MCID: PRC002
MIFTS: 56

Paracoccidioidomycosis malady

Categories: Rare diseases, Infectious diseases, Immune diseases, Bone diseases, Skin diseases

Aliases & Classifications for Paracoccidioidomycosis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Paracoccidioidomycosis:

Name: Paracoccidioidomycosis 10 45 47 12 51 36 65
Mucocutaneous-Lymphangitic Paracoccidioidomycosis 10
Paracoccidioidomycosis, Unspecified 10
Lutz-Splendore-Almeida Disease 45
South American Blastomycosis 45
Paracoccidioidomycosis Nos 10
 
Paracoccidioidal Granuloma 45
Paracoccidioidal Mycosis 10
Lobo Disease 45
Lobomycosis 65
Pcm 45

Characteristics:

Orphanet epidemiological data:

51
paracoccidioidomycosis:
Inheritance: Not applicable; Age of onset: All ages

Classifications:



External Ids:

Disease Ontology10 DOID:12662
ICD1027 B41, B41.9
ICD9CM29 116.1
MeSH36 D010229
NCIt42 C34891
Orphanet51 73260
ICD10 via Orphanet28 B41.0, B41.7, B41.8 B41.9, more
MESH via Orphanet37 D010229
UMLS via Orphanet66 C0030409
UMLS65 C0030409

Summaries for Paracoccidioidomycosis

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Disease Ontology:10 A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in Paracoccidioides brasiliensis.

MalaCards based summary: Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to sjogren's syndrome and achalasia. An important gene associated with Paracoccidioidomycosis is IL10 (Interleukin 10), and among its related pathways are Canonical NF-kappaB pathway and IL4-mediated signaling events. The drugs itraconazole and ketoconazole have been mentioned in the context of this disorder. Affiliated tissues include mucosa, lymph nodes and bone, and related mouse phenotypes are vision/eye and respiratory system.

Wikipedia:68 Paracoccidioidomycosis (also known as \"Brazilian blastomycosis,\" \"South American... more...

Related Diseases for Paracoccidioidomycosis

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Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 556)
idRelated DiseaseScoreTop Affiliating Genes
1sjogren's syndrome30.3CD40LG, TNF
2achalasia30.2IL10, IL4, TNF
3dermatitis30.2ALB, CD40LG
4lateral sclerosis30.1CD40LG, IL10, TNF
5bronchopulmonary dysplasia30.0IFNG, IL10, TNF
6collagenous colitis30.0IFNG, IL4, TNF
7miliary tuberculosis30.0CTLA4, IFNG, TNF
8ossifying fibroma29.9ALB, CD40LG, POMC
9peritoneal mesothelioma29.9CD40LG, TNF, TNFRSF1A
10hemolytic anemia29.8CTLA4, IFNG, IL10, TNF
11hyperglycemia29.8ALB, POMC, TNF
12rheumatoid arthritis29.1CD40LG, CTLA4, IFNG, IL10, IL4, TNF
13systemic lupus erythematosus28.9ALB, CD40LG, CTLA4, IFNG, IL10, TNF
14malaria28.0ALB, CD40LG, IFNG, IL10, IL4, MYD88
15punctate palmoplantar keratoderma type 210.5IL10, TNF
16multifocal lymphangioendotheliomatosis with thrombocytopenia10.5IL10, TNF
17alternating exotropia10.5IL10, TNF
18autoimmune polyglandular syndrome type 210.5CTLA4, TNF
19oropouche fever10.5CD40LG, IL10
20erdheim-chester disease10.5CD40LG, TNF
21androgen insensitivity syndrome, mild10.5CTLA4, TNF
22drug-induced mental disorder10.5IL10, TNF
23penicillin allergy10.4IL10, IL4
24brucella melitensis brucellosis10.4CD40LG, TNF
25lateral displacement of eye10.4CD40LG, POMC
26rhinoscleroma10.4CD40LG, TNF
27posterior scleritis10.4CD40LG, POMC
28superficial urinary bladder cancer10.4IL10, IL4
29benign paroxysmal positional nystagmus10.4CTLA4, IL4
30autoimmune oophoritis10.4IFNG, TNF
31non-distal monosomy 10q10.4IFNG, TNF
32craniofacioskeletal syndrome10.4CD40LG, IL4
33graft-versus-host disease, protection against10.4IFNG, IL10
34ethmoid sinus squamous cell carcinoma10.4IFNG, TNF
35alpha chain disease10.4CD40LG, MYD88
36generalized atherosclerosis10.4CD40LG, MYD88
37primary progressive freezing gait10.4IL10, IL4, TNF
38beriberi10.4CD40LG, IFNG
39moderately severe hemophilia a10.4CTLA4, IL10, TNF
40kearns-sayre syndrome10.4IL10, IL4, TNF
41parasitic ichthyosporea infectious disease10.3IFNG, TNF
42progressive relapsing multiple sclerosis10.3CTLA4, IL10, TNF
43bacillary angiomatosis10.3CD40LG, IFNG
44goat milk allergy10.3IL10, IL4, TNF
45multiple sclerosis 510.3TNF, TNFRSF1A
46limbic encephalitis with ncmags antibodies10.3IFNG, IL4
47chronic demyelinizing neuropathy with igm monoclonal10.3IFNG, IL10
48methylmalonic acidemia10.3IL10, IL4, TNF
49kernicterus due to isoimmunization10.3CD40LG, IL10, TNF
50kohler's disease10.3IL10, IL4, TNF

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to paracoccidioidomycosis

Symptoms for Paracoccidioidomycosis

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Drugs & Therapeutics for Paracoccidioidomycosis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Paracoccidioidomycosis

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: paracoccidioidomycosis

Genetic Tests for Paracoccidioidomycosis

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Anatomical Context for Paracoccidioidomycosis

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MalaCards organs/tissues related to Paracoccidioidomycosis:

33
Bone, Skin, Lymph node, Lung, Endothelial, Thyroid, Liver

FMA organs/tissues related to Paracoccidioidomycosis:

16
Mucosa, Lymph nodes, Bone, Skin or

Animal Models for Paracoccidioidomycosis or affiliated genes

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MGI Mouse Phenotypes related to Paracoccidioidomycosis:

38 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5IFNG, IL10, IL4, MYD88, TNF, TNFRSF1A
2MP:00053888.3CTLA4, IFNG, IL10, IL4, MYD88, TNF
3MP:00053898.2CD40LG, IFNG, IL10, IL4, MYD88, TNF
4MP:00030128.2IFNG, IL10, IL4, MYD88, POMC, TNF
5MP:00107718.0CD40LG, CTLA4, IFNG, IL10, IL4, POMC
6MP:00020068.0ALB, IFNG, IL10, MYD88, POMC, TNF
7MP:00053707.8ALB, CTLA4, IFNG, IL10, IL4, POMC
8MP:00036317.8CD40LG, IFNG, IL10, IL4, MYD88, POMC
9MP:00053677.7ALB, CD40LG, IFNG, IL4, MYD88, POMC
10MP:00053817.6ALB, CTLA4, IFNG, IL10, IL4, MYD88
11MP:00053907.6CD40LG, CTLA4, IFNG, IL10, IL4, MYD88
12MP:00053857.5CD40LG, CTLA4, IFNG, IL10, MYD88, POMC
13MP:00053847.1ALB, CD40LG, IFNG, IL10, IL4, MYD88
14MP:00053797.0ALB, CD40LG, CTLA4, IFNG, IL10, IL4
15MP:00053876.3CD40LG, CTLA4, IFNG, IL10, IL4, MYD88
16MP:00053976.1CD40LG, CTLA4, IFNG, IL10, IL4, MYD88
17MP:00107685.9ALB, CD40LG, CTLA4, IFNG, IL10, IL4
18MP:00053765.4ALB, CD40LG, CTLA4, GLO1, IFNG, IL10

Publications for Paracoccidioidomycosis

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Articles related to Paracoccidioidomycosis:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
Mucinous cystadenoma of a horseshoe kidney: A case report and literature review. (25624964)
2015
2
Perioperative normovolemic hemodilution in a case of leiomyomatous erythrocytosis. (25161358)
2014
3
Pressure-assisted dissociation and degradation of "proteinase K-resistant" fibrils prepared by seeding with scrapie-infected hamster prion protein. (25248142)
2014
4
Increased concentration of C-reactive protein in obese patients with type 2 diabetes is associated with obesity and presence of diabetes but not with macrovascular and microvascular complications or glycemic control. (24197824)
2014
5
Chordoid meningioma in a pediatric patient with tuberous sclerosis complex. (25214863)
2014
6
New insights into the protective power of platelets in malaria infection. (23710276)
2013
7
A promise in the treatment of endometriosis: an observational cohort study on ovarian endometrioma reduction by N-acetylcysteine. (23737821)
2013
8
Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage. (23910567)
2013
9
Is laparoscopic re-evaluation justified in cryptorchidism with previous negative open exploration? (22168768)
2012
10
Outbreak of Mycobacterium mucogenicum bloodstream infections among patients with sickle cell disease in an outpatient setting. (23041812)
2012
11
High myopia as a risk factor in primary open angle glaucoma. (23275912)
2012
12
Extent II repair of thoracoabdominal aortic aneurysm secondary to chronic dissection. (23977525)
2012
13
Comparison between laparoscopy and noninvasive tests for the diagnosis of tuberculous peritonitis. (21882025)
2011
14
Pheochromocytoma presenting as recurrent urinary tract infections : a case report. (21226896)
2011
15
Linear cutaneous lupus erythematosus on the midline of the face. (21352282)
2011
16
Thyrotoxic periodic paralysis. (21966655)
2011
17
IRREGULAR TRICHOME BRANCH 2 (ITB2) encodes a putative aminophospholipid translocase that regulates trichome branch elongation in Arabidopsis. (19566596)
2009
18
Dosing lepirudin in patients with heparin-induced thrombocytopenia and normal or impaired renal function: a single-center experience with 68 patients. (19059879)
2009
19
Bilateral pulmonary contusion, flail chest and respiratory failure on late iatrogenic diaphragmatic eventration and severe kyphoskoliosis: a case report. (19040741)
2008
20
Takayasu's arteritis mimicking aortic intramural hematoma in a female patient with chest pain. (18935716)
2008
21
Speciation analysis of selected metals and determination of their total contents in paired serum and cerebrospinal fluid samples: An approach to investigate the permeability of the human blood-cerebrospinal fluid-barrier. (18809082)
2008
22
Methods for kinetic and thermodynamic analysis of aminoacyl-tRNA synthetases. (18241792)
2008
23
18F-FDG PET and PET/CT in fever of unknown origin. (17204697)
2007
24
Chronic stimulation of Nod2 mediates tolerance to bacterial products. (18032608)
2007
25
Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element. (16210365)
2006
26
Neuroendocrine, cognitive and structural imaging characteristics of women on longterm sickleave with job stress-induced depression. (16934773)
2006
27
Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases. (16611982)
2006
28
The cytoplasmic domain of NrCAM binds to PDZ domains of synapse-associated proteins SAP90/PSD95 and SAP97. (16882004)
2006
29
Paralytic ileus: a complication after intrathecal baclofen therapy. (17378237)
2006
30
Galphaq-coupled receptor signaling enhances adenylate cyclase type 6 activation. (15885660)
2005
31
A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors. (14699136)
2004
32
Impaired calmodulin binding of myosin-7A causes autosomal dominant hearing loss (DFNA11). (15300860)
2004
33
Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol. (15217973)
2004
34
Identification of putative rat ribonuclease III by differential display: a novel rat mRNA expressed in a circadian manner in the rat suprachiasmatic nucleus. (15530651)
2004
35
Induction of human gamma globin gene expression by histone deacetylase inhibitors. (12920038)
2004
36
Effect of dose on immune response in patients vaccinated with an her-2/neu intracellular domain protein--based vaccine. (15143085)
2004
37
Myxosarcoma of the right ventricle: an immunohistochemical and ultrastructural study. (12926105)
2003
38
Autonomic nervous system dysfunction involving the gastrointestinal and the urinary tracts in primary SjAPgren's syndrome. (14740447)
2003
39
Antiprothrombin antibodies are associated with pregnancy loss in patients with the antiphospholipid syndrome. (12733594)
2003
40
ECM regulates MT1-MMP localization with beta1 or alphavbeta3 integrins at distinct cell compartments modulating its internalization and activity on human endothelial cells. (12427871)
2002
41
Karyopherins and nuclear import. (11751052)
2001
42
Equal symptomatic outcome after antibacterial treatment of acute lower urinary tract infection and the acute urethral syndrome in adult women. (10555247)
1999
43
Site-directed spin-labeling study of the structure and subunit interactions along a conserved sequence in the alpha-crystallin domain of heat-shock protein 27. Evidence of a conserved subunit interface. (9398181)
1997
44
A statistical analysis of the reliability and classification error in application of the mutagen sensitivity assay. (8833619)
1996
45
Re: "Epidemiology of gallstone disease in Italy: prevalence data of the Multicenter Italian Study on Cholelithiasis (M.I.COL.)". (7653477)
1995
46
Neuroborreliosis in the etiology of vestibular neuronitis. (8470505)
1993
47
Potential usefulness of combined thromboxane A2 and serotonin receptor blockade for preventing the conversion from chronic to acute coronary artery disease syndromes. (2146868)
1990
48
T-cell lymphoma, tropical spastic paraparesis, and malignant fibrous histiocytoma in a patient with human T-cell lymphotropic virus, type 1. (2536259)
1989
49
Further observations on the first documented outbreak of trichinosis in Hong Kong. (3798532)
1986
50
Observations on the bovine hemorrhagic disease caused by trichloroethylene-processed soybean oil meal. (13022565)
1953

Variations for Paracoccidioidomycosis

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Expression for genes affiliated with Paracoccidioidomycosis

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Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for genes affiliated with Paracoccidioidomycosis

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Pathways related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show all 39)
idSuper pathwaysScoreTop Affiliating Genes
19.7TNF, TNFRSF1A
29.5CD40LG, IL10, IL4
39.5IL10, MYD88, TNF
49.5IFNG, IL10, TNF
59.5IFNG, IL10, TNF
6
Show member pathways
9.5IFNG, IL10, TNF
79.4CTLA4, IFNG, TNF
89.4IFNG, IL10, IL4
99.4IFNG, IL10, IL4
109.4IFNG, IL4, TNF
119.3IFNG, IL4, POMC
12
Show member pathways
9.3CD40LG, TNF, TNFRSF1A
139.3POMC, TNF, TNFRSF1A
149.2MYD88, TNF, TNFRSF1A
159.2IFNG, TNF, TNFRSF1A
16
Show member pathways
9.2IFNG, TNF, TNFRSF1A
179.1IFNG, IL10, IL4, TNF
189.1IFNG, IL10, IL4, TNF
199.1IFNG, IL10, IL4, TNF
20
Show member pathways
9.1IFNG, IL10, IL4, TNF
21
Show member pathways
9.1ALB, IFNG, TNF
229.0IFNG, IL10, MYD88, TNF
23
Show member pathways
9.0IFNG, IL4, MYD88, TNF
249.0CD40LG, CTLA4, IL10, IL4, TNF
25
Show member pathways
8.9IFNG, IL10, TNF, TNFRSF1A
26
Show member pathways
8.9CD40LG, MYD88, TNF, TNFRSF1A
278.9CD40LG, MYD88, TNF, TNFRSF1A
28
Show member pathways
8.9CD40LG, MYD88, TNF, TNFRSF1A
29
Show member pathways
8.9CD40LG, IFNG, TNF, TNFRSF1A
308.8CD40LG, IFNG, IL4, TNFRSF1A
31
Show member pathways
8.8CD40LG, CTLA4, IFNG, IL4, TNF
328.7CD40LG, IFNG, IL10, MYD88, TNF
33
Show member pathways
8.5IFNG, IL10, MYD88, TNF, TNFRSF1A
348.5IFNG, IL10, MYD88, TNF, TNFRSF1A
35
Show member pathways
8.5IFNG, IL10, MYD88, TNF, TNFRSF1A
36
Show member pathways
8.5IFNG, IL4, MYD88, TNF, TNFRSF1A
37
Show member pathways
8.3CD40LG, IL10, IL4, MYD88, TNF, TNFRSF1A
38
Show member pathways
8.0CD40LG, CTLA4, IFNG, IL10, IL4, TNF
39
Show member pathways
7.9CD40LG, IFNG, IL10, IL4, MYD88, TNF

GO Terms for genes affiliated with Paracoccidioidomycosis

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Biological processes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:003280010.6IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:000274010.6IL10, TNF
3positive regulation of mononuclear cell migrationGO:007167710.5IL4, TNF
4type 2 immune responseGO:004209210.5IL10, IL4
5regulation of immunoglobulin secretionGO:005102310.5CD40LG, TNF
6negative regulation of interleukin-6 productionGO:003271510.4IL10, TNF
7positive regulation of calcidiol 1-monooxygenase activityGO:006055910.4IFNG, TNF
8negative regulation of endothelial cell apoptotic processGO:200035210.4IL10, IL4
9positive regulation of membrane protein ectodomain proteolysisGO:005104410.4IFNG, TNF
10negative regulation of nitric oxide biosynthetic processGO:004501910.4IL10, IL4
11positive regulation of interleukin-10 productionGO:003273310.3CD40LG, IL4
12positive regulation of interleukin-23 productionGO:003274710.3IFNG, MYD88
13regulation of establishment of endothelial barrierGO:190314010.3TNF, TNFRSF1A
14death-inducing signaling complex assemblyGO:007155010.3TNF, TNFRSF1A
15positive regulation of T cell proliferationGO:004210210.3IFNG, IL4
16protein import into nucleus, translocationGO:000006010.2IFNG, TNF
17positive regulation of ceramide biosynthetic processGO:200030410.2TNF, TNFRSF1A
18positive regulation of isotype switching to IgG isotypesGO:004830410.2IFNG, IL4
19B cell differentiationGO:003018310.1CD40LG, IL10, IL4
20positive regulation of osteoclast differentiationGO:004567210.1IFNG, TNF
21defense response to protozoanGO:004283210.1IFNG, IL10, IL4
22positive regulation of sequence-specific DNA binding transcription factor activityGO:005109110.1IL10, IL4, TNF
23establishment of protein localization to plasma membraneGO:009000210.0TNF, TNFRSF1A
24extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.9TNF, TNFRSF1A
25positive regulation of MHC class II biosynthetic processGO:00453489.9IFNG, IL10, IL4
26regulation of immune responseGO:00507769.8CD40LG, IFNG, IL4
27response to virusGO:00096159.8IFNG, MYD88, TNF
28positive regulation of NF-kappaB transcription factor activityGO:00510929.7CD40LG, MYD88, TNF
29positive regulation of chemokine biosynthetic processGO:00450809.7IFNG, IL4, MYD88, TNF
30negative regulation of growth of symbiont in hostGO:00441309.6IFNG, IL10, MYD88, TNF
31cytokine-mediated signaling pathwayGO:00192219.6IFNG, MYD88, TNFRSF1A
32positive regulation of transcription, DNA-templatedGO:00458939.5IFNG, IL10, IL4, TNF
33cell surface receptor signaling pathwayGO:00071669.5IFNG, TNF, TNFRSF1A
34defense response to bacteriumGO:00427429.5IFNG, IL10, TNF
35regulation of cell proliferationGO:00421279.2MYD88, TNF, TNFRSF1A
36immune responseGO:00069559.2IFNG, IL10, IL4, TNF
37inflammatory responseGO:00069549.2IL10, MYD88, TNF, TNFRSF1A
38response to organic substanceGO:00100339.0ALB, IL10, TNF
39negative regulation of apoptotic processGO:00430668.1ALB, CD40LG, GLO1, IL10, IL4, MYD88

Sources for Paracoccidioidomycosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet