MCID: PPL019
MIFTS: 35

Papillary Conjunctivitis malady

Summaries for Papillary Conjunctivitis

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32MalaCards
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MalaCards: Papillary Conjunctivitis is related to conjunctivitis and keratoconjunctivitis. An important gene associated with Papillary Conjunctivitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are IL4-mediated signaling events and Immune response CCR3 signaling in eosinophils. The compounds unicap and anti-histamine have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are respiratory system and hematopoietic system.

Aliases & Classifications for Papillary Conjunctivitis

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

papillary conjunctivitis 8 60


External Ids:

Disease Ontology8 DOID:2458
SNOMED-CT56 416878008
NCIt39 C35616

Related Diseases for Papillary Conjunctivitis

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17GeneCards, 18GeneDecks
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Diseases related to Papillary Conjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis31.5IGHE
2keratoconjunctivitis30.4CCL11
3giant papillary conjunctivitis11.0
4vernal conjunctivitis10.5
5chronic conjunctivitis10.2
6papillary carcinoma10.0
7blepharitis10.0
8cataract10.0
9conjunctival deposit10.0
10corneal deposit10.0
11glaucoma10.0
12eosinophilic esophagitis10.0CCL11
13strongyloidiasis10.0IGHE
14pemphigus vulgaris10.0CCL11
15hepatitis10.0CCL11
16pneumonia10.0CCL11
17eosinophilic gastroenteritis10.0CCL11, IGHE
18dermatitis10.0IGHE, CCL11
19allergic conjunctivitis10.0CCL11, IGHE
20eosinophilic pneumonia10.0IGHE, CCL11
21allergic rhinitis10.0IGHE, CCL11
22food allergy10.0CCL11, IGHE
23bronchiolitis10.0CCL11, IGHE
24bronchitis10.0IGHE, CCL11
25uveitis10.0CCL11
26kimura disease10.0IGHE, PRG2
27respiratory failure10.0IGHE, CCL11
28dermatographia10.0PRG2, IGHE
29urticaria10.0IGHE, PRG2
30otitis media10.0IGHE, CCL11
31corneal ulcer10.0PRG2, CCL11
32rheumatoid arthritis10.0CCL11, PRG2
33esophagitis10.0PRG2, CCL11
34skin disease10.0IGHE, CCL11
35vernal keratoconjunctivitis10.0CCL24, CCL11, IGHE
36allergic asthma10.0CCL24, CCL11, IGHE
37cork-handlers' disease10.0PRG2, CCL11
38leukemia10.0PRG2, CCL11
39pulmonary eosinophilia10.0IGHE, PRG2, CCL11
40atopy10.0IGHE, PRG2, CCL11
41hypereosinophilic syndrome10.0CCL11, PRG2, IGHE
42bullous pemphigoid10.0CCL11, PRG2, IGHE
43rhinitis10.0IGHE, PRG2, CCL11
44atopic dermatitis10.0CCL11, PRG2, IGHE
45sinusitis10.0IGHE, PRG2, CCL11
46eosinophilia10.0IGHE, PRG2, CCL11, CCL24
47asthma10.0CCL24, CCL11, PRG2, IGHE

Graphical network of the top 20 diseases related to Papillary Conjunctivitis:



Diseases related to papillary conjunctivitis

Clinical Features for Papillary Conjunctivitis

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Drugs & Therapeutics for Papillary Conjunctivitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Papillary Conjunctivitis

Drug clinical trials:

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Search NIH Clinical Center for Papillary Conjunctivitis

Search CenterWatch for Papillary Conjunctivitis

Genetic Tests for Papillary Conjunctivitis

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Anatomical Context for Papillary Conjunctivitis

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32MalaCards
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MalaCards organs/tissues related to Papillary Conjunctivitis:

32
Eye

Animal Models for Papillary Conjunctivitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Papillary Conjunctivitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5PRG2, CCL11, CCL24
2MP:00053977.9IGHE, PRG2, CCL11, CCL24
3MP:00053877.7CCL24, CCL11, PRG2, IGHE

Publications for Papillary Conjunctivitis

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50PubMed
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Articles related to Papillary Conjunctivitis:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Comparison of olopatadine and fluorometholone in contact lens-induced papillary conjunctivitis. (20531202)
2010
2
Giant papillary conjunctivitis. (18769199)
2008
3
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. (18216583)
2008
4
IgE antibody on worn highly oxygen-permeable silicone hydrogel contact lenses from patients with contact lens-induced papillary conjunctivitis (CLPC). (18327049)
2008
5
Immunohistochemical findings in prosthesis-associated giant papillary conjunctivitis. (17760635)
2007
6
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. (14566648)
2003
7
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. (10703125)
1999
8
Sebaceous carcinoma presenting as a unilateral papillary conjunctivitis. (10218701)
1999
9
Giant papillary conjunctivitis--a review. (10337425)
1999
10
Giant papillary conjunctivitis in frequent replacement contact lens wearers: a retrospective study. (10444049)
1999
11
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. (9124242)
1997
12
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. (8755197)
1996
13
Localised giant papillary conjunctivitis secondary to a dermolipoma. (7556754)
1995
14
Giant papillary conjunctivitis. (7886881)
1994
15
Causative factors in unilateral giant papillary conjunctivitis. (8495560)
1993
16
Meibomian gland function and giant papillary conjunctivitis. (8420368)
1993
17
Meibomian gland function and giant papillary conjunctivitis. (8420369)
1993
18
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
19
Surgical treatment and desensitization therapy of giant papillary allergic conjunctivitis. (1484672)
1992
20
Treatment of giant papillary conjunctivitis with cromolyn sodium. (1559288)
1992
21
Neutrophil chemotactic factors in the tears of giant papillary conjunctivitis patients. (1846131)
1991
22
Immunoglobulin deposition on soft contact lenses: relationship to hydrogel structure and mode of use and giant papillary conjunctivitis. (2407379)
1990
23
Eosinophil granule major basic protein in contact lenses of patients with giant papillary conjunctivitis. (2199092)
1990
24
Association of giant papillary conjunctivitis with seasonal allergies. (2320363)
1990
25
Giant papillary conjunctivitis associated with elevated corneal deposits. (1706653)
1990
26
Protein and elemental analysis of contact lenses of patients with superior limbic keratoconjunctivitis or giant papillary conjunctivitis. (2717140)
1989
27
Immune responses in monkeys to lenses from patients with contact lens induced giant papillary conjunctivitis. (2917401)
1989
28
Contact lens induced giant papillary conjunctivitis: a retrospective study. (2708768)
1989
29
HPLC analysis of tear proteins in giant papillary conjunctivitis. (2625085)
1989
30
Papillary conjunctivitis induced by an epithelialized corneal foreign body. (3362510)
1988
31
Tear lysozyme and lactoferrin levels in giant papillary conjunctivitis and vernal conjunctivitis. (3147820)
1988
32
Giant papillary conjunctivitis associated with an extruded scleral buckle. Case report. (3619733)
1987
33
Giant papillary conjunctivitis from an exposed prolene suture. (3756614)
1986
34
Blepharoptosis associated with giant papillary conjunctivitis. (3778291)
1986
35
Suture barb giant papillary conjunctivitis. (6709289)
1984
36
Tear immunoglobulins in giant papillary conjunctivitis induced by contact lenses. (6702985)
1984
37
Giant papillary conjunctivitis in connection with corneoscleral supramid (nylon) suture knots. (6720279)
1984
38
Treatment of contact lens-induced giant papillary conjunctivitis. (6439429)
1984
39
Tear immunoglobulins in giant papillary conjunctivitis induced by contact lenses. (6624827)
1983
40
Cromolyn treatment of giant papillary conjunctivitis. (6814405)
1982
41
Clinical aspects of giant papillary conjunctivitis. (7339618)
1981
42
Giant papillary conjunctivitis after keratoplasty. (7008616)
1981
43
Giant papillary conjunctivitis. (7239822)
1981
44
Density of goblet cells in vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis. (7236092)
1981
45
Giant papillary conjunctivitis with ocular prostheses. (7362515)
1980
46
Giant papillary conjunctivitis and ptosis in a contact lens wearer. (458521)
1979
47
Vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis compared and contrasted. (443320)
1979
48
Russell bodies in contact-lens-associated giant papillary conjunctivitis. (217320)
1979
49
Giant papillary conjunctivitis induced by hard or soft contact lens wear: quantitative histology. (714378)
1978
50
Giant papillary conjunctivitis (secondary vernal) in association with contact lens wear. (285506)
1978

Genetic Variations for Papillary Conjunctivitis

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Expression for genes affiliated with Papillary Conjunctivitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papillary Conjunctivitis

Search GEO for disease gene expression data for Papillary Conjunctivitis.

Pathways for genes affiliated with Papillary Conjunctivitis

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37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN
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Pathways related to Papillary Conjunctivitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4IGHE, CCL11
2
Immune response CCR3 signaling in eosinophils
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9.3CCL24, CCL11
3
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9.1PRG2, CCL11
4
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8.5PRG2, CCL11, CCL24
5
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8.5PRG2, CCL11, CCL24

Compounds for genes affiliated with Papillary Conjunctivitis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Papillary Conjunctivitis according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1unicap449.8IGHE, CCL11
2anti-histamine449.8CCL11, IGHE
3sodium cromoglycate449.7IGHE, CCL11
4cetirizine44 28 11 2412.7IGHE, CCL11
5ketotifen44 1110.7IGHE, CCL11
6montelukast44 49 28 1112.7IGHE, CCL11
7budesonide44 49 1111.7IGHE, CCL11
8salbutamol44 49 28 11 2413.7CCL11, IGHE
9fluticasone propionate44 49 59 1112.6IGHE, CCL11
10pertussis449.6CCL11, IGHE
11prednisolone44 28 1111.4IGHE, CCL11
12ccl344 2810.4CCL11, CCL24
13ltc4449.4PRG2, CCL11
14heparin44 28 11 2412.2PRG2, CCL11
15tarc449.2CCL24, CCL11, IGHE
16fmlp449.1PRG2, CCL11
17oxygen44 2410.0CCL11, PRG2
18pgd2449.0IGHE, PRG2, CCL11
19methacholine44 1110.0IGHE, PRG2, CCL11
20allergens448.9IGHE, PRG2, CCL11
21indomethacin44 59 28 1111.9CCL11, PRG2, IGHE
22superoxide44 249.7PRG2, CCL11, CCL24
23histamine44 28 2410.4IGHE, PRG2, CCL11, CCL24
24actinomycin d448.3CCL24, CCL11, PRG2, IGHE
25retinoic acid44 249.3IGHE, PRG2, CCL11

GO Terms for genes affiliated with Papillary Conjunctivitis

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16Gene Ontology
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Biological processes related to Papillary Conjunctivitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:0482459.5CCL24, CCL11
2positive regulation of Rac GTPase activityGO:0328559.5CCL11, CCL24
3positive regulation of actin filament polymerizationGO:0308389.5CCL11, CCL24
4positive regulation of endothelial cell proliferationGO:0019389.4CCL24, CCL11
5positive regulation of angiogenesisGO:0457669.4CCL11, CCL24
6cytoskeleton organizationGO:0070109.3CCL11, CCL24
7positive regulation of cell migrationGO:0303359.3CCL11, CCL24
8regulation of cell shapeGO:0083609.2CCL24, CCL11
9chemotaxisGO:0069359.0CCL11, CCL24
10immune responseGO:0069558.2IGHE, PRG2, CCL11, CCL24

Molecular functions related to Papillary Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.3CCL11, CCL24

Products for genes affiliated with Papillary Conjunctivitis

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Sources for Papillary Conjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet