MCID: PPL002
MIFTS: 60

Papillary Carcinoma malady

Cancer category

Summaries for Papillary Carcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Papillary thyroid cancer or papillary thyroid carcinoma is the most common type of thyroid cancer,... more...

MalaCards: Papillary Carcinoma, also known as papillary carcinoma nos, is related to breast papillary carcinoma and adenoma. An important gene associated with Papillary Carcinoma is MET (met proto-oncogene), and among its related pathways are GPCR Pathway and Focal Adhesion. The compounds paraffin and vegf have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are mortality/aging and cardiovascular system.

Disease Ontology:8 A carcinoma that is derived from epithelial cells with finger like projections.

Aliases & Classifications for Papillary Carcinoma

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

papillary carcinoma 8
papillary carcinoma nos 8
carcinoma, papillary 61
carcinoma papillary 45


External Ids:

Disease Ontology8 DOID:3113
MeSH35 D002291
SNOMED-CT57 25910003, 189562005
NCIt40 C2927

Related Diseases for Papillary Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Papillary Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1breast papillary carcinoma31.4ERC1
2adenoma31.0CT49, TG, TFF3, MET, NKX2-1, RET
3thyroid adenoma30.9BRAF, RET, LGALS3, TG
4thyroid medullary carcinoma30.8BRAF, CALCA, NKX2-1, RET, LGALS3, TG
5thyroiditis30.8CALCA, TG
6bladder carcinoma30.7SERPINB5, KRT19, CT49, CCND1
7parathyroid carcinoma30.6CCND1, RET
8thyroid cancer30.5CCDC6, BRAF, CALCA, MET, NKX2-1, RET
9graves' disease30.4TG, LGALS3, NKX2-1, CT49, FOXE1
10multinodular goiter30.4TG, KRT19, CALCA
11squamous cell carcinoma30.4CCND1, KRT19, LGALS3
12struma ovarii30.4NKX2-1, TG
13neuroendocrine carcinoma30.3CALCA, NKX2-1, KRT19
14adenocarcinoma30.1HGF, CCND1, BRAF, CT49, TFF3, MET
15congenital hypothyroidism30.1TG, NKX2-1, FOXE1
16thymic carcinoma30.1NKX2-1
17teratoma30.1TG, NKX2-1
18adenoid cystic carcinoma29.9CCND1, S100A1, KRT19, LGALS3, SERPINB5
19thyroid agenesis29.9FOXE1, NKX2-1, LGALS3, TG
20astrocytoma29.9LGALS3, MET, CT49
21mucoepidermoid carcinoma29.9TG, S100A1, CALCA
22renal clear cell carcinoma29.9MET, S100A1
23wilms tumor29.9NKX2-1
24autoimmune thyroiditis29.9CALCA, TG
25thymoma29.9NKX2-1
26hypercalcemia29.9CALCA
27papillary adenoma10.7
28peritoneal carcinoma10.6
29papillary renal carcinoma10.5
30primary peritoneal carcinoma10.5
31tall cell variant papillary carcinoma10.5
32ovary papillary carcinoma10.5
33papillary squamous carcinoma10.4
34gallbladder papillary carcinoma10.3
35thyroid lymphoma10.3
36intraductal papilloma10.3
37bone carcinoma10.2
38papillary renal cell carcinoma10.2
39cribriform carcinoma10.2
40bladder urothelial papillary carcinoma10.2
41bile duct carcinoma10.2
42ductal carcinoma in situ10.2
43columnar cell variant papillary carcinoma10.2
44familial adenomatous polyposis10.2
45choroid plexus carcinoma10.2
46small cell carcinoma10.2
47breast myoepithelial carcinoma10.2
48familial renal papillary carcinoma10.2
49metanephric adenoma10.2
50kidney pelvis papillary carcinoma10.2

Graphical network of the top 20 diseases related to Papillary Carcinoma:



Diseases related to papillary carcinoma

Clinical Features for Papillary Carcinoma

Drugs & Therapeutics for Papillary Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Papillary Carcinoma

Drug clinical trials:

Search ClinicalTrials for Papillary Carcinoma

Search NIH Clinical Center for Papillary Carcinoma

Search CenterWatch for Papillary Carcinoma

Genetic Tests for Papillary Carcinoma

Anatomical Context for Papillary Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Papillary Carcinoma:

33
Bone marrow, Whole blood, Lymph node, Thymus, Brain, Heart, Smooth muscle, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Ovary, Uterus, Prostate, Testis, Cervix, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Parietal lobe, Temporal lobe, Tongue, Fetal liver, Fetal lung, Trachea, Bronchial epithelium, Fetal thyroid, Pituitary, Uterus corpus, Testis germ, Testis leydig

Animal Models for Papillary Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Papillary Carcinoma

Sources:
51PubMed
See all sources

Articles related to Papillary Carcinoma:

(show top 50)    (show all 2241)
idTitleAuthorsYear
1
Diagnostic value of immunohistochemistry for the detection of the BRAFV600E mutation in papillary thyroid carcinoma. Comparative analysis with three DNA-based assays. (24417277)
2014
2
Effects of Silencing the RET/PTC1 Oncogene in Papillary Thyroid Carcinoma by siRNA-Squalene Nanoparticles With and Without Fusogenic Companion GALA-Cholesterol. (23885719)
2014
3
Follicular variant of papillary thyroid carcinoma is a unique clinical entity: a population-based study of 10,740 cases. (23477346)
2013
4
Size discrepancy between sonographic and pathological evaluation of solitary papillary thyroid carcinoma. (23948454)
2013
5
Development of skin hypopigmentation in a patient with metastatic papillary carcinoma thyroid treated with Sorafenib. (23937803)
2013
6
Co-occurrence of papillary thyroid carcinoma and mucosa-associated lymphoid tissue lymphoma in a patient with long-standing hashimoto thyroiditis. (24396701)
2013
7
Predictive value of metastatic cervical lymph node ratio in papillary thyroid carcinoma recurrence. (22730192)
2013
8
Association between Pituitary Langerhans Cell Histiocytosis and Papillary Thyroid Carcinoma. (24367234)
2013
9
Solitary fibrous tumour associated with papillary thyroid carcinoma and pituitary macroadenoma. (23827935)
2013
10
CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma. (23365135)
2013
11
A Case of Multifocal Papillary Thyroid Carcinoma Consisting of One Encapsulated Follicular Variant with BRAF K601E Mutation and Three Conventional Types with BRAF V600E Mutation. (23837025)
2013
12
Basal STAT3 activities are negatively correlated with tumor size in papillary thyroid carcinomas. (21897114)
2012
13
Overexpression of miR-221 is associated with aggressive clinicopathologic characteristics and the BRAF mutation in papillary thyroid carcinomas. (22855362)
2012
14
Warthin-like papillary carcinoma of the thyroid gland: case report and review of the literature. (23243533)
2012
15
BRAFV600E mutation does not mean distant metastasis in thyroid papillary carcinomas. (22740704)
2012
16
Vulvar encapsulated solid papillary carcinoma with neuroendocrine differentiation: a case report. (21427093)
2012
17
Occult infiltrating bi-ventricular papillary renal cell carcinoma metastasis found during coronary artery bypass graft surgery. (22511433)
2012
18
Papillary renal cell carcinoma with extensive paraaortic nodal metastasis mimicking malignant lymphoma. (21960003)
2011
19
Mutational and clinico-pathological analysis of papillary thyroid carcinoma in Serbia. (21498916)
2011
20
TAZ/WWTR1 is overexpressed in papillary thyroid carcinoma. (21131195)
2011
21
Papillary squamous cell carcinoma of the head and neck: a clinicopathologic series. (21035908)
2011
22
Rearrangements of NTRK1 gene in papillary thyroid carcinoma. (19883730)
2010
23
Endobronchial metastasis from primary papillary serous carcinoma of the peritoneum. (19571452)
2009
24
Survivin as a useful adjunct marker for the grading of papillary urothelial carcinoma. (18251581)
2008
25
Metastatic papillary carcinoma of thyroid masquerading as a renal tumour. (18156435)
2008
26
Familial papillary renal carcinoma: cytogenetic characterization in normal and tumor tissues in two brothers. A case report. (18452823)
2008
27
Expression of cytokeratin 19 and protein p63 in fine needle aspiration biopsy of papillary thyroid carcinoma. (18833815)
2008
28
Loss of myoepithelium is variable in solid papillary carcinoma of the breast. (17927587)
2007
29
High prevalence of RET, RAS, and ERK expression in Hashimoto's thyroiditis and in papillary thyroid carcinoma in the Korean population. (17900235)
2007
30
Differential expression of miRNAs in papillary thyroid carcinoma compared to multinodular goiter using formalin fixed paraffin embedded tissues. (18058265)
2007
31
Solid/trabecular variant papillary carcinoma of the thyroid: Report of three cases with fine-needle aspiration. (16955471)
2006
32
Molecular diagnosis of a BRAF papillary thyroid carcinoma with multiple chromosome abnormalities and rare adrenal and hypothalamic metastases. (17199440)
2006
33
Fine-needle aspiration cytology of papillary renal cell carcinoma: the association with concomitant secondary malignancies. (17115441)
2006
34
Papillary carcinoma of the thyroid gland of childhood and adolescence: Morphologic subtypes, biologic behavior and prognosis: a clinicopathologic study of 42 sporadic cases treated at a single institution during a 30-year period. (17063083)
2006
35
Cytokeratins in papillary lesions of the breast: is there a role in distinguishing intraductal papilloma from papillary ductal carcinoma in situ? (15832086)
2005
36
A new BRAF gene mutation detected in a case of a solid variant of papillary thyroid carcinoma. (16021577)
2005
37
Expression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma. (14707866)
2004
38
Papillary and follicular thyroid carcinomas show distinctly different microarray expression profiles and can be distinguished by a minimum of five genes. (15337802)
2004
39
Mutations of the BRAF gene in papillary thyroid carcinoma in a Korean population. (15515191)
2004
40
Decreased expression of p107 is correlated with anaplastic transformation in papillary carcinoma of the thyroid. (14666683)
2003
41
Cytokeratin 19 immunolocalization in cell block preparation of thyroid aspirates. An adjunct to fine-needle aspiration diagnosis of papillary thyroid carcinoma. (12708901)
2003
42
Papillary carcinoma with subacute thyroiditis. (12446927)
2002
43
Solid variant of papillary renal cell carcinoma. (11725629)
2001
44
Concurrent malakoplakia and papillary urothelial carcinoma of the urinary bladder. (11337903)
2001
45
Multiple brown tumors simulating bone metastases: a case of parathyroid adenoma coexisting with papillary carcinoma of the thyroid. (11043714)
2000
46
An overview of the management of papillary and follicular thyroid carcinoma. (10365671)
1999
47
Papillary and follicular thyroid carcinoma metastatic to the skin: a case report and review of the literature. (9848721)
1998
48
Hereditary papillary renal cell carcinoma: clinical studies in 10 families. (7853572)
1995
49
Coexistence of papillary and medullary carcinoma of the thyroid gland-mixed or collision tumour? Clinicopathological analysis of three cases. (8205357)
1994
50
Papillary carcinoma in a huge intrathoracic goiter with tracheal stenosis and invasion. Case report. (8197431)
1993

Genetic Variations for Papillary Carcinoma

Expression for genes affiliated with Papillary Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Papillary Carcinoma

Search GEO for disease gene expression data for Papillary Carcinoma.

Pathways for genes affiliated with Papillary Carcinoma

Sources:
52QIAGEN, 38NCBI BioSystems Database, 30KEGG
See all sources

Compounds for genes affiliated with Papillary Carcinoma

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Papillary Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1paraffin4511.7TG, HGF, CCND1, BRAF, S100A1, CT49
2vegf4511.6CT49, CALCA, BRAF, CCND1, HGF, TFF3
3tyrosine4511.6S100A1, BRAF, CCDC6, CCND1, HGF, TFF3
4retinoic acid45 2412.6CT49, S100A1, BRAF, CCND1, HGF, MET
5progesterone45 60 29 11 2415.5CCND1, BRAF, S100A1, CT49, TFF3, MET
6testosterone45 60 11 2414.4HGF, CCND1, CALCA, CT49, MET, RET
7agar4511.4HGF, CCND1, BRAF, CT49, MET, RET
8cisplatin45 50 60 1114.3HGF, CCND1, BRAF, MET, KRT19, LGALS3
9oligonucleotide4511.3CCND1, BRAF, CT49, MET, NKX2-1, RET
10steroid4511.3CCND1, CT49, TFF3, MET, NKX2-1, MMP11
11alanine4511.3HGF, BRAF, FOXE1, CT49, MET, RET
12matrigel4511.3HGF, CCND1, BRAF, MET, KRT19, LGALS3
13cysteine4511.3S100A1, CT49, TFF3, MET, RET, MMP11
14glycogen45 2412.3HGF, CCND1, S100A1, TFF3, MET, KRT19
15phosphatidylinositol4511.2HGF, CCND1, BRAF, TFF3, MET, RET
16wortmannin4511.2HGF, CCND1, BRAF, MET, RET, LGALS3
17pd 98,0594511.2HGF, CCND1, BRAF, TFF3, MET, RET
18phosphoinositide4511.2HGF, CCND1, BRAF, TFF3, MET, LGALS3
19serine4511.2CCND1, CT49, NKX2-1, RET, KRT19
20thymidine45 2412.2HGF, CCND1, CT49, MET, KRT19, TG
21atp45 2912.2HGF, BRAF, CT49, MET, RET, KRT19
22calcium45 50 11 2414.2HGF, BRAF, CALCA, S100A1, MET, RET
23sodium iodide4511.1BRAF, NKX2-1, RET, TG
24ribonucleic acid4511.1MET, NKX2-1, RET, KRT19, TG
25iodide45 2412.1BRAF, FOXE1, NKX2-1, TG
2612-o-tetradecanoylphorbol 13-acetate4511.1HGF, BRAF, MET, RET, MMP11
27hematoxylin4511.1S100A1, NKX2-1, KRT19, LGALS3
28ly2940024511.1RET, MET, BRAF, CCND1, HGF
29geldanamycin45 50 60 1114.1HGF, CCND1, BRAF, MET
30depsipeptide4511.0CCND1, SERPINB5, TG
31arginine4511.0HGF, BRAF, MET, RET, LGALS3, TG
32p0024511.0SERPINB5, KRT19, MET, BRAF
33genistein45 29 60 2 11 2416.0HGF, CCND1, MET, RET, TG
34iodine45 2412.0TG, MET, BRAF
35formaldehyde45 2412.0LGALS3, KRT19, NKX2-1, CCND1
36estrogen4511.0TG
37imatinib45 50 1113.0HGF, CCND1, BRAF, RET
38b 7234511.0KRT19, NKX2-1, S100A1
39crcs4510.9CCND1, BRAF, MET
40adriamycin4510.9HGF, CCND1
41sorafenib45 50 1112.9CCND1, BRAF, RET
42Cabozantinib1110.8RET, MET
43lactate4510.8HGF, CALCA, KRT19, LGALS3, TG
44nitric oxide45 11 2412.8CALCA, S100A1, TFF3, MET, LGALS3, SERPINB5
45pf 04217903 mesylate6010.8HGF, MET
46su 112746010.7HGF, MET
47threonine4510.7CCND1, BRAF, MET, NKX2-1, RET, LGALS3
48pha 6657526010.7HGF, MET
49crizotinib50 6011.6MET, HGF
50aspirin45 50 29 2413.4SERPINB5, LGALS3, TFF3, HGF

GO Terms for genes affiliated with Papillary Carcinoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Papillary Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:03087810.8TG, NKX2-1, FOXE1
2negative regulation of hydrogen peroxide-mediated programmed cell deathGO:190129910.7MET, HGF
3myoblast proliferationGO:05145010.7MET, HGF
4regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:06066510.6HGF, MET
5thyroid hormone generationGO:00659010.6TG, FOXE1
6liver developmentGO:00188910.5MET, CCND1, HGF
7Leydig cell differentiationGO:03332710.3NKX2-1, CCND1

Molecular functions related to Papillary Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.9SERPINB5, HGF, CCND1, CCDC6, BRAF, CALCA
2protein complex bindingGO:03240310.6KRT19, CALCA, CCND1

Products for genes affiliated with Papillary Carcinoma

  • Antibodies
  • Proteins
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  • Antibodies

Sources for Papillary Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet