Parachordoma malady

MalaCards: Parachordoma, also known as parachordoma (morphologic abnormality), is related to myoepithelioma and extraskeletal myxoid chondrosarcoma. An important gene associated with Parachordoma is T (T, brachyury homolog (mouse)). The compounds indium and s 100 have been mentioned in the context of this disorder.

Aliases & Descriptions:

parachordoma 6 8 43 parachordoma (morphologic abnormality) 6

parachordoma (disorder) 6

Diseases related to parachordoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 185)

id	Related Disease	Score	Top Affiliating Genes
1	myoepithelioma	28.1	DES, T
2	extraskeletal myxoid chondrosarcoma	27.2	MYH11, MUC1
3	myxoid chondrosarcoma	27.2	MYH11, MUC1
4	chordoma	26.0	MUC1, MYH11, DES, KRT20, KRT7, CEACAM3
5	chondrosarcoma	25.6	MYH11, DES, CEACAM3, T, MUC1
6	chondroid chordoma	13.1	CEACAM3, MUC1
7	spindle cell thymoma	13.1	DES, MUC1
8	fibrous meningioma	13.0	DES, MUC1
9	pericardial effusion	13.0	CEACAM3, MUC1
10	rectum sarcomatoid carcinoma	13.0	DES, MUC1
11	cutaneous leiomyosarcoma	13.0	DES, MUC1
12	mucinous cystadenocarcinoma	13.0	CEACAM3, MUC1
13	adrenal cortical carcinoma	13.0	MUC1, DES
14	hemangioma of lung	13.0	CEACAM3, MUC1
15	meninges hemangiopericytoma	13.0	DES, MUC1
16	mesenchymal chondrosarcoma	13.0	DES, MUC1
17	rhabdoid tumors	13.0	DES, MUC1
18	collecting duct carcinoma	13.0	CEACAM3, MUC1
19	malignant pleural mesothelioma	13.0	CEACAM3, MUC1
20	pleomorphic carcinoma	13.0	DES, MUC1
21	atypical teratoid rhabdoid tumor	13.0	DES, MUC1
22	glomus tumor	13.0	DES, MUC1
23	perineurioma	13.0	DES, MUC1
24	perivascular epithelioid cell tumor	13.0	DES, MUC1
25	bowen syndrome	12.9	KRT7, CEACAM3
26	granulosa cell tumor of the ovary	12.9	KRT7, CEACAM3
27	peripheral primitive neuroectodermal tumor	12.9	DES, MUC1
28	granular cell tumor	12.9	DES, CEACAM3
29	uterine carcinosarcoma	12.9	MUC1, DES
30	benign metastasizing leiomyoma	12.9	DES, KRT7
31	merkel cell carcinoma	12.9	KRT20, MUC1
32	pulmonary alveolar proteinosis	12.9	CEACAM3, MUC1
33	ovarian large-cell neuroendocrine carcinoma	12.9	KRT20, KRT7
34	sclerosing hemangioma	12.9	MUC1, CEACAM3
35	desmoplastic small round cell tumor	12.9	DES, MUC1
36	paraurethral gland neoplasm	12.9	KRT7, KRT20
37	bladder adenocarcinoma	12.9	KRT20, KRT7
38	papillary serous adenocarcinoma	12.9	KRT20, KRT7
39	signet ring cell adenocarcinoma	12.9	KRT20, KRT7
40	ovarian brenner tumor	12.9	KRT20, KRT7
41	signet ring basal cell carcinoma	12.9	KRT20, KRT7
42	myxopapillary ependymoma	12.9	KRT7, MUC1
43	ovarian mucinous adenocarcinoma	12.9	KRT20, KRT7
44	nephrogenic adenoma	12.9	KRT7, MUC1
45	mucinous ovarian cystadenoma	12.9	KRT20, KRT7
46	dermatofibrosarcoma protuberans	12.9	MUC1, DES
47	large cell carcinoma	12.8	KRT7, CEACAM3
48	secretory meningioma	12.8	MUC1, KRT7
49	papillary adenocarcinoma	12.8	KRT20, MUC1
50	horseshoe kidney	12.8	KRT20, KRT7

Approved drugs:

Drug clinical trials:

Articles related to parachordoma:

id	Title	Authors	Year	Affiliating Genes
1	Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue. (18301055)	Tirabosco R.... Flanagan A.M.	2008	T
2	Parachordoma is not distinguishable from axial chordoma using immunohistochemistry. (15086843)	Scolyer R.A.... McCarthy S.W.	2004	MUC1, KRT7, CEACAM3
3	Parachordoma is immunohistochemically and cytogenetically distinct from axial chordoma and extraskeletal myxoid chondrosarcoma. (10478665)	Folpe A.L.... Weiss S.W.	1999	MYH11
4	Cutaneous parachordoma. A light microscopic and immunohistochemical report of two cases and review of the literature. (9696295)	Imlay S.P.... Henghold W.B.	1998	MUC1
5	Parachordoma: a clinicopathologic and immunohistochemical study of four cases of an unusual soft tissue neoplasm. (9869820)	Fisher C.... Miettinen M.	1997	DES, CEACAM3
6	Parachordoma. A case report of a very rare soft tissue tumor. (8950765)	Karabela-Bouropoulou V.... Mahaira H.	1996	MUC1
7	Parachordoma--a clinicopathologic, immunohistochemica l, electron microscopic, flow cytometric, and cytogenetic study. (8542507)	Niezabitowski A.... Nedoszytko B.	1995	DES

Genes related to parachordoma according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	T	T, brachyury homolog (mouse)	11.0	Publications
2	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
3	DES	desmin	11.0	Publications
4	KRT20	keratin 20	11.0	Publications
5	KRT7	keratin 7	11.0	Publications
6	MYH11	myosin, heavy chain 11, smooth muscle	11.0	Publications
7	MUC1	mucin 1, cell surface associated	11.0	Publications

Compounds related to parachordoma according to GeneDecks:

(show all 25)

id	Compound	Score	Top Affiliating Genes
1	indium32	9.8	MUC1, CEACAM3
2	s 10032	9.8	MUC1, DES
3	metronidazole32 9 9	11.7	CEACAM3, MUC1
4	dtpa32	9.7	CEACAM3, MUC1
5	adriamycin32	9.4	DES, CEACAM3, MUC1
6	gold32	9.3	MUC1, CEACAM3, DES
7	hyaluronic acid32 18	10.2	DES, KRT20, MUC1
8	reticulin32	9.2	MUC1, KRT7, DES
9	methotrexate32 34 42 9 9	13.1	MUC1, CEACAM3, KRT7
10	doxorubicin32 34 9 9	12.0	CEACAM3, KRT20, DES
11	glycogen32 18	9.9	MUC1, KRT7, DES
12	streptavidin32	8.8	DES, KRT20, KRT7, CEACAM3
13	formaldehyde32 18	9.7	DES, KRT20, KRT7, MUC1
14	testosterone32 9 18 9	11.6	MUC1, KRT7, KRT20, DES
15	nitric oxide32 9 18 9	11.4	MUC1, CEACAM3, DES, MYH11
16	mucicarmine32	8.3	DES, KRT20, KRT7, CEACAM3, MUC1
17	b 72332	8.3	DES, KRT20, KRT7, CEACAM3, MUC1
18	glucose32	8.2	DES, KRT7, CEACAM3, MUC1
19	retinoic acid32 42 18	10.1	MYH11, DES, KRT7, MUC1
20	tyrosine32	8.0	DES, KRT20, KRT7, CEACAM3, MUC1
21	hematoxylin32	7.5	MUC1, CEACAM3, KRT7, KRT20, DES, MYH11
22	paraffin32	7.5	MYH11, DES, KRT20, KRT7, CEACAM3, MUC1
23	progesterone32 42 9 18 9	11.5	MYH11, DES, KRT20, KRT7, CEACAM3, MUC1
24	vegf32	7.5	MYH11, DES, KRT20, KRT7, CEACAM3, MUC1
25	estrogen32	7.4	MYH11, DES, KRT20, KRT7, CEACAM3, MUC1

Cellular components related to parachordoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:005882	8.9	KRT7, KRT20, DES