MCID: PPL019
MIFTS: 34

Papillary Conjunctivitis malady

Category: Eye diseases

Aliases & Classifications for Papillary Conjunctivitis

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Aliases & Descriptions for Papillary Conjunctivitis:

Name: Papillary Conjunctivitis 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:2458
SNOMED-CT62 416878008
NCIt45 C35616

Summaries for Papillary Conjunctivitis

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MalaCards based summary: Papillary Conjunctivitis is related to corneal deposit and giant papillary conjunctivitis. An important gene associated with Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways are Th2 Differentiation Pathway and IL4-mediated signaling events. Affiliated tissues include eye and neutrophil.

Related Diseases for Papillary Conjunctivitis

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Diseases related to Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1corneal deposit29.7CXCL8, IL6
2giant papillary conjunctivitis12.2
3conjunctivitis10.6
4dioctophymiasis10.4CCL11, IL4
5epididymis adenocarcinoma10.4CCL11, IL4
6bacterial gastritis10.4CCL11, IL4
7intracranial hypertension10.4CCL11, IL4
8apple allergy10.4CCL11, IL4
9cervix melanoma10.4CCL11, IL4
10central nervous system origin vertigo10.4CCL11, IL4
11pituitary hypoplasia10.4CCL11, IL4
12dacryoadenitis10.4CCL11, IL4
13gait apraxia10.4CCL11, IL4
14juvenile dermatitis herpetiformis10.4CCL11, IL4
15gonadal disease10.4CCL11, CXCL8
16melanoacanthoma10.4CCL11, IL4
17non-gestational choriocarcinoma10.4CCL11, CCL2
18sarcoid meningitis10.3CCL11, IL4
19basidiobolomycosis10.3CXCL8, IL4
20gonococcal synovitis10.3CCL2, IL4
21plantar wart10.3CXCL8, IL4
22loeffler syndrome10.3CCL11, IL4
23benign fibrous mesothelioma10.3CXCL8, IL4
24cytomegalovirus retinitis10.3CCL2, CXCL8
25flinders island spotted fever10.3CCL2, CXCL8
26t-cell lymphoma 1a10.3CCL2, CXCL8
27progressive relapsing multiple sclerosis10.2CCL2, IL4
28secondary lacrimal atrophy10.2CCL2, IL4
29dengue disease10.2CCL2, IL4
30lymphocytic colitis10.2IL4, IL6
31renal cell carcinoma 410.2IL4, IL6
32louping ill10.2CCL2, CXCL8
33scn8a encephalopathy10.2IL4, IL6
34philophthalmiasis10.2IL4, IL6
35sinusitis10.2CCL2, CXCL8
36tarsal tunnel syndrome10.2CXCL8, IL6
37maligant granulosa cell tumor of ovary10.2CXCL8, IL6
38senile cataract10.2IL4, IL6
39benign adult familial myoclonic epilepsy10.2CXCL8, IL6
40antigen-peptide-transporter 2 deficiency10.2CCL2, IL6
41infancy electroclinical syndrome10.2CXCL8, IL6
42gonococcal keratitis10.2IL4, IL6
43autosomal dominant cerebellar ataxia10.2CXCL8, IL6
44skin disease10.2CXCL8, IL6
45pasteurellosis10.2CXCL8, IL6
46benign lymphoepithelial lesion of salivary gland10.2IL4, IL6
47subglottis neoplasm10.2CXCL8, IL6
48orbital periostitis10.2IL4, IL6
49opiate dependence10.2CCL2, IL6
50osteogenesis imperfecta, type x10.2CXCL8, IL6

Graphical network of the top 20 diseases related to Papillary Conjunctivitis:



Diseases related to papillary conjunctivitis

Symptoms & Phenotypes for Papillary Conjunctivitis

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Drugs & Therapeutics for Papillary Conjunctivitis

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Drugs for Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LoteprednolapprovedPhase 45082034-46-6, 129260-79-3444025, 9865442
Synonyms:
82034-46-6
AC1L9FKJ
AKOS005145741
Alrex
Alrex, Lotemax, Loteprednol etabonate
CDDD-5604
CHEBI:31784
CHEMBL1200865
CID444025
CPD000469178
D01689
DB00873
HGP-1
HMS2051F16
IDR-90102
IDR-90103
Locort
 
Loteflam
Lotemax
Lotemax (TN)
Loteprednol
Loteprednol Etabonate
Loteprednol etabonate
Loteprednol etabonate (JAN/USAN)
Loteprednolum
Loterox
MLS001424221
MolPort-003-848-424
NCGC00164594-01
P-5604
S1669_Selleck
SAM001246630
SMR000469178
ZINC03920673
chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
chloromethyl 17alpha-[(ethoxycarbonyl)oxy]-11beta-hydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylate
2Anti-Allergic AgentsPhase 41490
3Histamine H1 AntagonistsPhase 4782
4Histamine AntagonistsPhase 4946

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5%Unknown statusNCT01437982Phase 4
2Bepreve vs. Alrex in Subjects With Moderate to Severe Allergic ConjunctivitisCompletedNCT01443442Phase 4
3Clinical Performance of a New Daily Disposable Contact Lens Worn in a Neophyte Population.CompletedNCT00708032
4BIOCLEAN FIRST CARE EX in Combination With Biofinity LensCompletedNCT02196766
5Clinical Performance of Atypical Contact Lens Powers on Subjects With AstigmatismCompletedNCT00697190
6Assessment of Daily Disposable Silicone Hydrogel Lens WearCompletedNCT01093625
7Daily Disposable Silicone Hydrogel Contact Lens, Stenfilcon A, Clinical StudyCompletedNCT02637804
8Perforated Punctal Plugs for Treatment of Papillary Conjunctivitis in Otherwise Healthy PatientsRecruitingNCT02503956

Search NIH Clinical Center for Papillary Conjunctivitis

Genetic Tests for Papillary Conjunctivitis

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Anatomical Context for Papillary Conjunctivitis

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MalaCards organs/tissues related to Papillary Conjunctivitis:

36
Eye, Neutrophil

Publications for Papillary Conjunctivitis

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Articles related to Papillary Conjunctivitis:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Risk factors for contact lens-induced papillary conjunctivitis associated with silicone hydrogel contact lens wear. (24681609)
2014
2
Comparison of tacrolimus, fluorometholone, and saline in mild-to-moderate contact lens-induced papillary conjunctivitis. (22821643)
2012
3
Comparison of olopatadine and fluorometholone in contact lens-induced papillary conjunctivitis. (20531202)
2010
4
Contact lens induced papillary conjunctivitis with silicone hydrogel lenses. (19181562)
2009
5
Giant papillary conjunctivitis. (18769199)
2008
6
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. (18216583)
2008
7
Papillary conjunctivitis associated with Kikuchi disease. (18724159)
2008
8
Filtering bleb-induced giant papillary conjunctivitis. (17826299)
2008
9
Giant papillary conjunctivitis. (18282547)
2008
10
IgE antibody on worn highly oxygen-permeable silicone hydrogel contact lenses from patients with contact lens-induced papillary conjunctivitis (CLPC). (18327049)
2008
11
M cells are involved in pathogenesis of human contact lens-associated giant papillary conjunctivitis. (17557145)
2007
12
Immunohistochemical findings in prosthesis-associated giant papillary conjunctivitis. (17760635)
2007
13
Two presentations of contact lens-induced papillary conjunctivitis (CLPC) in hydrogel lens wear: local and general. (16432470)
2006
14
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
15
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. (15677951)
2005
16
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. (14566648)
2003
17
Contact lens chemistry and giant papillary conjunctivitis. (12772728)
2003
18
Nitric oxide levels in tears of patients with mild forms of papillary conjunctivitis induced by rigid gas-permeable contact lenses. (11838991)
2002
19
Contact lens-induced papillary conjunctivitis is associated with increased albumin deposits on extended wear hydrogel lenses. (12614016)
2002
20
General and local contact lens induced papillary conjunctivitis (CLPC). (12033982)
2002
21
Giant papillary conjunctivitis associated with an ocular prosthesis. (12366372)
2001
22
Delayed tear clearance in contact lens associated papillary conjunctivitis. (11462163)
2001
23
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study (10844086)
2000
24
Meibomian gland status and prevalence of giant papillary conjunctivitis in contact lens wearers. (15326900)
2000
25
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. (10703125)
1999
26
Sebaceous carcinoma presenting as a unilateral papillary conjunctivitis. (10218701)
1999
27
Giant papillary conjunctivitis--a review. (10337425)
1999
28
Giant papillary conjunctivitis in frequent replacement contact lens wearers: a retrospective study. (10444049)
1999
29
Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. (10410873)
1999
30
Effect of lodoxamide on tear leukotriene levels in giant papillary conjunctivitis associated with ocular prosthesis. (9785608)
1998
31
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. (9001768)
1997
32
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. (9124242)
1997
33
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. (8755197)
1996
34
Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. (7586473)
1995
35
Localised giant papillary conjunctivitis secondary to a dermolipoma. (7556754)
1995
36
Contact lens type, material, and deposits and giant papillary conjunctivitis. (7712614)
1995
37
Effect of extended wear disposable contact lenses on tear LTC4 in giant papillary conjunctivitis. (22827277)
1995
38
Bilateral giant papillary conjunctivitis related to glaucoma drainage surgery blebs. (7995075)
1994
39
Giant papillary conjunctivitis. (7886881)
1994
40
A rare case of chronic papillary conjunctivitis diagnosed after several years of evolution. Clinical and pathological findings. (8044334)
1993
41
Unusual causes of giant papillary conjunctivitis. (8458237)
1993
42
Meibomian gland function and giant papillary conjunctivitis. (8420368)
1993
43
Causative factors in unilateral giant papillary conjunctivitis. (8495560)
1993
44
Comparison of the clinical performance of the Acuvue disposable contact lens and CSI lens in patients with giant papillary conjunctivitis. (8470716)
1993
45
N-acetyl-aspartyl glutamic acid (NAAGA) topical eyedrops in the treatment of giant papillary conjunctivitis (GPC). (7910133)
1993
46
Nedocromil sodium in contact-lens-associated papillary conjunctivitis. (8253222)
1993
47
Meibomian gland function and giant papillary conjunctivitis. (8420369)
1993
48
Safety and efficacy of loteprednol etabonate for treatment of papillae in contact lens-associated giant papillary conjunctivitis. (8319490)
1993
49
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
50
Evaluation of tear protein deposits on contact lenses from patients with and without giant papillary conjunctivitis. (1499118)
1992

Variations for Papillary Conjunctivitis

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Expression for genes affiliated with Papillary Conjunctivitis

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Search GEO for disease gene expression data for Papillary Conjunctivitis.

Pathways for genes affiliated with Papillary Conjunctivitis

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Pathways related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 32)
idSuper pathwaysScoreTop Affiliating Genes
19.6CCL11, IL4
29.6CCL11, IL4
39.5CCL11, CCL2
4
Show member pathways
9.4CCL2, CXCL8
59.4IL4, IL6
69.4IL4, IL6
79.3CXCL8, IL6
89.3CXCL8, IL6
99.3CXCL8, IL6
109.3CXCL8, IL6
11
Show member pathways
9.0CCL11, CCL2, CXCL8
128.9CCL11, CXCL8, IL6
138.9CXCL8, IL4, IL6
14
Show member pathways
8.9CXCL8, IL4, IL6
15
Show member pathways
8.8CCL2, CXCL8, IL6
168.8CCL2, CXCL8, IL6
178.8CCL2, CXCL8, IL6
188.8CCL2, CXCL8, IL6
198.8CCL2, CXCL8, IL6
208.6IL4, IL6, IL7
218.6IL4, IL6, IL7
228.6IL4, IL6, IL7
23
Show member pathways
8.5CCL11, CXCL8, IL4, IL6
248.4CCL2, CXCL8, IL4, IL6
25
Show member pathways
8.4CCL2, CXCL8, IL4, IL6
26
Show member pathways
7.1CCL11, CCL2, CXCL8, IL4, IL6, IL7
27
Show member pathways
7.1CCL11, CCL2, CXCL8, IL4, IL6, IL7
28
Show member pathways
7.1CCL11, CCL2, CXCL8, IL4, IL6, IL7
297.1CCL11, CCL2, CXCL8, IL4, IL6, IL7
30
Show member pathways
7.1CCL11, CCL2, CXCL8, IL4, IL6, IL7
31
Show member pathways
7.1CCL11, CCL2, CXCL8, IL4, IL6, IL7
32
Show member pathways
7.1CCL11, CCL2, CXCL8, IL4, IL6, IL7

GO Terms for genes affiliated with Papillary Conjunctivitis

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Cellular components related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.3CCL11, CCL2, CXCL8, IL6, IL7
2extracellular spaceGO:00056157.1CCL11, CCL2, CXCL8, IL4, IL6, IL7

Biological processes related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interferon-gammaGO:007134610.3CCL11, CCL2
2lymphocyte chemotaxisGO:004824710.3CCL11, CCL2
3positive regulation of endothelial cell proliferationGO:000193810.2CCL11, CCL2
4cellular response to fibroblast growth factor stimulusGO:004434410.2CCL2, CXCL8
5PERK-mediated unfolded protein responseGO:003649910.1CCL2, CXCL8
6defense response to protozoanGO:004283210.1IL4, IL6
7positive regulation of B cell activationGO:005087110.1IL4, IL6
8cellular response to dexamethasone stimulusGO:007154910.1CCL2, IL6
9positive regulation of T cell proliferationGO:004210210.1IL4, IL6
10response to cytokineGO:003409710.0IL4, IL6
11regulation of vascular endothelial growth factor productionGO:001057410.0CCL2, IL6
12response to amino acidGO:004320010.0CCL2, IL6
13response to antibioticGO:004667710.0CCL2, IL6
14response to bacteriumGO:000961710.0CCL2, IL6
15negative regulation of extrinsic apoptotic signaling pathwayGO:20012379.9IL4, IL7
16positive regulation of B cell proliferationGO:00308909.9IL4, IL7
17positive regulation of T cell differentiationGO:00455829.9IL4, IL7
18chemokine-mediated signaling pathwayGO:00700989.8CCL11, CCL2, CXCL8
19neutrophil chemotaxisGO:00305939.7CCL11, CCL2, CXCL8
20monocyte chemotaxisGO:00025489.6CCL11, CCL2, IL6
21positive regulation of ERK1 and ERK2 cascadeGO:00703749.6CCL11, CCL2, IL6
22regulation of cell shapeGO:00083609.6CCL11, CCL2, IL6
23cellular response to lipopolysaccharideGO:00712229.6CCL2, CXCL8, IL6
24response to heatGO:00094089.3CCL2, IL6
25response to drugGO:00424939.3CCL2, IL4, IL6
26chemotaxisGO:00069359.3CCL11, CCL2, CXCL8, IL4
27humoral immune responseGO:00069599.2CCL2, IL6, IL7
28cellular response to interleukin-1GO:00713479.1CCL11, CCL2, CXCL8, IL6
29cellular response to tumor necrosis factorGO:00713569.1CCL11, CCL2, CXCL8, IL6
30inflammatory responseGO:00069549.1CCL11, CCL2, CXCL8, IL6

Molecular functions related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.7CCL11, CCL2, CXCL8
2cytokine activityGO:00051258.6CCL2, IL4, IL6, IL7
3growth factor activityGO:00080838.6IL4, IL6, IL7

Sources for Papillary Conjunctivitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet