MCID: PPL019
MIFTS: 37

Papillary Conjunctivitis malady

Eye diseases category
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Summaries for Papillary Conjunctivitis

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33MalaCards
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MalaCards: Papillary Conjunctivitis is related to conjunctivitis and vernal keratoconjunctivitis. An important gene associated with Papillary Conjunctivitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are IL4-mediated signaling events and Development IGF 1 receptor signaling. The compounds unicap and anti-histamine have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are respiratory system and hematopoietic system.

Aliases & Classifications for Papillary Conjunctivitis

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

papillary conjunctivitis 8 62


External Ids:

Disease Ontology8 DOID:2458
SNOMED-CT58 416878008
NCIt40 C35616

Related Diseases for Papillary Conjunctivitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Papillary Conjunctivitis:



Diseases related to papillary conjunctivitis

Symptoms for Papillary Conjunctivitis

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Drugs & Therapeutics for Papillary Conjunctivitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Papillary Conjunctivitis

Search NIH Clinical Center for Papillary Conjunctivitis

Genetic Tests for Papillary Conjunctivitis

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Anatomical Context for Papillary Conjunctivitis

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33MalaCards
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MalaCards organs/tissues related to Papillary Conjunctivitis:

33
Eye

Animal Models for Papillary Conjunctivitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Papillary Conjunctivitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5CCL11, CCL24, PRG2
2MP:00053977.9CCL11, CCL24, PRG2, IGHE
3MP:00053877.7IGHE, PRG2, CCL24, CCL11

Publications for Papillary Conjunctivitis

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52PubMed
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Articles related to Papillary Conjunctivitis:

(show top 50)    (show all 114)
idTitleAuthorsYear
1
Comparison of tacrolimus, fluorometholone, and saline in mild-to-moderate contact lens-induced papillary conjunctivitis. (22821643)
2012
2
Comparison of olopatadine and fluorometholone in contact lens-induced papillary conjunctivitis. (20531202)
2010
3
Contact lens induced papillary conjunctivitis with silicone hydrogel lenses. (19181562)
2009
4
Giant papillary conjunctivitis. (18769199)
2008
5
Filtering bleb-induced giant papillary conjunctivitis. (17826299)
2008
6
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
7
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. (15677951)
2005
8
Contact lens chemistry and giant papillary conjunctivitis. (12772728)
2003
9
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. (14566648)
2003
10
General and local contact lens induced papillary conjunctivitis (CLPC). (12033982)
2002
11
Nitric oxide levels in tears of patients with mild forms of papillary conjunctivitis induced by rigid gas-permeable contact lenses. (11838991)
2002
12
Giant papillary conjunctivitis associated with an ocular prosthesis. (12366372)
2001
13
Delayed tear clearance in contact lens associated papillary conjunctivitis. (11462163)
2001
14
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study (10844086)
2000
15
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. (10703125)
1999
16
Sebaceous carcinoma presenting as a unilateral papillary conjunctivitis. (10218701)
1999
17
Giant papillary conjunctivitis--a review. (10337425)
1999
18
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. (9124242)
1997
19
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. (9001768)
1997
20
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. (8755197)
1996
21
A rare case of chronic papillary conjunctivitis diagnosed after several years of evolution. Clinical and pathological findings. (8044334)
1993
22
Causative factors in unilateral giant papillary conjunctivitis. (8495560)
1993
23
N-acetyl-aspartyl glutamic acid (NAAGA) topical eyedrops in the treatment of giant papillary conjunctivitis (GPC). (7910133)
1993
24
Unusual causes of giant papillary conjunctivitis. (8458237)
1993
25
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
26
Neutrophil chemotactic factors in the tears of giant papillary conjunctivitis patients. (1846131)
1991
27
Continued contact lens wear in patients with giant papillary conjunctivitis. (1904798)
1991
28
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. (2196302)
1990
29
Giant papillary conjunctivitis. (2193971)
1990
30
Some unusual nonallergic causes of giant papillary conjunctivitis. (2095029)
1990
31
Protein and elemental analysis of contact lenses of patients with superior limbic keratoconjunctivitis or giant papillary conjunctivitis. (2717140)
1989
32
Conjunctival deposition of eosinophil granule major basic protein in vernal keratoconjunctivitis and contact lens-associated giant papillary conjunctivitis. (2750834)
1989
33
Immune responses in monkeys to lenses from patients with contact lens induced giant papillary conjunctivitis. (2917401)
1989
34
Giant papillary conjunctivitis associated with rigid gas permeable contact lenses. (3208429)
1988
35
Giant papillary conjunctivitis. (3053490)
1988
36
Papillary conjunctivitis induced by an epithelialized corneal foreign body. (3362510)
1988
37
A review of contact lens induced giant papillary conjunctivitis. (3336050)
1988
38
Giant papillary conjunctivitis. (3949453)
1986
39
Giant papillary conjunctivitis from an exposed prolene suture. (3756614)
1986
40
Suture barb giant papillary conjunctivitis. (6709289)
1984
41
Giant papillary conjunctivitis following cataract extraction. (6367598)
1984
42
Tear immunoglobulins in giant papillary conjunctivitis induced by contact lenses. (6702985)
1984
43
Clinical aspects of giant papillary conjunctivitis. (7339618)
1981
44
Percentage of degranulated mast cells in vernal conjunctivitis and giant papillary conjunctivitis associated with contact-lens wear. (7234932)
1981
45
Giant papillary conjunctivitis after keratoplasty. (7008616)
1981
46
Giant papillary conjunctivitis with ocular prostheses. (7362515)
1980
47
Giant papillary conjunctivitis: an overview. (448014)
1979
48
Giant papillary conjunctivitis and ptosis in a contact lens wearer. (458521)
1979
49
Surface morphology of giant papillary conjunctivitis in contact lens wearers. (623198)
1978
50
Epidemic keratoconjunctivitis and chronic papillary conjunctivitis in London due to adenovirus type 19. (191054)
1977

Variations for Papillary Conjunctivitis

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Expression for genes affiliated with Papillary Conjunctivitis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papillary Conjunctivitis

Search GEO for disease gene expression data for Papillary Conjunctivitis.

Pathways for genes affiliated with Papillary Conjunctivitis

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Sources:
50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 12EMD Millipore, 54R&D Systems, 55Reactome, 53QIAGEN, 30KEGG
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Pathways related to Papillary Conjunctivitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CCL11, IGHE
2
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.4CCL11, IGHE
3
Show member pathways
9.3CCL11, CCL24
4
Show member pathways
9.3CCL24, CCL11
5
Show member pathways
9.3CCL11, CCL24
6
Show member pathways
9.3CCL11, CCL24
7
Show member pathways
9.1CCL11, PRG2
8
Show member pathways
8.5PRG2, CCL24, CCL11
9
Show member pathways
8.5CCL11, CCL24, PRG2

Compounds for genes affiliated with Papillary Conjunctivitis

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Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Papillary Conjunctivitis according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1unicap459.8CCL11, IGHE
2anti-histamine459.8CCL11, IGHE
3sodium cromoglycate459.8CCL11, IGHE
4cetirizine45 29 24 1112.8IGHE, CCL11
5ketotifen45 1110.7CCL11, IGHE
6montelukast45 51 29 1112.7IGHE, CCL11
7budesonide45 51 1111.7CCL11, IGHE
8salbutamol45 51 29 24 1113.7IGHE, CCL11
9fluticasone propionate45 51 61 1112.7IGHE, CCL11
10pertussis459.6CCL11, IGHE
11ccl345 2910.5CCL24, CCL11
12prednisolone45 29 1111.5IGHE, CCL11
13ltc4459.4CCL11, PRG2
14rantes459.2CCL11, CCL24
15tarc459.2CCL11, CCL24, IGHE
16fmlp459.1CCL11, PRG2
17n acetylcysteine459.1CCL11, IGHE
18acetylcholine45 51 29 24 1113.1PRG2, IGHE
19pgd2459.0IGHE, PRG2, CCL11
20methacholine45 51 1111.0CCL11, PRG2, IGHE
21allergens459.0IGHE, PRG2, CCL11
22indomethacin45 29 61 1111.9CCL11, PRG2, IGHE
23heparin45 29 24 1111.8CCL11, PRG2, IGHE
24superoxide45 249.8PRG2, CCL24, CCL11
25retinoic acid45 249.7CCL11, PRG2, IGHE
26oxygen45 249.7CCL11, CCL24, PRG2
27histamine45 29 2410.4CCL11, CCL24, PRG2, IGHE
28actinomycin d458.4CCL11, CCL24, PRG2, IGHE

GO Terms for genes affiliated with Papillary Conjunctivitis

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16Gene Ontology
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Cellular components related to Papillary Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6CCL11, PRG2, IGHE

Biological processes related to Papillary Conjunctivitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:0482459.6CCL11, CCL24
2positive regulation of Rac GTPase activityGO:0328559.5CCL24, CCL11
3positive regulation of actin filament polymerizationGO:0308389.5CCL11, CCL24
4positive regulation of endothelial cell proliferationGO:0019389.5CCL11, CCL24
5positive regulation of angiogenesisGO:0457669.4CCL24, CCL11
6cytoskeleton organizationGO:0070109.4CCL11, CCL24
7regulation of cell shapeGO:0083609.3CCL11, CCL24
8inflammatory responseGO:0069549.3CCL11, CCL24
9chemotaxisGO:0069359.2CCL24, CCL11
10positive regulation of cell migrationGO:0303359.0CCL11, CCL24
11immune responseGO:0069558.2CCL11, CCL24, PRG2, IGHE

Molecular functions related to Papillary Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.3CCL11, CCL24

Products for genes affiliated with Papillary Conjunctivitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Papillary Conjunctivitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet