PCM
MCID: PRC002
MIFTS: 70

Paracoccidioidomycosis (PCM) malady

Infectious diseases, Immune diseases categories

Summaries for Paracoccidioidomycosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in paracoccidioides brasiliensis.

MalaCards: Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to thyroiditis and malaria. An important gene associated with Paracoccidioidomycosis is CXCL10 (chemokine (C-X-C motif) ligand 10), and among its related pathways are Cell adhesion molecules (CAMs) and Regulation by c-FLIP. The drugs ketoconazole and itraconazole and the compounds cyclosporin a and rantes have been mentioned in the context of this disorder. Affiliated tissues include skin or, bone and lymph nodes, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Wikipedia:63 Paracoccidioidomycosis (also known as \"Brazilian blastomycosis,\" \"South American... more...

Aliases & Classifications for Paracoccidioidomycosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Immune diseases


Characteristics (Orphanet epidemiological data):

48
paracoccidioidomycosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

paracoccidioidomycosis 8 42 44 48 60
mucocutaneous-lymphangitic paracoccidioidomycosis 8
paracoccidioidomycosis, unspecified 8
lutz-splendore-almeida disease 42
south american blastomycosis 42
protein-energy malnutrition 60
paracoccidioidomycosis nos 8
paracoccidioidal granuloma 42
paracoccidioidal mycosis 8
lobo disease 42
pcm 42


External Ids:

Disease Ontology8 DOID:12662
NCIt39 C34891
MeSH34 D010229
ICD9CM27 116.1
ICD10 via Orphanet26 B41.7, B41.8, B41.9 B41.0, more
MESH via Orphanet35 D010229
SNOMED-CT via Orphanet57 59925007
UMLS via Orphanet61 C0030409
ICD1025 B41, B41.9

Related Diseases for Paracoccidioidomycosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 224)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.9FASLG, CTLA4
2malaria30.8GSR, TPI1, IL10, CXCL9, G6PD, HSPD1
3ischemia30.7GSR
4cystic fibrosis30.4TLR4
5leukemia30.4TNFRSF1A, GLO1, FASLG, TLR4
6tuberculosis30.4GSR, TPI1, IL10, CXCL9, CXCL10, MYD88
7dilated cardiomyopathy30.2HSPD1
8meningitis30.2CXCL10
9influenza30.2CD28, CXCL10, MYD88, CXCL9
10deficiency anemia30.2TPI1, GSR, G6PD
11viral hepatitis30.2FASLG, G6PD, TNFRSF1A
12leishmaniasis30.2TNFRSF1A, GLO1, IL10, IL5
13alzheimer's disease30.2GLO1, TPI1, GSR, TNFRSF1A
14tetanus30.2HSPD1, IL10, IL5, CD28
15inflammatory bowel disease30.2HSPD1, TLR4, IL10, TNFRSF1A, CTLA4, CXCL10
16hepatitis30.1GSR, CXCL10, FASLG, TNFRSF1A
17squamous cell carcinoma30.1FASLG, CTLA4, GLO1, CKS1B, TPI1, CXCL9
18cervicitis30.0HSPD1
19gingivitis30.0HSPD1
20esophagitis30.0IL5
21pancreatitis29.8IL10
22vasculitis29.8HSPD1, CTLA4
23colon cancer29.8HSPD1, FASLG
24silicosis29.8FASLG
25sarcoidosis29.8CD28, CXCL10, CXCL9, IL12RB2
26schistosomiasis29.8IL10, GSR, IL5
27periodontitis29.8HSPD1, TLR4, IL10
28pneumonia29.8IL5, IL10, MYD88, CXCL10, TLR4
29hepatitis c29.8IL10, CXCL10, CD28, CTLA4, TLR4, GSR
30prostate cancer29.8FASLG, GSR, TPI1, CXCL10, GLO1, CTLA4
31arthritis29.8CTLA4, TNFRSF1A, TLR4, HSPD1, CXCL10, CXCL9
32lung cancer29.8TLR4, HSPD1, TNFRSF1A, GSR, CTLA4, GLO1
33rheumatoid arthritis29.8CXCL10, FASLG, PDCD1, CXCL9, HSPD1, TLR4
34protein-energy malnutrition11.5
35kwashiorkor10.6
36marasmus10.5
37liver cirrhosis10.5
38peritonitis10.5
39cerebritis10.4
40measles10.4
41blastomycosis10.3
42biotin deficiency10.3
43lactose intolerance10.3
44cerebral malaria10.3
45acute leukemia10.3
46neuroblastoma10.3
47histoplasmosis10.3
48burns10.2
49acute diarrhea10.2
50visceral leishmaniasis10.2

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to paracoccidioidomycosis

Clinical Features for Paracoccidioidomycosis

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Drugs & Therapeutics for Paracoccidioidomycosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Paracoccidioidomycosis

Search NIH Clinical Center for Paracoccidioidomycosis

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Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Paracoccidioidomycosis

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Anatomical Context for Paracoccidioidomycosis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Paracoccidioidomycosis:

32
Bone, Lung, Skin, Lymph node, T cells, Testes, Monocytes, Bone marrow, Prostate, Adrenal gland, Myeloid, B cells, Colon, Spinal cord, Thymus, Spleen

FMA organs/tissues related to Paracoccidioidomycosis:

14
Skin or, Bone, Lymph nodes, Mucosa

Animal Models for Paracoccidioidomycosis or affiliated genes

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36MGI
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Publications for Paracoccidioidomycosis

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50PubMed
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Articles related to Paracoccidioidomycosis:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Hepatic involvement in paediatric patients with paracoccidioidomycosis: a histological study. (24117867)
2014
2
Disseminated paracoccidioidomycosis. (23468353)
2013
3
Paracoccidioides brasiliensis and P. lutzii antigens elicit different serum IgG responses in chronic paracoccidioidomycosis. (24005606)
2013
4
In pulmonary paracoccidioidomycosis IL-10 deficiency leads to increased immunity and regressive infection without enhancing tissue pathology. (24205424)
2013
5
Paracoccidioidomycosis case series with and without central nervous system involvement. (23152341)
2012
6
Cutaneous disseminated paracoccidioidomycosis. (22232437)
2012
7
Paracoccidioidomycosis of external genitalia: report of six new cases and review of the literature. (22570027)
2012
8
Single oral paracoccidioidomycosis mimicking other lesions: report of eight cases. (21837507)
2012
9
Application of PCR in serum samples for diagnosis of paracoccidioidomycosis in the southern Bahia-Brazil. (23209853)
2012
10
Seropositive antiaquaporin-4 antibody associated with multisegmental myelitis in a patient with paracoccidioidomycosis. (21803375)
2011
11
Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis. (22046142)
2011
12
Analysis of invariant natural killer T cells in human paracoccidioidomycosis. (21805204)
2011
13
Histoplasmosis and paracoccidioidomycosis in a non-endemic area: a review of cases and diagnosis. (21199139)
2011
14
Experimental chemotherapy in paracoccidioidomycosis using ruthenium NO donor. (21437728)
2011
15
Cutaneous and pulmonary paracoccidioidomycosis in a patient with a malignant visceral tumor. (22281919)
2011
16
Paracoccidioidomycosis: a series of 66 patients with oral lesions from an endemic area. (20406390)
2011
17
Immunology of paracoccidioidomycosis. (21738969)
2011
18
Combined itraconazole-pentoxifylline treatment promptly reduces lung fibrosis induced by chronic pulmonary paracoccidioidomycosis in mice. (20851204)
2011
19
Cell-free antigens from Paracoccidioides brasiliensis drive IL-4 production and increase the severity of paracoccidioidomycosis. (21731741)
2011
20
Is the geographical origin of a Paracoccidioides brasiliensis isolate important for antigen production for regional diagnosis of paracoccidioidomycosis? (19422525)
2010
21
Human T lymphotropic virus 1 and paracoccidioidomycosis: a probable association in Latin America. (20560735)
2010
22
Poly(lactic acid-glycolic acid) nanoparticles markedly improve immunological protection provided by peptide P10 against murine paracoccidioidomycosis. (20136827)
2010
23
Amphotericin B in poly(lactic-co-glycolic acid) (PLGA) and dimercaptosuccinic acid (DMSA) nanoparticles against paracoccidioidomycosis. (19151037)
2009
24
Deficiency of IL-12p40 subunit determines severe paracoccidioidomycosis in mice. (18608917)
2008
25
Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM). (18689616)
2008
26
Paracoccidioidomycosis. (18346557)
2008
27
Characterization of inflammatory cells in oral paracoccidioidomycosis. (17577332)
2007
28
Paracoccidioidomycosis: no genetic damage in human peripheral blood cells of patients assessed by single-cell gel (comet) assay. (17876475)
2007
29
Association between paracoccidioidomycosis and tuberculosis: reality and misdiagnosis. (17906791)
2007
30
Diagnosis of Paracoccidioidomycosis by detection of antigen and antibody in bronchoalveolar lavage fluids. (17035512)
2006
31
Adrenal function in 23 children with paracoccidioidomycosis. (17221130)
2006
32
The IX International Meeting on Paracoccidioidomycosis, Aguas de LindA^ia, SP, Brazil, October 2-5, 2005. Abstracts. (16258683)
2005
33
Fas-Fas ligand (CD95-CD95L) and cytotoxic T lymphocyte antigen-4 engagement mediate T cell unresponsiveness in patients with paracoccidioidomycosis. (12717632)
2003
34
Programmed cell death in thymus during experimental paracoccidioidomycosis. (12687355)
2003
35
Ocular and central nervous system paracoccidioidomycosis in a pregnant woman with acquired immunodeficiency syndrome. (12208267)
2002
36
The oral route in the pathogenesis of paracoccidioidomycosis: an experimental study in BALB/c mice infected with P. brasiliensis conidia. (11554579)
2001
37
Experimental paracoccidioidomycosis in high and low antibody responder mice of Selection IV-A. (10975699)
2000
38
Cutaneous primary paracoccidioidomycosis. (10972096)
2000
39
Differential antibody isotype expression to the major Paracoccidioides brasiliensis antigen in juvenile and adult form paracoccidioidomycosis. (10602660)
1999
40
Hypercalcaemia and paracoccidioidomycosis. (9764330)
1998
41
Paracoccidioidomycosis in women. (17655417)
1998
42
Paracoccidioidomycosis in a boy infected with HIV. (9470418)
1997
43
IgG, IgM and IgA antibody response for the diagnosis and follow-up of paracoccidioidomycosis: comparison of counterimmunoelectrophoresis and complement fixation. (9229338)
1997
44
Paracoccidioidomycosis of bones and joints. A clinical, radiologic, and pathologic study of 9 cases. (8699961)
1996
45
Experimental paracoccidioidomycosis in hamster: transmission electron microscopy of inoculation site lesion. (7855485)
1994
46
Recovery of adrenal function after treatment of paracoccidioidomycosis. (8390794)
1993
47
Agarose gel immunodiffusion tests with the addition of PEG (polyethylene glycol 6000) for the diagnosis and serological follow up of paracoccidioidomycosis infection. (8302361)
1993
48
Experimental murine paracoccidioidomycosis: relationship among the dissemination of the infection, humoral and cellular immune responses. (8403521)
1993
49
Pulmonary paracoccidioidomycosis in immunized mice. (1406901)
1992
50
Chronic pulmonary paracoccidioidomycosis masquerading as lymphangitis carcinomatosa. (3704971)
1986

Genetic Variations for Paracoccidioidomycosis

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Expression for genes affiliated with Paracoccidioidomycosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for genes affiliated with Paracoccidioidomycosis

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Sources:
29KEGG, 53Reactome, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2PDCD1, ICOS
2
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10.2TNFRSF1A, FASLG
3
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10.0IL10, FASLG, TNFRSF1A
410.0TLR4, MYD88, CXCL10
510.0FASLG, MYD88, IL10
610.0IL10, MYD88, TLR4
710.0IL10, MYD88, TLR4
8
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10.0IL5, CTLA4, FASLG
910.0MYD88, TNFRSF1A, TLR4
1010.0MYD88, TNFRSF1A, TLR4
1110.0HSPD1, TLR4, MYD88
1210.0HSPD1, FASLG, IL5
1310.0IL5, CD28, TNFRSF1A
1410.0CD28, CTLA4, TLR4
15
Immune response Bacterial infections in normal airways
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9.9MYD88, FASLG, TLR4
16
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9.9ICOS, PDCD1, CTLA4, CD28
17
Hide members
9.8CD28, CXCL10, IL12RB2, IL5
18
Hide members
9.8TLR4, TNFRSF1A, FASLG, MYD88
199.8TLR4, TNFRSF1A, MYD88, CD28
20
Hide members
9.8IL10, IL12RB2, CD28, TLR4
219.8HSPD1, TLR4, TNFRSF1A, MYD88, IL10
22
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9.7ICOS, PDCD1, CTLA4, CD28, IL5
23
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9.6TLR4, TNFRSF1A, MYD88, IL12RB2, IL10, IL5
24
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9.5TLR4, TNFRSF1A, FASLG, MYD88, CD28, CXCL10
25
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9.4TLR4, TNFRSF1A, FASLG, MYD88, CXCL10, CXCL9
26
Hide members
9.4TNFRSF1A, CD28, CXCL10, CXCL9, IL12RB2, IL10
27
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9.3TLR4, ICOS, PDCD1, CTLA4, MYD88, CD28
28
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9.1IL5, HSPD1, ICOS, TNFRSF1A, FASLG, CTLA4
29
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9.1TLR4, TNFRSF1A, FASLG, CD28, CXCL10, CXCL9
30
Hide members
9.0TLR4, TNFRSF1A, MYD88, CD28, CXCL10, CXCL9

Compounds for genes affiliated with Paracoccidioidomycosis

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1cyclosporin a44 28 5912.6CTLA4, CD28
2rantes4410.4TLR4, TNFRSF1A, FASLG
3glucose4410.4GLO1, FASLG, TPI1
4indomethacin44 59 28 1113.4GLO1, IL5, HSPD1
5infliximab44 49 1112.3IL10, TLR4, TNFRSF1A, CXCL10
6endotoxin4410.3TNFRSF1A, HSPD1, FASLG, MYD88
7cycloheximide4410.3HSPD1, CXCL10, FASLG
8aspartate4410.3FASLG, G6PD, HSPD1, TPI1
9glutamate4410.3TPI1, GLO1, TNFRSF1A, HSPD1
10con a4410.2IL5, IL10, CTLA4, CD28
11polyinosinic-polycytidylic acid4410.2IL5, IL10, CXCL10, TLR4
12imiquimod44 28 59 1113.2FASLG, IL10, IL5, TLR4
13oxygen44 2411.2CD28, TNFRSF1A, MYD88
14thalidomide44 49 59 1113.1TNFRSF1A, FASLG, CTLA4, IL5, IL10
15manganese superoxide4410.1GSR, TPI1, FASLG, TNFRSF1A, HSPD1
16tarc4410.1IL10, IL5, CXCL10, CXCL9
17glatiramer acetate44 1111.1CTLA4, IL10, IL5
18ifn-alpha4410.1FASLG, TLR4, CXCL10, CXCL9, IL10
19dexamethasone44 49 28 1113.1CXCL9, CTLA4, FASLG, TLR4, IL5
20h2o24410.1G6PD, FASLG, TNFRSF1A, HSPD1
21allergens4410.0TLR4, PDCD1, CTLA4, CXCL10, IL10, IL5
22ivig4410.0IL10, TNFRSF1A, IL5, FASLG
23il 104410.0CXCL9, IL10, IL5, TLR4, CXCL10, CTLA4
24chloroquine44 2 49 28 1114.0G6PD, TNFRSF1A, CXCL10, IL10, GSR, TLR4
25tgf beta14410.0IL10, TNFRSF1A, FASLG, CTLA4, TLR4
26ccl344 2811.0CXCL10, TLR4, CXCL9, IL10
27methylglyoxal44 2810.9GLO1, GSR, TPI1
28glyceraldehyde 3-phosphate449.9G6PD, HSPD1, TLR4, GLO1, TPI1, GSR
29methotrexate44 49 1111.9FASLG, TNFRSF1A, CTLA4, GLO1, IL5, GSR
30cyclophosphamide44 49 1111.9FASLG, G6PD, IL10, GSR, CXCL9
31n acetylcysteine449.8G6PD, FASLG, TNFRSF1A, GSR, HSPD1, TLR4
32tacrolimus44 49 1111.8CTLA4, CD28, CXCL10, IL10, IL5, FASLG
33ionomycin449.8IL10, IL5, CXCL9, CD28, CTLA4, FASLG
34superoxide44 2410.8TPI1, HSPD1, GSR, GLO1, G6PD, TNFRSF1A
35doxorubicin44 49 1111.8TNFRSF1A, HSPD1, GSR, GLO1, G6PD, FASLG
36ly294002449.7CTLA4, IL5, IL10, FASLG, TLR4, MYD88
37lactate449.7G6PD, GLO1, TPI1, HSPD1, FASLG, GSR
38creatinine449.7GLO1, HSPD1, TNFRSF1A, GSR, G6PD, TPI1
39adenylate449.7CXCL10, GLO1, IL5, FASLG, G6PD, TPI1
40alanine449.6FASLG, TNFRSF1A, TLR4, HSPD1, CXCL10, GLO1
41vegf449.6CXCL9, HSPD1, TNFRSF1A, FASLG, CXCL10, IL10
42guanidine hydrochloride449.6GSR, TPI1, G6PD, HSPD1
43nitric oxide44 11 2411.6TLR4, FASLG, MYD88, IL10, CXCL9, GLO1
44cholesterol44 28 11 2412.6CXCL10, HSPD1, TNFRSF1A, FASLG, TLR4, CTLA4
45atp44 2810.5MYD88, TLR4, HSPD1, TNFRSF1A, CXCL9, CXCL10
46phosphatidylinositol449.5HSPD1, TLR4, CD28, TNFRSF1A, FASLG, CXCL9
47genistein44 28 59 2 11 2414.4CXCL10, CD28, TLR4, FASLG, IL5, GSR
48cysteine449.3TNFRSF1A, GSR, IL5, CD28, GLO1, CTLA4
49lipid449.2GLO1, CXCL10, TPI1, GSR, CD28, MYD88
50tyrosine448.7TPI1, IL12RB2, CKS1B, HSPD1, CXCL9, PDCD1

GO Terms for genes affiliated with Paracoccidioidomycosis

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16Gene Ontology
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Cellular components related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor complexGO:04669610.2TLR4, HSPD1
2extracellular spaceGO:0056159.3HSPD1, TNFRSF1A, FASLG, CXCL10, CXCL9, IL10
3integral to plasma membraneGO:0058879.1TLR4, ICOS, TNFRSF1A, FASLG, CTLA4, CD28
4external side of plasma membraneGO:0098979.0IL12RB2, TLR4, ICOS, PDCD1, FASLG, CTLA4

Biological processes related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.3IL10, TLR4
2negative regulation of interleukin-6 productionGO:03271510.3TLR4, TNFRSF1A, IL10
3positive regulation of interferon-gamma productionGO:03272910.3IL12RB2, TLR4, HSPD1
4interferon-gamma productionGO:03260910.3TLR4, IL12RB2
5positive regulation of interleukin-6 productionGO:03275510.3HSPD1, TLR4, MYD88
6negative regulation of B cell proliferationGO:03088910.2IL10, CTLA4
7glutathione metabolic processGO:00674910.2G6PD, GLO1, GSR
8cellular response to mechanical stimulusGO:07126010.2MYD88, TNFRSF1A, TLR4
9T cell costimulationGO:03129510.2CD28, CTLA4, PDCD1, ICOS
10positive regulation of interferon-alpha productionGO:03272710.2HSPD1, TLR4
11pentose-phosphate shuntGO:00609810.1G6PD, TPI1
12cell surface receptor signaling pathwayGO:00716610.1MYD88, CD28, CXCL10, IL12RB2
13MyD88-dependent toll-like receptor signaling pathwayGO:00275510.1HSPD1, TLR4, MYD88
14positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.1MYD88, FASLG, TNFRSF1A, TLR4
15response to lipopolysaccharideGO:03249610.0TLR4, TNFRSF1A, FASLG, CXCL10, IL12RB2
16cell-cell signalingGO:00726710.0IL10, CXCL9, CXCL10, FASLG
17B cell proliferationGO:0421009.9IL10, HSPD1
18inflammatory responseGO:0069549.9TNFRSF1A, MYD88, CXCL10, CXCL9, IL10, IL5
19immune responseGO:0069559.7IL5, CXCL9, CXCL10, CTLA4, FASLG, ICOS

Molecular functions related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.8IL5, IL10, CXCL9, FASLG
2protein bindingGO:0055157.8TPI1, HSPD1, CKS1B, EXOSC3, TLR4, PDCD1

Products for genes affiliated with Paracoccidioidomycosis

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Sources for Paracoccidioidomycosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet