MCID: PPL002
MIFTS: 61

Papillary Carcinoma malady

Cancer diseases category

Summaries for Papillary Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Papillary thyroid cancer or papillary thyroid carcinoma is the most common type of thyroid cancer,... more...

MalaCards: Papillary Carcinoma, also known as papillary carcinoma nos, is related to papillary thyroid carcinoma and thyroiditis. An important gene associated with Papillary Carcinoma is MET (met proto-oncogene), and among its related pathways are GPCR Pathway and Focal Adhesion. The compounds paraffin and vegf have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and breast, and related mouse phenotypes are mortality/aging and cardiovascular system.

Disease Ontology:8 A carcinoma that is derived from epithelial cells with finger like projections.

Aliases & Classifications for Papillary Carcinoma

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

papillary carcinoma 8
papillary carcinoma nos 8
carcinoma, papillary 60
carcinoma papillary 44


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Disease Ontology8 DOID:3113
MeSH34 D002291
SNOMED-CT56 25910003, 189562005
NCIt39 C2927

Related Diseases for Papillary Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Papillary Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1papillary thyroid carcinoma31.8ERC1
2thyroiditis31.8CALCA, TG
3breast papillary carcinoma31.3ERC1
4follicular thyroid carcinoma31.0CALCA, TG
5adenoma31.0CT49, TG, TFF3, MET, NKX2-1, RET
6thyroid medullary carcinoma30.8BRAF, CALCA, NKX2-1, RET, LGALS3, TG
7follicular adenoma30.7LGALS3, KRT19
8papilloma30.6CT49
9bladder carcinoma30.6SERPINB5, KRT19, CT49, CCND1
10parathyroid carcinoma30.5CCND1, RET
11thyroid cancer30.5CCDC6, BRAF, CALCA, MET, NKX2-1, RET
12goiter30.5RET, LGALS3, TG, NKX2-1, BRAF, CALCA
13parathyroid adenoma30.5LGALS3, RET, CALCA, CCND1
14endometrial carcinoma30.5CCND1, BRAF, NKX2-1
15graves' disease30.4TG, LGALS3, NKX2-1, CT49, FOXE1
16multinodular goiter30.4TG, KRT19, CALCA
17squamous cell carcinoma30.4CCND1, KRT19, LGALS3
18struma ovarii30.3NKX2-1, TG
19hyperparathyroidism30.3RET, CALCA
20ovarian cancer30.2CCND1, BRAF, MET, NKX2-1, SERPINB5
21neuroendocrine carcinoma30.2CALCA, NKX2-1, KRT19
22hypothyroidism30.2FOXE1, NKX2-1, TG
23adenocarcinoma30.1HGF, CCND1, BRAF, CT49, TFF3, MET
24congenital hypothyroidism30.1TG, NKX2-1, FOXE1
25meningioma30.1CT49, S100A1
26osteosarcoma30.1MET, CT49
27hepatitis30.1HGF
28hemangioma30.1NKX2-1, RET
29melanoma29.9S100A1, BRAF, CCND1, HGF, CT49, MET
30lung adenocarcinoma29.9HGF, CCND1, BRAF, MET, NKX2-1, KRT19
31adenoid cystic carcinoma29.9CCND1, S100A1, KRT19, LGALS3, SERPINB5
32astrocytoma29.9LGALS3, MET, CT49
33breast cancer29.9CCND1, CT49, MMP11, SERPINB5
34mucoepidermoid carcinoma29.9TG, S100A1, CALCA
35laryngeal squamous cell carcinoma29.9CCND1, KRT19
36renal clear cell carcinoma29.9MET, S100A1
37autoimmune thyroiditis29.9CALCA, TG
38leiomyosarcoma29.9S100A1
39hyperthyroidism29.9TG
40neurofibroma29.9S100A1, MET
41thymoma29.9NKX2-1
42hypercalcemia29.8CALCA
43papillary adenoma10.6
44peritonitis10.6
45cervicitis10.5
46tall cell variant papillary carcinoma10.4
47ovary papillary carcinoma10.4
48papillary squamous carcinoma10.4
49in situ carcinoma10.4
50gallbladder papillary carcinoma10.3

Graphical network of the top 20 diseases related to Papillary Carcinoma:



Diseases related to papillary carcinoma

Clinical Features for Papillary Carcinoma

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Drugs & Therapeutics for Papillary Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Papillary Carcinoma

Search NIH Clinical Center for Papillary Carcinoma

Search CenterWatch for Papillary Carcinoma

Genetic Tests for Papillary Carcinoma

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Anatomical Context for Papillary Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Papillary Carcinoma:

32
Thyroid, Lymph node, Breast, Kidney, Pancreas, Endothelial, Lung, Ovary, Bone, Pituitary, Cervix, Brain, Colon, Testes, Thymus, Skin, Liver, B cells, Heart, Salivary gland, Trachea, Bone marrow, Testis, Uterus, Prostate, Monocytes, T cells, Tongue, Small intestine, Smooth muscle, Nk cells

Animal Models for Papillary Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Papillary Carcinoma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.4FOXE1, CALCA, BRAF, CCND1, HGF, PPRC1
2MP:000538511.3LGALS3, HGF, CCND1, BRAF, CALCA, S100A1
3MP:000538111.2CCND1, BRAF, FOXE1, TFF3, MET, NKX2-1
4MP:000200611.1CCND1, BRAF, CALCA, MET, NKX2-1, RET
5MP:000537911.1CCND1, BRAF, FOXE1, MET, NKX2-1, RET
6MP:000538011.0HGF, BRAF, CALCA, PPRC1, MET, RET
7MP:000287311.0CCND1, BRAF, CALCA, S100A1, MET, RET
8MP:000538411.0CCND1, BRAF, MET, NKX2-1, RET, KRT19
9MP:000537610.9CALCA, FOXE1, TFF3, RET, MMP11, TG
10MP:000363110.9CCND1, BRAF, CALCA, MET, NKX2-1, RET
11MP:000538810.6CCND1, MET, LGALS3
12MP:000301210.5HGF, MET, NKX2-1, RET, KRT19, ERC1

Publications for Papillary Carcinoma

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50PubMed
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Articles related to Papillary Carcinoma:

(show top 50)    (show all 2237)
idTitleAuthorsYear
1
Hobnail Variant of Papillary Thyroid Carcinoma: An Institutional Case Series and Molecular Profile. (24417340)
2014
2
Tumor-associated macrophages are involved in tumor progression in papillary renal cell carcinoma. (24327306)
2013
3
Cribriform Morular Variant of Papillary Thyroid Carcinoma in a Patient with an Incidental Neck Lump: a Case Report and Review of the Literature. (24190100)
2013
4
Prognostic value of epidermal growth factor receptor, p53 and galectin-3 expression in papillary thyroid carcinoma. (23569038)
2013
5
Pulmonary metastasis of a papillary thyroid carcinoma and primary lung adenocarcinoma: two coincident carcinomas at the same location. (23414265)
2013
6
Coexistence of malignant struma ovarii and cervical papillary thyroid carcinoma. (24217901)
2013
7
Up-regulation of nuclear receptor coactivator amplified in breast cancer-1 in papillary thyroid carcinoma correlates with lymph node metastasis. (23606350)
2013
8
Preoperative subclinical hypothyroidism in patients with papillary thyroid carcinoma. (23357595)
2013
9
Papillary carcinoma thyroid with uveal metastases. (23334130)
2013
10
Upregulated miR-155 in papillary thyroid carcinoma promotes tumor growth by targeting APC and activating Wnt/I^-catenin signaling. (23796566)
2013
11
Quantitative shear wave elastography as a prognostic implication of papillary thyroid carcinoma (PTC): elasticity index can predict extrathyroidal extension (ETE). (23463092)
2013
12
Prognosis and prognostic factors of patients with papillary thyroid carcinoma requiring resection of recurrent laryngeal nerve due to carcinoma extension. (22200581)
2012
13
Preoperative CA-125 predicts extra-uterine disease and survival in uterine papillary serous carcinoma patients. (22865295)
2012
14
Different clonal origin of bilateral papillary thyroid carcinoma, with a review of the literature. (22434481)
2012
15
Clinicopathologic features of oral squamous papilloma and papillary squamous cell carcinoma: a study of 197 patients from eastern China. (22627075)
2012
16
Clear cell, papillary and chromophobe renal cell carcinoma in patients younger than 20 years old: a clinicopathologic study with follow-up. (22018933)
2012
17
RET protein expression in papillary renal cell carcinoma. (21396847)
2012
18
The preeminence of growth pattern and invasiveness and the limited influence of BRAF and RAS mutations in the occurrence of papillary thyroid carcinoma lymph node metastases. (21796448)
2011
19
Single nucleotide polymorphisms and mRNA expression of VEGF-A in papillary thyroid carcinoma: potential markers for aggressive phenotypes. (21093207)
2011
20
Melanocytic variant of medullary thyroid carcinoma in a previously treated papillary carcinoma patient. (21779621)
2011
21
Paraneoplastic optic neuropathy associated with papillary renal cell carcinoma. (19515641)
2010
22
Increased lipid peroxidation and impaired enzymatic antioxidant defense mechanism in thyroid tissue with multinodular goiter and papillary carcinoma. (20171198)
2010
23
Characterization of CD24 expression in intraductal papillary mucinous neoplasms and ductal carcinoma of the pancreas. (20619441)
2010
24
A unique renal cell carcinoma with features of papillary renal cell carcinoma and thyroid-like carcinoma: a morphological, immunohistochemical and genetic study. (20727022)
2010
25
Papillary renal cell carcinoma with cutaneous metastases. (20234300)
2010
26
Papillary thyroid carcinoma with BRAFV600E mutation: sonographic prediction. (20410389)
2010
27
Is there a role of the histologic subtypes of papillary renal cell carcinoma as a prognostic factor? (19586962)
2009
28
Papillary carcinoma arising from a thyroglossal duct cyst. (19881066)
2009
29
Dual-phase 99mTc-MIBI parathyroid imaging reveals synchronous parathyroid adenoma and papillary thyroid carcinoma: a case report. (19181586)
2008
30
Rare coexistence of invasive papillary carcinoma with infiltrating ductal carcinoma in male breast: report of a case. (18573787)
2008
31
Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. (18474871)
2008
32
Prognosis of patients with benign thyroid diseases accompanied by incidental papillary carcinoma undetectable on preoperative imaging tests. (17571205)
2007
33
Evaluating the degree of conformity of papillary carcinoma and follicular carcinoma to the reported ultrasonographic findings of malignant thyroid tumor. (17554185)
2007
34
Overexpression of claudin-3 and claudin-4 receptors in uterine serous papillary carcinoma: novel targets for a type-specific therapy using Clostridium perfringens enterotoxin (CPE). (17326053)
2007
35
Cystic papillary carcinoma of thyroid gland - A rare case. (23120480)
2007
36
Nitric oxide in papillary thyroid carcinoma: induction of vascular endothelial growth factor D and correlation with lymph node metastasis. (16418215)
2006
37
Selective use of radioactive iodine in the postoperative management of patients with papillary and follicular thyroid carcinoma. (17131429)
2006
38
BRAF mutations in papillary thyroid carcinoma. (17201587)
2006
39
Clinicopathologic analysis of solid papillary carcinoma of the breast and associated invasive carcinomas. (16625097)
2006
40
Common pattern of unusual chromosome abnormalities in hereditary papillary renal carcinoma. (16434318)
2006
41
Papillary carcinoma of thyroid: A 30-yr clinicopathological review of the histological variants. (16627919)
2005
42
Imaging characteristics of papillary renal cell carcinoma by computed tomography scan and magnetic resonance imaging. (16201974)
2005
43
Immunohistochemical detection of p53 homolog p63 in solid cell nests, papillary thyroid carcinoma, and hashimoto's thyroiditis: A stem cell hypothesis of papillary carcinoma oncogenesis. (15116328)
2004
44
Familial papillary thyroid carcinoma. (16209057)
2004
45
High prevalence of RET tyrosine kinase activation in Mexican patients with papillary thyroid carcinomas. (11579677)
2001
46
Papillary and follicular thyroid carcinoma. (11289737)
2000
47
Ret oncogene activation in papillary thyroid carcinoma: prevalence and implication on the histological parameters. (9635675)
1998
48
Papillary renal cell carcinoma. Histology and immunohistochemistry. (7540804)
1995
49
A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases. (3600795)
1987
50
Papillary renal cell carcinoma six years after renal cystectomy. (1274012)
1976

Genetic Variations for Papillary Carcinoma

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Expression for genes affiliated with Papillary Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papillary Carcinoma

Search GEO for disease gene expression data for Papillary Carcinoma.

Pathways for genes affiliated with Papillary Carcinoma

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51QIAGEN, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Papillary Carcinoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Papillary Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1paraffin4411.7SERPINB5, BRAF, S100A1, CT49, TFF3, MET
2vegf4411.6CCND1, BRAF, CALCA, RET, CT49, TFF3
3tyrosine4411.6HGF, CCND1, CCDC6, BRAF, LGALS3, TG
4retinoic acid44 2412.6TG, LGALS3, KRT19, MMP11, S100A1, RET
5progesterone44 59 28 11 2415.5SERPINB5, LGALS3, S100A1, KRT19, MMP11, NKX2-1
6testosterone44 59 11 2414.4KRT19, MET, CT49, RET, TG, SERPINB5
7agar4411.4TG, LGALS3, CCND1, RET, MET, HGF
8cisplatin44 49 59 1114.3BRAF, CCND1, HGF, SERPINB5, MET, TG
9oligonucleotide4411.3LGALS3, MMP11, MET, NKX2-1, CT49, BRAF
10steroid4411.3NKX2-1, TFF3, SERPINB5, KRT19, MMP11, MET
11alanine4411.3HGF, BRAF, CT49, TG, FOXE1, MET
12matrigel4411.3SERPINB5, LGALS3, KRT19, MET, BRAF, CCND1
13cysteine4411.3MET, RET, TG, MMP11, LGALS3, CT49
14glycogen44 2412.3CCND1, S100A1, HGF, TFF3, MET, KRT19
15phosphatidylinositol4411.2RET, HGF, CCND1, LGALS3, MET, BRAF
16wortmannin4411.2LGALS3, RET, MET, BRAF, HGF, CCND1
17pd 98,0594411.2RET, MET, TFF3, BRAF, HGF, CCND1
18phosphoinositide4411.2BRAF, MET, TFF3, LGALS3, CCND1, HGF
19serine4411.2RET, KRT19, CT49, CCND1, NKX2-1
20thymidine44 2412.2HGF, TG, CCND1, CT49, MET, KRT19
21atp44 2812.2HGF, LGALS3, KRT19, BRAF, CT49, RET
22calcium44 49 11 2414.2RET, MMP11, LGALS3, KRT19, BRAF, MET
23sodium iodide4411.1RET, TG, NKX2-1, BRAF
24ribonucleic acid4411.1MET, NKX2-1, RET, KRT19, TG
25iodide44 2412.1BRAF, TG, FOXE1, NKX2-1
2612-o-tetradecanoylphorbol 13-acetate4411.1HGF, BRAF, RET, MMP11, MET
27hematoxylin4411.1S100A1, NKX2-1, KRT19, LGALS3
28ly2940024411.1RET, HGF, CCND1, BRAF, MET
29geldanamycin44 49 59 1114.1MET, CCND1, HGF, BRAF
30depsipeptide4411.0TG, SERPINB5, CCND1
31arginine4411.0MET, LGALS3, HGF, BRAF, TG, RET
32p0024411.0BRAF, MET, KRT19, SERPINB5
33genistein44 28 59 2 11 2416.0MET, CCND1, HGF, RET, TG
34iodine44 2412.0MET, TG, BRAF
35formaldehyde44 2412.0CCND1, LGALS3, KRT19, NKX2-1
36estrogen4411.0TG
37imatinib44 49 1113.0BRAF, RET, HGF, CCND1
38b 7234411.0KRT19, NKX2-1, S100A1
39crcs4410.9BRAF, CCND1, MET
40adriamycin4410.9CCND1, HGF
41sorafenib44 49 1112.9CCND1, RET, BRAF
42Cabozantinib1110.8MET, RET
43lactate4410.8TG, LGALS3, KRT19, CALCA, HGF
44nitric oxide44 11 2412.8S100A1, LGALS3, MET, TFF3, CALCA, SERPINB5
45pf 04217903 mesylate5910.8HGF, MET
46pha 6657525910.7HGF, MET
47threonine4410.7RET, MET, CCND1, BRAF, LGALS3, NKX2-1
48su 112745910.7MET, HGF
49crizotinib49 5911.6HGF, MET
50aspirin44 49 28 2413.4TFF3, SERPINB5, HGF, LGALS3

GO Terms for genes affiliated with Papillary Carcinoma

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16Gene Ontology
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Biological processes related to Papillary Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:03087810.8TG, NKX2-1, FOXE1
2negative regulation of hydrogen peroxide-mediated programmed cell deathGO:190129910.7MET, HGF
3myoblast proliferationGO:05145010.7MET, HGF
4regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:06066510.6HGF, MET
5thyroid hormone generationGO:00659010.6TG, FOXE1
6liver developmentGO:00188910.5MET, CCND1, HGF
7Leydig cell differentiationGO:03332710.3NKX2-1, CCND1

Molecular functions related to Papillary Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.9SERPINB5, HGF, CCND1, CCDC6, BRAF, CALCA
2protein complex bindingGO:03240310.6KRT19, CALCA, CCND1

Products for genes affiliated with Papillary Carcinoma

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  • Antibodies
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Sources for Papillary Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet