MCID: PPL020
MIFTS: 58

Papillary Thyroid Carcinoma malady

Genetic diseases, Rare diseases, Cancer diseases, Endocrine diseases categories

Summaries for Papillary Thyroid Carcinoma

About this section
Sources:
66Wikipedia, 48OMIM, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Papillary thyroid cancer or papillary thyroid carcinoma is the most common type of thyroid cancer,... more...

MalaCards: Papillary Thyroid Carcinoma, also known as thyroid carcinoma, papillary, is related to goiter and parathyroid adenoma. An important gene associated with Papillary Thyroid Carcinoma is NCOA4 (nuclear receptor coactivator 4), and among its related pathways are Pathways in cancer and Thyroid cancer. The compounds sodium iodide and regorafenib have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and endothelial, and related mouse phenotype digestive/alimentary.

Description from OMIM:48 188550

Aliases & Classifications for Papillary Thyroid Carcinoma

About this section
Sources:
9Disease Ontology, 10diseasecard, 44NIH Rare Diseases, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

papillary thyroid carcinoma 9 44 11 63
thyroid carcinoma, papillary 10 23 48
thyroid papillary carcinoma 48 46
familial nonmedullary thyroid cancer, papillary 44
nonmedullary thyroid carcinoma, papillary 44
papillary carcinoma of the thyroid gland 9
papillary carcinoma of thyroid 9
papillary thyroid cancer 46


External Ids:

Disease Ontology9 DOID:3969
NCIt41 C4035
SNOMED-CT59 4797003, 255029007
MeSH36 C536915
OMIM48 188550

Related Diseases for Papillary Thyroid Carcinoma

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Papillary Thyroid Carcinoma family:

Familial Papillary Thyroid Carcinoma

Diseases related to Papillary Thyroid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.2LGALS3, BRAF, RET
2parathyroid adenoma31.1RET, LGALS3
3papillary carcinoma31.0BRAF, LGALS3, NCOA4, RET
4thyroid cancer30.9RET, CCDC6, BRAF, LGALS3, NCOA4
5follicular adenoma30.9LGALS3
6nodular goiter30.8BRAF, RET, LGALS3
7follicular thyroid carcinoma30.8BRAF, RET, LGALS3
8thyroid adenoma30.7BRAF, RET, LGALS3
9hypothyroidism30.4RET, BRAF, LGALS3, FOXE1
10autoimmune thyroiditis30.3BRAF, LGALS3, RET
11thyroiditis11.7
12adenoma10.8
13cervicitis10.8
14struma ovarii10.7
15familial papillary thyroid carcinoma10.6
16endotheliitis10.6
17familial adenomatous polyposis10.6
18hyperparathyroidism10.6
19multiple endocrine neoplasia10.6
20primary hyperparathyroidism10.5
21multinodular goiter10.5
22graves' disease10.5
23laryngitis10.5
24pheochromocytoma10.5
25multicentric papillary thyroid carcinoma10.4
26langerhans-cell histiocytosis10.4
27paraganglioma10.4
28histiocytosis10.4
29pituitary adenoma10.4
30multiple endocrine neoplasia type 2a10.4
31adenocarcinoma10.4
32lymphadenitis10.4
33retinoblastoma10.4
34teratoma10.4
35familial papillary thyroid carcinoma with renal papillary neoplasia10.4
36adenoiditis10.3
37adenoid cystic carcinoma10.3
38leiomyosarcoma10.3
39parathyroid carcinoma10.3
40choroiditis10.3
41familial medullary thyroid carcinoma10.3
42laryngeal squamous cell carcinoma10.3
43meningioma10.3
44warthin tumor10.3
45thyroid carcinoma, papillary, with papillary renal neoplasia10.3
46thyroid carcinoma, papillary, somatic10.3
47dermatomyositis10.3
48ovary papillary carcinoma10.2
49adenocarcinoma in situ10.2
50lymphoblastic leukemia10.2

Graphical network of the top 20 diseases related to Papillary Thyroid Carcinoma:



Diseases related to papillary thyroid carcinoma

Symptoms for Papillary Thyroid Carcinoma

About this section
Sources:
48OMIM
See all sources

Symptoms by clinical synopsis from OMIM:

188550

Clinical features from OMIM:

188550

Drugs & Therapeutics for Papillary Thyroid Carcinoma

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Papillary Thyroid Carcinoma

Drug clinical trials:

Search ClinicalTrials for Papillary Thyroid Carcinoma

Search NIH Clinical Center for Papillary Thyroid Carcinoma

Search CenterWatch for Papillary Thyroid Carcinoma

Genetic Tests for Papillary Thyroid Carcinoma

About this section
Sources:
23GTR
See all sources

Genetic tests related to Papillary Thyroid Carcinoma:

id Genetic test Affiliating Genes
1 Papillary Thyroid Carcinoma23

Anatomical Context for Papillary Thyroid Carcinoma

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Papillary Thyroid Carcinoma:

34
Thyroid, Lymph node, Endothelial, Lung, Pituitary, Bone, Breast, Colon, Testes, Kidney, Ovary, Heart, Pancreas, Trachea, Brain, B cells, Monocytes, Liver

Animal Models for Papillary Thyroid Carcinoma or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Papillary Thyroid Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.0TRIM33, FOXE1, LGALS3, RET, BRAF

Publications for Papillary Thyroid Carcinoma

About this section
Sources:
53PubMed
See all sources

Articles related to Papillary Thyroid Carcinoma:

(show top 50)    (show all 1069)
idTitleAuthorsYear
1
Expression and clinical significance of STIP1 in papillary thyroid carcinoma. (24163084)
2013
2
Tumor size measured by preoperative ultrasonography and postoperative pathologic examination in papillary thyroid carcinoma: relative differences according to size, calcification and coexisting thyroiditis. (23880922)
2013
3
Establishing a familial basis for papillary thyroid carcinoma using the Utah Population Database. (24092278)
2013
4
Follicular variant of papillary thyroid carcinoma is a unique clinical entity: a population-based study of 10,740 cases. (23477346)
2013
5
Extranodal extension of metastatic papillary thyroid carcinoma: correlation with biochemical endpoints, nodal persistence, and systemic disease progression. (23421588)
2013
6
Tall Cell Variant Papillary Thyroid Carcinoma Arising from Struma Ovarii. (24246339)
2013
7
A rare coexistence of thyroid lymphoma with papillary thyroid carcinoma. (24005594)
2013
8
Surgical complications and recurrence after central neck dissection in cN0 papillary thyroid carcinoma. (23886706)
2013
9
Candidates for Limited Lateral Neck Dissection among Patients with Metastatic Papillary Thyroid Carcinoma. (24337241)
2013
10
Cutaneous metastasis of papillary thyroid carcinoma to the thyroidectomy scar. (23676148)
2013
11
Comparative serum proteomic analysis identified afamin as a downregulated protein in papillary thyroid carcinoma patients with non-131I-avid lung metastases. (24089082)
2013
12
Metastatic papillary thyroid carcinoma to the kidney: report of two cases mimicking primary renal cell carcinoma and review of the literature. (23255036)
2013
13
Cribriform morular variant of papillary thyroid carcinoma: clinical and cytomorphological features on fine-needle aspiration. (23406819)
2013
14
Lymph node metastasis between sternocleidomastoid and sternohyoid muscle in clinically node-positive papillary thyroid carcinoma. (22927223)
2013
15
Papillary thyroid carcinoma associated to squamous cell carcinoma. (24332292)
2013
16
Unusual muscular metastases from papillary thyroid carcinoma detected by fluorine-18-fluorodeoxyglucose PET/MRI. (23596135)
2013
17
Papillary thyroid carcinoma-like tumor of the kidney: a case report. (22158951)
2012
18
Role of Caspase 8, Caspase 9 and Bcl-2 polymorphisms in papillary thyroid carcinoma risk in Han Chinese population. (22120515)
2012
19
Focal bronchiectasis causing abnormal pulmonary radioiodine uptake in a patient with well-differentiated papillary thyroid carcinoma. (23097725)
2012
20
Basal STAT3 activities are negatively correlated with tumor size in papillary thyroid carcinomas. (21897114)
2012
21
Tuberculous cervical lymphadenitis masquerding as metastatis from papillary thyroid carcinoma. (23843822)
2012
22
BRAF mutation in papillary thyroid carcinoma. (22993650)
2012
23
A novel definition of extrathyroidal invasion for patients with papillary thyroid carcinoma for predicting prognosis. (22402972)
2012
24
Soluble human leukocyte antigen-g and its insertion/deletion polymorphism in papillary thyroid carcinoma: novel potential biomarkers of disease? (22930786)
2012
25
Coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma: the influence of lymph node metastasis. (21837696)
2011
26
The preeminence of growth pattern and invasiveness and the limited influence of BRAF and RAS mutations in the occurrence of papillary thyroid carcinoma lymph node metastases. (21796448)
2011
27
BRAF(V600E) mutation analysis from May-GrA1nwald Giemsa-stained cytological samples as an adjunct in identification of high-risk papillary thyroid carcinoma. (21948220)
2011
28
Somatostatin receptor 2 expression determined by immunohistochemistry in cold thyroid nodules exceeds that of hot thyroid nodules, papillary thyroid carcinoma, and Graves' disease. (20450431)
2010
29
Rearrangements of NTRK1 gene in papillary thyroid carcinoma. (19883730)
2010
30
Usefulness of the determination of thyroglobulin in lymph node aspirates of patients with papillary thyroid carcinoma and positive antithyroglobulin antibodies]. (20096208)
2009
31
Lack of GNAQ hotspot mutation in papillary thyroid carcinomas. (19445628)
2009
32
RET/PTC rearrangements arising from a small population of papillary thyroid carcinoma cells, possible candidate for passenger mutation. (19495791)
2009
33
BRAF mutation in solid cell nest hyperplasia associated with papillary thyroid carcinoma. A precursor lesion? (19269016)
2009
34
Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation. (19958951)
2009
35
BRAFV600E mutation and X-linked inhibitor of apoptosis expression in papillary thyroid carcinoma. (19355825)
2009
36
Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism. (19491068)
2009
37
Association of genetic polymorphisms and haplotypes in hMLH1 and hMSH3 gene with the risk of papillary thyroid carcinoma]. (18683134)
2008
38
A papillary thyroid carcinoma case associated with hereditary colon carcinoma due to familial adenomatous polyposis with no hereditary mutation finding. (15834731)
2007
39
The oncogene BRAF V600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I- targeting to the membrane. (16601293)
2006
40
Gene expression in poorly differentiated papillary thyroid carcinomas. (16676402)
2006
41
Increased expression of vascular endothelial growth factor C in papillary thyroid carcinoma correlates with cervical lymph node metastases. (16299237)
2005
42
Ret/PTC activation does not influence clinical and pathological features of adult papillary thyroid carcinomas. (12720532)
2003
43
Breast tumor resembling the tall cell variant of papillary thyroid carcinoma: report of 5 cases. (12883243)
2003
44
Nuclear envelope organization in papillary thyroid carcinoma. (11193183)
2001
45
High prevalence of RET tyrosine kinase activation in Mexican patients with papillary thyroid carcinomas. (11579677)
2001
46
Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma. (10697956)
2000
47
Oncogene profile of papillary thyroid carcinoma. (9889797)
1999
48
Papillary thyroid carcinoma, parathyroid adenoma, and unexplained hypercalcitoninemia: an unusual presentation of multiple endocrine neoplasia type 2A? (9777749)
1998
49
Antitumor actions of cytokines on new human papillary thyroid carcinoma cell lines. (8675585)
1996
50
Multiple primary malignant tumours: gemistocytic astrocytoma with leptomeningeal spreading and papillary thyroid carcinoma. A case report. (2251958)
1990

Variations for Papillary Thyroid Carcinoma

About this section
Sources:
1 National Center for Biotechnology Information (Clinvar)
See all sources

Clinvar genetic disease variations for Papillary Thyroid Carcinoma:

1
id Gene Name Type Significance SNP ID Assembly Location
1BRAFNM_004333.4(BRAF): c.1799T> A (p.Val600Glu)single nucleotide variantPathogenicrs113488022GRCh37Chr 7, 140453136: 140453136

Expression for genes affiliated with Papillary Thyroid Carcinoma

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Papillary Thyroid Carcinoma

Search GEO for disease gene expression data for Papillary Thyroid Carcinoma.

Pathways for genes affiliated with Papillary Thyroid Carcinoma

About this section
Sources:
51PathCards, 31KEGG
See all sources

Pathways related to Papillary Thyroid Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1NCOA4, CCDC6, RET, BRAF
210.1NCOA4, CCDC6, RET, BRAF

Compounds for genes affiliated with Papillary Thyroid Carcinoma

About this section
Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB
See all sources

Compounds related to Papillary Thyroid Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sodium iodide4610.3BRAF, RET
2regorafenib52 1211.2RET, BRAF
3agar4610.2BRAF, LGALS3, RET
4iodide46 2511.0FOXE1, BRAF
5tyrosine4610.0NCOA4, GOLGA5, BRAF, RET, LGALS3, CCDC6

GO Terms for genes affiliated with Papillary Thyroid Carcinoma

About this section
Sources:
17Gene Ontology
See all sources

Biological processes related to Papillary Thyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription, DNA-templatedGO:04589310.1TRIM24, NCOA4, FOXE1, RET

Products for genes affiliated with Papillary Thyroid Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Papillary Thyroid Carcinoma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet