MCID: PPL022
MIFTS: 64

Papilloma malady

Summaries for Papilloma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A cell type benign neoplam that is composed of epithelial tissue on papillae of vascularized connective tissue.

MalaCards: Papilloma, also known as papillomatosis, is related to inverted papilloma and choroid plexus papilloma. An important gene associated with Papilloma is UBE3A (ubiquitin protein ligase E3A), and among its related pathways are MicroRNAs in cancer and Pathways in cancer. The drugs podophyllin and podophyllin pwdr and the compounds paraffin and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and cervix, and related mouse phenotypes are cellular and integument.

Wikipedia:63 Papilloma (plural papillomas or papillomata) (papillo- + -oma) refers to a benign epithelial tumor... more...

Aliases & Classifications for Papilloma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

papilloma 8 10 44 60
papillomatosis 8 44 60
papillomatosis, nos 8
papillomatosis nos 8


External Ids:

Disease Ontology8 DOID:2615
NCIt39 C7440
MeSH34 D010212

Related Diseases for Papilloma

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17GeneCards, 18GeneDecks
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Diseases related to Papilloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 439)
idRelated DiseaseScoreTop Affiliating Genes
1inverted papilloma31.6KRT13, KRT20, FSCN1, PCNA, CDKN1B, MKI67
2choroid plexus papilloma31.4CT49, S100B
3squamous cell carcinoma31.0TP53, TP63, ACTC1, KRT13, KRT20, RASSF1
4cervical cancer30.7TP53, RASSF1, FGFR3, CDKN1B, CDKN1A, CDKN2A
5bladder transitional cell papilloma30.6FGFR3
6papillary carcinoma30.6TP63, ACTC1, KRT20, CDKN1B, MKI67, IFI27
7bladder carcinoma30.5TP53, ACTC1, KRT20, RASSF1, FGFR3, CDKN1A
8transitional cell carcinoma30.5TP53, TP63, KRT20, FGFR3, PCNA, CDKN1A
9adenocarcinoma30.4TP53, TP63, ACTC1, KRT13, KRT20, RASSF1
10bladder transitional cell carcinoma30.3TP53, KRT20, MKI67, IFI27
11ductal carcinoma in situ30.2TP53
12adenoma30.2TP53, TP63, ACTC1, KRT13, KRT20, RASSF1
13breast cancer30.2TP53, TP63, LALBA, RASSF1, FSCN1, FGFR3
14cholangiocarcinoma30.2TP53, KRT20, RASSF1, CDKN1B
15retinoblastoma30.1TP53, RASSF1, FGFR3, PCNA, CDKN1B, CDKN1A
16laryngeal squamous cell carcinoma30.1TP53, TP63, PCNA, CDKN1A, CDKN2A, MKI67
17lichen planus30.1KRT13
18meningioma30.1PCNA, MKI67
19lung cancer30.0TP53, TP63, KRT20, FSCN1, PCNA, CDKN1A
20neuroendocrine carcinoma30.0TP63, KRT20, FSCN1, S100B
21keratoacanthoma30.0PCNA, CDKN1A, MKI67
22melanoma29.8TP53, TP63, ACTC1, RASSF1, FSCN1, FGFR3
23bladder carcinoma in situ29.8TP53, KRT20, RASSF1, FGFR3, PCNA, CDKN2A
24cervical squamous cell carcinoma29.8TP63, RASSF1, CDKN1B, CDKN1A, CDKN2A, MKI67
25hemangioma29.8ACTC1
26choroid plexus carcinoma29.8CT49, S100B
27seborrheic keratosis29.7FGFR3
28colorectal cancer29.6TP53, KRT20, RASSF1, FSCN1, FGFR3, PCNA
29astrocytoma29.6TP53, RASSF1, FSCN1, PCNA, CDKN1B, CDKN1A
30adenoid cystic carcinoma29.6TP63, ACTC1, KRT20, RASSF1, PCNA, MKI67
31non-small cell lung carcinoma29.6TP53, TP63, RASSF1, PCNA, CDKN1A, CDKN2A
32prostate cancer29.6TP63, PCNA, CDKN1B, CDKN1A, MKI67, CT49
33sarcoma29.6TP53, TP63, ACTC1, FSCN1, MKI67, S100B
34cervical adenocarcinoma29.6KRT20, RASSF1, CDKN1B, CDKN1A, CDKN2A, IFI27
35mucoepidermoid carcinoma29.6TP63, ACTC1, KRT13, PCNA, CDKN1B, MKI67
36lung small cell carcinoma29.6TP53, TP63, KRT20, RASSF1, CDKN2A, CT49
37medulloblastoma29.6TP53, ACTC1, RASSF1, CT49, S100B
38basal cell carcinoma29.6TP53, TP63, ACTC1, KRT20, MKI67
39leiomyoma29.6ACTC1, PCNA, MKI67, S100B
40synovial sarcoma29.6KRT13, RASSF1, MKI67, S100B
41papillary thyroid carcinoma29.6TP63, RASSF1, CT49, IFI27
42colon adenocarcinoma29.6KRT20, CDKN1B, CDKN1A
43endometrial carcinoma29.6TP53, RASSF1, CDKN2A, IFI27
44esophageal cancer29.6TP53, CDKN2A
45histiocytosis29.6FSCN1, S100B
46tongue cancer29.6CDKN1A
47adenocarcinoma in situ29.6CDKN2A
48endometriosis29.6ACTC1
49li-fraumeni syndrome29.6TP53, CDKN2A
50parathyroid adenoma29.6CDKN1B

Graphical network of the top 20 diseases related to Papilloma:



Diseases related to papilloma

Clinical Features for Papilloma

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Drugs & Therapeutics for Papilloma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Papilloma

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Anatomical Context for Papilloma

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32MalaCards
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MalaCards organs/tissues related to Papilloma:

32
Breast, Skin, Cervix, Bone, Lung, Testes, Salivary gland, Prostate, Endothelial, T cells, Tongue, Brain, Lymph node, Pineal, Kidney, Ovary, Thyroid, Pituitary, Trachea, Tonsil, Colon, Smooth muscle, Spinal cord, Liver, Temporal lobe

Animal Models for Papilloma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Papilloma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.4UBE3A, CDKN2A, CDKN1A, CDKN1B, PCNA, FGFR3
2MP:001077111.1TP53, S100B, UBE3A, CDKN2A, CDKN1A, CDKN1B
3MP:000538711.1CDKN1A, CDKN1B, PCNA, FGFR3, FSCN1, RASSF1
4MP:000200611.0CDKN2A, CDKN1A, CDKN1B, FGFR3, RASSF1, TP63
5MP:000537910.9UBE3A, CDKN2A, CDKN1A, CDKN1B, LALBA, TP53
6MP:000301210.9UBE3A, CDKN2A, CDKN1A, CDKN1B, PCNA, FGFR3
7MP:000538910.7UBE3A, CDKN2A, CDKN1A, CDKN1B, PCNA, FGFR3

Publications for Papilloma

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50PubMed
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Articles related to Papilloma:

(show top 50)    (show all 1496)
idTitleAuthorsYear
1
Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients. (22520573)
2013
2
TP53 mutation and human papilloma virus status of oral squamous cell carcinomas in young adult patients. (24112103)
2013
3
Choroid plexus papilloma arising in a mature cystic teratoma of a 32-year-old female. (23255035)
2013
4
High-risk human papilloma virus management in pregnancy with cervical intraepithelial neoplasia during pregnancy and postpartum in China. (24125014)
2013
5
Human papilloma virus lesions of the oral cavity: healing and relapse after treatment with 810-980A nm diode laser. (23942804)
2013
6
Chemotaxis of T-cells after infection of human choroid plexus papilloma cells with Echovirus 30 in an in vitro model of the blood-cerebrospinal fluid barrier. (23000117)
2012
7
Bilateral fungiform papilloma with synchronous verrucous carcinoma of the nasal septum: a rare presentation and a literature review. (22182527)
2012
8
Detection and quantification of bovine papilloma virus type 2 (BPV-2) by real-time PCR in urine and urinary bladder lesions in enzootic bovine haematuria (EBH)-affected cows. (21797988)
2012
9
Cutaneous papilloma and squamous cell carcinoma therapy utilizing nanosecond pulsed electric fields (nsPEF). (22937117)
2012
10
Human papilloma virus risk factors for infection and genotype distribution in aboriginal women from Northern Argentina. (23241287)
2012
11
Choroid plexus papilloma of the fourth ventricle in a septuagenarian. (23189015)
2012
12
Sequence variation analysis of the E2 gene of human papilloma virus type 16 in cervical lesions from women in Greece. (22294445)
2012
13
Bladder papilloma in a 9-year-old girl: a case report. (22555331)
2012
14
Tension pneumoventricle after resection of a fourth ventricle choroid plexus papilloma: An unusual postoperative complication. (23226603)
2012
15
Malignant sinonasal papilloma with neck metastasis: a rare report and literature review. (22057120)
2012
16
Low risk of contamination with human papilloma virus during treatment of condylomata acuminata with multilayer argon plasma coagulation and COa88 laser ablation. (21249502)
2011
17
Commentary on: Economic evaluation of human papilloma virus vaccination in the European Union: a critical review. (21387197)
2011
18
Dendritic cell subsets and immunological milieu in inflammatory human papilloma virus-related skin lesions. (21715145)
2011
19
Synchronous multicentric bilateral sinonasal inverted papilloma and frontal sinus osteoma. (21586960)
2011
20
Cellular expression of INK4a gene in cells of bladder cancer associated with human papilloma virus-16. (21113501)
2010
21
Cervical cancer risk perception and predictors of human papilloma virus vaccine acceptance among female university students in northern Nigeria. (21126130)
2010
22
A case-control study of the risk factors associated with sinonasal inverted papilloma. (20109321)
2010
23
Multiple dicentric chromosomes behind polyploidy in grade II atypical choroid plexus papilloma: a complementary cytogenetic evaluation. (19077039)
2009
24
Human papilloma virus type16 E6 deregulates CHK1 and sensitizes human fibroblasts to environmental carcinogens independently of its effect on p53. (19411857)
2009
25
Endoscopic management of malignant inverted papilloma of the nasopharynx. (19128692)
2008
26
The role of endoscopic surgery in the treatment of nasal inverted papilloma. (17505601)
2007
27
Prognostic implications of atypical histologic features in choroid plexus papilloma. (17086103)
2006
28
Urinary bladder carcinoma and human papilloma virus infection, an appraisal of risk. (16101338)
2005
29
2',5'-Oligoadenylate synthetase activity analysis and human papilloma virus typing as prognostic factors in patients with recurrent respiratory papillomatosis. (15550179)
2004
30
Presences of human papillomavirus DNA (HPV) and immunohistochemical p53 overexpression in papillomas of oral cavity. (15638389)
2004
31
Tailored endoscopic surgery for the treatment of sinonasal inverted papilloma. (14762883)
2004
32
Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression. (12566297)
2003
33
Human papillomavirus in conjunctival papilloma. (11423448)
2001
34
Lateral ventricle choroid plexus papilloma in childhood: management and complications. (11165613)
2000
35
Intracranial extension of inverted papilloma: An unusual and potentially fatal complication. (10562682)
1999
36
Breast imaging case of the day. Benign intraductal papilloma with focal atypical papillomatous hyperplasia. (9599399)
1998
37
Endoscopic resection of inverted papilloma of the nose and paranasal sinuses. (9850318)
1998
38
Intraductal papilloma as a cause of a parotid duct cyst. A case report. (8730370)
1996
39
Management of inverted papilloma. (7558813)
1995
40
Analysis of lectin receptors in normal nasal mucosa, nasal polyp, inverted papilloma and papillary adenocarcinoma. (15125275)
1993
41
Intraductal papilloma and papillomatosis. (1345385)
1992-1993
42
Choroid plexus papilloma. A new presentation of von Hippel-Lindau (VHL) disease. (1426409)
1992
43
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin papilloma by saponins. (1846234)
1991
44
Long-term response of recurrent respiratory papillomatosis to treatment with lymphoblastoid interferon alfa-N1. Papilloma Study Group. (1861694)
1991
45
Inverted papilloma of the penile urethra. (2265344)
1990
46
Conjunctival and canalicular papillomas and ichthyosis vulgaris. (3178078)
1988
47
The value of ductogalactography in the diagnosis of intraductal papilloma. (6665877)
1983
48
Unusual presentation of a choroid plexus papilloma. (1162590)
1975
49
Cerebrospinal fluid overproduction and hydrocephalus associated with choroid plexus papilloma. (4544345)
1974
50
Inverted papilloma of the nose and paranasal sinuses. (4831934)
1974

Genetic Variations for Papilloma

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Expression for genes affiliated with Papilloma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Papilloma

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Pathways for genes affiliated with Papilloma

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29KEGG, 53Reactome, 4Cell Signaling Technology, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 12EMD Millipore
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Pathways related to Papilloma according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0TP53, CDKN2A, CDKN1A, CDKN1B, FGFR3, FSCN1
210.9CDKN2A, CDKN1A, CDKN1B, FGFR3, RASSF1, TP53
3
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10.9FGFR3, CDKN1B, CDKN1A, UBE3A, S100B, IFI27
4
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10.9TP63, PCNA, CDKN1B, CDKN1A, CDKN2A, MKI67
510.8UBE3A, CDKN2A, CDKN1A, CDKN1B, TP53
6
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10.8CDKN2A, CDKN1A, CDKN1B, PCNA, TP53
710.8CDKN2A, CDKN1A, CDKN1B, PCNA, TP53
810.8TP53, FGFR3, CDKN1B, CDKN1A
910.8TP53, TP63, CDKN1A, CDKN2A
10
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10.8TP53, CDKN1B, CDKN1A, CDKN2A
11
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10.8CDKN2A, CDKN1A, CDKN1B, TP53
1210.8CDKN2A, CDKN1A, CDKN1B, TP53
13
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10.8TP53, CDKN1B, CDKN1A, CDKN2A
14
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10.8TP53, CDKN1B, CDKN1A, CDKN2A
15
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10.8S100B, CDKN1A, CDKN1B, FGFR3
1610.8CDKN1A, PCNA, TP63, TP53
17
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10.8TP53, PCNA, CDKN1B, CDKN1A
1810.8TP53, PCNA, CDKN1B, CDKN1A
19
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10.8CDKN1A, CDKN1B, PCNA, TP53
2010.8CDKN2A, CDKN1A, PCNA, TP53
21
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10.8PCNA, CDKN1B, CDKN1A, CDKN2A
22
Cell cycle Cell cycle (generic schema)
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10.8PCNA, CDKN1B, CDKN1A, CDKN2A
23
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10.7TP53, FGFR3, UBE3A
24
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10.7CDKN1A, FGFR3, TP53
25
Transcription P53 signaling pathway
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10.7TP53, CDKN1A, CDKN2A
2610.7CDKN1A, PCNA, TP53
2710.7TP53, PCNA, CDKN1A
28
Hide members
10.6TP63, TP53
2910.5CDKN1A

Compounds for genes affiliated with Papilloma

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Papilloma according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1paraffin4412.0CDKN1B, TP53, TP63, ACTC1, KRT13, KRT20
2retinoic acid44 2412.9S100B, CT49, MKI67, CDKN2A, CDKN1A, CDKN1B
3progesterone44 59 28 11 2415.8CDKN1A, LALBA, ACTC1, IFI27, S100B, CT49
4vegf4411.8IFI27, S100B, TP53, TP63, ACTC1, KRT20
5tyrosine4411.7S100B, IFI27, KRT20, TP63, ACTC1, LALBA
6doxorubicin44 49 1113.6TP53, TP63, FGFR3, CDKN1B, CDKN1A, CDKN2A
7testosterone44 59 11 2414.6PCNA, KRT20, ACTC1, TP63, CT49, CDKN1B
8arginine4411.6MKI67, TP53, TP63, PCNA, LALBA, FGFR3
9cisplatin44 49 59 1114.5CDKN2A, TP63, RASSF1, CDKN1A, MKI67, IFI27
10thymidine44 2412.5IFI27, TP53, TP63, PCNA, CDKN1B, CDKN1A
11oligonucleotide4411.5TP53, IFI27, CDKN2A, PCNA, CDKN1A, CDKN1B
12threonine4411.5CDKN1A, MKI67, S100B, CDKN2A, IFI27, RASSF1
13serine4411.4FSCN1, CDKN1A, CDKN1B, RASSF1, TP53, FGFR3
14hematoxylin4411.4KRT20, PCNA, MKI67, ACTC1, TP63, S100B
15bromodeoxyuridine4411.4S100B, IFI27, MKI67, CDKN1A, CDKN1B, PCNA
16steroid4411.4UBE3A, CT49, IFI27, CDKN2A, ACTC1, LALBA
17paclitaxel44 49 1113.3S100B, TP53, CDKN1A, CDKN2A, IFI27, CDKN1B
18cytarabine44 49 1113.3IFI27, CDKN2A, CDKN1B, PCNA, CDKN1A, TP53
19p0034411.3RASSF1, S100B, IFI27, MKI67, CDKN1B, TP63
20thymidylate4411.3IFI27, PCNA, TP53, CDKN2A, CDKN1A, MKI67
21mg 13244 5912.3TP53, PCNA, CDKN1B, CDKN2A, IFI27, CDKN1A
22formaldehyde44 2412.3S100B, MKI67, PCNA, KRT20, ACTC1, CDKN1B
235-aza-2deoxycytidine4411.3CDKN2A, PCNA, CT49, CDKN1A, RASSF1, TP53
24alanine4411.3S100B, PCNA, CDKN2A, CT49, RASSF1, UBE3A
25b 7234411.2KRT20, ACTC1, S100B, TP63, PCNA
265fluorouracil4411.2TP53, CDKN2A, PCNA, MKI67, CDKN1B, CDKN1A
27roscovitine4411.2CDKN2A, IFI27, TP53, PCNA, CDKN1A
28n acetylcysteine4411.2TP53, CDKN1A, IFI27, PCNA, CDKN1B, CDKN2A
29tamoxifen44 49 28 1114.2PCNA, IFI27, TP53, MKI67, CDKN1A, CDKN1B
30hpvs4411.2CDKN1A, TP53, UBE3A, CDKN2A
31mucicarmine4411.1ACTC1, S100B, TP63, KRT20
32olomoucine44 1112.1CDKN2A, PCNA, TP53, CDKN1A
33temozolomide44 1112.1TP53, PCNA, CDKN1A, CDKN2A
34troglitazone44 28 59 1114.1KRT20, CDKN1B, CDKN1A, IFI27, KRT13
35o6-methylguanine4411.1PCNA, TP53, CDKN2A, RASSF1
36eb 108944 5912.1IFI27, CDKN1A, CDKN1B, PCNA
37aphidicolin4411.1PCNA, CDKN1A, CDKN1B, TP53
38camptothecin44 59 1113.1CDKN2A, TP53, PCNA, CDKN1B, CDKN1A
39indole-3-carbinol4411.1TP53, CDKN1A, IFI27, CDKN1B
40sulindac44 1112.0CDKN1A, TP53, PCNA, IFI27
41estrogen4411.0LALBA
42imatinib44 49 1113.0ACTC1, S100B, CDKN1A, CDKN1B, FGFR3
43methanol44 2412.0LALBA, ACTC1, CDKN2A, MKI67
44acnu4410.9TP53, CDKN1A, CDKN2A
45flavopiridol44 1111.8CDKN1B, CDKN2A, CDKN1A, TP53
46norcantharidin4410.8IFI27, PCNA, MKI67
47celecoxib44 59 28 49 11 2415.8CDKN1A, CDKN1B, PCNA, MKI67
482-methoxyethanol4410.7TP63, ACTC1, UBE3A
49reticulin4410.6S100B, ACTC1, PCNA
50dexamethasone44 49 28 1113.5IFI27, CDKN2A, PCNA, S100B, CDKN1B

GO Terms for genes affiliated with Papilloma

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16Gene Ontology
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Cellular components related to Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.0S100B, UBE3A, MKI67, CDKN2A, CDKN1B, PCNA
2nucleoplasmGO:00565410.9CDKN1A, CDKN1B, PCNA, TP63, TP53, CDKN2A
3PCNA-p21 complexGO:07055710.5PCNA, CDKN1A

Biological processes related to Papilloma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cell cycle arrestGO:00705011.1TP53, RASSF1, CDKN1B, CDKN1A, CDKN2A
2Ras protein signal transductionGO:00726511.0TP53, RASSF1, CDKN1A, CDKN2A
3cell proliferationGO:00828311.0S100B, MKI67, PCNA, FSCN1, TP53
4negative regulation of cell growthGO:03030811.0CDKN2A, CDKN1A, CDKN1B, TP53
5mitotic cell cycle arrestGO:07185011.0CDKN1A, CDKN1B, TP53
6phosphatidylinositol-mediated signalingGO:04801511.0CDKN1A, CDKN1B, PCNA, FGFR3
7negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:04573610.9CDKN2A, CDKN1A, CDKN1B
8negative regulation of phosphorylationGO:04232610.9CDKN1B, CDKN1A, CDKN2A
9negative regulation of apoptotic processGO:04306610.9CDKN1A, CDKN1B, FGFR3, TP63, TP53
10DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00697710.8TP53, CDKN1B, CDKN1A
11G1/S transition of mitotic cell cycleGO:00008210.7PCNA
12activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.7CDKN1B, CDKN2A, IFI27
13DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.6TP53, TP63
14mitotic G1 DNA damage checkpointGO:03157110.5TP63, TP53
15replicative senescenceGO:09039910.3TP53, CDKN2A

Molecular functions related to Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.1S100B, UBE3A, MKI67, CDKN2A, CDKN1A, CDKN1B
2identical protein bindingGO:04280210.8TP53, TP63, RASSF1, PCNA, S100B
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.8CDKN1B, CDKN1A, CDKN2A
4MDM2/MDM4 family protein bindingGO:09737110.6TP53, CDKN2A
5p53 bindingGO:00203910.6CDKN2A, TP63, TP53

Products for genes affiliated with Papilloma

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Sources for Papilloma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet