MCID: PRC002
MIFTS: 59

Paracoccidioidomycosis

Categories: Rare diseases, Infectious diseases, Immune diseases

Aliases & Classifications for Paracoccidioidomycosis

MalaCards integrated aliases for Paracoccidioidomycosis:

Name: Paracoccidioidomycosis 12 72 49 55 51 41 14 69
Mucocutaneous-Lymphangitic Paracoccidioidomycosis 12
Paracoccidioidomycosis, Unspecified 12
Lutz-Splendore-Almeida Disease 49
South American Blastomycosis 49
Paracoccidioidomycosis Nos 12
Paracoccidioidal Granuloma 49
Paracoccidioidal Mycosis 12
Lobo Disease 49
Lobomycosis 69
Pcm 49

Characteristics:

Orphanet epidemiological data:

55
paracoccidioidomycosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12662
ICD10 32 B41 B41.9
ICD9CM 34 116.1
MeSH 41 D010229
NCIt 46 C34891
Orphanet 55 ORPHA73260
MESH via Orphanet 42 D010229
UMLS via Orphanet 70 C0030409
ICD10 via Orphanet 33 B41.0 B41.7 B41.8 more
UMLS 69 C0030409

Summaries for Paracoccidioidomycosis

Disease Ontology : 12 A primary systemic mycosis that results_in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in Paracoccidioides brasiliensis.

MalaCards based summary : Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to laryngitis and allergic hypersensitivity disease. An important gene associated with Paracoccidioidomycosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include mucosa, lymph nodes and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Paracoccidioidomycosis (PCM) (also known as \"Brazilian blastomycosis,\" \"South American... more...

Related Diseases for Paracoccidioidomycosis

Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 380)
# Related Disease Score Top Affiliating Genes
1 laryngitis 30.0 IL6 TNF
2 allergic hypersensitivity disease 30.0 IFNG IL10 IL4 IL5
3 prostatitis 29.9 IL10 IL6 TNF
4 gingivitis 29.7 IL4 IL6 TNF
5 hepatitis c 29.6 CXCL10 IFNG IL10 TNF
6 osteomyelitis 29.6 IFNG IL10 IL6 TNF
7 penicilliosis 29.1 CD86 TLR2 TLR4 TNF
8 peritonitis 28.9 IFNG IL10 IL6 TLR2 TNF
9 acquired immunodeficiency syndrome 28.8 IFNG IL10 IL2 IL6 TNF
10 crohn's disease 28.8 IFNG IL10 IL6 TLR4 TNF
11 arthritis 28.7 IFNG IL10 IL18 IL6 TNF
12 mycobacterium tuberculosis 1 28.4 CXCL10 IFNG IL10 IL18 IL4 TLR2
13 schistosomiasis 28.3 IFNG IL10 IL2 IL4 IL5 TNF
14 leprosy 3 28.3 IFNG IL10 IL2 IL4 TLR2 TNF
15 pneumonia 28.2 IL10 IL5 IL6 TLR2 TLR4 TNF
16 pulmonary tuberculosis 28.1 IFNG IL10 IL18 IL2 IL4 TLR2
17 periodontitis 27.9 IFNG IL10 IL4 IL6 TLR2 TLR4
18 systemic lupus erythematosus 25.8 CD86 CTLA4 CXCL10 IFNG IL10 IL18
19 rheumatoid arthritis 25.6 CD86 CTLA4 IFNG IL10 IL18 IL2
20 punctate inner choroidopathy 10.6 IL10 TNF
21 microscopic polyangiitis 10.5 IL10 TNF
22 multifocal choroiditis 10.5 IL10 TNF
23 transient hypogammaglobulinemia 10.5 IL10 TNF
24 staphylococcal toxic shock syndrome 10.5 IFNG TNF
25 choroiditis 10.5 IL10 TNF
26 mycoplasmal pneumonia 10.5 IFNG IL4
27 chronic beryllium disease 10.5 IFNG TNF
28 sporotrichosis 10.5 IFNG IL10
29 trichosporonosis 10.5 IFNG TNF
30 immunoglobulin a deficiency 1 10.5 IL10 IL4
31 autoimmune pancreatitis 10.5 CTLA4 TNF
32 eosinophilic fasciitis 10.5 IFNG IL5
33 mucocutaneous leishmaniasis 10.4 IL10 TNF
34 retinitis pigmentosa 22 10.4 IL10 IL4
35 idiopathic achalasia 10.4 IL10 TNF
36 necatoriasis 10.4 IL10 IL5
37 aseptic meningitis 10.4 IFNG IL10 TNF
38 neurosyphilis 10.4 IL10 TLR2
39 tropical endomyocardial fibrosis 10.4 IL10 IL4 TNF
40 tungiasis 10.4 IL10 IL4 TNF
41 endomyocardial fibrosis 10.4 IL10 IL4 TNF
42 severe hemophilia a 10.4 CTLA4 IL10 TNF
43 hyperlucent lung 10.4 IFNG IL10 IL4
44 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4 CTLA4 IFNG IL10
45 peanut allergy 10.4 CXCL10 IFNG IL10
46 baylisascariasis 10.4 IFNG IL10 IL4
47 primary peritoneal carcinoma 10.4 CXCL10 IFNG IL10
48 buruli ulcer 10.3 IFNG IL10 IL4
49 trichuriasis 10.3 IL10 TNF
50 rheumatic disease 10.3 IFNG IL10 TNF

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to Paracoccidioidomycosis

Symptoms & Phenotypes for Paracoccidioidomycosis

MGI Mouse Phenotypes related to Paracoccidioidomycosis:

43 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.34 CTLA4 CXCL10 IFNG IL10 IL18 IL2
2 homeostasis/metabolism MP:0005376 10.32 TLR4 TNF CD86 CTLA4 CXCL10 IFNG
3 cellular MP:0005384 10.31 CD86 CXCL10 IFNG IL10 IL18 IL2
4 immune system MP:0005387 10.31 CD86 CTLA4 CXCL10 IFNG IL10 IL18
5 digestive/alimentary MP:0005381 10.3 CTLA4 IFNG IL10 IL18 IL2 IL4
6 behavior/neurological MP:0005386 10.28 CD86 IFNG IL10 IL18 IL2 IL5
7 cardiovascular system MP:0005385 10.27 CTLA4 CXCL10 IFNG IL10 IL18 IL2
8 growth/size/body region MP:0005378 10.24 TNF IFNG IL10 IL18 IL2 IL4
9 endocrine/exocrine gland MP:0005379 10.2 CD86 CTLA4 IFNG IL10 IL2 IL4
10 mortality/aging MP:0010768 10.17 CTLA4 CXCL10 IFNG IL10 IL18 IL2
11 liver/biliary system MP:0005370 10.16 IL4 IL5 IL6 TLR2 TLR4 TNF
12 integument MP:0010771 10.13 TNF CTLA4 IFNG IL10 IL18 IL4
13 nervous system MP:0003631 10.02 CD86 CXCL10 IFNG IL10 IL18 IL4
14 muscle MP:0005369 10.01 CD86 IFNG IL10 IL18 IL6 TLR2
15 neoplasm MP:0002006 9.97 IFNG IL10 IL2 IL5 IL6 TLR2
16 reproductive system MP:0005389 9.86 IFNG IL10 IL2 IL4 IL5 IL6
17 respiratory system MP:0005388 9.85 TNF CTLA4 IFNG IL10 IL2 IL4
18 skeleton MP:0005390 9.56 CTLA4 IFNG IL10 IL4 IL6 TLR2
19 vision/eye MP:0005391 9.23 IFNG IL10 IL18 IL2 IL4 IL6

Drugs & Therapeutics for Paracoccidioidomycosis

Search Clinical Trials , NIH Clinical Center for Paracoccidioidomycosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: paracoccidioidomycosis

Genetic Tests for Paracoccidioidomycosis

Anatomical Context for Paracoccidioidomycosis

The Foundational Model of Anatomy Ontology organs/tissues related to Paracoccidioidomycosis:

18
Mucosa, Lymph Nodes, Bone, Skin Or

MalaCards organs/tissues related to Paracoccidioidomycosis:

38
Bone, Lung, Skin, Lymph Node, T Cells, Testes, Monocytes

Publications for Paracoccidioidomycosis

Articles related to Paracoccidioidomycosis:

(show top 50) (show all 627)
# Title Authors Year
1
Case Report: Misleading Serological Diagnosis of Paracoccidioidomycosis in a Young Patient with the Acute Form Disease:<i>Paracoccidioides brasiliensis</i>or<i>Paracoccidioides lutzii</i>? ( 29405111 )
2018
2
Emergence of acute/subacute infant-juvenile paracoccidioidomycosis in Northeast Argentina: Effect of climatic and anthropogenic changes? ( 29346653 )
2018
3
A case of paracoccidioidomycosis due to<i>Paracoccidioides lutzii</i>presenting sarcoid-like form. ( 29159027 )
2018
4
Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 plus HIV co-infection. ( 29412355 )
2018
5
Disseminated paracoccidioidomycosis prediagnosticated as neoplasm: An important challenge in diagnosis using rt-PCR. ( 29071205 )
2018
6
NOD-Like Receptor P3 Inflammasome Controls Protective Th1/Th17 Immunity against Pulmonary Paracoccidioidomycosis. ( 28740491 )
2017
7
Peptide Vaccine Against Paracoccidioidomycosis. ( 28584987 )
2017
8
Sarcoid-like cutaneous lesions in chronic adult paracoccidioidomycosis: report of two cases. ( 28591264 )
2017
9
New Trends in Paracoccidioidomycosis Epidemiology. ( 29371520 )
2017
10
Altered distribution of peripheral blood dendritic cell subsets in patients with pulmonary paracoccidioidomycosis. ( 28606816 )
2017
11
Increased peripheral blood TCD4+ counts and serum SP-D levels in patients with chronic paracoccidioidomycosis, during and after antifungal therapy. ( 29091134 )
2017
12
Itraconazole in combination with neutrophil depletion reduces the expression of genes related to pulmonary fibrosis in an experimental model of paracoccidioidomycosis. ( 29420794 )
2017
13
Paracoccidioidomycosis: Epidemiological and Clinical Aspects in 546 Cases Studied in the State of EspA-rito Santo, Brazil. ( 28749757 )
2017
14
Acute Paracoccidioidomycosis in a 40-Year-Old Man: A Case Report and Literature Review. ( 28900882 )
2017
15
Ophthalmic Paracoccidioidomycosis. ( 29187269 )
2017
16
Paracoccidioidomycosis: level of pulmonary sequelae in high resolution computed tomography images from patients of two endemic regions of Brazil. ( 28811998 )
2017
17
Th17-Inducing Cytokines IL-6 and IL-23 Are Crucial for Granuloma Formation during Experimental Paracoccidioidomycosis. ( 28871251 )
2017
18
Opinion: Paracoccidioidomycosis and HIV Immune Recovery Inflammatory Syndrome. ( 29159660 )
2017
19
Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43A kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis. ( 28646277 )
2017
20
Subtractive phage display selection for screening and identification of peptide sequences with potential use in serodiagnosis of paracoccidioidomycosis caused by Paracoccidioides brasiliensis. ( 28796894 )
2017
21
Therapeutic treatment with scFv-PLGA nanoparticles decreases pulmonary fungal load in a murine model of paracoccidioidomycosis. ( 28951317 )
2017
22
Brazilian guidelines for the clinical management of paracoccidioidomycosis. ( 28746570 )
2017
23
Voice disorders in residual paracoccidioidomycosis in upper airways and digestive tract. ( 28583268 )
2017
24
Autopsy and biopsy study of paracoccidioidomycosis and neuroparacoccidioidomycosis with and without HIV co-infection. ( 29274088 )
2017
25
Therapeutic Response in Adult Patients with Nonsevere Chronic Paracoccidioidomycosis Treated with Sulfamethoxazole-Trimethoprim: A Retrospective Study. ( 28722596 )
2017
26
Erratum: Brazilian guidelines for the clinical management of paracoccidioidomycosis. ( 29044299 )
2017
27
Paracoccidioidomycosis ceti in an Atlantic bottlenose dolphin (Tursiops truncatus), Brazil. ( 29205896 )
2017
28
Bone marrow-derived mesenchymal stem cells transplantation alters the course of experimental paracoccidioidomycosis by exacerbating the chronic pulmonary inflammatory response. ( 29253200 )
2017
29
Paracoccidioidomycosis after Highway Construction, Rio de Janeiro, Brazil. ( 29048286 )
2017
30
Hepatic Disease with Portal Hypertension and Acute Juvenile Paracoccidioidomycosis: A Report of Two Cases and Literature Review. ( 28577123 )
2017
31
Dendritic Cells Primed with Paracoccidioides brasiliensis Peptide P10 Are Therapeutic in Immunosuppressed Mice with Paracoccidioidomycosis. ( 28659882 )
2017
32
Paracoccidioidomycosis with sarcoid-like lesions:a diagnostic challenge. ( 28562770 )
2017
33
Case report of myeloperoxidase deficiency associated with disseminated paracoccidioidomycosis and peritoneal tuberculosis. ( 28954085 )
2017
34
Oral paracoccidioidomycosis in a single-center retrospective analysis from a Brazilian southeastern population. ( 29153538 )
2017
35
Th1-Inducing Agents in Prophylaxis and Therapy for Paracoccidioidomycosis. ( 28584990 )
2017
36
Paracoccidioidomycosis: Current Perspectives from Brazil. ( 29204222 )
2017
37
Evaluation of the hepatobiliary system in patients with paracoccidioidomycosis treated with cotrimoxazole or itraconazole. ( 29420819 )
2017
38
DNAhsp65 Vaccine as Therapy against Paracoccidioidomycosis. ( 28584985 )
2017
39
Spontaneous pneumothorax in paracoccidioidomycosis patients from an endemic area in Midwestern Brazil. ( 27687259 )
2017
40
Hypereosinophilia Secondary to Disseminated Paracoccidioidomycosis. ( 29042530 )
2017
41
Impaired anti-fibrotic effect of bone marrow-derived mesenchymal stem cell in a mouse model of pulmonary paracoccidioidomycosis. ( 29040281 )
2017
42
Oral Paracoccidioidomycosis Granulomas are Predominantly Populated by CD163+ Multinucleated Giant Cells. ( 27236303 )
2016
43
Photodynamic inactivation of oral paracoccidioidomycosis affecting woman with systemic lupus erythematosus: an unusual case report. ( 28012807 )
2016
44
Polymorphisms on IFNG, IL12B and IL12RB1 genes and paracoccidioidomycosis in the Brazilian population. ( 27223631 )
2016
45
Paracoccidioides brasiliensis PS2: First Autochthonous Paracoccidioidomycosis Case Report in Rio de Janeiro, Brazil, and Literature Review. ( 27161127 )
2016
46
Current strategies for diagnosis of paracoccidioidomycosis and prospects of methods based on gold nanoparticles. ( 27416765 )
2016
47
Real Time Polymerase Chain Reaction (rt-PCR): A New Patent to diagnostic purposes for paracoccidioidomycosis. ( 27593543 )
2016
48
CHYLOTHORAX IN PARACOCCIDIOIDOMYCOSIS. ( 27410917 )
2016
49
Correction: Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis. ( 27992575 )
2016
50
Antifungal Activity of Amphotericin B Conjugated to Nanosized Magnetite in the Treatment of Paracoccidioidomycosis. ( 27303789 )
2016

Variations for Paracoccidioidomycosis

Expression for Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for Paracoccidioidomycosis

Pathways related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 CD86 CTLA4 CXCL10 IFNG IL10 IL18
2
Show member pathways
13.82 CXCL10 IL10 IL18 IL2 IL4 IL5
3
Show member pathways
13.73 CXCL10 IFNG IL10 IL18 IL2 IL4
4
Show member pathways
13.57 IFNG IL10 IL18 IL2 IL4 IL5
5
Show member pathways
13.51 CXCL10 IL10 IL18 IL2 IL4 IL5
6
Show member pathways
13.46 CD86 CXCL10 IFNG IL10 IL18 IL2
7
Show member pathways
13.37 CXCL10 IL10 IL18 IL2 IL4 IL5
8
Show member pathways
13.21 IFNG IL2 IL4 TLR2 TLR4 TNF
9
Show member pathways
13.03 IL2 IL4 IL6 TLR2 TLR4 TNF
10
Show member pathways
12.97 IL18 IL6 TLR2 TLR4 TNF
11
Show member pathways
12.97 CD86 CTLA4 IFNG IL10 IL2 IL4
12
Show member pathways
12.91 CXCL10 IFNG IL18 IL2 IL4 IL6
13 12.87 IFNG IL2 IL4 IL5 IL6
14
Show member pathways
12.78 CD86 IFNG IL10 IL18 IL2 IL4
15
Show member pathways
12.77 CXCL10 IFNG IL18 IL6 TNF
16
Show member pathways
12.75 IL2 IL6 TLR2 TLR4 TNF
17 12.71 CTLA4 CXCL10 IFNG IL10 IL2 IL4
18
Show member pathways
12.7 IFNG IL10 IL18 IL2 IL6 TNF
19
Show member pathways
12.64 CD86 IL6 TLR2 TLR4 TNF
20
Show member pathways
12.62 CD86 CXCL10 IFNG IL10 IL2 IL6
21
Show member pathways
12.6 CD86 IFNG IL10 IL18 IL2 IL4
22
Show member pathways
12.57 CTLA4 IFNG IL10 IL2 IL4 IL5
23
Show member pathways
12.53 IFNG IL2 IL4 TNF
24
Show member pathways
12.52 IFNG IL10 IL2 IL4 IL5 IL6
25
Show member pathways
12.51 CXCL10 IFNG IL4 IL5 IL6 TLR2
26
Show member pathways
12.44 IFNG IL2 IL4 IL6 TNF
27
Show member pathways
12.42 IFNG IL10 IL4 TLR2 TLR4 TNF
28 12.41 IFNG IL10 IL18 IL6 TLR2 TLR4
29
Show member pathways
12.35 CXCL10 IFNG IL4 IL6 TLR2 TLR4
30
Show member pathways
12.33 IFNG IL6 TLR4 TNF
31
Show member pathways
12.32 IL6 TLR2 TLR4 TNF
32 12.31 IFNG IL6 TLR2 TLR4 TNF
33
Show member pathways
12.27 IFNG IL10 IL18 IL2 IL4 IL5
34 12.17 CXCL10 IFNG IL2 IL4 IL6 TLR4
35 12.14 IL10 IL18 IL4 IL6 TNF
36
Show member pathways
12.12 IL2 IL5 TLR2 TLR4
37 12.1 CD86 IFNG IL10 IL2 IL4 IL5
38 12.09 IFNG IL10 IL6 TLR2 TLR4 TNF
39
Show member pathways
12.07 IFNG IL18 IL2 IL4
40
Show member pathways
12.05 CD86 IFNG IL4 IL6 TLR2 TLR4
41 12 IL4 IL5 IL6 TNF
42 11.99 IFNG IL2 IL4 IL5 IL6
43 11.96 CXCL10 IL6 TNF
44
Show member pathways
11.96 CTLA4 IFNG IL2 IL4 IL5 TNF
45 11.95 IFNG IL18 IL6 TLR4
46 11.94 IFNG IL10 IL2 IL6
47 11.94 IFNG IL10 IL2 IL6 TNF
48 11.94 IFNG IL10 IL18 IL2 IL4 IL5
49 11.93 IFNG IL6 TLR4
50
Show member pathways
11.93 CD86 IFNG IL10 IL18 IL2 IL6

GO Terms for Paracoccidioidomycosis

Cellular components related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CXCL10 IFNG IL10 IL18 IL2 IL4
2 external side of plasma membrane GO:0009897 9.46 CTLA4 CXCL10 TLR4 TNF
3 extracellular space GO:0005615 9.28 CXCL10 IFNG IL10 IL18 IL2 IL4

Biological processes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 CXCL10 IL10 IL18 IL2 IL4 IL6
2 adaptive immune response GO:0002250 9.96 CD86 CTLA4 IFNG IL2
3 response to lipopolysaccharide GO:0032496 9.96 CXCL10 IL10 TLR2 TLR4
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.94 IL6 TLR2 TLR4 TNF
5 response to virus GO:0009615 9.9 CXCL10 IFNG TNF
6 positive regulation of DNA binding transcription factor activity GO:0051091 9.9 IL10 IL5 IL6 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.89 IL6 TLR2 TNF
8 positive regulation of inflammatory response GO:0050729 9.87 IL18 IL2 TLR2 TLR4
9 response to glucocorticoid GO:0051384 9.86 IL10 IL6 TNF
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.86 IFNG IL18 IL2 IL6
11 positive regulation of T cell proliferation GO:0042102 9.85 IL2 IL4 IL6
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 IL18 IL6 TNF
13 cellular response to lipopolysaccharide GO:0071222 9.85 CXCL10 IL10 IL6 TLR4 TNF
14 humoral immune response GO:0006959 9.84 IFNG IL6 TNF
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IFNG TLR4 TNF
16 positive regulation of interleukin-6 production GO:0032755 9.83 IL6 TLR2 TLR4 TNF
17 positive regulation of interferon-gamma production GO:0032729 9.81 IL18 IL2 TLR4 TNF
18 positive regulation of interleukin-8 production GO:0032757 9.8 TLR2 TLR4 TNF
19 negative regulation of interleukin-6 production GO:0032715 9.79 IL10 TLR4 TNF
20 positive regulation of interleukin-12 production GO:0032735 9.78 IFNG TLR2 TLR4
21 positive regulation of B cell proliferation GO:0030890 9.78 IL2 IL4 IL5 TLR4
22 negative regulation of myoblast differentiation GO:0045662 9.77 CXCL10 IL18 TNF
23 inflammatory response GO:0006954 9.76 CXCL10 IL10 IL18 IL5 IL6 TLR2
24 regulation of regulatory T cell differentiation GO:0045589 9.75 CTLA4 IFNG IL2
25 positive regulation of JAK-STAT cascade GO:0046427 9.74 IL5 IL6
26 positive regulation of T cell differentiation GO:0045582 9.74 IL2 IL4
27 negative regulation of B cell proliferation GO:0030889 9.73 CTLA4 IL10
28 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IFNG TNF
29 positive regulation of macrophage activation GO:0043032 9.73 IL10 TLR4
30 negative regulation of growth of symbiont in host GO:0044130 9.73 IL10 TNF
31 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.73 TLR2 TLR4
32 positive regulation of interleukin-17 production GO:0032740 9.72 IL18 IL2
33 response to molecule of bacterial origin GO:0002237 9.72 IL10 TLR2
34 positive regulation of podosome assembly GO:0071803 9.72 IL5 TNF
35 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL10 TNF
36 I-kappaB phosphorylation GO:0007252 9.72 TLR2 TLR4
37 positive regulation of immunoglobulin secretion GO:0051024 9.72 IL2 IL5 IL6
38 regulation of cytokine secretion GO:0050707 9.71 TLR2 TLR4
39 T-helper 1 type immune response GO:0042088 9.71 IL18 TLR4
40 interferon-gamma production GO:0032609 9.71 IL18 TLR4
41 negative regulation of interleukin-17 production GO:0032700 9.71 IFNG TLR4
42 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 IL18 TLR2 TLR4 TNF
43 cellular response to lipoteichoic acid GO:0071223 9.7 TLR2 TLR4
44 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
45 positive regulation of isotype switching to IgG isotypes GO:0048304 9.7 IL2 IL4
46 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR4 TNF
47 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
48 positive regulation of T-helper 2 cell differentiation GO:0045630 9.69 CD86 IL18
49 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
50 positive regulation of tissue remodeling GO:0034105 9.68 IL18 IL2

Molecular functions related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 IL10 IL2 IL4 IL5 IL6
2 cytokine activity GO:0005125 9.28 CXCL10 IFNG IL10 IL18 IL2 IL4
3 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
4 protein binding GO:0005515 10.07 CD86 CTLA4 CXCL10 IFNG IL10 IL18

Sources for Paracoccidioidomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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