MCID: PPL005
MIFTS: 59

Papillary Renal Cell Carcinoma malady

Nephrological diseases, Cancer diseases, Genetic diseases categories

Summaries for Papillary Renal Cell Carcinoma

About this section
Sources:
8Disease Ontology, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 Papillary renal cell carcinoma is a renal cell carcinoma characterized as the second most common type of renal cell carcinoma. the cancerous cells form some projections in a finger shape, called papillae, in the tumor. this type of cancer is more common among african americans and has a good prognosis if treated with surgery in its early stages.

MalaCards: Papillary Renal Cell Carcinoma, also known as renal cell carcinoma, papillary, is related to papillary carcinoma and renal clear cell carcinoma. An important gene associated with Papillary Renal Cell Carcinoma is PRCC (papillary renal cell carcinoma (translocation-associated)), and among its related pathways is Pathways in cancer. The compounds paraffin and oligonucleotide have been mentioned in the context of this disorder. Affiliated tissues include kidney, thyroid and brain, and related mouse phenotype normal.

Description from OMIM:46 605074

Aliases & Classifications for Papillary Renal Cell Carcinoma

About this section
Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 26ICD10 via Orphanet, 35MESH via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases
Anatomical: Nephrological diseases


Characteristics (Orphanet epidemiological data):

48
familial papillary renal cell carcinoma:
Inheritance: Autosomal dominant; Age of onset: Adulthood


Aliases & Descriptions:

papillary renal cell carcinoma 8 42 10 48 60
renal cell carcinoma, papillary 9 46
papillary renal cell carcinoma, bilateral - 42
papillary renal cell carcinoma, familial - 42
papillary renal cell carcinoma, sporadic - 42
papillary renal cell carcinoma, multiple - 42
papillary renal cell carcinoma, familial 60
papillary renal cell carcinoma, sporadic 60
sporadic papillary renal cell carcinoma 8
familial papillary renal cell carcinoma 48
papillary renal carcinoma, malignant - 42
papillary renal cell adenocarcinoma 48
chromophil carcinoma of kidney 8


External Ids:

Disease Ontology8 DOID:4465
OMIM46 605074
NCIt39 C6975
SNOMED-CT56 4797003
ICD10 via Orphanet26 C64
MESH via Orphanet35 C538614
UMLS via Orphanet61 C2931899

Related Diseases for Papillary Renal Cell Carcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Papillary Renal Cell Carcinoma family:

Renal Cell Carcinoma, Papillary, 3 Renal Cell Carcinoma, Papillary, 1

Diseases related to Papillary Renal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1papillary carcinoma32.0MET, AMACR, KRT7
2renal clear cell carcinoma31.4KRT7, MET, CDH16, VHL, AMACR
3papillary adenoma30.9PRCC
4adenoma30.9VHL, FIGF, AMACR, KRT7, MMP11, MET
5renal oncocytoma30.8KRT7, CDH16, PRCC
6metanephric adenoma30.8KRT7
7angiomyolipoma30.7MITF
8papillary thyroid carcinoma30.6FIGF, MET, MMP11
9renal cell carcinoma, papillary, 130.4PRCC, TFE3
10adenocarcinoma30.2FIGF, MET, VHL, KRT7, MMP11, AMACR
11kidney cancer30.2MET, MAD2L2, PRCC, MITF, TFE3, VHL
12renal cell carcinoma11.4
13hereditary renal cell carcinoma10.6
14renal adenoma10.6
15familial renal papillary carcinoma10.6
16mucinous tubular and spindle renal cell carcinoma10.5
17spindle cell carcinoma10.5
18kidney disease10.5
19hereditary leiomyomatosis and renal cell cancer10.5
20renal cell carcinoma, clear cell, somatic10.5
21small cell carcinoma10.4
22gastrointestinal stromal tumor10.4
23thyroiditis10.4
24polycystic kidney disease10.3
25von hippel-lindau disease10.3
26autosomal dominant disease10.3
27cystic kidney10.3
28kidney angiomyolipoma10.3
29polycystic kidney disease, autosomal dominant10.3
30renal cell carcinoma, papillary, 1, familial and somatic10.3
31renal cell carcinoma, papillary, 310.3
32crescentic glomerulonephritis10.2
33renal wilms' tumor10.2
34parathyroid carcinoma10.2
35xanthogranulomatous pyelonephritis10.2
36collecting duct carcinoma10.2
37nonpapillary renal cell carcinoma10.2
38adenoid cystic carcinoma10.2
39large cell carcinoma10.2
40adenoiditis10.2
41b cell deficiency10.2
42cell type cancer10.2
43cervicitis10.2
44glomerulonephritis10.2
45in situ carcinoma10.2
46leiomyomatosis10.2
47lipomatosis10.2
48malignant teratoma10.2
49nephroblastoma10.2
50neuropathy10.2

Graphical network of the top 20 diseases related to Papillary Renal Cell Carcinoma:



Diseases related to papillary renal cell carcinoma

Clinical Features for Papillary Renal Cell Carcinoma

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

605074

Drugs & Therapeutics for Papillary Renal Cell Carcinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Papillary Renal Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Papillary Renal Cell Carcinoma

Search NIH Clinical Center for Papillary Renal Cell Carcinoma

Search CenterWatch for Papillary Renal Cell Carcinoma

Genetic Tests for Papillary Renal Cell Carcinoma

About this section

Anatomical Context for Papillary Renal Cell Carcinoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Papillary Renal Cell Carcinoma:

32
Kidney, Thyroid, Brain, Endothelial, Testes, Smooth muscle, B cells, Bone marrow, Lymph node, Bone, Small intestine

Animal Models for Papillary Renal Cell Carcinoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Papillary Renal Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.0NONO, CDR2, MITF, FIGF, MET, TFE3

Publications for Papillary Renal Cell Carcinoma

About this section
Sources:
50PubMed
See all sources

Articles related to Papillary Renal Cell Carcinoma:

(show top 50)    (show all 284)
idTitleAuthorsYear
1
Gene expression profiling of clear cell papillary renal cell carcinoma: comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma. (23887297)
2013
2
Prolonged survival of a patient with papillary renal cell carcinoma and brain metastases using pazopanib. (23319695)
2013
3
Prolonged efficacy of mTOR inhibitors in papillary renal cell carcinoma: progression-free survival lasting for over 3A years, a case report and review of the literature. (23283668)
2013
4
Human de novo papillary renal-cell carcinomas in a kidney graft: evidence of recipient origin with adenoma-carcinoma sequence. (23425311)
2013
5
Oncocytic papillary renal cell carcinoma: a clinicopathological study emphasizing distinct morphology, extended immunohistochemical profile and cytogenetic features. (23826421)
2013
6
Renal-cell carcinomas in end-stage kidneys: a clinicopathological study with emphasis on clear-cell papillary renal-cell carcinoma and acquired cystic kidney disease-associated carcinoma. (21791489)
2012
7
Papillary renal cell carcinoma with smooth muscle rich stroma: a case report. (22744171)
2012
8
Expression of stem-cell markers OCT-4 and CD133: important prognostic factors in papillary renal cell carcinoma. (22944295)
2012
9
Histologic tumor necrosis is an independent prognostic indicator for clear cell and papillary renal cell carcinoma. (22261455)
2012
10
Case of hereditary papillary renal cell carcinoma. (23882344)
2011
11
Novel FH mutations in families with hereditary leiomyomatosis and renal cell cancer (HLRCC) and patients with isolated type 2 papillary renal cell carcinoma. (21398687)
2011
12
Clear cell papillary renal cell carcinoma and clear cell renal cell carcinoma arising in acquired cystic disease of the kidney: an immunohistochemical and genetic study. (20952286)
2011
13
Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins. (21602815)
2011
14
De novo papillary renal cell carcinoma in an allograft kidney: evidence of donor origin. (22029684)
2011
15
Papillary renal cell carcinoma: report of a rare entity in childhood with review of the clinical management. (21683189)
2011
16
The utility of PAX-2 and renal cell carcinoma marker immunohistochemistry in distinguishing papillary renal cell carcinoma from nonrenal cell neoplasms with papillary features. (21102195)
2010
17
Development and external validation of a nomogram predicting disease specific survival after nephrectomy for papillary renal cell carcinoma. (20478577)
2010
18
Diagnostic and prognostic tissuemarkers in clear cell and papillary renal cell carcinoma. (21694464)
2010
19
A report of succinate dehydrogenase B deficiency associated with metastatic papillary renal cell carcinoma: successful treatment with the multi-targeted tyrosine kinase inhibitor sunitinib. (21686655)
2009
20
A case of oncocytic papillary renal cell carcinoma. (19769658)
2009
21
Oncocytic papillary renal cell carcinoma with inverted nuclear pattern: distinct subtype with an indolent clinical course. (19261090)
2009
22
Expression of AKR1C3 in renal cell carcinoma, papillary urothelial carcinoma, and Wilms' tumor. (20126582)
2009
23
Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implications for pathologic classification. (19898225)
2009
24
Renal cell carcinoma with extensive clear cell change sharing characteristics of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma. (19712140)
2009
25
Phase II trial of carboplatin and paclitaxel in papillary renal cell carcinoma. (19213667)
2009
26
Analysis of clinicopathologic predictors of oncologic outcome provides insight into the natural history of surgically managed papillary renal cell carcinoma. (18240184)
2008
27
Renal cell carcinomas with papillary architecture and clear cell components: the utility of immunohistochemical and cytogenetical analyses in differential diagnosis. (18779729)
2008
28
Oncocytic papillary renal cell carcinoma with solid architecture: mimic of renal oncocytoma. (18251779)
2008
29
Clear cell papillary cystadenoma of epididymis, a mimic of metastatic renal cell carcinoma. (18655434)
2008
30
Comparison of type I and II papillary renal cell carcinoma (RCC) and clear cell RCC. (18782311)
2008
31
Coexistence of papillary renal cell carcinoma and gastrointestinal stromal tumor in a case. (17450496)
2007
32
CT and MRI in fat-containing papillary renal cell carcinoma. (17928486)
2007
33
Morphological subtyping of papillary renal cell carcinoma: clinicopathological characteristics and prognosis. (17681054)
2007
34
A renal cell carcinoma with components of both chromophobe and papillary carcinoma. (17124599)
2007
35
Altered messenger RNA and protein expressions for insulin-like growth factor family members in clear cell and papillary renal cell carcinomas. (15661050)
2005
36
Expression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma. (14707866)
2004
37
Rupture of papillary renal cell carcinoma. (15841782)
2004
38
PSF-TFE3 oncoprotein in papillary renal cell carcinoma inactivates TFE3 and p53 through cytoplasmic sequestration. (12902986)
2003
39
Papillary renal cell carcinoma in a young adult: serial changes in diagnostic images. (12579262)
2003
40
Papillary renal cell carcinoma within the wall of a solitary renal cyst. (14606305)
2003
41
Genomic structure, chromosomal localization, and embryonic expression of the mouse homolog of PRCC, a gene associated with papillary renal cell carcinoma. (11435707)
2001
42
Solid variant of papillary renal cell carcinoma. (11725629)
2001
43
Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma. (11585766)
2001
44
Voided urine cytology of papillary renal cell carcinoma and renal calculus: report of a case with emphasis on the importance of cytologic screening in high-risk individuals. (11575659)
2001
45
Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. (9195569)
1997
46
Residents' teaching files. Papillary renal cell carcinoma: diagnostic dilemma of a cystic renal mass. (9225396)
1997
47
Mutation of the VHL gene is associated exclusively with the development of non-papillary renal cell carcinomas. (8758207)
1996
48
Identification of a yeast artificial chromosome that spans the human papillary renal cell carcinoma-associated t(X;1) breakpoint in Xp11.2. (8281521)
1993
49
Retroperitoneal fibrosis as host response to papillary renal cell carcinoma. (1887541)
1991
50
Papillary renal cell carcinoma: CT and sonographic evaluation. (6385668)
1984

Genetic Variations for Papillary Renal Cell Carcinoma

About this section
Sources:
62UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Papillary Renal Cell Carcinoma:

62 (show all 15)
id Symbol AA change Variation ID SNP ID
1METp.Met1131ThrVAR_006286
2METp.Val1188LeuVAR_006287
3METp.Leu1195ValVAR_006288
4METp.Val1220IleVAR_006289
5METp.Asp1228AsnVAR_006290
6METp.Asp1228HisVAR_006291
7METp.Tyr1230CysVAR_006292
8METp.Tyr1230HisVAR_006293
9METp.Met1250ThrVAR_006294
10METp.Val1092IleVAR_032485
11METp.His1094LeuVAR_032486
12METp.His1094ArgVAR_032487
13METp.His1094TyrVAR_032488
14METp.His1106AspVAR_032489
15METp.Tyr1230AspVAR_032491

Expression for genes affiliated with Papillary Renal Cell Carcinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Papillary Renal Cell Carcinoma

Search GEO for disease gene expression data for Papillary Renal Cell Carcinoma.

Pathways for genes affiliated with Papillary Renal Cell Carcinoma

About this section
Sources:
29KEGG
See all sources

Pathways related to Papillary Renal Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2MITF, FIGF, MET, VHL

Compounds for genes affiliated with Papillary Renal Cell Carcinoma

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Papillary Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1paraffin4410.2MMP11, KRT7, MET, AMACR, MITF
2oligonucleotide4410.1AMACR, MMP11, MITF, MET, SAGE1, VHL
3testosterone44 59 11 2413.1NONO, KRT7, MET, SFPQ, AMACR
4progesterone44 59 28 11 2414.1MET, AMACR, SFPQ, IGFBP6, FIGF, MMP11
5vegf4410.1VHL, MET, FIGF, MMP11, KRT7
6fumarate44 1111.1AMACR, VHL
7tyrosine449.9VHL, AMACR, MET, IGFBP6, FIGF, MITF

GO Terms for genes affiliated with Papillary Renal Cell Carcinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Papillary Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1paraspecklesGO:04238210.3NONO, SFPQ

Biological processes related to Papillary Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of osteoclast differentiationGO:04567010.3MITF, TFE3

Molecular functions related to Papillary Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.6NONO, SFPQ, MET, AKR1B10, PRCC, TBC1D25

Products for genes affiliated with Papillary Renal Cell Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Papillary Renal Cell Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet