MCID: PRC002
MIFTS: 59

Paracoccidioidomycosis malady

Categories: Rare diseases, Infectious diseases, Immune diseases, Bone diseases, Skin diseases

Aliases & Classifications for Paracoccidioidomycosis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Paracoccidioidomycosis:

Name: Paracoccidioidomycosis 10 45 47 12 51 36 65
Mucocutaneous-Lymphangitic Paracoccidioidomycosis 10
Paracoccidioidomycosis, Unspecified 10
Lutz-Splendore-Almeida Disease 45
South American Blastomycosis 45
Paracoccidioidomycosis Nos 10
 
Paracoccidioidal Granuloma 45
Paracoccidioidal Mycosis 10
Lobo Disease 45
Lobomycosis 65
Pcm 45

Characteristics:

Orphanet epidemiological data:

51
paracoccidioidomycosis:
Inheritance: Not applicable; Age of onset: All ages

Classifications:



External Ids:

Disease Ontology10 DOID:12662
ICD1027 B41, B41.9
ICD9CM29 116.1
MeSH36 D010229
NCIt42 C34891
Orphanet51 73260
ICD10 via Orphanet28 B41.0, B41.7, B41.8 B41.9, more
MESH via Orphanet37 D010229
UMLS via Orphanet66 C0030409
UMLS65 C0030409

Summaries for Paracoccidioidomycosis

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Disease Ontology:10 A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in Paracoccidioides brasiliensis.

MalaCards based summary: Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to cryptococcosis and rheumatoid arthritis. An important gene associated with Paracoccidioidomycosis is IL10 (Interleukin 10), and among its related pathways are Canonical NF-kappaB pathway and IL4-mediated signaling events. The drugs itraconazole and ketoconazole have been mentioned in the context of this disorder. Affiliated tissues include mucosa, lymph nodes and bone, and related mouse phenotypes are vision/eye and respiratory system.

Wikipedia:68 Paracoccidioidomycosis (also known as \"Brazilian blastomycosis,\" \"South American... more...

Related Diseases for Paracoccidioidomycosis

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Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 271)
idRelated DiseaseScoreTop Affiliating Genes
1cryptococcosis30.1IFNG, IL10, IL4
2rheumatoid arthritis27.9CD40LG, CTLA4, IFNG, IL10, IL4, TNF
3blastomycosis24.7ALB, CD40LG, CTLA4, GLO1, IFNG, IL10
4punctate palmoplantar keratoderma type 210.8IL10, TNF
5multifocal lymphangioendotheliomatosis with thrombocytopenia10.8IL10, TNF
6alternating exotropia10.7IL10, TNF
7autoimmune polyglandular syndrome type 210.7CTLA4, TNF
8oropouche fever10.7CD40LG, IL10
9erdheim-chester disease10.7CD40LG, TNF
10androgen insensitivity syndrome, mild10.7CTLA4, TNF
11drug-induced mental disorder10.7IL10, TNF
12penicillin allergy10.7IL10, IL4
13sjogren's syndrome10.7CD40LG, TNF
14brucella melitensis brucellosis10.7CD40LG, TNF
15rhinoscleroma10.6CD40LG, TNF
16lateral displacement of eye10.6CD40LG, POMC
17superficial urinary bladder cancer10.6IL10, IL4
18posterior scleritis10.6CD40LG, POMC
19benign paroxysmal positional nystagmus10.6CTLA4, IL4
20autoimmune oophoritis10.6IFNG, TNF
21craniofacioskeletal syndrome10.6CD40LG, IL4
22non-distal monosomy 10q10.6IFNG, TNF
23graft-versus-host disease, protection against10.6IFNG, IL10
24ethmoid sinus squamous cell carcinoma10.6IFNG, TNF
25alpha chain disease10.6CD40LG, MYD88
26generalized atherosclerosis10.6CD40LG, MYD88
27beriberi10.5CD40LG, IFNG
28primary progressive freezing gait10.5IL10, IL4, TNF
29moderately severe hemophilia a10.5CTLA4, IL10, TNF
30kearns-sayre syndrome10.5IL10, IL4, TNF
31parasitic ichthyosporea infectious disease10.5IFNG, TNF
32achalasia10.5IL10, IL4, TNF
33progressive relapsing multiple sclerosis10.5CTLA4, IL10, TNF
34bacillary angiomatosis10.5CD40LG, IFNG
35multiple sclerosis 510.5TNF, TNFRSF1A
36goat milk allergy10.5IL10, IL4, TNF
37limbic encephalitis with ncmags antibodies10.5IFNG, IL4
38chronic demyelinizing neuropathy with igm monoclonal10.5IFNG, IL10
39methylmalonic acidemia10.5IL10, IL4, TNF
40kernicterus due to isoimmunization10.5CD40LG, IL10, TNF
41telangiectasis10.5TNF, TNFRSF1A
42kohler's disease10.5IL10, IL4, TNF
43constant exophthalmos10.5CD40LG, IL10, TNF
44lateral sclerosis10.5CD40LG, IL10, TNF
45mobitz type ii atrioventricular block10.5CD40LG, IL4
46dysgammaglobulinemia10.5CD40LG, IL10, IL4
47wrinkles10.5CD40LG, MYD88
48gingival overgrowth10.5IL10, IL4, TNF
49benign dermal neurilemmoma10.4CD40LG, IL10, IL4
50tinea manuum10.4ALB, TNF

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to paracoccidioidomycosis

Symptoms for Paracoccidioidomycosis

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Drugs & Therapeutics for Paracoccidioidomycosis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Paracoccidioidomycosis

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: paracoccidioidomycosis

Genetic Tests for Paracoccidioidomycosis

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Anatomical Context for Paracoccidioidomycosis

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MalaCards organs/tissues related to Paracoccidioidomycosis:

33
Bone, Lung, Skin, Lymph node, Liver, T cells, Thyroid

FMA organs/tissues related to Paracoccidioidomycosis:

16
Mucosa, Lymph nodes, Bone, Skin or

Animal Models for Paracoccidioidomycosis or affiliated genes

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MGI Mouse Phenotypes related to Paracoccidioidomycosis:

38 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5IFNG, IL10, IL4, MYD88, TNF, TNFRSF1A
2MP:00053888.3CTLA4, IFNG, IL10, IL4, MYD88, TNF
3MP:00053898.2CD40LG, IFNG, IL10, IL4, MYD88, TNF
4MP:00030128.2IFNG, IL10, IL4, MYD88, POMC, TNF
5MP:00107718.0CD40LG, CTLA4, IFNG, IL10, IL4, POMC
6MP:00020068.0ALB, IFNG, IL10, MYD88, POMC, TNF
7MP:00053707.8ALB, CTLA4, IFNG, IL10, IL4, POMC
8MP:00036317.8CD40LG, IFNG, IL10, IL4, MYD88, POMC
9MP:00053677.7ALB, CD40LG, IFNG, IL4, MYD88, POMC
10MP:00053817.6ALB, CTLA4, IFNG, IL10, IL4, MYD88
11MP:00053907.6CD40LG, CTLA4, IFNG, IL10, IL4, MYD88
12MP:00053857.5CD40LG, CTLA4, IFNG, IL10, MYD88, POMC
13MP:00053847.1ALB, CD40LG, IFNG, IL10, IL4, MYD88
14MP:00053797.0ALB, CD40LG, CTLA4, IFNG, IL10, IL4
15MP:00053876.3CD40LG, CTLA4, IFNG, IL10, IL4, MYD88
16MP:00053976.1CD40LG, CTLA4, IFNG, IL10, IL4, MYD88
17MP:00107685.9ALB, CD40LG, CTLA4, IFNG, IL10, IL4
18MP:00053765.4ALB, CD40LG, CTLA4, GLO1, IFNG, IL10

Publications for Paracoccidioidomycosis

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Articles related to Paracoccidioidomycosis:

(show top 50)    (show all 564)
idTitleAuthorsYear
1
Pulmonary paracoccidioidomycosis showing reversed halo sign with nodular/coarse contour. (26929466)
2016
2
PARACOCCIDIOIDOMYCOSIS IN A RENAL TRANSPLANT RECIPIENT. (26910451)
2016
3
Serum antibody levels correlate with oral fungal cell numbers and influence the patients' response to chronic paracoccidioidomycosis. (25851750)
2015
4
PARACOCCIDIOIDOMYCOSIS TREATMENT. (26465367)
2015
5
M2 macrophages and inflammatory cells in oral lesions of chronic paracoccidioidomycosis. (26041558)
2015
6
Prevalence of paracoccidioidomycosis infection by intradermal reaction in rural areas in Alfenas, Minas Gerais, Brazil. (25076426)
2014
7
The role of leukotriene B4 in early stages of experimental paracoccidioidomycosis induced in phenotypically selected mouse strains. (23534453)
2013
8
Paracoccidioidomycosis simulating a soft tissue tumor. (24261836)
2013
9
The pivotal role of 5-lipoxygenase-derived LTB4 in controlling pulmonary paracoccidioidomycosis. (23991239)
2013
10
Chronic paracoccidioidomycosis of the intestine as single organ involvement points to an alternative pathogenesis of the mycosis. (23982286)
2013
11
The left lung is preferentially targeted during experimental paracoccidioidomycosis in C57BL/6 mice. (24141611)
2013
12
Serological survey of paracoccidioidomycosis in cats. (23912468)
2013
13
Regulatory T cells in cutaneous lesions of patients withA Paracoccidioidomycosis. (24107311)
2013
14
Osteomyelitis and pyoarthritis resulting from local paracoccidioidomycosis in an immunocompetent patient: a case report. (23043817)
2012
15
Synchronous oral paracoccidioidomycosis and esophageal carcinoma. (22371017)
2012
16
Paracoccidioidomycosis: high-resolution computed tomography-pathologic correlation. (19608361)
2011
17
Seropositive antiaquaporin-4 antibody associated with multisegmental myelitis in a patient with paracoccidioidomycosis. (21803375)
2011
18
Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis. (22046142)
2011
19
Analysis of invariant natural killer T cells in human paracoccidioidomycosis. (21805204)
2011
20
Gastrointestinal paracoccidioidomycosis: an overview. (20975575)
2011
21
Paracoccidioidomycosis in a dog: case report of generalized lymphadenomegaly. (21424604)
2011
22
Altered ex vivo expression of caspase 8, caspase 9, and Bcl-2 is associated with T-cell hyporeactivity in patients with paracoccidioidomycosis. (19386797)
2009
23
Oral paracoccidioidomycosis and pulmonary tuberculosis co-infection: relevance of oral biopsy in establishing the diagnosis and therapeutic approach. (18650110)
2009
24
Inducible nitric oxide synthase-deficient mice show exacerbated inflammatory process and high production of both Th1 and Th2 cytokines during paracoccidioidomycosis. (19063988)
2009
25
Hypercalcemia in a patient with disseminated paracoccidioidomycosis: a case report. (18691418)
2008
26
Experimental paracoccidioidomycosis: alternative therapy with ajoene, compound from Allium sativum, associated with sulfamethoxazole/trimethoprim. (18324489)
2008
27
Use of recombinant gp43 isoforms expressed in Pichia pastoris for diagnosis of paracoccidioidomycosis. (18235042)
2008
28
Characterization of inflammatory cells in oral paracoccidioidomycosis. (17577332)
2007
29
Neutrophil role in pulmonary paracoccidioidomycosis depends on the resistance pattern of hosts. (16603588)
2006
30
Infiltrative myelopathy by paracoccidioidomycosis. A review and report of nine cases with emphasis on bone marrow morphology. (16487359)
2006
31
The role of interleukin-10 in the differential expression of interleukin-12p70 and its beta2 receptor on patients with active or treated paracoccidioidomycosis and healthy infected subjects. (15596413)
2005
32
Absence of interleukin-4 determines less severe pulmonary paracoccidioidomycosis associated with impaired Th2 response. (15039362)
2004
33
Paracoccidioidomycosis in a woman with idiopathic hirsutism. (15487322)
2004
34
Paracoccidioidomycosis associated with human immunodeficiency virus infection. Report of 10 cases. (12964719)
2003
35
Paracoccidioidomycosis of the mouth: an emerging deep mycosis. (14530306)
2003
36
Unique adrenal gland imaging features in Addison's disease caused by paracoccidioidomycosis. (14573459)
2003
37
Dendritic cells and pattern of cytokines in paracoccidioidomycosis skin lesions. (12652191)
2003
38
Paracoccidioidomycosis mortality in Brazil (1980-1995). (12244377)
2002
39
Anti-gp43 antibodies in the cerebrospinal fluid of patients with central nervous system involvement by paracoccidioidomycosis. (12472279)
2002
40
Cytokines and lymphocyte proliferation in juvenile and adult forms of paracoccidioidomycosis: comparison with infected and non-infected controls. (11880044)
2002
41
Paracoccidioidomycosis: report of 2 cases mimicking squamous cell carcinoma. (12424456)
2002
42
Levels of specific antigen (gp43), specific antibodies, and antigen-antibody complexes in saliva and serum of paracoccidioidomycosis patients. (12054053)
2001
43
Canine paracoccidioidomycosis: a seroepidemiologic study. (11446531)
2001
44
Fibrotic sequelae in pulmonary paracoccidioidomycosis: histopathological aspects in BALB/c mice infected with viable and non-viable paracoccidioides brasiliensis propagules. (10810319)
2000
45
DNA-based vaccination against murine paracoccidioidomycosis using the gp43 gene from paracoccidioides brasiliensis. (10825609)
2000
46
Central nervous system paracoccidioidomycosis. Report of a case successfully treated with itraconazol. (10968887)
2000
47
Experimental paracoccidioidomycosis of the Syrian hamster: fungicidal activity and production of inflammatory cytokines by macrophages. (10746228)
2000
48
Endemic regions of paracoccidioidomycosis in Brazil: a clinical and epidemiologic study of 584 cases in the southeast region. (10497977)
1999
49
Hypercalcaemia and paracoccidioidomycosis. (9764330)
1998
50
Aspergillus fumigatus fungus ball in a patient with healed paracoccidioidomycosis. (9431402)
1997

Variations for Paracoccidioidomycosis

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Expression for genes affiliated with Paracoccidioidomycosis

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Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for genes affiliated with Paracoccidioidomycosis

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Pathways related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show all 39)
idSuper pathwaysScoreTop Affiliating Genes
19.7TNF, TNFRSF1A
29.5CD40LG, IL10, IL4
39.5IL10, MYD88, TNF
49.5IFNG, IL10, TNF
59.5IFNG, IL10, TNF
6
Show member pathways
9.5IFNG, IL10, TNF
79.4CTLA4, IFNG, TNF
89.4IFNG, IL10, IL4
99.4IFNG, IL10, IL4
109.4IFNG, IL4, TNF
119.3IFNG, IL4, POMC
12
Show member pathways
9.3CD40LG, TNF, TNFRSF1A
139.3POMC, TNF, TNFRSF1A
149.2MYD88, TNF, TNFRSF1A
159.2IFNG, TNF, TNFRSF1A
16
Show member pathways
9.2IFNG, TNF, TNFRSF1A
179.1IFNG, IL10, IL4, TNF
189.1IFNG, IL10, IL4, TNF
199.1IFNG, IL10, IL4, TNF
20
Show member pathways
9.1IFNG, IL10, IL4, TNF
21
Show member pathways
9.1ALB, IFNG, TNF
229.0IFNG, IL10, MYD88, TNF
23
Show member pathways
9.0IFNG, IL4, MYD88, TNF
249.0CD40LG, CTLA4, IL10, IL4, TNF
25
Show member pathways
8.9IFNG, IL10, TNF, TNFRSF1A
26
Show member pathways
8.9CD40LG, MYD88, TNF, TNFRSF1A
278.9CD40LG, MYD88, TNF, TNFRSF1A
28
Show member pathways
8.9CD40LG, MYD88, TNF, TNFRSF1A
29
Show member pathways
8.9CD40LG, IFNG, TNF, TNFRSF1A
308.8CD40LG, IFNG, IL4, TNFRSF1A
31
Show member pathways
8.8CD40LG, CTLA4, IFNG, IL4, TNF
328.7CD40LG, IFNG, IL10, MYD88, TNF
33
Show member pathways
8.5IFNG, IL10, MYD88, TNF, TNFRSF1A
348.5IFNG, IL10, MYD88, TNF, TNFRSF1A
35
Show member pathways
8.5CD40LG, CTLA4, IFNG, IL10, IL4, TNF
36
Show member pathways
8.5IFNG, IL4, MYD88, TNF, TNFRSF1A
37
Show member pathways
8.3CD40LG, IL10, IL4, MYD88, TNF, TNFRSF1A
38
Show member pathways
8.0CD40LG, CTLA4, IFNG, IL10, IL4, TNF
39
Show member pathways
7.9CD40LG, IFNG, IL10, IL4, MYD88, TNF

GO Terms for genes affiliated with Paracoccidioidomycosis

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Biological processes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:003280010.6IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:000274010.6IL10, TNF
3positive regulation of mononuclear cell migrationGO:007167710.5IL4, TNF
4type 2 immune responseGO:004209210.5IL10, IL4
5regulation of immunoglobulin secretionGO:005102310.5CD40LG, TNF
6negative regulation of interleukin-6 productionGO:003271510.4IL10, TNF
7positive regulation of calcidiol 1-monooxygenase activityGO:006055910.4IFNG, TNF
8positive regulation of membrane protein ectodomain proteolysisGO:005104410.4IFNG, TNF
9negative regulation of endothelial cell apoptotic processGO:200035210.4IL10, IL4
10negative regulation of tumor necrosis factor productionGO:003272010.4IL10, POMC
11negative regulation of nitric oxide biosynthetic processGO:004501910.4IL10, IL4
12positive regulation of interleukin-10 productionGO:003273310.3CD40LG, IL4
13positive regulation of interleukin-23 productionGO:003274710.3IFNG, MYD88
14regulation of establishment of endothelial barrierGO:190314010.3TNF, TNFRSF1A
15death-inducing signaling complex assemblyGO:007155010.3TNF, TNFRSF1A
16positive regulation of T cell proliferationGO:004210210.3IFNG, IL4
17protein import into nucleus, translocationGO:000006010.2IFNG, TNF
18positive regulation of ceramide biosynthetic processGO:200030410.2TNF, TNFRSF1A
19positive regulation of isotype switching to IgG isotypesGO:004830410.2IFNG, IL4
20B cell differentiationGO:003018310.1CD40LG, IL10, IL4
21positive regulation of osteoclast differentiationGO:004567210.1IFNG, TNF
22defense response to protozoanGO:004283210.1IFNG, IL10, IL4
23positive regulation of sequence-specific DNA binding transcription factor activityGO:005109110.1IL10, IL4, TNF
24establishment of protein localization to plasma membraneGO:009000210.0TNF, TNFRSF1A
25extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.9TNF, TNFRSF1A
26positive regulation of MHC class II biosynthetic processGO:00453489.9IFNG, IL10, IL4
27regulation of immune responseGO:00507769.8CD40LG, IFNG, IL4
28response to virusGO:00096159.8IFNG, MYD88, TNF
29positive regulation of NF-kappaB transcription factor activityGO:00510929.7CD40LG, MYD88, TNF
30positive regulation of chemokine biosynthetic processGO:00450809.7IFNG, IL4, MYD88, TNF
31negative regulation of growth of symbiont in hostGO:00441309.6IFNG, IL10, MYD88, TNF
32cytokine-mediated signaling pathwayGO:00192219.6IFNG, MYD88, TNFRSF1A
33positive regulation of transcription, DNA-templatedGO:00458939.5IFNG, IL10, IL4, TNF
34cell surface receptor signaling pathwayGO:00071669.5IFNG, TNF, TNFRSF1A
35defense response to bacteriumGO:00427429.5IFNG, IL10, TNF
36regulation of cell proliferationGO:00421279.2MYD88, TNF, TNFRSF1A
37immune responseGO:00069559.2IFNG, IL10, IL4, TNF
38inflammatory responseGO:00069549.2IL10, MYD88, TNF, TNFRSF1A
39response to organic substanceGO:00100339.0ALB, IL10, TNF
40negative regulation of apoptotic processGO:00430668.1ALB, CD40LG, GLO1, IL10, IL4, MYD88

Sources for Paracoccidioidomycosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet