MCID: PPL020
MIFTS: 49

Papillary Thyroid Carcinoma malady

Summaries for Papillary Thyroid Carcinoma

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Papillary thyroid cancer or papillary thyroid carcinoma is the most common type of thyroid cancer,... more...

MalaCards: Papillary Thyroid Carcinoma, also known as thyroid carcinoma, papillary, is related to papillary carcinoma and thyroiditis. An important gene associated with Papillary Thyroid Carcinoma is NCOA4 (nuclear receptor coactivator 4), and among its related pathways are Pathways in cancer and Thyroid cancer. The compounds tyrosine and retinoic acid have been mentioned in the context of this disorder.

Description from OMIM:47 188550

Aliases & Classifications for Papillary Thyroid Carcinoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 9diseasecard, 22GTR, 47OMIM, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

papillary thyroid carcinoma 8 10 61
thyroid carcinoma, papillary 9 22 47
thyroid papillary carcinoma 47 45
papillary carcinoma of the thyroid gland 8
papillary carcinoma of thyroid 8
papillary thyroid cancer 45


External Ids:

Disease Ontology8 DOID:3969
NCIt40 C4035
SNOMED-CT57 4797003, 255029007
OMIM47 188550
MeSH35 C536915

Related Diseases for Papillary Thyroid Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Papillary Thyroid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1papillary carcinoma32.5TG, BRAF, NCOA4, RET, LGALS3, NKX2-1
2thyroiditis31.3TG
3thyroid adenoma31.3RET, TG, BRAF, LGALS3
4adenoma31.3NKX2-1, RET, BRAF, LGALS3, TG
5thyroid cancer31.1TG, LGALS3, RET, BRAF, CCDC6, NKX2-1
6struma ovarii31.1NKX2-1, TG
7parathyroid carcinoma31.0RET
8thyroid medullary carcinoma31.0RET, BRAF, TG, LGALS3, NKX2-1
9nodular goiter30.6LGALS3, BRAF, RET, TG
10paraganglioma30.6RET, TG
11teratoma30.5TG, NKX2-1
12adenocarcinoma30.5BRAF, NKX2-1, LGALS3
13thyroid cancer, anaplastic30.2RET, TG, NKX2-1, BRAF, LGALS3
14autoimmune thyroiditis30.2TG, LGALS3, RET, BRAF
15thyroid agenesis30.2NKX2-1, TG, LGALS3
16papillary adenoma10.9
17familial papillary thyroid carcinoma10.8
18cribriform carcinoma10.7
19tall cell variant papillary carcinoma10.6
20papillary squamous carcinoma10.6
21squamous cell carcinoma10.6
22familial adenomatous polyposis10.5
23multiple endocrine neoplasia10.5
24bone carcinoma10.5
25primary hyperparathyroidism10.5
26multinodular goiter10.5
27breast papillary carcinoma10.5
28graves' disease10.5
29multicentric papillary thyroid carcinoma10.5
30thyroid lymphoma10.5
31pheochromocytoma10.5
32vascular cancer10.4
33familial medullary thyroid carcinoma10.4
34trachea carcinoma10.4
35papillary renal carcinoma10.4
36thyroid carcinoma, papillary, somatic10.4
37familial papillary thyroid carcinoma with renal papillary neoplasia10.4
38thyroid hyalinizing trabecular adenoma10.3
39adenoid cystic carcinoma10.3
40thyroid cancer, childhood10.3
41nontoxic goiter10.3
42columnar cell variant papillary carcinoma10.3
43lung papillary adenocarcinoma10.3
44ovary papillary carcinoma10.3
45n syndrome10.3
46warthin tumor10.3
47hypoxia10.3
48thyroid carcinoma, papillary, with papillary renal neoplasia10.3
49adult t-cell leukemia10.2
50adult lymphoma10.2

Graphical network of the top 20 diseases related to Papillary Thyroid Carcinoma:



Diseases related to papillary thyroid carcinoma

Clinical Features for Papillary Thyroid Carcinoma

Sources:
47OMIM
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Clinical features from OMIM:

188550

Clinical synopsis from OMIM:

188550

Drugs & Therapeutics for Papillary Thyroid Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Papillary Thyroid Carcinoma

Drug clinical trials:

Search ClinicalTrials for Papillary Thyroid Carcinoma

Search NIH Clinical Center for Papillary Thyroid Carcinoma

Search CenterWatch for Papillary Thyroid Carcinoma

Genetic Tests for Papillary Thyroid Carcinoma

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22GTR
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Genetic tests related to Papillary Thyroid Carcinoma:

id Genetic test Affiliating Genes
1 Papillary Thyroid Carcinoma22

Anatomical Context for Papillary Thyroid Carcinoma

Animal Models for Papillary Thyroid Carcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Papillary Thyroid Carcinoma

Sources:
51PubMed
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Articles related to Papillary Thyroid Carcinoma:

(show top 50)    (show all 1533)
idTitleAuthorsYear
1
Pleural metastases from papillary thyroid carcinoma mimicking mesothelioma. (24429460)
2014
2
Remarkable response to radioiodine therapy in a case of metastatic macrofollicular variant of papillary thyroid carcinoma. (24368535)
2014
3
Expression and clinical significance of STIP1 in papillary thyroid carcinoma. (24163084)
2013
4
Femoral pathological fracture as the first clinical manifestation of papillary thyroid carcinoma in a primigravida. (23691401)
2013
5
BRAF mutation status in papillary thyroid carcinoma: significance for surgical strategy. (24375266)
2013
6
Selective sentinel lymph node biopsy in papillary thyroid carcinoma. (23415778)
2013
7
The usefulness and accuracy of sentinel lymph node biopsy using single photon emission computed tomography/computed tomography with 99mTc phytate to detect locoregional lymph node metastases in patients with papillary thyroid carcinoma. (23577313)
2013
8
Nodal status of central lymph nodes as a negative prognostic factor for papillary thyroid carcinoma. (23640873)
2013
9
FNA diagnosis of a metastatic papillary thyroid carcinoma arising from a previously unknown follicular variant of papillary thyroid microcarcinoma. (23913830)
2013
10
Cribriform-morular variant of papillary thyroid carcinoma displaying poorly differentiated features. (23349472)
2013
11
Activation of nuclear factor-I_B contributes to growth and aggressiveness of papillary thyroid carcinoma. (23528368)
2013
12
BRAF mutation in papillary thyroid carcinoma: Predictive value for long-term prognosis and radioiodine sensitivity. (23845288)
2013
13
Giant papillary carcinoma arising in the ectopic buccal thyroid tissue. (22965924)
2013
14
Long-term results of surgery for papillary thyroid carcinoma with local recurrence. (23052744)
2013
15
Role of Caspase 8, Caspase 9 and Bcl-2 polymorphisms in papillary thyroid carcinoma risk in Han Chinese population. (22120515)
2012
16
New molecular targeted therapy and redifferentiation therapy for radioiodine-refractory advanced papillary thyroid carcinoma: literature review. (23320248)
2012
17
Papillary thyroid carcinomas with and without BRAF V600E mutations are morphologically distinct. (22335197)
2012
18
Current trends in TSH suppression therapy for patients with papillary thyroid carcinoma in Japan: results of a questionnaire distributed to councilors of the Japanese Society of Thyroid Surgery. (22173648)
2012
19
Silencing of homeobox B9 is associated with down-regulation of CD56 and extrathyroidal extension of tumor in papillary thyroid carcinoma. (22225776)
2012
20
Diffuse sclerosing variant of papillary thyroid carcinoma with multiple metastases and elevated serum carcinoembryonic antigen level. (23050785)
2012
21
Age and prognosis of papillary thyroid carcinoma: retrospective stratification into three groups. (23166884)
2012
22
BRAFV600E mutation does not mean distant metastasis in thyroid papillary carcinomas. (22740704)
2012
23
Phase II efficacy and pharmacogenomic study of Selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinoma with or without follicular elements. (22241789)
2012
24
Surgical treatment of papillary thyroid carcinoma without lymph nodal involvement. (23095564)
2012
25
Density of Tumor Associated Macrophage Correlates with Lymph Node Metastasis in Papillary Thyroid Carcinoma. (22594885)
2012
26
Sensitivity of fine-needle aspiration for papillary carcinoma of the thyroid correlates with tumor size. (21695800)
2011
27
BRAF gene mutation in the natural history of papillary thyroid carcinoma: diagnostic and prognostic implications]. (22863493)
2011
28
Coexistence of parathyroid adenoma and papillary thyroid carcinoma. (22148123)
2011
29
Detectable BRAF mutation in serum DNA samples from patients with papillary thyroid carcinomas. (19626635)
2010
30
Composite follicular variant of papillary carcinoma and mucoepidermoid carcinoma of thyroid gland: a case report. (21060764)
2010
31
A susceptibility locus for papillary thyroid carcinoma on chromosome 8q24. (19147577)
2009
32
Correlation between thyroid-stimulating hormone-peroxiredoxin1 signaling pathway and invasion of papillary thyroid carcinoma]. (19558833)
2009
33
Mutation analysis of RAP1 gene in papillary thyroid carcinomas. (18948674)
2009
34
Molecular analysis of multifocal papillary thyroid carcinoma. (18628356)
2008
35
The potential clinical relevance of serum vascular endothelial growth factor (VEGF) and VEGF-C in recurrent papillary thyroid carcinoma. (19041000)
2008
36
Differential expression of dysadherin in papillary thyroid carcinoma and microcarcinoma: correlation with E-cadherin. (18677652)
2008
37
Elective paratracheal neck dissection for lateral metastases from papillary carcinoma of the thyroid: is it indicated? (17615566)
2008
38
Solid/trabecular variant papillary carcinoma of the thyroid: Report of three cases with fine-needle aspiration. (16955471)
2006
39
Simulated weightlessness changes the cytoskeleton and extracellular matrix proteins in papillary thyroid carcinoma cells. (16432709)
2006
40
Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations. (15880523)
2005
41
RET/PTC and CK19 expression in papillary thyroid carcinoma and its clinicopathologic correlation. (15716612)
2005
42
Morphologic spectrum of papillary carcinoma of the thyroid: role of cytology in identifying the variants. (15581164)
2004
43
Lymph node dissection in papillary or follicular thyroid carcinoma. (15330196)
2004
44
Immunohistochemical detection of E-cadherin, alpha- and beta-catenins in papillary thyroid carcinoma. (12150330)
2002
45
Role of galectin-3 immunodetection in the cytological diagnosis of thyroid cystic papillary carcinoma. (12370115)
2002
46
Study of immunohistochemical expression of insulin-like growth factor I and proliferating cell nuclear antigen in thyroid gland papillary carcinoma and its metastasis. (10562685)
1999
47
MAGE-1, GAGE-1/-2 gene expression in FNAB of classic variant of papillary thyroid carcinoma and papillary hyperplasia in nodular goiter. (10493989)
1999
48
Hyperfunctioning thyroid adenoma concomitant with papillary thyroid carcinoma, follicular thyroid adenoma and primary hyperparathyroidism. (9625447)
1998
49
Multiple primary malignant tumours: gemistocytic astrocytoma with leptomeningeal spreading and papillary thyroid carcinoma. A case report. (2251958)
1990
50
Is the differentiation between papillary and follicular thyroid carcinoma valid? (4751916)
1973

Genetic Variations for Papillary Thyroid Carcinoma

Expression for genes affiliated with Papillary Thyroid Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papillary Thyroid Carcinoma

Search GEO for disease gene expression data for Papillary Thyroid Carcinoma.

Pathways for genes affiliated with Papillary Thyroid Carcinoma

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30KEGG
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Pathways related to Papillary Thyroid Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9RET, NCOA4, BRAF, CCDC6
210.9RET, NCOA4, BRAF, CCDC6

Compounds for genes affiliated with Papillary Thyroid Carcinoma

Sources:
45Novoseek, 24HMDB
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Compounds related to Papillary Thyroid Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tyrosine4511.5LGALS3, RET, PCM1, NCOA4, NKX2-1, BRAF
2retinoic acid45 2412.1LGALS3, RET, TRIM24, NKX2-1, BRAF, TG
3sodium iodide4511.0BRAF, NKX2-1, RET, TG
4paraffin4511.0TG, LGALS3, RET, NKX2-1, BRAF
5iodide45 2411.9BRAF, NKX2-1, TG
6estrogen4510.8BRAF, NCOA4, TG, LGALS3, TRIM24, NKX2-1
7agar4510.8TG, LGALS3, RET, BRAF

GO Terms for genes affiliated with Papillary Thyroid Carcinoma

Sources:
16Gene Ontology
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Biological processes related to Papillary Thyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:03087810.7TG, NKX2-1

Products for genes affiliated with Papillary Thyroid Carcinoma

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Sources for Papillary Thyroid Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet