MCID: PPL007
MIFTS: 40

Papillary Serous Adenocarcinoma malady

Cancer diseases category
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Summaries for Papillary Serous Adenocarcinoma

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Disease Ontology:8 A papillary adenocarcinoma that derives from epithelial cells originating in glandular tissue, which form complex papillary structures with psammoma bodies.

MalaCards based summary: Papillary Serous Adenocarcinoma, also known as serous surface papillary carcinoma, is related to adenofibroma and neuroendocrine carcinoma. An important gene associated with Papillary Serous Adenocarcinoma is NKX2-1 (NK2 homeobox 1). The compounds topotecan and megestrol acetate have been mentioned in the context of this disorder. Affiliated tissues include ovary, cervix and breast.

Aliases & Classifications for Papillary Serous Adenocarcinoma

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Papillary Serous Adenocarcinoma, Aliases & Descriptions:

Name: Papillary Serous Adenocarcinoma 8
Serous Surface Papillary Carcinoma 8 62
Papillary Serous Cystadenocarcinoma 62
 
Micropapillary Serous Carcinoma 8
Papillary Serous Carcinoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:2632
SNOMED-CT57 15674004, 90282004
NCIt39 C8377, C6882

Related Diseases for Papillary Serous Adenocarcinoma

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Diseases related to Papillary Serous Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1adenofibroma30.9MUC16
2neuroendocrine carcinoma30.4KRT20, KRT7, NKX2-1
3endometrial carcinoma30.2ERBB2, MUC16, PGR
4malignant mixed mullerian tumor30.1PGR, ERBB2, KRT7
5adenocarcinoma30.1PGR, MUC16, ANXA4, NKX2-1, ERBB2, KRT7
6papillary carcinoma29.8PGR, MUC16, NKX2-1, ERBB2, KRT7, KRT20
7ovarian cancer29.7KRT7, ERBB2, MUC16, PGR
8breast cancer29.5KRT7, ERBB2, MUC16, PGR
9primary peritoneal carcinoma10.6
10peritonitis10.5
11ovary papillary carcinoma10.5
12secretory meningioma10.4KRT7
13cystadenoma10.4KRT7
14bronchogenic cyst10.4MUC16
15cystadenocarcinoma10.4MUC16
16ovarian serous cystadenocarcinoma10.4MUC16
17merkel cell carcinoma10.3NKX2-1, KRT20
18thymus cancer10.3NKX2-1, KRT7
19bladder adenocarcinoma10.2KRT20, KRT7
20ovarian brenner tumor10.2KRT7, KRT20
21signet ring cell adenocarcinoma10.2KRT7, KRT20
22hereditary breast ovarian cancer10.2
23bilateral breast cancer10.2
24panniculitis10.2
25vaginitis10.2
26gastric outlet obstruction10.2
27struma ovarii10.2MUC16, NKX2-1
28pancreatic ductal carcinoma10.2KRT7, KRT20
29papillary adenocarcinoma10.2MUC16, NKX2-1
30follicular adenoma10.2NKX2-1, KRT20
31pseudomyxoma peritonei10.2KRT7, KRT20
32teratoma10.2NKX2-1, KRT7
33pulmonary fibrosis10.2
34thrombocytosis10.2
35endometrial stromal nodule10.2
36tuberous sclerosis10.2
37uterine corpus serous adenocarcinoma10.2
38endocervicitis10.2
39ovarian serous carcinoma10.2
40large cell neuroendocrine carcinoma10.2
41tuberculous peritonitis10.2
42multicentric reticulohistiocytosis10.2
43lymphangioleiomyomatosis10.2
44angiomyolipoma10.2
45endometriosis10.2
46leiomyoma10.2
47uterine disease10.2
48tuberous sclerosis complex10.2
49adenomyosis10.2
50cerebellar degeneration10.2

Graphical network of the top 20 diseases related to Papillary Serous Adenocarcinoma:



Diseases related to papillary serous adenocarcinoma

Symptoms for Papillary Serous Adenocarcinoma

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Drugs & Therapeutics for Papillary Serous Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Papillary Serous Adenocarcinoma

Search NIH Clinical Center for Papillary Serous Adenocarcinoma

Genetic Tests for Papillary Serous Adenocarcinoma

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Anatomical Context for Papillary Serous Adenocarcinoma

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MalaCards organs/tissues related to Papillary Serous Adenocarcinoma:

32
Ovary, Cervix, Breast, Brain

Animal Models for Papillary Serous Adenocarcinoma or affiliated genes

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Publications for Papillary Serous Adenocarcinoma

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Articles related to Papillary Serous Adenocarcinoma:

(show all 30)
idTitleAuthorsYear
1
Multiple brain metastases in a patient with uterine papillary serous adenocarcinoma: Treatment options for this rarely seen metastatic brain tumor. (24032086)
2013
2
Overexpression of annexin A4 is associated with chemoresistance in papillary serous adenocarcinoma of the ovary. (23290009)
2013
3
Malignant mixed mullerian tumor of endometrium coexisting with bilateral papillary serous adenocarcinoma of fallopian tube: a rare case report. (24293882)
2012
4
F-18 fluoride uptake in calcified extraosseous metastases from ovarian papillary serous adenocarcinoma. (22157054)
2012
5
Papillary-serous adenocarcinoma of the uterine cervix during tamoxifen therapy after bilateral breast cancer. (23155282)
2012
6
Papillary serous adenocarcinoma of the uterine cervix: a case report. (21614930)
2011
7
Acute gastric outlet obstruction secondary to papillary serous adenocarcinoma of the endometrium with peritoneal psammomatous implants: a case report. (19132421)
2010
8
Successful Treatment of Primary Vaginal Papillary Serous Adenocarcinoma Using Chemoradiation Followed by Brachytherapy. (20740170)
2009
9
99mTc-MDP and 18F-FDG uptake in calcified metastatic lesions from ovarian papillary serous adenocarcinoma. (19936349)
2009
10
Malignant pericardial tamponade secondary to papillary serous adenocarcinoma of the ovary. (17491236)
2007
11
A long-term survivor of repeated inguinal nodes recurrence of papillary serous adenocarcinoma of CUP: case report. (16930493)
2006
12
Pulmonary papillary serous adenocarcinoma with intraperitoneal and ovarian tumors: identification of primary site. A case report. (16515596)
2006
13
Weekly topotecan in a heavily pretreated patient with peritoneal papillary serous adenocarcinoma. (15228430)
2004
14
Establishment and characterization of two cell lines (HEC-155, HEC-180) derived from uterine papillary serous adenocarcinoma. (15285295)
2004
15
Papillary serous adenocarcinoma of the ovary diagnosed after malignant pericardial tamponade and embolic stroke. (11855887)
2002
16
Cerebellar metastasis from papillary serous adenocarcinoma of the ovary mimicking MAcniA"re's disease. A case report. (11304872)
2001
17
Papillary serous adenocarcinoma of the endocervix: A rare neoplasm. Immunohistochemical profile. (11240696)
2000
18
Is uterine papillary serous adenocarcinoma a manifestation of the hereditary breast-ovarian cancer syndrome? (11104623)
2000
19
The combination paclitaxel, carboplatin and megestrol acetate is effective in women with recurrent uterine papillary serous adenocarcinoma. (10422674)
1999
20
Multiple nodular metastases in mesenteric panniculitis by uterine papillary serous adenocarcinoma (UPSC): CT appearance of a case. (10416083)
1999
21
Supradiaphragmatic manifestations of papillary serous adenocarcinoma of the ovary. (10580766)
1999
22
Cytologic features of papillary serous adenocarcinoma of the uterine cervix. (9126137)
1997
23
Histologic characterization of uterine papillary serous adenocarcinoma. (7705679)
1995
24
Uterine papillary serous adenocarcinoma. A 10-case study of p53 and c-erbB-2 expression and DNA content. (7915964)
1994
25
Papillary serous adenocarcinoma of the uterine cervix: a report of three cases. (1495949)
1992
26
Papillary serous adenocarcinoma of the endometrium: a clinicopathologic study of 19 cases. (1634141)
1992
27
Primary peritoneal papillary serous adenocarcinoma: clinical and management aspects. (2013445)
1991
28
Invasive papillary serous adenocarcinoma of the endocervix in pregnancy; a case report. (1855609)
1991
29
Papillary serous adenocarcinoma of the endometrium. (3960439)
1986
30
Papillary serous adenocarcinoma. (18870241)
1948

Variations for Papillary Serous Adenocarcinoma

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Expression for genes affiliated with Papillary Serous Adenocarcinoma

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Expression patterns in normal tissues for genes affiliated with Papillary Serous Adenocarcinoma

Search GEO for disease gene expression data for Papillary Serous Adenocarcinoma.

Pathways for genes affiliated with Papillary Serous Adenocarcinoma

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Compounds for genes affiliated with Papillary Serous Adenocarcinoma

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Compounds related to Papillary Serous Adenocarcinoma according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1topotecan44 1111.2MUC16
2megestrol acetate4410.0PGR, ERBB2
3capecitabine44 50 1112.0ERBB2, PGR
4exemestane44 50 61 1112.9ERBB2, PGR
5anastrozole44 50 1111.9ERBB2, PGR
6lapatinib44 50 1111.9PGR, ERBB2
7toremifene44 1110.9ERBB2, PGR
8fulvestrant44 50 28 1112.9PGR, ERBB2
9letrozole44 50 61 1112.9ERBB2, PGR
10taxane449.9ERBB2, PGR
11leucovorin44 50 1111.8PGR, ERBB2
12raloxifene44 50 28 1112.7ERBB2, PGR
13trastuzumab44 50 1111.7ERBB2, PGR
144-hydroxytamoxifen449.6PGR, ERBB2
15geldanamycin44 50 61 1112.6ERBB2, PGR
16gnrh449.6ERBB2, NKX2-1, PGR
17progestin449.5ERBB2, PGR
18cyclophosphamide44 50 1111.5ERBB2, MUC16, PGR
19ribonucleic acid449.4KRT20, NKX2-1, PGR
20paclitaxel44 50 1111.3PGR, MUC16, ERBB2
21streptavidin449.3KRT20, KRT7
22carboplatin44 50 1111.2ERBB2, MUC16
23methotrexate50 44 1111.1PGR, ERBB2, KRT7
24steroid449.1PGR, MUC16, NKX2-1, ERBB2
25dexamethasone44 50 28 1112.1ERBB2, NKX2-1, MUC16, PGR
26mucicarmine449.1KRT20, KRT7, NKX2-1
27doxorubicin44 50 1110.8PGR, MUC16, ERBB2, KRT20
28iron44 249.7KRT20, KRT7, MUC16
29formaldehyde44 249.6NKX2-1, ERBB2, KRT7, KRT20
30b 723448.5MUC16, NKX2-1, KRT7, KRT20
31hematoxylin448.5MUC16, NKX2-1, KRT7, KRT20
32testosterone44 61 24 1111.0KRT20, KRT7, ERBB2, MUC16, PGR
33vegf448.0PGR, MUC16, ERBB2, KRT7, KRT20
34paraffin447.7KRT20, KRT7, ERBB2, NKX2-1, MUC16, PGR
35progesterone44 28 61 24 1111.7PGR, MUC16, NKX2-1, ERBB2, KRT7, KRT20
36estrogen447.7PGR, MUC16, NKX2-1, ERBB2, KRT7, KRT20
37tyrosine447.5MUC16, ANXA4, NKX2-1, ERBB2, KRT7, KRT20

GO Terms for genes affiliated with Papillary Serous Adenocarcinoma

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Cellular components related to Papillary Serous Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.0KRT20, KRT7

Molecular functions related to Papillary Serous Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.3KRT20, KRT7, ERBB2, NKX2-1, MUC16, PGR

Products for genes affiliated with Papillary Serous Adenocarcinoma

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Sources for Papillary Serous Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet