MCID: PPL005
MIFTS: 48

Papillary Renal Cell Carcinoma malady

Nephrological, Cancer, Genetic categories

Summaries for Papillary Renal Cell Carcinoma

Sources:
8Disease Ontology, 47OMIM, 33MalaCards
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Disease Ontology:8 Papillary renal cell carcinoma is a renal cell carcinoma characterized as the second most common type of renal cell carcinoma. the cancerous cells form some projections in a finger shape, called papillae, in the tumor. this type of cancer is more common among african americans and has a good prognosis if treated with surgery in its early stages.

MalaCards: Papillary Renal Cell Carcinoma, also known as renal cell carcinoma, papillary, is related to papillary carcinoma and renal clear cell carcinoma. An important gene associated with Papillary Renal Cell Carcinoma is PRCC (papillary renal cell carcinoma (translocation-associated)), and among its related pathways is Pathways in cancer. The compounds paraffin and oligonucleotide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and brain, and related mouse phenotype normal.

Description from OMIM:47 605074

Aliases & Classifications for Papillary Renal Cell Carcinoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 9diseasecard, 47OMIM, 35MeSH, 40NCIt, 57SNOMED-CT, 26ICD10 via Orphanet, 36MESH via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer, Genetic
Anatomical: Nephrological


Characteristics (Orphanet epidemiological data):

49
familial papillary renal cell carcinoma:
Inheritance: Autosomal dominant; Age of onset: Adulthood


Aliases & Descriptions:

papillary renal cell carcinoma 8 43 10 49 61
renal cell carcinoma, papillary 9 47
papillary renal cell carcinoma, bilateral - 43
papillary renal cell carcinoma, familial - 43
papillary renal cell carcinoma, sporadic - 43
papillary renal cell carcinoma, multiple - 43
papillary renal cell carcinoma, familial 61
papillary renal cell carcinoma, sporadic 61
sporadic papillary renal cell carcinoma 8
familial papillary renal cell carcinoma 49
papillary renal carcinoma, malignant - 43
papillary renal cell adenocarcinoma 49
chromophil carcinoma of kidney 8


External Ids:

Disease Ontology8 DOID:4465
OMIM47 605074
NCIt40 C6975
SNOMED-CT57 4797003
ICD10 via Orphanet26 C64
MESH via Orphanet36 C538614
UMLS via Orphanet62 C2931899

Related Diseases for Papillary Renal Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Papillary Renal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1papillary carcinoma32.0MET, AMACR, KRT7
2renal clear cell carcinoma31.4KRT7, MET, CDH16, VHL, AMACR
3papillary adenoma31.0PRCC
4adenoma31.0VHL, FIGF, AMACR, KRT7, MMP11, MET
5metanephric adenoma30.8KRT7
6angiomyolipoma30.7MITF
7renal cell carcinoma, papillary, 130.6PRCC, TFE3
8wilms tumor30.2AMACR, KRT7, VHL
9adenocarcinoma30.2FIGF, MET, VHL, KRT7, MMP11, AMACR
10papillary renal carcinoma11.4
11clear cell renal cell carcinoma11.0
12spindle cell carcinoma10.5
13renal cell carcinoma, clear cell, somatic10.5
14small cell carcinoma10.4
15gastrointestinal stromal tumor10.4
16hereditary leiomyomatosis and renal cell cancer10.4
17tubulocystic carcinoma10.4
18familial renal papillary carcinoma10.3
19polycystic kidney disease10.3
20large cell carcinoma10.3
21autosomal dominant disease10.3
22polycystic kidney disease, autosomal dominant10.3
23chromophobe renal cell carcinoma10.3
24familial renal cell carcinoma10.3
25renal cell carcinoma, papillary, 1, familial and somatic10.3
26crescentic glomerulonephritis10.2
27renal wilms' tumor10.2
28parathyroid carcinoma10.2
29xanthogranulomatous pyelonephritis10.2
30collecting duct carcinoma10.2
31nonpapillary renal cell carcinoma10.2
32adenoid cystic carcinoma10.2
33t cell deficiency10.2
34pten hamartoma tumor syndrome10.2
35cerebellar degeneration10.2
36horseshoe kidney10.2
37retroperitoneal fibrosis10.2
38hypoxia10.2
39renal cell carcinoma, somatic10.2
40renal cell carcinoma, papillary, 310.2
41teratoma10.2
42kidney rhabdoid cancer10.0RNF139
43nephrogenic adenoma10.0KRT7, AMACR
44alveolar soft part sarcoma10.0TFE3, PRCC
45leukemia10.0SAGE1, TFE3
46hepatitis10.0AMACR
47renal oncocytoma10.0KRT7, CDH16, PRCC
48endometrial carcinoma10.0FIGF, KRT7
49sarcoma10.0MET, MMP11, TFE3
50oxyphilic adenoma10.0VHL, AMACR, CDH16, KRT7

Graphical network of the top 20 diseases related to Papillary Renal Cell Carcinoma:



Diseases related to papillary renal cell carcinoma

Clinical Features for Papillary Renal Cell Carcinoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

605074

Drugs & Therapeutics for Papillary Renal Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Papillary Renal Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Papillary Renal Cell Carcinoma

Search NIH Clinical Center for Papillary Renal Cell Carcinoma

Search CenterWatch for Papillary Renal Cell Carcinoma

Genetic Tests for Papillary Renal Cell Carcinoma

Anatomical Context for Papillary Renal Cell Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Papillary Renal Cell Carcinoma:

33
Bone marrow, Lymph node, Brain, Smooth muscle, Small intestine, Kidney, Thyroid, T cells, B cells, Endothelial

Animal Models for Papillary Renal Cell Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Papillary Renal Cell Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.0NONO, CDR2, MITF, FIGF, MET, TFE3

Publications for Papillary Renal Cell Carcinoma

Sources:
51PubMed
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Articles related to Papillary Renal Cell Carcinoma:

(show top 50)    (show all 284)
idTitleAuthorsYear
1
Tumor-associated macrophages are involved in tumor progression in papillary renal cell carcinoma. (24327306)
2013
2
Metastatic papillary thyroid carcinoma to the kidney: report of two cases mimicking primary renal cell carcinoma and review of the literature. (23255036)
2013
3
A novel oncocytoid papillary renal cell carcinoma, type 2, with aberrant cytogenetic abnormalities: oncocytic papillary renal cell carcinoma? (23635826)
2013
4
Renal cell carcinoma with areas mimicking renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma. (23434146)
2013
5
Differentiation of papillary renal cell carcinoma subtypes on CT and MRI. (23883215)
2013
6
Chromosome 7 aneuploidy in clear cell and papillary renal cell carcinoma: detection using silver in situ hybridization technique. (24056643)
2013
7
Initial clinical sensitivity and acquired resistance to MET inhibition in MET-mutated papillary renal cell carcinoma. (23610116)
2013
8
Clear cell renal cell carcinoma and papillary renal cell carcinoma: differentiation of distinct histological types with multiphase CT. (23864331)
2013
9
Hereditary papillary renal cell carcinoma primarily diagnosed in a cervical lymph node: a case report of a 30-year-old woman with multiple metastases. (23320739)
2013
10
Metanephric adenoma and solid variant of papillary renal cell carcinoma: common and distinctive features. (23551615)
2013
11
Tumour-associated macrophages might represent a favourable prognostic indicator in patients with papillary renal cell carcinoma. (23802739)
2013
12
Expression of parafibromin in clear cell papillary renal cell carcinoma. (23060304)
2013
13
Renal metanephric adenoma mimicking papillary renal cell carcinoma on computed tomography: a case report. (23076029)
2013
14
Clear cell papillary renal cell carcinoma-like tumors in patients with von Hippel-Lindau disease are unrelated to sporadic clear cell papillary renal cell carcinoma. (23648463)
2013
15
Clear cell papillary renal cell carcinoma: a report of 15 cases including three cases of concurrent other-type renal cell carcinomas. (23323104)
2012
16
Clear cell papillary renal cell carcinoma with characteristic morphology and immunohistochemical staining pattern. (22931041)
2012
17
Clear cell, papillary and chromophobe renal cell carcinoma in patients younger than 20 years old: a clinicopathologic study with follow-up. (22018933)
2012
18
Fuhrman grade provides higher prognostic accuracy than nucleolar grade for papillary renal cell carcinoma. (20399450)
2010
19
Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response. (19581925)
2009
20
Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors. (19724685)
2009
21
Brain metastasis of a papillary renal cell carcinoma, identified as type 2. (19593623)
2009
22
Prognostic factors in a prospective series of papillary renal cell carcinoma. (18489525)
2008
23
Re: efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. (18485320)
2008
24
Prognostic value of morphologic subdivision of papillary renal cell carcinoma and MUC1 expression]. (18986629)
2008
25
Papillary renal cell carcinoma with oncocytic cells and nonoverlapping low grade nuclei: expanding the morphologic spectrum with emphasis on clinicopathologic, immunohistochemical and molecular features. (17949780)
2008
26
Papillary renal cell carcinoma: a clinicopathological study of 35 cases. (16903928)
2006
27
A molecular classification of papillary renal cell carcinoma. (15994935)
2005
28
Papillary renal cell carcinoma in allograft kidney. (15378336)
2005
29
Eosinophilic cytoplasmic inclusions in papillary renal cell carcinoma. (16378236)
2005
30
Papillary renal cell carcinoma in a child. (15543486)
2004
31
Prognostic factors for the survival of patients with papillary renal cell carcinoma: meaning of histological typing and multifocality. (12913693)
2003
32
The largest reported papillary renal cell carcinoma. (15736367)
2002
33
Biological significance of c-met over expression in papillary renal cell carcinoma. (12050491)
2002
34
Bilateral papillary renal cell carcinoma. (11218021)
2001
35
Morphologic typing of papillary renal cell carcinoma: comparison of growth kinetics and patient survival in 66 cases. (11431713)
2001
36
Papillary renal-cell carcinoma demonstrating prominent foamy macrophages by cytobrush scrapings: a case report. (10945914)
2000
37
Papillary renal cell carcinoma with clear cell cytomorphology and chromosomal loss of 3p. (10460661)
1999
38
A case report of renal abscess caused by Salmonella virchow phage type 1 associated with a papillary renal cell carcinoma. (10090513)
1999
39
Papillary (chromophil) renal cell carcinoma with mucinous secretion. (10048089)
1999
40
Cytologic analysis of papillary renal cell carcinoma. (9801205)
1998
41
Mucin secretion in papillary (chromophil) renal cell carcinoma. (9706987)
1998
42
Paraneoplastic opsoclonus associated with papillary renal cell carcinoma. (9436748)
1998
43
Overexpression of c-met proto-oncogene associated with chromophilic renal cell carcinoma with papillary growth. (9870683)
1998
44
Simultaneous chromosome 7 and 17 gain and sex chromosome loss provide evidence that renal metanephric adenoma is related to papillary renal cell carcinoma. (9224305)
1997
45
A study of papillary renal cell carcinoma. Clinicopathological, immunohistochemical features and its typing]. (9234615)
1997
46
Fine mapping of the 1q21 breakpoint of the papillary renal cell carcinoma-associated (X;1) translocation. (8682500)
1996
47
Molecular cloning of the papillary renal cell carcinoma-associated translocation (X;1)(p11;q21) breakpoint. (8995477)
1996
48
Cytogenetic characterization of a familial papillary renal cell carcinoma. (8536226)
1995
49
A case of papillary renal cell carcinoma suggestive of Bellini duct origin. (8191972)
1994
50
Papillary renal cell carcinoma. A morphologic and cytogenetic study of 11 cases. (2913826)
1989

Genetic Variations for Papillary Renal Cell Carcinoma

Sources:
63UniProtKB/Swiss-Prot
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Genetic disease variations for Papillary Renal Cell Carcinoma:

63 (show all 15)
id Symbol AA change Variation SNP ID
1METp.Met1131ThrVAR_006286
2METp.Val1188LeuVAR_006287
3METp.Leu1195ValVAR_006288
4METp.Val1220IleVAR_006289
5METp.Asp1228AsnVAR_006290
6METp.Asp1228HisVAR_006291
7METp.Tyr1230CysVAR_006292
8METp.Tyr1230HisVAR_006293
9METp.Met1250ThrVAR_006294
10METp.Val1092IleVAR_032485
11METp.His1094LeuVAR_032486
12METp.His1094ArgVAR_032487
13METp.His1094TyrVAR_032488
14METp.His1106AspVAR_032489
15METp.Tyr1230AspVAR_032491

Expression for genes affiliated with Papillary Renal Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papillary Renal Cell Carcinoma

Search GEO for disease gene expression data for Papillary Renal Cell Carcinoma.

Pathways for genes affiliated with Papillary Renal Cell Carcinoma

Sources:
30KEGG
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Pathways related to Papillary Renal Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2MITF, FIGF, MET, VHL

Compounds for genes affiliated with Papillary Renal Cell Carcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR
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Compounds related to Papillary Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1paraffin4510.2AMACR, MET, MITF, MMP11, KRT7
2oligonucleotide4510.1VHL, AMACR, SAGE1, MET, MITF, MMP11
3testosterone45 60 11 2413.1AMACR, SFPQ, MET, KRT7, NONO
4progesterone45 60 29 11 2414.1KRT7, MMP11, FIGF, IGFBP6, MET, SFPQ
5vegf4510.1MET, FIGF, MMP11, KRT7, VHL
6fumarate45 1111.1AMACR, VHL
7tyrosine459.9VHL, AMACR, MET, IGFBP6, FIGF, MITF

GO Terms for genes affiliated with Papillary Renal Cell Carcinoma

Sources:
16Gene Ontology
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Cellular components related to Papillary Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1paraspecklesGO:04238210.3NONO, SFPQ

Biological processes related to Papillary Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of osteoclast differentiationGO:04567010.3MITF, TFE3

Molecular functions related to Papillary Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.6NONO, SFPQ, MET, AKR1B10, PRCC, TBC1D25

Products for genes affiliated with Papillary Renal Cell Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Papillary Renal Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet