RCCP
MCID: PPL005
MIFTS: 62

Papillary Renal Cell Carcinoma (RCCP) malady

Genetic diseases, Rare diseases, Nephrological diseases, Cancer diseases categories

Summaries for Papillary Renal Cell Carcinoma

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OMIM:46 Hereditary papillary renal cell carcinoma is characterized by the development of multiple, bilateral papillary renal... (605074) more...

MalaCards based summary: Papillary Renal Cell Carcinoma, also known as renal cell carcinoma, papillary, is related to metanephric adenoma and papillary adenoma, and has symptoms including autosomal dominant inheritance, incomplete penetrance and papillary renal cell carcinoma. An important gene associated with Papillary Renal Cell Carcinoma is PRCC (papillary renal cell carcinoma (translocation-associated)), and among its related pathways are Regulation of retinoblastoma protein and Renal cell carcinoma. The drugs hydroxyurea and interferon alfa-2a and the compounds fumarate and oligonucleotide have been mentioned in the context of this disorder. Affiliated tissues include kidney, thyroid and brain, and related mouse phenotypes are craniofacial and mortality/aging.

Disease Ontology:9 A renal cell carcinoma that is characterized by the development of multiple, bilateral papillary renal tumors.

Aliases & Classifications for Papillary Renal Cell Carcinoma

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Sources:
31LifeMap Discovery®, 9Disease Ontology, 10diseasecard, 42NIH Rare Diseases, 21GeneTests, 46OMIM, 11DISEASES, 48Orphanet, 61UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD10 via Orphanet, 62UMLS via Orphanet, 35MESH via Orphanet
See all sources

Papillary Renal Cell Carcinoma, Aliases & Descriptions:

Name: Papillary Renal Cell Carcinoma 31 9 42 11 48 61
Renal Cell Carcinoma, Papillary 10 46
Chromophil Carcinoma of Kidney 9 61
Papillary Kidney Carcinoma 9 21
Papillary Renal Cell Carcinoma, Bilateral - 42
Papillary Renal Cell Carcinoma, Multiple - 42
Papillary Renal Cell Carcinoma, Sporadic - 42
Papillary Renal Cell Carcinoma, Familial - 42
Papillary Renal Cell Carcinoma, Sporadic 61
 
Papillary Renal Cell Carcinoma, Familial 61
Familial Papillary Renal Cell Carcinoma 48
Sporadic Papillary Renal Cell Carcinoma 9
Papillary Renal Carcinoma, Malignant - 42
Papillary Renal Cell Adenocarcinoma 48
Adenocarcinoma, Renal 61
Renal Adenocarcinoma 42
Rccp 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
familial papillary renal cell carcinoma:
Inheritance: Autosomal dominant; Age of onset: Adulthood


External Ids:

Disease Ontology9 DOID:4465
OMIM46 605074
NCIt39 C6975
SNOMED-CT56 4797003
ICD10 via Orphanet27 C64
UMLS via Orphanet62 C1306837, C2931899
MESH via Orphanet35 C538614

Related Diseases for Papillary Renal Cell Carcinoma

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Diseases in the Papillary Renal Cell Carcinoma family:

Renal Cell Carcinoma, Papillary, 1

Diseases related to Papillary Renal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1metanephric adenoma31.6KRT7
2papillary adenoma31.3PRCC
3cystadenoma31.0KRT7
4renal oncocytoma31.0CDH16, KRT7, PRCC
5synovial sarcoma30.0MET, KRT7
6kidney cancer29.0MET, AMACR, CDH16, KRT7, PRCC, FH
7renal cell carcinoma11.4
8clear cell papillary renal cell carcinoma11.0
9adenoma10.7
10clear cell renal cell carcinoma10.6
11spindle cell carcinoma10.5
12angiomyolipoma10.5
13hereditary leiomyomatosis and renal cell cancer10.5
14renal cell carcinoma, clear cell, somatic10.5
15mucinous tubular and spindle cell carcinoma10.5
16gastrointestinal stromal tumor10.5
17kidney disease10.5
18thyroiditis10.5
19tubulocystic carcinoma10.5
20chordoma10.4KRT7
21alveolar soft part sarcoma10.4PRCC, TFE3
22von hippel-lindau disease10.4
23polycystic kidney disease10.4
24pyelonephritis10.4
25renal cell carcinoma, papillary, 1, familial and somatic10.4
26renal cell carcinoma, papillary, 110.4
27endotheliitis10.4
28nephrogenic adenoma10.3AMACR, KRT7
29perivascular epithelioid cell tumor10.3MITF, TFE3
30barrett's esophagus10.3AMACR, KRT7
31chromophobe renal cell carcinoma10.2
32glomerulonephritis10.2
33wilms tumor10.2
34crescentic glomerulonephritis10.2
35adenoiditis10.2
36collecting duct carcinoma10.2
37xanthogranulomatous pyelonephritis10.2
38adenocarcinoma10.2
39cervicitis10.2
40cystic kidney10.2
41glomerulosclerosis10.2
42leiomyomatosis10.2
43lipomatosis10.2
44lymphopenia10.2
45nephroblastoma10.2
46neuropathy10.2
47vaginitis10.2
48pten hamartoma tumor syndrome10.2
49castleman's disease10.2
50cerebellar degeneration10.2

Graphical network of the top 20 diseases related to Papillary Renal Cell Carcinoma:



Diseases related to papillary renal cell carcinoma

Symptoms for Papillary Renal Cell Carcinoma

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Clinical features from OMIM:

605074

HPO human phenotypes related to Papillary Renal Cell Carcinoma:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 incomplete penetrance HP:0003829
3 papillary renal cell carcinoma HP:0006766

Drugs & Therapeutics for Papillary Renal Cell Carcinoma

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Genetic Tests for Papillary Renal Cell Carcinoma

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Genetic tests related to Papillary Renal Cell Carcinoma:

id Genetic test Affiliating Genes
1 Papillary Renal Carcinoma21 MET

Anatomical Context for Papillary Renal Cell Carcinoma

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MalaCards organs/tissues related to Papillary Renal Cell Carcinoma:

32
Kidney, Thyroid, Brain, Endothelial, Bone, Lymph node, Smooth muscle, Small intestine, Testes

Animal Models for Papillary Renal Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Papillary Renal Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.0MITF, MET, SCHIP1, TFE3
2MP:00107687.7FH, TFE3, SFPQ, SCHIP1, AMACR, MET

Publications for Papillary Renal Cell Carcinoma

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Articles related to Papillary Renal Cell Carcinoma:

(show top 50)    (show all 265)
idTitleAuthorsYear
1
Urologic Pathology: CBS25-1 CLEAR CELL PAPILLARY RENAL CELL CARCINOMA. (25188173)
2014
2
Clear cell papillary renal cell carcinoma is the fourth most common histologic type of renal cell carcinoma in 290 consecutive nephrectomies for renal cell carcinoma. (24182559)
2014
3
Papillary renal cell carcinoma: current progress and future directions. (24629521)
2014
4
Clear cell papillary renal cell carcinoma with angiomyomatous stroma: a histological, immunohistochemical, and fluorescence in situ hybridization study. (24771120)
2014
5
Clear cell papillary renal cell carcinoma: micro-RNA expression profiling and comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma. (24703100)
2014
6
Tumor-associated macrophages are involved in tumor progression in papillary renal cell carcinoma. (24327306)
2013
7
Gene expression profiling of clear cell papillary renal cell carcinoma: comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma. (23887297)
2013
8
Gastrointestinal stromal tumor of small intestine and synchronous bilateral papillary renal cell carcinoma. (24195178)
2013
9
Prognostic implications of the magnetic resonance imaging appearance in papillary renal cell carcinoma. (22903703)
2013
10
Bilateral papillary renal cell carcinoma and angiomyolipoma in the patients with autosomal dominant polycystic kidney disease: case report of two cases and literature review. (24375046)
2013
11
Comparison of the 2002 and 2010 TNM classification systems regarding outcome prediction in clear cell and papillary renal cell carcinoma. (23020176)
2013
12
A novel oncocytoid papillary renal cell carcinoma, type 2, with aberrant cytogenetic abnormalities: oncocytic papillary renal cell carcinoma? (23635826)
2013
13
Renal replacement lipomatosis with coexistent papillary renal cell carcinoma, renal tubulopapillary adenomatosis, and xanthogranulomatous pyelonephritis: an extremely rare association and possible pathogenetic correlation. (23801477)
2013
14
Renal-cell carcinomas in end-stage kidneys: a clinicopathological study with emphasis on clear-cell papillary renal-cell carcinoma and acquired cystic kidney disease-associated carcinoma. (21791489)
2012
15
Papillary renal cell carcinoma in the transplanted kidney - a case report focusing on contrast enhanced ultrasound features. (22957332)
2012
16
Clear cell papillary renal cell carcinoma: a report of 15 cases including three cases of concurrent other-type renal cell carcinomas. (23323104)
2012
17
A case of ossifying papillary renal cell carcinoma. (22748893)
2012
18
Clear cell papillary renal cell carcinoma in the bilateral native kidneys after 2a88years of renal transplantation: report of a case and review of the literature. (23198258)
2011
19
Papillary renal cell carcinoma with extensive paraaortic nodal metastasis mimicking malignant lymphoma. (21960003)
2011
20
Case of hereditary papillary renal cell carcinoma. (23882344)
2011
21
Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2. (22014567)
2011
22
Tubulocystic carcinoma of kidney associated with papillary renal cell carcinoma. (21393894)
2011
23
Paraneoplastic optic neuropathy associated with papillary renal cell carcinoma. (19515641)
2010
24
The utility of PAX-2 and renal cell carcinoma marker immunohistochemistry in distinguishing papillary renal cell carcinoma from nonrenal cell neoplasms with papillary features. (21102195)
2010
25
Papillary renal cell carcinoma with diffuse clear cells and thyroid-like macrofollicular areas. (20637436)
2010
26
Typical signs of oncocytic papillary renal cell carcinoma in everyday clinical praxis. (20454896)
2010
27
Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response. (19581925)
2009
28
Is there a role of the histologic subtypes of papillary renal cell carcinoma as a prognostic factor? (19586962)
2009
29
Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors. (19724685)
2009
30
Prognostic factors in a prospective series of papillary renal cell carcinoma. (18489525)
2008
31
Differentiation of pathologic subtypes of papillary renal cell carcinoma on CT. (18941101)
2008
32
Differential expression of prognostic markers in histological subtypes of papillary renal cell carcinoma. (18422770)
2008
33
Coexistence of papillary renal cell carcinoma and gastrointestinal stromal tumor in a case. (17450496)
2007
34
Role of PSF-TFE3 oncoprotein in the development of papillary renal cell carcinomas. (16832349)
2007
35
Papillary renal cell carcinoma within a renal oncocytoma: case report of an incidental finding of a tumour within a tumour. (17405978)
2007
36
Detection of DNA copy number changes and oncogenic signaling abnormalities from gene expression data reveals MYC activation in high-grade papillary renal cell carcinoma. (17409424)
2007
37
Synchronous collecting duct carcinoma and papillary renal cell carcinoma: a case report and review of the literature. (15816631)
2005
38
Expression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma. (14707866)
2004
39
Papillary renal cell carcinoma in a child. (15543486)
2004
40
The largest reported papillary renal cell carcinoma. (15736367)
2002
41
Bilateral papillary renal cell carcinoma. (11218021)
2001
42
Genomic structure, chromosomal localization, and embryonic expression of the mouse homolog of PRCC, a gene associated with papillary renal cell carcinoma. (11435707)
2001
43
Papillary renal cell carcinoma presenting as nodal metastases to the neck. (10746990)
1999
44
Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. (9195569)
1997
45
Simultaneous chromosome 7 and 17 gain and sex chromosome loss provide evidence that renal metanephric adenoma is related to papillary renal cell carcinoma. (9224305)
1997
46
Mutation of the VHL gene is associated exclusively with the development of non-papillary renal cell carcinomas. (8758207)
1996
47
Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas. (8986805)
1996
48
Mapping the X chromosome breakpoint in two papillary renal cell carcinoma cell lines with a t(X;1)(p11.2;q21.2) and the first report of a female case. (7587394)
1995
49
Nonpapillary and papillary renal cell carcinoma: a cytogenetic and phenotypic study. (8415591)
1993
50
Papillary renal cell carcinoma six years after renal cystectomy. (1274012)
1976

Variations for Papillary Renal Cell Carcinoma

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UniProtKB/Swiss-Prot genetic disease variations for Papillary Renal Cell Carcinoma:

63 (show all 15)
id Symbol AA change Variation ID SNP ID
1METp.Met1131ThrVAR_006286
2METp.Val1188LeuVAR_006287
3METp.Leu1195ValVAR_006288
4METp.Val1220IleVAR_006289
5METp.Asp1228AsnVAR_006290
6METp.Asp1228HisVAR_006291
7METp.Tyr1230CysVAR_006292
8METp.Tyr1230HisVAR_006293
9METp.Met1250ThrVAR_006294
10METp.Val1092IleVAR_032485
11METp.His1094LeuVAR_032486
12METp.His1094ArgVAR_032487
13METp.His1094TyrVAR_032488
14METp.His1106AspVAR_032489
15METp.Tyr1230AspVAR_032491

Clinvar genetic disease variations for Papillary Renal Cell Carcinoma:

7
id Gene Name Type Significance SNP ID Assembly Location
1METNM_001127500.1(MET): c.3446T> C (p.Met1149Thr)single nucleotide variantPathogenicrs121913668GRCh37Chr 7, 116418881: 116418881
2METNM_001127500.1(MET): c.3616G> T (p.Val1206Leu)single nucleotide variantPathogenicrs121913669GRCh37Chr 7, 116422081: 116422081
3METNM_001127500.1(MET): c.3712G> A (p.Val1238Ile)single nucleotide variantPathogenicrs121913670GRCh37Chr 7, 116423383: 116423383
4METNM_001127500.1(MET): c.3736G> A (p.Asp1246Asn)single nucleotide variantPathogenicrs121913671GRCh37Chr 7, 116423407: 116423407
5METNM_001127500.1(MET): c.3743A> G (p.Tyr1248Cys)single nucleotide variantPathogenicrs121913246GRCh37Chr 7, 116423414: 116423414
6METNM_001127500.1(MET): c.3637C> G (p.Leu1213Val)single nucleotide variantPathogenicrs121913673GRCh37Chr 7, 116422102: 116422102
7METNM_001127500.1(MET): c.3335A> G (p.His1112Arg)single nucleotide variantPathogenicrs121913243GRCh37Chr 7, 116417464: 116417464

Expression for genes affiliated with Papillary Renal Cell Carcinoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Papillary Renal Cell Carcinoma patients vs. healthy controls: 31 (show all 318)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1Kidney-9.090.000
2FABP1fatty acid binding protein 1, liverKidney-8.850.000
3SLC12A1solute carrier family 12 (sodium/potassium/chloride transporter), member 1Kidney-8.840.000
4CALB1calbindin 1, 28kDaKidney-8.670.000
5SCNN1Gsodium channel, non-voltage-gated 1, gamma subunitKidney-8.580.000
6ALDOBaldolase B, fructose-bisphosphateKidney-8.530.000
7CLDN8claudin 8Kidney-8.440.000
8HPD4-hydroxyphenylpyruvate dioxygenaseKidney-8.060.000
9MUC15mucin 15, cell surface associatedKidney-7.910.000
10KNG1kininogen 1Kidney-7.820.000
11EGFepidermal growth factorKidney-7.810.000
12FXYD4FXYD domain containing ion transport regulator 4Kidney-7.680.000
13GSTA1glutathione S-transferase alpha 1Kidney-7.610.000
14NPHS2nephrosis 2, idiopathic, steroid-resistant (podocin)Kidney-7.600.000
15G6PCglucose-6-phosphatase, catalytic subunitKidney-7.500.000
16SLC7A13solute carrier family 7 (anionic amino acid transporter), member 13Kidney-7.320.000
17HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)Kidney-7.220.000
18RALYLRALY RNA binding protein-likeKidney-7.100.000
19HSD11B2hydroxysteroid (11-beta) dehydrogenase 2Kidney-7.080.000
20FAM151Afamily with sequence similarity 151, member AKidney-7.080.000
21DNASE1deoxyribonuclease IKidney-7.000.000
22TMEM52Btransmembrane protein 52BKidney-6.940.000
23KCNJ10potassium inwardly-rectifying channel, subfamily J, member 10Kidney-6.930.000
24IRX2iroquois homeobox 2Kidney-6.900.000
25PVALBparvalbuminKidney-6.660.000
26APOC1apolipoprotein C-IKidney+6.640.000
27SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3Kidney-6.600.000
28SLC26A7solute carrier family 26 (anion exchanger), member 7Kidney-6.510.000
29SLC4A1solute carrier family 4 (anion exchanger), member 1 (Diego blood group)Kidney-6.510.000
30TYRP1tyrosinase-related protein 1Kidney-6.460.000
31UPB1ureidopropionase, betaKidney-6.390.000
32CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 11Kidney-6.380.000
33SOSTsclerostinKidney-6.350.000
34HEPACAM2HEPACAM family member 2Kidney-6.330.000
35UMODuromodulinKidney-6.210.000
36SCNN1Bsodium channel, non-voltage-gated 1, beta subunitKidney-6.210.000
37SLC22A6solute carrier family 22 (organic anion transporter), member 6Kidney-6.190.000
38GCgroup-specific component (vitamin D binding protein)Kidney-6.190.000
39MFSD4major facilitator superfamily domain containing 4Kidney-6.190.000
40PDE1Aphosphodiesterase 1A, calmodulin-dependentKidney-6.180.002
41GPC5glypican 5Kidney-6.170.000
42SFRP1secreted frizzled-related protein 1Kidney-6.110.000
43MPPED2metallophosphoesterase domain containing 2Kidney-6.070.000
44HS6ST2heparan sulfate 6-O-sulfotransferase 2Kidney-6.060.004
45SLC22A8solute carrier family 22 (organic anion transporter), member 8Kidney-6.040.000
46WNK4WNK lysine deficient protein kinase 4Kidney-6.030.000
47RHCGRh family, C glycoproteinKidney-6.010.000
48CRHBPcorticotropin releasing hormone binding proteinKidney-5.990.000
49EHFets homologous factorKidney-5.980.000
50C16orf89chromosome 16 open reading frame 89Kidney-5.970.000
51DIO1deiodinase, iodothyronine, type IKidney-5.880.000
52PRDM16PR domain containing 16Kidney-5.880.000
53TMEM213transmembrane protein 213Kidney-5.850.000
54PROM2prominin 2Kidney-5.830.000
55RERGLRERG/RAS-likeKidney-5.780.000
56CLIC5chloride intracellular channel 5Kidney-5.770.000
57KCNN3potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3Kidney-5.770.000
58TNFAIP6tumor necrosis factor, alpha-induced protein 6Kidney+5.760.001
59TMPRSS2transmembrane protease, serine 2Kidney-5.750.000
60ENPP6ectonucleotide pyrophosphatase/phosphodiesterase 6Kidney-5.690.000
61GAD1glutamate decarboxylase 1 (brain, 67kDa)Kidney-5.680.000
62SLC14A1solute carrier family 14 (urea transporter), member 1 (Kidd blood group)Kidney-5.680.000
63MYH11myosin, heavy chain 11, smooth muscleKidney-5.660.000
64NELL1NEL-like 1 (chicken)Kidney-5.630.000
65LOC284578uncharacterized LOC284578Kidney-5.610.000
66ATP6V1G3ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3Kidney-5.600.000
67MUC20mucin 20, cell surface associatedKidney-5.560.000
68FAM3Bfamily with sequence similarity 3, member BKidney-5.560.000
69TMEM174transmembrane protein 174Kidney-5.550.000
70SLC4A9solute carrier family 4, sodium bicarbonate cotransporter, member 9Kidney-5.550.000
71RASD1RAS, dexamethasone-induced 1Kidney-5.550.000
72ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4Kidney-5.550.000
73SLC5A12solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12Kidney-5.540.001
74SLC22A12solute carrier family 22 (organic anion/urate transporter), member 12Kidney-5.530.000
75C1orf168chromosome 1 open reading frame 168Kidney-5.490.000
76PTGER3prostaglandin E receptor 3 (subtype EP3)Kidney-5.470.000
77SLC12A3solute carrier family 12 (sodium/chloride transporter), member 3Kidney-5.420.000
78TCF21transcription factor 21Kidney-5.410.000
79ESRRBestrogen-related receptor betaKidney-5.410.000
80CYP4A22cytochrome P450, family 4, subfamily A, polypeptide 22Kidney-5.380.000
81ALBalbuminKidney-5.370.000
82CTXN3cortexin 3Kidney-5.370.000
83C2orf40chromosome 2 open reading frame 40Kidney-5.350.000
84HAO2hydroxyacid oxidase 2 (long chain)Kidney-5.320.001
85NOS1nitric oxide synthase 1 (neuronal)Kidney-5.310.000
86EYA4eyes absent homolog 4 (Drosophila)Kidney-5.290.001
87PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Kidney-5.290.000
88FABP4fatty acid binding protein 4, adipocyteKidney-5.280.000
89MECOMMDS1 and EVI1 complex locusKidney-5.270.000
90TMEM178Atransmembrane protein 178AKidney-5.260.001
91RENreninKidney-5.260.000
92ZNF44zinc finger protein 44Kidney-5.250.000
93CRYAAcrystallin, alpha AKidney-5.240.000
94SERPINA5serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5Kidney-5.240.000
95ADH1Balcohol dehydrogenase 1B (class I), beta polypeptideKidney-5.220.000
96FGF9fibroblast growth factor 9Kidney-5.190.000
97RAB25RAB25, member RAS oncogene familyKidney-5.180.000
98UPP2uridine phosphorylase 2Kidney-5.180.001
99AQP2aquaporin 2 (collecting duct)Kidney-5.150.000
100TPCN2two pore segment channel 2Kidney-5.140.000
101NTRK2neurotrophic tyrosine kinase, receptor, type 2Kidney-5.120.001
102ATP6V1B1ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1Kidney-5.110.000
103AFMafaminKidney-5.110.000
104TBX2T-box 2Kidney-5.090.000
105STAP1signal transducing adaptor family member 1Kidney-5.070.000
106RALGAPA2Ral GTPase activating protein, alpha subunit 2 (catalytic)Kidney-5.050.000
107MMEmembrane metallo-endopeptidaseKidney-5.040.002
108AGXTalanine-glyoxylate aminotransferaseKidney-5.040.000
109ERBB4v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4Kidney-5.040.003
110SLC22A7solute carrier family 22 (organic anion transporter), member 7Kidney-5.040.001
111MT1Gmetallothionein 1GKidney-5.020.000
112TCEAL2transcription elongation factor A (SII)-like 2Kidney-4.990.000
113CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 2Kidney-4.990.000
114XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-boundKidney-4.990.000
115WT1Wilms tumor 1Kidney-4.990.000
116C7complement component 7Kidney-4.960.000
117LOC285556uncharacterized LOC285556Kidney-4.940.000
118TMEM45Btransmembrane protein 45BKidney-4.930.001
119ATP6V1C2ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2Kidney-4.920.000
120BHMTbetaine--homocysteine S-methyltransferaseKidney-4.920.001
121DUSP9dual specificity phosphatase 9Kidney-4.920.000
122TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)Kidney-4.910.000
123VAT1Lvesicle amine transport 1-likeKidney-4.910.000
124EMCNendomucinKidney-4.900.000
125TSPAN8tetraspanin 8Kidney-4.900.006
126SIM2single-minded family bHLH transcription factor 2Kidney-4.900.000
127PLGplasminogenKidney-4.890.000
128DMRT2doublesex and mab-3 related transcription factor 2Kidney-4.890.000
129KHKketohexokinase (fructokinase)Kidney-4.890.000
130HRGhistidine-rich glycoproteinKidney-4.880.000
131ACPPacid phosphatase, prostateKidney-4.860.000
132TMEM72transmembrane protein 72Kidney-4.850.000
133DACH1dachshund family transcription factor 1Kidney-4.850.001
134PTGDSprostaglandin D2 synthase 21kDa (brain)Kidney-4.830.001
135AHNAK2AHNAK nucleoprotein 2Kidney+4.830.000
136IRX1iroquois homeobox 1Kidney-4.810.000
137FOLH1folate hydrolase (prostate-specific membrane antigen) 1Kidney-4.810.000
138ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2Kidney-4.800.000
139LOC149703uncharacterized LOC149703Kidney-4.800.001
140TOP2Atopoisomerase (DNA) II alpha 170kDaKidney+4.780.001
141GATA3GATA binding protein 3Kidney-4.780.000
142FGF1fibroblast growth factor 1 (acidic)Kidney-4.760.000
143ELF5E74-like factor 5 (ets domain transcription factor)Kidney-4.760.000
144KCNE1potassium voltage-gated channel, Isk-related family, member 1Kidney-4.750.000
145SEMA3Gsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3GKidney-4.740.000
146CASRcalcium-sensing receptorKidney-4.740.001
147ANGPTL3angiopoietin-like 3Kidney-4.720.000
148SLC34A1solute carrier family 34 (type II sodium/phosphate contransporter), member 1Kidney-4.710.000
149PAHphenylalanine hydroxylaseKidney-4.710.000
150ERICH4glutamate-rich 4Kidney-4.700.000
151CLCNKBchloride channel, voltage-sensitive KbKidney-4.700.000
152TFAP2Btranscription factor AP-2 beta (activating enhancer binding protein 2 beta)Kidney-4.690.001
153SLC13A2solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2Kidney-4.680.001
154CA4carbonic anhydrase IVKidney-4.670.000
155FCN3ficolin (collagen/fibrinogen domain containing) 3Kidney-4.670.000
156TFPI2tissue factor pathway inhibitor 2Kidney+4.590.000
157SLFN13schlafen family member 13Kidney+4.520.000
158CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)Kidney+4.490.029
159VCANversicanKidney+4.450.003
160ALOX5arachidonate 5-lipoxygenaseKidney+4.430.000
161LCN2lipocalin 2Kidney+4.330.000
162LRRC20leucine rich repeat containing 20Kidney+4.250.000
163C3complement component 3Kidney+4.240.001
164ABHD11abhydrolase domain containing 11Kidney+4.000.000
165HK2hexokinase 2Kidney+3.980.000
166SEC16BSEC16 homolog B (S. cerevisiae)Kidney+3.980.000
167ABCB4ATP-binding cassette, sub-family B (MDR/TAP), member 4Kidney+3.910.002
168NRTNneurturinKidney+3.840.002
169DNM1dynamin 1Kidney+3.810.000
170LOC100289026putative uncharacterized protein FLJ00310-likeKidney+3.800.002
171HOXA1homeobox A1Kidney+3.800.000
172LYPD1LY6/PLAUR domain containing 1Kidney+3.760.019
173C3orf67chromosome 3 open reading frame 67Kidney+3.760.000
174TREM2triggering receptor expressed on myeloid cells 2Kidney+3.760.000
175HAVCR1hepatitis A virus cellular receptor 1Kidney+3.670.000
176HTRA4HtrA serine peptidase 4Kidney+3.620.002
177CXCL6chemokine (C-X-C motif) ligand 6Kidney+3.610.036
178F12coagulation factor XII (Hageman factor)Kidney+3.570.004
179BCANbrevicanKidney+3.560.001
180CCND2cyclin D2Kidney+3.550.000
181LRRN4leucine rich repeat neuronal 4Kidney+3.520.000
182C15orf48chromosome 15 open reading frame 48Kidney+3.500.015
183BRIP1BRCA1 interacting protein C-terminal helicase 1Kidney+3.500.001
184NAV3neuron navigator 3Kidney+3.480.007
185TPX2TPX2, microtubule-associatedKidney+3.420.013
186NNMTnicotinamide N-methyltransferaseKidney+3.420.004
187SCG5secretogranin V (7B2 protein)Kidney+3.380.020
188HS3ST1heparan sulfate (glucosamine) 3-O-sulfotransferase 1Kidney+3.370.004
189HIST1H2AGhistone cluster 1, H2agKidney+3.350.024
190C1orf186chromosome 1 open reading frame 186Kidney+3.320.001
191MNX1motor neuron and pancreas homeobox 1Kidney+3.240.000
192ONECUT2one cut homeobox 2Kidney+3.230.013
193CD86CD86 moleculeKidney+3.200.001
194TTKTTK protein kinaseKidney+3.190.012
195NEK2NIMA-related kinase 2Kidney+3.160.033
196KIF20Akinesin family member 20AKidney+3.140.027
197TEN1TEN1 CST complex subunitKidney+3.140.013
198TLCD2TLC domain containing 2Kidney+3.130.007
199LOC340340uncharacterized LOC340340Kidney+3.100.023
200UNC5Aunc-5 homolog A (C. elegans)Kidney+3.070.045
201FANCIFanconi anemia, complementation group IKidney+3.060.011
202CDHR1cadherin-related family member 1Kidney+3.060.026
203MIR155HGMIR155 host gene (non-protein coding)Kidney+3.040.018
204CDH6cadherin 6, type 2, K-cadherin (fetal kidney)Kidney+3.030.000
205ARL11ADP-ribosylation factor-like 11Kidney+3.030.028
206TPK1thiamin pyrophosphokinase 1Kidney+3.020.002
207BCL2A1BCL2-related protein A1Kidney+3.020.022
208LRP2BPLRP2 binding proteinKidney+2.990.013
209PLA2G7phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)Kidney+2.980.033
210TEAD4TEA domain family member 4Kidney+2.980.001
211NAPSBnapsin B aspartic peptidase, pseudogeneKidney+2.970.020
212RFPL3SRFPL3 antisenseKidney+2.960.040
213METmet proto-oncogeneKidney+2.960.013
214LAMA3laminin, alpha 3Kidney+2.950.039
215PNMA2paraneoplastic Ma antigen 2Kidney+2.950.000
216PRKD3protein kinase D3Kidney+2.940.038
217CDKN3cyclin-dependent kinase inhibitor 3Kidney+2.920.030
218LOC100505650uncharacterized LOC100505650Kidney+2.920.004
219CABYRcalcium binding tyrosine-(Y)-phosphorylation regulatedKidney+2.910.030
220TMEM169transmembrane protein 169Kidney+2.900.007
221ASPHD1aspartate beta-hydroxylase domain containing 1Kidney+2.900.002
222SATB2SATB homeobox 2Kidney+2.880.033
223CLDN1claudin 1Kidney+2.870.002
224RRP12ribosomal RNA processing 12 homolog (S. cerevisiae)Kidney+2.870.001
225FCGR2CFc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)Kidney+2.870.011
226RBAKRB-associated KRAB zinc fingerKidney+2.860.023
227NPAS2neuronal PAS domain protein 2Kidney+2.850.006
228NPTXRneuronal pentraxin receptorKidney+2.830.030
229TRMT1tRNA methyltransferase 1 homolog (S. cerevisiae)Kidney+2.820.001
230DDB2damage-specific DNA binding protein 2, 48kDaKidney+2.810.002
231NT5C5', 3'-nucleotidase, cytosolicKidney+2.810.000
232SEZ6L2seizure related 6 homolog (mouse)-like 2Kidney+2.790.019
233APBB1IPamyloid beta (A4) precursor protein-binding, family B, member 1 interacting proteinKidney+2.760.018
234CREB5cAMP responsive element binding protein 5Kidney+2.760.001
235HRH1histamine receptor H1Kidney+2.750.005
236CLEC12AC-type lectin domain family 12, member AKidney+2.750.009
237ARNTL2aryl hydrocarbon receptor nuclear translocator-like 2Kidney+2.750.012
238RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)Kidney+2.740.004
239HMHA1histocompatibility (minor) HA-1Kidney+2.740.004
240ZNF597zinc finger protein 597Kidney+2.730.000
241PLEKpleckstrinKidney+2.720.007
242HEATR6HEAT repeat containing 6Kidney+2.720.003
243C4orf47chromosome 4 open reading frame 47Kidney+2.720.030
244SNAP25synaptosomal-associated protein, 25kDaKidney+2.700.003
245CCDC103coiled-coil domain containing 103Kidney+2.690.001
246AURKAaurora kinase AKidney+2.690.011
247PGBD5piggyBac transposable element derived 5Kidney+2.690.002
248CENPKcentromere protein KKidney+2.690.030
249ISG20interferon stimulated exonuclease gene 20kDaKidney+2.670.037
250RPL22L1ribosomal protein L22-like 1Kidney+2.660.002
251FAM189A1family with sequence similarity 189, member A1Kidney+2.650.020
252BMP1bone morphogenetic protein 1Kidney+2.640.000
253ADAM28ADAM metallopeptidase domain 28Kidney+2.640.020
254CDKN2Acyclin-dependent kinase inhibitor 2AKidney+2.620.013
255HGSNATheparan-alpha-glucosaminide N-acetyltransferaseKidney+2.620.007
256IGFBP6insulin-like growth factor binding protein 6Kidney+2.600.048
257ENO2enolase 2 (gamma, neuronal)Kidney+2.600.007
258ELFN2extracellular leucine-rich repeat and fibronectin type III domain containing 2Kidney+2.590.036
259VSTM2LV-set and transmembrane domain containing 2 likeKidney+2.590.030
260G3BP1GTPase activating protein (SH3 domain) binding protein 1Kidney+2.580.002
261PTAFRplatelet-activating factor receptorKidney+2.570.001
262FAM64Afamily with sequence similarity 64, member AKidney+2.570.021
263IKBIPIKBKB interacting proteinKidney+2.570.015
264MFAP3microfibrillar-associated protein 3Kidney+2.570.022
265KDELC1KDEL (Lys-Asp-Glu-Leu) containing 1Kidney+2.570.004
266RGS1regulator of G-protein signaling 1Kidney+2.560.042
267CHPF2chondroitin polymerizing factor 2Kidney+2.550.019
268SERPINH1serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)Kidney+2.550.005
269C19orf33chromosome 19 open reading frame 33Kidney+2.550.005
270RIN3Ras and Rab interactor 3Kidney+2.530.035
271C17orf70chromosome 17 open reading frame 70Kidney+2.510.022
272SPON2spondin 2, extracellular matrix proteinKidney+2.510.014
273CAV2caveolin 2Kidney+2.490.002
274NPC1Niemann-Pick disease, type C1Kidney+2.490.005
275BHLHE41basic helix-loop-helix family, member e41Kidney+2.490.002
276KLHL29kelch-like family member 29Kidney+2.490.014
277BCHEbutyrylcholinesteraseKidney+2.480.016
278CD84CD84 moleculeKidney+2.480.038
279FDXRferredoxin reductaseKidney+2.480.001
280SYTL3synaptotagmin-like 3Kidney+2.480.001
281TRIM36tripartite motif containing 36Kidney+2.470.010
282BCAP29B-cell receptor-associated protein 29Kidney+2.460.014
283NSUN4NOP2/Sun domain family, member 4Kidney+2.460.036
284DGKAdiacylglycerol kinase, alpha 80kDaKidney+2.460.023
285MDKmidkine (neurite growth-promoting factor 2)Kidney+2.460.005
286PARVGparvin, gammaKidney+2.460.012
287CARScysteinyl-tRNA synthetaseKidney+2.460.032
288NADSYN1NAD synthetase 1Kidney+2.450.003
289LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2Kidney+2.450.025
290THOC6THO complex 6 homolog (Drosophila)Kidney+2.450.000
291AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1Kidney+2.440.042
292OTULINOTU deubiquitinase with linear linkage specificityKidney+2.440.029
293BIVMbasic, immunoglobulin-like variable motif containingKidney+2.440.043
294LOC283674uncharacterized LOC283674Kidney+2.440.024
295C5orf15chromosome 5 open reading frame 15Kidney+2.440.007
296SPHK1sphingosine kinase 1Kidney+2.430.003
297SNHG4small nucleolar RNA host gene 4 (non-protein coding)Kidney+2.420.026
298TTC9tetratricopeptide repeat domain 9Kidney+2.420.029
299GIT2G protein-coupled receptor kinase interacting ArfGAP 2Kidney+2.420.001
300CSF2RAcolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)Kidney+2.410.000
301CLEC7AC-type lectin domain family 7, member AKidney+2.400.006
302MMP7matrix metallopeptidase 7 (matrilysin, uterine)Kidney+2.400.014
303ZEB2zinc finger E-box binding homeobox 2Kidney+2.380.006
304NUDT1nudix (nucleoside diphosphate linked moiety X)-type motif 1Kidney+2.380.018
305UHRF1ubiquitin-like with PHD and ring finger domains 1Kidney+2.370.030
306PLCXD2phosphatidylinositol-specific phospholipase C, X domain containing 2Kidney+2.350.010
307RPL14ribosomal protein L14Kidney+2.340.003
308SULF2sulfatase 2Kidney+2.340.002
309NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zetaKidney+2.340.029
310H6PDhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)Kidney+2.340.033
311TYMSthymidylate synthetaseKidney+2.330.015
312NOD1nucleotide-binding oligomerization domain containing 1Kidney+2.300.000
313SMC6structural maintenance of chromosomes 6Kidney+2.300.008
314RPL13P5ribosomal protein L13 pseudogene 5Kidney+2.300.000
315SNX5sorting nexin 5Kidney+2.280.017
316ZNF474zinc finger protein 474Kidney+2.280.000
317ADAM19ADAM metallopeptidase domain 19Kidney+2.270.006
318MTFR2mitochondrial fission regulator 2Kidney+2.270.032

Expression patterns in normal tissues for genes affiliated with Papillary Renal Cell Carcinoma

Search GEO for disease gene expression data for Papillary Renal Cell Carcinoma.

Pathways for genes affiliated with Papillary Renal Cell Carcinoma

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Pathways related to Papillary Renal Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9MITF, MET
29.9FH, MET
39.6MET, MITF, FH
49.5MET, PRCC, TFE3

Compounds for genes affiliated with Papillary Renal Cell Carcinoma

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Sources:
44Novoseek, 12DrugBank, 29IUPHAR, 60Tocris Bioscience, 25HMDB
See all sources

Compounds related to Papillary Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1fumarate44 1210.9AMACR, FH
2oligonucleotide449.2AMACR, SAGE1, MET, MITF
3streptavidin449.1KRT7, AMACR
4paraffin449.0AMACR, MET, MITF, KRT7
5progesterone44 29 60 25 1212.7KRT7, MET, AMACR, SFPQ
6tyrosine448.5KRT7, FH, MITF, MET, AMACR
7glucose448.4KRT7, FH, MET, AMACR, TFE3
8testosterone44 60 25 1211.4NONO, KRT7, MET, AMACR, SFPQ

GO Terms for genes affiliated with Papillary Renal Cell Carcinoma

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Cellular components related to Papillary Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1paraspecklesGO:0423829.6NONO, SFPQ

Biological processes related to Papillary Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of osteoclast differentiationGO:0456709.8MITF, TFE3

Products for genes affiliated with Papillary Renal Cell Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Papillary Renal Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet