MCID: PPL020
MIFTS: 59

Papillary Thyroid Carcinoma malady

Genetic diseases, Rare diseases, Cancer diseases, Endocrine diseases categories
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Summaries for Papillary Thyroid Carcinoma

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Disease Ontology:8 A thyroid carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer.

MalaCards based summary: Papillary Thyroid Carcinoma, also known as thyroid carcinoma, papillary, is related to goiter and papillary carcinoma, and has symptoms including An important gene associated with Papillary Thyroid Carcinoma is NCOA4 (nuclear receptor coactivator 4), and among its related pathways are Pathways in cancer and Thyroid cancer. The compounds sodium iodide and agar have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and endothelial, and related mouse phenotype digestive/alimentary.

Wikipedia:65 Papillary thyroid cancer or papillary thyroid carcinoma is the most common type of thyroid cancer,... more...

Description from OMIM:46 188550

Aliases & Classifications for Papillary Thyroid Carcinoma

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Papillary Thyroid Carcinoma, Aliases & Descriptions:

Name: Papillary Thyroid Carcinoma 8 42 10 62
Thyroid Carcinoma, Papillary 9 22 46
Papillary Carcinoma of the Thyroid Gland 8 62
Thyroid Papillary Carcinoma 46 44
 
Familial Nonmedullary Thyroid Cancer, Papillary 42
Nonmedullary Thyroid Carcinoma, Papillary 42
Papillary Thyroid Cancer 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:3969
OMIM46 188550
SNOMED-CT57 255029007, 4797003
NCIt39 C4035
MeSH34 C536915

Related Diseases for Papillary Thyroid Carcinoma

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Diseases in the Papillary Thyroid Carcinoma family:

Familial Papillary Thyroid Carcinoma

Diseases related to Papillary Thyroid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.7BRAF, RET, LGALS3
2papillary carcinoma31.5NCOA4, LGALS3, RET, BRAF
3parathyroid adenoma31.4LGALS3, RET
4follicular adenoma31.4LGALS3
5nodular goiter31.4BRAF, RET, LGALS3
6follicular thyroid carcinoma31.4BRAF, RET, LGALS3
7thyroid adenoma31.3BRAF, RET, LGALS3
8hypothyroidism30.9BRAF, RET, LGALS3, FOXE1
9autoimmune thyroiditis30.8LGALS3, RET, BRAF
10thyroiditis11.7
11adenoma10.8
12cervicitis10.8
13struma ovarii10.8
14familial papillary thyroid carcinoma10.7
15endotheliitis10.7
16familial adenomatous polyposis10.6
17hyperparathyroidism10.6
18multiple endocrine neoplasia10.6
19multinodular goiter10.5
20graves' disease10.5
21primary hyperparathyroidism10.5
22laryngitis10.5
23thyroid cancer10.5
24pheochromocytoma10.5
25multicentric papillary thyroid carcinoma10.5
26langerhans-cell histiocytosis10.5
27paraganglioma10.5
28histiocytosis10.5
29pituitary adenoma10.5
30multiple endocrine neoplasia type 2a10.5
31thyroid cancer, anaplastic10.4BRAF, RET, LGALS3
32thyroid hurthle cell carcinoma10.4BRAF, RET, LGALS3, CCDC6, NCOA4
33pilocytic astrocytoma10.4LGALS3
34thyroid medullary carcinoma10.4BRAF, RET, LGALS3
35adenocarcinoma10.4
36lymphadenitis10.4
37retinoblastoma10.4
38teratoma10.4
39familial papillary thyroid carcinoma with renal papillary neoplasia10.4
40thyroid agenesis10.4LGALS3, FOXE1
41adenoiditis10.4
42leiomyosarcoma10.4
43ataxia telangiectasia10.3
44parathyroid carcinoma10.3
45familial medullary thyroid carcinoma10.3
46choroiditis10.3
47laryngeal squamous cell carcinoma10.3
48meningioma10.3
49ataxia10.3
50hypoxia10.3

Graphical network of the top 20 diseases related to Papillary Thyroid Carcinoma:



Diseases related to papillary thyroid carcinoma

Symptoms for Papillary Thyroid Carcinoma

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Symptoms by clinical synopsis from OMIM:

188550

Clinical features from OMIM:

188550

HPO human phenotypes related to Papillary Thyroid Carcinoma:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 papillary thyroid carcinoma HP:0002895

Drugs & Therapeutics for Papillary Thyroid Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Papillary Thyroid Carcinoma

Search NIH Clinical Center for Papillary Thyroid Carcinoma

Genetic Tests for Papillary Thyroid Carcinoma

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Genetic tests related to Papillary Thyroid Carcinoma:

id Genetic test Affiliating Genes
1 Papillary Thyroid Carcinoma22

Anatomical Context for Papillary Thyroid Carcinoma

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MalaCards organs/tissues related to Papillary Thyroid Carcinoma:

32
Thyroid, Lymph node, Endothelial, Lung, Pituitary, Bone, Breast, Colon, Brain, Kidney, Ovary, Testes, B cells, Heart, Liver, Pancreas, Skin, Monocytes, T cells, Trachea

Animal Models for Papillary Thyroid Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Papillary Thyroid Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.1TRIM33, FOXE1, LGALS3, RET, BRAF

Publications for Papillary Thyroid Carcinoma

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Articles related to Papillary Thyroid Carcinoma:

(show top 50)    (show all 1095)
idTitleAuthorsYear
1
Expression and clinical significance of STIP1 in papillary thyroid carcinoma. (24163084)
2013
2
Tumor size measured by preoperative ultrasonography and postoperative pathologic examination in papillary thyroid carcinoma: relative differences according to size, calcification and coexisting thyroiditis. (23880922)
2013
3
Establishing a familial basis for papillary thyroid carcinoma using the Utah Population Database. (24092278)
2013
4
Follicular variant of papillary thyroid carcinoma is a unique clinical entity: a population-based study of 10,740 cases. (23477346)
2013
5
Extranodal extension of metastatic papillary thyroid carcinoma: correlation with biochemical endpoints, nodal persistence, and systemic disease progression. (23421588)
2013
6
Tall Cell Variant Papillary Thyroid Carcinoma Arising from Struma Ovarii. (24246339)
2013
7
A rare coexistence of thyroid lymphoma with papillary thyroid carcinoma. (24005594)
2013
8
Surgical complications and recurrence after central neck dissection in cN0 papillary thyroid carcinoma. (23886706)
2013
9
Candidates for Limited Lateral Neck Dissection among Patients with Metastatic Papillary Thyroid Carcinoma. (24337241)
2013
10
Predictive factors for different subgroups of central lymph node metastasis in unilateral papillary thyroid carcinoma. (24107609)
2013
11
Cutaneous metastasis of papillary thyroid carcinoma to the thyroidectomy scar. (23676148)
2013
12
Comparative serum proteomic analysis identified afamin as a downregulated protein in papillary thyroid carcinoma patients with non-131I-avid lung metastases. (24089082)
2013
13
Metastatic papillary thyroid carcinoma to the kidney: report of two cases mimicking primary renal cell carcinoma and review of the literature. (23255036)
2013
14
Cribriform morular variant of papillary thyroid carcinoma: clinical and cytomorphological features on fine-needle aspiration. (23406819)
2013
15
Lymph node metastasis between sternocleidomastoid and sternohyoid muscle in clinically node-positive papillary thyroid carcinoma. (22927223)
2013
16
Papillary thyroid carcinoma associated to squamous cell carcinoma. (24332292)
2013
17
Unusual muscular metastases from papillary thyroid carcinoma detected by fluorine-18-fluorodeoxyglucose PET/MRI. (23596135)
2013
18
Papillary thyroid carcinoma-like tumor of the kidney: a case report. (22158951)
2012
19
Role of Caspase 8, Caspase 9 and Bcl-2 polymorphisms in papillary thyroid carcinoma risk in Han Chinese population. (22120515)
2012
20
Focal bronchiectasis causing abnormal pulmonary radioiodine uptake in a patient with well-differentiated papillary thyroid carcinoma. (23097725)
2012
21
Basal STAT3 activities are negatively correlated with tumor size in papillary thyroid carcinomas. (21897114)
2012
22
Tuberculous cervical lymphadenitis masquerding as metastatis from papillary thyroid carcinoma. (23843822)
2012
23
BRAF mutation in papillary thyroid carcinoma. (22993650)
2012
24
A novel definition of extrathyroidal invasion for patients with papillary thyroid carcinoma for predicting prognosis. (22402972)
2012
25
Soluble human leukocyte antigen-g and its insertion/deletion polymorphism in papillary thyroid carcinoma: novel potential biomarkers of disease? (22930786)
2012
26
Coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma: the influence of lymph node metastasis. (21837696)
2011
27
The preeminence of growth pattern and invasiveness and the limited influence of BRAF and RAS mutations in the occurrence of papillary thyroid carcinoma lymph node metastases. (21796448)
2011
28
BRAF(V600E) mutation analysis from May-GrA1nwald Giemsa-stained cytological samples as an adjunct in identification of high-risk papillary thyroid carcinoma. (21948220)
2011
29
Somatostatin receptor 2 expression determined by immunohistochemistry in cold thyroid nodules exceeds that of hot thyroid nodules, papillary thyroid carcinoma, and Graves' disease. (20450431)
2010
30
Rearrangements of NTRK1 gene in papillary thyroid carcinoma. (19883730)
2010
31
Usefulness of the determination of thyroglobulin in lymph node aspirates of patients with papillary thyroid carcinoma and positive antithyroglobulin antibodies]. (20096208)
2009
32
Lack of GNAQ hotspot mutation in papillary thyroid carcinomas. (19445628)
2009
33
RET/PTC rearrangements arising from a small population of papillary thyroid carcinoma cells, possible candidate for passenger mutation. (19495791)
2009
34
BRAF mutation in solid cell nest hyperplasia associated with papillary thyroid carcinoma. A precursor lesion? (19269016)
2009
35
Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation. (19958951)
2009
36
BRAFV600E mutation and X-linked inhibitor of apoptosis expression in papillary thyroid carcinoma. (19355825)
2009
37
Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism. (19491068)
2009
38
Association of genetic polymorphisms and haplotypes in hMLH1 and hMSH3 gene with the risk of papillary thyroid carcinoma]. (18683134)
2008
39
A papillary thyroid carcinoma case associated with hereditary colon carcinoma due to familial adenomatous polyposis with no hereditary mutation finding. (15834731)
2007
40
The oncogene BRAF V600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I- targeting to the membrane. (16601293)
2006
41
Gene expression in poorly differentiated papillary thyroid carcinomas. (16676402)
2006
42
Increased expression of vascular endothelial growth factor C in papillary thyroid carcinoma correlates with cervical lymph node metastases. (16299237)
2005
43
Ret/PTC activation does not influence clinical and pathological features of adult papillary thyroid carcinomas. (12720532)
2003
44
Breast tumor resembling the tall cell variant of papillary thyroid carcinoma: report of 5 cases. (12883243)
2003
45
Nuclear envelope organization in papillary thyroid carcinoma. (11193183)
2001
46
High prevalence of RET tyrosine kinase activation in Mexican patients with papillary thyroid carcinomas. (11579677)
2001
47
Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma. (10697956)
2000
48
Oncogene profile of papillary thyroid carcinoma. (9889797)
1999
49
Papillary thyroid carcinoma, parathyroid adenoma, and unexplained hypercalcitoninemia: an unusual presentation of multiple endocrine neoplasia type 2A? (9777749)
1998
50
Antitumor actions of cytokines on new human papillary thyroid carcinoma cell lines. (8675585)
1996

Variations for Papillary Thyroid Carcinoma

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Clinvar genetic disease variations for Papillary Thyroid Carcinoma:

6
id Gene Name Type Significance SNP ID Assembly Location
1BRAFNM_004333.4(BRAF): c.1799T> A (p.Val600Glu)single nucleotide variantPathogenicrs113488022GRCh37Chr 7, 140453136: 140453136

Expression for genes affiliated with Papillary Thyroid Carcinoma

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Expression patterns in normal tissues for genes affiliated with Papillary Thyroid Carcinoma

Search GEO for disease gene expression data for Papillary Thyroid Carcinoma.

Pathways for genes affiliated with Papillary Thyroid Carcinoma

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Pathways related to Papillary Thyroid Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2NCOA4, CCDC6, RET, BRAF
210.2NCOA4, CCDC6, RET, BRAF

Compounds for genes affiliated with Papillary Thyroid Carcinoma

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Papillary Thyroid Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sodium iodide4410.3BRAF, RET
2agar4410.2LGALS3, RET, BRAF
3regorafenib50 1111.2RET, BRAF
4tyrosine4410.0NCOA4, PCM1, CCDC6, LGALS3, RET, BRAF
5iodide44 2411.0FOXE1, BRAF

GO Terms for genes affiliated with Papillary Thyroid Carcinoma

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Biological processes related to Papillary Thyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription, DNA-templatedGO:04589310.2TRIM24, NCOA4, FOXE1, RET

Products for genes affiliated with Papillary Thyroid Carcinoma

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Sources for Papillary Thyroid Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet