MCID: PPL009
MIFTS: 30

Papillary Craniopharyngioma malady

Categories: Cancer diseases

Aliases & Classifications for Papillary Craniopharyngioma

Aliases & Descriptions for Papillary Craniopharyngioma:

Name: Papillary Craniopharyngioma 12 14 69
Papillary Rathke's Pouch Tumor 12
Craniopharyngioma, Papillary 12
Craniopharyngioma Papillary 52

Classifications:



External Ids:

Disease Ontology 12 DOID:3847
MeSH 42 D003397
NCIt 47 C4725
SNOMED-CT 64 128782006 134215002
UMLS 69 C0431128

Summaries for Papillary Craniopharyngioma

MalaCards based summary : Papillary Craniopharyngioma, also known as papillary rathke's pouch tumor, is related to craniopharyngioma and spastic diplegia infantile type, and has symptoms including visual disturbance An important gene associated with Papillary Craniopharyngioma is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Sertoli-Sertoli Cell Junction Dynamics and Development Slit-Robo signaling. The drugs Fentanyl and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include pituitary.

Related Diseases for Papillary Craniopharyngioma

Diseases related to Papillary Craniopharyngioma via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 craniopharyngioma 10.4
2 spastic diplegia infantile type 10.0 BRAF CTNNB1
3 oral squamous cell carcinoma 9.9 BRAF CTNNB1
4 bone benign neoplasm 9.7 CTNNB1 DNAH2 DNAH7
5 large cell medulloblastoma 9.2 CTNNB1 DNAH12 DNAH2 DNAH7 TUBA4A
6 cerebellar vermis medulloblastoma 9.1 BRAF CTNNB1 DNAH12 DNAH2 DNAH7 TUBA4A

Graphical network of the top 20 diseases related to Papillary Craniopharyngioma:



Diseases related to Papillary Craniopharyngioma

Symptoms & Phenotypes for Papillary Craniopharyngioma

UMLS symptoms related to Papillary Craniopharyngioma:


visual disturbance

Drugs & Therapeutics for Papillary Craniopharyngioma

Drugs for Papillary Craniopharyngioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Donepezil Approved Phase 3 120014-06-4 3152
3 Adjuvants, Anesthesia Phase 3
4 Analgesics Phase 3
5 Analgesics, Opioid Phase 3
6 Anesthetics Phase 3
7 Anesthetics, General Phase 3
8 Anesthetics, Intravenous Phase 3
9 Central Nervous System Depressants Phase 3
10 Liver Extracts Phase 3,Phase 1
11 Narcotics Phase 3
12 pancreatic polypeptide Phase 3
13 Peripheral Nervous System Agents Phase 3
14 Cholinergic Agents Phase 3
15 Cholinesterase Inhibitors Phase 3
16 Neurotransmitter Agents Phase 3
17 Nootropic Agents Phase 3
18 Cola Nutraceutical Phase 3,Phase 1
19
Trioxsalen Approved Phase 1 3902-71-4 5585
20
Verteporfin Approved, Investigational Phase 1 129497-78-5
21
Dacarbazine Approved, Investigational Phase 1 4342-03-4 5351166
22
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
23
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
24 Dermatologic Agents Phase 1
25 Dihematoporphyrin Ether Phase 1
26 Photosensitizing Agents Phase 1
27 Alkylating Agents Phase 1
28 Antineoplastic Agents, Alkylating Phase 1
29 Anticonvulsants Phase 1
30
Entinostat Phase 1
31 Histone Deacetylase Inhibitors Phase 1
32 Hormones

Interventional clinical trials:


id Name Status NCT ID Phase
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
2 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3
3 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1
4 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1
5 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1
6 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1
7 Study of Tissue Samples From Patients With Glioma or Other Brain Tumors Completed NCT00967200
8 Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
9 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671
10 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Papillary Craniopharyngioma

Genetic Tests for Papillary Craniopharyngioma

Anatomical Context for Papillary Craniopharyngioma

MalaCards organs/tissues related to Papillary Craniopharyngioma:

39
Pituitary

Publications for Papillary Craniopharyngioma

Articles related to Papillary Craniopharyngioma:

(show all 23)
id Title Authors Year
1
MAPK pathway activation in the embryonic pituitary results in stem cell compartment expansion, differentiation defects and provides insights into the pathogenesis of papillary craniopharyngioma. ( 28506993 )
2017
2
Anorexia-cachexia syndrome-like hypothalamic neuroendocrine dysfunction in a patient with a papillary craniopharyngioma. ( 28469924 )
2017
3
Papillary craniopharyngioma: A clinicopathologic study of a rare entity from a major tertiary care center in Pakistan. ( 28488624 )
2017
4
Genomic Alterations of Adamantinomatous and Papillary Craniopharyngioma. ( 28069929 )
2017
5
BRAF-V600E mutant papillary craniopharyngioma dramatically responds to combination BRAF and MEK inhibitors. ( 28425764 )
2017
6
Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy. ( 26498373 )
2016
7
Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles. ( 26927026 )
2016
8
BRAF V600E analysis for the differentiation of papillary craniopharyngiomas and Rathke's cleft cysts. ( 25442675 )
2015
9
BRAF V600E mutation is a useful marker for differentiating Rathke's cleft cyst with squamous metaplasia from papillary craniopharyngioma. ( 25820214 )
2015
10
ENDOCRINE TUMOURS: BRAF V600E mutations in papillary craniopharyngioma. ( 26563980 )
2015
11
Pronounced response of papillary craniopharyngioma to treatment with vemurafenib, a BRAF inhibitor. ( 26115708 )
2015
12
Pretreatment Diagnosis of Suprasellar Papillary Craniopharyngioma and Germ Cell Tumors of Adult Patients. ( 25339645 )
2014
13
Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. ( 24413733 )
2014
14
BRAF V600E mutations are characteristic for papillary craniopharyngioma and may coexist with CTNNB1-mutated adamantinomatous craniopharyngioma. ( 24715106 )
2014
15
Primary isolated cerebellopontine angle papillary craniopharyngioma. ( 22954990 )
2012
16
Intraventricular squamous papillary craniopharyngioma: report of a case with intraoperative imprint cytology. ( 16124175 )
2005
17
Metastatic papillary craniopharyngioma: case study and study of tumor angiogenesis. ( 11916504 )
2002
18
Suprasellar squamous papillary craniopharyngioma: a case report. ( 11394840 )
2001
19
SUPRASELLAR PAPILLARY SQUAMOUS EPITHELIOMA (PAPILLARY CRANIOPHARYNGIOMA). ( 27407338 )
2001
20
SUPRASELLAR PAPILLARY SQUAMOUS EPITHELIOMA (PAPILLARY CRANIOPHARYNGIOMA): Reply. ( 27407336 )
2001
21
Regression of a large solid papillary craniopharyngioma following fractionated external radiotherapy. ( 10359146 )
1999
22
Papillary craniopharyngioma: a clinicopathological study of 48 cases. ( 7616262 )
1995
23
Papillary craniopharyngioma of the third ventricle--case report. ( 1283625 )
1992

Variations for Papillary Craniopharyngioma

Expression for Papillary Craniopharyngioma

Search GEO for disease gene expression data for Papillary Craniopharyngioma.

Pathways for Papillary Craniopharyngioma

GO Terms for Papillary Craniopharyngioma

Cellular components related to Papillary Craniopharyngioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.85 BRAF CTNNB1 DNAH12 DNAH2 DNAH7 TUBA4A
2 cytoskeleton GO:0005856 9.55 CTNNB1 DNAH12 DNAH2 DNAH7 TUBA4A
3 cilium GO:0005929 9.5 DNAH12 DNAH2 DNAH7
4 axonemal dynein complex GO:0005858 9.26 DNAH2 DNAH7
5 microtubule GO:0005874 9.26 DNAH12 DNAH2 DNAH7 TUBA4A
6 dynein complex GO:0030286 8.8 DNAH12 DNAH2 DNAH7

Biological processes related to Papillary Craniopharyngioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 thymus development GO:0048538 9.16 BRAF CTNNB1
2 cilium-dependent cell motility GO:0060285 8.96 DNAH2 DNAH7
3 microtubule-based movement GO:0007018 8.8 DNAH12 DNAH2 DNAH7

Molecular functions related to Papillary Craniopharyngioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.46 BRAF DNAH12 DNAH2 DNAH7
2 motor activity GO:0003774 9.13 DNAH12 DNAH2 DNAH7
3 microtubule motor activity GO:0003777 8.8 DNAH12 DNAH2 DNAH7

Sources for Papillary Craniopharyngioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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