MCID: PPL021
MIFTS: 47

Papilledema malady

Categories: Rare diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Papilledema

Aliases & Descriptions for Papilledema:

Name: Papilledema 12 50 29 52 14 69
Edema of the Optic Disc 50
Choked Disk 50

Classifications:



Summaries for Papilledema

NIH Rare Diseases : 50 papilledema is a condition in which increased pressure in or around the brain (intracranial pressure) causes swelling of the part of the optic nerve inside the eye (optic disc). symptoms of increased intracranial pressure include headache or nausea and vomiting. vision problems are not common initially, but may include short flickers of gray vision, blurred or double vision, and decreased field of vision or ability to see colors. both eyes are usually affected. papilledema by definition is caused by increased cranial pressure. diagnosis includes a thorough eye exam by an ophthalmologist. brain imaging studies (for example ct scan or mri) are used to find the cause of the increased intracranial pressure. treatment depends on the cause of the increased pressure but may include medications, surgery and/or weight management. last updated: 8/31/2016

MalaCards based summary : Papilledema, also known as edema of the optic disc, is related to ischemic optic neuropathy and cinca syndrome, and has symptoms including edema and localized edema. An important gene associated with Papilledema is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways is IL1 and megakaryocytes in obesity. The drugs Acetazolamide and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and spinal cord, and related phenotypes are Increased proliferation and homeostasis/metabolism

Wikipedia : 71 Papilledema (or papilloedema) is optic disc swelling that is caused by increased intracranial pressure.... more...

Related Diseases for Papilledema

Diseases related to Papilledema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
id Related Disease Score Top Affiliating Genes
1 ischemic optic neuropathy 29.7 APOH F2
2 cinca syndrome 29.2 IL1R1 NLRP3
3 prostatitis 27.6 APOH ARSB F2 IL1R1 MYOM2 NEXN
4 hydrocephalus 11.1
5 choroid plexus papilloma 11.0
6 optic papillitis 11.0
7 colloid cysts of third ventricle 10.8
8 hypertensive encephalopathy 10.8
9 intracranial hypertension 10.3
10 vascular erectile tumor 10.3 APOH F2
11 lubinsky syndrome 10.3 APOH F2
12 supraumbilical midabdominal raphe and facial cavernous hemangiomas 10.3 APOH F2
13 landau-kleffner syndrome 10.3 APOH F2
14 hendra virus infection 10.3 APOH F2
15 may-hegglin anomaly 10.3 APOH F2
16 left-right axis malformations 10.3 APOH F2
17 lymphocytic colitis 10.3 APOH F2
18 spinal cord lipoma 10.3 APOH F2
19 bullous skin disease 10.3 APOH F2
20 glutathionuria 10.2 APOH F2
21 lynch syndrome 10.2 APOH F2
22 cryptosporidiosis 10.2 APOH F2
23 angular blepharoconjunctivitis 10.2 APOH F2
24 blepharoconjunctivitis 10.2 APOH F2
25 intestinal disaccharidase deficiency 10.2 APOH F2
26 dysgammaglobulinemia 10.2 APOH F2
27 seminoma 10.2 F2 TP53
28 sialadenitis 10.2 APOH IL1R1
29 ophthalmia neonatorum 10.2 APOH F2
30 autoimmune disease of central nervous system 10.2 APOH F2
31 central retinal artery occlusion 10.2 APOH F2
32 pregnancy loss, recurrent 2 10.2 APOH F2
33 red color blindness 10.2 F2 TP53
34 scar contracture 10.1 APOH F2
35 chronic recurrent multifocal osteomyelitis 10.1 NEXN OGG1
36 uterine corpus cancer 10.1 APOH F2
37 thrombophilia due to activated protein c resistance 10.1 APOH F2
38 tamoxifen-related endometrial lesion 10.1 OGG1 TP53
39 functional gastric disease 10.1 IL1R1 MYOM2
40 gonadal disease 10.1 F2 NLRP3
41 cutaneous sclerosis 10.1 IL1R1 NLRP3
42 muckle-wells syndrome 10.0 IL1R1 NLRP3
43 egg allergy 10.0 IL1R1 NLRP3
44 warthin tumor 10.0 IL1R1 NLRP3
45 coloboma of optic papilla 10.0 IL1R1 NLRP3
46 familial hyperthyroidism due to mutations in tsh receptor 10.0 IL1R1 NLRP3
47 mental retardation, autosomal dominant 22 10.0 IL1R1 NLRP3
48 senile reticular retinal degeneration 10.0 IL1R1 NLRP3
49 headache 10.0
50 malignant histiocytosis 10.0 IL1R1 NLRP3

Graphical network of the top 20 diseases related to Papilledema:



Diseases related to Papilledema

Symptoms & Phenotypes for Papilledema

UMLS symptoms related to Papilledema:


edema, localized edema

GenomeRNAi Phenotypes related to Papilledema according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 IL1R1 TP53

MGI Mouse Phenotypes related to Papilledema:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.17 F2 IL1R1 NLRP3 OGG1 TP53 APOH

Drugs & Therapeutics for Papilledema

Drugs for Papilledema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4,Phase 2,Phase 3 59-66-5 1986
2
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
3
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
4
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
5
Lymecycline Approved Phase 4 992-21-2 5280963
6 diuretics Phase 4,Phase 2,Phase 3
7 Natriuretic Agents Phase 4,Phase 2,Phase 3
8 Anticonvulsants Phase 4,Phase 2,Phase 3
9 Carbonic Anhydrase Inhibitors Phase 4,Phase 2,Phase 3
10 Dermatologic Agents Phase 4
11 Anti-Bacterial Agents Phase 4
12 Anti-Infective Agents Phase 4
13
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
14
Aspirin Approved, Vet_approved Phase 2, Phase 3 50-78-2 2244
15
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
16
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
17
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 1302 156391
18 Analgesics Phase 2, Phase 3
19 glucocorticoids Phase 2, Phase 3,Phase 1
20 Analgesics, Non-Narcotic Phase 2, Phase 3
21 Hormone Antagonists Phase 2, Phase 3,Phase 1
22 Hormones Phase 2, Phase 3,Phase 1
23 Peripheral Nervous System Agents Phase 2, Phase 3
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3,Phase 1
25 Anti-Inflammatory Agents Phase 2, Phase 3, Phase 1
26 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
27 Antirheumatic Agents Phase 2, Phase 3,Phase 1
28 Dexamethasone acetate Phase 2, Phase 3 1177-87-3
29
protease inhibitors Phase 2, Phase 3
30 Gastrointestinal Agents Phase 2, Phase 3
31 Cyclooxygenase Inhibitors Phase 2, Phase 3
32 HIV Protease Inhibitors Phase 2, Phase 3
33 Dexamethasone 21-phosphate Phase 2, Phase 3
34 Platelet Aggregation Inhibitors Phase 2, Phase 3
35 Fibrinolytic Agents Phase 2, Phase 3
36 Antiemetics Phase 2, Phase 3
37 Antipyretics Phase 2, Phase 3
38 BB 1101 Phase 2, Phase 3
39 Autonomic Agents Phase 2, Phase 3
40 Antineoplastic Agents, Hormonal Phase 2, Phase 3
41
Triamcinolone Approved, Vet_approved Phase 1, Phase 2 124-94-7 31307
42
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
43
Ranibizumab Approved Phase 2 347396-82-1 459903
44
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
45
Nicotinamide Approved, Nutraceutical Phase 2 98-92-0 936
46
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
47 triamcinolone acetonide Phase 1, Phase 2
48 Triamcinolone diacetate Phase 1, Phase 2
49 Triamcinolone hexacetonide Phase 1, Phase 2
50 Angiogenesis Inhibitors Phase 1, Phase 2

Interventional clinical trials:

(show all 25)
id Name Status NCT ID Phase
1 ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function Unknown status NCT00485238 Phase 4
2 Pegaptanib for Retinal Edema Secondary to Diabetic Vascular Disease(Preserve) Study Completed NCT01486238 Phase 4
3 Antiacne Medications Pseudotumor Cerebri Recruiting NCT02149615 Phase 4
4 Idiopathic Intracranial Hypertension Treatment Trial Completed NCT01003639 Phase 2, Phase 3
5 Ozurdex for Macular Edema Post Membrane Peeling Completed NCT01273727 Phase 2, Phase 3
6 Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo Unknown status NCT01330524 Phase 1, Phase 2
7 Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension. Completed NCT02017444 Phase 2
8 Efficacy of Biweekly Ranibizumab (0.5 mg) for Exudative Macular Degeneration Retinal Edema Refractory to Anti-VEGF Not yet recruiting NCT03071055 Phase 2
9 Intravitreal Aflibercept Injection for Radiation Retinopathy Trial Not yet recruiting NCT03085784 Phase 2
10 Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease Terminated NCT00069329 Phase 1, Phase 2
11 aICP in Glaucoma and Papilledema Unknown status NCT02410148
12 Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery Unknown status NCT01847638
13 Assessment of Retinal Nerve Fibre Layer by Optical Coherence Tomography in Uveitis Patients With Papilloedema Completed NCT01170481
14 Digital Ocular Fundus Photography in the Emergency Department: A New Application for Telemedicine? Completed NCT00873613
15 Observe the Effectiveness and Safety of Ranibizumab in Real Life Setting Completed NCT01318941
16 Measurement of Optic Nerve Sheath Diameter in Children Without the Increased Intracranial Pressure Recruiting NCT03178760
17 An RCT of Bariatric Surgery vs a Community Weight Loss Programme for the Sustained Treatment of IIH Recruiting NCT02124486
18 Astronaut Vision Issues in a Ground Analog Population: Polycystic Ovary Syndrome Recruiting NCT02896452
19 Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID / CAPS, DIRA, CANDLE, SAVI, CRMO, Still's Disease, Behcet's Disease, and Other Undifferentiated Autoinflammatory Diseases) Recruiting NCT00059748
20 Evaluating Raised Intracranial Pressure Using MR Elastography Recruiting NCT03096743
21 A Single-Center Trial of High Frequency Pegaptanib for Rapid Restoration of VEGF Levels in Diabetic Retinal Edema Available NCT01487044
22 Ocular Point of Care Ultrasound (POCUS) to Detect Optic Disc Swelling in Comparison to Ophthalmologic Examination Not yet recruiting NCT02992262
23 OCT Imaging of Papilledema in Pediatric Idiopathic Intracranial Hypertension Not yet recruiting NCT02665858
24 Operative Procedures vs. Endovascular Neurosurgery for Untreated Pseudotumor Trial Not yet recruiting NCT02513914
25 Disc Edema in Patients With Chronic Kidney Disease Withdrawn NCT00769834

Search NIH Clinical Center for Papilledema

Genetic Tests for Papilledema

Genetic tests related to Papilledema:

id Genetic test Affiliating Genes
1 Papilledema 29

Anatomical Context for Papilledema

MalaCards organs/tissues related to Papilledema:

39
Eye, Brain, Spinal Cord, Retina, Heart, Liver, Prostate

Publications for Papilledema

Articles related to Papilledema:

(show top 50) (show all 469)
id Title Authors Year
1
Papilledema and Spinal Ependymoma: When Eyes are Windows to the Spinal Cord. ( 27470690 )
2016
2
Papilledema Due to Mirtazapine. ( 27308085 )
2016
3
Abnormal transcranial Doppler cerebral blood flow velocity and blood pressure profiles in children with syndromic craniosynostosis and papilledema. ( 26857754 )
2016
4
Isolated central nervous system primary acute monoblastic leukemia presenting as papilledema. ( 27569601 )
2016
5
Bilateral papilledema in a child with osteogenesis imperfecta. ( 27833926 )
2016
6
A case of POEMS and chronic papilledema with preserved optic nerve function. ( 26874176 )
2016
7
Measuring recovery of visual function in children with papilledema using sweep visual evoked potentials. ( 27164429 )
2016
8
"Paton's Folds" Revisited: Peripapillary Wrinkles, Folds, and Creases in Papilledema. ( 26778344 )
2016
9
Gaze Evoked Deformations of the Peripapillary Retina in Papilledema and Ischemic Optic Neuropathy. ( 27661851 )
2016
10
Idiopathic Intracranial Hypertension in a Prepubertal Pediatric Japanese Patient Complicated by Severe Papilledema. ( 27065853 )
2016
11
Severe bilateral papilledema in acute lymphoblastic leukemia. ( 26873026 )
2016
12
Asymmetric Papilledema in Idiopathic Intracranial Hypertension: Comment. ( 26885711 )
2016
13
The Optic Canal Size Is Associated With the Severity of Papilledema and Poor Visual Function in Idiopathic Intracranial Hypertension. ( 26580295 )
2016
14
Papilledema secondary to a superior sagittal sinus thrombosis. Mantle cell lymphoma paraneoplastic syndrome. ( 26596713 )
2016
15
Optical Coherence Tomography Imaging of Paton Folds in Papilledema With Retinopathy From Systemic Hypertension. ( 27737453 )
2016
16
Use of MultiColor imaging in the assessment of suspected papilledema in 20 consecutive children. ( 27816749 )
2016
17
Peripapillary retinal leukemic infiltration associated with papilledema in a T-ALL patient without cranial or optic nerve involvement. ( 26979244 )
2016
18
Papilledema as a Diagnostic Sign of Cerebral Edema on Postmortem Magnetic Resonance Imaging. ( 27571174 )
2016
19
Asymmetric papilledema in idiopathic intracranial hypertension. ( 25494197 )
2015
20
Papilledema in an otherwise clinically typical case of Miller Fisher syndrome. ( 26455984 )
2015
21
Papilledema From Intraventricular Neurocysticercosis. ( 26010581 )
2015
22
Relationship between Optic Nerve Protrusion Measured by OCT and MRI and Papilledema Severity. ( 25783602 )
2015
23
Cilioretinal Artery Territory Infarction Associated With Papilledema in a Patient With Neurofibromatosis Type 2. ( 26295608 )
2015
24
Retinal and Choroidal Folds in Papilledema. ( 26335066 )
2015
25
Ayurvedic management of papilledema. ( 27011720 )
2015
26
Asymmetric Papilledema in Idiopathic Intracranial Hypertension: Response. ( 26218626 )
2015
27
A 55-year-old man with severe papilledema. ( 25734739 )
2015
28
Papilledema from craniosynostosis in pycnodysostosis. ( 25451018 )
2015
29
Intracranial Hypertension in Children without Papilledema. ( 26933598 )
2015
30
An alternate technique for assessing optic nerve in papilledema by ultrasound B scan. ( 25921967 )
2015
31
Emergency Point-of-Care Ultrasound Detection of Papilledema in the Pediatric Emergency Department. ( 26535499 )
2015
32
A Rare Case of Glomus Jugulare Tumor Presenting as Papilledema. ( 26222371 )
2015
33
Retinal nerve fiber layer thickness analysis in cases of papilledema using optical coherence tomography a89 A case control study. ( 26093225 )
2015
34
Asymmetric Papilledema in Idiopathic Intracranial Hypertension: Comment. ( 26196848 )
2015
35
Effect of spatial resolution of T2-weighted imaging on diagnostic efficacy of MRI in detection of papilledema. ( 25714291 )
2015
36
Outcome of pediatric patients referred for papilledema. ( 26235795 )
2015
37
Intracranial Hypertension Without Papilledema in Children. ( 26012507 )
2015
38
Papilledema Outcomes from the Optical Coherence Tomography Substudy of the Idiopathic Intracranial Hypertension Treatment Trial. ( 26198807 )
2015
39
Papilledema in a Hypertensive Adult With Grade 4 Retinopathy. ( 25884103 )
2015
40
Optic disc drusen mimicking papilledema in an infant with Joubert syndrome. ( 26043505 )
2015
41
Relationship Between Pattern Electroretinogram, Frequency-Domain OCT, and Automated Perimetry in Chronic Papilledema From Pseudotumor Cerebri Syndrome. ( 26047166 )
2015
42
SD-OCT to distinguish papilledema from pseudopapilledema. ( 26148443 )
2015
43
Bilateral papilledema as the first sign of ventriculoperitoneal shunt dysfunctionAs. ( 25834657 )
2015
44
CSF pressure, papilledema grade, and response to acetazolamide in the Idiopathic Intracranial Hypertension Treatment Trial. ( 26159101 )
2015
45
Cerebral proliferative angiopathy with papilledema. ( 26355910 )
2015
46
Papilledema and Vision Loss Caused by Jugular Paragangliomas. ( 26079334 )
2015
47
Retinal Atrophy in Eyes With Resolved Papilledema Detected by Optical Coherence Tomography. ( 25742060 )
2015
48
Papilledema: a case of bilateral blurred vision caused by idiopathic intracranial hypertension. ( 25770576 )
2015
49
Chronic papilledema with vision loss as the presenting feature in racemose neurocysticercosis. ( 24513377 )
2014
50
Optical coherence tomography in papilledema and pseudopapilledema with and without optic nerve head drusen. ( 25579359 )
2014

Variations for Papilledema

Expression for Papilledema

Search GEO for disease gene expression data for Papilledema.

Pathways for Papilledema

Pathways related to Papilledema according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.2 F2 IL1R1 NLRP3

GO Terms for Papilledema

Biological processes related to Papilledema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleotide-excision repair GO:0006289 9.4 OGG1 TP53
2 base-excision repair GO:0006284 9.37 OGG1 TP53
3 positive regulation of reactive oxygen species metabolic process GO:2000379 9.32 F2 TP53
4 regulation of blood coagulation GO:0030193 9.26 APOH F2
5 blood coagulation, intrinsic pathway GO:0007597 9.16 APOH F2
6 positive regulation of blood coagulation GO:0030194 8.96 APOH F2
7 negative regulation of fibrinolysis GO:0051918 8.62 APOH F2

Molecular functions related to Papilledema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 damaged DNA binding GO:0003684 8.96 OGG1 TP53
2 structural constituent of muscle GO:0008307 8.62 MYOM2 NEXN

Sources for Papilledema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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