PCM
MCID: PRC002
MIFTS: 70

Paracoccidioidomycosis (PCM) malady

Infectious diseases, Immune diseases categories

Summaries for Paracoccidioidomycosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in paracoccidioides brasiliensis.

MalaCards: Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to thyroiditis and malaria. An important gene associated with Paracoccidioidomycosis is CXCL10 (chemokine (C-X-C motif) ligand 10), and among its related pathways are Cell adhesion molecules (CAMs) and Regulation by c-FLIP. The drugs ketoconazole and itraconazole and the compounds cyclosporin a and rantes have been mentioned in the context of this disorder. Affiliated tissues include skin or, bone and lymph nodes, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Wikipedia:63 Paracoccidioidomycosis (also known as \"Brazilian blastomycosis,\" \"South American... more...

Aliases & Classifications for Paracoccidioidomycosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Immune diseases


Characteristics (Orphanet epidemiological data):

48
paracoccidioidomycosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

paracoccidioidomycosis 8 42 44 48 60
mucocutaneous-lymphangitic paracoccidioidomycosis 8
paracoccidioidomycosis, unspecified 8
lutz-splendore-almeida disease 42
south american blastomycosis 42
protein-energy malnutrition 60
paracoccidioidomycosis nos 8
paracoccidioidal granuloma 42
paracoccidioidal mycosis 8
lobo disease 42
pcm 42


External Ids:

Disease Ontology8 DOID:12662
NCIt39 C34891
MeSH34 D010229
ICD9CM27 116.1
ICD10 via Orphanet26 B41.7, B41.8, B41.9 B41.0, more
MESH via Orphanet35 D010229
SNOMED-CT via Orphanet57 59925007
UMLS via Orphanet61 C0030409
ICD1025 B41, B41.9

Related Diseases for Paracoccidioidomycosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 224)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.9FASLG, CTLA4
2malaria30.8GSR, TPI1, IL10, CXCL9, G6PD, HSPD1
3ischemia30.7GSR
4cystic fibrosis30.4TLR4
5leukemia30.4TNFRSF1A, GLO1, FASLG, TLR4
6tuberculosis30.4GSR, TPI1, IL10, CXCL9, CXCL10, MYD88
7dilated cardiomyopathy30.2HSPD1
8meningitis30.2CXCL10
9influenza30.2CD28, CXCL10, MYD88, CXCL9
10deficiency anemia30.2TPI1, GSR, G6PD
11viral hepatitis30.2FASLG, G6PD, TNFRSF1A
12leishmaniasis30.2TNFRSF1A, GLO1, IL10, IL5
13alzheimer's disease30.2GLO1, TPI1, GSR, TNFRSF1A
14tetanus30.2HSPD1, IL10, IL5, CD28
15inflammatory bowel disease30.2HSPD1, TLR4, IL10, TNFRSF1A, CTLA4, CXCL10
16hepatitis30.1GSR, CXCL10, FASLG, TNFRSF1A
17squamous cell carcinoma30.1FASLG, CTLA4, GLO1, CKS1B, TPI1, CXCL9
18cervicitis30.0HSPD1
19gingivitis30.0HSPD1
20esophagitis30.0IL5
21pancreatitis29.8IL10
22vasculitis29.8HSPD1, CTLA4
23colon cancer29.8HSPD1, FASLG
24silicosis29.8FASLG
25sarcoidosis29.8CD28, CXCL10, CXCL9, IL12RB2
26schistosomiasis29.8IL10, GSR, IL5
27periodontitis29.8HSPD1, TLR4, IL10
28pneumonia29.8IL5, IL10, MYD88, CXCL10, TLR4
29hepatitis c29.8IL10, CXCL10, CD28, CTLA4, TLR4, GSR
30prostate cancer29.8FASLG, GSR, TPI1, CXCL10, GLO1, CTLA4
31arthritis29.8CTLA4, TNFRSF1A, TLR4, HSPD1, CXCL10, CXCL9
32lung cancer29.8TLR4, HSPD1, TNFRSF1A, GSR, CTLA4, GLO1
33rheumatoid arthritis29.8CXCL10, FASLG, PDCD1, CXCL9, HSPD1, TLR4
34protein-energy malnutrition11.5
35kwashiorkor10.6
36marasmus10.5
37liver cirrhosis10.5
38peritonitis10.5
39cerebritis10.4
40measles10.4
41blastomycosis10.3
42biotin deficiency10.3
43lactose intolerance10.3
44cerebral malaria10.3
45acute leukemia10.3
46neuroblastoma10.3
47histoplasmosis10.3
48burns10.2
49acute diarrhea10.2
50visceral leishmaniasis10.2

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to paracoccidioidomycosis

Clinical Features for Paracoccidioidomycosis

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Drugs & Therapeutics for Paracoccidioidomycosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Paracoccidioidomycosis

Search NIH Clinical Center for Paracoccidioidomycosis

Search CenterWatch for Paracoccidioidomycosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Paracoccidioidomycosis

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Anatomical Context for Paracoccidioidomycosis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Paracoccidioidomycosis:

32
Bone, Lung, Skin, Lymph node, T cells, Testes, Monocytes, Bone marrow, Prostate, Adrenal gland, Myeloid, B cells, Colon, Spinal cord, Thymus, Spleen

FMA organs/tissues related to Paracoccidioidomycosis:

14
Skin or, Bone, Lymph nodes, Mucosa

Animal Models for Paracoccidioidomycosis or affiliated genes

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36MGI
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Publications for Paracoccidioidomycosis

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50PubMed
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Articles related to Paracoccidioidomycosis:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
The left lung is preferentially targeted during experimental paracoccidioidomycosis in C57BL/6 mice. (24141611)
2013
2
DNA vaccine encoding peptide P10 against experimental paracoccidioidomycosis induces long-term protection in presence of regulatory T cells. (23201596)
2013
3
Osteomyelitis and pyoarthritis resulting from local paracoccidioidomycosis in an immunocompetent patient: a case report. (23043817)
2012
4
Effects of pretreating serum samples on the performance of a latex agglutination test for serodiagnosis of paracoccidioidomycosis. (22205661)
2012
5
Radiologic findings of osteoarticular infection in paracoccidioidomycosis. (21643938)
2012
6
Profile of total IgG, IgG1, IgG2, IgG3 and IgG4 levels in sera of patients with paracoccidioidomycosis: treatment follow-up using Mexo and rPb27 as antigens in an ELISA. (22310529)
2012
7
Paracoccidioidomycosis: sarcoid-like form in childhood. (22714772)
2012
8
Serological survey of Paracoccidioidomycosis in sheep. (21850559)
2012
9
Paracoccidioidomycosis in the state of MaranhALo, Brazil: geographical and clinical aspects. (22760141)
2012
10
Chronic pulmonary paracoccidioidomycosis in an AIDS patient and Mycobacterium gordonae as confounding factor. (21412599)
2011
11
Images in infectious diseases. Concomitant progressive multifocal leukoencephalopathy and disseminated paracoccidioidomycosis in an AIDS patient. (21181044)
2010
12
Paracoccidioidomycosis in a Spanish missionary. (20412183)
2010
13
Spontaneous pneumothorax as an atypical presentation of pulmonary paracoccidioidomycosis: a case report with emphasis on the imaging findings. (20592996)
2010
14
Humoral response of paracoccidioidomycosis sera in hamsters with different Venezuelan isolates. (19928450)
2009
15
Epidemiological study of paracoccidioidomycosis and histoplasmosis in a suburb of San FAclix city, BolA-var state, Venezuela. (19662816)
2009
16
Serum proteins and fractions, HDL-cholesterol and total IgG and IgE levels in cases of acute and chronic paracoccidioidomycosis. (19684969)
2009
17
Role of interleukin (IL)-18 in experimental paracoccidioidomycosis. (18608933)
2008
18
Toll-like receptors and fungal infections: the role of TLR2, TLR4 and MyD88 in paracoccidioidomycosis. (18384366)
2008
19
Involvement of extracellular matrix proteins in the course of experimental paracoccidioidomycosis. (18400008)
2008
20
Analysis of memory T cells in the human paracoccidioidomycosis before and during chemotherapy treatment. (17897724)
2007
21
Kinetics of IFN-gamma, TNF-alpha, IL-10 and IL-4 production by mononuclear cells stimulated with gp43 peptides, in patients cured of paracoccidioidomycosis. (17568881)
2007
22
Expression of antibodies directed to Paracoccidioides brasiliensis glycosphingolipids during the course of paracoccidioidomycosis treatment. (17135452)
2007
23
Paracoccidioidomycosis in wild monkeys from ParanA! State, Brazil. (17914662)
2007
24
Diagnosis of three cases of paracoccidioidomycosis by fine needle aspiration cytology. (17397500)
2007
25
A case of imported paracoccidioidomycosis: an awkward infection in The Netherlands. (16805088)
2006
26
Cytokeratin expression in pseudoepitheliomatous hyperplasia of oral paracoccidioidomycosis. (16882606)
2006
27
Central nervous system paracoccidioidomycosis: an overview. (16127588)
2005
28
Paracoccidioides brasiliensis exoantigens: recognition by IgG from patients with different clinical forms of paracoccidioidomycosis. (14623016)
2003
29
Negative immunodiffusion test results obtained with sera of paracoccidioidomycosis patients may be related to low-avidity immunoglobulin G2 antibodies directed against carbohydrate epitopes. (12965908)
2003
30
Evaluation of fungal burden in experimental paracoccidioidomycosis by using the fluorescent dye Blankophor. (12843109)
2003
31
Paracoccidioidomycosis: report of 2 cases mimicking squamous cell carcinoma. (12424456)
2002
32
Oral exfoliative cytology in the diagnosis of paracoccidioidomycosis. (11393067)
2001
33
Imbalance of IL-2, IFN-gamma and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis. (11237434)
2001
34
DNA-based vaccination against murine paracoccidioidomycosis using the gp43 gene from paracoccidioides brasiliensis. (10825609)
2000
35
Depletion of CD8(+) T cells in vivo impairs host defense of mice resistant and susceptible to pulmonary paracoccidioidomycosis. (10603408)
2000
36
Isolation of Paracoccidioides brasiliensis from the nine-banded armadillo Dasypus novemcinctus, in an endemic area for paracoccidioidomycosis in Colombia. (18473551)
1999
37
Chronic pulmonary paracoccidioidomycosis (South American blastomycosis): high-resolution CT findings in 41 patients. (10397100)
1999
38
A case report of intraspinal paracoccidioidomycosis. (9830738)
1998
39
Aspergillus fumigatus fungus ball in a patient with healed paracoccidioidomycosis. (9431402)
1997
40
Isolation of fungi from nature in the region of Botucatu, state of SALo Paulo, Brazil, an endemic area of paracoccidioidomycosis. (9283642)
1996
41
Lack of reactivity of paracoccidioidomycosis sera in the double immunodiffusion test with the gp43 antigen: report of two cases. (7658301)
1995
42
Comparative ultrastructure and immunolabeling of MHC-II antigens of alveolar macrophages obtained from patients with paracoccidioidomycosis and other lung diseases. (7829961)
1995
43
Severe acute paracoccidioidomycosis in children. (8078739)
1994
44
Paracoccidioidomycosis and its etiologic agent Paracoccidioides brasiliensis. (8509955)
1993
45
Diagnosis of paracoccidioidomycosis by passive haemagglutination assay of antibody using a purified and specific antigen-gp43. (8509952)
1993
46
Advances in experimental paracoccidioidomycosis using an isogenic murine model. (8298272)
1993
47
Antigenemia in paracoccidioidomycosis. (1537906)
1992
48
Specific recognition pattern of IgM and IgG antibodies produced in the course of experimental paracoccidioidomycosis. (1563097)
1992
49
Immunodeficiency secondary to juvenile paracoccidioidomycosis: associated infections. (1480206)
1992
50
Respiratory cytopathology: paracoccidioidomycosis associated either with tuberculosis or bronchogenic carcinoma. (1568417)
1992

Genetic Variations for Paracoccidioidomycosis

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Expression for genes affiliated with Paracoccidioidomycosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for genes affiliated with Paracoccidioidomycosis

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Sources:
29KEGG, 53Reactome, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2PDCD1, ICOS
2
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10.2TNFRSF1A, FASLG
3
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10.0IL10, FASLG, TNFRSF1A
410.0TLR4, MYD88, CXCL10
510.0FASLG, MYD88, IL10
610.0IL10, MYD88, TLR4
710.0IL10, MYD88, TLR4
8
Hide members
10.0IL5, CTLA4, FASLG
910.0MYD88, TNFRSF1A, TLR4
1010.0MYD88, TNFRSF1A, TLR4
1110.0HSPD1, TLR4, MYD88
1210.0HSPD1, FASLG, IL5
1310.0IL5, CD28, TNFRSF1A
1410.0CD28, CTLA4, TLR4
15
Immune response Bacterial infections in normal airways
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9.9MYD88, FASLG, TLR4
16
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9.9ICOS, PDCD1, CTLA4, CD28
17
Hide members
9.8CD28, CXCL10, IL12RB2, IL5
18
Hide members
9.8TLR4, TNFRSF1A, FASLG, MYD88
199.8TLR4, TNFRSF1A, MYD88, CD28
20
Hide members
9.8IL10, IL12RB2, CD28, TLR4
219.8HSPD1, TLR4, TNFRSF1A, MYD88, IL10
22
Hide members
9.7ICOS, PDCD1, CTLA4, CD28, IL5
23
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9.6TLR4, TNFRSF1A, MYD88, IL12RB2, IL10, IL5
24
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9.5TLR4, TNFRSF1A, FASLG, MYD88, CD28, CXCL10
25
Hide members
9.4TLR4, TNFRSF1A, FASLG, MYD88, CXCL10, CXCL9
26
Hide members
9.4TNFRSF1A, CD28, CXCL10, CXCL9, IL12RB2, IL10
27
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9.3TLR4, ICOS, PDCD1, CTLA4, MYD88, CD28
28
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9.1IL5, HSPD1, ICOS, TNFRSF1A, FASLG, CTLA4
29
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9.1TLR4, TNFRSF1A, FASLG, CD28, CXCL10, CXCL9
30
Hide members
9.0TLR4, TNFRSF1A, MYD88, CD28, CXCL10, CXCL9

Compounds for genes affiliated with Paracoccidioidomycosis

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1cyclosporin a44 28 5912.6CTLA4, CD28
2rantes4410.4TLR4, TNFRSF1A, FASLG
3glucose4410.4GLO1, FASLG, TPI1
4indomethacin44 59 28 1113.4GLO1, IL5, HSPD1
5infliximab44 49 1112.3IL10, TLR4, TNFRSF1A, CXCL10
6endotoxin4410.3TNFRSF1A, HSPD1, FASLG, MYD88
7cycloheximide4410.3HSPD1, CXCL10, FASLG
8aspartate4410.3FASLG, G6PD, HSPD1, TPI1
9glutamate4410.3TPI1, GLO1, TNFRSF1A, HSPD1
10con a4410.2IL5, IL10, CTLA4, CD28
11polyinosinic-polycytidylic acid4410.2IL5, IL10, CXCL10, TLR4
12imiquimod44 28 59 1113.2FASLG, IL10, IL5, TLR4
13oxygen44 2411.2CD28, TNFRSF1A, MYD88
14thalidomide44 49 59 1113.1TNFRSF1A, FASLG, CTLA4, IL5, IL10
15manganese superoxide4410.1GSR, TPI1, FASLG, TNFRSF1A, HSPD1
16tarc4410.1IL10, IL5, CXCL10, CXCL9
17glatiramer acetate44 1111.1CTLA4, IL10, IL5
18ifn-alpha4410.1FASLG, TLR4, CXCL10, CXCL9, IL10
19dexamethasone44 49 28 1113.1CXCL9, CTLA4, FASLG, TLR4, IL5
20h2o24410.1G6PD, FASLG, TNFRSF1A, HSPD1
21allergens4410.0TLR4, PDCD1, CTLA4, CXCL10, IL10, IL5
22ivig4410.0IL10, TNFRSF1A, IL5, FASLG
23il 104410.0CXCL9, IL10, IL5, TLR4, CXCL10, CTLA4
24chloroquine44 2 49 28 1114.0G6PD, TNFRSF1A, CXCL10, IL10, GSR, TLR4
25tgf beta14410.0IL10, TNFRSF1A, FASLG, CTLA4, TLR4
26ccl344 2811.0CXCL10, TLR4, CXCL9, IL10
27methylglyoxal44 2810.9GLO1, GSR, TPI1
28glyceraldehyde 3-phosphate449.9G6PD, HSPD1, TLR4, GLO1, TPI1, GSR
29methotrexate44 49 1111.9FASLG, TNFRSF1A, CTLA4, GLO1, IL5, GSR
30cyclophosphamide44 49 1111.9FASLG, G6PD, IL10, GSR, CXCL9
31n acetylcysteine449.8G6PD, FASLG, TNFRSF1A, GSR, HSPD1, TLR4
32tacrolimus44 49 1111.8CTLA4, CD28, CXCL10, IL10, IL5, FASLG
33ionomycin449.8IL10, IL5, CXCL9, CD28, CTLA4, FASLG
34superoxide44 2410.8TPI1, HSPD1, GSR, GLO1, G6PD, TNFRSF1A
35doxorubicin44 49 1111.8TNFRSF1A, HSPD1, GSR, GLO1, G6PD, FASLG
36ly294002449.7CTLA4, IL5, IL10, FASLG, TLR4, MYD88
37lactate449.7G6PD, GLO1, TPI1, HSPD1, FASLG, GSR
38creatinine449.7GLO1, HSPD1, TNFRSF1A, GSR, G6PD, TPI1
39adenylate449.7CXCL10, GLO1, IL5, FASLG, G6PD, TPI1
40alanine449.6FASLG, TNFRSF1A, TLR4, HSPD1, CXCL10, GLO1
41vegf449.6CXCL9, HSPD1, TNFRSF1A, FASLG, CXCL10, IL10
42guanidine hydrochloride449.6GSR, TPI1, G6PD, HSPD1
43nitric oxide44 11 2411.6TLR4, FASLG, MYD88, IL10, CXCL9, GLO1
44cholesterol44 28 11 2412.6CXCL10, HSPD1, TNFRSF1A, FASLG, TLR4, CTLA4
45atp44 2810.5MYD88, TLR4, HSPD1, TNFRSF1A, CXCL9, CXCL10
46phosphatidylinositol449.5HSPD1, TLR4, CD28, TNFRSF1A, FASLG, CXCL9
47genistein44 28 59 2 11 2414.4CXCL10, CD28, TLR4, FASLG, IL5, GSR
48cysteine449.3TNFRSF1A, GSR, IL5, CD28, GLO1, CTLA4
49lipid449.2GLO1, CXCL10, TPI1, GSR, CD28, MYD88
50tyrosine448.7TPI1, IL12RB2, CKS1B, HSPD1, CXCL9, PDCD1

GO Terms for genes affiliated with Paracoccidioidomycosis

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16Gene Ontology
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Cellular components related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor complexGO:04669610.2TLR4, HSPD1
2extracellular spaceGO:0056159.3HSPD1, TNFRSF1A, FASLG, CXCL10, CXCL9, IL10
3integral to plasma membraneGO:0058879.1TLR4, ICOS, TNFRSF1A, FASLG, CTLA4, CD28
4external side of plasma membraneGO:0098979.0IL12RB2, TLR4, ICOS, PDCD1, FASLG, CTLA4

Biological processes related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.3IL10, TLR4
2negative regulation of interleukin-6 productionGO:03271510.3TLR4, TNFRSF1A, IL10
3positive regulation of interferon-gamma productionGO:03272910.3IL12RB2, TLR4, HSPD1
4interferon-gamma productionGO:03260910.3TLR4, IL12RB2
5positive regulation of interleukin-6 productionGO:03275510.3HSPD1, TLR4, MYD88
6negative regulation of B cell proliferationGO:03088910.2IL10, CTLA4
7glutathione metabolic processGO:00674910.2G6PD, GLO1, GSR
8cellular response to mechanical stimulusGO:07126010.2MYD88, TNFRSF1A, TLR4
9T cell costimulationGO:03129510.2CD28, CTLA4, PDCD1, ICOS
10positive regulation of interferon-alpha productionGO:03272710.2HSPD1, TLR4
11pentose-phosphate shuntGO:00609810.1G6PD, TPI1
12cell surface receptor signaling pathwayGO:00716610.1MYD88, CD28, CXCL10, IL12RB2
13MyD88-dependent toll-like receptor signaling pathwayGO:00275510.1HSPD1, TLR4, MYD88
14positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.1MYD88, FASLG, TNFRSF1A, TLR4
15response to lipopolysaccharideGO:03249610.0TLR4, TNFRSF1A, FASLG, CXCL10, IL12RB2
16cell-cell signalingGO:00726710.0IL10, CXCL9, CXCL10, FASLG
17B cell proliferationGO:0421009.9IL10, HSPD1
18inflammatory responseGO:0069549.9TNFRSF1A, MYD88, CXCL10, CXCL9, IL10, IL5
19immune responseGO:0069559.7IL5, CXCL9, CXCL10, CTLA4, FASLG, ICOS

Molecular functions related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.8IL5, IL10, CXCL9, FASLG
2protein bindingGO:0055157.8TPI1, HSPD1, CKS1B, EXOSC3, TLR4, PDCD1

Products for genes affiliated with Paracoccidioidomycosis

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  • Antibodies
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Sources for Paracoccidioidomycosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet