MCID: PPL019
MIFTS: 30

Papillary Conjunctivitis malady

Eye diseases category

Aliases & Classifications for Papillary Conjunctivitis

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Aliases & Descriptions for Papillary Conjunctivitis:

Name: Papillary Conjunctivitis 10 65


Classifications:



External Ids:

Disease Ontology10 DOID:2458
SNOMED-CT59 416878008
NCIt42 C35616

Summaries for Papillary Conjunctivitis

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MalaCards based summary: Papillary Conjunctivitis is related to conjunctivitis and giant papillary conjunctivitis. An important gene associated with Papillary Conjunctivitis is CCL11 (Chemokine (C-C Motif) Ligand 11), and among its related pathways are IL4-mediated signaling events and Cytokines and Inflammatory Response. Affiliated tissues include eye and neutrophil, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Papillary Conjunctivitis

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Diseases related to Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis31.9CCL11, IL4
2giant papillary conjunctivitis11.1
3vernal conjunctivitis10.4
4keratoconjunctivitis10.4
5ptosis10.2
6vernal keratoconjunctivitis10.2
7coenurosis10.2CCL11, IL4
8acute apical periodontitis10.2CCL11, IL4
9thalamic neoplasm10.2CCL11, IL4
10benign deep fibrous histiocytoma10.2CCL11, IL4
11eosinophilic gastroenteritis10.2CCL11, IL4
12chronic cystitis10.2CCL11, IL4
13verrucous nevus acanthokeratolytic10.2CCL11, IL4
14nasopharyngeal disease10.2CCL11, IL4
15pulmonary large cell neuroendocrine carcinoma10.2CCL11, IL4
16hypotrichosis of eyelid10.2CCL11, IL4
17west nile fever10.2IL4, IL7
18blepharoconjunctivitis10.2IL4, LTF
19cd45 deficiency10.2IL4, IL7
20leukodystrophy10.1CCL11, IL4
21pharyngitis10.1CCL11, CXCL8
22acute allergic serous otitis media10.1IL4, LTF
23schistosomiasis10.1CCL11, CXCL8
24alternating esotropia10.1IL4, IL7
25basidiobolomycosis10.1CXCL8, IL4
26pes anserinus tendinitis or bursitis10.1CXCL8, IL4
27sebaceous adenoma10.1CXCL8, IL4
28clear cell renal cell carcinoma10.1CXCL8, IL4
29acute diarrhea10.1CXCL8, LTF
30gastroschisis10.1CXCL8, LTF
31hair defect with photosensitivity and mental retardation10.1CXCL8, LTF
32pancreatic vasoactive intestinal peptide producing tumor10.1CXCL8, LTF
33single ventricular heart10.1CXCL8, IL4
34splenic sequestration10.1CXCL8, IL4
35gastroesophageal reflux10.1CCL11, CXCL8
36hyperinsulinemic hypoglycemia10.1CXCL8, LTF
37cataract10.1
38stenosis of lacrimal punctum10.1
39allergic conjunctivitis10.1
40blepharitis10.1
41conjunctival deposit10.1
42conjunctival disease10.1
43corneal deposit10.1
44excessive tearing10.1
45kikuchi disease10.1
46superior limbic keratoconjunctivitis10.1
47loeffler syndrome10.1CCL11, IL6
48esophagus adenocarcinoma10.1CCL11, CXCL8
49tropical spastic paraparesis10.1CCL11, IL6
50pasteurellosis10.0CXCL8, LTF

Graphical network of the top 20 diseases related to Papillary Conjunctivitis:



Diseases related to papillary conjunctivitis

Symptoms for Papillary Conjunctivitis

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Drugs & Therapeutics for Papillary Conjunctivitis

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Drugs for Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Loteprednol etabonatePhase 44482034-46-6444025
Synonyms:
82034-46-6
AC1L9FKJ
AKOS005145741
Alrex
Alrex, Lotemax, Loteprednol etabonate
CDDD-5604
CHEBI:31784
CHEMBL1200865
CID444025
CPD000469178
D01689
DB00873
HGP-1
HMS2051F16
IDR-90102
IDR-90103
 
Locort
Loteflam
Lotemax
Lotemax (TN)
Loteprednol etabonate
Loteprednol etabonate (JAN/USAN)
Loterox
MLS001424221
MolPort-003-848-424
NCGC00164594-01
P-5604
S1669_Selleck
SAM001246630
SMR000469178
ZINC03920673
chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
chloromethyl 17alpha-[(ethoxycarbonyl)oxy]-11beta-hydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylate

Interventional clinical trials:

idNameStatusNCT IDPhase
1Bepreve vs. Alrex in Subjects With Moderate to Severe Allergic ConjunctivitisCompletedNCT01443442Phase 4
2A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5%Active, not recruitingNCT01437982Phase 4
3Clinical Performance of Atypical Contact Lens Powers on Subjects With AstigmatismCompletedNCT00697190
4Assessment of Daily Disposable Silicone Hydrogel Lens WearCompletedNCT01093625
5Clinical Performance of a New Daily Disposable Contact Lens Worn in a Neophyte Population.CompletedNCT00708032
6Perforated Punctal Plugs for Treatment of Papillary Conjunctivitis in Otherwise Healthy PatientsRecruitingNCT02503956
7Daily Disposable Silicone Hydrogel Contact Lens, Stenfilcon A, Clinical StudyNot yet recruitingNCT02637804

Search NIH Clinical Center for Papillary Conjunctivitis

Genetic Tests for Papillary Conjunctivitis

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Anatomical Context for Papillary Conjunctivitis

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MalaCards organs/tissues related to Papillary Conjunctivitis:

33
Eye, Neutrophil

Animal Models for Papillary Conjunctivitis or affiliated genes

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MGI Mouse Phenotypes related to Papillary Conjunctivitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.1CCL11, CXCL8, IL4, IL6, IL7, LTF
2MP:00053876.8CCL11, CXCL8, IL4, IL6, IL7, LTF

Publications for Papillary Conjunctivitis

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Articles related to Papillary Conjunctivitis:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Risk factors for contact lens-induced papillary conjunctivitis associated with silicone hydrogel contact lens wear. (24681609)
2014
2
Comparison of tacrolimus, fluorometholone, and saline in mild-to-moderate contact lens-induced papillary conjunctivitis. (22821643)
2012
3
Comparison of olopatadine and fluorometholone in contact lens-induced papillary conjunctivitis. (20531202)
2010
4
Contact lens induced papillary conjunctivitis with silicone hydrogel lenses. (19181562)
2009
5
Giant papillary conjunctivitis. (18769199)
2008
6
Filtering bleb-induced giant papillary conjunctivitis. (17826299)
2008
7
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
8
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. (15677951)
2005
9
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. (14566648)
2003
10
General and local contact lens induced papillary conjunctivitis (CLPC). (12033982)
2002
11
Nitric oxide levels in tears of patients with mild forms of papillary conjunctivitis induced by rigid gas-permeable contact lenses. (11838991)
2002
12
Giant papillary conjunctivitis associated with an ocular prosthesis. (12366372)
2001
13
Delayed tear clearance in contact lens associated papillary conjunctivitis. (11462163)
2001
14
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study (10844086)
2000
15
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. (10703125)
1999
16
Sebaceous carcinoma presenting as a unilateral papillary conjunctivitis. (10218701)
1999
17
Giant papillary conjunctivitis--a review. (10337425)
1999
18
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. (9124242)
1997
19
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. (9001768)
1997
20
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. (8755197)
1996
21
A rare case of chronic papillary conjunctivitis diagnosed after several years of evolution. Clinical and pathological findings. (8044334)
1993
22
Causative factors in unilateral giant papillary conjunctivitis. (8495560)
1993
23
Comparison of the clinical performance of the Acuvue disposable contact lens and CSI lens in patients with giant papillary conjunctivitis. (8470716)
1993
24
N-acetyl-aspartyl glutamic acid (NAAGA) topical eyedrops in the treatment of giant papillary conjunctivitis (GPC). (7910133)
1993
25
Unusual causes of giant papillary conjunctivitis. (8458237)
1993
26
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
27
Neutrophil chemotactic factors in the tears of giant papillary conjunctivitis patients. (1846131)
1991
28
Continued contact lens wear in patients with giant papillary conjunctivitis. (1904798)
1991
29
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. (2196302)
1990
30
Giant papillary conjunctivitis. (2193971)
1990
31
Some unusual nonallergic causes of giant papillary conjunctivitis. (2095029)
1990
32
Protein and elemental analysis of contact lenses of patients with superior limbic keratoconjunctivitis or giant papillary conjunctivitis. (2717140)
1989
33
Conjunctival deposition of eosinophil granule major basic protein in vernal keratoconjunctivitis and contact lens-associated giant papillary conjunctivitis. (2750834)
1989
34
Immune responses in monkeys to lenses from patients with contact lens induced giant papillary conjunctivitis. (2917401)
1989
35
Giant papillary conjunctivitis associated with rigid gas permeable contact lenses. (3208429)
1988
36
Giant papillary conjunctivitis. (3053490)
1988
37
Papillary conjunctivitis induced by an epithelialized corneal foreign body. (3362510)
1988
38
A review of contact lens induced giant papillary conjunctivitis. (3336050)
1988
39
Giant papillary conjunctivitis. (3949453)
1986
40
Giant papillary conjunctivitis from an exposed prolene suture. (3756614)
1986
41
Suture barb giant papillary conjunctivitis. (6709289)
1984
42
Giant papillary conjunctivitis following cataract extraction. (6367598)
1984
43
Tear immunoglobulins in giant papillary conjunctivitis induced by contact lenses. (6702985)
1984
44
Clinical aspects of giant papillary conjunctivitis. (7339618)
1981
45
Percentage of degranulated mast cells in vernal conjunctivitis and giant papillary conjunctivitis associated with contact-lens wear. (7234932)
1981
46
Giant papillary conjunctivitis after keratoplasty. (7008616)
1981
47
Giant papillary conjunctivitis with ocular prostheses. (7362515)
1980
48
Giant papillary conjunctivitis: an overview. (448014)
1979
49
Giant papillary conjunctivitis and ptosis in a contact lens wearer. (458521)
1979
50
Epidemic keratoconjunctivitis and chronic papillary conjunctivitis in London due to adenovirus type 19. (191054)
1977

Variations for Papillary Conjunctivitis

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Expression for genes affiliated with Papillary Conjunctivitis

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Search GEO for disease gene expression data for Papillary Conjunctivitis.

Pathways for genes affiliated with Papillary Conjunctivitis

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Pathways related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CCL11, IL4
29.1IL4, IL6
39.1IL4, IL6
49.0CXCL8, IL6
59.0CXCL8, IL6
69.0CXCL8, IL6
79.0CXCL8, IL6
89.0CXCL8, IL6
99.0CXCL8, IL6
108.6CCL11, CXCL8, IL6
11
Show member pathways
8.6IL4, IL6, IL7
128.6IL4, IL6, IL7
138.6IL4, IL6, IL7
14
Show member pathways
8.5CXCL8, IL4, IL6
158.5CXCL8, IL4, IL6
168.5CXCL8, IL4, IL6
17
Show member pathways
8.1CCL11, CXCL8, IL4, IL6
18
Show member pathways
7.6CCL11, CXCL8, IL4, IL6, IL7
19
Show member pathways
7.6CCL11, CXCL8, IL4, IL6, IL7
20
Show member pathways
7.6CCL11, CXCL8, IL4, IL6, IL7
21
Show member pathways
7.6CCL11, CXCL8, IL4, IL6, IL7

GO Terms for genes affiliated with Papillary Conjunctivitis

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Cellular components related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.1CCL11, CXCL8, IL4, IL6, IL7, LTF
2extracellular regionGO:00055766.8CCL11, CXCL8, IL4, IL6, IL7, LTF

Biological processes related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathwayGO:200123710.1IL4, IL7
2positive regulation of T cell differentiationGO:004558210.0IL4, IL7
3positive regulation of B cell proliferationGO:003089010.0IL4, IL7
4monocyte chemotaxisGO:00025489.8CCL11, IL6
5positive regulation of B cell activationGO:00508719.8IL4, IL6
6neutrophil chemotaxisGO:00305939.7CCL11, CXCL8
7chemokine-mediated signaling pathwayGO:00700989.7CCL11, CXCL8
8innate immune response in mucosaGO:00022279.7IL4, LTF
9defense response to protozoanGO:00428329.7IL4, IL6
10positive regulation of osteoblast differentiationGO:00456699.6IL6, LTF
11humoral immune responseGO:00069599.2IL6, IL7, LTF
12response to cytokineGO:00340979.1IL4, IL6
13chemotaxisGO:00069359.1CCL11, CXCL8, IL4
14cellular response to interleukin-1GO:00713479.0CCL11, CXCL8, IL6
15cellular response to tumor necrosis factorGO:00713568.9CCL11, CXCL8, IL6
16inflammatory responseGO:00069548.9CCL11, CXCL8, IL6
17positive regulation of T cell proliferationGO:00421028.8IL4, IL6
18negative regulation of apoptotic processGO:00430668.1IL4, IL6, IL7, LTF
19immune responseGO:00069557.8CCL11, CXCL8, IL4, IL6, IL7

Molecular functions related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor bindingGO:00051269.9IL4, IL7
2chemokine activityGO:00080099.4CCL11, CXCL8
3cytokine activityGO:00051258.8IL4, IL6, IL7
4growth factor activityGO:00080838.3IL4, IL6, IL7

Sources for Papillary Conjunctivitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet