MCID: PPL019
MIFTS: 35

Papillary Conjunctivitis malady

Categories: Eye diseases

Aliases & Classifications for Papillary Conjunctivitis

Aliases & Descriptions for Papillary Conjunctivitis:

Name: Papillary Conjunctivitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2458
NCIt 47 C35616
SNOMED-CT 64 416878008
UMLS 69 C0854165

Summaries for Papillary Conjunctivitis

MalaCards based summary : Papillary Conjunctivitis is related to giant papillary conjunctivitis and conjunctivitis. An important gene associated with Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Loteprednol and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye and neutrophil.

Related Diseases for Papillary Conjunctivitis

Diseases related to Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
id Related Disease Score Top Affiliating Genes
1 giant papillary conjunctivitis 12.2
2 conjunctivitis 10.6
3 anterior dislocation of lens 10.2 CCL11 IL4
4 thelaziasis 10.2 CCL11 IL4
5 lymphoblastic leukemia 10.2 CCL11 IL4
6 isthmus cancer 10.2 CCL11 IL4
7 cerebral primitive neuroectodermal tumor 10.2 CCL11 IL4
8 apricot allergy 10.2 CCL11 IL4
9 trachea leiomyoma 10.2 CCL11 IL4
10 visceral steatosis 10.2 CCL11 IL4
11 cutaneous fibrous histiocytoma 10.2 CCL11 IL4
12 lymphocytic gastritis 10.2 CCL11 IL4
13 microglandular adenosis of breast 10.2 CCL11 CXCL8
14 hidradenitis suppurativa 10.2 CCL11 CXCL8
15 intravascular angioleiomyoma 10.2 CCL11 IL4
16 ethmoid sinusitis 10.2 CCL11 IL4
17 parkinson disease 11 10.2 CCL11 CXCL8
18 conidiobolomycosis 10.2 CXCL8 IL4
19 inflamed seborrheic keratosis 10.2 CCL11 IL4
20 chancroid 10.2 CXCL8 IL4
21 breast intracanalicular fibroadenoma 10.2 CXCL8 IL4
22 barbiturate abuse 10.2 CCL11 IL4
23 coronary arterial fistulas 10.2 CXCL8 LTF
24 scleroderma, familial progressive 10.1 CXCL8 LTF
25 handl syndrome 10.1 CXCL8 LTF
26 fibrosclerosis of breast 10.1 IL4 IL7
27 sclerosing cholangitis 10.1 CXCL8 LTF
28 opitz-kaveggia syndrome 10.1 IL4 IL7
29 latent syphilis 10.1 CCL11 IL6
30 entropion 10.1 CXCL8 LTF
31 clostridium difficile colitis 10.1 IL4 IL6
32 childhood malignant mesenchymoma 10.0 CCL11 IL6
33 oculomotor nerve paralysis 10.0 CXCL8 IL6
34 common peroneal nerve lesion 10.0 CXCL8 IL6
35 neonatal hypoxic and ischemic brain injury 10.0 CXCL8 IL6
36 thymic neuroendocrine carcinoma 10.0 CXCL8 IL6
37 schwannoma of ureter 10.0 CXCL8 IL6
38 gonococcal endophthalmia 10.0 IL4 IL6
39 childhood electroclinical syndrome 10.0 CXCL8 IL6
40 ectodermal dysplasia bartalos type 10.0 IL4 IL6
41 hydrophthalmos 10.0 CCL11 CXCL8 IL4
42 eyelid neoplasm 10.0 CCL11 CXCL8 IL4
43 patellar tendinitis 10.0 CCL11 CXCL8 IL4
44 acquired polycythemia 10.0 CCL11 CXCL8 IL4
45 tracheitis 10.0 CCL11 CXCL8 IL4
46 immune-complex glomerulonephritis 10.0 IL4 IL6
47 labyrinthine bilateral reactive loss 10.0 CXCL8 IL6
48 xanthogranulomatous cholecystitis 10.0 CCL11 CXCL8 IL4
49 esophagus lymphoma 10.0 CXCL8 IL6
50 spontaneous ocular nystagmus 10.0 CCL11 CXCL8 IL4

Graphical network of the top 20 diseases related to Papillary Conjunctivitis:



Diseases related to Papillary Conjunctivitis

Symptoms & Phenotypes for Papillary Conjunctivitis

Drugs & Therapeutics for Papillary Conjunctivitis

Drugs for Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved Phase 4 82034-46-6, 129260-79-3 444025 9865442
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Anti-Allergic Agents Phase 4
5 Histamine Antagonists Phase 4
6 Histamine H1 Antagonists Phase 4
7 Antiemetics Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Antineoplastic Agents, Hormonal Phase 4
10 Autonomic Agents Phase 4
11 Gastrointestinal Agents Phase 4
12 glucocorticoids Phase 4
13 Hormone Antagonists Phase 4
14 Hormones Phase 4
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
16 Methylprednisolone acetate Phase 4
17 Methylprednisolone Hemisuccinate Phase 4
18 Neuroprotective Agents Phase 4
19 Peripheral Nervous System Agents Phase 4
20 Prednisolone acetate Phase 4
21 Prednisolone hemisuccinate Phase 4
22 Prednisolone phosphate Phase 4
23 Protective Agents Phase 4
24 Pharmaceutical Solutions

Interventional clinical trials:


id Name Status NCT ID Phase
1 Bepreve vs. Alrex in Subjects With Moderate to Severe Allergic Conjunctivitis Completed NCT01443442 Phase 4
2 A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5% Active, not recruiting NCT01437982 Phase 4
3 Clinical Performance of a New Daily Disposable Contact Lens Worn in a Neophyte Population. Completed NCT00708032
4 BIOCLEAN FIRST CARE EX in Combination With Biofinity Lens Completed NCT02196766
5 Clinical Performance of Atypical Contact Lens Powers on Subjects With Astigmatism Completed NCT00697190
6 Assessment of Daily Disposable Silicone Hydrogel Lens Wear Completed NCT01093625
7 The Clinical Performance of the Biofinity Contact Lens (Comfilcon A) With Two Lens Care Systems Completed NCT02510820
8 Daily Disposable Silicone Hydrogel Contact Lens, Stenfilcon A, Clinical Study Completed NCT02637804
9 Perforated Punctal Plugs for Treatment of Papillary Conjunctivitis in Otherwise Healthy Patients Recruiting NCT02503956

Search NIH Clinical Center for Papillary Conjunctivitis

Genetic Tests for Papillary Conjunctivitis

Anatomical Context for Papillary Conjunctivitis

MalaCards organs/tissues related to Papillary Conjunctivitis:

39
Eye, Neutrophil

Publications for Papillary Conjunctivitis

Articles related to Papillary Conjunctivitis:

(show top 50) (show all 117)
id Title Authors Year
1
Risk factors for contact lens-induced papillary conjunctivitis associated with silicone hydrogel contact lens wear. ( 24681609 )
2014
2
Comparison of tacrolimus, fluorometholone, and saline in mild-to-moderate contact lens-induced papillary conjunctivitis. ( 22821643 )
2012
3
Comparison of olopatadine and fluorometholone in contact lens-induced papillary conjunctivitis. ( 20531202 )
2010
4
Contact lens induced papillary conjunctivitis with silicone hydrogel lenses. ( 19181562 )
2009
5
Filtering bleb-induced giant papillary conjunctivitis. ( 17826299 )
2008
6
Papillary conjunctivitis associated with Kikuchi disease. ( 18724159 )
2008
7
Giant papillary conjunctivitis. ( 18769199 )
2008
8
Giant papillary conjunctivitis. ( 18282547 )
2008
9
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. ( 18216583 )
2008
10
IgE antibody on worn highly oxygen-permeable silicone hydrogel contact lenses from patients with contact lens-induced papillary conjunctivitis (CLPC). ( 18327049 )
2008
11
Immunohistochemical findings in prosthesis-associated giant papillary conjunctivitis. ( 17760635 )
2007
12
M cells are involved in pathogenesis of human contact lens-associated giant papillary conjunctivitis. ( 17557145 )
2007
13
Two presentations of contact lens-induced papillary conjunctivitis (CLPC) in hydrogel lens wear: local and general. ( 16432470 )
2006
14
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. ( 16767372 )
2006
15
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. ( 15677951 )
2005
16
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. ( 14566648 )
2003
17
Contact lens chemistry and giant papillary conjunctivitis. ( 12772728 )
2003
18
Contact lens-induced papillary conjunctivitis is associated with increased albumin deposits on extended wear hydrogel lenses. ( 12614016 )
2002
19
General and local contact lens induced papillary conjunctivitis (CLPC). ( 12033982 )
2002
20
Nitric oxide levels in tears of patients with mild forms of papillary conjunctivitis induced by rigid gas-permeable contact lenses. ( 11838991 )
2002
21
Delayed tear clearance in contact lens associated papillary conjunctivitis. ( 11462163 )
2001
22
Giant papillary conjunctivitis associated with an ocular prosthesis. ( 12366372 )
2001
23
Meibomian gland status and prevalence of giant papillary conjunctivitis in contact lens wearers. ( 15326900 )
2000
24
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study ( 10844086 )
2000
25
Giant papillary conjunctivitis in frequent replacement contact lens wearers: a retrospective study. ( 10444049 )
1999
26
Giant papillary conjunctivitis--a review. ( 10337425 )
1999
27
Sebaceous carcinoma presenting as a unilateral papillary conjunctivitis. ( 10218701 )
1999
28
Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. ( 10410873 )
1999
29
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. ( 10703125 )
1999
30
Effect of lodoxamide on tear leukotriene levels in giant papillary conjunctivitis associated with ocular prosthesis. ( 9785608 )
1998
31
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. ( 9001768 )
1997
32
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. ( 9124242 )
1997
33
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. ( 8755197 )
1996
34
Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. ( 7586473 )
1995
35
Effect of extended wear disposable contact lenses on tear LTC4 in giant papillary conjunctivitis. ( 22827277 )
1995
36
Localised giant papillary conjunctivitis secondary to a dermolipoma. ( 7556754 )
1995
37
Contact lens type, material, and deposits and giant papillary conjunctivitis. ( 7712614 )
1995
38
Giant papillary conjunctivitis. ( 7886881 )
1994
39
Bilateral giant papillary conjunctivitis related to glaucoma drainage surgery blebs. ( 7995075 )
1994
40
N-acetyl-aspartyl glutamic acid (NAAGA) topical eyedrops in the treatment of giant papillary conjunctivitis (GPC). ( 7910133 )
1993
41
Nedocromil sodium in contact-lens-associated papillary conjunctivitis. ( 8253222 )
1993
42
Meibomian gland function and giant papillary conjunctivitis. ( 8420368 )
1993
43
Causative factors in unilateral giant papillary conjunctivitis. ( 8495560 )
1993
44
Unusual causes of giant papillary conjunctivitis. ( 8458237 )
1993
45
Safety and efficacy of loteprednol etabonate for treatment of papillae in contact lens-associated giant papillary conjunctivitis. ( 8319490 )
1993
46
Meibomian gland function and giant papillary conjunctivitis. ( 8420369 )
1993
47
Comparison of the clinical performance of the Acuvue disposable contact lens and CSI lens in patients with giant papillary conjunctivitis. ( 8470716 )
1993
48
A rare case of chronic papillary conjunctivitis diagnosed after several years of evolution. Clinical and pathological findings. ( 8044334 )
1993
49
Evaluation of tear protein deposits on contact lenses from patients with and without giant papillary conjunctivitis. ( 1499118 )
1992
50
Treatment of giant papillary conjunctivitis with cromolyn sodium. ( 1559288 )
1992

Variations for Papillary Conjunctivitis

Expression for Papillary Conjunctivitis

Search GEO for disease gene expression data for Papillary Conjunctivitis.

Pathways for Papillary Conjunctivitis

Pathways related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 34)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 CCL11 CXCL8 IL4 IL6 IL7 LTF
2
Show member pathways
13.35 CCL11 CXCL8 IL4 IL6 IL7
3
Show member pathways
13.23 CCL11 CXCL8 IL4 IL6 IL7
4
Show member pathways
13.11 CCL11 CXCL8 IL4 IL6 IL7
5
Show member pathways
13.04 CCL11 CXCL8 IL4 IL6 IL7
6
Show member pathways
12.96 CCL11 CXCL8 IL4 IL6 IL7
7
Show member pathways
12.59 CCL11 CXCL8 IL4 IL6
8 12.34 IL4 IL6 IL7
9
Show member pathways
12.04 CCL11 CXCL8 IL4 IL6
10
Show member pathways
12 IL4 IL6 IL7
11
Show member pathways
11.94 CXCL8 IL4 IL6
12 11.78 CXCL8 IL4 IL6
13
Show member pathways
11.78 CCL11 CXCL8 IL4 IL6
14 11.75 IL4 IL6 IL7
15 11.64 IL4 IL6 IL7
16 11.55 CXCL8 IL4 IL6
17 11.51 IL4 IL6
18 11.51 CCL11 CXCL8 IL4 IL6
19 11.47 CXCL8 IL6
20 11.45 CCL11 IL4
21
Show member pathways
11.45 CXCL8 IL6
22 11.39 CXCL8 IL6
23 11.38 CXCL8 IL6
24 11.35 CXCL8 IL6
25 11.32 CXCL8 IL6
26 11.3 CXCL8 IL4 IL6
27 11.29 CCL11 IL4
28 11.15 CXCL8 IL6
29 11.06 CCL11 CXCL8 IL4 IL6
30 11.05 IL4 IL6 IL7
31 10.97 IL4 IL6 IL7
32 10.87 CXCL8 IL6
33 10.75 IL4 IL6
34 10.25 CCL11 CXCL8 IL4 IL6 IL7

GO Terms for Papillary Conjunctivitis

Cellular components related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL11 CXCL8 IL4 IL6 IL7 LTF
2 extracellular space GO:0005615 9.1 CCL11 CXCL8 IL4 IL6 IL7 LTF

Biological processes related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.72 CCL11 CXCL8 IL6
2 negative regulation of apoptotic process GO:0043066 9.62 IL4 IL6 IL7 LTF
3 chemokine-mediated signaling pathway GO:0070098 9.6 CCL11 CXCL8
4 positive regulation of B cell activation GO:0050871 9.59 IL4 IL6
5 neutrophil chemotaxis GO:0030593 9.58 CCL11 CXCL8
6 positive regulation of T cell proliferation GO:0042102 9.58 IL4 IL6
7 response to cytokine GO:0034097 9.57 IL4 IL6
8 positive regulation of osteoblast differentiation GO:0045669 9.56 IL6 LTF
9 defense response to Gram-negative bacterium GO:0050829 9.54 IL6 LTF
10 chemotaxis GO:0006935 9.54 CCL11 CXCL8 IL4
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.52 IL4 IL6
12 monocyte chemotaxis GO:0002548 9.51 CCL11 IL6
13 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.49 IL4 IL7
14 positive regulation of B cell proliferation GO:0030890 9.48 IL4 IL7
15 innate immune response in mucosa GO:0002227 9.46 IL4 LTF
16 defense response to protozoan GO:0042832 9.43 IL4 IL6
17 cellular response to tumor necrosis factor GO:0071356 9.43 CCL11 CXCL8 IL6
18 positive regulation of T cell differentiation GO:0045582 9.4 IL4 IL7
19 cellular response to interleukin-1 GO:0071347 9.33 CCL11 CXCL8 IL6
20 humoral immune response GO:0006959 9.13 IL6 IL7 LTF
21 immune response GO:0006955 9.02 CCL11 CXCL8 IL4 IL6 IL7

Molecular functions related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL11 CXCL8
2 cytokine receptor binding GO:0005126 9.16 IL4 IL7
3 growth factor activity GO:0008083 9.13 IL4 IL6 IL7
4 cytokine activity GO:0005125 9.02 CCL11 CXCL8 IL4 IL6 IL7

Sources for Papillary Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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