MCID: PPL020
MIFTS: 59

Papillary Thyroid Carcinoma malady

Endocrine diseases, Cancer diseases, Genetic diseases categories

Summaries for Papillary Thyroid Carcinoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Papillary thyroid cancer or papillary thyroid carcinoma is the most common type of thyroid cancer,... more...

MalaCards: Papillary Thyroid Carcinoma, also known as thyroid carcinoma, papillary, is related to papillary carcinoma and thyroiditis. An important gene associated with Papillary Thyroid Carcinoma is NCOA4 (nuclear receptor coactivator 4), and among its related pathways are Pathways in cancer and Thyroid cancer. The compounds tyrosine and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and lung.

Description from OMIM:46 188550

Aliases & Classifications for Papillary Thyroid Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 9diseasecard, 22GTR, 46OMIM, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

papillary thyroid carcinoma 8 42 10 60
thyroid carcinoma, papillary 9 22 46
thyroid papillary carcinoma 46 44
familial nonmedullary thyroid cancer, papillary 42
nonmedullary thyroid carcinoma, papillary 42
papillary carcinoma of the thyroid gland 8
papillary carcinoma of thyroid 8
papillary thyroid cancer 44


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Disease Ontology8 DOID:3969
NCIt39 C4035
SNOMED-CT56 4797003, 255029007
OMIM46 188550
MeSH34 C536915

Related Diseases for Papillary Thyroid Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Papillary Thyroid Carcinoma family:

Familial Papillary Thyroid Carcinoma

Diseases related to Papillary Thyroid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1papillary carcinoma32.4BRAF, NKX2-1, NCOA4, RET, LGALS3, TG
2thyroiditis32.4TG
3follicular thyroid carcinoma31.4BRAF, NKX2-1, RET, LGALS3, TG
4adenoma31.2BRAF, NKX2-1, RET, LGALS3, TG
5thyroid cancer31.0CCDC6, BRAF, NKX2-1, NCOA4, RET, LGALS3
6struma ovarii31.0TG, NKX2-1
7goiter31.0TG, LGALS3, RET, NKX2-1, BRAF
8parathyroid carcinoma31.0RET
9parathyroid adenoma30.9LGALS3, RET
10thyroid medullary carcinoma30.9BRAF, NKX2-1, RET, LGALS3, TG
11follicular adenoma30.8LGALS3
12nodular goiter30.6BRAF, RET, LGALS3, TG
13paraganglioma30.6TG, RET
14adenocarcinoma30.5BRAF, NKX2-1, LGALS3
15autoimmune thyroiditis30.3BRAF, RET, LGALS3, TG
16breast cancer30.1BRAF, NCOA4, LGALS3
17hypothyroidism30.1NKX2-1, TG
18lung cancer30.1NKX2-1
19papillary adenoma10.8
20cervicitis10.8
21cribriform carcinoma10.7
22tall cell variant papillary carcinoma10.6
23papillary squamous carcinoma10.6
24cervical cancer10.6
25squamous cell carcinoma10.5
26familial adenomatous polyposis10.5
27hyperparathyroidism10.5
28bone carcinoma10.5
29primary hyperparathyroidism10.5
30multinodular goiter10.5
31familial medullary thyroid carcinoma10.5
32breast papillary carcinoma10.5
33graves' disease10.5
34multicentric papillary thyroid carcinoma10.4
35thyroid lymphoma10.4
36laryngeal carcinoma10.4
37laryngitis10.4
38pheochromocytoma10.4
39histiocytosis10.4
40in situ carcinoma10.4
41langerhans-cell histiocytosis10.4
42pituitary adenoma10.4
43vascular cancer10.4
44lymphadenitis10.3
45papillary adenocarcinoma10.3
46retinoblastoma10.3
47familial papillary thyroid carcinoma with renal papillary neoplasia10.3
48thyroid hyalinizing trabecular adenoma10.3
49adenoid cystic carcinoma10.3
50adenoiditis10.3

Graphical network of the top 20 diseases related to Papillary Thyroid Carcinoma:



Diseases related to papillary thyroid carcinoma

Clinical Features for Papillary Thyroid Carcinoma

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46OMIM
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Clinical features from OMIM:

188550

Clinical synopsis from OMIM:

188550

Drugs & Therapeutics for Papillary Thyroid Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Papillary Thyroid Carcinoma

Drug clinical trials:

Search ClinicalTrials for Papillary Thyroid Carcinoma

Search NIH Clinical Center for Papillary Thyroid Carcinoma

Search CenterWatch for Papillary Thyroid Carcinoma

Genetic Tests for Papillary Thyroid Carcinoma

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22GTR
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Genetic tests related to Papillary Thyroid Carcinoma:

id Genetic test Affiliating Genes
1 Papillary Thyroid Carcinoma22

Anatomical Context for Papillary Thyroid Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Papillary Thyroid Carcinoma:

32
Thyroid, Lymph node, Lung, Endothelial, Bone, Pituitary, Breast, Ovary, Brain, Colon, Pancreas, Testes, Skin, Thymus, B cells, Kidney, Heart, Cervix, Salivary gland, Liver, Tongue, T cells, Monocytes, Bone marrow, Trachea, Nk cells

Animal Models for Papillary Thyroid Carcinoma or affiliated genes

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Publications for Papillary Thyroid Carcinoma

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50PubMed
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Articles related to Papillary Thyroid Carcinoma:

(show top 50)    (show all 1526)
idTitleAuthorsYear
1
Response to sorafenib in a pediatric patient with papillary thyroid carcinoma with diffuse nodular pulmonary disease requiring mechanical ventilation. (23544852)
2014
2
BRAF (V600E) mutation analysis in papillary thyroid carcinomas by peptide nucleic acid clamp real-time PCR. (23179992)
2013
3
The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis. (23211578)
2013
4
Serum antithyroglobulin antibodies interfere with thyroglobulin detection in fine-needle aspirates of metastatic neck nodes in papillary thyroid carcinoma. (23144473)
2013
5
Sonographic findings predictive of central lymph node metastasis in patients with papillary thyroid carcinoma: influence of associated chronic lymphocytic thyroiditis on the diagnostic performance of sonography. (24277897)
2013
6
B-flow twinkling sign in preoperative evaluation of cervical lymph nodes in patients with papillary thyroid carcinoma. (23878537)
2013
7
Papillary thyroid carcinoma and medicolegal considerations. (24008611)
2013
8
Clinical utility of immunohistochemistry for the detection of the BRAF v600e mutation in papillary thyroid carcinoma. (23931769)
2013
9
Comparative analysis of oncological outcomes and quality of life after robotic versus conventional open thyroidectomy with modified radical neck dissection in patients with papillary thyroid carcinoma and lateral neck node metastases. (23678034)
2013
10
Unusual association of primary hyperparathyroidism, papillary thyroid carcinoma, and follicular adenoma in a young female. (23776923)
2013
11
An Unusual Malignant Thyroid Nodule: Coexistence of Epithelioid Angiosarcoma and Follicular Variant Papillary Thyroid Carcinoma. (23608996)
2013
12
The tall cell variant of papillary thyroid carcinoma: clinical and pathological features and outcomes. (22776915)
2013
13
Can the tall cell variant of papillary thyroid carcinoma be distinguished from the conventional type in fine needle aspirates? A cytomorphologic study with assessment of diagnostic accuracy. (24021475)
2013
14
Expression of TGF-I^1, SNAI1 and MMP-9 is associated with lymph node metastasis in papillary thyroid carcinoma. (24276590)
2013
15
Multifocal papillary thyroid carcinoma-a consensus report of the European Society of Endocrine Surgeons (ESES). (24263684)
2013
16
A novel definition of extrathyroidal invasion for patients with papillary thyroid carcinoma for predicting prognosis. (22402972)
2012
17
The BRAF V600E mutation in papillary thyroid carcinoma is associated with glucose transporter 1 overexpression. (22376167)
2012
18
Neurofibromatosis type 1 associated with papillary thyroid carcinoma incidentally detected by thyroid ultrasonography: a case report. (22747746)
2012
19
True mixed medullary papillary carcinoma of the thyroid: a case report with low blood calcitonin levels. (22733476)
2012
20
Cribriform-morular variant of papillary thyroid carcinoma in an 8-year-old girl: a case report with immunohistochemical and molecular testing. (22494995)
2012
21
Synchronous papillary thyroid carcinoma and primary hyperparathyroidism: diagnosis and management issues. (23299031)
2012
22
Cerebellar metastatic papillary thyroid carcinoma in a pediatric patient with complex congenital heart disease. (23329771)
2012
23
Utilization of a MAB for BRAF(V600E) detection in papillary thyroid carcinoma. (22997209)
2012
24
Coexistence of chronic lymphocytic thyroiditis with papillary thyroid carcinoma: clinical manifestation and prognostic outcome. (22876054)
2012
25
American Thyroid Association (ATA) - Design and Feasibility of a Prospective Randomized Controlled Trial of Prophylactic Central Lymph Node Dissection for Papillary Thyroid Carcinoma. (22150591)
2011
26
Somatostatin receptor 2 expression determined by immunohistochemistry in cold thyroid nodules exceeds that of hot thyroid nodules, papillary thyroid carcinoma, and Graves' disease. (20450431)
2010
27
First description of papillary carcinoma in the thyroid gland of a red-eared slider (Trachemys scripta elegans ). (20159740)
2010
28
Phosphorylated c-Jun NH2-terminal kinase is overexpressed in human papillary thyroid carcinomas and associates with lymph node metastasis. (20138424)
2010
29
RET rearrangements and BRAF mutation in undifferentiated thyroid carcinomas having papillary carcinoma components. (20840674)
2010
30
Clinicopathologic significance of leptin and leptin receptor expressions in papillary thyroid carcinoma. (20045163)
2010
31
Immunohistochemical demonstration of membrane-bound prostaglandin E2 synthase-1 in papillary thyroid carcinoma. (19759871)
2009
32
Correspondence between ultrasonography and histological features in a single thyroid nodule with coexisting follicular adenoma and papillary carcinoma. (18631017)
2008
33
A solitary metastatic lung tumor from thyroid papillary carcinoma diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): report of a case. (18085362)
2008
34
Immunohistochemical expression of pl30cas in papillary thyroid carcinoma. (18828274)
2008
35
Papillary thyroid carcinoma with lymph node metastases. (17454149)
2007
36
A multi-gene approach to differentiate papillary thyroid carcinoma from benign lesions: gene selection using support vector machines with bootstrapping. (17914110)
2007
37
Presence of BRAF V600E in very early stages of papillary thyroid carcinoma. (17542667)
2007
38
Fasciitislike papillary Carcinoma of the thyroid gland. (16124181)
2005
39
Metastatic melanoma of the thyroid mimicking a papillary carcinoma in fine-needle aspiration. (15880714)
2005
40
RET gene rearrangements (RET/PTC1 and RET/PTC3) in papillary thyroid carcinomas from an iodine-rich country (Japan). (16015630)
2005
41
Glutathione S-transferase and O6-methylguanine DNA methyl transferase activities in patients with thyroid papillary carcinoma. (12449729)
2002
42
Translocation t(10;14)(q11.2:q22.1) fusing the kinetin to the RET gene creates a novel rearranged form (PTC8) of the RET proto-oncogene in radiation-induced childhood papillary thyroid carcinoma. (10850414)
2000
43
Prognostic significance of RET and NTRK1 rearrangements in sporadic papillary thyroid carcinoma. (11114633)
2000
44
Expression of heregulins and associations with the ErbB family of tyrosine kinase receptors in papillary thyroid carcinomas. (10956383)
2000
45
Expression of inducible nitric oxide synthase in human thyroid papillary carcinomas. (10090309)
1999
46
Expression of transforming growth factor-beta1 and transforming growth factor-beta Type-II receptor mRNA in papillary thyroid carcinoma. (9851670)
1998
47
Low frequency of rearrangements of the ret and trk proto-oncogenes in Japanese thyroid papillary carcinomas. (1381340)
1992
48
Detection of RET oncogene activation in human papillary thyroid carcinomas by in situ hybridisation. (1457350)
1992
49
PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. (2406025)
1990
50
Expression of keratin 19 distinguishes papillary thyroid carcinoma from follicular carcinomas and follicular thyroid adenoma. (2479256)
1989

Genetic Variations for Papillary Thyroid Carcinoma

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Expression for genes affiliated with Papillary Thyroid Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papillary Thyroid Carcinoma

Search GEO for disease gene expression data for Papillary Thyroid Carcinoma.

Pathways for genes affiliated with Papillary Thyroid Carcinoma

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29KEGG
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Pathways related to Papillary Thyroid Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9RET, NCOA4, BRAF, CCDC6
210.9RET, NCOA4, BRAF, CCDC6

Compounds for genes affiliated with Papillary Thyroid Carcinoma

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44Novoseek, 24HMDB
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Compounds related to Papillary Thyroid Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tyrosine4411.5CCDC6, BRAF, NKX2-1, NCOA4, PCM1, RET
2retinoic acid44 2412.1TG, LGALS3, RET, TRIM24, NKX2-1, BRAF
3sodium iodide4411.0TG, RET, NKX2-1, BRAF
4paraffin4411.0BRAF, NKX2-1, RET, LGALS3, TG
5iodide44 2411.9TG, NKX2-1, BRAF
6estrogen4410.8BRAF, NKX2-1, NCOA4, TRIM24, LGALS3, TG
7agar4410.8TG, LGALS3, RET, BRAF

GO Terms for genes affiliated with Papillary Thyroid Carcinoma

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16Gene Ontology
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Biological processes related to Papillary Thyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:03087810.7TG, NKX2-1

Products for genes affiliated with Papillary Thyroid Carcinoma

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Sources for Papillary Thyroid Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet