MCID: PPL019
MIFTS: 35

Papillary Conjunctivitis

Categories: Eye diseases

Aliases & Classifications for Papillary Conjunctivitis

MalaCards integrated aliases for Papillary Conjunctivitis:

Name: Papillary Conjunctivitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2458
NCIt 47 C35616
SNOMED-CT 64 416878008
UMLS 69 C0854165

Summaries for Papillary Conjunctivitis

MalaCards based summary : Papillary Conjunctivitis is related to giant papillary conjunctivitis and conjunctivitis. An important gene associated with Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Loteprednol and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye and neutrophil.

Related Diseases for Papillary Conjunctivitis

Diseases related to Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
id Related Disease Score Top Affiliating Genes
1 giant papillary conjunctivitis 12.2
2 conjunctivitis 10.6
3 anterior dislocation of lens 10.5 CCL11 IL4
4 dioctophymiasis 10.5 CCL11 IL4
5 epididymis adenocarcinoma 10.5 CCL11 IL4
6 apple allergy 10.5 CCL11 IL4
7 chronic cholangitis 10.5 CCL11 IL4
8 fungal gastritis 10.5 CCL11 IL4
9 trachea leiomyoma 10.5 CCL11 IL4
10 female urethral cancer 10.5 CCL11 IL4
11 fibrous histiocytoma 10.5 CCL11 IL4
12 viljoen kallis voges syndrome 10.5 CCL11 IL4
13 angiomyoma 10.5 CCL11 IL4
14 leukocyte disease 10.5 CCL11 IL4
15 inflamed seborrheic keratosis 10.5 CCL11 IL4
16 subcorneal pustular dermatosis 10.4 CCL11 IL4
17 tracheal stenosis 10.4 CCL11 IL6
18 benign mammary dysplasia 10.4 CCL11 IL4
19 lymphocytic colitis 10.4 IL4 IL6
20 phlyctenulosis 10.4 IL4 IL6
21 philophthalmiasis 10.4 IL4 IL6
22 early-onset zonular cataract 10.4 IL4 IL6
23 diffuse glomerulonephritis 10.4 IL4 IL6
24 lymph node palisaded myofibroblastoma 10.4 CCL11 CXCL8
25 hidradenitis suppurativa 10.4 CCL11 CXCL8
26 noma 10.4 IL4 IL6
27 reardon wilson cavanagh syndrome 10.4 IL4 IL6
28 ostertagiasis 10.4 IL4 IL6
29 orbital osteomyelitis 10.3 IL4 IL6
30 mikulicz disease 10.3 IL4 IL6
31 abnormal retinal correspondence 10.3 IL4 IL6
32 basidiobolomycosis 10.3 CXCL8 IL4
33 chancroid 10.3 CXCL8 IL4
34 keloids 10.3 IL11 IL6
35 acute interstitial pneumonia 10.3 IL4 IL6
36 oculomotor nerve paralysis 10.3 CXCL8 IL6
37 common peroneal nerve lesion 10.2 CXCL8 IL6
38 drug rash with eosinophilia and systemic symptoms 10.2 CXCL8 IL6
39 spirillary rat-bite fever 10.2 CXCL8 IL6
40 schwannoma of ureter 10.2 CXCL8 IL6
41 infancy electroclinical syndrome 10.2 CXCL8 IL6
42 opportunistic bacterial infectious disease 10.2 IL4 IL6
43 vulvar nodular hidradenoma 10.2 IL4 IL6
44 labyrinthine bilateral reactive loss 10.2 CXCL8 IL6
45 pasteurellosis 10.2 CXCL8 IL6
46 osteogenesis imperfecta, type x 10.2 CXCL8 IL6
47 subglottis neoplasm 10.2 CXCL8 IL6
48 bullous retinoschisis 10.2 CXCL8 IL6
49 cicatricial lagophthalmos 10.2 CXCL8 IL6
50 carbuncle 10.2 CXCL8 IL6

Graphical network of the top 20 diseases related to Papillary Conjunctivitis:



Diseases related to Papillary Conjunctivitis

Symptoms & Phenotypes for Papillary Conjunctivitis

Drugs & Therapeutics for Papillary Conjunctivitis

Drugs for Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved Phase 4 82034-46-6, 129260-79-3 444025 9865442
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Anti-Allergic Agents Phase 4
5 Histamine Antagonists Phase 4
6 Histamine H1 Antagonists Phase 4
7 Antiemetics Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Antineoplastic Agents, Hormonal Phase 4
10 Autonomic Agents Phase 4
11 Gastrointestinal Agents Phase 4
12 glucocorticoids Phase 4
13 Hormone Antagonists Phase 4
14 Hormones Phase 4
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
16 Methylprednisolone acetate Phase 4
17 Methylprednisolone Hemisuccinate Phase 4
18 Neuroprotective Agents Phase 4
19 Peripheral Nervous System Agents Phase 4
20 Prednisolone acetate Phase 4
21 Prednisolone hemisuccinate Phase 4
22 Prednisolone phosphate Phase 4
23 Protective Agents Phase 4
24 Pharmaceutical Solutions

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Bepreve vs. Alrex in Subjects With Moderate to Severe Allergic Conjunctivitis Completed NCT01443442 Phase 4 bepotastine besilate, 1.5%;Loteprednol etabonate
2 A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5% Active, not recruiting NCT01437982 Phase 4 Loteprednol Etabonate;Prednisolone Acetate 1% Oph Susp
3 Perforated Punctal Plugs for Treatment of Papillary Conjunctivitis in Otherwise Healthy Patients Completed NCT02503956
4 Clinical Performance of a New Daily Disposable Contact Lens Worn in a Neophyte Population. Completed NCT00708032
5 BIOCLEAN FIRST CARE EX in Combination With Biofinity Lens Completed NCT02196766
6 Clinical Performance of Atypical Contact Lens Powers on Subjects With Astigmatism Completed NCT00697190
7 Assessment of Daily Disposable Silicone Hydrogel Lens Wear Completed NCT01093625
8 The Clinical Performance of the Biofinity Contact Lens (Comfilcon A) With Two Lens Care Systems Completed NCT02510820
9 Daily Disposable Silicone Hydrogel Contact Lens, Stenfilcon A, Clinical Study Completed NCT02637804

Search NIH Clinical Center for Papillary Conjunctivitis

Genetic Tests for Papillary Conjunctivitis

Anatomical Context for Papillary Conjunctivitis

MalaCards organs/tissues related to Papillary Conjunctivitis:

39
Eye, Neutrophil

Publications for Papillary Conjunctivitis

Articles related to Papillary Conjunctivitis:

(show top 50) (show all 117)
id Title Authors Year
1
Risk factors for contact lens-induced papillary conjunctivitis associated with silicone hydrogel contact lens wear. ( 24681609 )
2014
2
Comparison of tacrolimus, fluorometholone, and saline in mild-to-moderate contact lens-induced papillary conjunctivitis. ( 22821643 )
2012
3
Comparison of olopatadine and fluorometholone in contact lens-induced papillary conjunctivitis. ( 20531202 )
2010
4
Contact lens induced papillary conjunctivitis with silicone hydrogel lenses. ( 19181562 )
2009
5
IgE antibody on worn highly oxygen-permeable silicone hydrogel contact lenses from patients with contact lens-induced papillary conjunctivitis (CLPC). ( 18327049 )
2008
6
Giant papillary conjunctivitis. ( 18282547 )
2008
7
Giant papillary conjunctivitis. ( 18769199 )
2008
8
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. ( 18216583 )
2008
9
Papillary conjunctivitis associated with Kikuchi disease. ( 18724159 )
2008
10
Filtering bleb-induced giant papillary conjunctivitis. ( 17826299 )
2008
11
Immunohistochemical findings in prosthesis-associated giant papillary conjunctivitis. ( 17760635 )
2007
12
M cells are involved in pathogenesis of human contact lens-associated giant papillary conjunctivitis. ( 17557145 )
2007
13
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. ( 16767372 )
2006
14
Two presentations of contact lens-induced papillary conjunctivitis (CLPC) in hydrogel lens wear: local and general. ( 16432470 )
2006
15
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. ( 15677951 )
2005
16
Contact lens chemistry and giant papillary conjunctivitis. ( 12772728 )
2003
17
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. ( 14566648 )
2003
18
Contact lens-induced papillary conjunctivitis is associated with increased albumin deposits on extended wear hydrogel lenses. ( 12614016 )
2002
19
General and local contact lens induced papillary conjunctivitis (CLPC). ( 12033982 )
2002
20
Nitric oxide levels in tears of patients with mild forms of papillary conjunctivitis induced by rigid gas-permeable contact lenses. ( 11838991 )
2002
21
Delayed tear clearance in contact lens associated papillary conjunctivitis. ( 11462163 )
2001
22
Giant papillary conjunctivitis associated with an ocular prosthesis. ( 12366372 )
2001
23
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study ( 10844086 )
2000
24
Meibomian gland status and prevalence of giant papillary conjunctivitis in contact lens wearers. ( 15326900 )
2000
25
Sebaceous carcinoma presenting as a unilateral papillary conjunctivitis. ( 10218701 )
1999
26
Giant papillary conjunctivitis in frequent replacement contact lens wearers: a retrospective study. ( 10444049 )
1999
27
Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. ( 10410873 )
1999
28
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. ( 10703125 )
1999
29
Giant papillary conjunctivitis--a review. ( 10337425 )
1999
30
Effect of lodoxamide on tear leukotriene levels in giant papillary conjunctivitis associated with ocular prosthesis. ( 9785608 )
1998
31
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. ( 9124242 )
1997
32
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. ( 9001768 )
1997
33
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. ( 8755197 )
1996
34
Localised giant papillary conjunctivitis secondary to a dermolipoma. ( 7556754 )
1995
35
Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. ( 7586473 )
1995
36
Effect of extended wear disposable contact lenses on tear LTC4 in giant papillary conjunctivitis. ( 22827277 )
1995
37
Contact lens type, material, and deposits and giant papillary conjunctivitis. ( 7712614 )
1995
38
Bilateral giant papillary conjunctivitis related to glaucoma drainage surgery blebs. ( 7995075 )
1994
39
Giant papillary conjunctivitis. ( 7886881 )
1994
40
Comparison of the clinical performance of the Acuvue disposable contact lens and CSI lens in patients with giant papillary conjunctivitis. ( 8470716 )
1993
41
Unusual causes of giant papillary conjunctivitis. ( 8458237 )
1993
42
Meibomian gland function and giant papillary conjunctivitis. ( 8420369 )
1993
43
Causative factors in unilateral giant papillary conjunctivitis. ( 8495560 )
1993
44
Safety and efficacy of loteprednol etabonate for treatment of papillae in contact lens-associated giant papillary conjunctivitis. ( 8319490 )
1993
45
A rare case of chronic papillary conjunctivitis diagnosed after several years of evolution. Clinical and pathological findings. ( 8044334 )
1993
46
N-acetyl-aspartyl glutamic acid (NAAGA) topical eyedrops in the treatment of giant papillary conjunctivitis (GPC). ( 7910133 )
1993
47
Meibomian gland function and giant papillary conjunctivitis. ( 8420368 )
1993
48
Nedocromil sodium in contact-lens-associated papillary conjunctivitis. ( 8253222 )
1993
49
Meibomian gland function and giant papillary conjunctivitis. ( 1642294 )
1992
50
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. ( 1499122 )
1992

Variations for Papillary Conjunctivitis

Expression for Papillary Conjunctivitis

Search GEO for disease gene expression data for Papillary Conjunctivitis.

Pathways for Papillary Conjunctivitis

Pathways related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 37)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 CCL11 CXCL8 IL11 IL4 IL6 IL7
2
Show member pathways
13.56 CCL11 CXCL8 IL11 IL4 IL6 IL7
3
Show member pathways
13.37 CCL11 CXCL8 IL11 IL4 IL6 IL7
4
Show member pathways
13.26 CCL11 CXCL8 IL11 IL4 IL6 IL7
5
Show member pathways
13.12 CCL11 CXCL8 IL11 IL4 IL6 IL7
6
Show member pathways
13.04 CCL11 CXCL8 IL11 IL4 IL6 IL7
7
Show member pathways
12.97 CCL11 CXCL8 IL11 IL4 IL6 IL7
8
Show member pathways
12.63 CCL11 CXCL8 IL4 IL6
9
Show member pathways
12.16 CCL11 CXCL8 IL4 IL6
10
Show member pathways
12.02 IL11 IL4 IL6 IL7
11
Show member pathways
11.98 CXCL8 IL4 IL6
12 11.84 CXCL8 IL4 IL6
13 11.77 IL11 IL4 IL6 IL7
14
Show member pathways
11.77 CCL11 CXCL8 IL11 IL4 IL6
15 11.73 CCL11 CXCL8 IL4 IL6
16 11.71 CXCL8 IL11 IL6
17 11.66 CXCL8 IL4 IL6
18 11.61 IL11 IL4 IL6 IL7
19 11.52 IL4 IL6
20 11.48 CXCL8 IL6
21 11.47 CCL11 IL4
22
Show member pathways
11.46 CXCL8 IL6
23
Show member pathways
11.42 IL11 IL6
24 11.4 CXCL8 IL6
25 11.4 CXCL8 IL4 IL6
26 11.39 CXCL8 IL6
27 11.36 CCL11 CXCL8 IL4 IL6
28 11.35 CXCL8 IL6
29 11.33 CXCL8 IL6
30 11.32 IL11 IL6
31 11.3 CCL11 IL4
32 11.19 IL4 IL6 IL7
33 11.16 CXCL8 IL6
34 10.9 CXCL8 IL6
35 10.78 IL4 IL6
36 10.73 IL11 IL4 IL6 IL7
37 10.33 CCL11 CXCL8 IL11 IL4 IL6 IL7

GO Terms for Papillary Conjunctivitis

Cellular components related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL11 CXCL8 IL11 IL4 IL6 IL7
2 extracellular space GO:0005615 9.1 CCL11 CXCL8 IL11 IL4 IL6 IL7

Biological processes related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.72 CCL11 CXCL8 IL6
2 positive regulation of cell proliferation GO:0008284 9.67 IL11 IL4 IL6 IL7
3 chemokine-mediated signaling pathway GO:0070098 9.61 CCL11 CXCL8
4 positive regulation of B cell activation GO:0050871 9.6 IL4 IL6
5 B cell differentiation GO:0030183 9.59 IL11 IL4
6 neutrophil chemotaxis GO:0030593 9.58 CCL11 CXCL8
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 IL4 IL6
8 chemotaxis GO:0006935 9.58 CCL11 CXCL8 IL4
9 positive regulation of T cell proliferation GO:0042102 9.57 IL4 IL6
10 response to cytokine GO:0034097 9.56 IL4 IL6
11 humoral immune response GO:0006959 9.54 IL6 IL7
12 monocyte chemotaxis GO:0002548 9.52 CCL11 IL6
13 positive regulation of B cell proliferation GO:0030890 9.51 IL4 IL7
14 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.49 IL4 IL7
15 negative regulation of endothelial cell apoptotic process GO:2000352 9.48 IL11 IL4
16 defense response to protozoan GO:0042832 9.46 IL4 IL6
17 positive regulation of T cell differentiation GO:0045582 9.43 IL4 IL7
18 cellular response to tumor necrosis factor GO:0071356 9.43 CCL11 CXCL8 IL6
19 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.33 IL11 IL4 IL6
20 negative regulation of hormone secretion GO:0046888 9.32 IL11 IL6
21 cellular response to interleukin-1 GO:0071347 9.13 CCL11 CXCL8 IL6
22 immune response GO:0006955 9.02 CCL11 CXCL8 IL4 IL6 IL7

Molecular functions related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL11 CXCL8
2 growth factor activity GO:0008083 9.26 IL11 IL4 IL6 IL7
3 cytokine receptor binding GO:0005126 9.16 IL4 IL7
4 cytokine activity GO:0005125 9.1 CCL11 CXCL8 IL11 IL4 IL6 IL7

Sources for Papillary Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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