MCID: PPL022
MIFTS: 64

Papilloma malady

Summaries for Papilloma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A cell type benign neoplam that is composed of epithelial tissue on papillae of vascularized connective tissue.

MalaCards: Papilloma, also known as papillomatosis, is related to inverted papilloma and choroid plexus papilloma. An important gene associated with Papilloma is UBE3A (ubiquitin protein ligase E3A), and among its related pathways are MicroRNAs in cancer and Pathways in cancer. The drugs podophyllin and podophyllin pwdr and the compounds paraffin and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and cervix, and related mouse phenotypes are cellular and integument.

Wikipedia:63 Papilloma (plural papillomas or papillomata) (papillo- + -oma) refers to a benign epithelial tumor... more...

Aliases & Classifications for Papilloma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

papilloma 8 10 44 60
papillomatosis 8 44 60
papillomatosis, nos 8
papillomatosis nos 8


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Disease Ontology8 DOID:2615
NCIt39 C7440
MeSH34 D010212

Related Diseases for Papilloma

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17GeneCards, 18GeneDecks
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Diseases related to Papilloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 439)
idRelated DiseaseScoreTop Affiliating Genes
1inverted papilloma31.6KRT13, KRT20, FSCN1, PCNA, CDKN1B, MKI67
2choroid plexus papilloma31.4CT49, S100B
3squamous cell carcinoma31.0TP53, TP63, ACTC1, KRT13, KRT20, RASSF1
4cervical cancer30.7TP53, RASSF1, FGFR3, CDKN1B, CDKN1A, CDKN2A
5bladder transitional cell papilloma30.6FGFR3
6papillary carcinoma30.6TP63, ACTC1, KRT20, CDKN1B, MKI67, IFI27
7bladder carcinoma30.5TP53, ACTC1, KRT20, RASSF1, FGFR3, CDKN1A
8transitional cell carcinoma30.5TP53, TP63, KRT20, FGFR3, PCNA, CDKN1A
9adenocarcinoma30.4TP53, TP63, ACTC1, KRT13, KRT20, RASSF1
10bladder transitional cell carcinoma30.3TP53, KRT20, MKI67, IFI27
11ductal carcinoma in situ30.2TP53
12adenoma30.2TP53, TP63, ACTC1, KRT13, KRT20, RASSF1
13breast cancer30.2TP53, TP63, LALBA, RASSF1, FSCN1, FGFR3
14cholangiocarcinoma30.2TP53, KRT20, RASSF1, CDKN1B
15retinoblastoma30.1TP53, RASSF1, FGFR3, PCNA, CDKN1B, CDKN1A
16laryngeal squamous cell carcinoma30.1TP53, TP63, PCNA, CDKN1A, CDKN2A, MKI67
17lichen planus30.1KRT13
18meningioma30.1PCNA, MKI67
19lung cancer30.0TP53, TP63, KRT20, FSCN1, PCNA, CDKN1A
20neuroendocrine carcinoma30.0TP63, KRT20, FSCN1, S100B
21keratoacanthoma30.0PCNA, CDKN1A, MKI67
22melanoma29.8TP53, TP63, ACTC1, RASSF1, FSCN1, FGFR3
23bladder carcinoma in situ29.8TP53, KRT20, RASSF1, FGFR3, PCNA, CDKN2A
24cervical squamous cell carcinoma29.8TP63, RASSF1, CDKN1B, CDKN1A, CDKN2A, MKI67
25hemangioma29.8ACTC1
26choroid plexus carcinoma29.8CT49, S100B
27seborrheic keratosis29.7FGFR3
28colorectal cancer29.6TP53, KRT20, RASSF1, FSCN1, FGFR3, PCNA
29astrocytoma29.6TP53, RASSF1, FSCN1, PCNA, CDKN1B, CDKN1A
30adenoid cystic carcinoma29.6TP63, ACTC1, KRT20, RASSF1, PCNA, MKI67
31non-small cell lung carcinoma29.6TP53, TP63, RASSF1, PCNA, CDKN1A, CDKN2A
32prostate cancer29.6TP63, PCNA, CDKN1B, CDKN1A, MKI67, CT49
33sarcoma29.6TP53, TP63, ACTC1, FSCN1, MKI67, S100B
34cervical adenocarcinoma29.6KRT20, RASSF1, CDKN1B, CDKN1A, CDKN2A, IFI27
35mucoepidermoid carcinoma29.6TP63, ACTC1, KRT13, PCNA, CDKN1B, MKI67
36lung small cell carcinoma29.6TP53, TP63, KRT20, RASSF1, CDKN2A, CT49
37medulloblastoma29.6TP53, ACTC1, RASSF1, CT49, S100B
38basal cell carcinoma29.6TP53, TP63, ACTC1, KRT20, MKI67
39leiomyoma29.6ACTC1, PCNA, MKI67, S100B
40synovial sarcoma29.6KRT13, RASSF1, MKI67, S100B
41papillary thyroid carcinoma29.6TP63, RASSF1, CT49, IFI27
42colon adenocarcinoma29.6KRT20, CDKN1B, CDKN1A
43endometrial carcinoma29.6TP53, RASSF1, CDKN2A, IFI27
44esophageal cancer29.6TP53, CDKN2A
45histiocytosis29.6FSCN1, S100B
46tongue cancer29.6CDKN1A
47adenocarcinoma in situ29.6CDKN2A
48endometriosis29.6ACTC1
49li-fraumeni syndrome29.6TP53, CDKN2A
50parathyroid adenoma29.6CDKN1B

Graphical network of the top 20 diseases related to Papilloma:



Diseases related to papilloma

Clinical Features for Papilloma

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Drugs & Therapeutics for Papilloma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Papilloma

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Anatomical Context for Papilloma

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32MalaCards
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MalaCards organs/tissues related to Papilloma:

32
Breast, Skin, Cervix, Bone, Lung, Testes, Salivary gland, Prostate, Tongue, Endothelial, T cells, Brain, Lymph node, Kidney, Pineal, Ovary, Pituitary, Thyroid, Tonsil, Spinal cord, Temporal lobe, Liver, Trachea, Colon, Smooth muscle

Animal Models for Papilloma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Papilloma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.4UBE3A, CDKN2A, CDKN1A, CDKN1B, PCNA, FGFR3
2MP:001077111.1TP53, S100B, UBE3A, CDKN2A, CDKN1A, CDKN1B
3MP:000538711.1CDKN1A, CDKN1B, PCNA, FGFR3, FSCN1, RASSF1
4MP:000200611.0CDKN2A, CDKN1A, CDKN1B, FGFR3, RASSF1, TP63
5MP:000537910.9UBE3A, CDKN2A, CDKN1A, CDKN1B, LALBA, TP53
6MP:000301210.9UBE3A, CDKN2A, CDKN1A, CDKN1B, PCNA, FGFR3
7MP:000538910.7UBE3A, CDKN2A, CDKN1A, CDKN1B, PCNA, FGFR3

Publications for Papilloma

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50PubMed
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Articles related to Papilloma:

(show top 50)    (show all 1496)
idTitleAuthorsYear
1
One Lung Wheezing due to Endobronchial Solitary Papilloma. (24171131)
2013
2
Intraductal papilloma: atypical presentation. (23762648)
2013
3
High-risk human papilloma virus infection of the foreskin in asymptomatic boys. (23337104)
2013
4
Human papilloma virus infection in head and neck cancer. (23555322)
2013
5
The expression and significance of smac, XIAP, caspase-3 in nonnasal inverted papilloma]. (23156805)
2012
6
Benign mA1llerian papilloma of the cervix. (22935300)
2012
7
Analysis on expression of survivin and PTEN in vocal cords polyps, papilloma of larynx and laryngeal squamous cell carcinoma]. (23167185)
2012
8
Expression of P-glycoprotein is positively correlated with p53 in human papilloma virus induced squamous intraepithelial lesions of uterine cervix: poor prognosis association. (23464400)
2012
9
Streptococci-human papilloma virus interaction with ethanol exposure leads to keratinocyte damage. (22079067)
2012
10
Malignant transformation of exophytic Schneiderian papilloma of the nasal cavity. (22360508)
2012
11
Human papilloma virus: a new risk factor in a subset of head and neck cancers. (22044803)
2011
12
Expression of matrix metalloproteinases (MMP-2 and MMP-9) in recurrent respiratory papillomas and laryngeal carcinoma: clinical and morphological parallels. (21259063)
2011
13
Detection and genotyping of human papilloma virus in cervical cancer specimens from Saudi patients. (21697680)
2011
14
Evaluation of inverted papilloma and squamous cell carcinoma by nasal contact endoscopy. (20537289)
2010
15
Intraductal papilloma of ectopic breast tissue in axillary lymph node of a patient with a previous intraductal papilloma of ipsilateral breast: a case report and review of the literature. (20222992)
2010
16
The development of multiple cutaneous inverted papilloma following ovariohysterectomy in a dog. (20514092)
2010
17
Novel human papilloma virus (HPV) genotypes in children with recurrent respiratory papillomatosis. (20213305)
2010
18
Intraductal papilloma arising from sublingual minor salivary gland: case report and immunohistochemical study. (19426904)
2009
19
External vs endoscopic approach for inverted papilloma of the sino-nasal cavities: a retrospective study of 136 cases. (18607887)
2008
20
Complicated solitary intraductal papilloma of the breast. (17971167)
2008
21
Positive positron emission tomography/computed tomography in early inverted papilloma of the maxillary sinus. (17947736)
2007
22
Potential of diallyl sulfide bearing pH-sensitive liposomes in chemoprevention against DMBA-induced skin papilloma. (17622315)
2007
23
Low frequency of molecular changes and tumor recurrence in inverted papillomas of the urinary tract. (17527084)
2007
24
Choroid plexus papilloma in a Scottish highland cow. (16952368)
2006
25
A study on the clinical profile and management of inverted Papilloma. (23120235)
2006
26
Identification of genes and gene ontology processes critical to skin papilloma development in Tg.AC transgenic mice. (16329151)
2006
27
Is surveillance necessary for inverted papilloma in the urinary bladder and urethra? (15839967)
2005
28
Choroid plexus papilloma associated with developmental delay. (15345882)
2004
29
Choroid plexus papilloma and meningioma: coincidental posterior fossa tumors: case report and review of the literature. (14505866)
2003
30
Expression of the the cyclin-kinase inhibitors p21(WAF1) and p27(Kip1) and the p53 tumor suppressor genes in adult-onset laryngeal papillomas. (12434183)
2002
31
Segmental myoclonus as the sole manifestation of a choroid plexus papilloma in the posterior fossa. Case report. (11780907)
2001
32
Urinary bladder transitional cell papilloma in a shorthorn heifer. (11062838)
2000
33
Optimum management of inverted papilloma. (10829107)
2000
34
The neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL/6 mice. (10844550)
2000
35
Management of inverted papilloma via Denker's approach. (10196654)
1999
36
Bilateral cavernous malformations resulting from cranial irradiation of a choroid plexus papilloma. (9713844)
1998
37
Expression of p53 in normal nasal mucosa and in sinonasal papillomas with and without associated carcinoma and the relation to human papillomavirus (HPV). (9683277)
1998
38
Suppression of mouse skin papilloma by canthaxanthin and beta-carotene in vivo: possibility of the regression of tumorigenesis by carotenoids without conversion to retinoic acid. (8875557)
1996
39
12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mice expressing epidermal-targeted v-fos induces rasHA-activated papillomas and carcinomas without p53 mutation: association of v-fos expression with promotion and tumor autonomy. (7544154)
1995
40
Primary choroid plexus papilloma of the cerebellopontine angle: magnetic resonance imaging, computed tomographic and angiographic appearances. (1393408)
1992
41
Inverted papilloma of the urinary bladder with granular eosinophilic cells. An unusual neuroendocrine variant. (1863191)
1991
42
The operative management of intraductal papilloma of the breast. (2342242)
1990
43
Focal glial differentiation and oncocytic transformation in choroid plexus papilloma. (3564908)
1987
44
Malignant transformation in inverted papilloma. (3970504)
1985
45
Inverted papilloma of the urinary bladder: report of two cases. (6528846)
1984
46
Clinical significance of anteroinferior cerebellar artery in angiographic diagnosis of choroid plexus papilloma at the cerebellopontine angle. (6413141)
1983
47
Vulvar intraepithelial neoplasia: correlation of nuclear DNA content and the presence of a human papilloma virus (HPV) structural antigen. (6277449)
1982
48
Choroid plexus papilloma of the third ventricle. (7280976)
1981
49
Intraductal papilloma arising in supernumerary vulvar breast tissue. (7360456)
1980
50
Inverted papilloma and papillary transitional cell carcinoma of urinary bladder: report of four cases of inverted papilloma, one showing papillary malignant transformation and review of the literature. (361216)
1978

Genetic Variations for Papilloma

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Expression for genes affiliated with Papilloma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papilloma

Search GEO for disease gene expression data for Papilloma.

Pathways for genes affiliated with Papilloma

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29KEGG, 53Reactome, 4Cell Signaling Technology, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 12EMD Millipore
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Pathways related to Papilloma according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0TP53, CDKN2A, CDKN1A, CDKN1B, FGFR3, FSCN1
210.9CDKN2A, CDKN1A, CDKN1B, FGFR3, RASSF1, TP53
3
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10.9FGFR3, CDKN1B, CDKN1A, UBE3A, S100B, IFI27
4
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10.9TP63, PCNA, CDKN1B, CDKN1A, CDKN2A, MKI67
510.8UBE3A, CDKN2A, CDKN1A, CDKN1B, TP53
6
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10.8CDKN2A, CDKN1A, CDKN1B, PCNA, TP53
710.8CDKN2A, CDKN1A, CDKN1B, PCNA, TP53
810.8TP53, FGFR3, CDKN1B, CDKN1A
910.8TP53, TP63, CDKN1A, CDKN2A
10
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10.8TP53, CDKN1B, CDKN1A, CDKN2A
11
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10.8CDKN2A, CDKN1A, CDKN1B, TP53
1210.8CDKN2A, CDKN1A, CDKN1B, TP53
13
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10.8TP53, CDKN1B, CDKN1A, CDKN2A
14
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10.8TP53, CDKN1B, CDKN1A, CDKN2A
15
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10.8S100B, CDKN1A, CDKN1B, FGFR3
1610.8CDKN1A, PCNA, TP63, TP53
17
Hide members
10.8TP53, PCNA, CDKN1B, CDKN1A
1810.8TP53, PCNA, CDKN1B, CDKN1A
19
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10.8CDKN1A, CDKN1B, PCNA, TP53
2010.8CDKN2A, CDKN1A, PCNA, TP53
21
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10.8PCNA, CDKN1B, CDKN1A, CDKN2A
22
Cell cycle Cell cycle (generic schema)
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10.8PCNA, CDKN1B, CDKN1A, CDKN2A
23
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10.7TP53, FGFR3, UBE3A
24
Hide members
10.7CDKN1A, FGFR3, TP53
25
Transcription P53 signaling pathway
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10.7TP53, CDKN1A, CDKN2A
2610.7CDKN1A, PCNA, TP53
2710.7TP53, PCNA, CDKN1A
28
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10.6TP63, TP53
2910.5CDKN1A

Compounds for genes affiliated with Papilloma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Papilloma according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1paraffin4412.0CDKN1B, TP53, TP63, ACTC1, KRT13, KRT20
2retinoic acid44 2412.9S100B, CT49, MKI67, CDKN2A, CDKN1A, CDKN1B
3progesterone44 59 28 11 2415.8CDKN1A, LALBA, ACTC1, IFI27, S100B, CT49
4vegf4411.8IFI27, S100B, TP53, TP63, ACTC1, KRT20
5tyrosine4411.7S100B, IFI27, KRT20, TP63, ACTC1, LALBA
6doxorubicin44 49 1113.6TP53, TP63, FGFR3, CDKN1B, CDKN1A, CDKN2A
7testosterone44 59 11 2414.6PCNA, KRT20, ACTC1, TP63, CT49, CDKN1B
8arginine4411.6MKI67, TP53, TP63, PCNA, LALBA, FGFR3
9cisplatin44 49 59 1114.5CDKN2A, TP63, RASSF1, CDKN1A, MKI67, IFI27
10thymidine44 2412.5IFI27, TP53, TP63, PCNA, CDKN1B, CDKN1A
11oligonucleotide4411.5TP53, IFI27, CDKN2A, PCNA, CDKN1A, CDKN1B
12threonine4411.5CDKN1A, MKI67, S100B, CDKN2A, IFI27, RASSF1
13serine4411.4FSCN1, CDKN1A, CDKN1B, RASSF1, TP53, FGFR3
14hematoxylin4411.4KRT20, PCNA, MKI67, ACTC1, TP63, S100B
15bromodeoxyuridine4411.4S100B, IFI27, MKI67, CDKN1A, CDKN1B, PCNA
16steroid4411.4UBE3A, CT49, IFI27, CDKN2A, ACTC1, LALBA
17paclitaxel44 49 1113.3S100B, TP53, CDKN1A, CDKN2A, IFI27, CDKN1B
18cytarabine44 49 1113.3IFI27, CDKN2A, CDKN1B, PCNA, CDKN1A, TP53
19p0034411.3RASSF1, S100B, IFI27, MKI67, CDKN1B, TP63
20thymidylate4411.3IFI27, PCNA, TP53, CDKN2A, CDKN1A, MKI67
21mg 13244 5912.3TP53, PCNA, CDKN1B, CDKN2A, IFI27, CDKN1A
22formaldehyde44 2412.3S100B, MKI67, PCNA, KRT20, ACTC1, CDKN1B
235-aza-2deoxycytidine4411.3CDKN2A, PCNA, CT49, CDKN1A, RASSF1, TP53
24alanine4411.3S100B, PCNA, CDKN2A, CT49, RASSF1, UBE3A
25b 7234411.2KRT20, ACTC1, S100B, TP63, PCNA
265fluorouracil4411.2TP53, CDKN2A, PCNA, MKI67, CDKN1B, CDKN1A
27roscovitine4411.2CDKN2A, IFI27, TP53, PCNA, CDKN1A
28n acetylcysteine4411.2TP53, CDKN1A, IFI27, PCNA, CDKN1B, CDKN2A
29tamoxifen44 49 28 1114.2PCNA, IFI27, TP53, MKI67, CDKN1A, CDKN1B
30hpvs4411.2CDKN1A, TP53, UBE3A, CDKN2A
31mucicarmine4411.1ACTC1, S100B, TP63, KRT20
32olomoucine44 1112.1CDKN2A, PCNA, TP53, CDKN1A
33temozolomide44 1112.1TP53, PCNA, CDKN1A, CDKN2A
34troglitazone44 28 59 1114.1KRT20, CDKN1B, CDKN1A, IFI27, KRT13
35o6-methylguanine4411.1PCNA, TP53, CDKN2A, RASSF1
36eb 108944 5912.1IFI27, CDKN1A, CDKN1B, PCNA
37aphidicolin4411.1PCNA, CDKN1A, CDKN1B, TP53
38camptothecin44 59 1113.1CDKN2A, TP53, PCNA, CDKN1B, CDKN1A
39indole-3-carbinol4411.1TP53, CDKN1A, IFI27, CDKN1B
40sulindac44 1112.0CDKN1A, TP53, PCNA, IFI27
41estrogen4411.0LALBA
42imatinib44 49 1113.0ACTC1, S100B, CDKN1A, CDKN1B, FGFR3
43methanol44 2412.0LALBA, ACTC1, CDKN2A, MKI67
44acnu4410.9TP53, CDKN1A, CDKN2A
45flavopiridol44 1111.8CDKN1B, CDKN2A, CDKN1A, TP53
46norcantharidin4410.8IFI27, PCNA, MKI67
47celecoxib44 59 28 49 11 2415.8CDKN1A, CDKN1B, PCNA, MKI67
482-methoxyethanol4410.7TP63, ACTC1, UBE3A
49reticulin4410.6S100B, ACTC1, PCNA
50dexamethasone44 49 28 1113.5IFI27, CDKN2A, PCNA, S100B, CDKN1B

GO Terms for genes affiliated with Papilloma

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16Gene Ontology
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Cellular components related to Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.0S100B, UBE3A, MKI67, CDKN2A, CDKN1B, PCNA
2nucleoplasmGO:00565410.9CDKN1A, CDKN1B, PCNA, TP63, TP53, CDKN2A
3PCNA-p21 complexGO:07055710.5PCNA, CDKN1A

Biological processes related to Papilloma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cell cycle arrestGO:00705011.1TP53, RASSF1, CDKN1B, CDKN1A, CDKN2A
2Ras protein signal transductionGO:00726511.0TP53, RASSF1, CDKN1A, CDKN2A
3cell proliferationGO:00828311.0S100B, MKI67, PCNA, FSCN1, TP53
4negative regulation of cell growthGO:03030811.0CDKN2A, CDKN1A, CDKN1B, TP53
5mitotic cell cycle arrestGO:07185011.0CDKN1A, CDKN1B, TP53
6phosphatidylinositol-mediated signalingGO:04801511.0CDKN1A, CDKN1B, PCNA, FGFR3
7negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:04573610.9CDKN2A, CDKN1A, CDKN1B
8negative regulation of phosphorylationGO:04232610.9CDKN1B, CDKN1A, CDKN2A
9negative regulation of apoptotic processGO:04306610.9CDKN1A, CDKN1B, FGFR3, TP63, TP53
10DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00697710.8TP53, CDKN1B, CDKN1A
11G1/S transition of mitotic cell cycleGO:00008210.7PCNA
12activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.7CDKN1B, CDKN2A, IFI27
13DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.6TP53, TP63
14mitotic G1 DNA damage checkpointGO:03157110.5TP63, TP53
15replicative senescenceGO:09039910.3TP53, CDKN2A

Molecular functions related to Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.1S100B, UBE3A, MKI67, CDKN2A, CDKN1A, CDKN1B
2identical protein bindingGO:04280210.8TP53, TP63, RASSF1, PCNA, S100B
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.8CDKN1B, CDKN1A, CDKN2A
4MDM2/MDM4 family protein bindingGO:09737110.6TP53, CDKN2A
5p53 bindingGO:00203910.6CDKN2A, TP63, TP53

Products for genes affiliated with Papilloma

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Sources for Papilloma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet