MCID: PPL007
MIFTS: 40

Papillary Serous Adenocarcinoma malady

Cancer diseases category
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Summaries for Papillary Serous Adenocarcinoma

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A papillary adenocarcinoma that derives from epithelial cells originating in glandular tissue, which form complex papillary structures with psammoma bodies.

MalaCards: Papillary Serous Adenocarcinoma, also known as serous surface papillary carcinoma, is related to adenocarcinoma and papillary carcinoma. An important gene associated with Papillary Serous Adenocarcinoma is NKX2-1 (NK2 homeobox 1). The compounds topotecan and megestrol acetate have been mentioned in the context of this disorder. Affiliated tissues include ovary, cervix and breast.

Aliases & Classifications for Papillary Serous Adenocarcinoma

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

papillary serous adenocarcinoma 8
serous surface papillary carcinoma 8 62
papillary serous cystadenocarcinoma 62
micropapillary serous carcinoma 8
papillary serous carcinoma 8


External Ids:

Disease Ontology8 DOID:2632
SNOMED-CT58 15674004, 90282004
NCIt40 C8377, C6882

Related Diseases for Papillary Serous Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Papillary Serous Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.1PGR, MUC16, ANXA4, NKX2-1, ERBB2, KRT7
2papillary carcinoma30.6PGR, MUC16, NKX2-1, ERBB2, KRT7, KRT20
3endometrial carcinoma30.4ERBB2, MUC16, PGR
4adenofibroma30.4MUC16
5neuroendocrine carcinoma30.3KRT20, KRT7, NKX2-1
6malignant mixed mullerian tumor30.3PGR, ERBB2, KRT7
7ovarian cancer30.2KRT7, ERBB2, MUC16, PGR
8breast cancer30.1KRT7, ERBB2, MUC16, PGR
9primary peritoneal carcinoma10.6
10peritonitis10.5
11ovary papillary carcinoma10.3
12hereditary breast ovarian cancer10.2
13bilateral breast cancer10.2
14panniculitis10.2
15vaginitis10.2
16gastric outlet obstruction10.2
17thrombocytosis10.2
18large cell neuroendocrine carcinoma10.2
19tuberculous peritonitis10.2
20multicentric reticulohistiocytosis10.2
21ovarian endometriosis10.2
22tuberous sclerosis10.2
23lymphangioleiomyomatosis10.2
24endocervicitis10.2
25angiomyolipoma10.2
26endometriosis10.2
27leiomyoma10.2
28pulmonary fibrosis10.2
29uterine disease10.2
30tuberous sclerosis complex10.2
31adenomyosis10.2
32cerebellar degeneration10.2
33paraneoplastic cerebellar degeneration10.2
34secretory meningioma10.1KRT7
35cystadenoma10.1KRT7
36bronchogenic cyst10.1MUC16
37cystadenocarcinoma10.1MUC16
38ovarian serous cystadenocarcinoma10.1MUC16
39merkel cell carcinoma10.1NKX2-1, KRT20
40thymus cancer10.1NKX2-1, KRT7
41bladder adenocarcinoma10.1KRT20, KRT7
42ovarian brenner tumor10.1KRT7, KRT20
43signet ring cell adenocarcinoma10.1KRT7, KRT20
44struma ovarii10.1MUC16, NKX2-1
45pancreatic ductal carcinoma10.1KRT7, KRT20
46papillary adenocarcinoma10.1MUC16, NKX2-1
47follicular adenoma10.0NKX2-1, KRT20
48teratoma10.0NKX2-1, KRT7
49pseudomyxoma peritonei10.0KRT7, KRT20
50neuroendocrine tumor10.0KRT20, NKX2-1

Graphical network of the top 20 diseases related to Papillary Serous Adenocarcinoma:



Diseases related to papillary serous adenocarcinoma

Symptoms for Papillary Serous Adenocarcinoma

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Drugs & Therapeutics for Papillary Serous Adenocarcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Papillary Serous Adenocarcinoma

Search NIH Clinical Center for Papillary Serous Adenocarcinoma

Genetic Tests for Papillary Serous Adenocarcinoma

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Anatomical Context for Papillary Serous Adenocarcinoma

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33MalaCards
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MalaCards organs/tissues related to Papillary Serous Adenocarcinoma:

33
Ovary, Cervix, Breast, Brain

Animal Models for Papillary Serous Adenocarcinoma or affiliated genes

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Publications for Papillary Serous Adenocarcinoma

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52PubMed
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Articles related to Papillary Serous Adenocarcinoma:

(show all 31)
idTitleAuthorsYear
1
Multiple brain metastases in a patient with uterine papillary serous adenocarcinoma: Treatment options for this rarely seen metastatic brain tumor. (24032086)
2013
2
Overexpression of annexin A4 is associated with chemoresistance in papillary serous adenocarcinoma of the ovary. (23290009)
2013
3
Malignant mixed mullerian tumor of endometrium coexisting with bilateral papillary serous adenocarcinoma of fallopian tube: a rare case report. (24293882)
2012
4
F-18 fluoride uptake in calcified extraosseous metastases from ovarian papillary serous adenocarcinoma. (22157054)
2012
5
Papillary-serous adenocarcinoma of the uterine cervix during tamoxifen therapy after bilateral breast cancer. (23155282)
2012
6
Papillary serous adenocarcinoma of the uterine cervix: a case report. (21614930)
2011
7
Acute gastric outlet obstruction secondary to papillary serous adenocarcinoma of the endometrium with peritoneal psammomatous implants: a case report. (19132421)
2010
8
Successful Treatment of Primary Vaginal Papillary Serous Adenocarcinoma Using Chemoradiation Followed by Brachytherapy. (20740170)
2009
9
99mTc-MDP and 18F-FDG uptake in calcified metastatic lesions from ovarian papillary serous adenocarcinoma. (19936349)
2009
10
Malignant pericardial tamponade secondary to papillary serous adenocarcinoma of the ovary. (17491236)
2007
11
A long-term survivor of repeated inguinal nodes recurrence of papillary serous adenocarcinoma of CUP: case report. (16930493)
2006
12
Pulmonary papillary serous adenocarcinoma with intraperitoneal and ovarian tumors: identification of primary site. A case report. (16515596)
2006
13
Weekly topotecan in a heavily pretreated patient with peritoneal papillary serous adenocarcinoma. (15228430)
2004
14
Papillary serous adenocarcinoma of the endometrium: CT-pathologic correlation. (15150003)
2004
15
Establishment and characterization of two cell lines (HEC-155, HEC-180) derived from uterine papillary serous adenocarcinoma. (15285295)
2004
16
Papillary serous adenocarcinoma of the ovary diagnosed after malignant pericardial tamponade and embolic stroke. (11855887)
2002
17
Cerebellar metastasis from papillary serous adenocarcinoma of the ovary mimicking MAcniA"re's disease. A case report. (11304872)
2001
18
Papillary serous adenocarcinoma of the endocervix: A rare neoplasm. Immunohistochemical profile. (11240696)
2000
19
Is uterine papillary serous adenocarcinoma a manifestation of the hereditary breast-ovarian cancer syndrome? (11104623)
2000
20
The combination paclitaxel, carboplatin and megestrol acetate is effective in women with recurrent uterine papillary serous adenocarcinoma. (10422674)
1999
21
Multiple nodular metastases in mesenteric panniculitis by uterine papillary serous adenocarcinoma (UPSC): CT appearance of a case. (10416083)
1999
22
Supradiaphragmatic manifestations of papillary serous adenocarcinoma of the ovary. (10580766)
1999
23
Cytologic features of papillary serous adenocarcinoma of the uterine cervix. (9126137)
1997
24
Histologic characterization of uterine papillary serous adenocarcinoma. (7705679)
1995
25
Uterine papillary serous adenocarcinoma. A 10-case study of p53 and c-erbB-2 expression and DNA content. (7915964)
1994
26
Papillary serous adenocarcinoma of the uterine cervix: a report of three cases. (1495949)
1992
27
Papillary serous adenocarcinoma of the endometrium: a clinicopathologic study of 19 cases. (1634141)
1992
28
Primary peritoneal papillary serous adenocarcinoma: clinical and management aspects. (2013445)
1991
29
Invasive papillary serous adenocarcinoma of the endocervix in pregnancy; a case report. (1855609)
1991
30
Papillary serous adenocarcinoma of the endometrium. (3960439)
1986
31
Papillary serous adenocarcinoma. (18870241)
1948

Variations for Papillary Serous Adenocarcinoma

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Expression for genes affiliated with Papillary Serous Adenocarcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papillary Serous Adenocarcinoma

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Pathways for genes affiliated with Papillary Serous Adenocarcinoma

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Compounds for genes affiliated with Papillary Serous Adenocarcinoma

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45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Papillary Serous Adenocarcinoma according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1topotecan45 1111.2MUC16
2megestrol acetate4510.0PGR, ERBB2
3capecitabine45 51 1112.0ERBB2, PGR
4exemestane45 51 61 1112.9ERBB2, PGR
5anastrozole45 51 1111.9ERBB2, PGR
6lapatinib45 51 1111.9PGR, ERBB2
7toremifene45 1110.9ERBB2, PGR
8fulvestrant45 51 29 1112.9PGR, ERBB2
9letrozole45 51 61 1112.9ERBB2, PGR
10taxane459.9ERBB2, PGR
11leucovorin45 51 1111.8PGR, ERBB2
12raloxifene45 51 29 1112.7ERBB2, PGR
13trastuzumab45 51 1111.7ERBB2, PGR
144-hydroxytamoxifen459.6PGR, ERBB2
15geldanamycin45 51 61 1112.6ERBB2, PGR
16gnrh459.6ERBB2, NKX2-1, PGR
17progestin459.5ERBB2, PGR
18cyclophosphamide45 51 1111.5ERBB2, MUC16, PGR
19ribonucleic acid459.4KRT20, NKX2-1, PGR
20paclitaxel45 51 1111.3PGR, MUC16, ERBB2
21streptavidin459.3KRT20, KRT7
22carboplatin45 51 1111.2ERBB2, MUC16
23methotrexate51 45 1111.1PGR, ERBB2, KRT7
24steroid459.1PGR, MUC16, NKX2-1, ERBB2
25dexamethasone45 51 29 1112.1ERBB2, NKX2-1, MUC16, PGR
26mucicarmine459.1KRT20, KRT7, NKX2-1
27doxorubicin45 51 1110.8PGR, MUC16, ERBB2, KRT20
28iron45 249.7KRT20, KRT7, MUC16
29formaldehyde45 249.6NKX2-1, ERBB2, KRT7, KRT20
30b 723458.5MUC16, NKX2-1, KRT7, KRT20
31hematoxylin458.5MUC16, NKX2-1, KRT7, KRT20
32testosterone45 61 24 1111.0KRT20, KRT7, ERBB2, MUC16, PGR
33vegf458.0PGR, MUC16, ERBB2, KRT7, KRT20
34paraffin457.7KRT20, KRT7, ERBB2, NKX2-1, MUC16, PGR
35progesterone45 29 61 24 1111.7PGR, MUC16, NKX2-1, ERBB2, KRT7, KRT20
36estrogen457.7PGR, MUC16, NKX2-1, ERBB2, KRT7, KRT20
37tyrosine457.5MUC16, ANXA4, NKX2-1, ERBB2, KRT7, KRT20

GO Terms for genes affiliated with Papillary Serous Adenocarcinoma

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16Gene Ontology
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Cellular components related to Papillary Serous Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.0KRT20, KRT7

Molecular functions related to Papillary Serous Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.3KRT20, KRT7, ERBB2, NKX2-1, MUC16, PGR

Products for genes affiliated with Papillary Serous Adenocarcinoma

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Sources for Papillary Serous Adenocarcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet