	Publications
47	TACSTD2	tumor-associated calcium signal transducer 2	10.9	Publications
48	MDK	midkine (neurite growth-promoting factor 2)	10.9	Publications
49	CLDN4	claudin 4	10.9	Publications
50	HPN	hepsin	10.9	Publications

Pathways related to papillary carcinoma according to GeneDecks:

(show top 50)    (show all 243)

id	Pathway	Score	Top Affiliating Genes
1	GPCR Pathway36	INF	KIT, BRAF, , , , FOS
2	Endothelin-1 Signaling Pathway36	INF	, CCL20, , ERBB2, , NTRK1
3	Rho Family GTPases36	INF	KIT, VIM, , , , NTRK1
4	Molecular Mechanisms of Cancer36	INF	RARB, CCL20, CCND1, , TP53,
5	Estrogen Pathway36	INF	, TGFA, CXCL12, NTRK1, ,
6	Bladder cancer20	INF	E2F1, RB1, BRAF, VEGFA, ,
7	PTEN Pathway36	INF	FGF2, , , HGF, NRP1, NTRK1
8	Mitochondrial Apoptosis36	INF	KIT, HGF, CXCL12, TGFA, , MET
9	STAT3 Pathway36	INF	BRAF, , BCL2, , CD80, MET
10	Renin-Angiotensin Pathway36	INF	, FGFR2, MET, IL6, MDK, MAPK10
11	Pancreatic Adenocarcinoma36	INF	KIT, , CCND1, ERBB2, TP53,
12	Ras Pathway36	INF	KIT, BRAF, , , , FOS
13	eIF2 Pathway36	INF	FGF2, , BRAF, , MDK,
14	Colorectal Cancer Metastasis36	INF	, CCND1, TP53, PTGS2, CTNNB1,
15	Akt Signaling36	INF	CXCR3, , HGF, KIT, ,
16	MAPK Signaling36	INF	, HGF, FOS, , , FGF2
17	PAK Pathway36	INF	, IL6, MDK, , MAPK10, PTK2B
18	Prostate cancer20	INF	ERBB2, , CCND1, , FGFR2,
19	Antioxidant Action of Vitamin-C36	INF	KIT, , BCL2, , CD80, FOS
20	Melanoma20	INF	RB1, E2F1, HGF, BRAF, , CDKN2A
21	p53 Mediated Apoptosis36	INF	, FGF2, , , BCL2,
22	DHA Signaling36	INF	, , BCL2L1, , KIT, MDK
23	JNK Pathway36	INF	CXCL12, NTRK1, , TP53, , CCL20
24	ILK Signaling36	INF	NTRK1, CTNNB1, PTK2B, PTGS2, , ERBB2
25	14-3-3 Induced Intracellular Signaling36	INF	NTRK1, FGFR2, MDK, MAPK10, ,
26	Non-small cell lung cancer20	INF	RB1, CDKN2A, , , BRAF, E2F1
27	GSK3 Signaling36	INF	, MDK, , IL6, MET, FGFR2
28	ErbB2-ErbB3 Heterodimers36	INF	ERBB2, , E2F1,
29	PPAR Pathway36	INF	NTRK1, , MDK, , NRP1, CXCL12
30	Endometrial cancer20	INF	BRAF, , CDH1, , TP53, CTNNB1
31	Cellular Apoptosis Pathway36	INF	NTRK1, TP53, , BCL2, BCL2L1,
32	Pancreatic cancer20	10.8	BRCA2
33	Colorectal cancer20	10.6	FOS, BRAF
34	p38 Signaling36	INF	CD80, , BCL2, , , KIT
35	TGF-Beta Pathway36	INF	, , FGF2, , MAPK10,
36	Renal cell carcinoma20	INF	, , , MET, , TGFA
37	Development_HGF signaling pathway41	INF	HGF, , PLAU, , , MAPK10
38	Focal adhesion20	INF	HGF, THBS1, CTNNB1, , PTEN, ERBB2
39	Rac1 Pathway36	INF	NTRK1, PTK2B, , NRP1, CXCL12, IL6
40	Pathways in cancer20	INF	FAS, , VEGFA, BRCA2, RB1, RET
41	Glioblastoma Multiforme36	INF	CDKN1B, RB1, BRAF, , E2F1, MGMT
42	Nanog in Mammalian ESC Pluripotency36	INF	TGFA, CXCL12, HGF, NTRK1, CTNNB1, KIT
43	Development HGF signaling pathway10	INF	, FOS, MET, MAPK10, ,
44	Breast Cancer Regulation by Stathmin136	INF	, , FGF2, FGFR2, MAPK10, ERBB2
45	EGF Pathway36	INF	CTNNB1, ERBB2, , , CAV1,
46	Thyroid cancer20	INF	NCOA4, RET, BRAF, , CDH1,
47	NFAT in Immune Response36	INF	, FGF2, KIT, , FOS,
48	Tec Kinases Signaling36	INF	, CXCL12, CXCR3, , HGF,
49	JAK-STAT Pathway36	INF	, FGFR2, MET, IL6, MDK,
50	ERK Signaling36	INF	, , CCL20, , ESR1,

Compounds related to papillary carcinoma according to GeneDecks:

(show top 50)    (show all 423)

id	Compound	Score	Top Affiliating Genes
1	atp32	INF	NCAM1, RET, KIT, RB1, RBL1, BRAF
2	pd 98,05932	INF	RET, KIT, RB1, BRAF, , RARA
3	adriamycin32	INF	RB1, VIM, BRCA1, BRCA2, BIRC5, BCL2
4	hyaluronic acid32 18	INF	VIM, MUC1, MUC16, CEACAM5, CD44, CDH1
5	calcium32 9 18 9	INF	KIT, SFN, RB1, RBL1, BRAF, BRCA1
6	phosphoinositide32	INF	KIT, VIM, BRAF, , RARA,
7	glucose32	INF	KIT, BRAF, , , MUC16, MKI67
8	docetaxel32 34 9 9	INF	KIT, BRCA1, BRCA2, VEGFA, , BIRC5
9	gemcitabine32 34 9 9	INF	PCNA, BRCA1, VEGFA, BIRC5, BCL2, BCL2L1
10	p00332	INF	KIT, RB1, BRCA1, BRCA2, , CHGA
11	suramin32 9 9	INF	NCAM1, PCNA, VEGFA, , FOS, FGF2
12	heparan sulfate32 18	INF	NCAM1, RET, VIM, CD44, , GTDC2
13	calcitriol32 42 9 18 9	INF	RB1, RARA, RARB, CDKN1B, CD83, CD44
14	arsenite32 18	INF	PCNA, VEGFA, RARA, BIRC5, BCL2, BCL2L1
15	fibrinogen32	INF	LGALS3, , , , IL6,
16	sb 20358032 42	INF	RB1, VIM, BRAF, VEGFA, BIRC5, BCL2
17	ribonucleic acid32	INF	RET, KIT, , RARA, RARB,
18	celecoxib32 42 34 9 18 9	INF	PCNA, VEGFA, BIRC5, BCL2, , CDKN1B
19	actinomycin d32	INF	KIT, RB1, VIM, , VEGFA, RARA
20	estradiol32 9 18 9	INF	NCOA4, PCNA, RB1, VIM, BRCA1, BRCA2
21	sp 60012532 42	11.5	TP53
22	formaldehyde32 18	9.8	KIT, PCNA, RB1, VIM, LGALS3, CHGA
23	matrigel32	INF	NCAM1, RB1, , VIM, BRAF, BRCA2
24	tamoxifen32 34 9 9	INF	PCNA, , VIM, BRCA1, BRCA2, VEGFA
25	dihydrotestosterone32 9 18 9	INF	NCOA4, VIM, FGF2, FAS, , ESR1
26	paraffin32	INF	NCAM1, RET, KIT, PCNA, RB1,
27	glycogen32 18	INF	KIT, VIM, , LGALS3, CHGA, S100A1
28	phosphotyrosine32	INF	RET, KIT, BRCA1, , CDH1, FOS
29	geldanamycin32 9 9	INF	BRAF, VEGFA, , BIRC5, BCL2L1, CDH1
30	oxygen32 18	INF	RB1, BRCA1, , , BIRC5, BCL2
31	cytochalasin d32 42	INF	VIM, , CD44, CDH1, FOS,
32	creatinine32	INF	NCAM1, PCNA, VIM, CHGA, MUC1, MUC16
33	nitric oxide32 9 18 9	INF	NCAM1, KIT, RB1, , ,
34	mg 13232 42	INF	PCNA, BRCA1, RARA, BIRC5, BCL2L1,
35	curcumin32	INF	VEGFA, , BIRC5, BCL2, BCL2L1,
36	troglitazone32 42 9 9	INF	RB1, RARA, BIRC5, BCL2, , CDKN1B
37	alanine32	INF	NCAM1, RET, PCNA, RBL1, BRAF, BRCA1
38	roscovitine32	INF	PCNA, VIM, BIRC5, BCL2L1, IFI27, CTNNB1
39	leucine32	INF	RET, KIT, RB1, RBL1, VIM, CDKN1B
40	aspirin32 34 18	INF	PCNA, , , BIRC5, LGALS3, CDH1
41	testosterone32 9 18 9	INF	NCAM1, NCOA4, RET, KIT, PCNA, RB1
42	gnrh32	INF	NCAM1, VIM, , MKI67, , PTK2B
43	biotin32 9 18 9	INF	PCNA, RB1, VIM, MUC1, S100A1, CDKN2A
44	nocodazole32 42 9 9	INF	VIM, BRCA1, , , , BIRC5
45	p00232	INF	KIT, RB1, , BRAF, BRCA1, BRCA2
46	lactate32	INF	NCAM1, KIT, PCNA, VIM, BIRC5, LGALS3
47	cysteine32	INF	PCNA, BRCA1, LMOD1, RARA, RARB,
48	thymidine32 18	INF	KIT, PCNA, RB1, RBL1, BRCA1, BRCA2
49	cholesterol32 9 18 9	INF	RB1, BIRC5, CLDN3, CHGA, MUC1, MUC4
50	agar32	INF	RET, RB1, VIM, BRAF, BRCA1,

Cellular components related to papillary carcinoma according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	INF	CTSB, THBS1, CXCL12, CXCR3, , ICAM1
2	nucleus	GO:005634	INF	, TP53, TP63, PTEN, PTGS2, PTK2B
3	plasma membrane	GO:005886	INF	DIO1, , CTNNB1, NTRK1, NRP1, PTEN
4	caveola	GO:005901	INF	, CAV1, , PTGS2, CTSB, SLC2A1
5	extracellular region	GO:005576	INF	PLAUR, PLAU, NRP1, CTSL1, , PTHLH
6	cytosol	GO:005829	INF	, CTNNB1, , PTK2B, PTEN,
7	extracellular space	GO:005615	INF	CTSB, , PTHLH, CALCA, , PLAU
8	protein complex	GO:043234	INF	HNF1A, TP53, PTGS2, , SYP, CAV1
9	integral to plasma membrane	GO:005887	INF	NTRK1, , TPO, , HPN, PLAUR
10	platelet alpha granule lumen	GO:031093	INF	HGF, THBS1, , , , VEGFA
11	cell surface	GO:009986	INF	, NTRK1, PLAU, PLAUR, HBEGF, THBD
12	intermediate filament	GO:005882	INF	NME1, SLC1A4, KRT19, KRT20, , KRT17
13	nucleoplasm	GO:005654	INF	PCNA, RB1, RBL1, BRCA1, BRCA2,
14	basal plasma membrane	GO:009925	INF	TACSTD2, , CAV1, MET, CLDN4
15	cytoplasm	GO:005737	INF	SMAD4, CXCR3, , NME1, PGR,

Biological processes related to papillary carcinoma according to GeneDecks:

(show top 50)    (show all 70)

id	Name	GO ID	Score	Top Affiliating Genes
1	activation of MAPK activity	GO:000187	INF	HGF, KIT, FGF2, MET, MAPK10,
2	signal transduction	GO:007165	INF	NRP1, , PTK2B, , ERBB2,
3	anti-apoptosis	GO:006916	INF	FAS, , THBS1, TGFA, HGF, MUC1
4	negative regulation of apoptotic process	GO:043066	INF	TP53, , PTEN, PTK2B, , PLAUR
5	MAPK cascade	GO:000165	INF	TGFA, , CAV1, , MEN1,
6	cell cycle arrest	GO:007050	INF	THBS1, TP53, , APC, MEN1, CDKN2A
7	positive regulation of cell proliferation	GO:008284	INF	FGFR2, IL6, , PTEN, PTK2B, PTHLH
8	neuron migration	GO:001764	INF	NKX2-1, , CXCL12, CTNNB1, , MET
9	fibroblast growth factor receptor signaling pathway	GO:008543	INF	PTEN, , , FGFR2, , FGF2
10	negative regulation of cell growth	GO:030308	INF	SMAD4, , TP53, RB1, BCL2, CDKN1B
11	positive regulation of ERK1 and ERK2 cascade	GO:070374	INF	NTRK1, PTK2B, , , FGFR2, FGF2
12	response to estrogen stimulus	GO:043627	INF	KRT19, , , ESR1, CAV1, CCND1
13	negative regulation of transcription, DNA-dependent	GO:045892	INF	, , TP53, TP63, CTNNB1,
14	positive regulation of cell division	GO:051781	INF	TGFA, APC, MDK, MEN1, FGFR2, FGF2
15	positive regulation of peptidyl-serine phosphorylation	GO:033138	INF	, CAV1, IL6, MET, CD44, BCL2
16	vascular endothelial growth factor receptor signaling pathway	GO:048010	INF	PTK2B, , , VEGFA, NRP1
17	virus-host interaction	GO:019048	INF	TP53, KRT8, KRT7, KRT19, ,
18	response to peptide hormone stimulus	GO:043434	INF	CXCL12, , , TFF1, CTSB, FAS
19	Ras protein signal transduction	GO:007265	INF	NTRK1, TP53, , , FGF2, CDKN2A
20	cell migration	GO:016477	INF	, , , APC, , PTEN
21	positive regulation of epithelial cell proliferation	GO:050679	INF	NME1, TGFA, ERBB2, , FGFR2, PAX2
22	regulation of apoptotic process	GO:042981	INF	NME1, , CTSB, TP53, , FAS
23	negative regulation of cell proliferation	GO:008285	INF	NME1, MEN1, FGFR2, FGF2, CDKN2A, CDKN1B
24	negative regulation of cyclin-dependent protein kinase activity	GO:045736	10.3	CDKN1B, CDKN2A, MEN1, APC, PLK1
25	positive regulation of gene expression	GO:010628	10.1	E2F1, KIT, BRAF, VEGFA, CD44, MET
26	cell aging	GO:007569	9.9	TP63, TP53, ICAM1, MET, BCL2, BRCA2
27	G1 phase of mitotic cell cycle	GO:000080	9.8	E2F1, CCND1, CDKN2A, CDKN1B, RBL1, RB1
28	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.0	HGF, NRP1, PTK2B, TP53, IL6, CD44
29	apoptotic process	GO:006915	INF	PTK2B, PTEN, TP63, TP53, , CTNNB1
30	negative regulation of transcription from RNA polymerase II promoter	GO:000122	INF	TP53, , , SMAD4, PLK1, THRB
31	activation of MAPKK activity	GO:000186	INF	, NTRK1
32	response to drug	GO:042493	INF	PTGS2, CTNNB1, , ACTC1, , THBS1
33	neuron apoptotic process	GO:051402	INF	TP63, TP53, FAS, , BCL2, RB1
34	blood coagulation	GO:007596	INF	, PLAU, PLAUR, NOS2, THBD, THBS1
35	response to organic cyclic compound	GO:014070	INF	MET, , CCND1, ICAM1, PTGS2,
36	cell proliferation	GO:008283	INF	PTEN, SMAD4, PLK1, PDPN, TGFA, TACSTD2
37	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO:043154	INF	HGF, THBS1, CD44, PAX2, BIRC5,
38	response to ethanol	GO:045471	INF	NKX2-1, , ACTC1, CTSB, ICAM1, CCND1
39	cellular response to indole-3-methanol	GO:071681	INF	CTNNB1, , CDH1, BRCA1
40	angiogenesis	GO:001525	INF	, PTEN, NRP1, TGFA, CXCR3,
41	response to gamma radiation	GO:010332	INF	TP53, CAV1, MEN1, , BCL2, BRCA2
42	response to hypoxia	GO:001666	INF	CAV1, SMAD4, NOS2, THBS1, CXCL12,
43	organ morphogenesis	GO:009887	INF	THRB, NRP1, , , FGFR2, FGF2
44	branching involved in ureteric bud morphogenesis	GO:001658	INF	SMAD4, FGF2, CD44, BCL2, PAX2,
45	transcription initiation from RNA polymerase II promoter	GO:006367	INF	, SMAD4, THRB, RUNX2, PGR,
46	cellular component movement	GO:006928	INF	CXCR3, , PDPN, PLAUR, PTGS2,
47	positive regulation of transcription, DNA-dependent	GO:045893	INF	E2F1, NKX2-1, RUNX2, , NCOA4, CDKN2A
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	ESR1, TP53, TP63, CTNNB1, , SMAD4
49	ovarian follicle development	GO:001541	INF	, , ICAM1, , BCL2L1, BCL2
50	regulation of angiogenesis	GO:045765	INF	, CTNNB1, ERBB2, IL6, FGF2

Molecular functions related to papillary carcinoma according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:042802	INF	BCL2, BCL2L1, , S100A1, S100A4,
2	growth factor activity	GO:008083	INF	HGF, CXCL12, TFF1, TGFA, HBEGF, MDK
3	steroid hormone receptor activity	GO:003707	INF	PGR, THRB, , , ESR1, RARB
4	protein tyrosine kinase activity	GO:004713	INF	TTK, PTK2B, , ERBB2, MET, FGFR2
5	transmembrane receptor protein tyrosine kinase activity	GO:004714	INF	NTRK1, , , ERBB2, KIT, RET
6	heparin binding	GO:008201	INF	THBS1, HBEGF, NRP1, MDK, FGFR2,
7	sequence-specific DNA binding transcription factor activity	GO:003700	INF	, SMAD4, THRB, , , RUNX2
8	protein homodimerization activity	GO:042803	INF	HNF1A, , PTGS2, NTRK1, SMAD4, NOS2
9	transcription regulatory region DNA binding	GO:044212	INF	CTNNB1, , SMAD4, , NKX2-1, TP63
10	protein heterodimerization activity	GO:046982	INF	MET, HNF1A, ERBB2, TP53, , HGF
11	R-SMAD binding	GO:070412	INF	SMAD4, CTNNB1, , MEN1, FOS
12	protein binding	GO:005515	INF	TP63, KRT8, KRT7, KRT17, , KRT20
13	sequence-specific DNA binding	GO:043565	INF	SMAD4, , THRB, , NKX2-1, PGR
14	enzyme binding	GO:019899	INF	CTNNB1, , PLAUR, , THRB,
15	receptor activity	GO:004872	INF	THBD, , , PLAUR, , ICAM1