MCID: PRC011
MIFTS: 34

Parachordoma malady

Cancer diseases category

Summaries for Parachordoma

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34MalaCards
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MalaCards: Parachordoma is related to chordoma and sarcoma. An important gene associated with Parachordoma is T (T, brachyury homolog (mouse)), and among its related pathways is Striated Muscle Contraction. The compounds eosin and orcein have been mentioned in the context of this disorder.

Aliases & Classifications for Parachordoma

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

parachordoma 9 11 63


External Ids:

Disease Ontology9 DOID:2647
NCIt41 C6581

Related Diseases for Parachordoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Parachordoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1chordoma30.4DES, MUC1, CEACAM3, S100B, KRT7
2sarcoma30.0DES, MUC1, S100B
3chondrosarcoma29.9S100B, CEACAM3, MUC1, DES
4chest wall parachordoma10.4
5myoepithelioma10.2
6glomus tumor10.1DES
7metanephric adenoma10.1KRT7
8nephrogenic adenoma10.1KRT7
9synovial sarcoma10.1KRT7
10cystadenocarcinoma10.1MUC1, CEACAM3
11pulmonary alveolar proteinosis10.1MUC1, CEACAM3
12mesenchymal chondrosarcoma10.1DES, MUC1
13desmoplastic small round cell tumor10.1DES, MUC1
14spindle cell carcinoma10.1DES, MUC1
15papilloma10.1KRT20
16sertoli cell tumor10.1DES, MUC1
17malignant pleural mesothelioma10.1MUC1, CEACAM3
18rhabdoid tumor10.1DES, MUC1
19kidney cancer10.1KRT7
20merkel cell carcinoma10.1MUC1, KRT20
21rectal neoplasm10.1CEACAM3, KRT20
22sertoli-leydig cell tumor10.0KRT7, MUC1
23bowen syndrome10.0CEACAM3, KRT7
24epithelioid sarcoma10.0MUC1, KRT7
25cystadenoma10.0CEACAM3, KRT7
26secretory meningioma10.0MUC1, KRT7
27bladder adenocarcinoma10.0KRT7, KRT20
28signet ring cell adenocarcinoma10.0KRT7, KRT20
29ovarian brenner tumor10.0KRT7, KRT20
30gallbladder cancer10.0KRT7, CEACAM3
31pancreatic ductal carcinoma10.0KRT7, KRT20
32mucoepidermoid carcinoma10.0KRT7, MUC1
33fibrous meningioma10.0MUC1, S100B
34pseudomyxoma peritonei10.0KRT20, KRT7
35choroid plexus papilloma10.0MUC1, S100B
36bronchiolo-alveolar adenocarcinoma10.0KRT20, KRT7
37anaplastic ependymoma10.0MUC1, S100B
38cervical adenocarcinoma10.0KRT7, KRT20
39meningioma10.0MUC1, S100B
40neuroendocrine tumor10.0CEACAM3, KRT20
41renal clear cell carcinoma10.0KRT7, MUC1
42cutaneous fibrous histiocytoma10.0DES, S100B
43perineurioma10.0MUC1, S100B
44carcinoid syndrome10.0KRT20, CEACAM3, MUC1
45granular cell tumor10.0DES, S100B
46fibrous histiocytoma10.0DES, S100B
47hemangioblastoma10.0S100B, MUC1
48extraskeletal myxoid chondrosarcoma10.0
49intestinal obstruction10.0
50myxoid chondrosarcoma10.0

Graphical network of the top 20 diseases related to Parachordoma:



Diseases related to parachordoma

Symptoms for Parachordoma

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Drugs & Therapeutics for Parachordoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Parachordoma

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Anatomical Context for Parachordoma

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Animal Models for Parachordoma or affiliated genes

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Publications for Parachordoma

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53PubMed
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Articles related to Parachordoma:

(show all 42)
idTitleAuthorsYear
1
A case of parachordoma on the chest wall and literature review. (24135242)
2013
2
Parachordoma/myoepithelioma. (22618759)
2013
3
Parachordoma of soft tissues of the arm: a very rare tumour. (24083043)
2013
4
Huge pelvic parachordoma: fine needle aspiration cytology and histological differential diagnosis. (23372917)
2012
5
Clinical and radiological presentations of pelvic parachordoma. (22532921)
2012
6
Intraneural parachordoma of the arm with regional metastases. (21499979)
2011
7
Presacral parachordoma causing intestinal obstruction in a patient with renal failure: Report of a case. (21922364)
2011
8
Axial chordoma and parachordoma (soft tissue chordoma): two of a kind: report of two cases with primary diagnosis on fine-needle cytology samples. (20730897)
2011
9
Parachordoma: a recurrent case and review of the literature. (21630208)
2011
10
Fine needle aspiration appearance of parachordoma. (20306999)
2010
11
Parachordoma of skull. (20303594)
2010
12
Metastatic parachordoma. (19208078)
2009
13
Pulmonary metastases from parachordoma. (19632372)
2009
14
Parachordoma: a very rare tumour of the hand. (20067931)
2009
15
Possible parachordoma in a dog. (19802045)
2009
16
Case report: parachordoma of soft tissues of the arm. (18219545)
2008
17
Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue. (18301055)
2008
18
Parachordoma or myoepithelion?: a case report of a rare soft tissue tumor. (17295651)
2007
19
Parachordoma of the gastric serosa: report of a myxoid mimicry in an unusual location. (17652546)
2007
20
Fatal parachordoma. (17260126)
2007
21
Retroperitoneal parachordoma in a patient with a history of recurrent pain. (15863385)
2005
22
Parachordoma is not distinguishable from axial chordoma using immunohistochemistry. (15086843)
2004
23
Parachordoma of tibia--a case report. (15025303)
2003
24
Parachordoma or chordoma periphericum? Case report of a tumor of the thoracic wall. (12827710)
2003
25
Parachordoma with multiple metastases. (12886158)
2003
26
Parachordoma: a case report. (11504379)
2001
27
Parachordoma exists--but what is it? (10809219)
2000
28
Parachordoma of the tibia: report of a rare case. (10782472)
2000
29
Parachordoma is immunohistochemically and cytogenetically distinct from axial chordoma and extraskeletal myxoid chondrosarcoma. (10478665)
1999
30
Chest wall parachordoma. (10609912)
1999
31
Parachordoma: a rare sarcoma with clonal chromosomal changes. (9530345)
1998
32
Cytogenetic analysis of a parachordoma. (9689924)
1998
33
Cutaneous parachordoma. A light microscopic and immunohistochemical report of two cases and review of the literature. (9696295)
1998
34
Parachordoma: a clinicopathologic and immunohistochemical study of four cases of an unusual soft tissue neoplasm. (9869820)
1997
35
Parachordoma. A case report of a very rare soft tissue tumor. (8950765)
1996
36
Parachordoma of the sacrococcygeal region--a neuroepithelial tumor. (8605741)
1995
37
Parachordoma--a clinicopathologic, immunohistochemical, electron microscopic, flow cytometric, and cytogenetic study. (8542507)
1995
38
Parachordoma of the buttock: an immunohistochemical case study and review. (7530308)
1994
39
Parachordoma. (8030773)
1994
40
Parachordoma. (8191635)
1994
41
Parachordoma: an ultrastructural and immunohistochemical study. (8493780)
1993
42
Parachordoma: a new clinicopathologic entity. (907973)
1977

Variations for Parachordoma

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Expression for genes affiliated with Parachordoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Parachordoma

Search GEO for disease gene expression data for Parachordoma.

Pathways for genes affiliated with Parachordoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome
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Pathways related to Parachordoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6MYH11, DES

Compounds for genes affiliated with Parachordoma

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Parachordoma according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1eosin4610.0S100B, MUC1
2orcein4610.0DES, S100B
3indium469.9CEACAM3, MUC1
43-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.8S100B, DES
5metronidazole46 1210.7MUC1, CEACAM3
6s 100469.7DES, MUC1, S100B
7dtpa469.7CEACAM3, MUC1
8ethanol46 52 25 1212.5S100B, MUC1, DES
9adriamycin469.4CEACAM3, MUC1, DES
10gold469.4DES, MUC1, CEACAM3
11ccl446 3010.4S100B, DES
12acth469.3S100B, CEACAM3, MUC1
13reticulin469.2DES, MUC1, S100B, KRT7
14hyaluronic acid46 2510.2KRT20, MUC1, DES
15methotrexate52 46 1211.2MUC1, CEACAM3, KRT7
16glycogen46 2510.2DES, MUC1, S100B, KRT7
17lactate469.1S100B, CEACAM3, DES
18thymidine46 2510.0DES, MUC1, CEACAM3, S100B
19creatinine469.0DES, MUC1, CEACAM3, S100B
20sialic acid469.0KRT7, S100B, CEACAM3, MUC1
21oxygen46 259.8DES, MUC1, CEACAM3, S100B
22retinoic acid46 259.7DES, MYH11, MUC1, S100B, KRT7
23iron46 259.7KRT20, KRT7, S100B, DES
24doxorubicin46 52 1210.7KRT20, CEACAM3, DES
25nitric oxide46 25 1210.6DES, MYH11, MUC1, CEACAM3, S100B
26glucose468.5KRT7, S100B, CEACAM3, MUC1, DES
27streptavidin468.5KRT20, KRT7, CEACAM3, DES
28formaldehyde46 259.4DES, MUC1, S100B, KRT7, KRT20
29testosterone46 62 25 1211.4DES, MUC1, S100B, KRT7, KRT20
30calcium46 52 25 1211.1DES, MUC1, CEACAM3, S100B, S100P
31b 723467.8MUC1, DES, CEACAM3, S100B, KRT20, KRT7
32mucicarmine467.8KRT20, KRT7, S100B, CEACAM3, MUC1, DES
33tyrosine467.7DES, MUC1, CEACAM3, S100B, KRT7, KRT20
34hematoxylin467.3KRT20, KRT7, S100B, CEACAM3, MUC1, MYH11
35paraffin467.3DES, MYH11, MUC1, CEACAM3, S100B, KRT7
36progesterone46 30 62 25 1211.3DES, MYH11, MUC1, CEACAM3, S100B, KRT7
37vegf467.3DES, MYH11, MUC1, CEACAM3, S100B, KRT7
38estrogen467.3DES, MYH11, MUC1, CEACAM3, S100B, KRT7

GO Terms for genes affiliated with Parachordoma

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17Gene Ontology
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Cellular components related to Parachordoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.5KRT20, KRT7, DES
2cytoplasmGO:0057377.5KRT20, KRT7, S100P, S100B, MUC1, T

Molecular functions related to Parachordoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent protein bindingGO:0483069.5S100P, S100B
2RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:0009789.5MUC1, T
3protein bindingGO:0055156.9KRT20, DES, MYH11, MUC1, S100B, S100P

Products for genes affiliated with Parachordoma

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Sources for Parachordoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet