MCID: PPL019
MIFTS: 33

Papillary Conjunctivitis malady

Category: Eye diseases

Aliases & Classifications for Papillary Conjunctivitis

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Aliases & Descriptions for Papillary Conjunctivitis:

Name: Papillary Conjunctivitis 11 13 66

Classifications:



External Ids:

Disease Ontology11 DOID:2458
SNOMED-CT60 416878008
NCIt43 C35616

Summaries for Papillary Conjunctivitis

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MalaCards based summary: Papillary Conjunctivitis is related to corneal deposit and giant papillary conjunctivitis. An important gene associated with Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways are IL4-mediated signaling events and Th2 Differentiation Pathway. Affiliated tissues include eye and neutrophil.

Related Diseases for Papillary Conjunctivitis

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Diseases related to Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 167)
idRelated DiseaseScoreTop Affiliating Genes
1corneal deposit30.0CXCL8, IL6
2giant papillary conjunctivitis12.3
3conjunctivitis10.8
4papillary conjunctivitis10.5CCL11, IL4
5dioctophymiasis10.5CCL11, IL4
6epididymis adenocarcinoma10.5CCL11, IL4
7bacterial gastritis10.5CCL11, IL4
8intracranial hypertension10.5CCL11, IL4
9apple allergy10.5CCL11, IL4
10cervix melanoma10.5CCL11, IL4
11central nervous system origin vertigo10.5CCL11, IL4
12pituitary hypoplasia10.5CCL11, IL4
13dacryoadenitis10.5CCL11, IL4
14gait apraxia10.5CCL11, IL4
15juvenile dermatitis herpetiformis10.4CCL11, IL4
16gonadal disease10.4CCL11, CXCL8
17melanoacanthoma10.4CCL11, IL4
18sarcoid meningitis10.4CCL11, IL4
19basidiobolomycosis10.4CXCL8, IL4
20loeffler syndrome10.4CCL11, IL4
21benign fibrous mesothelioma10.4CXCL8, IL4
22benign mammary dysplasia10.3CCL11, IL6
23lymphocytic colitis10.3IL4, IL6
24renal cell carcinoma 410.3IL4, IL6
25scn8a encephalopathy10.3IL4, IL6
26philophthalmiasis10.3IL4, IL6
27anti-basement membrane glomerulonephritis10.3IL4, IL6
28senile cataract10.2IL4, IL6
29tarsal tunnel syndrome10.2CXCL8, IL6
30oesophagostomiasis10.2IL4, IL6
31maligant granulosa cell tumor of ovary10.2CXCL8, IL6
32gonococcal keratitis10.2IL4, IL6
33benign adult familial myoclonic epilepsy10.2CXCL8, IL6
34angioma hereditary neurocutaneous10.2IL6, IL6R
35infancy electroclinical syndrome10.2CXCL8, IL6
36benign lymphoepithelial lesion of salivary gland10.2IL4, IL6
37autosomal dominant cerebellar ataxia10.2CXCL8, IL6
38skin disease10.2CXCL8, IL6
39human herpesvirus 810.2IL6, IL6R
40pasteurellosis10.2CXCL8, IL6
41orbital periostitis10.2IL4, IL6
42subglottis neoplasm10.2CXCL8, IL6
43gasserian ganglion meningioma10.2CXCL8, IL6
44marchiafava bignami disease10.2CXCL8, IL6
45qualitative platelet defect10.2CXCL8, IL6
46inflammatory spondylopathy10.2CXCL8, IL6
47subcorneal pustular dermatosis10.2CXCL8, IL4
48neurofibroma of the esophagus10.2CXCL8, IL6
49ocular cancer10.2CXCL8, IL6
50paraneoplastic polyneuropathy10.2CXCL8, IL6

Graphical network of the top 20 diseases related to Papillary Conjunctivitis:



Diseases related to papillary conjunctivitis

Symptoms for Papillary Conjunctivitis

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Drugs & Therapeutics for Papillary Conjunctivitis

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Drugs for Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LoteprednolPhase 44982034-46-6, 129260-79-3444025, 9865442
Synonyms:
82034-46-6
AC1L9FKJ
AKOS005145741
Alrex
Alrex, Lotemax, Loteprednol etabonate
CDDD-5604
CHEBI:31784
CHEMBL1200865
CID444025
CPD000469178
D01689
DB00873
HGP-1
HMS2051F16
IDR-90102
IDR-90103
Locort
 
Loteflam
Lotemax
Lotemax (TN)
Loteprednol
Loteprednol Etabonate
Loteprednol etabonate
Loteprednol etabonate (JAN/USAN)
Loteprednolum
Loterox
MLS001424221
MolPort-003-848-424
NCGC00164594-01
P-5604
S1669_Selleck
SAM001246630
SMR000469178
ZINC03920673
chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
chloromethyl 17alpha-[(ethoxycarbonyl)oxy]-11beta-hydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylate

Interventional clinical trials:

idNameStatusNCT IDPhase
1Bepreve vs. Alrex in Subjects With Moderate to Severe Allergic ConjunctivitisCompletedNCT01443442Phase 4
2A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5%Active, not recruitingNCT01437982Phase 4
3Clinical Performance of Atypical Contact Lens Powers on Subjects With AstigmatismCompletedNCT00697190
4Assessment of Daily Disposable Silicone Hydrogel Lens WearCompletedNCT01093625
5Clinical Performance of a New Daily Disposable Contact Lens Worn in a Neophyte Population.CompletedNCT00708032
6BIOCLEAN FIRST CARE EX in Combination With Biofinity LensCompletedNCT02196766
7Daily Disposable Silicone Hydrogel Contact Lens, Stenfilcon A, Clinical StudyCompletedNCT02637804
8Perforated Punctal Plugs for Treatment of Papillary Conjunctivitis in Otherwise Healthy PatientsRecruitingNCT02503956

Search NIH Clinical Center for Papillary Conjunctivitis

Genetic Tests for Papillary Conjunctivitis

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Anatomical Context for Papillary Conjunctivitis

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MalaCards organs/tissues related to Papillary Conjunctivitis:

34
Eye, Neutrophil

Animal Models for Papillary Conjunctivitis or affiliated genes

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Publications for Papillary Conjunctivitis

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Articles related to Papillary Conjunctivitis:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Giant papillary conjunctivitis. (18769199)
2008
2
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. (18216583)
2008
3
Papillary conjunctivitis associated with Kikuchi disease. (18724159)
2008
4
Two presentations of contact lens-induced papillary conjunctivitis (CLPC) in hydrogel lens wear: local and general. (16432470)
2006
5
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. (15677951)
2005
6
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. (14566648)
2003
7
Nitric oxide levels in tears of patients with mild forms of papillary conjunctivitis induced by rigid gas-permeable contact lenses. (11838991)
2002
8
Contact lens-induced papillary conjunctivitis is associated with increased albumin deposits on extended wear hydrogel lenses. (12614016)
2002
9
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. (10703125)
1999
10
Sebaceous carcinoma presenting as a unilateral papillary conjunctivitis. (10218701)
1999
11
Giant papillary conjunctivitis--a review. (10337425)
1999
12
Giant papillary conjunctivitis in frequent replacement contact lens wearers: a retrospective study. (10444049)
1999
13
Effect of lodoxamide on tear leukotriene levels in giant papillary conjunctivitis associated with ocular prosthesis. (9785608)
1998
14
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. (9001768)
1997
15
Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. (7586473)
1995
16
A rare case of chronic papillary conjunctivitis diagnosed after several years of evolution. Clinical and pathological findings. (8044334)
1993
17
Unusual causes of giant papillary conjunctivitis. (8458237)
1993
18
Meibomian gland function and giant papillary conjunctivitis. (8420368)
1993
19
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
20
Evaluation of tear protein deposits on contact lenses from patients with and without giant papillary conjunctivitis. (1499118)
1992
21
Immunoglobulin deposition on soft contact lenses: relationship to hydrogel structure and mode of use and giant papillary conjunctivitis. (2407379)
1990
22
Giant papillary conjunctivitis associated with elevated corneal deposits. (1706653)
1990
23
Conjunctival deposition of eosinophil granule major basic protein in vernal keratoconjunctivitis and contact lens-associated giant papillary conjunctivitis. (2750834)
1989
24
Immune responses in monkeys to lenses from patients with contact lens induced giant papillary conjunctivitis. (2917401)
1989
25
Papillary conjunctivitis induced by an epithelialized corneal foreign body. (3362510)
1988
26
A review of contact lens induced giant papillary conjunctivitis. (3336050)
1988
27
Suprofen treatment of contact lens-associated giant papillary conjunctivitis. (3211485)
1988
28
Tear lysozyme and lactoferrin levels in giant papillary conjunctivitis and vernal conjunctivitis. (3147820)
1988
29
Giant papillary conjunctivitis associated with an extruded scleral buckle. Case report. (3619733)
1987
30
Giant papillary conjunctivitis. (3949453)
1986
31
Giant papillary conjunctivitis. (3771999)
1986
32
Suture barb giant papillary conjunctivitis. (6709289)
1984
33
Giant papillary conjunctivitis following cataract extraction. (6367598)
1984
34
Giant papillary conjunctivitis in connection with corneoscleral supramid (nylon) suture knots. (6720279)
1984
35
Treatment of contact lens-induced giant papillary conjunctivitis. (6439429)
1984
36
Transient ptosis secondary to giant papillary conjunctivitis in a hydrogel lens patient. (6643895)
1983
37
Percentage of degranulated mast cells in vernal conjunctivitis and giant papillary conjunctivitis associated with contact-lens wear. (7234932)
1981
38
Giant papillary conjunctivitis after keratoplasty. (7008616)
1981
39
Giant papillary conjunctivitis. (7239822)
1981
40
The clinical management of giant papillary conjunctivitis. (7304717)
1981
41
Mast cell ultrastructure. Comparison in contact lens-associated giant papillary conjunctivitis and vernal conjunctivitis. (7259602)
1981
42
Density of goblet cells in vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis. (7236092)
1981
43
Giant papillary conjunctivitis. (6934657)
1980
44
Giant papillary conjunctivitis: an overview. (448014)
1979
45
Vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis compared and contrasted. (443320)
1979
46
Russell bodies in contact-lens-associated giant papillary conjunctivitis. (217320)
1979
47
Giant papillary conjunctivitis with ocular prostheses. (444123)
1979
48
Giant papillary conjunctivitis induced by hard or soft contact lens wear: quantitative histology. (714378)
1978
49
Giant papillary conjunctivitis (secondary vernal) in association with contact lens wear. (285506)
1978
50
Epidemic keratoconjunctivitis and chronic papillary conjunctivitis in London due to adenovirus type 19. (191054)
1977

Variations for Papillary Conjunctivitis

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Expression for genes affiliated with Papillary Conjunctivitis

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Search GEO for disease gene expression data for Papillary Conjunctivitis.

Pathways for genes affiliated with Papillary Conjunctivitis

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Pathways related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 37)
idSuper pathwaysScoreTop Affiliating Genes
19.6CCL11, IL4
29.6CCL11, IL4
39.4IL4, IL6
49.4IL4, IL6
59.4IL4, IL6
69.3CXCL8, IL6
79.3CXCL8, IL6
89.3CXCL8, IL6
99.3CXCL8, IL6
109.3CXCL8, IL6
119.3CXCL8, IL6
12
Show member pathways
9.3IL6, IL6R
139.3IL6, IL6R
149.3IL6, IL6R
159.3IL6, IL6R
16
Show member pathways
9.3IL6, IL6R
178.9CCL11, CXCL8, IL6
188.9CXCL8, IL4, IL6
198.9CXCL8, IL4, IL6
20
Show member pathways
8.9CXCL8, IL4, IL6
21
Show member pathways
8.9IL4, IL6, IL6R
22
Show member pathways
8.8CXCL8, IL6, IL6R
23
Show member pathways
8.8CXCL8, IL6, IL6R
248.8CXCL8, IL6, IL6R
258.8CXCL8, IL6, IL6R
268.6IL4, IL6, IL7
27
Show member pathways
8.5CCL11, CXCL8, IL4, IL6
288.1IL4, IL6, IL6R, IL7
298.1IL4, IL6, IL6R, IL7
30
Show member pathways
8.1IL4, IL6, IL6R, IL7
317.6CCL11, CXCL8, IL4, IL6, IL7
32
Show member pathways
7.1CCL11, CXCL8, IL4, IL6, IL6R, IL7
33
Show member pathways
7.1CCL11, CXCL8, IL4, IL6, IL6R, IL7
34
Show member pathways
7.1CCL11, CXCL8, IL4, IL6, IL6R, IL7
35
Show member pathways
7.1CCL11, CXCL8, IL4, IL6, IL6R, IL7
36
Show member pathways
7.1CCL11, CXCL8, IL4, IL6, IL6R, IL7
37
Show member pathways
7.1CCL11, CXCL8, IL4, IL6, IL6R, IL7

GO Terms for genes affiliated with Papillary Conjunctivitis

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Cellular components related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor complexGO:000589610.1IL6, IL6R
2extracellular spaceGO:00056157.6CCL11, CXCL8, IL4, IL6, IL7
3extracellular regionGO:00055767.3CCL11, CXCL8, IL6, IL6R, IL7

Biological processes related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell activationGO:005087110.1IL4, IL6
2hepatic immune responseGO:000238410.1IL6, IL6R
3positive regulation of chemokine productionGO:003272210.0IL6, IL6R
4defense response to protozoanGO:004283210.0IL4, IL6
5neutrophil chemotaxisGO:003059310.0CCL11, CXCL8
6endocrine pancreas developmentGO:00310189.9IL6, IL6R
7interleukin-6-mediated signaling pathwayGO:00701029.9IL6, IL6R
8positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.9IL6, IL6R
9acute-phase responseGO:00069539.9IL6, IL6R
10positive regulation of smooth muscle cell proliferationGO:00486619.9IL6, IL6R
11chemokine-mediated signaling pathwayGO:00700989.8CCL11, CXCL8
12positive regulation of T cell differentiationGO:00455829.8IL4, IL7
13positive regulation of leukocyte chemotaxisGO:00026909.8IL6, IL6R
14positive regulation of B cell proliferationGO:00308909.8IL4, IL7
15negative regulation of extrinsic apoptotic signaling pathwayGO:20012379.7IL4, IL7
16humoral immune responseGO:00069599.6IL6, IL7
17positive regulation of interleukin-6 productionGO:00327559.6IL6, IL6R
18positive regulation of T cell proliferationGO:00421029.5IL4, IL6
19monocyte chemotaxisGO:00025489.5CCL11, IL6, IL6R
20positive regulation of osteoblast differentiationGO:00456699.4IL6, IL6R
21cellular response to interleukin-1GO:00713479.4CCL11, CXCL8, IL6
22cellular response to tumor necrosis factorGO:00713569.3CCL11, CXCL8, IL6
23defense response to Gram-negative bacteriumGO:00508299.3IL6, IL6R
24positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.3IL4, IL6, IL6R
25chemotaxisGO:00069359.2CCL11, CXCL8, IL4
26response to cytokineGO:00340979.2IL4, IL6, IL6R
27inflammatory responseGO:00069549.2CCL11, CXCL8, IL6
28positive regulation of cell proliferationGO:00082848.1IL4, IL6, IL6R, IL7

Molecular functions related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor bindingGO:00051389.7IL6, IL6R
2chemokine activityGO:00080099.5CCL11, CXCL8
3growth factor activityGO:00080838.6IL4, IL6, IL7
4cytokine activityGO:00051258.3IL4, IL6, IL7

Sources for Papillary Conjunctivitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet