Papillary Thyroid Carcinoma malady

Wikipedia: Papillary thyroid cancer or papillary thyroid carcinoma is the most common type of thyroid cancer,...⁴⁴ more...

MalaCards: Papillary Thyroid Carcinoma, also known as thyroid papillary carcinoma, is related to carcinoma and thyroiditis. An important gene associated with Papillary Thyroid Carcinoma is NCOA4 (nuclear receptor coactivator 4), and among its related pathways are Renal cell carcinoma and Apoptosis and survival Role of CDK5 in neuronal death and survival. The compounds glycogen and methionine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and colon, and related mouse phenotypes are normal and embryogenesis.

OMIM: 188550

Aliases & Descriptions:

papillary thyroid carcinoma 6 8 43 thyroid papillary carcinoma 7 33 32 papillary carcinoma of the thyroid gland 6 papillary thyroid carcinoma (disorder) 6

papillary carcinoma of thyroid 6 thyroid carcinoma, papillary 33 carcinoma, papillary 43 thyroid carcinoma 43

Diseases related to papillary thyroid carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 905)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	43.4	PIK3CA, NCOA4, RET, KIF23, KIAA1671, PCNA
2	thyroiditis	43.4	PIK3CA, NCOA4, RET, KIF23, KIAA1671, PCNA
3	thyroid carcinoma	34.8	PIK3CA, RET, PCNA, RB1, SELE, VIM
4	follicular adenoma	34.2	RET, RAP1A, RAP1B, LGALS3, S100A4, MKI67
5	struma ovarii	34.1	RET, BRAF, HNF1A, TSHR, TG, NKX2-1
6	thyroid cancer	33.9	RET, SERPINB5, BRAF, PAX8, LGALS1, LGALS3
7	papillary renal cell carcinoma	33.4	PCNA, VEGFA, VEGFC, MUC1, CD44, MMP11
8	familial medullary thyroid carcinoma	33.2	RET, BRAF, RAF1, LGALS3, MEN1, CALCA
9	nonencapsulated sclerosing carcinoma	33.0	NCOA4, RET, SERPINB5, BRAF, VEGFC, RARB
10	thyroid medullary carcinoma	33.0	RET, BRAF, VEGFC, PAX8, LGALS3, CDH3
11	anaplastic carcinoma	32.6	RET, VIM, BRAF, PAX8, LGALS1, LGALS3
12	folliculitis	32.4	KIAA1671, NACA, ZFP36L2, BCL6, MPP1, ARPP19
13	multiple endocrine neoplasia	32.0	RET, CDKN1A, CDKN1B, CDKN2A, CDKN1C, CDH1
14	goiter	31.9	RET, SELE, BRAF, VEGFA, VEGFC, LMOD1
15	hypothyroidism	31.7	LEP, GHRL, TRH, TPO, LSL, TSHR
16	multinodular goiter	31.6	VEGFA, LEP, IL1B, IFNG, CALCA, HRAS
17	neuroendocrine tumor	31.5	RET, RAF1, PAX8, MKI67, MEN1, IFI27
18	thyrotoxicosis	31.4	LMOD1, LEP, CD36, CALCA, GHRL, TRH
19	thyroid cancer, follicular	31.2	PIK3CA, CDKN1A, CALCA, PTEN, PPARG, EGF
20	thyroid adenoma	31.1	PIK3CA, RET, BRAF, RAF1, BCL2, LGALS1
21	neuroendocrine carcinoma	31.1	MUC1, CDH1, MMP7, MEN1, CALCA, TP63
22	carcinoid tumors	31.0	RET, PCNA, RAF1, CLDN16, PAX8, BCL2
23	squamous cell carcinoma	30.9	PAK1, LGALS1, LGALS3, CD44, CDH1, MMP7
24	cushing's syndrome	30.8	RET, PCNA, BCL2, LEP, MUC1, BAX
25	nodular goiter	30.7	IL6R, IFNG, CALCA, TRH, TPO, TSHR
26	thyroid cancer, anaplastic	30.6	PIK3CA, RET, BRAF, RAN, PAX8, BCL2L1
27	parathyroid adenoma	30.4	RET, PCNA, VDR, BCL2, LGALS3, CDKN1B
28	familial adenomatous polyposis	29.7	PCNA, RB1, VIM, BRAF, RARB, MUC1
29	renal cell carcinoma	29.5	PIK3CA, RET, PCNA, SELP, VIM, BRAF
30	paraganglioma	29.4	RET, PCNA, VIM, LIF, BCL2, LGALS3
31	primary hyperparathyroidism	29.2	RET, SELE, VDR, LEP, LBR, CD36
32	hepatitis	29.1	SELP, FASLG, FAS, HLA-DRB1, TXN, PDGFB
33	hemangioma	28.8	RET, RB1, SELE, VEGFA, LMOD1, MUC1
34	graves' disease	28.3	SELE, VDR, LMOD1, PAX8, BCL2, LGALS3
35	mediastinitis	27.7	PCNA, SELE, VIM, VEGFC, BCL6, MLH1
36	eosinophilia	27.5	MUC1, IL1B, IL6, FAS, MAPK8, MAPK1
37	hyperthyroidism	27.3	SELE, SELP, VDR, LMOD1, PAX8, LEP
38	cervicitis	27.1	PIK3CA, RET, PCNA, RB1, SELE, SERPINB5
39	pheochromocytoma	26.8	RET, VEGFA, RAF1, RAN, LIF, BCL2
40	adenoma	26.7	PIK3CA, RET, PCNA, RB1, SERPINB5, VIM
41	papilloma	26.6	RET, PCNA, RB1, VIM, NAA15, BRAF
42	adenomatous polyposis coli	26.5	RAN, BCL2, MUC1, CDKN1A, CDH1, MLH1
43	pituitary adenoma	26.5	RET, PCNA, RB1, VIM, BRAF, VEGFA
44	poems syndrome	26.4	VEGFA, CD36, IL1B, IL6, TNF, TIMP1
45	hyperparathyroidism	26.0	RET, PCNA, SELE, VEGFA, VDR, LEP
46	cholestasis	25.9	PCNA, VEGFA, BCL2, BAX, MKI67, IL6
47	amyloidosis	25.9	RET, BCL2, MMP9, IL1B, IL6, FAS
48	lung carcinoma	25.8	PIK3CA, PCNA, RB1, SELENBP1, SERPINB5, BRAF
49	herpes simplex	25.2	PIK3CA, PCNA, VIM, NAA15, VEGFA, VDR
50	retinoblastoma	24.9	PIK3CA, PCNA, RB1, VIM, VEGFA, VEGFC

Clinical features from OMIM: 188550

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to papillary thyroid carcinoma:

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MGI Mouse Phenotypes related to papillary thyroid carcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal phenotype	MP:0002873	11.3	RET, SELE, BRAF, VEGFA, RARB, LGALS1
2	embryogenesis phenotype	MP:0005380	11.2	PIK3CA, RET, SERPINB5, VIM, NACA, BRAF
3	endocrine/exocrine gland phenotype	MP:0005379	11.2	RET, MYT1, PAX8, CITED1, CDKN1B, CDH3
4	hematopoietic system phenotype	MP:0005397	11.0	PCNA, BRAF, RAP1A, RAP1B, ZFP36L2, BCL2
5	renal/urinary system phenotype	MP:0005367	11.0	RET, SELP, BRAF, RARB, CLDN16, ZFP36L2
6	immune system phenotype	MP:0005387	10.8	SELP, VIM, BRAF, VDR, RAP1A, RAF1
7	craniofacial phenotype	MP:0005382	10.8	LMNB1, BMP1, PAX8, LBR, CDKN1C, MMP16
8	respiratory system phenotype	MP:0005388	10.8	RET, SELP, LIF, BCL6, LEPR, LDHA
9	mortality/aging	MP:0010768	10.3	PIK3CA, RET, RB1, SELE, SELP, SERPINB5
10	no phenotypic analysis	MP:0003012	10.2	RET, PCNA, RB1, VEGFA, PAX8, LEPR
11	limbs/digits/tail phenotype	MP:0005371	10.1	RET, RB1, VEGFA, VDR, RARB, LEP
12	growth/size phenotype	MP:0005378	9.8	PIK3CA, RET, RB1, SELE, SELP, NACA
13	other phenotype	MP:0005395	9.7	RARB, LEPR, QPCT, CDKN2A, ITGB1, MMP14
14	liver/biliary system phenotype	MP:0005370	9.4	VEGFA, LIF, BCL6, MTF1, MST1, CD36
15	integument phenotype	MP:0010771	9.1	RB1, SELP, BRAF, LMNB1, RAF1, LIF
16	nervous system phenotype	MP:0003631	9.0	RB1, SELP, BRAF, LMNB1, RAP1A, RAF1
17	pigmentation phenotype	MP:0001186	8.8	RB1, BRAF, BCL2, LEP, CDKN1B, CDKN2A
18	hearing/vestibular/ear phenotype	MP:0005377	8.6	RB1, VDR, RARB, PAX8, BCL2, BAX
19	behavior/neurological phenotype	MP:0005386	8.5	PIK3CA, RB1, SELE, SELP, VIM, BRAF
20	digestive/alimentary phenotype	MP:0005381	8.3	RET, RB1, BRAF, VEGFA, VDR, BMP1
21	skeleton phenotype	MP:0005390	8.2	RB1, NACA, BRAF, VEGFA, VDR, BMP1
22	reproductive system phenotype	MP:0005389	7.8	PIK3CA, RET, VEGFA, VDR, RARB, RAP1B
23	adipose tissue phenotype	MP:0005375	7.1	PIK3CA, RB1, BRAF, LIF, BCL2, LEP
24	tumorigenesis	MP:0002006	7.0	PIK3CA, RET, RB1, BRAF, ZFP36L2, BCL2
25	homeostasis/metabolism phenotype	MP:0005376	5.8	PIK3CA, RET, RB1, SELE, SELP, VIM
26	cellular phenotype	MP:0005384	5.6	PIK3CA, RET, PCNA, RB1, SELE, SELP
27	cardiovascular system phenotype	MP:0005385	5.4	PIK3CA, RET, RB1, SELE, SELP, VIM
28	muscle phenotype	MP:0005369	5.2	PIK3CA, RET, RB1, VIM, NACA, BRAF
29	vision/eye phenotype	MP:0005391	4.7	PIK3CA, RB1, SELE, SELP, VIM, BRAF

Articles related to papillary thyroid carcinoma:

(show top 50)    (show all 444)

id	Title	Authors	Year	Affiliating Genes
1	Quantitative analysis of the expression of TGF-alpha and EGFR in papillary thyroid carcinoma: clinicopathological relevance. (21240064)	Lam A.K.... Lo C.Y.	2011	EGFR, TGFA
2	Transcription and promoter hypermethylation of thyro id stimulating hormone receptor gene in human papillary thyroid carcinoma (20117998)	Dai Y.L.... Li J.	2010	TSHR
3	Nonconventional papillary thyroid carcinomas with ple omorphic tumor giant cells: a diagnostic pitfall with anaplastic carcinoma. (20414675)	Hommell-Fontaine J.... Decaussin-Petrucci M.	2010	TG
4	Role of PTPRJ genotype in papillary thyroid carcinoma risk. (20823296)	Iuliano R.... Fusco A.	2010	PTPRJ
5	The Ca2+-calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC. (19903742)	Rusciano M.R.... Vitale M.	2010	MAPK1, CAMK2G
6	Mutational and immunohistochemical study of the PI3K/ Akt pathway in papillary thyroid carcinoma in Greece. (20186503)	Sozopoulos E.... Tseleni-Balafouta S.	2010	AKT2, AKT1, PDPK1
7	Detection and molecular characterization of a novel BRAF activated domain mutation in follicular variant of papillary thyroid carcinoma. (19200582)	Santarpia L.... El-Naggar A.K.	2009	BRAF
8	Correlation between thyroid-stimulating hormone-pero xiredoxin1 signaling pathway and invasion of papillary thyroid carcinoma (19558833)	Liu X.... Gao M.	2009	HIF1A, PRDX1, TXN
9	Expression of mucin-l and beta-catenin in papillary thyroid carcinoma and the clinical significance thereof (19567117)	He F.... Dong X.H.	2009	CTNNB1, MUC1
10	The expression of monocyte chemotactic protein-1 in papillary thyroid carcinoma is correlated with lymph node metastasis and tumor recurrence. (19072670)	Tanaka K.... Sonoo H.	2009	CCL2
11	BRAF V600E mutation analysis increases diagnostic acc uracy for papillary thyroid carcinoma in fine-needle aspiration biopsies. (19574281)	Zatelli M.C.... degli Uberti E.C.	2009	BRAF
12	Cytoplasmic localization of Jab1 and p27 Kip1 might b e associated with invasiveness of papillary thyroid carcinoma. (19461157)	Ahn J.... Chung Y.J.	2009	CDKN1B, COPS5
13	BRAF Mutation in Papillary Thyroid Carcinoma in a Japanese Population: Its Lack of Correlation with High-Risk Clinicopathological Features and Disease-Free Survival of Patients. (18840924)	Ito Y.... Miyauchi A.	2008	BRAF
14	Expression of p21cip1, p27kip1, and p16INk4a cyclin-dependent kinase inhibitors in papillary thyroid carcinoma: correlation with clinicopathological factors. (18766473)	Zafon C.... Mesa J.	2008	CDKN1A, CDKN1B, CDKN2A
15	The potential clinical relevance of serum vascular endothelial growth factor (VEGF) and VEGF-C in recurrent papillary thyroid carcinoma. (19041000)	Yu X.M.... Luk J.M.	2008	VEGFA, VEGFC, TG
16	Low-level genomic instability is a feature of papillary thyroid carcinoma: an array comparative genomic hybridization study of laser capture microdissected papillary thyroid carcinoma tumors and clonal cell lines. (17227125)	Finn S.... Sheils O.	2007	RET, BRAF, PDGFB
17	Fine-needle aspiration molecular analysis for the diagnosis of papillary thyroid carcinoma through BRAF V600E mutation and RET/PTC rearrangement. (17727338)	Pizzolanti G.... Giordano C.	2007	RET, BRAF
18	Tumor suppressor LKB1 inhibits activation of signal transducer and activator of transcription 3 (STAT3) by thyroid oncogenic tyrosine kinase rearranged in transformation (RET)/papillary thyroid carcinoma (PTC). (17761947)	Kim D.W.... Shong M.	2007	CCND1, STAT3, BCL2L1
19	HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma. (17639057)	Ciampi R.... Nikiforov Y.E.	2007	RET, HOOK3
20	Different structural components of conventional papillary thyroid carcinoma display mostly identical BRAF status. (17044028)	Abrosimov A.... Yamashita S.	2007	BRAF
21	Lymphatic mapping establishes the role of BRAF gene mutation in papillary thyroid carcinoma. (17060774)	Kim J.... Hoon D.S.	2006	BRAF
22	BRAF mutation is unusual in chronic lymphocytic thyroiditis-associated papillary thyroid carcinomas and absent in non-neoplastic nuclear atypia of thyroiditis. (17308360)	Sargent R.... Hunt J.L.	2006	BRAF
23	Quantitative and qualitative differences in protein expression between papillary thyroid carcinoma and normal thyroid tissue. (16788983)	Brown L.M.... Haugen B.R.	2006	HSPA5, MSN, SELENBP1
24	The role of immunolocalization of CD57 and GLUT-1 in cell blocks in fine-needle aspiration diagnosis of papillary thyroid carcinoma. (16944537)	Chandan V.S.... Khurana K.K.	2006	SLC2A1
25	BRAF mutation and AKAP9 expression in sporadic papillary thyroid carcinomas. (16753739)	Lee J.H.... Chae Y.S.	2006	BRAF, AKAP9
26	The role of positron emission tomography/computed tomography in the management of recurrent papillary thyroid carcinoma. (15689742)	Nahas Z.... Tufano R.P.	2005	TG
27	Parapharyngeal metastasis from papillary thyroid carcinoma: a case diagnosed by thyroglobulin measurement in peroral fine-needle aspiration of a cystic metastatic lymph node. (15829073)	Tomoda C.... Miyauchi A.	2005	TG
28	Gene profiling reveals specific oncogenic mechanisms and signaling pathways in oncocytic and papillary thyroid carcinoma. (15806164)	Baris O.... Malthiery Y.	2005	ACTN2, CTNNA1
29	Mutations of the BRAF gene in papillary thyroid carcinoma in a Korean population. (15515191)	Kim K.H.... Kang D.Y.	2004	BRAF
30	Peroxisome proliferator activated receptor gamma immunohistochemical expression in human papillary thyroid carcinoma tissues. Possible relationship to lymph node metastasis. (15274390)	Galusca B.... Estour B.	2004	PPARG
31	BRAF and endocrine tumors: mutations are frequent in papillary thyroid carcinomas, rare in endocrine tumors of the gastrointestinal tract and not detected in other endocrine tumors. (15613458)	Perren A.... Komminoth P.	2004	BRAF, MAPK10
32	Topoisomerase II alpha and telomerase expression in papillary thyroid carcinomas. (14736527)	Karayan-Tapon L.... Kraimps J.L.	2004	TOP2A
33	Effect of papillary thyroid carcinoma related gene PTC1 on subcellular localization and function of ATM cell (15142440)	Tie Y.... Sun Z.X.	2004	PTCH1
34	RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1. (12738763)	Kim D.W.... Shong M.	2003	SRC, PDK1
35	BRAF mutation in papillary thyroid carcinoma. (12697856)	Cohen Y.... Sidransky D.	2003	BRAF
36	Cytokeratin 19 immunolocalization in cell block preparation of thyroid aspirates. An adjunct to fine-needle aspiration diagnosis of papillary thyroid carcinoma. (12708901)	Khurana K.K.... Baloch Z.W.	2003	KRT19
37	Diagnosis of the follicular variant of papillary thyroid carcinoma. Significance of immunohistochemistry (12743496)	GuyActant S.... Saint-AndrAc J.P.	2003	RET, KRT19
38	Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient. (12787916)	Saenko V.... Yamashita S.	2003	RET, TKT, TRIM27
39	Distinction between papillary thyroid hyperplasia and papillary thyroid carcinoma by immunohistochemical staining for cytokeratin 19, galectin-3, and HBME-1. (12746563)	Casey M.B.... Lloyd R.V.	2003	LGALS3, KRT19
40	Activation of signal transducer and activator of transcription 3 by oncogenic RET/PTC (rearranged in transformation/papillary thyroid carcinoma) tyrosine kinase: roles in specific gene regulation and cellular transformation. (12637586)	Hwang J.H.... Shong M.	2003	RET, CCND1, STAT3
41	Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells. (14557485)	Xu J.... Hershman J.M.	2003	NNMT
42	Specific haplotypes of the RET proto-oncogene are over-represented in patients with sporadic papillary thyroid carcinoma. (11950855)	Lesueur F.... Romeo G.	2002	RET
43	Immunostaining for ret oncogene proteins in papillary thyroid carcinoma: a correlation of ret immunoreactivity and potential of lymph node metastasis. (11575855)	Mai K.T.... Odell P.F.	2001	RET
44	Gene expression in papillary thyroid carcinoma reveals highly consistent profiles. (11752453)	Huang Y.... de la Chapelle A.	2001	FABP12
45	Co-overexpression of p53 protein and epidermal growth factor receptor in human papillary thyroid carcinomas correlated with lymph node metastasis, tumor size and clinicopathologic stage. (10536170)	Chen B.K.... Sonobe H.	1999	EGFR
46	Prognostic value of e-cadherin in papillary thyroid carcinoma (9551263)	Walgenbach S.... Junginger T.	1998	CDH1
47	Expression of Ret/PTC1, -2, -3, -delta3 and -4 in Ger man papillary thyroid carcinoma. (9528832)	Mayr B.... Brabant G.	1998	RET, NCOA4
48	Tall cell variant of papillary thyroid carcinoma: a reassessment and immunohistochemical study with comparison to the usual type of papillary carcinoma of the thyroid. (8712296)	Ostrowski M.L.... Merino M.J.	1996	MUC1, CEACAM4
49	RET activation in adult and childhood papillary thyroid carcinoma using a reverse transcriptase-n-polymerase chain reaction approach on archival-nested material. (8761374)	Williams G.H.... Williams E.D.	1996	RET
50	Evidence against involvement of APC mutation in papillary thyroid carcinoma. (7946597)	Curtis L.... Wynford-Thomas D.	1994	APC

Genes related to papillary thyroid carcinoma according to GeneCards:

(show top 50)    (show all 297)

id	Symbol	Description	Score	GeneCards Section Context
1	NCOA4	nuclear receptor coactivator 4	11.1	Summaries, Publications, Functions
2	PCM1	pericentriolar material 1	11.1	Publications, Summaries
3	PTCPRN	Papillary thyroid carcinoma with papillary renal neoplasia	11.1	Publications, Aliases & Descriptions
4	CCDC6	coiled-coil domain containing 6	11.1	Aliases & Descriptions, Publications
5	PTCSC1	papillary thyroid carcinoma susceptibility candidate 1 (non-protein coding)	11.0	Aliases & Descriptions
6	PTCSC3	papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding)	11.0	Aliases & Descriptions
7	RET	ret proto-oncogene	11.0	Publications
8	NAMA	non-protein coding RNA, associated with MAP kinase pathway and growth arrest	11.0	Publications
9	MIR34B	microRNA 34b	11.0	Publications
10	MIR181A1	microRNA 181a-1	11.0	Publications
11	MIR146B	microRNA 146b	11.0	Publications
12	MIR130B	microRNA 130b	11.0	Publications
13	MUC15	mucin 15, cell surface associated	11.0	Publications
14	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.0	Publications
15	MIR222	microRNA 222	11.0	Publications
16	PPP1R16A	protein phosphatase 1, regulatory subunit 16A	11.0	Publications
17	MT1G	metallothionein 1G	11.0	Publications
18	MIR221	microRNA 221	11.0	Publications
19	NDUFC2	NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa	11.0	Publications
20	CST6	cystatin E/M	11.0	Publications
21	PSMG1	proteasome (prosome, macropain) assembly chaperone 1	11.0	Publications
22	CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	11.0	Publications
23	KRT19	keratin 19	11.0	Publications
24	ZFP36L2	zinc finger protein 36, C3H type-like 2	11.0	Publications
25	MIR146A	microRNA 146a	11.0	Publications
26	NKX2-1	NK2 homeobox 1	11.0	Publications
27	TG	thyroglobulin	11.0	Publications
28	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
29	FIGF	c-fos induced growth factor (vascular endothelial growth factor D)	11.0	Publications
30	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	11.0	Publications
31	MFF	mitochondrial fission factor	11.0	Publications
32	CRABP1	cellular retinoic acid binding protein 1	11.0	Publications
33	RPL15	ribosomal protein L15	11.0	Publications
34	CXCL14	chemokine (C-X-C motif) ligand 14	11.0	Publications
35	CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	11.0
36	CIB1	calcium and integrin binding 1 (calmyrin)	11.0	Publications
37	NNMT	nicotinamide N-methyltransferase	11.0	Publications
38	NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	11.0	Publications
39	FXYD5	FXYD domain containing ion transport regulator 5	11.0	Publications
40	ECM1	extracellular matrix protein 1	11.0	Publications
41	DUSP5	dual specificity phosphatase 5	11.0	Publications
42	NACA	nascent polypeptide-associated complex alpha subunit	11.0	Publications
43	SLC25A32	solute carrier family 25 (mitochondrial folate carrier) , member 32	11.0	Disorders
44	SELENBP1	selenium binding protein 1	11.0	Publications
45	ARPP19	cAMP-regulated phosphoprotein, 19kDa	11.0	Publications
46	TFF3	trefoil factor 3 (intestinal)	11.0	Publications
47	ZNF121	zinc finger protein 121	11.0
48	ZNF20	zinc finger protein 20	11.0	Disorders
49	TFG	TRK-fused gene	11.0	Functions, Publications
50	DHRS3	dehydrogenase/reductase (SDR family) member 3	11.0	Publications

Pathways related to papillary thyroid carcinoma according to GeneDecks:

(show top 50)    (show all 359)

id	Pathway	Score	Top Affiliating Genes
1	Renal cell carcinoma20	11.0	RAP1A, RAF1, RAP1B, RAPGEF1, PAK1, FIGF
2	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.7	BCL2, AKT3, ERBB3, NTRK1
3	Cell adhesion PLAU signaling10	10.5	PIK3CA, RAF1, ITGB1, MET, HRAS, AKT2
4	NGF Pathway36	10.4	BRAF, RAP1A, RAF1, RAP1B, BAX, MAPK8
5	Development HGF signaling pathway10	10.3	PIK3CA, RAP1A, RAF1, RAPGEF1, MET, MAPK8
6	Colorectal cancer20	10.2	BRAF, MSH3, MAPK8, AKT3, TGFB1, TGFBR2
7	Development Neurotrophin family signaling10	10.2	PIK3CA, BRAF, RAP1A, RAF1, RAPGEF1, BAX
8	ErbB2-ErbB3 Heterodimers36	10.2	RAF1, ERBB3, ERBB2, NRG1, PDPK1, STAT1
9	Development_Ligand-independent activation of ESR1 and ESR241	10.1	PIK3CA, RAF1, MAPK3, CCND1, HRAS, AKT1
10	Signal transduction_AKT signaling41	10.1	PIK3CA, PCNA, BCL2L1, BAX, CDKN1A, CDKN1B
11	Cytoskeleton remodeling_FAK signaling41	10.1	PIK3CA, VEGFA, RAP1A, RAF1, RAPGEF1, PAK1
12	Non-small cell lung cancer20	10.0	PIK3CA, RB1, BRAF, RAF1, CDKN2A, MAPK1
13	HGF Pathway36	9.9	RB1, RAP1A, RAF1, RAP1B, RAPGEF1, PAK1
14	TRKA Signaling36	9.9	BRAF, RAP1A, RAF1, RAP1B, BAX, MAPK8
15	VEGF Signaling Pathway34	9.9	VEGFA, VEGFC, RAF1, FLT1, FGF2, MAPK8
16	Akt Signaling36	9.6	VEGFC, BMP1, RAF1, LIF, ITGB4, FIGF
17	ErbB Family Pathway36	9.6	BRAF, RAF1, PAK1, MAPK8, MAPK3, MAPK10
18	EGF Pathway36	9.6	BRAF, RAF1, PAK1, MUC1, CDH1, MAPK8
19	Signal transduction PTEN pathway10	9.5	PIK3CA, PCNA, RAF1, CDKN1A, ITGB1, MAPK3
20	Focal adhesion20	9.5	PIK3CA, BRAF, VEGFC, RAP1A, RAF1, RAP1B
21	eNOS Signaling36	9.3	BMP1, FIGF, MET, CASP3, AKT1, ESR2
22	CDC42 Pathway36	9.3	RAF1, PAK1, CDH1, ITGB1, ITGB4, FLT1
23	Development_EGFR signaling pathway41	9.3	PIK3CA, RAF1, PAK1, MMP2, MMP9, MAPK8
24	Hepatitis C20	9.2	PIK3CA, BRAF, RAF1, CLDN16, CDKN1A, MAPK8
25	Angiogenesis3	9.1	SERPINB5, VEGFC, ITGB1, MMP2, MMP7, MMP9
26	PEDF Induced Signaling36	9.1	BRAF, BMP1, RAF1, LIF, BCL2, BCL2L1
27	eIF2 Pathway36	9.0	BRAF, VEGFC, BMP1, RAF1, FIGF, FGF2
28	Paxillin Interactions36	8.9	VEGFC, BMP1, RAPGEF1, PAK1, ITGB1, ITGB4
29	Bladder cancer20	8.8	RB1, BRAF, VEGFA, VEGFC, RAF1, CDKN1A
30	STAT3 Pathway36	8.7	BRAF, BMP1, RAF1, LIF, BCL2, BAX
31	Activation of PKA through GPCR36	8.7	BRAF, VEGFC, BMP1, RAP1A, RAF1, RAP1B
32	14-3-3 Induced Intracellular Signaling36	8.7	VEGFC, BMP1, RAF1, FLT1, FIGF, FGF2
33	Epithelial Adherens Junctions36	8.6	VEGFC, BMP1, RAP1A, RAP1B, RAPGEF1, CDH1
34	Rho Family GTPases36	8.5	VIM, VEGFC, BMP1, RAF1, LIF, PAK1
35	Toxoplasmosis20	8.4	PIK3CA, BCL2, BCL2L1, XIAP, ITGB1, IRAK1
36	Chagas disease (American trypanosomiasis)20	8.2	PIK3CA, IRAK1, IL1B, IL6, FASLG, FAS
37	Activation of PKC through GPCR36	8.1	VEGFC, BMP1, RAP1A, RAF1, RAP1B, FLT1
38	GSK3 Signaling36	8.1	VEGFC, BMP1, CDH3, CDH1, FLT1, FIGF
39	p70S6K Signaling36	7.9	VEGFC, BMP1, RAF1, FLT1, FIGF, FGF2
40	GPCR Pathway36	7.9	BRAF, VEGFC, BMP1, RAP1A, RAF1, RAP1B
41	Apoptotic Pathways in Synovial Fibroblasts36	7.7	VEGFC, BMP1, FLT1, FIGF, FGF2, MET
42	Pathways in cancer20	7.7	PIK3CA, NCOA4, RET, RB1, VEGFA, VEGFC
43	NFAT in Immune Response36	7.7	VEGFC, BMP1, FLT1, FIGF, FGF2, MET
44	DHA Signaling36	7.6	VEGFC, BMP1, BCL2, BCL2L1, BAX, FLT1
45	PAK Pathway36	7.5	VEGFC, BMP1, LIF, PAK1, BCL2, BAX
46	Cytokine-cytokine receptor interaction20	7.4	VEGFA, VEGFC, LIF, LEP, LEPR, FLT1
47	p53 Mediated Apoptosis36	7.1	VEGFC, BMP1, BCL2, BAX, ATM, FLT1
48	Tec Kinases Signaling36	7.1	VEGFC, BMP1, PAK1, BCL2, BAX, ITGB1
49	TGF-Beta Pathway36	7.0	VEGFC, BMP1, BCL2, BAX, CDH1, FLT1
50	Pancreatic Adenocarcinoma36	6.4	RB1, BRAF, VEGFC, BMP1, RAF1, BCL2

Compounds related to papillary thyroid carcinoma according to GeneDecks:

(show top 50)    (show all 381)

id	Compound	Score	Top Affiliating Genes
1	glycogen32 18	11.9	PIK3CA, VIM, LIF, LGALS3, LEPR, CDKN1B
2	methionine32	10.9	RET, VIM, LIF, LGALS1, LBR, MT-ND5
3	atp32	10.7	PIK3CA, RET, RB1, BRAF, RAN, LIF
4	phosphatidylserine32 9 9	12.6	SELE, VIM, LMNB1, BCL2, LGALS1, MSN
5	carbohydrates32	10.5	SELE, SELP, LGALS1, LGALS3, S100A6, CD44
6	fibrinogen32	10.4	SELE, SELP, LIF, LGALS3, LEP, CIB1
7	estradiol32 9 18 9	13.2	NCOA4, PCNA, RB1, VIM, VEGFC, RARB
8	epinephrine32 9 18 9	13.1	SELE, SELP, RAP1B, LEP, LBR, MMP2
9	bleomycin32 9 9	12.0	XRCC1, ATM, CD44, FGF2, CCL2, TP53
10	arginine32	10.0	PIK3CA, RET, BRAF, VDR, BMP1, RAP1A
11	dopamine32 9 18 9	12.9	PIK3CA, RET, SELE, LMOD1, RARB, RAF1
12	lovastatin32 42 9 9	12.9	RB1, RAF1, XIAP, CDKN1A, CDKN1B, CDKN2A
13	ceramide32	9.9	PIK3CA, RB1, RAF1, BCL2L1, LGALS1, XIAP
14	folate32	9.8	SELE, VIM, VDR, MUC1, XRCC1, XRCC3
15	c2ceramide32	9.7	BCL2L1, BAX, IL1B, MAPK8, CASP3, AKT1
16	batimastat32 42 9 9	12.7	CD36, MMP11, MMP14, MMP15, MMP16, MMP2
17	nocodazole32 42 9 9	12.7	VIM, RAP1A, RAF1, RAN, CDKN1A, CDH1
18	topotecan32 9 9	11.6	RAN, BCL2, BCL2L1, ATM, ERBB2, TP53
19	superoxide32 18	10.6	PIK3CA, RB1, RAP1A, RAN, LIF, LGALS1
20	agar32	9.5	PIK3CA, RET, RB1, VIM, BRAF, RAP1A
21	gnrh32	9.5	VIM, RAF1, LEP, LEPR, MKI67, FASLG
22	12-o-tetradecanoylphorbol 13-acetate32	9.5	RET, RB1, BRAF, RAP1A, RARB, RAF1
23	mifepristone32 42 9 9	12.4	LIF, BCL2L1, MUC1, BAX, LBR, MKI67
24	5-aza-2deoxycytidine32	9.4	PCNA, SERPINB5, VIM, RARB, S100A4, CDKN1A
25	glutamate32	9.3	PIK3CA, PCNA, VIM, BRAF, VDR, BMP1
26	n-(4-hydroxyphenyl)retinamide32	9.2	RB1, VIM, RARB, BCL2, BCL2L1, BAX
27	creatinine32	9.2	PCNA, SELE, SELP, VDR, LEP, MUC1
28	cysteine32	9.1	PCNA, SELP, VDR, LMNB1, LMOD1, RARB
29	norepinephrine32 9 18 9	12.0	SELE, SELP, LIF, LEP, LBR, S100A6
30	oxygen32 18	9.9	RB1, RAP1A, RAN, LIF, BCL2, BCL2L1
31	cholesterol32 9 18 9	11.9	PIK3CA, RB1, SELE, SELP, LIF, LEP
32	vitamin d32	8.9	VIM, VDR, RARB, LGALS3, LEPR, LBR
33	geldanamycin32 9 9	10.9	BRAF, VEGFA, RAF1, BCL2L1, CDKN1A, CDH1
34	matrigel32	8.9	PIK3CA, RB1, SELE, SERPINB5, VIM, BRAF
35	alanine32	8.7	RET, PCNA, SELE, BRAF, VDR, BMP1
36	testosterone32 9 18 9	11.7	PIK3CA, NCOA4, RET, PCNA, RB1, SELE
37	pge232	8.6	SELE, RAP1A, RAF1, LIF, CDH1, FN1
38	rosiglitazone32 9 18 9	11.6	PIK3CA, SELE, RARB, LEP, CDKN1A, CD36
39	carboplatin32 34 9 9	11.6	RB1, VEGFA, LIF, BCL2, XIAP, CD44
40	lactate32	8.4	PIK3CA, PCNA, SELE, SELP, VIM, LIF
41	thalidomide32 42 9 9	11.4	VEGFA, BCL2L1, XIAP, CD36, FGF2, IL1B
42	flavopiridol32 9 9	10.3	RB1, VEGFA, BCL2, BCL2L1, BAX, XIAP
43	thapsigargin32 42	9.3	PCNA, RAF1, BCL2, BCL2L1, S100A6, CD36
44	bortezomib32 9 9	10.2	VEGFA, BCL2, BCL2L1, BAX, XIAP, CDKN1A
45	gemcitabine32 34 9 9	11.0	PCNA, VEGFA, BCL2, BCL2L1, MUC1, BAX
46	methotrexate32 34 42 9 9	11.9	PCNA, RB1, SELE, VIM, LEP, MUC1
47	ang ii32	7.9	VEGFA, CD36, MAPK8, MAPK3, MAPK10, MAPK1
48	ciglitazone32	7.7	RARB, BCL2L1, BAX, CDKN1A, CDKN1B, MMP2
49	herbimycin a32 42	7.5	RET, SELE, RAF1, CD36, CDH1, ITGB1
50	actinomycin d32	4.3	PIK3CA, RB1, SELE, VIM, VEGFA, VDR

Cellular components related to papillary thyroid carcinoma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:005654	9.8	E2F1, TRIM27, TXN, ESR2, AKT1, CAMK2G
2	integral to plasma membrane	GO:005887	9.7	DDR2, PTPRC, PTPRJ, PTPRS, TEK, TNF
3	platelet alpha granule lumen	GO:031093	9.7	ACTN2, TIMP1, THBS1, TGFB1, HGF, EGF
4	membrane	GO:016020	9.7	HLA-DQB1, HLA-DRB1, TRIM27, CTNNB1, NT5E, NRG1
5	cell surface	GO:009986	9.6	PTPRJ, NTRK1, PLAU, PLAUR, PDGFA, PDGFB
6	cytosol	GO:005829	9.6	NNMT, HMOX1, AKT2, AKT1, AKAP9, HRAS
7	caveola	GO:005901	9.6	SLC2A1, TGFBR2, SRC, PTGS2, PTGIS, PTCH1
8	external side of plasma membrane	GO:009897	9.4	TNF, PTPRC, NRCAM, THBS1, TGFBR2, CXCL12
9	plasma membrane	GO:005886	8.8	SRC, CTGF, CTNNA1, CTNNB1, NT5E, NTRK1
10	cytoplasm	GO:005737	8.4	PTEN, PTGS2, DAPK1, CYP27B1, CTNNB1, NT5E
11	nucleus	GO:005634	7.6	TP63, TP53, TRIM33, TRAF6, TRH, PTEN
12	extracellular region	GO:005576	7.4	CSF2, SOD1, CXCL12, TFF3, TF, DPP4
13	extracellular space	GO:005615	6.4	PDGFC, CCL2, ANGPT1, ANGPT2, FASLG, FAP

Biological processes related to papillary thyroid carcinoma according to GeneDecks:

(show top 50)    (show all 81)

id	Name	GO ID	Score	Top Affiliating Genes
1	activation of MAPKK activity	GO:000186	11.1	RAF1, NTRK1, NRAS, CRK
2	protein autophosphorylation	GO:046777	10.6	PAK1, ATM, IRAK1, FLT1, MET, CAMK2G
3	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.4	BRAF, CD44, FGF2, IL1B, ANGPT1, MAPK3
4	negative regulation of neuron apoptotic process	GO:043524	10.3	BRAF, BCL2, BCL2L1, CITED1, BAX, HRAS
5	angiogenesis	GO:001525	10.2	PIK3CA, NAA15, VEGFA, VEGFC, MMP2, FN1
6	nerve growth factor receptor signaling pathway	GO:048011	10.2	PIK3CA, BRAF, RAP1A, RAF1, RAPGEF1, CDKN1B
7	positive regulation of anti-apoptosis	GO:045768	10.2	BCL2L1, CITED1, CDKN1A, IL6, IL6R, ANGPT1
8	positive regulation of MAPK cascade	GO:043410	10.2	LIF, LEP, CD36, ITGB1, FLT1, IL6
9	positive regulation of angiogenesis	GO:045766	10.2	VEGFA, MMP9, FLT1, FGF2, IL1B, ANGPT2
10	response to estrogen stimulus	GO:043627	10.2	BCL2, CITED1, FAS, ANGPT1, CCND1, GHRL
11	heart development	GO:007507	10.2	PCNA, RAF1, ATM, CASP3, ERBB3, ERBB2
12	phosphatidylinositol-mediated signaling	GO:048015	10.1	PIK3CA, PCNA, UBE2C, CDKN1B, MDM2, AKT1
13	positive regulation of cell division	GO:051781	10.0	VEGFA, VEGFC, FIGF, FGF2, MEN1, IL1B
14	fibroblast growth factor receptor signaling pathway	GO:008543	10.0	PIK3CA, BRAF, RAF1, CDKN1B, FGF2, MDM2
15	organ regeneration	GO:031100	10.0	LIF, CDKN1A, MKI67, ANGPT2, ANGPT1, CCNE1
16	cell proliferation	GO:008283	10.0	PCNA, RAF1, RAP1B, ZFP36L2, BCL2L1, CITED1
17	response to DNA damage stimulus	GO:006974	9.9	BCL2, BCL6, CIB1, BAX, XRCC3, XIAP
18	positive regulation of gene expression	GO:010628	9.9	BRAF, VEGFA, VDR, CITED1, CD44, MET
19	positive regulation of blood vessel endothelial cell migration	GO:043536	9.8	VEGFA, VEGFC, FGF2, ANGPT1, AKT1, PDGFB
20	positive regulation of cell migration	GO:030335	9.8	RET, VEGFA, ITGB1, MMP14, FLT1, APC
21	positive regulation of protein phosphorylation	GO:001934	9.6	VEGFA, IL1B, FAM129A, MAPK3, CCND1, HRAS
22	organ morphogenesis	GO:009887	9.6	BRAF, VEGFC, VDR, BCL2, FGF2, MAPK3
23	positive regulation of smooth muscle cell proliferation	GO:048661	9.5	FLT1, IL6, IL6R, HMOX1, TRAF6, TNF
24	signal transduction	GO:007165	9.5	RET, VEGFC, VDR, RAP1A, RARB, RAF1
25	positive regulation of apoptotic process	GO:043065	9.5	RARB, BCL6, BAX, ATM, ITGB1, MMP9
26	platelet degranulation	GO:002576	9.5	SELP, VEGFA, VEGFC, CD36, FN1, FIGF
27	Ras protein signal transduction	GO:007265	9.5	RB1, RAF1, CDKN1A, CDKN2A, FGF2, MAPK3
28	activation of MAPK activity	GO:000187	9.4	IRAK1, FGF2, MET, IL1B, MAPK3, MAPK10
29	neuron apoptotic process	GO:051402	9.4	RB1, BCL2, BAX, ATM, FAS, CASP3
30	cytokine-mediated signaling pathway	GO:019221	9.4	CD44, IL1B, IL6, IL6R, MAPK3, CCL2
31	response to lipopolysaccharide	GO:032496	9.4	SELE, SELP, CITED1, MMP9, IRAK1, FASLG
32	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.3	VDR, RARB, BCL6, LEP, CD36, CDKN1C
33	cell cycle arrest	GO:007050	9.3	RB1, ATM, CDKN1A, CDKN1B, CDKN2A, CDKN1C
34	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.2	PIK3CA, BRAF, VEGFA, RAF1, LIF, PAK1
35	negative regulation of cell growth	GO:030308	9.0	RB1, BCL2, BCL6, CDKN1A, CDKN1B, CDKN2A
36	epidermal growth factor receptor signaling pathway	GO:007173	9.0	PIK3CA, RAF1, CDKN1B, MDM2, MAPK3, MAPK1
37	positive regulation of MAP kinase activity	GO:043406	8.9	VEGFA, FLT1, ERBB2, TNF, PDGFA, PDGFB
38	negative regulation of cell proliferation	GO:008285	8.8	VDR, RARB, RAF1, LIF, BCL6, CIB1
39	response to drug	GO:042493	8.8	VEGFC, BCL2, LGALS1, XRCC1, CDKN1A, CDH1
40	negative regulation of transcription, DNA-dependent	GO:045892	8.8	RB1, VDR, BCL6, CITED1, CDKN1B, CDKN2A
41	MAPK cascade	GO:000165	8.7	RET, RAF1, PAK1, MEN1, IL1B, MAPK3
42	platelet activation	GO:030168	8.7	PIK3CA, SELP, VEGFA, VEGFC, RAP1A, RAF1
43	blood coagulation	GO:007596	8.7	PIK3CA, KIF23, SELP, VEGFA, VEGFC, RAP1A
44	positive regulation of transcription, DNA-dependent	GO:045893	8.7	NCOA4, RET, RB1, NAA15, RAN, PAX8
45	anti-apoptosis	GO:006916	8.6	PIK3CA, BRAF, BCL2, BCL2L1, MUC1, XIAP
46	apoptotic process	GO:006915	8.5	VIM, LMNB1, RAF1, PAK1, BCL2, BCL2L1
47	response to hypoxia	GO:001666	8.4	VEGFA, RAF1, PAK1, BCL2, LEP, XRCC1
48	positive regulation of cell proliferation	GO:008284	8.3	VEGFA, VEGFC, LIF, BCL2L1, LEP, CDKN1B
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.3	RB1, VEGFA, VDR, RARB, LIF, PAX8
50	negative regulation of apoptotic process	GO:043066	8.0	BRAF, VEGFA, RAF1, BCL2, BCL2L1, LEP

Molecular functions related to papillary thyroid carcinoma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet-derived growth factor receptor binding	GO:005161	10.7	TYMP, PDGFRB, PDGFC, PDGFB, PDGFA, PTPRJ
2	collagen binding	GO:005518	10.6	DPP4, PDGFB, PDGFA, SMAD4, DDR2, FN1
3	transmembrane receptor protein tyrosine kinase activity	GO:004714	10.5	EGFR, NTRK1, DDR2, TEK, TRIM27, ERBB2
4	transcription regulatory region DNA binding	GO:044212	10.0	SMAD4, PHB, HIF1A, AHR, STAT3, NKX2-1
5	protein kinase binding	GO:019901	9.8	TRAF6, TP53, PTEN, PTPRJ, PTPRC, PDPK1
6	ATP binding	GO:005524	9.8	SRC, DAPK1, DDR2, TEK, TPR, TP53
7	protein homodimerization activity	GO:042803	9.7	PDGFC, PDGFB, PDGFA, RPL7, NOS2, SMAD4
8	identical protein binding	GO:042802	9.4	SMAD4, TNF, TP63, TP53, ERBB2, EGFR
9	enzyme binding	GO:019899	9.1	HIF1A, EGFR, PLAUR, PPARG, TOP2A, THRB
10	protein heterodimerization activity	GO:046982	9.1	TP53, PDGFA, PDGFB, EGFR, HIF1A, AHR
11	growth factor activity	GO:008083	8.2	PDGFB, PDGFC, EGF, TYMP, TGFA, TGFB1
12	cytokine activity	GO:005125	7.9	TNF, SPP1, NRG1, EDN1, CSF2, GDF15
13	protein binding	GO:005515	7.8	COPS5, CTNNB1, CTNNA1, SRC, DAPK1, PTPRC