Paracoccidioidomycosis malady

Disease Ontology: A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in paracoccidioides brasiliensis.⁶

MalaCards: Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis (disorder), is related to papillary thyroid carcinoma and cholangiocarcinoma. An important gene associated with Paracoccidioidomycosis is CXCL9 (chemokine (C-X-C motif) ligand 9), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Graft-versus-host disease. The drugs amphotericin b and itraconazole and the compounds ionomycin and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include mucosa, lymph nodes and bone, and related mouse phenotypes are renal/urinary system and skeleton.

Wikipedia: Paracoccidioidomycosis (also known as \"Brazilian blastomycosis,\" \"South American...⁴⁴ more...

Aliases & Descriptions:

paracoccidioidomycosis 6 30 8 32 43 mucocutaneous-lymphangitic paracoccidioidomycosis (disorder) 6 mucocutaneous-lymphangitic paracoccidioidomycosis 6 paracoccidioidomycosis, unspecified (disorder) 6 paracoccidioidomycosis nos (disorder) 6 paracoccidioidomycosis (disorder) 6

lutz-splendore-almeida disease 30 south american blastomycosis 30 paracoccidioidal granuloma 30 paracoccidioidal mycosis 6 lobo disease 30 pcm 30

Diseases related to paracoccidioidomycosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 711)

id	Related Disease	Score	Top Affiliating Genes
1	papillary thyroid carcinoma	27.5	FASLG, FAS, IFNG, HLA-DQB1, HLA-DRB1, TNF
2	cholangiocarcinoma	26.9	BMP6, CKS1B, FASLG, FAS, ALB, TNF
3	chronic myeloid leukemia	26.5	PDCD1, BMP6, IL10, IL4, FASLG, FAS
4	thyroid carcinoma	26.5	BMP6, CKS1B, FASLG, FAS, IFNG, HLA-DQB1
5	hypercalcemia	26.2	BMP6, IFNG, ALB, TNF, CRP, POMC
6	pulmonary tuberculosis	26.0	IL10, IL4, IFNG, GLO1, HLA-DQB1, HLA-DRB1
7	tuberculosis	25.3	IL10, IL4, IFNG, TNF, NOS2, TLR4
8	acute leukemia	24.5	BMP6, GSR, IL4, FASLG, FAS, IFNG
9	eosinophilia	24.4	CD4, IL10, IL4, IL5, FAS, IFNG
10	myeloid leukemia	23.9	PDCD1, BMP6, CD4, IL10, IL4, IL5
11	ovarian carcinoma	22.8	BMP6, CD28, IL10, IL4, FASLG, FAS
12	schizophrenia	22.6	BMP6, GSR, IL10, IL4, IL5, FAS
13	acute myeloid leukemia	22.2	BMP6, IL4, IL5, FASLG, FAS, IFNG
14	thyroiditis	20.7	BMP6, CKS1B, CD28, CD4, GSR, IL10
15	ovarian cancer	20.2	PDCD1, MYD88, BMP6, CD4, GSR, IL10
16	leukemia	19.6	PDCD1, MYD88, BMP6, CD28, CD4, GSR
17	carcinoma	19.3	PDCD1, MYD88, BMP6, CKS1B, CD28, CD4
18	neuronitis	19.3	MYD88, BMP6, CD4, GSR, IL10, IL4
19	breast cancer	16.7	PDCD1, BMP6, CKS1B, CD4, GSR, IL10
20	viral encephalitis	13.6	IL10, CXCL10, CXCL9
21	chronic eosinophilic pneumonia	13.6	IL10, IL5, CXCL9
22	allergic contact dermatitis of eyelid	13.5	IL5, CXCL10, CXCL9
23	lumbar disc degeneration	13.5	IL10, FASLG, FAS
24	systemic lupus erythematosus	13.4	PDCD1, FASLG, CTLA4
25	sydenham's chorea	13.4	CRP, CXCL10, CXCL9
26	htlv-1 associated myelopathy	13.4	PDCD1, FASLG, FAS
27	cutaneous leishmaniasis	13.3	IL10, IFNG
28	punctate inner choroidopathy	13.3	IL10, TNF
29	colorectal cancer	13.3	TLR2, TLR4
30	buruli ulcer disease	13.3	IL10, IFNG
31	tuberculoid leprosy	13.3	IL10, IFNG
32	cystoid macular edema	13.2	IL10, IFNG, CXCL10
33	immunodysregulation	13.2	BMP6, IL10, HLA-DRB1
34	multiple sclerosis	13.2	HLA-DQB1, HLA-DRB1
35	intestinal volvulus	13.2	GSR, IL5, HSPD1, TLR2
36	post-transplant lymphoproliferative disease	13.2	IL10, TNF, TNFRSF1A
37	tubulointerstitial nephritis and uveitis	13.2	HLA-DQB1, HLA-DRB1
38	senile cataract	13.2	GSR, ALB, G6PD
39	congenital hemolytic anemia	13.2	IFNG, TPI1, G6PD
40	chronic inflammatory demyelinating polyneuropathy	13.2	CD28, TNF, CTLA4, CXCL9
41	whipple disease	13.2	HSPD1, HLA-DQB1, HLA-DRB1
42	eosinophilic fasciitis	13.2	IL10, IL5, IFNG
43	peritoneal carcinoma	13.2	IL10, IFNG, CXCL10
44	periodic fever, familial, autosomal dominant	13.2	TNF, TNFRSF1A
45	nodular goiter	13.2	GSR, IFNG, CXCL10
46	lymphadenitis	13.2	PDCD1, FASLG, CRP, CXCL9
47	familial mediterranean fever	13.2	TNF, TNFRSF1A
48	orthostatic hypotension	13.1	ALB, G6PD, POMC
49	icos deficiency	13.1	IFNG, ICOS
50	autoimmune lymphoproliferative syndrome	13.1	CD4, IL10, FASLG, FAS

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 amphotericin b, amphotericin b cholesteryl sulfate, amphotericin b lipid complex, amphotericin b liposome, itraconazole, ketoconazole

MalaCards organs/tissues related to paracoccidioidomycosis:

²²

FMA organs/tissues related to paracoccidioidomycosis:

¹¹

MGI Mouse Phenotypes related to paracoccidioidomycosis:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.3	PDCD1, MYD88
2	skeleton phenotype	MP:0005390	9.7	CTLA4, TNFRSF1A, FAS, BMP6, MYD88
3	endocrine/exocrine gland phenotype	MP:0005379	9.3	TLR2, CTLA4, IFNG, FASLG
4	hematopoietic system phenotype	MP:0005397	9.3	PDCD1, MYD88, CKS1B, CD28, IL12RB2, IL5
5	growth/size phenotype	MP:0005378	9.2	TLR4, HSPD1, FAS, IL5, CKS1B, BMP6
6	liver/biliary system phenotype	MP:0005370	9.1	TLR4, TLR2, CTLA4, IFNG, IL12RB2
7	digestive/alimentary phenotype	MP:0005381	8.3	TLR2, NOS2, CTLA4, ICOS, IFNG, CD4
8	adipose tissue phenotype	MP:0005375	8.2	POMC, TLR4, TLR2, NOS2, TNFRSF1A, TNF
9	muscle phenotype	MP:0005369	8.1	TLR2, NOS2, TNFRSF1A, TNF, HLA-DQB1, IL10
10	nervous system phenotype	MP:0003631	7.7	G6PD, TLR2, TLR4, CXCL10, POMC, TNFRSF1A
11	immune system phenotype	MP:0005387	7.5	MYD88, POMC, CXCL10, CKS1B, CD4, IFNG
12	reproductive system phenotype	MP:0005389	7.5	TLR4, NOS2, TNFRSF1A, TNF, HSPD1, IFNG
13	integument phenotype	MP:0010771	7.3	POMC, TLR4, TLR2, CTLA4, TNFRSF1A, IFNG
14	normal phenotype	MP:0002873	6.8	TLR2, CTLA4, TPI1, HLA-DQB1, ALB, IFNG
15	vision/eye phenotype	MP:0005391	6.8	IFNG, TNF, TNFRSF1A, NOS2, TLR4, FAS
16	tumorigenesis	MP:0002006	6.6	POMC, TLR4, TLR2, NOS2, TNFRSF1A, TNF
17	behavior/neurological phenotype	MP:0005386	6.5	TLR4, TLR2, NOS2, TNFRSF1A, TNF, HLA-DQB1
18	mortality/aging	MP:0010768	6.5	CTLA4, NOS2, G6PD, TLR2, TLR4, CXCL9
19	homeostasis/metabolism phenotype	MP:0005376	5.6	TNFRSF1A, CTLA4, CRP, NOS2, G6PD, TLR2
20	cardiovascular system phenotype	MP:0005385	5.2	CTLA4, CRP, NOS2, G6PD, TLR2, TLR4
21	cellular phenotype	MP:0005384	4.7	HLA-DQB1, TNF, TNFRSF1A, CTLA4, NOS2, G6PD

Articles related to paracoccidioidomycosis:

(show all 25)

id	Title	Authors	Year	Affiliating Genes
1	Interferon-gamma and interleukin-4 single nucleotide gene polymorphisms in Paracoccidioidomycosis. (19682920)	Bozzi A.... Goes A.M.	2009	IL4, IFNG
2	Altered expression of the costimulatory molecules CD80, CD86, CD152, PD-1 and ICOS on T-cells from paracoccidioidomycosis patients: lack of correlation with T-cell hyporesponsiveness. (18757242)	Cacere C.R.... Benard G.	2008	CTLA4, CD28, PDCD1
3	Toll-like receptors and fungal infections: the role of TLR2, TLR4 and MyD88 in paracoccidioidomycosis. (18384366)	Calich V.L.... Loures F.V.	2008	TLR2, TLR4, MYD88
4	Kinetics of IFN-gamma, TNF-alpha, IL-10 and IL-4 production by mononuclear cells stimulated with gp43 peptides, in patients cured of paracoccidioidomycosis. (17568881)	Sadahiro A.... Shikanai-Yasuda M.A.	2007	IL10
5	Generic human leukocyte antigen class II (DRB1 and DQB1) alleles in patients with paracoccidioidomycosis. (17325942)	Sadahiro A.... Shikanai-Yasuda M.A.	2007	HLA-DQB1, HLA-DRB1
6	Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis. (17302897)	Corvino C.L.... Blotta M.H.	2007	TNFRSF1A, CXCL10, CXCL9
7	Flow-cytometric analysis of cytokine production in human paracoccidioidomycosis. (17045486)	Mamoni R.L.... Blotta M.H.	2006	TNF, IL10, CXCL9
8	Cytokeratin expression in pseudoepitheliomatous hyperplasia of oral paracoccidioidomycosis. (16882606)	Kaminagakura E.... Scully C.	2006	CKS1B
9	Cytokines released from blood monocytes and expressed in mucocutaneous lesions of patients with paracoccidioidomycosis evaluated before and during trimethoprim-sulfamethoxazole treatment. (16536806)	Parise-Fortes M.R.... Peracoli M.T.	2006	TNF, IL10
10	Interleukin-10 and tumor necrosis factor-alpha single nucleotide gene polymorphism frequency in paracoccidioidomycosis. (17145373)	Bozzi A.... Goes A.M.	2006	TNF, IL10
11	Hypercalcemia and multiple osteolytic lesions in a child with disseminated paracoccidioidomycosis and pulmonary tuberculosis (16106322)	Tresoldi A.T.... Belangero V.M.	2005	ALB
12	The role of interleukin-10 in the differential expression of interleukin-12p70 and its beta2 receptor on patients with active or treated paracoccidioidomycosis and healthy infected subjects. (15596413)	Romano C.C.... Benard G.	2005	IL10, IL12RB2
13	Paracoccidioidomycosis in children: clinical presenta tion, follow-up and outcome. (15286812)	Pereira R.M.... Tresoldi A.T.	2004	ALB
14	Modulation of CD28 and CD86 expression in patients with paracoccidioidomycosis in different periods of treatment. (15541043)	Bozzi A.... Goes A.M.	2004	CD28
15	Dendritic cells and pattern of cytokines in paracoccidioidomycosis skin lesions. (12652191)	Pagliari C.... Sotto M.N.	2003	TNF, IFNG, IL10
16	Study of bronchoalveolar lavage fluid in paracoccidioidomycosis: cytopathology and alveolar macrophage function in response to gamma interferon; comparison with blood monocytes. (14670450)	Calvi S.A.... Mendes R.P.	2003	IFNG
17	Immunocytochemical localization of cytokines and inducible nitric oxide synthase (iNOS) in oral mucosa and lymph nodes of patients with paracoccidioidomycosis. (12824008)	Neworal E.P.... Blotta M.H.	2003	NOS2, IL10, BMP6
18	Fas-Fas ligand (CD95-CD95L) and cytotoxic T lymphocyte antigen-4 engagement mediate T cell unresponsiveness in patients with paracoccidioidomycosis. (12717632)	Campanelli A.P.... Silva J.S.	2003	FAS, FASLG, CTLA4
19	Imbalance of IL-2, IFN-gamma and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis. (11237434)	Benard G.... Duarte A.J.	2001	IL10
20	High serum interleukin-10 and tumor necrosis factor alpha levels in chronic paracoccidioidomycosis. (11527826)	Fornari M.C.... Diez R.A.	2001	IL10
21	Differential correlation between interleukin patterns in disseminated and chronic human paracoccidioidomycosis. (7648715)	Silva C.L.... Foss N.T.	1995	CRP
22	The association between glyoxalase I and paracoccidioidomycosis infection (8146387)	Balarin M.A.... Freire-Maia D.V.	1993	GLO1
23	Bone marrow involvement and eosinophilia in paracoccidioidomycosis (1340036)	Shikanai-Yasuda M.A.... Amato Neto V.	1992	IL5
24	Adrenocortical dysfunction in paracoccidioidomycosis: comparison between plasma beta-lipotrophin/adrenocorticotrophin levels and adrenocortical tests. (1330381)	Moreira A.C.... Elias L.L.	1992	POMC
25	Isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels, glucose-6-phosphate dehydrogenase and glutathione reductase activities. (1841426)	Barraviera B.... Meira D.A.	1991	GSR, G6PD

Genes related to paracoccidioidomycosis according to GeneCards:

(show all 33)

id	Symbol	Description	Score	GeneCards Section Context
1	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
2	TPI1	triosephosphate isomerase 1	11.0
3	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
4	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
5	CD28	CD28 molecule	11.0	Publications
6	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0
7	IL10	interleukin 10	11.0	Publications
8	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
9	CKS1B	CDC28 protein kinase regulatory subunit 1B	11.0	Publications
10	EXOSC3	exosome component 3	11.0
11	GLO1	glyoxalase I	11.0	Publications
12	ICOS	inducible T-cell co-stimulator	11.0	Publications
13	IL12RB2	interleukin 12 receptor, beta 2	11.0	Publications
14	MYD88	myeloid differentiation primary response gene (88)	11.0	Publications
15	PDCD1	programmed cell death 1	11.0	Publications
16	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications
17	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
18	GSR	glutathione reductase	11.0	Publications
19	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
20	BMP6	bone morphogenetic protein 6	11.0	Publications
21	TLR2	toll-like receptor 2	11.0	Publications
22	TLR4	toll-like receptor 4	11.0	Publications
23	POMC	proopiomelanocortin	11.0	Publications
24	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
25	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
26	IL4	interleukin 4	11.0	Publications
27	TNF	tumor necrosis factor	11.0	Publications
28	ALB	albumin	11.0	Publications
29	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
30	CRP	C-reactive protein, pentraxin-related	11.0	Publications
31	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
32	IFNG	interferon, gamma	11.0	Publications
33	CD4	CD4 molecule	11.0

Pathways related to paracoccidioidomycosis according to GeneDecks:

(show top 50)    (show all 99)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.6	CXCL9
2	Graft-versus-host disease20	10.5	FASLG, CD28
3	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.5	FASLG, TNFRSF1A
4	Bacterial infections in CF airways41	10.5	TLR2, MYD88
5	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.4	CXCL10, MYD88
6	Cell adhesion molecules (CAMs)20	9.8	CTLA4, CD4, ICOS, CD28
7	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.7	IL10, FASLG, FAS, TNFRSF1A, TNF
8	Transcription NF-kB signaling pathway10	9.5	MYD88, CD28, TLR4, TNF, TNFRSF1A
9	Molecular Mechanisms of Cancer36	9.5	CXCL9, IL12RB2, BMP6, CD4, IL5
10	Amoebiasis20	9.5	TLR2, NOS2, TLR4
11	Immune response_TLR signaling pathways41	9.4	CXCL10, TLR4, TLR2, IL4, MYD88
12	Toll-like receptor signaling pathway20	9.4	CXCL9, CXCL10, TLR4, TLR2, TNF, MYD88
13	Transcription_NF-kB signaling pathway41	9.4	TLR4, TNFRSF1A, TNF, MYD88, CD28
14	Selected targets of GCR-alpha10	9.3	FASLG, IL5, TLR2, IL4, HSPD1
15	Immune response_Bacterial infections in normal airways41	9.3	MYD88, IFNG, NOS2
16	all-trans-Retinoic Acid Signaling in Brain36	9.2	IL10, CXCL9, CXCL10, TNF, IL5, IL4
17	PEDF Induced Signaling36	9.2	IL10, BMP6, CXCL9, IL4, IL5, TNF
18	NF-kappaB Signaling3	9.2	TLR2, MYD88, FAS, TNF, TLR4, TNFRSF1A
19	IL-6 Pathway36	9.1	CXCL10, IL5, BMP6, IL10, CXCL9, TNF
20	Intestinal immune network for IgA production20	9.1	CD28, IL10, IL4, HLA-DQB1, HLA-DRB1, ICOS
21	MIF Mediated Glucocorticoid Regulation36	9.0	BMP6, IL5, TNF, TLR4, IL4, IL10
22	MIF Regulation of Innate Immune Cells36	9.0	CXCL10, CXCL9, BMP6, IL10, IL4, TLR4
23	Asthma20	9.0	IL5, IL4, HLA-DQB1, HLA-DRB1, TNF, IL10
24	Akt Signaling36	8.9	TNFRSF1A, CXCL10, IL4, TNF, CD4, CXCL9
25	PGC1Alpha Pathway36	8.9	IL5, IL4, BMP6, TNFRSF1A, CD4
26	Cytokine Network36	8.9	IL5, IL10, IFNG, IL4, TNF
27	African trypanosomiasis20	8.8	MYD88, IL10, FAS, IFNG, FASLG, TNF
28	Malaria20	8.8	TLR2, IFNG, IL10, MYD88, TNF, TLR4
29	Autoimmune thyroid disease20	8.7	HLA-DQB1, CTLA4, HLA-DRB1, FAS, FASLG, IL5
30	Immune response IL-22 signaling pathway10	8.6	CD4, HLA-DRB1, HLA-DQB1, IL12RB2, CD28
31	Immune response MIF in innate immunity response10	8.5	TNF, IFNG, MYD88, NOS2, TLR4
32	Immune response_MIF in innate immunity response41	8.5	NOS2, IFNG, MYD88, TLR4, TNF
33	Tec Kinases Signaling36	8.4	IL5, TLR2, BMP6, IL4, TLR4, IL12RB2
34	MAPK Family Pathway36	8.4	IL4, TNF, IL5, BMP6, CD4, TNFRSF1A
35	STAT3 Pathway36	8.3	CXCL10, TNFRSF1A, TNF, IL5, CXCL9, IL4
36	Measles20	8.3	CD28, IL4, FASLG, FAS, TLR4, IFNG
37	Antioxidant Action of Vitamin-C36	8.3	BMP6, CD28, CD4, IL10, IL12RB2, IL4
38	p38 Signaling36	8.3	TNF, IL5, CXCL10, IL4, IL12RB2, IL10
39	Th1 Differentiation37	8.2	CD28, IFNG, TLR4, CD4, IL12RB2, TNF
40	Type I diabetes mellitus20	8.2	TNF, HLA-DRB1, IFNG, HLA-DQB1, HSPD1, FAS
41	Rheumatoid arthritis20	8.1	CD28, TNF, IFNG, TLR4, TLR2, CTLA4
42	THC Differentiation Pathway36	8.0	HLA-DRB1, TNF, TNFRSF1A, HLA-DQB1, IFNG, IL4
43	Cytokine-cytokine receptor interaction20	7.9	IL5, FASLG, FAS, IL4, IFNG, TNF
44	T cell receptor signaling pathway20	7.9	ICOS, PDCD1, IL5, TNF, CTLA4, IL4
45	Influenza A20	7.7	HLA-DQB1, CXCL10, HLA-DRB1, TNFRSF1A, FASLG, FAS
46	Allograft rejection20	7.6	IL5, FASLG, FAS, IFNG, HLA-DQB1, HLA-DRB1
47	Chagas disease (American trypanosomiasis)20	7.6	MYD88, IL10, FASLG, FAS, IFNG, TNF
48	Toxoplasmosis20	7.3	MYD88, IL10, IFNG, TLR4, TLR2, NOS2
49	Tuberculosis20	7.2	IFNG, HSPD1, TLR4, HLA-DQB1, HLA-DRB1, IL10
50	Leishmaniasis20	7.1	TLR4, TLR2, NOS2, TNF, HLA-DQB1, IFNG

Compounds related to paracoccidioidomycosis according to GeneDecks:

(show top 50)    (show all 218)

id	Compound	Score	Top Affiliating Genes
1	ionomycin32	10.6	IL5, TNFRSF1A
2	n acetylcysteine32	10.4	HSPD1, TLR4
3	ivig32	10.2	CRP, FASLG
4	vegf32	9.8	POMC, CRP, TNFRSF1A, HSPD1
5	h2o232	9.7	IL5, HSPD1, TNFRSF1A, TLR4, POMC
6	calcitriol32 42 9 18 9	13.6	ALB, BMP6, TLR2
7	endotoxin32	9.5	MYD88, FASLG, HSPD1, TNFRSF1A, CXCL9, CXCL10
8	aspartate32	9.5	POMC, BMP6, GSR, FASLG, HSPD1, HLA-DQB1
9	okt332	9.1	FAS, BMP6, TNF, TNFRSF1A, CRP, IL10
10	pge232	9.1	CXCL10, TLR4, CD4, GSR, IL5, FASLG
11	sb 20358032 42	9.9	TNF, IFNG, BMP6, CRP
12	interferon gamma32	8.7	BMP6, IFNG, IL4, IL10, TNF
13	glatiramer acetate32 9 9	10.7	CTLA4, HLA-DRB1, IFNG, IL5, IL10, IL4
14	cyclosporin a32 42	9.7	CD28, IL10, POMC, TLR4, TLR2, CTLA4
15	ifn-alpha32	8.6	CXCL9, CXCL10, TLR4, IFNG, FAS, FASLG
16	imiquimod32 42 9 9	11.6	FASLG, TLR4, TNF, IFNG, IL5, BMP6
17	ccl332	8.5	TLR2, TLR4, CXCL9, TNF, IFNG, IL10
18	thalidomide32 42 9 9	11.5	CTLA4, TNFRSF1A, TNF, IFNG, FASLG, IL5
19	polymyxin b32	8.5	IL10, IL4, IFNG, HSPD1, TNF, TLR2
20	creatinine32	8.4	FAS, HSPD1, TPI1, TNFRSF1A, CRP, G6PD
21	gm-csf32	8.3	TNF, IFNG, BMP6, IL10, IL4, IL5
22	poly(i-c)32	8.3	TLR4, TLR2, TNF, IL4, IFNG, IL5
23	ly29400232	8.3	CTLA4, CRP, NOS2, TLR4, TNF, FASLG
24	chloroquine32 34 9 9	11.3	CD4, BMP6, GSR, IL10, IL4, TNF
25	cysteine32	8.2	IFNG, FASLG, ALB, CD4, GLO1, TNFRSF1A
26	tarc32	8.2	IFNG, IL5, CXCL10, TNF, IL10, CXCL9
27	allergens32	8.2	HLA-DRB1, CXCL10, CTLA4, IFNG, TLR4, IL5
28	polyinosinic-polycytidylic acid32	8.1	IL10, IL4, IL5, IFNG, NOS2, TLR2
29	il 1032	7.9	TLR4, CXCL10, TLR2, CTLA4, TNF, CXCL9
30	hydrocortisone32 9 9	9.8	TNF, CXCL10, BMP6, IL10, IL4, IL5
31	neopterin32	7.8	CD4, IL10, CXCL10, IL4, CRP, IFNG
32	infliximab32 9 9	9.7	CXCL10, TLR4, CRP, CTLA4, TNFRSF1A, TNF
33	methotrexate32 34 42 9 9	11.7	CRP, BMP6, GSR, IL10, IL5, FASLG
34	tacrolimus32 34 9 9	10.6	IFNG, FASLG, IL5, IL4, IL10, CD28
35	lactate32	7.6	TLR4, TPI1, G6PD, CRP, GLO1, FAS
36	simvastatin32 34 42 9 18 9	12.5	IL10, IL4, FASLG, IFNG, TNF, TNFRSF1A
37	prednisolone32 9 9	9.5	CRP, POMC, FAS, IL10, IL5, BMP6
38	histamine32 18	8.5	BMP6, CXCL10, TLR4, TNF, ALB, CXCL9
39	phosphatidylinositol32	7.4	FASLG, HSPD1, TNFRSF1A, FAS, MYD88, BMP6
40	herbimycin a32 42	8.1	TNF, IFNG, NOS2, TNFRSF1A, CD28, IL4
41	actinomycin d32	7.0	IFNG, TPI1, TNF, TNFRSF1A, FASLG, TLR4
42	genistein32 9 18 9	9.8	CD28, IL5, FASLG, FAS, IFNG, TNF
43	nitric oxide32 9 18 9	9.8	FASLG, GLO1, IFNG, TNF, TLR4, TNFRSF1A
44	lipid32	6.7	CD28, MYD88, TNF, TNFRSF1A, GLO1, TPI1
45	alanine32	6.7	ALB, FASLG, CD4, HSPD1, GLO1, HLA-DRB1
46	indomethacin32 9 9	8.4	TNFRSF1A, NOS2, POMC, TNF, GLO1, BMP6
47	rantes32	6.4	CD4, IL10, IL4, IL5, FASLG, FAS
48	tyrosine32	6.1	PDCD1, IL5, CD4, BMP6, CD28, TLR4
49	dexamethasone32 42 34 9 9	10.0	POMC, CXCL9, CXCL10, TLR4, TLR2, NOS2
50	cycloheximide32	5.4	POMC, CXCL10, TLR4, TLR2, NOS2, CRP

Cellular components related to paracoccidioidomycosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	lipopolysaccharide receptor complex	GO:046696	10.1	HSPD1, TLR4
2	membrane raft	GO:045121	8.8	TLR4, TNFRSF1A, TNF, FAS, CD4
3	integral to plasma membrane	GO:005887	8.2	TLR4, TLR2, CTLA4, TNFRSF1A, TNF, HLA-DRB1
4	extracellular region	GO:005576	6.9	POMC, CXCL9, CXCL10, CRP, TNFRSF1A, ALB
5	extracellular space	GO:005615	6.4	TNF, TNFRSF1A, CRP, CXCL10, CXCL9, POMC
6	external side of plasma membrane	GO:009897	6.4	CD28, CXCL9, CXCL10, TLR4, TLR2, CTLA4

Biological processes related to paracoccidioidomycosis according to GeneDecks:

(show top 50)    (show all 63)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of isotype switching	GO:045191	10.3	IL10, IL4
2	inflammatory cell apoptotic process	GO:006925	10.3	FASLG, FAS
3	necrotic cell death	GO:070265	10.1	FASLG, TNF
4	positive regulation of interleukin-10 production	GO:032733	10.1	TLR4, HSPD1, IL4
5	positive regulation of podosome assembly	GO:071803	10.0	IL5, TNF
6	induction of necroptosis by extracellular signals	GO:060555	10.0	TNF, FASLG
7	negative regulation of tumor necrosis factor production	GO:032720	10.0	IL10, TLR4, POMC
8	positive regulation of cytokine secretion	GO:050715	10.0	TLR2, TNF, IL10
9	negative regulation of interleukin-6 production	GO:032715	10.0	TLR4, TNFRSF1A, TNF, IL10
10	MyD88-dependent toll-like receptor signaling pathway	GO:002755	10.0	MYD88, HSPD1, TLR2, TLR4
11	receptor biosynthetic process	GO:032800	10.0	TNF, IL10
12	cellular response to mechanical stimulus	GO:071260	10.0	MYD88, FAS, TNFRSF1A, TLR4
13	positive regulation of chemokine production	GO:032722	10.0	TNF, TLR2, TLR4
14	induction of apoptosis via death domain receptors	GO:008625	9.9	TNF, FAS, FASLG
15	positive regulation of NF-kappaB import into nucleus	GO:042346	9.9	TLR4, TLR2, TNF
16	positive regulation of interferon-gamma production	GO:032729	9.9	TLR4, TNF, HSPD1, IL12RB2
17	negative regulation of interferon-gamma production	GO:032689	9.9	TLR4, HLA-DRB1, IL10
18	response to lipopolysaccharide	GO:032496	9.8	CXCL10, TLR4, TNFRSF1A, FAS, FASLG
19	lipopolysaccharide-mediated signaling pathway	GO:031663	9.8	MYD88, TNF, TLR2, TLR4
20	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.8	TNF, HSPD1, FAS, FASLG
21	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.7	TNF, IL5, IL4, IL10
22	positive regulation of interleukin-6 production	GO:032755	9.7	TLR4, TLR2, TNF, HSPD1, MYD88
23	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.7	TLR4, TNFRSF1A, TNF, FASLG, MYD88
24	positive regulation of vitamin D biosynthetic process	GO:060557	9.6	IFNG, TNF
25	anti-apoptosis	GO:006916	9.5	TNF, GLO1, FAS, IL10, MYD88
26	negative regulation of interleukin-17 production	GO:032700	9.5	IFNG, TLR2, TLR4
27	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.5	IFNG, TNF
28	positive regulation of apoptotic process	GO:043065	9.5	TLR4, CTLA4, TNF, HSPD1, FAS, FASLG
29	defense response to Gram-negative bacterium	GO:050829	9.4	TLR4, NOS2, CD4
30	positive regulation of interleukin-12 production	GO:032735	9.4	TLR4, TLR2, HSPD1, IFNG
31	innate immune response in mucosa	GO:002227	9.4	NOS2, IL4
32	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.4	MYD88, TNF, TLR2, TLR4
33	response to activity	GO:014823	9.4	TLR4, TNF, IL10
34	humoral immune response	GO:006959	9.3	TNF, IFNG, CD28, PDCD1
35	positive regulation of MHC class II biosynthetic process	GO:045348	9.3	IL10, IL4, IFNG, TLR4
36	positive regulation of tumor necrosis factor production	GO:032760	9.2	TLR4, TLR2, TNFRSF1A, IFNG, MYD88
37	positive regulation of chemokine biosynthetic process	GO:045080	9.2	TNF, IFNG, IL4, MYD88
38	positive regulation of nitric oxide biosynthetic process	GO:045429	9.2	TLR4, TLR2, TNF, IFNG
39	negative regulation of growth of symbiont in host	GO:044130	9.1	TLR2, TNF, IFNG, IL10, MYD88
40	positive regulation of killing of cells of other organism	GO:051712	9.1	NOS2, IFNG
41	cellular response to lipopolysaccharide	GO:071222	9.0	TLR4, NOS2, IFNG, IL10
42	T cell costimulation	GO:031295	9.0	CTLA4, HLA-DRB1, HLA-DQB1, ICOS, CD4, CD28
43	cell surface receptor signaling pathway	GO:007166	8.9	CXCL10, IFNG, IL12RB2, CD4, CD28, MYD88
44	defense response to bacterium	GO:042742	8.9	TLR4, NOS2, TNFRSF1A, IFNG, IL10
45	response to hypoxia	GO:001666	8.7	TLR4, NOS2, CRP, TNFRSF1A, TNF, FAS
46	signal transduction	GO:007165	8.6	POMC, CXCL9, CXCL10, TLR2, FAS, FASLG
47	inflammatory response	GO:006954	8.6	CXCL9, CXCL10, TLR2, CRP, TNFRSF1A, TNF
48	cytokine-mediated signaling pathway	GO:019221	8.6	TNFRSF1A, HLA-DRB1, HLA-DQB1, IFNG, IL5, IL12RB2
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.0	POMC, TLR4, TLR2, TNFRSF1A, TNF, IFNG
50	immune response	GO:006955	7.6	BMP6, CXCL9, CXCL10, TLR4, TLR2, CTLA4

Molecular functions related to paracoccidioidomycosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Gram-positive bacterial cell surface binding	GO:051637	9.7	CRP, TLR2
2	lipopolysaccharide receptor activity	GO:001875	9.7	TLR2, TLR4
3	NADP binding	GO:050661	9.3	G6PD, NOS2, GSR
4	cytokine activity	GO:005125	8.1	BMP6, CXCL9, TNF, IFNG, FASLG, IL5
5	protein binding	GO:005515	5.2	EXOSC3, TNF, TNFRSF1A, CTLA4, CRP, NOS2