PCM
MCID: PRC002
MIFTS: 64

Paracoccidioidomycosis (PCM) malady

Infectious, Immune categories

Summaries for Paracoccidioidomycosis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in paracoccidioides brasiliensis.

MalaCards: Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to cystic fibrosis and insulin resistance. An important gene associated with Paracoccidioidomycosis is CXCL10 (chemokine (C-X-C motif) ligand 10), and among its related pathways are Cell adhesion molecules (CAMs) and Regulation by c-FLIP. The drugs ketoconazole and itraconazole and the compounds cyclosporin a and rantes have been mentioned in the context of this disorder. Affiliated tissues include mucosa, lymph nodes and bone, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Wikipedia:64 Paracoccidioidomycosis (also known as \"Brazilian blastomycosis,\" \"South American... more...

Aliases & Classifications for Paracoccidioidomycosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 49Orphanet, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Immune


Characteristics (Orphanet epidemiological data):

49
paracoccidioidomycosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

paracoccidioidomycosis 8 43 45 49 61
mucocutaneous-lymphangitic paracoccidioidomycosis 8
paracoccidioidomycosis, unspecified 8
lutz-splendore-almeida disease 43
south american blastomycosis 43
protein-energy malnutrition 61
paracoccidioidomycosis nos 8
paracoccidioidal granuloma 43
paracoccidioidal mycosis 8
lobo disease 43
pcm 43


External Ids:

Disease Ontology8 DOID:12662
NCIt40 C34891
MeSH35 D010229
ICD9CM27 116.1
MESH via Orphanet36 D010229
ICD10 via Orphanet26 B41
SNOMED-CT via Orphanet58 59925007
UMLS via Orphanet62 C0030409
ICD1025 B41, B41.9

Related Diseases for Paracoccidioidomycosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 215)
idRelated DiseaseScoreTop Affiliating Genes
1cystic fibrosis30.5TLR4
2insulin resistance30.5TNFRSF1A, TLR4
3tuberculosis30.5GSR, TPI1, IL10, CXCL9, CXCL10, MYD88
4deficiency anemia30.3GSR, TPI1, G6PD
5viral hepatitis30.3TNFRSF1A, FASLG, G6PD
6tetanus30.3HSPD1, CD28, IL10, IL5
7squamous cell carcinoma30.2CKS1B, FASLG, CTLA4, GLO1, CXCL9, TPI1
8vasculitis29.8CTLA4, HSPD1
9silicosis29.8FASLG
10septic shock29.8TLR4, TNFRSF1A, MYD88, IL10
11hepatitis c29.8TLR4, CTLA4, CD28, CXCL10, IL10, GSR
12arthritis29.8HSPD1, TLR4, TNFRSF1A, CTLA4, CXCL10, CXCL9
13kwashiorkor10.6
14protein c deficiency10.6
15marasmus10.5
16measles10.4
17blastomycosis10.4
18hepatitis e10.3
19biotin deficiency10.3
20protein s deficiency10.3
21lactose intolerance10.3
22cerebral malaria10.3
23acute leukemia10.3
24hepatitis a10.3
25protein r deficiency10.3
26protein-deficiency anemia10.2
27acute diarrhea10.2
28visceral leishmaniasis10.2
29giardiasis10.2
30ariboflavinosis10.2
31iron deficiency anemia10.2
32juvenile rheumatoid arthritis10.2
33hepatitis d10.2
34hyperinsulinism10.2
35anorexia nervosa10.2
36adult syndrome10.2
37alcoholic liver cirrhosis10.2
38alcoholic hepatitis10.2
39wilms tumor10.2
40fetal macrosomia10.2
41tuberculous meningitis10.2
42brain injury10.2
43cerebral atrophy10.2
44dysphagia10.2
45pancreatitis, chronic10.2
46homocysteine plasma level10.2
47riboflavin deficiency10.2
48blindness10.2
49brain ischemia10.2
50lobomycosis10.2

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to paracoccidioidomycosis

Clinical Features for Paracoccidioidomycosis

Drugs & Therapeutics for Paracoccidioidomycosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Paracoccidioidomycosis

Drug clinical trials:

Search ClinicalTrials for Paracoccidioidomycosis

Search NIH Clinical Center for Paracoccidioidomycosis

Search CenterWatch for Paracoccidioidomycosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Paracoccidioidomycosis

Anatomical Context for Paracoccidioidomycosis

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Paracoccidioidomycosis:

33
Bone marrow, Whole blood, Lymph node, Spleen, Thymus, Spinal cord, Small intestine, Colon, Lung, Adrenal gland, Skin, Prostate, Myeloid, Monocytes, T cells, B cells

FMA organs/tissues related to Paracoccidioidomycosis:

14
Mucosa, Lymph nodes, Bone, Skin or

Animal Models for Paracoccidioidomycosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Paracoccidioidomycosis

Sources:
51PubMed
See all sources

Articles related to Paracoccidioidomycosis:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Paracoccidioidomycosis simulating a soft tissue tumor. (24261836)
2013
2
Paracoccidioidomycosis: eco-epidemiology, taxonomy and clinical and therapeutic issues. (24020744)
2013
3
Endemic oral paracoccidioidomycosis: clinical presentation, management, and outcomes. (24184392)
2013
4
Extensive cutaneous lesions in paracoccidioidomycosis successfully treated with itraconazole and I^-glucan. (23621852)
2013
5
Lung cysts in chronic paracoccidioidomycosis. (23857700)
2013
6
Prostatic paracoccidioidomycosis with a fatal outcome: a case report. (23668825)
2013
7
Synchronous oral paracoccidioidomycosis and esophageal carcinoma. (22371017)
2012
8
Paracoccidioidomycosis in pregnancy: an atypical case report. (22964292)
2012
9
Chronic multifocal paracoccidioidomycosis in an immunocompetent adult. (22578295)
2012
10
Expanding the clinical and genetic spectrum of human CD40L deficiency: the occurrence of paracoccidioidomycosis and other unusual infections in Brazilian patients. (22193914)
2012
11
Gastrointestinal paracoccidioidomycosis: an overview. (20975575)
2011
12
Paracoccidioidomycosis in a patient with cervical cancer. (21738984)
2011
13
Small vessel vasculitis as first manifestation of paracoccidioidomycosis - case report. (22281916)
2011
14
Paracoccidioidomycosis: cells expressing IL17 and Foxp3 in cutaneous and mucosal lesions. (21296652)
2011
15
Paracoccidioidomycosis: description of two cases autochthonous in CearA!. (20428661)
2010
16
First description of a cluster of acute/subacute paracoccidioidomycosis cases and its association with a climatic anomaly. (20361032)
2010
17
Co-infection with paracoccidioidomycosis and human immunodeficiency virus: report of a case with esophageal involvement. (20519606)
2010
18
Serum levels of sTNF-R1, sTNF-R2 and CXCL9 correlate with disease activity in adult type paracoccidioidomycosis. (19083989)
2009
19
Experimental paracoccidioidomycosis: alternative therapy with ajoene, compound from Allium sativum, associated with sulfamethoxazole/trimethoprim. (18324489)
2008
20
Computed tomography findings in patients with tracheal paracoccidioidomycosis. (18830113)
2008
21
Paracoccidioidomycosis: infiltrated, sarcoid-like cutaneous lesions misinterpreted as tuberculoid leprosy. (18327487)
2008
22
Chloroquine is therapeutic in murine experimental model of paracoccidioidomycosis. (17456179)
2007
23
Flow-cytometric analysis of cytokine production in human paracoccidioidomycosis. (17045486)
2006
24
Increased apoptosis during the early phase of experimental paracoccidioidomycosis as a phenotypic marker of resistance. (17045508)
2006
25
Vinyl adhesive tape also effective for direct microscopy diagnosis of chromomycosis, lobomycosis, and paracoccidioidomycosis. (15878441)
2005
26
Paracoccidioides brasiliensis, paracoccidioidomycosis, and antifungal antibiotics. (16181141)
2005
27
Distribution of paracoccidioidomycosis: determination of ecologic correlates through spatial analyses. (15682640)
2004
28
Therapeutic activity of a killer peptide against experimental paracoccidioidomycosis. (15448128)
2004
29
Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome. (15286812)
2004
30
Unique adrenal gland imaging features in Addison's disease caused by paracoccidioidomycosis. (14573459)
2003
31
Central nervous system paracoccidioidomycosis: imaging findings in 17 cases. (12544236)
2003
32
Effect of cytokines on the in vitro fungicidal activity of monocytes from paracoccidioidomycosis patients. (12650768)
2003
33
Oral manifestations of paracoccidioidomycosis. Report of 21 cases from Argentina. (14622391)
2003
34
Randomized trial with itraconazole, ketoconazole and sulfadiazine in paracoccidioidomycosis. (12230222)
2002
35
Levels of specific antigen (gp43), specific antibodies, and antigen-antibody complexes in saliva and serum of paracoccidioidomycosis patients. (12054053)
2001
36
Exfoliative cytology: a helpful tool for the diagnosis of paracoccidioidomycosis. (11575871)
2001
37
Hard palate perforation: an unusual finding in paracoccidioidomycosis. (11454087)
2001
38
Oral paracoccidioidomycosis: a retrospective study of 62 Brazilian patients. (11354923)
2001
39
Morphological aspects of Paracoccidioides brasiliensis in lymph nodes: implications for the prolonged latency of paracoccidioidomycosis? (10975700)
2000
40
Study of pulmonary experimental paracoccidioidomycosis by analysis of bronchoalveolar lavage cells: resistant vs. susceptible mice. (9750339)
1998
41
Short report: use of the polymerase chain reaction to detect Paracoccidioides brasiliensis in murine paracoccidioidomycosis. (9502596)
1998
42
Paracoccidioidomycosis and AIDS: report of the first two Colombian cases. (10436658)
1998
43
Severe juvenile type paracoccidioidomycosis in an adult. (7650582)
1995
44
Natural killer cell activity in experimental paracoccidioidomycosis of the Syrian hamster. (7481468)
1995
45
Clinical and endoscopic findings in the mucosae of the upper respiratory and digestive tracts in post-treatment follow-up of paracoccidioidomycosis patients. (8729750)
1995
46
Chromosome aberrations in lymphocyte cultures from paracoccidioidomycosis patients. (7965490)
1994
47
Paracoccidioidomycosis: an update. (8472249)
1993
48
Oral paracoccidioidomycosis. A study of 36 South American patients. (8464610)
1993
49
Paracoccidioidomycosis (South American blastomycosis, Lutz's mycosis). (8125682)
1993
50
Immunosuppressive effect of paracoccidioidomycosis sera on the proliferative response of normal mononuclear cells. Identification of a Paracoccidioides brasiliensis 34-kDa polypeptide in circulating immune complexes. (1435949)
1992

Genetic Variations for Paracoccidioidomycosis

Expression for genes affiliated with Paracoccidioidomycosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for genes affiliated with Paracoccidioidomycosis

Sources:
30KEGG, 54Reactome, 53R&D Systems, 12EMD Millipore, 38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN
See all sources

Pathways related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2PDCD1, ICOS
2
Hide members
10.2TNFRSF1A, FASLG
3
Hide members
10.0IL10, FASLG, TNFRSF1A
410.0TLR4, MYD88, CXCL10
510.0FASLG, MYD88, IL10
610.0IL10, MYD88, TLR4
710.0IL10, MYD88, TLR4
8
Hide members
10.0IL5, CTLA4, FASLG
910.0MYD88, TNFRSF1A, TLR4
1010.0MYD88, TNFRSF1A, TLR4
1110.0HSPD1, TLR4, MYD88
1210.0HSPD1, FASLG, IL5
1310.0IL5, CD28, TNFRSF1A
1410.0CD28, CTLA4, TLR4
15
Immune response Bacterial infections in normal airways
Hide members
9.9MYD88, FASLG, TLR4
16
Hide members
9.9ICOS, PDCD1, CTLA4, CD28
17
Hide members
9.8CD28, CXCL10, IL12RB2, IL5
18
Hide members
9.8TLR4, TNFRSF1A, FASLG, MYD88
199.8TLR4, TNFRSF1A, MYD88, CD28
20
Hide members
9.8IL10, IL12RB2, CD28, TLR4
219.8HSPD1, TLR4, TNFRSF1A, MYD88, IL10
22
Hide members
9.7ICOS, PDCD1, CTLA4, CD28, IL5
23
Hide members
9.6TLR4, TNFRSF1A, MYD88, IL12RB2, IL10, IL5
24
Hide members
9.5TLR4, TNFRSF1A, FASLG, MYD88, CD28, CXCL10
25
Hide members
9.4TLR4, TNFRSF1A, FASLG, MYD88, CXCL10, CXCL9
26
Hide members
9.4TNFRSF1A, CD28, CXCL10, CXCL9, IL12RB2, IL10
27
Hide members
9.3TLR4, ICOS, PDCD1, CTLA4, MYD88, CD28
28
Hide members
9.1IL5, HSPD1, ICOS, TNFRSF1A, FASLG, CTLA4
29
Hide members
9.1TLR4, TNFRSF1A, FASLG, CD28, CXCL10, CXCL9
30
Hide members
9.0TLR4, TNFRSF1A, MYD88, CD28, CXCL10, CXCL9

Compounds for genes affiliated with Paracoccidioidomycosis

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1cyclosporin a45 29 6012.6CTLA4, CD28
2rantes4510.4TLR4, TNFRSF1A, FASLG
3glucose4510.4GLO1, FASLG, TPI1
4indomethacin45 60 29 1113.4GLO1, IL5, HSPD1
5infliximab45 50 1112.3IL10, TLR4, TNFRSF1A, CXCL10
6endotoxin4510.3TNFRSF1A, HSPD1, FASLG, MYD88
7cycloheximide4510.3HSPD1, CXCL10, FASLG
8aspartate4510.3FASLG, G6PD, HSPD1, TPI1
9glutamate4510.3TPI1, GLO1, TNFRSF1A, HSPD1
10con a4510.2IL5, IL10, CTLA4, CD28
11polyinosinic-polycytidylic acid4510.2IL5, IL10, CXCL10, TLR4
12imiquimod45 29 60 1113.2FASLG, IL10, IL5, TLR4
13oxygen45 2411.2CD28, TNFRSF1A, MYD88
14thalidomide45 50 60 1113.1TNFRSF1A, FASLG, CTLA4, IL5, IL10
15manganese superoxide4510.1GSR, TPI1, FASLG, TNFRSF1A, HSPD1
16tarc4510.1IL10, IL5, CXCL10, CXCL9
17glatiramer acetate45 1111.1CTLA4, IL10, IL5
18ifn-alpha4510.1FASLG, TLR4, CXCL10, CXCL9, IL10
19dexamethasone45 50 29 1113.1CXCL9, CTLA4, FASLG, TLR4, IL5
20h2o24510.1G6PD, FASLG, TNFRSF1A, HSPD1
21allergens4510.0TLR4, PDCD1, CTLA4, CXCL10, IL10, IL5
22ivig4510.0IL10, TNFRSF1A, IL5, FASLG
23il 104510.0CXCL9, IL10, IL5, TLR4, CXCL10, CTLA4
24chloroquine45 2 50 29 1114.0G6PD, TNFRSF1A, CXCL10, IL10, GSR, TLR4
25tgf beta14510.0IL10, TNFRSF1A, FASLG, CTLA4, TLR4
26ccl345 2911.0CXCL10, TLR4, CXCL9, IL10
27methylglyoxal45 2910.9GLO1, GSR, TPI1
28glyceraldehyde 3-phosphate459.9G6PD, HSPD1, TLR4, GLO1, TPI1, GSR
29methotrexate45 50 1111.9FASLG, TNFRSF1A, CTLA4, GLO1, IL5, GSR
30cyclophosphamide45 50 1111.9FASLG, G6PD, IL10, GSR, CXCL9
31n acetylcysteine459.8G6PD, FASLG, TNFRSF1A, GSR, HSPD1, TLR4
32tacrolimus45 50 1111.8CTLA4, CD28, CXCL10, IL10, IL5, FASLG
33ionomycin459.8IL10, IL5, CXCL9, CD28, CTLA4, FASLG
34superoxide45 2410.8TPI1, HSPD1, GSR, GLO1, G6PD, TNFRSF1A
35doxorubicin45 50 1111.8TNFRSF1A, HSPD1, GSR, GLO1, G6PD, FASLG
36ly294002459.7CTLA4, IL5, IL10, FASLG, TLR4, MYD88
37lactate459.7G6PD, GLO1, TPI1, HSPD1, FASLG, GSR
38creatinine459.7GLO1, HSPD1, TNFRSF1A, GSR, G6PD, TPI1
39adenylate459.7CXCL10, GLO1, IL5, FASLG, G6PD, TPI1
40alanine459.6FASLG, TNFRSF1A, TLR4, HSPD1, CXCL10, GLO1
41vegf459.6CXCL9, HSPD1, TNFRSF1A, FASLG, CXCL10, IL10
42guanidine hydrochloride459.6GSR, TPI1, G6PD, HSPD1
43nitric oxide45 11 2411.6TLR4, FASLG, MYD88, IL10, CXCL9, GLO1
44cholesterol45 29 11 2412.6CXCL10, HSPD1, TNFRSF1A, FASLG, TLR4, CTLA4
45atp45 2910.5MYD88, TLR4, HSPD1, TNFRSF1A, CXCL9, CXCL10
46phosphatidylinositol459.5HSPD1, TLR4, CD28, TNFRSF1A, FASLG, CXCL9
47genistein45 29 60 2 11 2414.4CXCL10, CD28, TLR4, FASLG, IL5, GSR
48cysteine459.3TNFRSF1A, GSR, IL5, CD28, GLO1, CTLA4
49lipid459.2GLO1, CXCL10, TPI1, GSR, CD28, MYD88
50tyrosine458.7TPI1, IL12RB2, CKS1B, HSPD1, CXCL9, PDCD1

GO Terms for genes affiliated with Paracoccidioidomycosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor complexGO:04669610.2TLR4, HSPD1
2extracellular spaceGO:0056159.3HSPD1, TNFRSF1A, FASLG, CXCL10, CXCL9, IL10
3integral to plasma membraneGO:0058879.1TLR4, ICOS, TNFRSF1A, FASLG, CTLA4, CD28
4external side of plasma membraneGO:0098979.0IL12RB2, TLR4, ICOS, PDCD1, FASLG, CTLA4

Biological processes related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.3TLR4, IL10
2negative regulation of interleukin-6 productionGO:03271510.3IL10, TNFRSF1A, TLR4
3positive regulation of interferon-gamma productionGO:03272910.3IL12RB2, TLR4, HSPD1
4interferon-gamma productionGO:03260910.3TLR4, IL12RB2
5positive regulation of interleukin-6 productionGO:03275510.3TLR4, HSPD1, MYD88
6glutathione metabolic processGO:00674910.2GLO1, GSR, G6PD
7negative regulation of B cell proliferationGO:03088910.2CTLA4, IL10
8cellular response to mechanical stimulusGO:07126010.2TLR4, TNFRSF1A, MYD88
9pentose-phosphate shuntGO:00609810.2G6PD, TPI1
10T cell costimulationGO:03129510.2CD28, PDCD1, ICOS, CTLA4
11cell surface receptor signaling pathwayGO:00716610.1MYD88, IL12RB2, CXCL10, CD28
12MyD88-dependent toll-like receptor signaling pathwayGO:00275510.1TLR4, HSPD1, MYD88
13positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.1TNFRSF1A, TLR4, FASLG, MYD88
14positive regulation of interferon-alpha productionGO:03272710.1TLR4, HSPD1
15response to lipopolysaccharideGO:03249610.0CXCL10, TNFRSF1A, TLR4, IL12RB2, FASLG
16cell-cell signalingGO:00726710.0FASLG, CXCL9, IL10, CXCL10
17B cell proliferationGO:0421009.9IL10, HSPD1
18inflammatory responseGO:0069549.9CXCL10, TNFRSF1A, CXCL9, IL10, IL5, MYD88
19immune responseGO:0069559.7CXCL10, TLR4, ICOS, FASLG, CTLA4, CXCL9

Molecular functions related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.8FASLG, CXCL9, IL10, IL5
2protein bindingGO:0055157.8HSPD1, CKS1B, EXOSC3, TLR4, PDCD1, TNFRSF1A

Products for genes affiliated with Paracoccidioidomycosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Paracoccidioidomycosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet