MCID: PPL009
MIFTS: 27

Papillary Craniopharyngioma

Categories: Cancer diseases

Aliases & Classifications for Papillary Craniopharyngioma

MalaCards integrated aliases for Papillary Craniopharyngioma:

Name: Papillary Craniopharyngioma 12 14 69
Papillary Rathke's Pouch Tumor 12
Craniopharyngioma, Papillary 12
Craniopharyngioma Papillary 52

Classifications:



External Ids:

Disease Ontology 12 DOID:3847
MeSH 42 D003397
NCIt 47 C4725
SNOMED-CT 64 128782006 134215002
UMLS 69 C0431128

Summaries for Papillary Craniopharyngioma

MalaCards based summary : Papillary Craniopharyngioma, also known as papillary rathke's pouch tumor, is related to craniopharyngioma and sohval soffer syndrome, and has symptoms including visual disturbance An important gene associated with Papillary Craniopharyngioma is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Sertoli-Sertoli Cell Junction Dynamics and Development Slit-Robo signaling. Affiliated tissues include pituitary.

Related Diseases for Papillary Craniopharyngioma

Diseases related to Papillary Craniopharyngioma via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 craniopharyngioma 10.4
2 sohval soffer syndrome 10.0 BRAF CTNNB1
3 macrocytic anemia 10.0 BRAF CTNNB1
4 adamantinous craniopharyngioma 9.9 BRAF CTNNB1
5 arteritic anterior ischemic optic neuropathy 9.7 BRAF CTNNB1
6 germ cells tumors 9.7
7 immune system organ benign neoplasm 9.3 CTNNB1 DNAH2 DNAH7
8 male reproductive organ cancer 8.0 CTNNB1 DNAH12 DNAH2 DNAH7 TUBA4A
9 large cell medulloblastoma 7.6 BRAF CTNNB1 DNAH12 DNAH2 DNAH7 TUBA4A

Graphical network of the top 20 diseases related to Papillary Craniopharyngioma:



Diseases related to Papillary Craniopharyngioma

Symptoms & Phenotypes for Papillary Craniopharyngioma

UMLS symptoms related to Papillary Craniopharyngioma:


visual disturbance

Drugs & Therapeutics for Papillary Craniopharyngioma

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma Recruiting NCT03224767 Phase 2 Vemurafenib;Cobimetinib

Search NIH Clinical Center for Papillary Craniopharyngioma

Genetic Tests for Papillary Craniopharyngioma

Anatomical Context for Papillary Craniopharyngioma

MalaCards organs/tissues related to Papillary Craniopharyngioma:

39
Pituitary

Publications for Papillary Craniopharyngioma

Articles related to Papillary Craniopharyngioma:

(show all 25)
id Title Authors Year
1
BRAF-V600E mutant papillary craniopharyngioma dramatically responds to combination BRAF and MEK inhibitors. ( 28425764 )
2017
2
Anorexia-cachexia syndrome-like hypothalamic neuroendocrine dysfunction in a patient with a papillary craniopharyngioma. ( 28469924 )
2017
3
Recurrent papillary craniopharyngioma with BRAFV600E mutation treated with neoadjuvant-targeted therapy. ( 28918496 )
2017
4
Genomic Alterations of Adamantinomatous and Papillary Craniopharyngioma. ( 28069929 )
2017
5
MAPK pathway activation in the embryonic pituitary results in stem cell compartment expansion, differentiation defects and provides insights into the pathogenesis of papillary craniopharyngioma. ( 28506993 )
2017
6
Papillary craniopharyngioma: A clinicopathologic study of a rare entity from a major tertiary care center in Pakistan. ( 28488624 )
2017
7
Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles. ( 26927026 )
2016
8
Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy. ( 26498373 )
2016
9
BRAF V600E mutation is a useful marker for differentiating Rathke's cleft cyst with squamous metaplasia from papillary craniopharyngioma. ( 25820214 )
2015
10
ENDOCRINE TUMOURS: BRAF V600E mutations in papillary craniopharyngioma. ( 26563980 )
2015
11
BRAF V600E analysis for the differentiation of papillary craniopharyngiomas and Rathke's cleft cysts. ( 25442675 )
2015
12
Pronounced response of papillary craniopharyngioma to treatment with vemurafenib, a BRAF inhibitor. ( 26115708 )
2015
13
Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. ( 24413733 )
2014
14
BRAF V600E mutations are characteristic for papillary craniopharyngioma and may coexist with CTNNB1-mutated adamantinomatous craniopharyngioma. ( 24715106 )
2014
15
Pretreatment Diagnosis of Suprasellar Papillary Craniopharyngioma and Germ Cell Tumors of Adult Patients. ( 25339645 )
2014
16
Primary isolated cerebellopontine angle papillary craniopharyngioma. ( 22954990 )
2012
17
Intraventricular squamous papillary craniopharyngioma: report of a case with intraoperative imprint cytology. ( 16124175 )
2005
18
Metastatic papillary craniopharyngioma: case study and study of tumor angiogenesis. ( 11916504 )
2002
19
SUPRASELLAR PAPILLARY SQUAMOUS EPITHELIOMA (PAPILLARY CRANIOPHARYNGIOMA). ( 27407338 )
2001
20
Suprasellar squamous papillary craniopharyngioma: a case report. ( 11394840 )
2001
21
SUPRASELLAR PAPILLARY SQUAMOUS EPITHELIOMA (PAPILLARY CRANIOPHARYNGIOMA): Reply. ( 27407336 )
2001
22
SUPRASELLAR PAPILLARY SQUAMOUS EPITHELIOMA (PAPILLARY CRANIOPHARYNGIOMA). ( 28790684 )
2000
23
Regression of a large solid papillary craniopharyngioma following fractionated external radiotherapy. ( 10359146 )
1999
24
Papillary craniopharyngioma: a clinicopathological study of 48 cases. ( 7616262 )
1995
25
Papillary craniopharyngioma of the third ventricle--case report. ( 1283625 )
1992

Variations for Papillary Craniopharyngioma

Expression for Papillary Craniopharyngioma

Search GEO for disease gene expression data for Papillary Craniopharyngioma.

Pathways for Papillary Craniopharyngioma

GO Terms for Papillary Craniopharyngioma

Cellular components related to Papillary Craniopharyngioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.85 BRAF CTNNB1 DNAH12 DNAH2 DNAH7 TUBA4A
2 cytoskeleton GO:0005856 9.55 CTNNB1 DNAH12 DNAH2 DNAH7 TUBA4A
3 cilium GO:0005929 9.5 DNAH12 DNAH2 DNAH7
4 axonemal dynein complex GO:0005858 9.26 DNAH2 DNAH7
5 microtubule GO:0005874 9.26 DNAH12 DNAH2 DNAH7 TUBA4A
6 dynein complex GO:0030286 8.8 DNAH12 DNAH2 DNAH7

Biological processes related to Papillary Craniopharyngioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 thymus development GO:0048538 9.16 BRAF CTNNB1
2 cilium-dependent cell motility GO:0060285 8.96 DNAH2 DNAH7
3 microtubule-based movement GO:0007018 8.8 DNAH12 DNAH2 DNAH7

Molecular functions related to Papillary Craniopharyngioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.46 BRAF DNAH12 DNAH2 DNAH7
2 motor activity GO:0003774 9.13 DNAH12 DNAH2 DNAH7
3 microtubule motor activity GO:0003777 8.8 DNAH12 DNAH2 DNAH7

Sources for Papillary Craniopharyngioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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