Papilloma malady

Disease Ontology: A cell type benign neoplam that is composed of epithelial tissue on papillae of vascularized connective tissue.⁶

MalaCards: Papilloma, also known as papillomatosis, is related to inverted papilloma and choroid plexus papilloma. An important gene associated with Papilloma is UBE3A (ubiquitin protein ligase E3A), and among its related pathways are Pancreatic cancer and Non-small cell lung cancer. The drugs podophyllin and podophyllin pwdr [va product] and the compounds retinoic acid and calcium have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and lung, and related mouse phenotypes are normal and mortality/aging.

Wikipedia: The word papilloma, according to dermatologists, is synonymous with what some people call skin tags....⁴⁴ more...

Aliases & Descriptions:

papilloma 6 8 32 43 papillomatosis 6 8 32 43 papilloma (except papilloma of bladder m-81201) (morphologic abnormality) 6

papillomatosis nos (morphologic abnormality) 6 papillomatosis, nos 6

Diseases related to papilloma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 971)

id	Related Disease	Score	Top Affiliating Genes
1	inverted papilloma	35.9	PCNA, FSCN1, CDKN1B, MKI67, IFI27, KRT13
2	choroid plexus papilloma	35.2	MUC1, S100B, IGF2, GFAP, TTR, TAG
3	bladder transitional cell papilloma	33.8	BIRC5, PARP1, CDKN1A, FGFR3, CASP2, TP53
4	skin papilloma	33.6	VEGFA, CHUK, LALBA, HTR1E, TP53, SP8
5	intraductal papilloma	33.2	TP63, PRKG1, MYH11
6	squamous cell carcinoma	32.9	SERPINB3, PAK1, CD44, MKI67, CCND1, DAPK1
7	choroiditis	30.9	PCNA, VIM, BRAF, VEGFA, RARB, RASSF1
8	recurrent respiratory papillomatosis	29.1	CDKN1A, CDKN2A, IFNA2, ESR1, ERBB2, TP53
9	keratosis	29.1	PCNA, RB1, BCL2, S100B, CDKN1A, CDKN2B
10	cervical intraepithelial neoplasia	28.7	PCNA, RB1, VEGFA, BIRC5, BCL2, YY1
11	verrucous carcinoma	28.3	PCNA, RB1, CDKN1A, CDKN2A, CD44, CCND1
12	meningioma	28.3	PCNA, MKI67, ESR1, PGR
13	amelanotic melanoma	27.9	PARP1, S100A1, S100B, CYCS, TYR
14	sleep apnea	27.9	RET, PCNA, S100B, MSX2, FGFR3, IGF2
15	apnea	27.7	RET, PCNA, BAX, S100B, MSX2, FGFR3
16	follicular adenoma	27.6	RET, BIRC5, MKI67, MEN1, PTEN, STAT3
17	neurofibromatosis	27.3	RET, BRCA2, S100B, MEN1, NF1, KRT14
18	parathyroid adenoma	27.1	RET, PCNA, BCL2, CDK6, CDKN2B, CDKN1B
19	ependymoma	27.1	RB1, VIM, BRCA2, VEGFA, RARB, RASSF1
20	leukoplakia	26.9	PCNA, RARA, RARB, BCL2, BAX, CDKN1B
21	laryngeal squamous cell carcinoma	26.8	PCNA, RB1, VEGFA, BIRC5, BCL2, BAX
22	primary hyperparathyroidism	26.7	RET, BRCA2, CD36, CDKN1B, MEN1, CCND1
23	endocervicitis	26.4	VIM, BCL2, MUC1, CDK6, CDKN1A, CDKN2A
24	chronic mucocutaneous candidiasis	26.3	IL17D, IL2, IFNB1, IFNG, STAT1
25	laryngitis	26.3	PCNA, RB1, SERPINB3, SERPINB2, VIM, BRCA2
26	sinusitis	26.2	PCNA, SERPINB3, VIM, VEGFA, BIRC5, MUC1
27	immunodeficiency	26.1	PARP1, PARK2, PADI4, CD4, CD1A, FOXP3
28	li-fraumeni syndrome	26.1	BRCA2, FHIT, IGF2, IGFBP3, ESR1, ERBB2
29	pemphigus vulgaris	26.1	IVL, IL2, IFNG, HLA-B, HLA-G, EGF
30	cervicitis	25.9	PIN1, RET, PCNA, RB1, SERPINB3, SERPINB2
31	hemophilia	25.6	CD4, GUSB, IFNA2, IFNG, F9, HLA-B
32	squamous cell carcinoma of the head and neck	25.6	RB1, VEGFA, RARA, RARB, RASSF1, BIRC5
33	hemangioma	25.5	RET, RB1, VEGFA, MUC1, CDKN2A, FOXM1
34	hyperparathyroidism	25.5	RET, PCNA, BRCA2, VEGFA, BAX, CDKN1A
35	schistosomiasis	25.3	RB1, BCL2, CDKN1A, CDKN2B, CDKN2A, CD4
36	neutropenia	25.2	BIRC5, BCL2, S100B, GUSB, IFNA2, IFNB1
37	cervical cancer	25.1	PIN1, PCNA, RB1, SERPINB3, BRAF, BRCA2
38	pemphigus	24.9	BAX, JUN, IVL, IL2, IFNA2, IFNG
39	laryngeal carcinoma	24.8	PCNA, RB1, SERPINB2, VEGFA, RASSF1, BIRC5
40	vaccinia	24.5	CHUK, YY1, MUC1, UBE2B, BAK1, BAX
41	endometrial adenocarcinoma	24.3	PCNA, RB1, SERPINB2, VIM, BRAF, VEGFA
42	ductal carcinoma in situ	24.3	PCNA, RB1, VIM, BRCA2, VEGFA, RARA
43	cervical carcinoma	23.9	PCNA, RB1, SERPINB3, VIM, VEGFA, RARB
44	oral squamous cell carcinoma	23.8	PIN1, PCNA, RB1, SERPINB3, VIM, BRAF
45	carcinoma	23.0	PIN1, RET, PCNA, RB1, SERPINB3, SERPINB2
46	insulin resistance	22.7	VEGFA, RAC1, CHUK, JUN, CD36, FOS
47	breast cancer	22.6	BRCA2, VEGFA, BCL2, XRCC5, MMP2, AR
48	retinoblastoma	22.5	PCNA, RB1, SERPINB2, VIM, BRCA2, VEGFA
49	obesity	22.3	PCNA, VEGFA, RARA, RARB, RAC1, PARK2
50	esophagitis	22.1	PIN1, RET, PCNA, RB1, SERPINB3, SERPINB2

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 podophyllin, podophyllin pwdr [va product]

MalaCards organs/tissues related to papilloma:

²²

MGI Mouse Phenotypes related to papilloma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal phenotype	MP:0002873	INF	RET, BRAF, BRCA2, VEGFA, RARA, RARB
2	mortality/aging	MP:0010768	INF	RET, RB1, SERPINB2, BRAF, BRCA2, VEGFA
3	integument phenotype	MP:0010771	INF	PIN1, RB1, BRAF, BRCA2, RAC1, CLDN7
4	craniofacial phenotype	MP:0005382	INF	BMP5, MSX2, FOXP3, FLG, GUSB, MEN1
5	digestive/alimentary phenotype	MP:0005381	INF	RET, RB1, BRAF, BRCA2, VEGFA, BMP5
6	limbs/digits/tail phenotype	MP:0005371	INF	RET, RB1, BRCA2, VEGFA, BMP5, RARA
7	respiratory system phenotype	MP:0005388	9.8	RET, BMP5, PARK2, YY1, TP63, DMD
8	hearing/vestibular/ear phenotype	MP:0005377	9.3	RB1, BMP5, RARA, RARB, CLDN11, PARP1
9	pigmentation phenotype	MP:0001186	9.2	RB1, BRAF, RAC1, BCL2, MSX2, CDKN1B
10	hematopoietic system phenotype	MP:0005397	9.1	PCNA, SERPINB2, BRAF, BRCA2, CLDN7, BCL2
11	other phenotype	MP:0005395	8.7	RARA, RARB, CDKN2A, IL2, CAV1, PTGS2
12	endocrine/exocrine gland phenotype	MP:0005379	8.7	RET, BRCA2, BMP5, LALBA, MSX2, CDK6
13	liver/biliary system phenotype	MP:0005370	8.5	VEGFA, BMP5, CD36, FOXM1, AR, MEN1
14	renal/urinary system phenotype	MP:0005367	8.0	RET, BRAF, BMP5, RARA, RARB, CLDN7
15	vision/eye phenotype	MP:0005391	7.3	PIN1, RB1, VIM, BRAF, VEGFA, RARA
16	adipose tissue phenotype	MP:0005375	7.3	RB1, BRAF, BCL2, CDKN1A, CD36, CDKN1B
17	reproductive system phenotype	MP:0005389	7.2	RET, BRCA2, VEGFA, RARA, RARB, CLDN11
18	immune system phenotype	MP:0005387	7.0	SERPINB2, VIM, BRAF, BRCA2, BMP5, RARA
19	tumorigenesis	MP:0002006	6.3	RET, RB1, BRAF, BRCA2, RARA, RASSF1
20	muscle phenotype	MP:0005369	6.2	RET, RB1, SERPINB2, VIM, BRAF, VEGFA
21	cardiovascular system phenotype	MP:0005385	4.7	RET, RB1, VIM, BRAF, VEGFA, BMP5
22	cellular phenotype	MP:0005384	3.5	PIN1, RET, PCNA, RB1, VIM, BRAF
23	homeostasis/metabolism phenotype	MP:0005376	3.3	RET, RB1, SERPINB2, VIM, BRAF, BRCA2
24	nervous system phenotype	MP:0003631	INF	RB1, BRAF, RARA, RAC1, CLDN11, PARP1
25	no phenotypic analysis	MP:0003012	INF	RET, PCNA, RB1, VEGFA, PARP1, MUC1
26	skeleton phenotype	MP:0005390	INF	RB1, BRAF, BRCA2, VEGFA, RARA, RARB
27	growth/size phenotype	MP:0005378	INF	PIN1, RET, RB1, SERPINB2, BRAF, BRCA2
28	behavior/neurological phenotype	MP:0005386	INF	RB1, VIM, BRAF, BRCA2, BMP5, RARB
29	embryogenesis phenotype	MP:0005380	INF	RET, VIM, BRAF, BRCA2, BMP5, RARB

Articles related to papilloma:

(show top 50)    (show all 212)

id	Title	Authors	Year	Affiliating Genes
1	Intraductal papilloma of ectopic breast tissue in axi llary lymph node of a patient with a previous intraductal papilloma of ipsilate ral breast: a case report and review of the literature. (20222992)	Dzodic R.... Yamashita S.	2010	TP63
2	Cellular factor YY1 downregulates the human papilloma virus 16 E6/E7 promoter, P97, in vivo and in vitro from a negative element over lapping the transcription-initiation site. (19553391)	Lace M.J.... Turek L.P.	2009	YY1
3	The expression of PTEN and P16 protein in nasal inve rted papilloma]. (19522184)	Zhao J.... Kong W.	2009	PTEN, CDKN2A
4	FGFR3 and TP53 mutation analysis in inverted urothelial papilloma: incidence and etiological considerations. (19287463)	Lott S.... Cheng L.	2009	FGFR3, TP53
5	Prevalence and significance of antibodies to citrullinated human papilloma virus-47 E2345-362 in rheumatoid arthritis. (18511237)	Shi J.... Li Z.	2008	PADI4
6	Ubiquitin-dependent proteolysis of trihydrophobin 1 (TH1) by the human papilloma virus E6-associated protein (E6-AP). (17131388)	Yang Y.... Gu J.	2007	TP53, UBE3A, PARK2
7	Urothelial carcinoma with an inverted growth pattern can be distinguished from inverted papilloma by fluorescence in situ hybridization, immunohistochemistry, and morphologic analysis. (18043040)	Jones T.D.... Cheng L.	2007	MKI67, KRT20
8	Prognostic significance of TP53 mutations in oral squamous cell carcinoma with human papilloma virus infection. (18161655)	Kozomara R.J.... Magic Z.M.	2007	TP53
9	The expression of p16 (INK4a) and Ki-67 in relation to high-risk human papilloma viral load and residual disease after conization with positive margins. (17367326)	Song S.H.... Saw H.S.	2007	CDKN2A
10	Up-regulation of Rac1 by epidermal growth factor mediates COX-2 expression in recurrent respiratory papillomas. (17592548)	Wu R.... Steinberg B.M.	2007	PTGS2
11	Increased expression of matrix metalloproteinase-2 and 9 and human papilloma virus infection are associated with malignant transformation of sinonasal inverted papilloma. (16353190)	Katori H.... Tsukuda M.	2006	MMP2
12	Histological features of human papilloma virus 16 and its association with the development and progression of anal squamous cell car cinoma. (16998682)	Kagawa R.... Furuta R.	2006	DMD
13	The expression of epidermal growth factor receptor, vascular endothelial growth factor, matrix metalloproteinase-2, and cyclooxygenase-2 in relation to human papilloma viral load and persistence of human papillomavirus after conization with negative margins. (17177839)	Song S.H.... Park Y.K.	2006	EGFR, MMP2, PTGS2
14	Relationship between p21 and p53 expression, human papilloma virus infection and malignant transformation in sinonasal-inverted papilloma. (16703747)	Katori H.... Tsukuda M.	2006	TP53, CDKN1A
15	Expression of human papilloma virus (HPV) and P16ink4a in cervical intraepithelial neoplasia (CIN) and papilloma (16637315)	Vasilev I.... Stoianov S.	2006	CDKN2A
16	The use of mitomycin-C for respiratory papillomas: cl inical, histologic and biochemical correlation. (16311658)	Hamza A.H.... Deghady A.A.	2005	IL2
17	Immunohistochemical evaluation of intermediate filament proteins in squamous papilloma and oral verrucous carcinoma. (16120114)	Oliveira M.C.... Queiroz L.M.	2005	KRT10
18	Epidermal growth factor-induced cyclooxygenase-2 expression is mediated through phosphatidylinositol-3 kinase, not mitogen-activated protein/extracellular signal-regulated kinase kinase, in recurrent respiratory papillomas. (16144915)	Wu R.... Steinberg B.M.	2005	EGFR
19	Correlation p53 expression and human papilloma virus deoxyribonucleic acid with clinical outcome in early uterine cervical carcinoma. (16289387)	Ikuta A.... Kanzaki H.	2005	TP53
20	Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid. (15215482)	Gustafsson L.... Svanborg C.	2004	LALBA
21	Re: Distinction of endocervical and endometrial adenocarcinomas: immunohistochemical p16 expression correlated with human papilloma virus (HPV) DNA detection. (15223971)	McCluggage W.G.	2004	CDKN2A
22	Presences of human papillomavirus DNA (HPV) and immunohistochemical p53 overexpression in papillomas of oral cavity. (15638389)	Barzal/-Nowosielska M.... Chyczewski L.	2004	TP53
23	Simultaneous human papilloma virus type 16 E7 and cdk inhibitor p21 expression induces apoptosis and cathepsin B activation. (15016552)	Kaznelson D.W.... Norrild B.	2004	CTSB, CDKN1A
24	UV-vulnerability of human papilloma virus type-16 E7-expressing astrocytes is associated with mitochondrial membrane depolarization and caspase-3 activation. (12442903)	Lee W.T.... Lee J.E.	2002	TP53
25	Study of CD44v6 protein expression in intraductal papilloma and its malignant transformation of breast (12452061)	He J.H.... Xiao Y.B.	2002	CD44
26	Human papilloma virus and p53 expression in carcinomas associated with sinonasal papillomas: a Danish Epidemiological study 1980-1998. (11404629)	Buchwald C.... Franzmann M.B.	2001	TP53
27	Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia. (11420459)	Keating J.T.... Crum C.P.	2001	CDKN2A, MKI67
28	Feedback regulation between orphan nuclear receptor TR2 and human papilloma virus type 16. (11358973)	Collins L.L.... Chang C.	2001	NR2C1
29	Human papilloma virus infection and expression of p16 protein in laryngeal papilloma and laryngeal carcinoma (12761910)	Li J.... Zhou A.	2001	CDKN2A
30	Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation. (11076533)	Razani B.... Lisanti M.P.	2000	CAV1
31	Expression of human papilloma virus E7 protein causes apoptosis and inhibits DNA synthesis in primary hepatocytes via increased expression of p21(Cip-1/WAF1/MDA6). (10617580)	Park J.S.... Dent P.	2000	CDKN1A
32	The Brn-3a transcription factor plays a critical role in regulating human papilloma virus gene expression and determining the growth characteristics of cervical cancer cells. (10497216)	Ndisang D.... Latchman D.S.	1999	POU4F1
33	Prevalence of human papilloma virus DNA in head and neck cancers carrying wild-type or mutant p53 tumor suppressor genes. (10226517)	Adams V.... SchAofer R.	1999	TP53, RPS27A
34	12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mouse epidermis coexpressing transforming growth factor-alpha and v-fos: acceleration of autonomous papilloma formation and malignant conversion via c-Ha-ras activation. (10569807)	Wang X.J.... Roop D.R.	1999	TP53, FOS, TGFA
35	Immunocytochemical detection of insulin-like growth factor II (IGF-II) in choroid plexus papilloma: a possible marker for differential diagnosis. (10192701)	Kubo S.... Hasegawa H.	1999	IGF2
36	Expression of cytokeratin 20 redefines urothelial papillomas of the bladder. (10459907)	Harnden P.... Southgate J.	1999	KRT20
37	Elevation of the epidermal growth factor receptor and dependent signaling in human papillomavirus-infected laryngeal papillomas. (10029092)	Johnston D.... Steinberg B.M.	1999	EGFR
38	Characterisation of X;17(q12;p13) translocation breakpoints in a female patient with hypomelanosis of Ito and choroid plexus papilloma. (9195154)	Zajac V.... Monaco A.P.	1997	SHBG
39	High-risk HPV types in oral and laryngeal papilloma and leukoplakia (9213402)	Arndt O.... Brock J.	1997	SLPI
40	ERC-55, a binding protein for the papilloma virus E6 oncoprotein, specifically interacts with vitamin D receptor among nuclear receptors. (9168930)	Imai T.... Kato S.	1997	NR1H2
41	Human papilloma viruses and p53 mutations in normal pre-malignant and malignant oral epithelia. (8608985)	Mao E.J.... Beckmann A.M.	1996	TP53
42	Malignant inverted papilloma of the urinary bladder: the histopathological aspect of malignant potential of inverted papilloma. (7576290)	Cheon J.... Kim I.S.	1995	PCNA
43	Immunohistochemical localization of the glucose transporter GLUT1 in choroid plexus papillomas. (7795732)	Kurosaki M.... Hirano H.	1995	SLC2A1
44	Inverted ductal papilloma of minor salivary gland origin: morphological aspects and cytokeratin expression. (8679158)	de Sousa S.O.... de AraA_jo V.C.	1995	KRT7, KRT13
45	Differential regulation by c-jun and c-fos protooncogenes of hormone response from composite glucocorticoid response element in human papilloma virus type 16 regulatory region. (7708058)	Mittal R.... Pater M.M.	1994	JUN
46	Interferon treatment enhances the expression of underphosphorylated (biologically-active) retinoblastoma protein in human papilloma virus-infected cells through the inhibitory TGF beta 1/IFN beta cytokine pathway. (7511881)	Arany I.... Tyring S.K.	1994	TGFB1, IFNB1
47	Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas. (8117621)	Dominey A.M.... Greenhalgh D.A.	1993	TGFA
48	Transactivation of the human papilloma virus 16 octamer motif by the octamer binding protein Oct-2 requires both the N and C terminal activation domains. (8233784)	Morris P.J.... Latchman D.S.	1993	POU2F2
49	The status of the p53 gene in human papilloma virus positive or negative cervical carcinoma cell lines. (1322252)	Srivastava S.... Chang E.H.	1992	TP53
50	Evaluation of the usefulness of analysis of beta-glucuronidase levels in patients with superficial cancer and papilloma of the bladder (1480522)	Rokicki M.... Fryczkowski M.	1992	GUSB

Genes related to papilloma according to GeneCards:

(show top 50)    (show all 173)

id	Symbol	Description	Score	GeneCards Section Context
1	UBE3A	ubiquitin protein ligase E3A	11.0	Orthologs, Aliases & Descriptions, Publications, Functions
2	HPV18I1	human papilloma virus (type 18) integration site 1	11.0	Functions, Aliases & Descriptions
3	SIPA1L1	signal-induced proliferation-associated 1 like 1	11.0	Aliases & Descriptions
4	TP53	tumor protein p53	11.0	Publications
5	KRT13	keratin 13	11.0	Publications
6	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
7	TP63	tumor protein p63	11.0	Publications
8	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	11.0	Publications
9	LALBA	lactalbumin, alpha-	11.0	Publications
10	KRT20	keratin 20	11.0	Publications
11	FGFR3	fibroblast growth factor receptor 3	11.0	Publications
12	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
13	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
14	PCNA	proliferating cell nuclear antigen	11.0	Publications
15	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	11.0	Publications
16	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
17	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0	Publications
18	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0	Publications
19	MYH11	myosin, heavy chain 11, smooth muscle	11.0	Publications
20	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
21	TTR	transthyretin	11.0	Publications
22	CD44	CD44 molecule (Indian blood group)	11.0	Publications
23	GFAP	glial fibrillary acidic protein	11.0	Publications
24	S100B	S100 calcium binding protein B	11.0	Publications
25	TGFA	transforming growth factor, alpha	11.0	Publications
26	MUC1	mucin 1, cell surface associated	11.0	Publications
27	RB1	retinoblastoma 1	11.0	Publications
28	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Publications
29	PRKG1	protein kinase, cGMP-dependent, type I	11.0	Publications
30	KRTAP11-1	keratin associated protein 11-1	11.0
31	ZMYND10	zinc finger, MYND-type containing 10	11.0	Publications
32	SP8	Sp8 transcription factor	11.0
33	POU4F1	POU class 4 homeobox 1	11.0	Publications
34	CLDN11	claudin 11	11.0
35	SERPINB3	serpin peptidase inhibitor, clade B (ovalbumin), member 3	11.0	Publications
36	CSTA	cystatin A (stefin A)	11.0	Publications
37	KRT10	keratin 10	11.0	Publications
38	CCNG1	cyclin G1	11.0	Publications
39	UBE2B	ubiquitin-conjugating enzyme E2B	11.0	Publications
40	CTSS	cathepsin S	11.0	Publications
41	MSX2	msh homeobox 2	11.0	Publications
42	DSG3	desmoglein 3	11.0	Publications
43	UQCC	ubiquinol-cytochrome c reductase complex chaperone	11.0	Publications
44	KRT14	keratin 14	11.0	Publications
45	CDX2	caudal type homeobox 2	11.0	Publications
46	KRT7	keratin 7	11.0	Publications
47	IVL	involucrin	11.0	Publications
48	TOP2A	topoisomerase (DNA) II alpha 170kDa	11.0	Publications
49	CASP2	caspase 2, apoptosis-related cysteine peptidase	11.0	Publications
50	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	11.0	Publications

Pathways related to papilloma according to GeneDecks:

(show top 50)    (show all 230)

id	Pathway	Score	Top Affiliating Genes
1	Pancreatic cancer20	10.8	CDK6, BRCA2
2	Non-small cell lung cancer20	10.6	TGFA, EGF, ERBB2, FHIT, CDKN2A, CDK6
3	Glioblastoma Multiforme36	10.5	EGFR, NF1, PTEN, RB1, BRAF, RAC1
4	G1-S Phase Transition36	10.4	CCND1, CCNE2, CDKN2A, CDKN1B, CDKN2B, CDKN1A
5	Bladder cancer20	10.4	FGFR3, CCND1, MMP2, CDKN2A, RB1, BRAF
6	Glioma20	10.3	EGF, PTEN, TP53, CCND1, CDK6, EGFR
7	Small cell lung cancer20	10.2	BCL2, RARB, RB1, CHUK, CDK6, CDKN2B
8	Apoptosis Signaling Pathways37	10.2	BAK1, CYCS, CASP3, BIRC5, BCL2, TP53
9	Colorectal cancer20	10.2	BRAF, TGFB1, FOS, RAC1
10	Hepatitis C20	10.2	IFNA2, BRAF, CLDN1, CLDN11, CHUK, CDKN1A
11	all-trans-Retinoic Acid Mediated Apoptosis36	10.2	CRABP2, RARB, RARA, FADD, IFNA2, IFNB1
12	Cell Cycle / Checkpoint Control3	10.1	FOXM1, FOS, CCND1, CHEK1, BRCA2, RB1
13	Cyclins and Cell Cycle Regulation36	10.1	TGFB1, TP53, CCND1, CDKN2A, CDKN1B, CCNE2
14	ErbB2-ErbB3 Heterodimers36	10.1	PRKCE, STAT2, ERBB2, STAT1
15	Breast Cancer Regulation by Stathmin136	10.1	RAC1, PAK1, EGFR, EGF, ERBB2, CCNG1
16	Apoptosis through Death Receptors36	10.0	CHUK, CASP3, BAX, CYCS, DAPK1, TP53
17	Prostate cancer20	10.0	TGFA, CDKN1B, AR, CCNE2, CCND1, ERBB2
18	Apoptotic Pathways Triggered By HIV136	9.9	CYCS, TP53, CASP3, FADD, CD4, BAX
19	ILK Signaling36	9.8	TGFA, MYH11, PXN, VIM, TIMP2, EGFR
20	Fas Signaling36	9.8	CASP2, RB1, CASP3, JUN, FADD, CASP8
21	p53 Signaling36	9.7	BCL2, CDKN1A, PTEN, TP53, BAX, CASP8
22	TNFR1 Pathway36	9.7	PAK1, PAK2, CHUK, JUN, CASP2, CASP8
23	Akt Signaling36	9.7	BMP5, CHUK, CD4, CSF2, CCND1, CHEK1
24	Apoptosis and survival_FAS signaling cascades41	9.6	CASP8, CYCS, PARP1, PAK2, BCL2, BAX
25	p53 signaling pathway20	9.6	CCNE2, CASP3, IGFBP3, CASP8, CCND1, CDKN2A
26	Development_EGFR signaling pathway41	9.5	TGFA, EGFR, STAT1, PRKCE, FOS, ERBB2
27	DHA Signaling36	9.5	TGFB1, IL2, TGFA, TIMP2, EGFR, EGF
28	Apoptosis and survival FAS signaling cascades10	9.4	CASP8, CASP2, CASP3, FADD, BAX, BCL2
29	p53 Mediated Apoptosis36	9.4	TIMP2, TGFA, BCL2, BMP5, IL2, IGF2
30	Cellular Apoptosis Pathway36	9.4	BMP5, BCL2, EGFR, EGF, CYCS, TP53
31	Mitochondrial Apoptosis36	9.3	FGFR3, IL2, FADD, IGF2, CASP3, CASP8
32	EGF Pathway36	9.3	STAT3, PRKCE, STAT1, PXN, EGFR, EGF
33	Endothelin-1 Signaling Pathway36	9.3	EGFR, BRAF, FGFR3, IL2, CASP3, CASP2
34	JNK Pathway36	9.3	CD4, JUN, BAX, BCL2, BMP5, RAC1
35	Cell cycle_ESR1 regulation of G1/S transition41	9.2	ESR1, CCND1, FOS, CDKN1B, CDKN1A, CDK6
36	PAK Pathway36	9.1	EGFR, TIMP2, TGFA, TGFB1, PXN, CSF2
37	Pancreatic Adenocarcinoma36	9.1	RB1, CCNG1, IGF2, ERBB2, TP53, PTGS2
38	Measles20	9.1	STAT2, STAT3, STAT1, TYK2, EIF2AK4, CDKN1B
39	Colorectal Cancer Metastasis36	8.8	TGFB1, CDKN1A, CCND1, BRAF, BIRC5, BAX
40	Renin-Angiotensin Pathway36	8.7	EGFR, TYK2, TIMP2, TGFA, TGFB1, STAT1
41	Antioxidant Action of Vitamin-C36	8.7	RAC1, BCL2, CHUK, BAX, JUN, CD4
42	MAPK Family Pathway36	8.7	BCL2, PAK2, PAK1, RAC1, TGFA, BRAF
43	Tec Kinases Signaling36	8.6	IGF2, RAC1, IL2, FGFR3, FOS, CD4
44	MAPK Signaling36	8.6	TIMP2, TGFA, BRAF, BMP5, RAC1, PAK1
45	GPCR Pathway36	8.6	IL2, BMP5, BRAF, JUN, RAC1, PAK1
46	ERK Signaling36	8.5	TGFA, PAK2, CHUK, FGFR3, IL2, IGF2
47	Molecular Mechanisms of Cancer36	8.3	FADD, IL2, FOS, CD4, CDKN2A, CDKN1B
48	Pathways in cancer20	8.3	SLC2A1, STAT3, TGFB1, TGFA, EGFR, EGF
49	Estrogen Pathway36	8.2	IGF2, IL2, FGFR3, FOS, UBE3A, CHUK
50	JAK-STAT Pathway36	8.0	JUN, CD4, FOS, FGFR3, IL2, IGF2

Compounds related to papilloma according to GeneDecks:

(show top 50)    (show all 443)

id	Compound	Score	Top Affiliating Genes
1	retinoic acid32 42 18	INF	RET, RB1, SERPINB2, BRAF, BRCA2, RARA
2	calcium32 9 18 9	INF	PIN1, RB1, SERPINB2, BRAF, RARA, RAC1
3	genistein32 9 18 9	INF	RET, PCNA, RB1, VIM, BRCA2, VEGFA
4	sp 60012532 42	11.6	PAK2, CDKN1A, CASP3, TP53, CYCS
5	phosphatidylserine32 9 9	12.4	VIM, RAC1, PARP1, PAK2, BCL2, BAK1
6	methionine32	10.4	RET, SERPINB2, VIM, RASSF1, LALBA, S100B
7	4-hydroxytamoxifen32	10.0	BRCA2, PARP1, S100B, JUN, ERBB2, NR1H2
8	temozolomide32 9 9	12.0	PCNA, VIM, VEGFA, PARP1, CHEK1, CDKN1A
9	irinotecan32 34 9 9	12.9	BRAF, VEGFA, PARP1, CHEK1, BAK1, BAX
10	trastuzumab32 34 9 9	12.9	BIRC5, MUC1, CDK6, CDKN1B, CCND1, IGFBP3
11	adpribose32	9.8	PCNA, RB1, BRCA2, BIRC5, PARP1, BCL2
12	tgf beta132	9.8	RARA, CDK6, CDKN1A, CD36, CDKN2B, CDKN1B
13	flavopiridol32 9 9	11.8	RB1, VEGFA, BIRC5, PARP1, BCL2, BAK1
14	ascorbic acid32 18	10.7	PCNA, SERPINB2, RAC1, CHUK, S100B, CD36
15	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	9.6	PCNA, PARP1, BCL2, BAK1, BAX, S100B
16	biotin32 9 18 9	12.6	PCNA, RB1, VIM, MUC1, S100A1, CDKN2A
17	sulindac sulfide32	9.5	PCNA, BCL2, BAX, JUN, CCND1, CASP3
18	glucose32	9.4	BRAF, PAK1, PARK2, CHUK, BAK1, LALBA
19	celecoxib32 42 34 9 18 9	14.4	PCNA, VEGFA, BIRC5, PARP1, BCL2, BAK1
20	3,3-diindolylmethane32	9.3	VEGFA, BIRC5, PARP1, BAX, CDK6, CDKN1A
21	eb 108932	9.2	PCNA, PARP1, BCL2, BAX, CDK6, CDKN1A
22	agarose32	9.2	PARP1, BCL2, MUC1, BAX, S100B, CDKN1A
23	cd 43732	9.2	RARA, RARB, PARP1, BCL2, BAX, JUN
24	calcitriol32 42 9 18 9	13.2	RB1, RARA, RARB, CHEK1, BAK1, JUN
25	rosiglitazone32 9 18 9	12.2	RARB, JUN, CDKN1A, CD36, MMP2, CCND1
26	mifepristone32 42 9 9	12.0	BIRC5, MUC1, BAX, JUN, MKI67, AR
27	arsenite32 18	9.9	PCNA, VEGFA, RARA, RAC1, BIRC5, PARP1
28	ciglitazone32	8.9	RARA, RARB, PARP1, BAX, JUN, CDKN1A
29	lactate32	8.8	PCNA, VIM, BIRC5, S100B, CD44, IVL
30	suberoylanilide hydroxamic acid32	8.8	BIRC5, PARP1, BCL2, BAX, CDKN1A, CCND1
31	quercetin32 42 9 18 9	12.8	BIRC5, PARP1, BCL2, CHUK, BAK1, BAX
32	geldanamycin32 9 9	10.7	BRAF, VEGFA, BIRC5, PARP1, PARK2, JUN
33	adriamycin32	8.6	RB1, VIM, BRCA2, BIRC5, BCL2, CHEK1
34	troglitazone32 42 9 9	11.5	RB1, RARA, BIRC5, BCL2, BAK1, BAX
35	docetaxel32 34 9 9	11.5	BRCA2, VEGFA, BIRC5, PARP1, BCL2, BAK1
36	15-deoxy-delta-12,14-prostaglandin j232	8.4	VEGFA, BIRC5, JUN, CDKN1A, CD36, FOS
37	butyrate32	8.2	RET, RB1, VIM, RARA, BIRC5, BCL2
38	pd 98,05932	8.1	RET, RB1, BRAF, RARA, RAC1, BIRC5
39	curcumin32	8.0	VEGFA, BIRC5, PARP1, PAK2, BCL2, CHUK
40	wortmannin32 42	9.0	RET, VIM, BRAF, RAC1, BIRC5, PAK1
41	actinomycin d32	7.2	RB1, SERPINB2, VIM, VEGFA, RARA, RARB
42	tamoxifen32 34 9 9	10.0	PCNA, VIM, BRCA2, VEGFA, RARA, BIRC5
43	lipid32	INF	RET, RB1, SERPINB2, VIM, BRAF, RARA
44	atp32	INF	RET, RB1, BRAF, RAC1, BIRC5, PAK1
45	nitric oxide32 9 18 9	INF	RB1, SERPINB2, BIRC5, PARK2, YY1, MUC1
46	estrogen32	INF	PCNA, SERPINB2, BRCA2, RARA, RARB, RASSF1
47	paraffin32	INF	RET, PCNA, RB1, SERPINB2, VIM, BRAF
48	cholesterol32 9 18 9	INF	RB1, RAC1, BIRC5, YY1, MUC1, CDKN1B
49	formaldehyde32 18	INF	PCNA, RB1, VIM, MUC1, S100B, CDKN1B
50	thymidine32 18	INF	PCNA, RB1, BRCA2, RARA, RARB, RAC1

Cellular components related to papilloma according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	nuclear chromatin	GO:000790	10.2	POU4F1, RXRA, TP53, AR, UBE2B, MUC1
2	axon	GO:030424	9.4	TGFB1, NF1, RXRA, SRCIN1, AR, PAK1
3	extracellular space	GO:005615	8.7	IFNB1, IFNG, CTSB, EGF, EGFR, TTR
4	nucleoplasm	GO:005654	7.8	PIN1, PCNA, RB1, BRCA2, RARA, RARB
5	plasma membrane	GO:005886	6.1	EGFR, EGF, KRT1, PKM, RPS27A, PTEN
6	nucleus	GO:005634	4.7	PTEN, PTGS2, PTGES2, CYCS, SP8, PPARD
7	cytosol	GO:005829	INF	DMD, CYCS, ODC1, RPS27, RPS27A, PTGES2
8	keratin filament	GO:045095	INF	KRT14, KRTAP11-1, KRT10, KRT1, , KRT7
9	cytoplasm	GO:005737	INF	ACTC1, SLC23A1, PGR, RLBP1, SIPA1L1, POU2F2
10	intermediate filament	GO:005882	INF	GFAP, KRT14, KRT20, KRT10, KRT1,
11	protein complex	GO:043234	INF	TP53, PTGS2, DMD, TOP2A, , CAV1

Biological processes related to papilloma according to GeneDecks:

(show top 50)    (show all 79)

id	Name	GO ID	Score	Top Affiliating Genes
1	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:006977	10.8	PSMB8, RPS27A, TP53, CASP2, CDKN1B, CDKN1A
2	cell cycle checkpoint	GO:000075	10.7	PSMB8, RPS27A, TP53, CCNE2, CDKN2A, CDKN1B
3	G1 phase of mitotic cell cycle	GO:000080	10.6	RPS27A, CCND1, CDKN2A, CDKN1B, CDKN2B, CDKN1A
4	mitotic cell cycle	GO:000278	10.5	CCNE2, CCND1, RPS27, RPS27A, TOP2A, PSMB8
5	G1/S transition of mitotic cell cycle	GO:000082	10.5	CDKN2A, CCNE2, CCND1, RPS27A, PSMB8, CDKN1B
6	negative regulation of cyclin-dependent protein kinase activity	GO:045736	10.5	CASP3, MEN1, CDKN2A, CDKN1B, CDKN1A
7	neuron apoptotic process	GO:051402	10.4	TP63, TP53, CASP3, BAX, BCL2, RB1
8	response to gamma radiation	GO:010332	10.4	TP53, CAV1, MEN1, BAX, BAK1, BCL2
9	activation of pro-apoptotic gene products	GO:008633	10.4	CASP8, IFI27, FADD, BAX, BAK1, BCL2
10	cell cycle arrest	GO:007050	10.4	TGFB1, TP53, IFNG, MEN1, CDKN2A, CDKN1B
11	induction of apoptosis by intracellular signals	GO:008629	10.3	CYCS, TP53, CASP8, CASP3, CDKN1A, BAX
12	negative regulation of epithelial cell proliferation	GO:050680	10.3	TGFB1, KRT4, PPARD, PTEN, AR, CDKN2B
13	cell proliferation	GO:008283	10.3	PTEN, PPARD, RPS27, EGFR, TYR, TGFA
14	type I interferon-mediated signaling pathway	GO:060337	10.3	PSMB8, STAT1, STAT2, TYK2, HLA-G, HLA-B
15	mammary gland alveolus development	GO:060749	10.2	TGFA, EGF, CCND1, AR, CHUK
16	positive regulation of peptidyl-serine phosphorylation	GO:033138	10.2	TGFB1, CAV1, CD44, BCL2, PAK1, VEGFA
17	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.2	TP53, IGF2, CD44, CD4, CD36, PAK2
18	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	10.2	PSMB8, UBC, CD36, CD207, HLA-B, HLA-G
19	regulation of apoptotic process	GO:042981	10.1	PSMB8, STAT1, RPS27A, CTSB, DAPK1, TP53
20	negative regulation of transcription, DNA-dependent	GO:045892	10.1	IFNA2, HMGA1, TP53, TP63, PPARD, NR1H2
21	response to ethanol	GO:045471	10.1	BAK1, CCND1, CASP8, CTSB, RXRA, ACTC1
22	negative regulation of apoptotic process	GO:043066	10.1	CD44, AR, CCNG1, CASP3, TP53, PTEN
23	release of cytochrome c from mitochondria	GO:001836	10.0	TP53, CASP3, JUN, BAX, BAK1, BCL2
24	positive regulation of apoptotic process	GO:043065	10.0	TP53, PTGS2, RXRA, NF1, TOP2A, POU4F1
25	MAPK cascade	GO:000165	10.0	TGFB1, TGFA, EGFR, NF1, CAV1, MEN1
26	response to DNA damage stimulus	GO:006974	9.9	MEN1, CCND1, CASP3, TP53, TOP2A, CDKN1A
27	induction of apoptosis by extracellular signals	GO:008624	9.9	CASP2, CASP8, CAV1, DAPK1, RPS27A, CASP3
28	epidermal growth factor receptor signaling pathway	GO:007173	9.9	EGFR, TGFA, TGFB1, PXN, PRKCE, EGF
29	transforming growth factor beta receptor signaling pathway	GO:007179	9.8	TGFB1, RPS27A, TP53, MEN1, FOS, CDKN2B
30	antigen processing and presentation of peptide antigen via MHC class I	GO:002474	9.8	PSMB8, RPS27A, CTSS, HLA-G, HLA-B, CD207
31	cytokine-mediated signaling pathway	GO:019221	9.7	RPS27A, TYK2, STAT2, STAT3, STAT1, PSMB8
32	negative regulation of protein phosphorylation	GO:001933	9.7	TGFB1, PTEN, IGFBP3, IL2, MEN1, PARK2
33	positive regulation of cell proliferation	GO:008284	9.7	PTEN, ODC1, PPARD, EGF, EGFR, TGFB1
34	response to virus	GO:009615	9.7	STAT1, STAT2, ODC1, HMGA1, IFNG, IFNB1
35	DNA repair	GO:006281	9.6	FOXM1, MEN1, RPS27A, TOP2A, TFPT, XRCC5
36	negative regulation of cell proliferation	GO:008285	9.6	IGFBP3, IFNB1, HMGA1, TP53, PTEN, PTGS2
37	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.6	RPS27A, CASP8, FADD, CD36, S100B, UBC
38	transcription initiation from RNA polymerase II promoter	GO:006367	9.6	PPARD, NR1H2, NR2C1, RXRA, RPS27A, PGR
39	response to organic cyclic compound	GO:014070	9.5	STAT3, RXRA, CTSB, PTGS2, CCND1, CDKN1A
40	innate immune response	GO:045087	9.5	FADD, IFNA2, IFNB1, CASP8, CTSS, CTSB
41	positive regulation of transcription, DNA-dependent	GO:045893	9.5	TP53, TP63, PTGES2, PPARD, EGF, TGFB1
42	induction of apoptosis	GO:006917	9.4	PTEN, DAPK1, TGFB1, TFPT, STAT1, PRKCE
43	apoptotic process	GO:006915	9.4	CYCS, DAPK1, PTEN, TP63, TP53, PPARD
44	nerve growth factor receptor signaling pathway	GO:048011	9.4	PRKCE, STAT3, RPS27A, PTEN, CASP2, CASP3
45	virus-host interaction	GO:019048	9.3	TP53, SMARCB1, RXRA, KRT7, TGFB1, STAT2
46	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.3	TP53, PPARD, NR2C1, RXRA, RPS27A, TGFB1
47	response to drug	GO:042493	9.2	PTGS2, ACTC1, TOP2A, TGFA, TGFB1, STAT3
48	protein phosphorylation	GO:006468	9.2	ERBB2, DAPK1, EIF2AK4, TYK2, TGFB1, PRKCE
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.4	RB1, IFNG, ESR1, TP53, TP63, NR1H2
50	cellular response to organic substance	GO:071310	INF	, TIMP2, CASP3, BAX, BCL2

Molecular functions related to papilloma according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:005198	10.7	CSTA, KRTAP11-1, KRT10, KRT7, KRT13, KRT4
2	cyclin-dependent protein kinase inhibitor activity	GO:004861	10.6	CASP3, CDKN2A, CDKN1B, CDKN2B, CDKN1A
3	retinoic acid receptor activity	GO:003708	10.4	RARA, RARB, RXRA
4	transcription factor binding	GO:008134	10.0	AR, HMGA1, TP53, STAT3, CDKN2A, JUN
5	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	9.9	STAT3, RXRA, NR1H2, PPARD, AR
6	transcription regulatory region DNA binding	GO:044212	9.8	STAT3, RXRA, TP63, TP53, MEN1, AR
7	sequence-specific DNA binding	GO:043565	9.8	NR1H2, NR2C1, RXRA, TOP2A, STAT3, POU2F2
8	steroid hormone receptor activity	GO:003707	9.8	PGR, RXRA, NR2C1, NR1H2, PPARD, ESR1
9	protein heterodimerization activity	GO:046982	9.7	TP53, RXRA, EGFR, TYR, TOP2A, TGFB1
10	protein kinase binding	GO:019901	9.6	CCND1, TP53, PTEN, SRCIN1, STAT3, PRKCE
11	cytokine activity	GO:005125	9.2	CSF2, IFNG, IFNB1, IFNA2, IL27, IL2
12	protein homodimerization activity	GO:042803	9.1	PTGS2, NR2C1, SHBG, EIF2AK4, TYR, TOP2A
13	sequence-specific DNA binding transcription factor activity	GO:003700	8.8	TP53, PPARD, NR2C1, RXRA, TADA3, STAT2
14	enzyme binding	GO:019899	7.9	CASP2, CAV1, ESR1, HMGA1, TP53, PTEN
15	identical protein binding	GO:042802	INF	S100B, FADD, CASP8, ESR1, ERBB2, TP53
16	structural constituent of cytoskeleton	GO:005200	INF	GFAP, KRT14, KRT20, KRT1, , PLS1
17	calcium ion binding	GO:005509	INF	EGF, DSG3, TCHH, , STAT2, STAT3
18	protein binding	GO:005515	INF	ESR1, NF1, KRT7, , KRT1, KRT20