MCID: PPL019
MIFTS: 34

Papillary Conjunctivitis malady

Category: Eye diseases

Aliases & Classifications for Papillary Conjunctivitis

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Aliases & Descriptions for Papillary Conjunctivitis:

Name: Papillary Conjunctivitis 11 13 67

Classifications:



External Ids:

Disease Ontology11 DOID:2458
SNOMED-CT61 416878008
NCIt44 C35616

Summaries for Papillary Conjunctivitis

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MalaCards based summary: Papillary Conjunctivitis is related to corneal deposit and giant papillary conjunctivitis. An important gene associated with Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways are Th2 Differentiation Pathway and IL4-mediated signaling events. Affiliated tissues include eye and neutrophil.

Related Diseases for Papillary Conjunctivitis

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Diseases related to Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1corneal deposit29.7CXCL8, IL6
2giant papillary conjunctivitis12.2
3conjunctivitis10.6
4dioctophymiasis10.4CCL11, IL4
5epididymis adenocarcinoma10.4CCL11, IL4
6bacterial gastritis10.4CCL11, IL4
7intracranial hypertension10.4CCL11, IL4
8apple allergy10.4CCL11, IL4
9cervix melanoma10.4CCL11, IL4
10central nervous system origin vertigo10.4CCL11, IL4
11pituitary hypoplasia10.4CCL11, IL4
12dacryoadenitis10.4CCL11, IL4
13gait apraxia10.4CCL11, IL4
14juvenile dermatitis herpetiformis10.4CCL11, IL4
15gonadal disease10.4CCL11, CXCL8
16melanoacanthoma10.4CCL11, IL4
17non-gestational choriocarcinoma10.4CCL11, CCL2
18sarcoid meningitis10.3CCL11, IL4
19basidiobolomycosis10.3CXCL8, IL4
20gonococcal synovitis10.3CCL2, IL4
21plantar wart10.3CXCL8, IL4
22loeffler syndrome10.3CCL11, IL4
23benign fibrous mesothelioma10.3CXCL8, IL4
24cytomegalovirus retinitis10.3CCL2, CXCL8
25flinders island spotted fever10.3CCL2, CXCL8
26t-cell lymphoma 1a10.3CCL2, CXCL8
27progressive relapsing multiple sclerosis10.2CCL2, IL4
28secondary lacrimal atrophy10.2CCL2, IL4
29dengue disease10.2CCL2, IL4
30lymphocytic colitis10.2IL4, IL6
31renal cell carcinoma 410.2IL4, IL6
32louping ill10.2CCL2, CXCL8
33scn8a encephalopathy10.2IL4, IL6
34philophthalmiasis10.2IL4, IL6
35sinusitis10.2CCL2, CXCL8
36tarsal tunnel syndrome10.2CXCL8, IL6
37maligant granulosa cell tumor of ovary10.2CXCL8, IL6
38senile cataract10.2IL4, IL6
39benign adult familial myoclonic epilepsy10.2CXCL8, IL6
40antigen-peptide-transporter 2 deficiency10.2CCL2, IL6
41infancy electroclinical syndrome10.2CXCL8, IL6
42gonococcal keratitis10.2IL4, IL6
43autosomal dominant cerebellar ataxia10.2CXCL8, IL6
44skin disease10.2CXCL8, IL6
45pasteurellosis10.2CXCL8, IL6
46benign lymphoepithelial lesion of salivary gland10.2IL4, IL6
47subglottis neoplasm10.2CXCL8, IL6
48orbital periostitis10.2IL4, IL6
49opiate dependence10.2CCL2, IL6
50osteogenesis imperfecta, type x10.2CXCL8, IL6

Graphical network of the top 20 diseases related to Papillary Conjunctivitis:



Diseases related to papillary conjunctivitis

Symptoms for Papillary Conjunctivitis

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Drugs & Therapeutics for Papillary Conjunctivitis

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Drugs for Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LoteprednolapprovedPhase 45082034-46-6, 129260-79-3444025, 9865442
Synonyms:
82034-46-6
AC1L9FKJ
AKOS005145741
Alrex
Alrex, Lotemax, Loteprednol etabonate
CDDD-5604
CHEBI:31784
CHEMBL1200865
CID444025
CPD000469178
D01689
DB00873
HGP-1
HMS2051F16
IDR-90102
IDR-90103
Locort
 
Loteflam
Lotemax
Lotemax (TN)
Loteprednol
Loteprednol Etabonate
Loteprednol etabonate
Loteprednol etabonate (JAN/USAN)
Loteprednolum
Loterox
MLS001424221
MolPort-003-848-424
NCGC00164594-01
P-5604
S1669_Selleck
SAM001246630
SMR000469178
ZINC03920673
chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
chloromethyl 17alpha-[(ethoxycarbonyl)oxy]-11beta-hydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylate
2Anti-Allergic AgentsPhase 41490
3Histamine H1 AntagonistsPhase 4782
4Histamine AntagonistsPhase 4946

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5%Unknown statusNCT01437982Phase 4
2Bepreve vs. Alrex in Subjects With Moderate to Severe Allergic ConjunctivitisCompletedNCT01443442Phase 4
3Clinical Performance of a New Daily Disposable Contact Lens Worn in a Neophyte Population.CompletedNCT00708032
4BIOCLEAN FIRST CARE EX in Combination With Biofinity LensCompletedNCT02196766
5Clinical Performance of Atypical Contact Lens Powers on Subjects With AstigmatismCompletedNCT00697190
6Assessment of Daily Disposable Silicone Hydrogel Lens WearCompletedNCT01093625
7Daily Disposable Silicone Hydrogel Contact Lens, Stenfilcon A, Clinical StudyCompletedNCT02637804
8Perforated Punctal Plugs for Treatment of Papillary Conjunctivitis in Otherwise Healthy PatientsRecruitingNCT02503956

Search NIH Clinical Center for Papillary Conjunctivitis

Genetic Tests for Papillary Conjunctivitis

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Anatomical Context for Papillary Conjunctivitis

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MalaCards organs/tissues related to Papillary Conjunctivitis:

35
Eye, Neutrophil

Animal Models for Papillary Conjunctivitis or affiliated genes

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Publications for Papillary Conjunctivitis

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Articles related to Papillary Conjunctivitis:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Giant papillary conjunctivitis. (18769199)
2008
2
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. (18216583)
2008
3
Papillary conjunctivitis associated with Kikuchi disease. (18724159)
2008
4
Two presentations of contact lens-induced papillary conjunctivitis (CLPC) in hydrogel lens wear: local and general. (16432470)
2006
5
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. (15677951)
2005
6
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. (14566648)
2003
7
Nitric oxide levels in tears of patients with mild forms of papillary conjunctivitis induced by rigid gas-permeable contact lenses. (11838991)
2002
8
Contact lens-induced papillary conjunctivitis is associated with increased albumin deposits on extended wear hydrogel lenses. (12614016)
2002
9
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. (10703125)
1999
10
Sebaceous carcinoma presenting as a unilateral papillary conjunctivitis. (10218701)
1999
11
Giant papillary conjunctivitis--a review. (10337425)
1999
12
Giant papillary conjunctivitis in frequent replacement contact lens wearers: a retrospective study. (10444049)
1999
13
Effect of lodoxamide on tear leukotriene levels in giant papillary conjunctivitis associated with ocular prosthesis. (9785608)
1998
14
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. (9001768)
1997
15
Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. (7586473)
1995
16
A rare case of chronic papillary conjunctivitis diagnosed after several years of evolution. Clinical and pathological findings. (8044334)
1993
17
Unusual causes of giant papillary conjunctivitis. (8458237)
1993
18
Meibomian gland function and giant papillary conjunctivitis. (8420368)
1993
19
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
20
Evaluation of tear protein deposits on contact lenses from patients with and without giant papillary conjunctivitis. (1499118)
1992
21
Immunoglobulin deposition on soft contact lenses: relationship to hydrogel structure and mode of use and giant papillary conjunctivitis. (2407379)
1990
22
Giant papillary conjunctivitis associated with elevated corneal deposits. (1706653)
1990
23
Conjunctival deposition of eosinophil granule major basic protein in vernal keratoconjunctivitis and contact lens-associated giant papillary conjunctivitis. (2750834)
1989
24
Immune responses in monkeys to lenses from patients with contact lens induced giant papillary conjunctivitis. (2917401)
1989
25
Papillary conjunctivitis induced by an epithelialized corneal foreign body. (3362510)
1988
26
A review of contact lens induced giant papillary conjunctivitis. (3336050)
1988
27
Suprofen treatment of contact lens-associated giant papillary conjunctivitis. (3211485)
1988
28
Tear lysozyme and lactoferrin levels in giant papillary conjunctivitis and vernal conjunctivitis. (3147820)
1988
29
Giant papillary conjunctivitis associated with an extruded scleral buckle. Case report. (3619733)
1987
30
Giant papillary conjunctivitis. (3949453)
1986
31
Giant papillary conjunctivitis. (3771999)
1986
32
Suture barb giant papillary conjunctivitis. (6709289)
1984
33
Giant papillary conjunctivitis following cataract extraction. (6367598)
1984
34
Giant papillary conjunctivitis in connection with corneoscleral supramid (nylon) suture knots. (6720279)
1984
35
Treatment of contact lens-induced giant papillary conjunctivitis. (6439429)
1984
36
Transient ptosis secondary to giant papillary conjunctivitis in a hydrogel lens patient. (6643895)
1983
37
Percentage of degranulated mast cells in vernal conjunctivitis and giant papillary conjunctivitis associated with contact-lens wear. (7234932)
1981
38
Giant papillary conjunctivitis after keratoplasty. (7008616)
1981
39
Giant papillary conjunctivitis. (7239822)
1981
40
The clinical management of giant papillary conjunctivitis. (7304717)
1981
41
Mast cell ultrastructure. Comparison in contact lens-associated giant papillary conjunctivitis and vernal conjunctivitis. (7259602)
1981
42
Density of goblet cells in vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis. (7236092)
1981
43
Giant papillary conjunctivitis. (6934657)
1980
44
Giant papillary conjunctivitis: an overview. (448014)
1979
45
Vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis compared and contrasted. (443320)
1979
46
Russell bodies in contact-lens-associated giant papillary conjunctivitis. (217320)
1979
47
Giant papillary conjunctivitis with ocular prostheses. (444123)
1979
48
Giant papillary conjunctivitis induced by hard or soft contact lens wear: quantitative histology. (714378)
1978
49
Giant papillary conjunctivitis (secondary vernal) in association with contact lens wear. (285506)
1978
50
Epidemic keratoconjunctivitis and chronic papillary conjunctivitis in London due to adenovirus type 19. (191054)
1977

Variations for Papillary Conjunctivitis

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Expression for genes affiliated with Papillary Conjunctivitis

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Search GEO for disease gene expression data for Papillary Conjunctivitis.

Pathways for genes affiliated with Papillary Conjunctivitis

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Pathways related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 32)
idSuper pathwaysScoreTop Affiliating Genes
19.6CCL11, IL4
29.6CCL11, IL4
39.5CCL11, CCL2
4
Show member pathways
9.4CCL2, CXCL8
59.4IL4, IL6
69.4IL4, IL6
79.3CXCL8, IL6
89.3CXCL8, IL6
99.3CXCL8, IL6
109.3CXCL8, IL6
11
Show member pathways
9.0CCL11, CCL2, CXCL8
128.9CCL11, CXCL8, IL6
138.9CXCL8, IL4, IL6
14
Show member pathways
8.9CXCL8, IL4, IL6
15
Show member pathways
8.8CCL2, CXCL8, IL6
168.8CCL2, CXCL8, IL6
178.8CCL2, CXCL8, IL6
188.8CCL2, CXCL8, IL6
198.8CCL2, CXCL8, IL6
208.6IL4, IL6, IL7
218.6IL4, IL6, IL7
228.6IL4, IL6, IL7
23
Show member pathways
8.5CCL11, CXCL8, IL4, IL6
248.4CCL2, CXCL8, IL4, IL6
25
Show member pathways
8.4CCL2, CXCL8, IL4, IL6
26
Show member pathways
7.1CCL11, CCL2, CXCL8, IL4, IL6, IL7
27
Show member pathways
7.1CCL11, CCL2, CXCL8, IL4, IL6, IL7
28
Show member pathways
7.1CCL11, CCL2, CXCL8, IL4, IL6, IL7
297.1CCL11, CCL2, CXCL8, IL4, IL6, IL7
30
Show member pathways
7.1CCL11, CCL2, CXCL8, IL4, IL6, IL7
31
Show member pathways
7.1CCL11, CCL2, CXCL8, IL4, IL6, IL7
32
Show member pathways
7.1CCL11, CCL2, CXCL8, IL4, IL6, IL7

GO Terms for genes affiliated with Papillary Conjunctivitis

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Cellular components related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.3CCL11, CCL2, CXCL8, IL6, IL7
2extracellular spaceGO:00056157.1CCL11, CCL2, CXCL8, IL4, IL6, IL7

Biological processes related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell activationGO:005087110.1IL4, IL6
2positive regulation of endothelial cell proliferationGO:000193810.0CCL11, CCL2
3lymphocyte chemotaxisGO:004824710.0CCL11, CCL2
4cellular response to interferon-gammaGO:007134610.0CCL11, CCL2
5regulation of vascular endothelial growth factor productionGO:001057410.0CCL2, IL6
6defense response to protozoanGO:004283210.0IL4, IL6
7response to amino acidGO:00432009.9CCL2, IL6
8response to cytokineGO:00340979.8IL4, IL6
9positive regulation of B cell proliferationGO:00308909.8IL4, IL7
10PERK-mediated unfolded protein responseGO:00364999.8CCL2, CXCL8
11response to bacteriumGO:00096179.8CCL2, IL6
12positive regulation of T cell proliferationGO:00421029.8IL4, IL6
13response to antibioticGO:00466779.7CCL2, IL6
14negative regulation of extrinsic apoptotic signaling pathwayGO:20012379.7IL4, IL7
15cellular response to fibroblast growth factor stimulusGO:00443449.7CCL2, CXCL8
16positive regulation of T cell differentiationGO:00455829.7IL4, IL7
17response to heatGO:00094089.5CCL2, IL6
18monocyte chemotaxisGO:00025489.5CCL11, CCL2, IL6
19cellular response to dexamethasone stimulusGO:00715499.5CCL2, IL6
20neutrophil chemotaxisGO:00305939.5CCL11, CCL2, CXCL8
21chemokine-mediated signaling pathwayGO:00700989.4CCL11, CCL2, CXCL8
22cellular response to lipopolysaccharideGO:00712229.3CCL2, CXCL8, IL6
23regulation of cell shapeGO:00083609.2CCL11, CCL2, IL6
24humoral immune responseGO:00069599.1CCL2, IL6, IL7
25cellular response to interleukin-1GO:00713478.9CCL11, CCL2, CXCL8, IL6
26response to drugGO:00424938.9CCL2, IL4, IL6
27chemotaxisGO:00069358.8CCL11, CCL2, CXCL8, IL4
28cellular response to tumor necrosis factorGO:00713568.8CCL11, CCL2, CXCL8, IL6
29inflammatory responseGO:00069548.7CCL11, CCL2, CXCL8, IL6
30positive regulation of ERK1 and ERK2 cascadeGO:00703748.6CCL11, CCL2, IL6

Molecular functions related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080098.9CCL11, CCL2, CXCL8
2growth factor activityGO:00080838.6IL4, IL6, IL7
3cytokine activityGO:00051257.8CCL2, IL4, IL6, IL7

Sources for Papillary Conjunctivitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet