MCID: PPL007
MIFTS: 36

Papillary Serous Adenocarcinoma malady

Cancer category

Summaries for Papillary Serous Adenocarcinoma

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A papillary adenocarcinoma that derives from epithelial cells originating in glandular tissue, which form complex papillary structures with psammoma bodies.

MalaCards: Papillary Serous Adenocarcinoma, also known as serous surface papillary carcinoma, is related to adenocarcinoma and ovarian serous cystadenocarcinoma. An important gene associated with Papillary Serous Adenocarcinoma is NKX2-1 (NK2 homeobox 1). The compounds megestrol acetate and anastrozole have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and breast.

Aliases & Classifications for Papillary Serous Adenocarcinoma

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 57SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

papillary serous adenocarcinoma 8
serous surface papillary carcinoma 8 61
papillary serous cystadenocarcinoma 61
micropapillary serous carcinoma 8
papillary serous carcinoma 8


External Ids:

Disease Ontology8 DOID:2632
SNOMED-CT57 15674004, 90282004
NCIt40 C6882, C8377

Related Diseases for Papillary Serous Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Papillary Serous Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.4ERBB2, KRT20, KRT7, PGR, MUC16, NKX2-1
2ovarian serous cystadenocarcinoma31.0MUC16
3papillary carcinoma30.8KRT7, NKX2-1, PGR, KRT20, ERBB2, MUC16
4teratoma30.4NKX2-1, KRT7
5bilateral breast cancer30.3PGR
6malignant mixed mullerian tumor30.3KRT7, PGR, ERBB2
7adenofibroma30.2MUC16
8uterine carcinosarcoma30.2ERBB2
9angiomyolipoma30.2PGR
10neuroendocrine carcinoma30.2NKX2-1, KRT7, KRT20
11large cell carcinoma30.2KRT20, KRT7, ERBB2, NKX2-1
12serous cystadenocarcinoma11.0
13papillary cystadenocarcinoma11.0
14ovary papillary carcinoma10.5
15primary peritoneal carcinoma10.5
16peritoneal carcinoma10.5
17peritoneal serous papillary adenocarcinoma10.4
18breast adenocarcinoma10.4
19endosalpingiosis10.3
20malignant ovarian cyst10.3
21hereditary breast ovarian cancer10.2
22gastric papillary adenocarcinoma10.2
23fallopian tube serous adenocarcinoma10.2
24fallopian tube papillary adenocarcinoma10.2
25gastric outlet obstruction10.2
26endocervical carcinoma10.2
27ovarian endometriosis10.2
28tuberous sclerosis10.2
29lymphangioleiomyomatosis10.2
30thrombocytosis10.2
31tuberculous peritonitis10.2
32papillary adenofibroma10.2
33multicentric reticulohistiocytosis10.2
34uterine disease10.2
35tuberous sclerosis complex10.2
36adenomyosis10.2
37cerebellar degeneration10.2
38paraneoplastic cerebellar degeneration10.2
39colon adenocarcinoma10.0KRT20
40papilloma10.0KRT20
41cystadenoma10.0KRT7
42mixed cell type cancer10.0KRT7
43hemangioma10.0NKX2-1
44renal clear cell carcinoma10.0KRT7
45chordoma10.0KRT7
46leiomyoma10.0PGR
47secretory meningioma10.0KRT7
48fibromatosis10.0PGR
49cystadenocarcinoma10.0MUC16
50inverted papilloma10.0KRT20

Graphical network of the top 20 diseases related to Papillary Serous Adenocarcinoma:



Diseases related to papillary serous adenocarcinoma

Clinical Features for Papillary Serous Adenocarcinoma

Drugs & Therapeutics for Papillary Serous Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Papillary Serous Adenocarcinoma

Drug clinical trials:

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Search NIH Clinical Center for Papillary Serous Adenocarcinoma

Search CenterWatch for Papillary Serous Adenocarcinoma

Genetic Tests for Papillary Serous Adenocarcinoma

Anatomical Context for Papillary Serous Adenocarcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Papillary Serous Adenocarcinoma:

33
Lymph node, Brain, Breast, Ovary, Uterus, Testis, Cervix, Appendix

Animal Models for Papillary Serous Adenocarcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Papillary Serous Adenocarcinoma

Sources:
51PubMed
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Articles related to Papillary Serous Adenocarcinoma:

(show top 50)    (show all 60)
idTitleAuthorsYear
1
Metachronous pancreatic metastasis of an ovarian serous papillary adenocarcinoma after 8 years. (24294516)
2013
2
Multiple brain metastases in a patient with uterine papillary serous adenocarcinoma: Treatment options for this rarely seen metastatic brain tumor. (24032086)
2013
3
Laparoscopic diagnosis of adenocarcinoma of the appendix mimicking serous papillary adenocarcinoma of the peritoneum. (24383020)
2013
4
Overexpression of annexin A4 is associated with chemoresistance in papillary serous adenocarcinoma of the ovary. (23290009)
2013
5
Pathological implication and function of Bcl2-inhibitor of transcription in ovarian serous papillary adenocarcinomas. (23259782)
2013
6
Salivary transcriptomic biomarkers for detection of ovarian cancer: for serous papillary adenocarcinoma. (22095100)
2012
7
Malignant mixed mullerian tumor of endometrium coexisting with bilateral papillary serous adenocarcinoma of fallopian tube: a rare case report. (24293882)
2012
8
F-18 fluoride uptake in calcified extraosseous metastases from ovarian papillary serous adenocarcinoma. (22157054)
2012
9
Papillary-serous adenocarcinoma of the uterine cervix during tamoxifen therapy after bilateral breast cancer. (23155282)
2012
10
Immunohistochemical profile of paratesticular serous papillary adenocarcinoma and tunica vaginalis facilitates distinction from malignant mesothelioma. (19493919)
2011
11
Papillary serous adenocarcinoma of the uterine cervix: a case report. (21614930)
2011
12
A case of bilateral ovarian synchronous tumors (left ovarian serous papillary adenocarcinoma and right ovarian malignant mixed MA1llerian tumor). (21614928)
2011
13
Serous papillary adenocarcinoma possibly related to the presence of primitive oocyte-like cells in the adult ovarian surface epithelium: a case report. (21827672)
2011
14
In vitro activity of pertuzumab in combination with trastuzumab in uterine serous papillary adenocarcinoma. (19920829)
2010
15
Acute gastric outlet obstruction secondary to papillary serous adenocarcinoma of the endometrium with peritoneal psammomatous implants: a case report. (19132421)
2010
16
Successful Treatment of Primary Vaginal Papillary Serous Adenocarcinoma Using Chemoradiation Followed by Brachytherapy. (20740170)
2009
17
Serous papillary adenocarcinoma of the female genital organs and invasive micropapillary carcinoma of the breast. Are WT1, CA125, and GCDFP-15 useful in differential diagnosis? (18339419)
2008
18
Malignant pericardial tamponade secondary to papillary serous adenocarcinoma of the ovary. (17491236)
2007
19
A long-term survivor of repeated inguinal nodes recurrence of papillary serous adenocarcinoma of CUP: case report. (16930493)
2006
20
Claudin 1 differentiates endometrioid and serous papillary endometrial adenocarcinoma. (16797678)
2006
21
Pulmonary papillary serous adenocarcinoma with intraperitoneal and ovarian tumors: identification of primary site. A case report. (16515596)
2006
22
Peritoneal serous papillary adenocarcinoma: report of four cases. (16258208)
2005
23
Serous papillary adenocarcinoma and adult granulosa cell tumor in the same ovary. An unusual case. (16309432)
2005
24
Weekly topotecan in a heavily pretreated patient with peritoneal papillary serous adenocarcinoma. (15228430)
2004
25
Papillary serous adenocarcinoma of the endometrium: CT-pathologic correlation. (15150003)
2004
26
Establishment and characterization of two cell lines (HEC-155, HEC-180) derived from uterine papillary serous adenocarcinoma. (15285295)
2004
27
Papillary serous adenocarcinoma of the ovary diagnosed after malignant pericardial tamponade and embolic stroke. (11855887)
2002
28
Accumulation of Tc-99m HMDP in ovarian serous papillary adenocarcinoma reflecting ongoing calcification. (11564940)
2001
29
Cerebellar metastasis from papillary serous adenocarcinoma of the ovary mimicking MAcniA"re's disease. A case report. (11304872)
2001
30
Papillary serous adenocarcinoma of the endocervix: A rare neoplasm. Immunohistochemical profile. (11240696)
2000
31
Is uterine papillary serous adenocarcinoma a manifestation of the hereditary breast-ovarian cancer syndrome? (11104623)
2000
32
Tumor angiogenesis and thymidine phosphorylase expression in ovarian carcinomas including serous surface papillary adenocarcinoma of the peritoneum. (11109165)
2000
33
Establishment and characterization of a serous papillary adenocarcinoma cell line of the human ovary in a serum-free culture. (10337661)
1999
34
The combination paclitaxel, carboplatin and megestrol acetate is effective in women with recurrent uterine papillary serous adenocarcinoma. (10422674)
1999
35
Multiple nodular metastases in mesenteric panniculitis by uterine papillary serous adenocarcinoma (UPSC): CT appearance of a case. (10416083)
1999
36
Supradiaphragmatic manifestations of papillary serous adenocarcinoma of the ovary. (10580766)
1999
37
Primary serous papillary adenocarcinoma of the vagina: a case report. (9421097)
1997
38
Cytologic features of papillary serous adenocarcinoma of the uterine cervix. (9126137)
1997
39
Histologic characterization of uterine papillary serous adenocarcinoma. (7705679)
1995
40
Pregnancy coexisting with serous papillary adenocarcinoma involving both uterus and ovary. (8206413)
1994
41
Expression of EGFR, HER-2/neu, P53, and PCNA in endometrioid, serous papillary, and clear cell endometrial adenocarcinomas. (7909788)
1994
42
Uterine papillary serous adenocarcinoma. A 10-case study of p53 and c-erbB-2 expression and DNA content. (7915964)
1994
43
Papillary serous adenocarcinoma of the uterine cervix: a report of three cases. (1495949)
1992
44
Papillary serous adenocarcinoma of the endometrium: a clinicopathologic study of 19 cases. (1634141)
1992
45
Serous papillary adenocarcinoma of the tunica vaginalis of the testis with metastasis. (1991312)
1991
46
Primary peritoneal papillary serous adenocarcinoma: clinical and management aspects. (2013445)
1991
47
Two cases of peritoneal serous papillary adenocarcinoma. (1721482)
1991
48
Invasive papillary serous adenocarcinoma of the endocervix in pregnancy; a case report. (1855609)
1991
49
Peritoneal malignant mesothelioma versus serous papillary adenocarcinoma. A histochemical and immunohistochemical comparison. (2473660)
1989
50
Papillary serous adenocarcinoma of the endometrium. (3960439)
1986

Genetic Variations for Papillary Serous Adenocarcinoma

Expression for genes affiliated with Papillary Serous Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papillary Serous Adenocarcinoma

Search GEO for disease gene expression data for Papillary Serous Adenocarcinoma.

Pathways for genes affiliated with Papillary Serous Adenocarcinoma

Compounds for genes affiliated with Papillary Serous Adenocarcinoma

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Papillary Serous Adenocarcinoma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1megestrol acetate4510.0ERBB2, PGR
2anastrozole45 1110.9ERBB2, PGR
3capecitabine45 50 1111.9ERBB2, PGR
4exemestane50 45 60 1112.9ERBB2, PGR
5lapatinib45 50 1111.9ERBB2, PGR
6toremifene45 1110.9ERBB2, PGR
7fulvestrant45 50 29 1112.9PGR, ERBB2
8taxane459.8ERBB2, PGR
9letrozole45 50 60 1112.8ERBB2, PGR
10leucovorin45 50 1111.6ERBB2, PGR
11trastuzumab45 50 1111.6ERBB2, PGR
12dexamethasone45 50 29 1112.6NKX2-1, MUC16
13raloxifene45 29 50 1112.5PGR, ERBB2
14gnrh459.5NKX2-1, PGR, ERBB2
15streptavidin459.5KRT20, KRT7
16ribonucleic acid459.3NKX2-1, PGR, KRT20
17mucicarmine459.3KRT20, KRT7, NKX2-1
18methotrexate45 50 1111.3ERBB2, KRT7, PGR
19topotecan45 1110.3ERBB2, MUC16
20cyclophosphamide45 50 1111.1MUC16, PGR, ERBB2
21paclitaxel45 50 1110.9MUC16, PGR, ERBB2
22formaldehyde45 249.9NKX2-1, KRT7, KRT20, ERBB2
23steroid458.7NKX2-1, MUC16, PGR, ERBB2
24doxorubicin45 50 1110.6ERBB2, KRT20, PGR, MUC16
25b 723458.5NKX2-1, MUC16, KRT7, KRT20
26hematoxylin458.5NKX2-1, MUC16, KRT7, KRT20
27iron45 249.2KRT20, KRT7, MUC16
28testosterone45 60 11 2411.0ERBB2, KRT20, KRT7, PGR, MUC16
29vegf458.0MUC16, PGR, KRT7, KRT20, ERBB2
30paraffin457.7ERBB2, KRT20, KRT7, PGR, MUC16, NKX2-1
31progesterone45 60 29 11 2411.7NKX2-1, MUC16, PGR, KRT7, KRT20, ERBB2
32tyrosine457.5NKX2-1, ANXA4, MUC16, KRT7, KRT20, ERBB2

GO Terms for genes affiliated with Papillary Serous Adenocarcinoma

Products for genes affiliated with Papillary Serous Adenocarcinoma

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Sources for Papillary Serous Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet