MCID: PPL009
MIFTS: 28

Papillary Craniopharyngioma

Categories: Cancer diseases

Aliases & Classifications for Papillary Craniopharyngioma

MalaCards integrated aliases for Papillary Craniopharyngioma:

Name: Papillary Craniopharyngioma 12 14 69
Papillary Rathke's Pouch Tumor 12
Craniopharyngioma, Papillary 12
Craniopharyngioma Papillary 51

Classifications:



External Ids:

Disease Ontology 12 DOID:3847
MeSH 41 D003397
NCIt 46 C4725
SNOMED-CT 64 128782006 134215002
UMLS 69 C0431128

Summaries for Papillary Craniopharyngioma

MalaCards based summary : Papillary Craniopharyngioma, also known as papillary rathke's pouch tumor, is related to craniopharyngioma and small intestinal adenocarcinoma, and has symptoms including visual disturbance An important gene associated with Papillary Craniopharyngioma is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Glioblastoma Multiforme and Corticotropin-releasing hormone signaling pathway. Affiliated tissues include pituitary.

Related Diseases for Papillary Craniopharyngioma

Diseases related to Papillary Craniopharyngioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 craniopharyngioma 30.5 BRAF CTNNB1 KRT7
2 small intestinal adenocarcinoma 10.2 BRAF CTNNB1
3 metanephric adenoma 10.2 BRAF KRT7
4 lung acinar adenocarcinoma 10.2 CTNNB1 KRT7
5 large intestine adenocarcinoma 10.1 CTNNB1 KRT7
6 female reproductive endometrioid cancer 10.1 CTNNB1 KRT7
7 adenomyoma 10.1 CTNNB1 KRT7
8 pulmonary sclerosing hemangioma 10.1 CTNNB1 KRT7
9 sclerosing hemangioma 10.1 CTNNB1 KRT7
10 signet ring cell adenocarcinoma 10.1 CTNNB1 KRT7
11 cystitis cystica 10.1 CTNNB1 KRT7
12 colonic benign neoplasm 10.1 BRAF CTNNB1
13 acinar cell carcinoma 10.1 CTNNB1 KRT7
14 gastrointestinal system benign neoplasm 10.1 CTNNB1 KRT7
15 organ system benign neoplasm 10.1 CTNNB1 KRT7
16 bladder urothelial carcinoma 10.1 BRAF KRT7
17 rectum adenocarcinoma 10.1 DNAH12 KRT7
18 cell type benign neoplasm 10.1 CTNNB1 KRT7
19 endometrial adenocarcinoma 10.1 CTNNB1 KRT7
20 ovarian cancer 1 10.1 CTNNB1 KRT7
21 papillary carcinoma 10.0 BRAF KRT7
22 sarcoma, synovial 10.0 CTNNB1 KRT7
23 mesothelioma, malignant 10.0 CTNNB1 KRT7
24 intrahepatic cholangiocarcinoma 10.0 CTNNB1 KRT7
25 gastrointestinal system cancer 9.9 CTNNB1 KRT7
26 cell type cancer 9.9 CTNNB1 KRT7
27 hepatoblastoma 9.9 CTNNB1 KRT7
28 colorectal adenocarcinoma 9.9 BRAF CTNNB1 KRT7
29 adenoma 9.8 BRAF CTNNB1 KRT7
30 lung cancer susceptibility 3 9.8 BRAF CTNNB1 KRT7
31 germ cells tumors 9.8
32 lynch syndrome 9.7 BRAF CTNNB1
33 endometrial cancer 9.5 BRAF CTNNB1 KRT7
34 central nervous system organ benign neoplasm 9.5 CTNNB1 DNAH2 DNAH7
35 adamantinous craniopharyngioma 9.1 CTNNB1 DNAH12 DNAH2 DNAH7

Graphical network of the top 20 diseases related to Papillary Craniopharyngioma:



Diseases related to Papillary Craniopharyngioma

Symptoms & Phenotypes for Papillary Craniopharyngioma

UMLS symptoms related to Papillary Craniopharyngioma:


visual disturbance

Drugs & Therapeutics for Papillary Craniopharyngioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma Recruiting NCT03224767 Phase 2 Vemurafenib;Cobimetinib

Search NIH Clinical Center for Papillary Craniopharyngioma

Genetic Tests for Papillary Craniopharyngioma

Anatomical Context for Papillary Craniopharyngioma

MalaCards organs/tissues related to Papillary Craniopharyngioma:

38
Pituitary

Publications for Papillary Craniopharyngioma

Articles related to Papillary Craniopharyngioma:

(show all 25)
# Title Authors Year
1
Anorexia-cachexia syndrome-like hypothalamic neuroendocrine dysfunction in a patient with a papillary craniopharyngioma. ( 28469924 )
2017
2
MAPK pathway activation in the embryonic pituitary results in stem cell compartment expansion, differentiation defects and provides insights into the pathogenesis of papillary craniopharyngioma. ( 28506993 )
2017
3
Recurrent papillary craniopharyngioma with BRAFV600E mutation treated with neoadjuvant-targeted therapy. ( 28918496 )
2017
4
Genomic Alterations of Adamantinomatous and Papillary Craniopharyngioma. ( 28069929 )
2017
5
Papillary craniopharyngioma: A clinicopathologic study of a rare entity from a major tertiary care center in Pakistan. ( 28488624 )
2017
6
BRAF-V600E mutant papillary craniopharyngioma dramatically responds to combination BRAF and MEK inhibitors. ( 28425764 )
2017
7
Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles. ( 26927026 )
2016
8
Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy. ( 26498373 )
2016
9
BRAF V600E mutation is a useful marker for differentiating Rathke's cleft cyst with squamous metaplasia from papillary craniopharyngioma. ( 25820214 )
2015
10
BRAF V600E analysis for the differentiation of papillary craniopharyngiomas and Rathke's cleft cysts. ( 25442675 )
2015
11
Pronounced response of papillary craniopharyngioma to treatment with vemurafenib, a BRAF inhibitor. ( 26115708 )
2015
12
ENDOCRINE TUMOURS: BRAF V600E mutations in papillary craniopharyngioma. ( 26563980 )
2015
13
BRAF V600E mutations are characteristic for papillary craniopharyngioma and may coexist with CTNNB1-mutated adamantinomatous craniopharyngioma. ( 24715106 )
2014
14
Pretreatment Diagnosis of Suprasellar Papillary Craniopharyngioma and Germ Cell Tumors of Adult Patients. ( 25339645 )
2014
15
Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. ( 24413733 )
2014
16
Primary isolated cerebellopontine angle papillary craniopharyngioma. ( 22954990 )
2012
17
Intraventricular squamous papillary craniopharyngioma: report of a case with intraoperative imprint cytology. ( 16124175 )
2005
18
Metastatic papillary craniopharyngioma: case study and study of tumor angiogenesis. ( 11916504 )
2002
19
SUPRASELLAR PAPILLARY SQUAMOUS EPITHELIOMA (PAPILLARY CRANIOPHARYNGIOMA): Reply. ( 27407336 )
2001
20
Suprasellar squamous papillary craniopharyngioma: a case report. ( 11394840 )
2001
21
SUPRASELLAR PAPILLARY SQUAMOUS EPITHELIOMA (PAPILLARY CRANIOPHARYNGIOMA). ( 27407338 )
2001
22
SUPRASELLAR PAPILLARY SQUAMOUS EPITHELIOMA (PAPILLARY CRANIOPHARYNGIOMA). ( 28790684 )
2000
23
Regression of a large solid papillary craniopharyngioma following fractionated external radiotherapy. ( 10359146 )
1999
24
Papillary craniopharyngioma: a clinicopathological study of 48 cases. ( 7616262 )
1995
25
Papillary craniopharyngioma of the third ventricle--case report. ( 1283625 )
1992

Variations for Papillary Craniopharyngioma

Expression for Papillary Craniopharyngioma

Search GEO for disease gene expression data for Papillary Craniopharyngioma.

Pathways for Papillary Craniopharyngioma

Pathways related to Papillary Craniopharyngioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11 BRAF CTNNB1
2 10.59 BRAF CTNNB1

GO Terms for Papillary Craniopharyngioma

Cellular components related to Papillary Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.62 CTNNB1 DNAH12 DNAH2 DNAH7
2 microtubule GO:0005874 9.43 DNAH12 DNAH2 DNAH7
3 cilium GO:0005929 9.33 DNAH12 DNAH2 DNAH7
4 axonemal dynein complex GO:0005858 8.96 DNAH2 DNAH7
5 dynein complex GO:0030286 8.8 DNAH12 DNAH2 DNAH7

Biological processes related to Papillary Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thymus development GO:0048538 9.16 BRAF CTNNB1
2 cilium-dependent cell motility GO:0060285 8.96 DNAH2 DNAH7
3 microtubule-based movement GO:0007018 8.8 DNAH12 DNAH2 DNAH7

Molecular functions related to Papillary Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.71 BRAF DNAH12 DNAH2 DNAH7
2 dynein light intermediate chain binding GO:0051959 9.37 DNAH2 DNAH7
3 dynein intermediate chain binding GO:0045505 9.32 DNAH2 DNAH7
4 dynein light chain binding GO:0045503 9.26 DNAH2 DNAH7
5 ATP-dependent microtubule motor activity, minus-end-directed GO:0008569 9.16 DNAH2 DNAH7
6 motor activity GO:0003774 9.13 DNAH12 DNAH2 DNAH7
7 microtubule motor activity GO:0003777 8.8 DNAH12 DNAH2 DNAH7

Sources for Papillary Craniopharyngioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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