MCID: PRC002
MIFTS: 56

Paracoccidioidomycosis malady

Rare diseases, Infectious diseases, Immune diseases, Bone diseases, Skin diseases categories

Summaries for Paracoccidioidomycosis

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Disease Ontology:9 A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in paracoccidioides brasiliensis.

MalaCards based summary: Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to hepatitis and vasculitis. An important gene associated with Paracoccidioidomycosis is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Immune response Bacterial infections in normal airways and TNF signaling pathway. The drugs itraconazole and ketoconazole and the compounds glatiramer acetate and p 277 have been mentioned in the context of this disorder. Affiliated tissues include mucosa, lymph nodes and bone, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Wikipedia:63 Paracoccidioidomycosis (also known as \"Brazilian blastomycosis,\" \"South American... more...

Aliases & Classifications for Paracoccidioidomycosis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 43Novoseek, 47Orphanet, 60UMLS, 33MeSH, 55SNOMED-CT, 38NCIt, 27ICD9CM, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Paracoccidioidomycosis, Aliases & Descriptions:

Name: Paracoccidioidomycosis 9 41 43 47 60
Mucocutaneous-Lymphangitic Paracoccidioidomycosis 9
Paracoccidioidomycosis, Unspecified 9
Lutz-Splendore-Almeida Disease 41
South American Blastomycosis 41
Paracoccidioidomycosis Nos 9
 
Paracoccidioidal Granuloma 41
Paracoccidioidal Mycosis 9
Lobo Disease 41
Lobomycosis 60
Pcm 41


Classifications:



Characteristics (Orphanet epidemiological data):

47
paracoccidioidomycosis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology9 DOID:12662
MeSH33 D010229
NCIt38 C34891
ICD9CM27 116.1
Orphanet47 73260
MESH via Orphanet34 D010229
ICD10 via Orphanet26 B41.0, B41.7, B41.8 B41.9, more
UMLS via Orphanet61 C0030409
ICD1025 B41, B41.9

Related Diseases for Paracoccidioidomycosis

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Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.3TNFRSF1A, CXCL10
2vasculitis30.1CTLA4, HSPD1
3periodontitis30.1HSPD1, IL10
4hepatitis c29.8IL10, CXCL10, HSPD1
5tuberculosis29.6TNFRSF1A, HSPD1, TPI1, CXCL10, IL10
6lung cancer29.4CTLA4, TPI1, HSPD1, TNFRSF1A
7arthritis29.0CTLA4, IL10, CXCL10, HSPD1, TNFRSF1A
8rheumatoid arthritis29.0TNFRSF1A, HSPD1, CXCL10, IL10, CTLA4
9vulvovaginitis10.4HSPD1
10meningitis10.4CXCL10
11trachoma10.4HSPD1
12blastomycosis10.4
13histoplasmosis10.4
14pulmonary tuberculosis10.2
15arthropathy10.2CTLA4, CXCL10
16behcet's disease10.2CTLA4, HSPD1
17autoimmune hepatitis10.2CTLA4, HSPD1
18connective tissue disease10.2CTLA4, IL10
19dermatitis10.2CTLA4, CXCL10
20acquired immunodeficiency syndrome10.2
21lobomycosis10.2
22cervicitis10.2
23laryngitis10.2
24prostatitis10.2
25primary biliary cirrhosis10.2CTLA4, HSPD1
26myasthenia gravis10.2IL10, CTLA4
27lepromatous leprosy10.1IL10, HSPD1
28atopy10.1IL10, CTLA4
29plasmodium falciparum malaria10.1IL10, TPI1
30stenotrophomonas maltophilia10.1
31hypercalcemia10.1
32esophagitis10.1
33gingivitis10.1
34osteomyelitis10.1
35sarcoma10.1
36mycetoma10.1
37graves' disease10.1CXCL10, CTLA4
38allergic rhinitis10.1CTLA4, IL10
39periodontal disease10.0CTLA4, CXCL10, HSPD1
40tetanus10.0IL10, HSPD1
41spondyloarthropathy 110.0TNFRSF1A, HSPD1
42hepatitis b10.0CTLA4, IL10, CXCL10
43common variable immunodeficiency10.0IL10, TNFRSF1A
44colitis10.0CXCL10, IL10, CTLA4
45leishmaniasis10.0IL10, TNFRSF1A
46atopic dermatitis10.0CTLA4, IL10, CXCL10
47neutropenia10.0CXCL10, TNFRSF1A
48ulcerative colitis10.0CXCL10, IL10, CTLA4
49allergic asthma10.0CTLA4, IL10
50chronic lymphocytic leukemia10.0CTLA4, TNFRSF1A

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to paracoccidioidomycosis

Symptoms for Paracoccidioidomycosis

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Drugs & Therapeutics for Paracoccidioidomycosis

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Drug clinical trials:

Search ClinicalTrials for Paracoccidioidomycosis

Search NIH Clinical Center for Paracoccidioidomycosis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Paracoccidioidomycosis

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Anatomical Context for Paracoccidioidomycosis

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MalaCards organs/tissues related to Paracoccidioidomycosis:

31
Bone, Lung, Skin, Lymph node, T cells, Testes, Monocytes, Bone marrow, Prostate, Neutrophil, Adrenal gland, Spleen, Thymus, Brain, Spinal cord, Colon, Myeloid, B cells, Tongue

FMA organs/tissues related to Paracoccidioidomycosis:

14
Mucosa, Lymph nodes, Bone, Skin or

Animal Models for Paracoccidioidomycosis or affiliated genes

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MGI Mouse Phenotypes related to Paracoccidioidomycosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2CTLA4, IL10, CXCL10, TNFRSF1A
2MP:00053977.6TNFRSF1A, TPI1, CXCL10, IL10, CTLA4
3MP:00053877.5TNFRSF1A, TPI1, CXCL10, IL10, CTLA4
4MP:00053767.3TNFRSF1A, TPI1, CXCL10, IL10, CTLA4
5MP:00107687.2CTLA4, IL10, CXCL10, TPI1, HSPD1, TNFRSF1A

Publications for Paracoccidioidomycosis

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Articles related to Paracoccidioidomycosis:

(show top 50)    (show all 528)
idTitleAuthorsYear
1
Serum antibody levels correlate with oral fungal cell numbers and influence the patients' response to chronic paracoccidioidomycosis. (25851750)
2015
2
Prevalence of paracoccidioidomycosis infection by intradermal reaction in rural areas in Alfenas, Minas Gerais, Brazil. (25076426)
2014
3
The role of leukotriene B4 in early stages of experimental paracoccidioidomycosis induced in phenotypically selected mouse strains. (23534453)
2013
4
Paracoccidioidomycosis simulating a soft tissue tumor. (24261836)
2013
5
The pivotal role of 5-lipoxygenase-derived LTB4 in controlling pulmonary paracoccidioidomycosis. (23991239)
2013
6
Chronic paracoccidioidomycosis of the intestine as single organ involvement points to an alternative pathogenesis of the mycosis. (23982286)
2013
7
The left lung is preferentially targeted during experimental paracoccidioidomycosis in C57BL/6 mice. (24141611)
2013
8
Serological survey of paracoccidioidomycosis in cats. (23912468)
2013
9
Regulatory T cells in cutaneous lesions of patients withA Paracoccidioidomycosis. (24107311)
2013
10
Osteomyelitis and pyoarthritis resulting from local paracoccidioidomycosis in an immunocompetent patient: a case report. (23043817)
2012
11
Synchronous oral paracoccidioidomycosis and esophageal carcinoma. (22371017)
2012
12
Paracoccidioidomycosis: high-resolution computed tomography-pathologic correlation. (19608361)
2011
13
Seropositive antiaquaporin-4 antibody associated with multisegmental myelitis in a patient with paracoccidioidomycosis. (21803375)
2011
14
Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis. (22046142)
2011
15
Analysis of invariant natural killer T cells in human paracoccidioidomycosis. (21805204)
2011
16
Gastrointestinal paracoccidioidomycosis: an overview. (20975575)
2011
17
Paracoccidioidomycosis in a dog: case report of generalized lymphadenomegaly. (21424604)
2011
18
Histoplasmosis and paracoccidioidomycosis in a non-endemic area: a review of cases and diagnosis. (21199139)
2011
19
Altered ex vivo expression of caspase 8, caspase 9, and Bcl-2 is associated with T-cell hyporeactivity in patients with paracoccidioidomycosis. (19386797)
2009
20
Oral paracoccidioidomycosis and pulmonary tuberculosis co-infection: relevance of oral biopsy in establishing the diagnosis and therapeutic approach. (18650110)
2009
21
Inducible nitric oxide synthase-deficient mice show exacerbated inflammatory process and high production of both Th1 and Th2 cytokines during paracoccidioidomycosis. (19063988)
2009
22
Hypercalcemia in a patient with disseminated paracoccidioidomycosis: a case report. (18691418)
2008
23
Experimental paracoccidioidomycosis: alternative therapy with ajoene, compound from Allium sativum, associated with sulfamethoxazole/trimethoprim. (18324489)
2008
24
Use of recombinant gp43 isoforms expressed in Pichia pastoris for diagnosis of paracoccidioidomycosis. (18235042)
2008
25
Characterization of inflammatory cells in oral paracoccidioidomycosis. (17577332)
2007
26
An open-label comparative pilot study of oral voriconazole and itraconazole for long-term treatment of paracoccidioidomycosis. (17990229)
2007
27
Neutrophil role in pulmonary paracoccidioidomycosis depends on the resistance pattern of hosts. (16603588)
2006
28
Infiltrative myelopathy by paracoccidioidomycosis. A review and report of nine cases with emphasis on bone marrow morphology. (16487359)
2006
29
The role of interleukin-10 in the differential expression of interleukin-12p70 and its beta2 receptor on patients with active or treated paracoccidioidomycosis and healthy infected subjects. (15596413)
2005
30
Absence of interleukin-4 determines less severe pulmonary paracoccidioidomycosis associated with impaired Th2 response. (15039362)
2004
31
Paracoccidioidomycosis in a woman with idiopathic hirsutism. (15487322)
2004
32
Paracoccidioidomycosis associated with human immunodeficiency virus infection. Report of 10 cases. (12964719)
2003
33
Paracoccidioidomycosis of the mouth: an emerging deep mycosis. (14530306)
2003
34
Unique adrenal gland imaging features in Addison's disease caused by paracoccidioidomycosis. (14573459)
2003
35
Dendritic cells and pattern of cytokines in paracoccidioidomycosis skin lesions. (12652191)
2003
36
Paracoccidioidomycosis mortality in Brazil (1980-1995). (12244377)
2002
37
Anti-gp43 antibodies in the cerebrospinal fluid of patients with central nervous system involvement by paracoccidioidomycosis. (12472279)
2002
38
Cytokines and lymphocyte proliferation in juvenile and adult forms of paracoccidioidomycosis: comparison with infected and non-infected controls. (11880044)
2002
39
Paracoccidioidomycosis: report of 2 cases mimicking squamous cell carcinoma. (12424456)
2002
40
Levels of specific antigen (gp43), specific antibodies, and antigen-antibody complexes in saliva and serum of paracoccidioidomycosis patients. (12054053)
2001
41
Canine paracoccidioidomycosis: a seroepidemiologic study. (11446531)
2001
42
Fibrotic sequelae in pulmonary paracoccidioidomycosis: histopathological aspects in BALB/c mice infected with viable and non-viable paracoccidioides brasiliensis propagules. (10810319)
2000
43
DNA-based vaccination against murine paracoccidioidomycosis using the gp43 gene from paracoccidioides brasiliensis. (10825609)
2000
44
Central nervous system paracoccidioidomycosis. Report of a case successfully treated with itraconazol. (10968887)
2000
45
Experimental paracoccidioidomycosis of the Syrian hamster: fungicidal activity and production of inflammatory cytokines by macrophages. (10746228)
2000
46
Endemic regions of paracoccidioidomycosis in Brazil: a clinical and epidemiologic study of 584 cases in the southeast region. (10497977)
1999
47
Hypercalcaemia and paracoccidioidomycosis. (9764330)
1998
48
Aspergillus fumigatus fungus ball in a patient with healed paracoccidioidomycosis. (9431402)
1997
49
The role of somatic structure of the fungus Paracoccidioides brasiliensis upon B cell activation in experimental paracoccidioidomycosis. (7648716)
1995
50
Paracoccidioidomycosis and its etiologic agent Paracoccidioides brasiliensis. (8509955)
1993

Variations for Paracoccidioidomycosis

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Expression for genes affiliated with Paracoccidioidomycosis

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Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for genes affiliated with Paracoccidioidomycosis

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Pathways related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.2CXCL10, TNFRSF1A
29.2CXCL10, TNFRSF1A
3
Show member pathways
9.0IL10, TNFRSF1A
4
Show member pathways
8.6TNFRSF1A, CXCL10, IL10
5
Show member pathways
8.6TNFRSF1A, CXCL10, IL10
6
Show member pathways
8.6TNFRSF1A, CXCL10, IL10
7
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.6TNFRSF1A, CXCL10, IL10
88.5IL10, HSPD1, TNFRSF1A
9
Show member pathways
8.1CTLA4, IL10, HSPD1, TNFRSF1A

Compounds for genes affiliated with Paracoccidioidomycosis

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Compounds related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1glatiramer acetate43 1210.8IL10, CTLA4
2p 277439.8IL10, HSPD1
3bifidobacterium439.7HSPD1, IL10
4indoleamine439.7CTLA4, IL10
5toxin-1439.7IL10, HSPD1
6tuberculin439.7HSPD1, IL10
7groalpha439.6CXCL10, IL10
8isocitrate439.6HSPD1, TPI1
9con a439.6IL10, CTLA4
10polymyxin b439.6IL10, HSPD1
11iodine43 2410.5TNFRSF1A, CTLA4
122,5-oligoadenylate439.5CXCL10, IL10
13il 10439.4CTLA4, IL10, CXCL10
14allergens439.4CXCL10, IL10, CTLA4
15blys439.4IL10, TNFRSF1A
16polyinosinic-polycytidylic acid439.4CXCL10, IL10
17tacrolimus43 49 1211.4CXCL10, IL10, CTLA4
18adalimumab43 49 1211.3TNFRSF1A, IL10
19vitamin d439.2CXCL10, IL10, CTLA4
20okt3439.2TNFRSF1A, IL10
21manganese superoxide439.0TNFRSF1A, HSPD1, TPI1
22thalidomide43 49 59 1212.0TNFRSF1A, IL10, CTLA4
23tgf beta1439.0CTLA4, IL10, TNFRSF1A
24ionomycin439.0TNFRSF1A, IL10, CTLA4
25neopterin439.0IL10, CXCL10, TNFRSF1A
26chloroquine43 2 49 28 1213.0TNFRSF1A, CXCL10, IL10
27methotrexate49 43 1211.0CTLA4, IL10, TNFRSF1A
28etanercept43 49 1210.7TNFRSF1A, IL10
29phosphatidylinositol438.6TNFRSF1A, HSPD1, CXCL10, CTLA4
30paraffin438.6IL10, HSPD1, TNFRSF1A
31infliximab43 49 1210.6TNFRSF1A, CXCL10, IL10, CTLA4
32alanine438.6TNFRSF1A, HSPD1, CXCL10, CTLA4
33superoxide43 249.6TPI1, HSPD1, TNFRSF1A
34estrogen438.6CTLA4, CXCL10, HSPD1, TNFRSF1A
35creatinine438.6TNFRSF1A, HSPD1, TPI1, CXCL10
36glutamate438.6TNFRSF1A, HSPD1, TPI1, CTLA4
37cyclosporin a43 28 5910.5CTLA4, IL10, HSPD1, TNFRSF1A
38cysteine438.5CTLA4, TPI1, HSPD1, TNFRSF1A
39endotoxin438.5TNFRSF1A, HSPD1, CXCL10, IL10
40pge2438.5IL10, CXCL10, TNFRSF1A
41atp43 289.5TNFRSF1A, HSPD1, TPI1, CXCL10
42cycloheximide438.5IL10, CXCL10, HSPD1, TNFRSF1A
43vegf438.4IL10, CXCL10, HSPD1, TNFRSF1A
44aspartate438.4TNFRSF1A, HSPD1, TPI1, IL10
45cholesterol43 28 24 1211.2CTLA4, CXCL10, TPI1, HSPD1, TNFRSF1A
46glucose438.2TNFRSF1A, HSPD1, TPI1, CXCL10, CTLA4
47lipid438.2TNFRSF1A, HSPD1, TPI1, CXCL10, CTLA4
48tyrosine438.1TNFRSF1A, HSPD1, TPI1, CXCL10, CTLA4
49rantes438.1CTLA4, IL10, CXCL10, HSPD1, TNFRSF1A
50dexamethasone43 49 28 1211.1TNFRSF1A, HSPD1, CXCL10, IL10, CTLA4

GO Terms for genes affiliated with Paracoccidioidomycosis

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Cellular components related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.5IL10, CXCL10, TPI1, HSPD1, TNFRSF1A

Biological processes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of B cell proliferationGO:00308899.7CTLA4, IL10
2negative regulation of T cell proliferationGO:00421309.5IL10, CTLA4
3B cell proliferationGO:00421009.4IL10, HSPD1
4cellular response to estradiol stimulusGO:00713929.2IL10, TNFRSF1A
5negative regulation of interleukin-6 productionGO:00327159.2IL10, TNFRSF1A
6response to lipopolysaccharideGO:00324969.2CXCL10, TNFRSF1A
7defense response to bacteriumGO:00427428.9TNFRSF1A, IL10
8inflammatory responseGO:00069548.7TNFRSF1A, CXCL10, IL10
9negative regulation of apoptotic processGO:00430668.5IL10, HSPD1, TNFRSF1A
10positive regulation of transcription from RNA polymerase II promoterGO:00459448.3IL10, CXCL10, TNFRSF1A

Products for genes affiliated with Paracoccidioidomycosis

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Sources for Paracoccidioidomycosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet