MCID: PPL022
MIFTS: 60

Papilloma malady

Summaries for Papilloma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A cell type benign neoplam that is composed of epithelial tissue on papillae of vascularized connective tissue.

MalaCards: Papilloma, also known as papillomatosis, is related to choroid plexus papilloma and squamous cell carcinoma. An important gene associated with Papilloma is UBE3A (ubiquitin protein ligase E3A), and among its related pathways are MicroRNAs in cancer and Pathways in cancer. The drugs podophyllin and podophyllin pwdr and the compounds paraffin and retinoic acid have been mentioned in the context of this disorder. Related mouse phenotypes are cellular and integument.

Wikipedia:64 Papilloma (plural papillomas or papillomata) (papillo- + -oma) refers to a benign epithelial tumor... more...

Aliases & Classifications for Papilloma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

papilloma 8 10 45 61
papillomatosis 8 45 61
papillomatosis, nos 8
papillomatosis nos 8


External Ids:

Disease Ontology8 DOID:2615
NCIt40 C7440
MeSH35 D010212

Related Diseases for Papilloma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Papilloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 390)
idRelated DiseaseScoreTop Affiliating Genes
1choroid plexus papilloma31.5CT49, S100B
2squamous cell carcinoma31.1TP53, TP63, ACTC1, KRT13, KRT20, RASSF1
3bladder transitional cell papilloma30.7FGFR3
4papillary carcinoma30.6TP63, ACTC1, KRT20, CDKN1B, MKI67, IFI27
5bladder carcinoma30.5TP53, ACTC1, KRT20, RASSF1, FGFR3, CDKN1A
6transitional cell carcinoma30.5TP53, TP63, KRT20, FGFR3, PCNA, CDKN1A
7cervical intraepithelial neoplasia30.5CDKN2A, MKI67, IFI27
8adenocarcinoma30.4TP53, TP63, ACTC1, KRT13, KRT20, RASSF1
9bladder transitional cell carcinoma30.3TP53, KRT20, MKI67, IFI27
10adenoma30.3TP53, TP63, ACTC1, KRT13, KRT20, RASSF1
11oral cancer30.3TP53, KRT13, PCNA, CDKN1B, CDKN1A, CDKN2A
12ductal carcinoma in situ30.2TP53
13leukoplakia30.2KRT13, PCNA, MKI67, IFI27
14ependymoma30.2RASSF1, MKI67, CT49, S100B
15oral leukoplakia30.2TP63, PCNA, MKI67, IFI27
16lichen planus30.1KRT13
17neuroendocrine carcinoma30.0TP63, KRT20, FSCN1, S100B
18basal cell carcinoma29.9TP53, TP63, ACTC1, KRT20, MKI67
19teratoma29.9ACTC1
20choroid plexus carcinoma29.9CT49, S100B
21fibromatosis29.8ACTC1
22colorectal cancer29.7TP53, KRT20, RASSF1, FSCN1, FGFR3, PCNA
23astrocytoma29.7TP53, RASSF1, FSCN1, PCNA, CDKN1B, CDKN1A
24adenoid cystic carcinoma29.7TP63, ACTC1, KRT20, RASSF1, PCNA, MKI67
25mucoepidermoid carcinoma29.7TP63, ACTC1, KRT13, PCNA, CDKN1B, MKI67
26bladder carcinoma in situ29.7TP53, KRT20, RASSF1, FGFR3, PCNA, CDKN2A
27synovial sarcoma29.7KRT13, RASSF1, MKI67, S100B
28malignant mixed mullerian tumor29.7TP53, ACTC1, S100B
29tongue cancer29.7CDKN1A
30li-fraumeni syndrome29.7TP53, CDKN2A
31dermatofibrosarcoma protuberans29.7ACTC1, S100B
32spindle cell carcinoma29.7TP63, ACTC1
33squamous cell papilloma10.8
34biliary papillomatosis10.8
35intraductal papilloma10.8
36ureter inverted papilloma10.6
37urinary bladder inverted papilloma10.5
38transitional papilloma10.5
39atypical choroid plexus papilloma10.5
40intrahepatic biliary papillomatosis10.5
41inverted transitional papilloma10.4
42frontal sinus inverted papilloma10.4
43sphenoid sinus inverted papilloma10.4
44verrucous papilloma10.4
45acanthosis nigricans10.4
46gallbladder papillomatosis10.4
47maxillary sinus inverted papilloma10.4
48renal pelvis inverted papilloma10.4
49esophagus squamous cell papilloma10.4
50choroid plexus cyst10.4

Graphical network of the top 20 diseases related to Papilloma:



Diseases related to papilloma

Clinical Features for Papilloma

Drugs & Therapeutics for Papilloma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Papilloma

Drug clinical trials:

Search ClinicalTrials for Papilloma

Search NIH Clinical Center for Papilloma

Search CenterWatch for Papilloma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Papilloma

Anatomical Context for Papilloma

Animal Models for Papilloma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Papilloma

Sources:
51PubMed
See all sources

Articles related to Papilloma:

(show top 50)    (show all 4109)
idTitleAuthorsYear
1
Squamous cell papilloma of the urinary bladder endoscopically mimicking cancer. (24159399)
2013
2
Human papillomavirus type 16 causes larger colposcopic lesions than other HPV types in patients with grade 3 cervical intraepithelial neoplasia. (23222045)
2013
3
Frequency and type-distribution of human papillomavirus from paraffin-embedded blocks of high grade cervical intraepithelial neoplasia lesions in Thailand. (23621179)
2013
4
Adequacy of fine-needle aspiration specimens for human papillomavirus infection molecular testing in head and neck squamous cell carcinoma. (24403949)
2013
5
Management of benign intraductal solitary papilloma diagnosed on core needle biopsy. (23314624)
2013
6
Trials and projects on cervical cancer and human papillomavirus prevention in sub-saharan Africa. (24331748)
2013
7
Vaccinating HIV patients: focus on human papillomavirus and herpes zoster vaccines. (23681435)
2013
8
Experience of 11 years use of cidofovir in recurrent respiratory papillomatosis. (23070260)
2013
9
Cytopathic effects of human papillomavirus infection and the severity of cervical intraepithelial neoplasia : A frequency study. (21591275)
2012
10
The role of human papillomavirus in oral squamous cell carcinoma: myth and reality. (23242943)
2012
11
Human papillomavirus distribution in vulvar intraepithelial neoplasia. (22300742)
2012
12
Oral focal epithelial hyperplasia: report of 3 cases with human papillomavirus DNA sequencing analysis. (22353414)
2011
13
Radiological localization of Schneiderian papilloma. (22144059)
2011
14
Demyelinating disease and polyvalent human papilloma virus vaccination. (20935322)
2011
15
Abnormal cell-cycle expression of the proteins p27, mdm2 and cathepsin B in oral squamous-cell carcinoma infected with human papillomavirus. (19811804)
2011
16
Recurrent respiratory papillomatosis: an uncommon but potentially devastating effect of human papillomavirus in children. (20606216)
2010
17
FGFR3 and TP53 mutation analysis in inverted urothelial papilloma: incidence and etiological considerations. (19287463)
2009
18
Prevalence and risk factors for human papillomavirus and cervical intraepithelial neoplasia among HIV-positive women at a tertiary level hospital in India. (19550213)
2009
19
Cutaneous human papillomavirus infection, the EVER2 gene and incidence of squamous cell carcinoma: a case-control study. (18224692)
2008
20
Apicidin down-regulates human papillomavirus type 16 E6 and E7 transcripts and proteins in SiHa cervical cancer cells. (18687520)
2008
21
Benign epithelial proliferations in axillary lymph nodes with ipsilateral breast in situ ductal carcinoma and intraductal papilloma of the breast. (18439159)
2008
22
Recurrent respiratory papillomatosis: an overview of current thinking and treatment. (18046565)
2008
23
Humoral and cellular immune responses to airway immunization of mice with human papillomavirus type 16 virus-like particles and mucosal adjuvants. (17617476)
2007
24
E7 properties of mucosal human papillomavirus types 26, 53 and 66 correlate with their intermediate risk for cervical cancer development. (17568647)
2007
25
Outcomes of the extended endoscopic approach for management of inverted papilloma. (17459277)
2007
26
Recurrent respiratory papillomatosis. (16861486)
2006
27
Human papillomaviruses target the double-stranded RNA protein kinase pathway. (17030851)
2006
28
Human papillomavirus localization in cervical adenocarcinoma and adenosquamous carcinoma using in situ polymerase chain reaction: review of the literature of human papillomavirus detection in these carcinomas. (16704493)
2006
29
British Association of Paediatric Otorhinolaryngology members experience with recurrent respiratory papillomatosis. (16414125)
2006
30
Detection of human papillomavirus (HPV) 16-specific CD4+ T-cell immunity in patients with persistent HPV16-induced vulvar intraepithelial neoplasia in relation to clinical impact of imiquimod treatment. (16033846)
2005
31
p53 at codon 72 polymorphism, human papillomavirus infection and cervical lesions: a cross-sectional study from northeastern Italy. (15140517)
2004
32
Integrations of the hepatitis B virus (HBV) and human papillomavirus (HPV) into the human telomerase reverse transcriptase (hTERT) gene in liver and cervical cancers. (12802289)
2003
33
Histopathologic and biologic characteristics of a transitional cell carcinoma with inverted papilloma-like endophytic growth pattern. (12670580)
2003
34
Nucleolin as activator of human papillomavirus type 18 oncogene transcription in cervical cancer. (12391018)
2002
35
Displacement of YY1 by differentiation-specific transcription factor hSkn-1a activates the P(670) promoter of human papillomavirus type 16. (11533193)
2001
36
Human papillomavirus-16-E7 oncoprotein enhances the expression of adhesion molecules in cervical endothelial cells but not in human umbilical vein endothelial cells. (11437318)
2001
37
Inverted papilloma. (10862443)
2000
38
Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue. (11127826)
2000
39
Putative regulatory sequence in human papillomavirus type 16 E2 open reading frame. (9158949)
1997
40
A comparative analysis of the interactions of the E6 proteins from cutaneous and genital papillomaviruses with p53 and E6AP in correlation to their transforming potential. (9426453)
1997
41
Treatment of recurrent respiratory papillomatosis with argon plasma coagulation. (9176627)
1997
42
A preliminary study on p53 gene expression and infection of human papilloma virus in laryngeal squamous cell carcinoma]. (9868114)
1997
43
Detection of human papillomavirus (HPV) type 47 DNA in malignant lesions from epidermodysplasia verruciformis by protocols for precise typing of related HPV DNAs. (8789018)
1996
44
A case of inverted papilloma of the ureter: is the DNA ploidy pattern associated with occurrence of transitional cell carcinoma of the bladder? (8026919)
1994
45
Host response to papilloma virus in focal epithelial hyperplasia. (2551213)
1989
46
Laryngeal papillomatosis. (3621831)
1987
47
Juvenile laryngeal papillomatosis. (3958590)
1986
48
Identification of three distinct papillomavirus genomes in a single patient with epidermodysplasia verruciformis. (6300202)
1983
49
Squamous cell papilloma of the esophagus: a tumour probably caused by human papilloma virus (HPV). (6188592)
1982
50
A fatality from juvenile laryngeal papillomatosis. (6065953)
1967

Genetic Variations for Papilloma

Expression for genes affiliated with Papilloma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Papilloma

Search GEO for disease gene expression data for Papilloma.

Pathways for genes affiliated with Papilloma

Sources:
30KEGG, 54Reactome, 4Cell Signaling Technology, 38NCBI BioSystems Database, 53R&D Systems, 52QIAGEN, 12EMD Millipore
See all sources

Pathways related to Papilloma according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0TP53, CDKN2A, CDKN1A, CDKN1B, FGFR3, FSCN1
210.9CDKN2A, CDKN1A, CDKN1B, FGFR3, RASSF1, TP53
3
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10.9FGFR3, CDKN1B, CDKN1A, UBE3A, S100B, IFI27
4
Hide members
10.9TP63, PCNA, CDKN1B, CDKN1A, CDKN2A, MKI67
510.8UBE3A, CDKN2A, CDKN1A, CDKN1B, TP53
6
Hide members
10.8CDKN2A, CDKN1A, CDKN1B, PCNA, TP53
710.8CDKN2A, CDKN1A, CDKN1B, PCNA, TP53
810.8TP53, FGFR3, CDKN1B, CDKN1A
910.8TP53, TP63, CDKN1A, CDKN2A
10
Hide members
10.8TP53, CDKN1B, CDKN1A, CDKN2A
11
Hide members
10.8CDKN2A, CDKN1A, CDKN1B, TP53
1210.8CDKN2A, CDKN1A, CDKN1B, TP53
13
Hide members
10.8TP53, CDKN1B, CDKN1A, CDKN2A
14
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10.8TP53, CDKN1B, CDKN1A, CDKN2A
15
Hide members
10.8S100B, CDKN1A, CDKN1B, FGFR3
1610.8CDKN1A, PCNA, TP63, TP53
17
Hide members
10.8TP53, PCNA, CDKN1B, CDKN1A
1810.8TP53, PCNA, CDKN1B, CDKN1A
19
Hide members
10.8CDKN1A, CDKN1B, PCNA, TP53
2010.8CDKN2A, CDKN1A, PCNA, TP53
21
Hide members
10.8PCNA, CDKN1B, CDKN1A, CDKN2A
22
Cell cycle Cell cycle (generic schema)
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10.8PCNA, CDKN1B, CDKN1A, CDKN2A
23
Hide members
10.7TP53, FGFR3, UBE3A
24
Hide members
10.7CDKN1A, FGFR3, TP53
25
Transcription P53 signaling pathway
Hide members
10.7TP53, CDKN1A, CDKN2A
2610.7CDKN1A, PCNA, TP53
2710.7TP53, PCNA, CDKN1A
28
Hide members
10.6TP63, TP53
2910.5CDKN1A

Compounds for genes affiliated with Papilloma

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Papilloma according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1paraffin4512.0CDKN1B, TP53, TP63, ACTC1, KRT13, KRT20
2retinoic acid45 2412.9S100B, CT49, MKI67, CDKN2A, CDKN1A, CDKN1B
3progesterone45 60 29 11 2415.8CDKN1A, LALBA, ACTC1, IFI27, S100B, CT49
4vegf4511.8IFI27, S100B, TP53, TP63, ACTC1, KRT20
5tyrosine4511.7S100B, IFI27, KRT20, TP63, ACTC1, LALBA
6doxorubicin45 50 1113.6TP53, TP63, FGFR3, CDKN1B, CDKN1A, CDKN2A
7testosterone45 60 11 2414.6PCNA, KRT20, ACTC1, TP63, CT49, CDKN1B
8arginine4511.6MKI67, TP53, TP63, PCNA, LALBA, FGFR3
9cisplatin45 50 60 1114.5CDKN2A, TP63, RASSF1, CDKN1A, MKI67, IFI27
10thymidine45 2412.5IFI27, TP53, TP63, PCNA, CDKN1B, CDKN1A
11oligonucleotide4511.5TP53, IFI27, CDKN2A, PCNA, CDKN1A, CDKN1B
12threonine4511.5CDKN1A, MKI67, S100B, CDKN2A, IFI27, RASSF1
13serine4511.4FSCN1, CDKN1A, CDKN1B, RASSF1, TP53, FGFR3
14hematoxylin4511.4KRT20, PCNA, MKI67, ACTC1, TP63, S100B
15bromodeoxyuridine4511.4S100B, IFI27, MKI67, CDKN1A, CDKN1B, PCNA
16steroid4511.4UBE3A, CT49, IFI27, CDKN2A, ACTC1, LALBA
17paclitaxel45 50 1113.3S100B, TP53, CDKN1A, CDKN2A, IFI27, CDKN1B
18cytarabine45 50 1113.3IFI27, CDKN2A, CDKN1B, PCNA, CDKN1A, TP53
19p0034511.3RASSF1, S100B, IFI27, MKI67, CDKN1B, TP63
20thymidylate4511.3IFI27, PCNA, TP53, CDKN2A, CDKN1A, MKI67
21mg 13245 6012.3TP53, PCNA, CDKN1B, CDKN2A, IFI27, CDKN1A
22formaldehyde45 2412.3S100B, MKI67, PCNA, KRT20, ACTC1, CDKN1B
235-aza-2deoxycytidine4511.3CDKN2A, PCNA, CT49, CDKN1A, RASSF1, TP53
24alanine4511.3S100B, PCNA, CDKN2A, CT49, RASSF1, UBE3A
25b 7234511.2KRT20, ACTC1, S100B, TP63, PCNA
265fluorouracil4511.2TP53, CDKN2A, PCNA, MKI67, CDKN1B, CDKN1A
27roscovitine4511.2CDKN2A, IFI27, TP53, PCNA, CDKN1A
28n acetylcysteine4511.2TP53, CDKN1A, IFI27, PCNA, CDKN1B, CDKN2A
29tamoxifen45 50 29 1114.2PCNA, IFI27, TP53, MKI67, CDKN1A, CDKN1B
30hpvs4511.2CDKN1A, TP53, UBE3A, CDKN2A
31mucicarmine4511.1ACTC1, S100B, TP63, KRT20
32olomoucine45 1112.1CDKN2A, PCNA, TP53, CDKN1A
33temozolomide45 1112.1TP53, PCNA, CDKN1A, CDKN2A
34troglitazone45 29 60 1114.1KRT20, CDKN1B, CDKN1A, IFI27, KRT13
35o6-methylguanine4511.1PCNA, TP53, CDKN2A, RASSF1
36eb 108945 6012.1IFI27, CDKN1A, CDKN1B, PCNA
37aphidicolin4511.1PCNA, CDKN1A, CDKN1B, TP53
38camptothecin45 60 1113.1CDKN2A, TP53, PCNA, CDKN1B, CDKN1A
39indole-3-carbinol4511.1TP53, CDKN1A, IFI27, CDKN1B
40sulindac45 1112.0CDKN1A, TP53, PCNA, IFI27
41estrogen4511.0LALBA
42imatinib45 50 1113.0ACTC1, S100B, CDKN1A, CDKN1B, FGFR3
43methanol45 2412.0LALBA, ACTC1, CDKN2A, MKI67
44acnu4510.9TP53, CDKN1A, CDKN2A
45flavopiridol45 1111.8CDKN1B, CDKN2A, CDKN1A, TP53
46norcantharidin4510.8IFI27, PCNA, MKI67
47celecoxib45 60 29 50 11 2415.8CDKN1A, CDKN1B, PCNA, MKI67
482-methoxyethanol4510.7TP63, ACTC1, UBE3A
49reticulin4510.6S100B, ACTC1, PCNA
50dexamethasone45 50 29 1113.5IFI27, CDKN2A, PCNA, S100B, CDKN1B

GO Terms for genes affiliated with Papilloma

Sources:
16Gene Ontology
See all sources

Cellular components related to Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.0S100B, UBE3A, MKI67, CDKN2A, CDKN1B, PCNA
2nucleoplasmGO:00565410.9CDKN1A, CDKN1B, PCNA, TP63, TP53, CDKN2A
3PCNA-p21 complexGO:07055710.5PCNA, CDKN1A

Biological processes related to Papilloma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cell cycle arrestGO:00705011.1TP53, RASSF1, CDKN1B, CDKN1A, CDKN2A
2Ras protein signal transductionGO:00726511.0TP53, RASSF1, CDKN1A, CDKN2A
3cell proliferationGO:00828311.0S100B, MKI67, PCNA, FSCN1, TP53
4negative regulation of cell growthGO:03030811.0CDKN2A, CDKN1A, CDKN1B, TP53
5mitotic cell cycle arrestGO:07185011.0CDKN1A, CDKN1B, TP53
6phosphatidylinositol-mediated signalingGO:04801511.0CDKN1A, CDKN1B, PCNA, FGFR3
7negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:04573610.9CDKN2A, CDKN1A, CDKN1B
8negative regulation of phosphorylationGO:04232610.9CDKN1B, CDKN1A, CDKN2A
9negative regulation of apoptotic processGO:04306610.9CDKN1A, CDKN1B, FGFR3, TP63, TP53
10DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00697710.8TP53, CDKN1B, CDKN1A
11G1/S transition of mitotic cell cycleGO:00008210.7PCNA
12activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.7CDKN1B, CDKN2A, IFI27
13DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.6TP53, TP63
14mitotic G1 DNA damage checkpointGO:03157110.5TP63, TP53
15replicative senescenceGO:09039910.3TP53, CDKN2A

Molecular functions related to Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.1S100B, UBE3A, MKI67, CDKN2A, CDKN1A, CDKN1B
2identical protein bindingGO:04280210.8TP53, TP63, RASSF1, PCNA, S100B
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.8CDKN1B, CDKN1A, CDKN2A
4MDM2/MDM4 family protein bindingGO:09737110.6TP53, CDKN2A
5p53 bindingGO:00203910.6CDKN2A, TP63, TP53

Products for genes affiliated with Papilloma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Papilloma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet