Papilledema disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PPL021 MIFTS: 50	Papilledema Categories: Rare diseases, Eye diseases, Neuronal diseases
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Aliases & Classifications for Papilledema

MalaCards integrated aliases for Papilledema:

Name: Papilledema ¹² ⁷² ⁴⁹ ²⁸ ⁵¹ ¹⁴ ⁶⁹

Edema of the Optic Disc ⁴⁹

Choked Disk ⁴⁹

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the eye and adnexa

Disorders of optic nerve and visual pathways

Other disorders of optic [2nd] nerve and visual pathways

Papilloedema, unspecified

External Ids:

Disease Ontology ¹² DOID:146

ICD10 ³² H46.0 H47.1 H47.10

ICD9CM ³⁴ 377.0 377.00 377.31

MeSH ⁴¹ D010211

NCIt ⁴⁶ C3307

SNOMED-CT ⁶⁴ 111526001 155187009 194038006 more

UMLS ⁶⁹ C0030353

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Summaries for Papilledema

NIH Rare Diseases : ⁴⁹ Papilledema is a condition in which increased pressure in or around the brain (intracranial pressure) causes swelling of the part of the optic nerve inside the eye (optic disc). Symptoms of increased intracranial pressure include headache or nausea and vomiting. Vision problems are not common initially, but may include short flickers of gray vision, blurred or double vision, and decreased field of vision or ability to see colors. Both eyes are usually affected. Papilledema by definition is caused by increased cranial pressure. Diagnosis includes a thorough eye exam by an ophthalmologist. Brain imaging studies (for example CT scan or MRI) are used to find the cause of the increased intracranial pressure. Treatment depends on the cause of the increased pressure but may include medications, surgery and/or weight management. Last updated: 8/31/2016

MalaCards based summary : Papilledema, also known as edema of the optic disc, is related to intracranial hypertension and intracranial hypertension, idiopathic, and has symptoms including edema An important gene associated with Papilledema is TP53 (Tumor Protein P53), and among its related pathways/superpathways is IL1 and megakaryocytes in obesity. The drugs Acetazolamide and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and ovary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : ⁷² Papilledema (or papilloedema) is optic disc swelling that is caused by increased intracranial pressure.... more...

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Related Diseases for Papilledema

Diseases related to Papilledema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)

#	Related Disease	Score	Top Affiliating Genes
1	intracranial hypertension	31.0	APOH F2
2	intracranial hypertension, idiopathic	30.1	OGG1 PCLO
3	ischemic optic neuropathy	30.0	APOH F2
4	thrombophilia due to thrombin defect	30.0	APOH F2
5	cerebral sinovenous thrombosis	29.8	APOH F2
6	retinal vascular occlusion	29.8	APOH F2
7	cinca syndrome	29.5	IL1R1 NLRP3
8	hydrocephalus	11.3
9	papilloma of choroid plexus	11.2
10	optic papillitis	11.1
11	colloid cysts of third ventricle	10.9
12	anterior cranial fossa meningioma	10.4	F2 TP53
13	spinal cord infarction	10.4	APOH F2
14	livedoid vasculopathy	10.4	APOH F2
15	splenic infarction	10.4	APOH F2
16	prothrombin deficiency, congenital	10.4	APOH F2
17	squamous cell papilloma	10.4	F2 TP53
18	ischemic colitis	10.4	APOH F2
19	sneddon syndrome	10.4	APOH F2
20	retinal artery occlusion	10.4	APOH F2
21	buerger disease	10.4	APOH F2
22	hepatic infarction	10.4	APOH F2
23	prothrombin deficiency	10.4	APOH F2
24	thrombophlebitis	10.4	APOH F2
25	antithrombin iii deficiency	10.3	APOH F2
26	peripheral vertigo	10.3	APOH F2
27	central retinal vein occlusion	10.3	APOH F2
28	branch retinal artery occlusion	10.3	APOH F2
29	portal vein thrombosis	10.3	APOH F2
30	raynaud disease	10.3	APOH IL1R1
31	protein s deficiency	10.3	APOH F2
32	placental abruption	10.3	APOH F2
33	infective endocarditis	10.3	APOH F2
34	pyoderma	10.3	APOH IL1R1
35	intermittent claudication	10.2	APOH F2
36	cryopyrin-associated periodic syndrome	10.2	IL1R1 NLRP3
37	vulvar vestibulitis syndrome	10.2	IL1R1 NLRP3
38	cholecystitis	10.2	F2 TP53
39	cold urticaria	10.2	IL1R1 NLRP3
40	familial cold autoinflammatory syndrome 1	10.2	IL1R1 NLRP3
41	retinal vein occlusion	10.2	APOH F2
42	schnitzler syndrome	10.2	IL1R1 NLRP3
43	thrombophilia due to activated protein c resistance	10.2	APOH F2
44	barrett's adenocarcinoma	10.2	OGG1 TP53
45	aseptic meningitis	10.2	IL1R1 NLRP3
46	muckle-wells syndrome	10.2	IL1R1 NLRP3
47	wells syndrome	10.1	IL1R1 NLRP3
48	familial cold autoinflammatory syndrome	10.1	IL1R1 NLRP3
49	cerebritis	10.1
50	headache	10.1

Graphical network of the top 20 diseases related to Papilledema:

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Symptoms & Phenotypes for Papilledema

UMLS symptoms related to Papilledema:

edema

GenomeRNAi Phenotypes related to Papilledema according to GeneCards Suite gene sharing:

²⁵ (show all 36)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	10.04	PCLO
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	10.04	ARSB
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-110	10.04	ARSB
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	10.04	IL1R1 NLRP3 OGG1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-12	10.04	OGG1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	10.04	IL1R1 PCLO ARSB F2
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-123	10.04	OGG1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-124	10.04	IL1R1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	10.04	ARSB F2
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-127	10.04	NLRP3
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-133	10.04	F2
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-146	10.04	F2
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	10.04	F2
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-164	10.04	PCLO
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-166	10.04	PCLO
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	10.04	IL1R1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	10.04	F2
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	10.04	NLRP3
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-183	10.04	IL1R1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	10.04	OGG1
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	10.04	NLRP3
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-196	10.04	OGG1
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-198	10.04	IL1R1
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-202	10.04	OGG1
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-208	10.04	OGG1
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	10.04	PCLO NLRP3
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	10.04	IL1R1
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	10.04	ARSB
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	10.04	ARSB F2
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	10.04	PCLO
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-83	10.04	ARSB
32	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	10.04	IL1R1
33	Increased shRNA abundance (Z-score > 2)	GR00366-A-90	10.04	PCLO
34	Increased shRNA abundance (Z-score > 2)	GR00366-A-93	10.04	NLRP3
35	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	10.04	IL1R1
36	Increased proliferation	GR00094-A	8.96	IL1R1 TP53

MGI Mouse Phenotypes related to Papilledema:

⁴³

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.5	ARSB F2 IL1R1 NLRP3 OGG1 PCLO
2	normal	MP:0002873	9.1	F2 IL1R1 NLRP3 OGG1 PCLO TP53

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Drugs & Therapeutics for Papilledema

Drugs for Papilledema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Acetazolamide

Approved, Vet_approved

Phase 4,Phase 2,Phase 3

59-66-5

1986

Doxycycline

Approved, Investigational, Vet_approved

Phase 4

564-25-0

54671203

Isotretinoin

Approved

Phase 4

4759-48-2

5282379 5538

Lymecycline

Approved, Investigational

Phase 4

992-21-2

5280963

Minocycline

Approved, Investigational

Phase 4

10118-90-8

5281021

Anticonvulsants

Phase 4,Phase 2,Phase 3

Carbonic Anhydrase Inhibitors

Phase 4,Phase 2,Phase 3

diuretics

Phase 4,Phase 2,Phase 3

Natriuretic Agents

Phase 4,Phase 2,Phase 3

Anti-Bacterial Agents

Phase 4

Anti-Infective Agents

Phase 4

Dermatologic Agents

Phase 4

Acetaminophen

Approved

Phase 2, Phase 3

103-90-2

1983

Aspirin

Approved, Vet_approved

Phase 2, Phase 3

50-78-2

2244

Codeine

Approved, Illicit

Phase 2, Phase 3

76-57-3

5284371

Guaifenesin

Approved, Investigational, Vet_approved

Phase 2, Phase 3

93-14-1

3516

Ibuprofen

Approved

Phase 2, Phase 3

15687-27-1

3672

Naproxen

Approved, Vet_approved

Phase 2, Phase 3

22204-53-1

156391 1302

Dexamethasone

Approved, Investigational, Vet_approved

Phase 2, Phase 3

50-02-2

5743

Warfarin

Approved

Phase 3

81-81-2

54678486 6691

Analgesics

Phase 2, Phase 3

Analgesics, Non-Narcotic

Phase 2, Phase 3

Anti-Inflammatory Agents

Phase 2, Phase 3, Phase 1

Anti-Inflammatory Agents, Non-Steroidal

Phase 2, Phase 3

Antirheumatic Agents

Phase 2, Phase 3,Phase 1

Peripheral Nervous System Agents

Phase 2, Phase 3

glucocorticoids

Phase 2, Phase 3,Phase 1

Hormone Antagonists

Phase 2, Phase 3,Phase 1

Hormones

Phase 2, Phase 3,Phase 1

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 2, Phase 3,Phase 1

Analgesics, Opioid

Phase 2, Phase 3

Antipyretics

Phase 2, Phase 3

Antitussive Agents

Phase 2, Phase 3

Central Nervous System Depressants

Phase 2, Phase 3

Chlorpheniramine, phenylpropanolamine drug combination

Phase 2, Phase 3

Cyclooxygenase Inhibitors

Phase 2, Phase 3

Fibrinolytic Agents

Phase 2, Phase 3

Narcotics

Phase 2, Phase 3

Platelet Aggregation Inhibitors

Phase 2, Phase 3

Respiratory System Agents

Phase 2, Phase 3

Antiemetics

Phase 2, Phase 3

Antineoplastic Agents, Hormonal

Phase 2, Phase 3

Autonomic Agents

Phase 2, Phase 3

BB 1101

Phase 2, Phase 3

Dexamethasone acetate

Phase 2, Phase 3

1177-87-3

Gastrointestinal Agents

Phase 2, Phase 3

HIV Protease Inhibitors

Phase 2, Phase 3

protease inhibitors

Phase 2, Phase 3

Anticoagulants

Phase 3

Antithrombin III

Phase 3

Interventional clinical trials:

(show all 28)

#	Name	Status	NCT ID	Phase	Drugs
1	ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function	Unknown status	NCT00485238	Phase 4	Intravenous acetazolamide
2	Pegaptanib for Retinal Edema Secondary to Diabetic Vascular Disease(Preserve) Study	Completed	NCT01486238	Phase 4	Macugen® pegaptanib sodium
3	Antiacne Medications Pseudotumor Cerebri	Recruiting	NCT02149615	Phase 4
4	Idiopathic Intracranial Hypertension Treatment Trial	Completed	NCT01003639	Phase 2, Phase 3	Acetazolamide;Placebo
5	Ozurdex for Macular Edema Post Membrane Peeling	Completed	NCT01273727	Phase 2, Phase 3	Dexamethasone;dexamethasone
6	The Efficacy and Safety of Dabigatran Etexilate for the Treatment of Cerebral Venous Thrombosis	Recruiting	NCT03217448	Phase 3	Dabigatran etexilate;Warfarin
7	Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo	Unknown status	NCT01330524	Phase 1, Phase 2	Avastin and Triamcinolone
8	Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension.	Completed	NCT02017444	Phase 2	AZD4017
9	Efficacy of Biweekly Ranibizumab (0.5 mg) for Exudative Macular Degeneration Retinal Edema Refractory to Anti-VEGF	Not yet recruiting	NCT03071055	Phase 2	Ranibizumab Injection [Lucentis]
10	Intravitreal Aflibercept Injection for Radiation Retinopathy Trial	Not yet recruiting	NCT03085784	Phase 2	Aflibercept
11	Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease	Terminated	NCT00069329	Phase 1, Phase 2	anakinra
12	Endovascular Stenting Treatment for Patients With Internal Jugular Vein Stenosis	Not yet recruiting	NCT03373292	Phase 1
13	aICP in Glaucoma and Papilledema	Unknown status	NCT02410148
14	OCT Imaging of Papilledema in Pediatric Idiopathic Intracranial Hypertension	Unknown status	NCT02665858
15	Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery	Unknown status	NCT01847638		Prolensa (bromfenac 0.07%);Ilevro (nepafenac 0.3%)
16	Assessment of Retinal Nerve Fibre Layer by Optical Coherence Tomography in Uveitis Patients With Papilloedema	Completed	NCT01170481
17	Digital Ocular Fundus Photography in the Emergency Department: A New Application for Telemedicine?	Completed	NCT00873613
18	Observe the Effectiveness and Safety of Ranibizumab in Real Life Setting	Completed	NCT01318941		Ranibizumab
19	Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment Scales	Recruiting	NCT03273179
20	Measurement of Optic Nerve Sheath Diameter in Children Without the Increased Intracranial Pressure	Recruiting	NCT03178760
21	An RCT of Bariatric Surgery vs a Community Weight Loss Programme for the Sustained Treatment of IIH	Recruiting	NCT02124486
22	Astronaut Vision Issues in a Ground Analog Population: Polycystic Ovary Syndrome	Recruiting	NCT02896452
23	Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID / CAPS, DIRA, CANDLE, SAVI, CRMO, Still's Disease, Behcet's Disease, and Other Undifferentiated Autoinflammatory Diseases)	Recruiting	NCT00059748
24	Evaluating Raised Intracranial Pressure Using MR Elastography	Recruiting	NCT03096743
25	A Single-Center Trial of High Frequency Pegaptanib for Rapid Restoration of VEGF Levels in Diabetic Retinal Edema	Available	NCT01487044		Macugen (Pegaptanib Sodium)
26	Ocular Point of Care Ultrasound (POCUS) to Detect Optic Disc Swelling in Comparison to Ophthalmologic Examination	Not yet recruiting	NCT02992262
27	Operative Procedures vs. Endovascular Neurosurgery for Untreated Pseudotumor Trial	Not yet recruiting	NCT02513914
28	Disc Edema in Patients With Chronic Kidney Disease	Withdrawn	NCT00769834

Search NIH Clinical Center for Papilledema

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Genetic Tests for Papilledema

Genetic tests related to Papilledema:

#	Genetic test	Affiliating Genes
1	Papilledema ²⁸

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Anatomical Context for Papilledema

MalaCards organs/tissues related to Papilledema:

³⁸

Eye, Brain, Ovary, Spinal Cord, Kidney, Retina, Liver

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Publications for Papilledema

Articles related to Papilledema:

(show top 50) (show all 503)

#	Title	Authors	Year
1	Papilledema in Idiopathic Intracranial Hypertension. ( 29399792 )	Vgontzas A....Burch R.C.	2018
2	Arteriovenous ratio and papilledema based hybrid decision support system for detection and grading of hypertensive retinopathy. ( 29249337 )	Akbar S....Yasin U.U.	2018
3	Chronic papilledema in a child with classical tuberous sclerosis. ( 29283138 )	Jain K.A....Jain A.B.	2018
4	Five-Year-Old Boy With Behavioral Changes and Papilledema. ( 28991098 )	Ram R....Shah V.S.	2018
5	Headache and Papilledema in Guillain-BarrAc Syndrome. ( 29374500 )	Alrohimi A....Ba F.	2018
6	The efficacy of orbital ultrasonography and magnetic resonance imaging findings with direct measurement of intracranial pressure in distinguishing papilledema from pseudopapilledema. ( 28534259 )	Ozturk Z....Yalinbas D.	2017
7	Papilledema in children with hydrocephalus: incidence and associated factors. ( 28387641 )	Lee H.J....Kim S.J.	2017
8	Relationship between lamina cribrosa displacement and trans-laminar pressure difference in papilledema. ( 28391369 )	GarcA-a-Montesinos J....Rebolleda G.	2017
9	Retrospective analysis of translaminar, demographic, and physiologic parameters in relation to papilledema severity. ( 28237144 )	Fleischman D....Chesnutt D.A.	2017
10	Hypoparathyroidism Should Always Be Checked in Papilledema. ( 28694607 )	Gradisnik P.	2017
11	Papilledema: A Comprehensive Assessment. ( 29204042 )	Ferreira B.F.A.	2017
12	Vestibular Schwannoma Presenting with Bilateral Papilledema Without Hydrocephalus: Case Study. ( 29375948 )	Candanedo C....Spektor S.	2017
13	Myhre syndrome with novel findings: bilateral congenital cortical cataract, bilateral papilledema, accessory nipple, and adenoid hypertrophy. ( 28562390 )	Erdem H.B....Tatar A.	2017
14	Accuracy of Diagnostic Imaging Modalities for Classifying Pediatric Eyes as Papilledema Versus Pseudopapilledema. ( 28732589 )	Chang M.Y....Pineles S.L.	2017
15	Optical Coherence Tomography to Differentiate Papilledema from Pseudopapilledema. ( 28819712 )	Rebolleda G....MuA+oz-Negrete F.J.	2017
16	Accuracy of crescent sign on ocular ultrasound in diagnosing papilledema. ( 29026691 )	Bhosale A....Shah P.K.	2017
17	Unilateral Papilledema in Cerebral Venous Sinus Thrombosis. ( 28936083 )	Kulkarni G.B....Mustare V.	2017
18	Fully automated diagnosis of papilledema through robust extraction of vascular patterns and ocular pathology from fundus photographs. ( 28270999 )	Fatima K.N....Butt W.H.	2017
19	"Twin Peaks" Papilledema. ( 28126073 )	Nash D.L....Brodsky M.C.	2017
20	Utility of Intracranial Pressure Monitoring for Diagnosis of Idiopathic Intracranial Hypertension in the Absence of Papilledema. ( 29258930 )	Bridges K.J....Raslan A.M.	2017
21	Unexpected papilledema in a young male with Type 1 diabetes. ( 28781853 )	Paniagua J.A....Velasco F.	2017
22	New-Onset Isolated Asymptomatic Papilledema in Two Patients Treated With Recombinant Growth Hormone. ( 28952359 )	Kanner L.A....Frank G.	2017
23	Orbital Hydatid Cyst Causing Papilledema and Proptosis in an Adult. ( 28323190 )	Taghipour M....Dehghanian A.	2017
24	The diagnostic challenge of evaluating papilledema in the pediatric patient. ( 29018749 )	McCafferty B....Lee M.S.	2017
25	Commentary: The Dilemma of Papilledema in Chiari I Malformation. ( 29272471 )	Smith V....Lin J.	2017
26	Clinical Reasoning: A 57-year-old man with unilateral anosmia, papilledema, and meningismus. ( 28827465 )	Bradshaw M.J....Longmuir R.	2017
27	Sildenafil-related cerebral venous sinus thrombosis and papilledema: a case report of a rare entity. ( 28474148 )	Karti D.T....Celebisoy N.	2017
28	Use of A-scan Ultrasound and Optical Coherence Tomography to Differentiate Papilledema From Pseudopapilledema. ( 29120977 )	Saenz R....Tang R.A.	2017
29	Bruch's membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema. ( 29203329 )	Thompson A.C....El-Dairi M.A.	2017
30	Decision Support System for Detection of Papilledema through Fundus Retinal Images. ( 28283997 )	Akbar S....Yasin U.U.	2017
31	Factors Influencing the Incidence of Papilledema in Patients with Cerebral Venous Thrombosis. ( 29387676 )	Saadatnia M....Pirhaji Z.	2017
32	Complete Resolution of Papilledema in Syndromic Craniosynostosis with Posterior Cranial Vault Distraction. ( 28904587 )	Lopresti M....Lam S.	2017
33	Objective Measures of Visual Function in Papilledema. ( 28451649 )	Moss H.E.	2016
34	Use of MultiColor imaging in the assessment of suspected papilledema in 20 consecutive children. ( 27816749 )	Malem A....West S.	2016
35	The Optic Canal Size Is Associated With the Severity of Papilledema and Poor Visual Function in Idiopathic Intracranial Hypertension. ( 26580295 )	Bidot S....Bruce B.B.	2016
36	Measuring recovery of visual function in children with papilledema using sweep visual evoked potentials. ( 27164429 )	Mezer E....Buncic J.R.	2016
37	Papilledema and Spinal Ependymoma: When Eyes are Windows to the Spinal Cord. ( 27470690 )	Hussain A....Haines S.	2016
38	Papilledema as a Diagnostic Sign of Cerebral Edema on Postmortem Magnetic Resonance Imaging. ( 27571174 )	Neumann R....Flach P.M.	2016
39	Bilateral papilledema in a child with osteogenesis imperfecta. ( 27833926 )	Sendul S.Y....Guven D.	2016
40	Optical Coherence Tomography Imaging of Paton Folds in Papilledema With Retinopathy From Systemic Hypertension. ( 27737453 )	Kim M.J....Kelly S.P.	2016
41	Severe bilateral papilledema in acute lymphoblastic leukemia. ( 26873026 )	El Atiqi A....Daoudi R.	2016
42	Idiopathic Intracranial Hypertension in a Prepubertal Pediatric Japanese Patient Complicated by Severe Papilledema. ( 27065853 )	Oka A....Kondo M.	2016
43	Papilledema Due to Mirtazapine. ( 27308085 )	Ceylan M.E....CAPmert G.	2016
44	Papilledema secondary to a superior sagittal sinus thrombosis. Mantle cell lymphoma paraneoplastic syndrome. ( 26596713 )	Platas-Moreno I....Rosado Sierra M.B.	2016
45	Isolated central nervous system primary acute monoblastic leukemia presenting as papilledema. ( 27569601 )	Park C....Abromowitch M.	2016
46	Peripapillary retinal leukemic infiltration associated with papilledema in a T-ALL patient without cranial or optic nerve involvement. ( 26979244 )	A8ekiAs O....Esen F.	2016
47	Gaze Evoked Deformations of the Peripapillary Retina in Papilledema and Ischemic Optic Neuropathy. ( 27661851 )	Sibony P.A.	2016
48	Asymmetric Papilledema in Idiopathic Intracranial Hypertension: Comment. ( 26885711 )	Mader T.H....Lee A.G.	2016
49	"Paton's Folds" Revisited: Peripapillary Wrinkles, Folds, and Creases in Papilledema. ( 26778344 )	Sibony P.A....Kupersmith M.J.	2016
50	Abnormal transcranial Doppler cerebral blood flow velocity and blood pressure profiles in children with syndromic craniosynostosis and papilledema. ( 26857754 )	Spruijt B....Joosten K.F.	2016

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Genes for Papilledema

Genes related to Papilledema (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Implication
1	TP53	Tumor Protein P53	Protein Coding	21.34	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
2	F2	Coagulation Factor II, Thrombin	Protein Coding	20.88	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	APOH	Apolipoprotein H	Protein Coding	17.42	GeneCards inferred via : Publications (show sections)
4	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	17.42	GeneCards inferred via : Publications (show sections)
5	ARSB	Arylsulfatase B	Protein Coding	17.42	GeneCards inferred via : Publications (show sections)
6	OGG1	8-Oxoguanine DNA Glycosylase	Protein Coding	16.49	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
7	MYOM2	Myomesin 2	Protein Coding	16.18	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
8	PCLO	Piccolo Presynaptic Cytomatrix Protein	Protein Coding	16	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
9	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	15.24	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Papilledema

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Expression for Papilledema

Search GEO for disease gene expression data for Papilledema.

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Pathways for Papilledema

Pathways related to Papilledema according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	IL1 and megakaryocytes in obesity ¹	10.2	F2 IL1R1 NLRP3

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GO Terms for Papilledema

Biological processes related to Papilledema according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleotide-excision repair	GO:0006289	9.4	OGG1 TP53
2	base-excision repair	GO:0006284	9.37	OGG1 TP53
3	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.32	F2 TP53
4	regulation of blood coagulation	GO:0030193	9.26	APOH F2
5	blood coagulation, intrinsic pathway	GO:0007597	9.16	APOH F2
6	positive regulation of blood coagulation	GO:0030194	8.96	APOH F2
7	negative regulation of fibrinolysis	GO:0051918	8.62	APOH F2

Sources

Sources for Papilledema

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ ExPASy

¹⁷ FDA Approved Drugs

¹⁸ FMA

¹⁹ GeneAnalytics

²⁰ GeneCards

²¹ GeneGo (Thomson Reuters)

²² GeneHancer via GeneCards

²³ GeneReviews

²⁴ Genetics Home Reference

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HGMD

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ MalaCards

³⁹ MedGen

⁴⁰ MedlinePlus

⁴¹ MeSH

⁴² MESH via Orphanet

⁴³ MGI

⁴⁴ NCBI Bookshelf

⁴⁵ NCI

⁴⁶ NCIt

⁴⁷ NDF-RT

⁴⁸ NIH Clinical Center

⁴⁹ NIH Rare Diseases

⁵⁰ NINDS

⁵¹ Novoseek

⁵² Novus Biologicals

⁵³ OMIM

⁵⁴ OMIM via Orphanet

⁵⁵ Orphanet

⁵⁶ PathCards

⁵⁷ PharmGKB

⁵⁸ PubMed

⁵⁹ PubMed Health

⁶⁰ QIAGEN

⁶¹ R&D Systems

⁶² Reactome

⁶³ Sino Biological

⁶⁴ SNOMED-CT

⁶⁵ SNOMED-CT via HPO

⁶⁶ SNOMED-CT via Orphanet

⁶⁷ TGDB

⁶⁸ Tocris

⁶⁹ UMLS

⁷⁰ UMLS via Orphanet

⁷¹ UniProtKB/Swiss-Prot

⁷² Wikipedia