MCID: PPL007
MIFTS: 38

Papillary Serous Adenocarcinoma malady

Cancer diseases category

Summaries for Papillary Serous Adenocarcinoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A papillary adenocarcinoma that derives from epithelial cells originating in glandular tissue, which form complex papillary structures with psammoma bodies.

MalaCards: Papillary Serous Adenocarcinoma, also known as serous surface papillary carcinoma, is related to papillary adenocarcinoma and cystadenocarcinoma. An important gene associated with Papillary Serous Adenocarcinoma is NKX2-1 (NK2 homeobox 1). The compounds megestrol acetate and anastrozole have been mentioned in the context of this disorder. Affiliated tissues include ovary, cervix and breast.

Aliases & Classifications for Papillary Serous Adenocarcinoma

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

papillary serous adenocarcinoma 8
serous surface papillary carcinoma 8 60
papillary serous cystadenocarcinoma 60
micropapillary serous carcinoma 8
papillary serous carcinoma 8


External Ids:

Disease Ontology8 DOID:2632
SNOMED-CT56 15674004, 90282004
NCIt39 C6882, C8377

Related Diseases for Papillary Serous Adenocarcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Papillary Serous Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1papillary adenocarcinoma31.3NKX2-1, MUC16
2cystadenocarcinoma31.3MUC16
3adenocarcinoma31.3ERBB2, KRT20, KRT7, PGR, MUC16, NKX2-1
4ovarian serous cystadenocarcinoma30.9MUC16
5papillary carcinoma30.8KRT7, NKX2-1, PGR, KRT20, ERBB2, MUC16
6peritonitis30.6MUC16
7endometrial carcinoma30.5MUC16, ERBB2, PGR
8breast cancer30.4ERBB2, PGR, KRT7, MUC16
9bilateral breast cancer30.2PGR
10gastric adenocarcinoma30.2ERBB2, KRT20, MUC16, KRT7
11ovarian cancer30.2KRT7, MUC16, PGR, ERBB2
12leiomyoma30.2PGR
13adenofibroma30.2MUC16
14uterine carcinosarcoma30.2ERBB2
15angiomyolipoma30.2PGR
16endometriosis30.2MUC16, PGR
17neuroendocrine carcinoma30.2NKX2-1, KRT7, KRT20
18large cell carcinoma30.2KRT20, KRT7, ERBB2, NKX2-1
19serous cystadenocarcinoma10.9
20papillary cystadenocarcinoma10.9
21ovarian cystadenocarcinoma10.6
22ovary adenocarcinoma10.5
23ovary serous adenocarcinoma10.5
24ovary papillary carcinoma10.5
25primary peritoneal carcinoma10.5
26peritoneal serous papillary adenocarcinoma10.4
27peritoneal serous adenocarcinoma10.4
28breast adenocarcinoma10.3
29endosalpingiosis10.2
30cystic teratoma10.2
31hereditary breast ovarian cancer10.2
32gastric papillary adenocarcinoma10.2
33fallopian tube serous adenocarcinoma10.2
34fallopian tube papillary adenocarcinoma10.2
35cerebellar disease10.2
36fallopian tube adenocarcinoma10.2
37panniculitis10.2
38vaginitis10.2
39endocervical carcinoma10.1
40ovarian endometriosis10.1
41tuberous sclerosis10.1
42lymphangioleiomyomatosis10.1
43endocervicitis10.1
44thrombocytosis10.1
45tuberculous peritonitis10.1
46papillary adenofibroma10.1
47multicentric reticulohistiocytosis10.1
48in situ carcinoma10.1
49malignant adenofibroma10.1
50pulmonary fibrosis10.1

Graphical network of the top 20 diseases related to Papillary Serous Adenocarcinoma:



Diseases related to papillary serous adenocarcinoma

Clinical Features for Papillary Serous Adenocarcinoma

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Drugs & Therapeutics for Papillary Serous Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Papillary Serous Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Papillary Serous Adenocarcinoma

Search NIH Clinical Center for Papillary Serous Adenocarcinoma

Search CenterWatch for Papillary Serous Adenocarcinoma

Genetic Tests for Papillary Serous Adenocarcinoma

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Anatomical Context for Papillary Serous Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Papillary Serous Adenocarcinoma:

32
Ovary, Cervix, Breast, Lymph node, Testis, Brain, Uterus, Appendix

Animal Models for Papillary Serous Adenocarcinoma or affiliated genes

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Publications for Papillary Serous Adenocarcinoma

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50PubMed
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Articles related to Papillary Serous Adenocarcinoma:

(show top 50)    (show all 60)
idTitleAuthorsYear
1
Metachronous pancreatic metastasis of an ovarian serous papillary adenocarcinoma after 8 years. (24294516)
2013
2
Multiple brain metastases in a patient with uterine papillary serous adenocarcinoma: Treatment options for this rarely seen metastatic brain tumor. (24032086)
2013
3
Laparoscopic diagnosis of adenocarcinoma of the appendix mimicking serous papillary adenocarcinoma of the peritoneum. (24383020)
2013
4
Overexpression of annexin A4 is associated with chemoresistance in papillary serous adenocarcinoma of the ovary. (23290009)
2013
5
Pathological implication and function of Bcl2-inhibitor of transcription in ovarian serous papillary adenocarcinomas. (23259782)
2013
6
Salivary transcriptomic biomarkers for detection of ovarian cancer: for serous papillary adenocarcinoma. (22095100)
2012
7
Malignant mixed mullerian tumor of endometrium coexisting with bilateral papillary serous adenocarcinoma of fallopian tube: a rare case report. (24293882)
2012
8
F-18 fluoride uptake in calcified extraosseous metastases from ovarian papillary serous adenocarcinoma. (22157054)
2012
9
Serous papillary adenocarcinoma probably arising from epithelial inclusions of the hepatic hilar lymph node. (22392484)
2012
10
Immunohistochemical profile of paratesticular serous papillary adenocarcinoma and tunica vaginalis facilitates distinction from malignant mesothelioma. (19493919)
2011
11
Papillary serous adenocarcinoma of the uterine cervix: a case report. (21614930)
2011
12
A case of bilateral ovarian synchronous tumors (left ovarian serous papillary adenocarcinoma and right ovarian malignant mixed MA1llerian tumor). (21614928)
2011
13
Serous papillary adenocarcinoma possibly related to the presence of primitive oocyte-like cells in the adult ovarian surface epithelium: a case report. (21827672)
2011
14
In vitro activity of pertuzumab in combination with trastuzumab in uterine serous papillary adenocarcinoma. (19920829)
2010
15
Acute gastric outlet obstruction secondary to papillary serous adenocarcinoma of the endometrium with peritoneal psammomatous implants: a case report. (19132421)
2010
16
Successful Treatment of Primary Vaginal Papillary Serous Adenocarcinoma Using Chemoradiation Followed by Brachytherapy. (20740170)
2009
17
99mTc-MDP and 18F-FDG uptake in calcified metastatic lesions from ovarian papillary serous adenocarcinoma. (19936349)
2009
18
Serous papillary adenocarcinoma of the female genital organs and invasive micropapillary carcinoma of the breast. Are WT1, CA125, and GCDFP-15 useful in differential diagnosis? (18339419)
2008
19
Unknown primary site of serous papillary adenocarcinoma involving inguinal, iliac and obturator lymph nodes co-existing with endometrial adenocarcinoma. (17701821)
2007
20
Malignant pericardial tamponade secondary to papillary serous adenocarcinoma of the ovary. (17491236)
2007
21
Serous papillary adenocarcinoma of the rete testis: unusual ultrasonography and pathological findings. (17998718)
2007
22
A long-term survivor of repeated inguinal nodes recurrence of papillary serous adenocarcinoma of CUP: case report. (16930493)
2006
23
Canine ovarian serous papillary adenocarcinoma with neoplastic hypercalcemia. (17019069)
2006
24
Pulmonary papillary serous adenocarcinoma with intraperitoneal and ovarian tumors: identification of primary site. A case report. (16515596)
2006
25
Serous papillary adenocarcinoma and adult granulosa cell tumor in the same ovary. An unusual case. (16309432)
2005
26
Papillary serous adenocarcinoma of the endometrium: CT-pathologic correlation. (15150003)
2004
27
Establishment and characterization of two cell lines (HEC-155, HEC-180) derived from uterine papillary serous adenocarcinoma. (15285295)
2004
28
Cytogenetic abnormalities in serous papillary adenocarcinoma of the ovary. (15493170)
2004
29
Papillary serous adenocarcinoma of the ovary diagnosed after malignant pericardial tamponade and embolic stroke. (11855887)
2002
30
Accumulation of Tc-99m HMDP in ovarian serous papillary adenocarcinoma reflecting ongoing calcification. (11564940)
2001
31
Cerebellar metastasis from papillary serous adenocarcinoma of the ovary mimicking MAcniA"re's disease. A case report. (11304872)
2001
32
Papillary serous adenocarcinoma of the endocervix: A rare neoplasm. Immunohistochemical profile. (11240696)
2000
33
Is uterine papillary serous adenocarcinoma a manifestation of the hereditary breast-ovarian cancer syndrome? (11104623)
2000
34
Tumor angiogenesis and thymidine phosphorylase expression in ovarian carcinomas including serous surface papillary adenocarcinoma of the peritoneum. (11109165)
2000
35
Establishment and characterization of a serous papillary adenocarcinoma cell line of the human ovary in a serum-free culture. (10337661)
1999
36
The combination paclitaxel, carboplatin and megestrol acetate is effective in women with recurrent uterine papillary serous adenocarcinoma. (10422674)
1999
37
Cytologic features of papillary serous adenocarcinoma of the uterine cervix. (9126137)
1997
38
Histologic characterization of uterine papillary serous adenocarcinoma. (7705679)
1995
39
Pregnancy coexisting with serous papillary adenocarcinoma involving both uterus and ovary. (8206413)
1994
40
Expression of EGFR, HER-2/neu, P53, and PCNA in endometrioid, serous papillary, and clear cell endometrial adenocarcinomas. (7909788)
1994
41
Uterine papillary serous adenocarcinoma. A 10-case study of p53 and c-erbB-2 expression and DNA content. (7915964)
1994
42
Serous papillary adenocarcinoma of the endometrium. A unique entity with a grave prognosis. Case report and review of the literature. (8472732)
1993
43
Serous papillary adenocarcinoma of the uterine cervix. (8344663)
1993
44
Papillary serous adenocarcinoma of the endometrium: a clinicopathologic study of 19 cases. (1634141)
1992
45
Primary peritoneal papillary serous adenocarcinoma: clinical and management aspects. (2013445)
1991
46
Two cases of peritoneal serous papillary adenocarcinoma. (1721482)
1991
47
Serous papillary adenocarcinoma of the endometrium. Analysis of proto-oncogene amplification, flow cytometry, estrogen and progesterone receptors, and immunohistochemistry. (1690076)
1990
48
Peritoneal malignant mesothelioma versus serous papillary adenocarcinoma. A histochemical and immunohistochemical comparison. (2473660)
1989
49
Papillary serous adenocarcinoma of the endometrium. (3960439)
1986
50
Papillary serous adenocarcinoma. (18870241)
1948

Genetic Variations for Papillary Serous Adenocarcinoma

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Expression for genes affiliated with Papillary Serous Adenocarcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papillary Serous Adenocarcinoma

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Pathways for genes affiliated with Papillary Serous Adenocarcinoma

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Compounds for genes affiliated with Papillary Serous Adenocarcinoma

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44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Papillary Serous Adenocarcinoma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1megestrol acetate4410.0ERBB2, PGR
2anastrozole44 1110.9ERBB2, PGR
3capecitabine44 49 1111.9ERBB2, PGR
4exemestane49 44 59 1112.9ERBB2, PGR
5lapatinib44 49 1111.9ERBB2, PGR
6toremifene44 1110.9ERBB2, PGR
7fulvestrant44 49 28 1112.9PGR, ERBB2
8taxane449.8ERBB2, PGR
9letrozole44 49 59 1112.8ERBB2, PGR
10leucovorin44 49 1111.6ERBB2, PGR
11trastuzumab44 49 1111.6ERBB2, PGR
12dexamethasone44 49 28 1112.6NKX2-1, MUC16
13raloxifene44 28 49 1112.5PGR, ERBB2
14gnrh449.5NKX2-1, PGR, ERBB2
15streptavidin449.5KRT20, KRT7
16ribonucleic acid449.3NKX2-1, PGR, KRT20
17mucicarmine449.3KRT20, KRT7, NKX2-1
18methotrexate44 49 1111.3ERBB2, KRT7, PGR
19topotecan44 1110.3ERBB2, MUC16
20cyclophosphamide44 49 1111.1MUC16, PGR, ERBB2
21paclitaxel44 49 1110.9MUC16, PGR, ERBB2
22formaldehyde44 249.9NKX2-1, KRT7, KRT20, ERBB2
23steroid448.7NKX2-1, MUC16, PGR, ERBB2
24doxorubicin44 49 1110.6ERBB2, KRT20, PGR, MUC16
25b 723448.5NKX2-1, MUC16, KRT7, KRT20
26hematoxylin448.5NKX2-1, MUC16, KRT7, KRT20
27iron44 249.2KRT20, KRT7, MUC16
28testosterone44 59 11 2411.0ERBB2, KRT20, KRT7, PGR, MUC16
29vegf448.0MUC16, PGR, KRT7, KRT20, ERBB2
30paraffin447.7ERBB2, KRT20, KRT7, PGR, MUC16, NKX2-1
31progesterone44 59 28 11 2411.7NKX2-1, MUC16, PGR, KRT7, KRT20, ERBB2
32tyrosine447.5NKX2-1, ANXA4, MUC16, KRT7, KRT20, ERBB2

GO Terms for genes affiliated with Papillary Serous Adenocarcinoma

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Products for genes affiliated with Papillary Serous Adenocarcinoma

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Sources for Papillary Serous Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet