PCM
MCID: PRC002
MIFTS: 67

Paracoccidioidomycosis (PCM) malady

Rare diseases, Infectious diseases, Immune diseases, Bone diseases, Skin diseases categories

Summaries for Paracoccidioidomycosis

About this section


Disease Ontology:9 A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in paracoccidioides brasiliensis.

MalaCards based summary: Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to hepatitis and vasculitis. An important gene associated with Paracoccidioidomycosis is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Immune response Bacterial infections in normal airways and TNF signaling pathway. The drugs ketoconazole and itraconazole and the compounds glatiramer acetate and p 277 have been mentioned in the context of this disorder. Affiliated tissues include mucosa, lymph nodes and bone, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Wikipedia:64 Paracoccidioidomycosis (also known as \"Brazilian blastomycosis,\" \"South American... more...

Aliases & Classifications for Paracoccidioidomycosis

About this section
Sources:
9Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 48Orphanet, 61UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 28ICD9CM, 35MESH via Orphanet, 27ICD10 via Orphanet, 62UMLS via Orphanet, 26ICD10
See all sources

Paracoccidioidomycosis, Aliases & Descriptions:

Name: Paracoccidioidomycosis 9 42 44 48 61
Mucocutaneous-Lymphangitic Paracoccidioidomycosis 9 61
Lutz-Splendore-Almeida Disease 42 61
Paracoccidioidal Granuloma 42 61
Paracoccidioidal Mycosis 9 61
Paracoccidioidomycosis, Unspecified 9
Blastomycosis, South American 61
 
South American Blastomycosis 42
Protein-Energy Malnutrition 61
Paracoccidioidomycosis Nos 9
Lobo's Disease 61
Lobo Disease 42
Pcm 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
paracoccidioidomycosis:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

Disease Ontology9 DOID:12662
NCIt39 C34891
MeSH34 D010229
ICD9CM28 116.1
MESH via Orphanet35 D010229
ICD10 via Orphanet27 B41.0, B41.7, B41.8 B41.9, more
UMLS via Orphanet62 C0030409
ICD1026 B41, B41.9

Related Diseases for Paracoccidioidomycosis

About this section

Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.3CXCL10, TNFRSF1A
2vasculitis30.2HSPD1, CTLA4
3periodontitis30.1IL10, HSPD1
4hepatitis c29.8CXCL10, HSPD1, IL10
5septic shock29.8IL10, TNFRSF1A
6tuberculosis29.6TNFRSF1A, TPI1, CXCL10, HSPD1, IL10
7lung cancer29.4CTLA4, TPI1, HSPD1, TNFRSF1A
8arthritis29.1CTLA4, CXCL10, HSPD1, TNFRSF1A, IL10
9rheumatoid arthritis29.0HSPD1, IL10, CXCL10, TNFRSF1A, CTLA4
10vulvovaginitis10.4HSPD1
11meningitis10.4CXCL10
12trachoma10.4HSPD1
13blastomycosis10.4
14histoplasmosis10.4
15arthropathy10.2CTLA4, CXCL10
16behcet's disease10.2CTLA4, HSPD1
17autoimmune hepatitis10.2HSPD1, CTLA4
18connective tissue disease10.2IL10, CTLA4
19dermatitis10.2CXCL10, CTLA4
20primary biliary cirrhosis10.2CTLA4, HSPD1
21myasthenia gravis10.2IL10, CTLA4
22pulmonary tuberculosis10.2
23acquired immunodeficiency syndrome10.2
24lobomycosis10.2
25cervicitis10.2
26laryngitis10.2
27prostatitis10.2
28lepromatous leprosy10.2IL10, HSPD1
29atopy10.1IL10, CTLA4
30plasmodium falciparum malaria10.1TPI1, IL10
31graves' disease10.1CTLA4, CXCL10
32stenotrophomonas maltophilia10.1
33allergic rhinitis10.1CTLA4, IL10
34hypercalcemia10.1
35esophagitis10.1
36gingivitis10.1
37osteomyelitis10.1
38sarcoma10.1
39mycetoma10.1
40tetanus10.1IL10, HSPD1
41periodontal disease10.1CXCL10, HSPD1, CTLA4
42ankylosing spondylitis10.0TNFRSF1A, HSPD1
43type 1 diabetes mellitus10.0CTLA4, CXCL10, HSPD1
44hepatitis b10.0CXCL10, IL10, CTLA4
45common variable immunodeficiency10.0IL10, TNFRSF1A
46colitis10.0CXCL10, IL10, CTLA4
47neutropenia10.0CXCL10, TNFRSF1A
48leishmaniasis10.0TNFRSF1A, IL10
49atopic dermatitis10.0CXCL10, IL10, CTLA4
50ulcerative colitis10.0CTLA4, IL10, CXCL10

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to paracoccidioidomycosis

Symptoms for Paracoccidioidomycosis

About this section

Drugs & Therapeutics for Paracoccidioidomycosis

About this section

Drug clinical trials:

Search ClinicalTrials for Paracoccidioidomycosis

Search NIH Clinical Center for Paracoccidioidomycosis

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Paracoccidioidomycosis

About this section

Anatomical Context for Paracoccidioidomycosis

About this section

MalaCards organs/tissues related to Paracoccidioidomycosis:

32
Bone, Lung, Skin, Lymph node, T cells, Testes, Monocytes, Bone marrow, Prostate, Neutrophil, Adrenal gland, Spleen, Thymus, Brain, Spinal cord, Colon, Myeloid, B cells, Tongue

FMA organs/tissues related to Paracoccidioidomycosis:

15
Mucosa, Lymph nodes, Bone, Skin or

Animal Models for Paracoccidioidomycosis or affiliated genes

About this section

MGI Mouse Phenotypes related to Paracoccidioidomycosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2CTLA4, IL10, CXCL10, TNFRSF1A
2MP:00053977.6TNFRSF1A, TPI1, CXCL10, IL10, CTLA4
3MP:00053877.5TNFRSF1A, TPI1, CXCL10, IL10, CTLA4
4MP:00053767.3TNFRSF1A, TPI1, CXCL10, IL10, CTLA4
5MP:00107687.2CTLA4, IL10, CXCL10, TPI1, HSPD1, TNFRSF1A

Publications for Paracoccidioidomycosis

About this section

Articles related to Paracoccidioidomycosis:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Prevalence of paracoccidioidomycosis infection by intradermal reaction in rural areas in Alfenas, Minas Gerais, Brazil. (25076426)
2014
2
The role of leukotriene B4 in early stages of experimental paracoccidioidomycosis induced in phenotypically selected mouse strains. (23534453)
2013
3
Paracoccidioidomycosis simulating a soft tissue tumor. (24261836)
2013
4
The pivotal role of 5-lipoxygenase-derived LTB4 in controlling pulmonary paracoccidioidomycosis. (23991239)
2013
5
Chronic paracoccidioidomycosis of the intestine as single organ involvement points to an alternative pathogenesis of the mycosis. (23982286)
2013
6
The left lung is preferentially targeted during experimental paracoccidioidomycosis in C57BL/6 mice. (24141611)
2013
7
Serological survey of paracoccidioidomycosis in cats. (23912468)
2013
8
Regulatory T cells in cutaneous lesions of patients withA Paracoccidioidomycosis. (24107311)
2013
9
Osteomyelitis and pyoarthritis resulting from local paracoccidioidomycosis in an immunocompetent patient: a case report. (23043817)
2012
10
Synchronous oral paracoccidioidomycosis and esophageal carcinoma. (22371017)
2012
11
Paracoccidioidomycosis: high-resolution computed tomography-pathologic correlation. (19608361)
2011
12
Seropositive antiaquaporin-4 antibody associated with multisegmental myelitis in a patient with paracoccidioidomycosis. (21803375)
2011
13
Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis. (22046142)
2011
14
Analysis of invariant natural killer T cells in human paracoccidioidomycosis. (21805204)
2011
15
Gastrointestinal paracoccidioidomycosis: an overview. (20975575)
2011
16
Paracoccidioidomycosis in a dog: case report of generalized lymphadenomegaly. (21424604)
2011
17
Histoplasmosis and paracoccidioidomycosis in a non-endemic area: a review of cases and diagnosis. (21199139)
2011
18
Altered ex vivo expression of caspase 8, caspase 9, and Bcl-2 is associated with T-cell hyporeactivity in patients with paracoccidioidomycosis. (19386797)
2009
19
Oral paracoccidioidomycosis and pulmonary tuberculosis co-infection: relevance of oral biopsy in establishing the diagnosis and therapeutic approach. (18650110)
2009
20
Inducible nitric oxide synthase-deficient mice show exacerbated inflammatory process and high production of both Th1 and Th2 cytokines during paracoccidioidomycosis. (19063988)
2009
21
Hypercalcemia in a patient with disseminated paracoccidioidomycosis: a case report. (18691418)
2008
22
Experimental paracoccidioidomycosis: alternative therapy with ajoene, compound from Allium sativum, associated with sulfamethoxazole/trimethoprim. (18324489)
2008
23
Use of recombinant gp43 isoforms expressed in Pichia pastoris for diagnosis of paracoccidioidomycosis. (18235042)
2008
24
Characterization of inflammatory cells in oral paracoccidioidomycosis. (17577332)
2007
25
An open-label comparative pilot study of oral voriconazole and itraconazole for long-term treatment of paracoccidioidomycosis. (17990229)
2007
26
Neutrophil role in pulmonary paracoccidioidomycosis depends on the resistance pattern of hosts. (16603588)
2006
27
Infiltrative myelopathy by paracoccidioidomycosis. A review and report of nine cases with emphasis on bone marrow morphology. (16487359)
2006
28
The role of interleukin-10 in the differential expression of interleukin-12p70 and its beta2 receptor on patients with active or treated paracoccidioidomycosis and healthy infected subjects. (15596413)
2005
29
Absence of interleukin-4 determines less severe pulmonary paracoccidioidomycosis associated with impaired Th2 response. (15039362)
2004
30
Paracoccidioidomycosis in a woman with idiopathic hirsutism. (15487322)
2004
31
Paracoccidioidomycosis associated with human immunodeficiency virus infection. Report of 10 cases. (12964719)
2003
32
Paracoccidioidomycosis of the mouth: an emerging deep mycosis. (14530306)
2003
33
Unique adrenal gland imaging features in Addison's disease caused by paracoccidioidomycosis. (14573459)
2003
34
Dendritic cells and pattern of cytokines in paracoccidioidomycosis skin lesions. (12652191)
2003
35
Paracoccidioidomycosis mortality in Brazil (1980-1995). (12244377)
2002
36
Anti-gp43 antibodies in the cerebrospinal fluid of patients with central nervous system involvement by paracoccidioidomycosis. (12472279)
2002
37
Cytokines and lymphocyte proliferation in juvenile and adult forms of paracoccidioidomycosis: comparison with infected and non-infected controls. (11880044)
2002
38
Paracoccidioidomycosis: report of 2 cases mimicking squamous cell carcinoma. (12424456)
2002
39
Levels of specific antigen (gp43), specific antibodies, and antigen-antibody complexes in saliva and serum of paracoccidioidomycosis patients. (12054053)
2001
40
Canine paracoccidioidomycosis: a seroepidemiologic study. (11446531)
2001
41
Fibrotic sequelae in pulmonary paracoccidioidomycosis: histopathological aspects in BALB/c mice infected with viable and non-viable paracoccidioides brasiliensis propagules. (10810319)
2000
42
DNA-based vaccination against murine paracoccidioidomycosis using the gp43 gene from paracoccidioides brasiliensis. (10825609)
2000
43
Central nervous system paracoccidioidomycosis. Report of a case successfully treated with itraconazol. (10968887)
2000
44
Experimental paracoccidioidomycosis of the Syrian hamster: fungicidal activity and production of inflammatory cytokines by macrophages. (10746228)
2000
45
Endemic regions of paracoccidioidomycosis in Brazil: a clinical and epidemiologic study of 584 cases in the southeast region. (10497977)
1999
46
Hypercalcaemia and paracoccidioidomycosis. (9764330)
1998
47
Aspergillus fumigatus fungus ball in a patient with healed paracoccidioidomycosis. (9431402)
1997
48
Paracoccidioidomycosis in a boy infected with HIV. (9470418)
1997
49
The role of somatic structure of the fungus Paracoccidioides brasiliensis upon B cell activation in experimental paracoccidioidomycosis. (7648716)
1995
50
Paracoccidioidomycosis and its etiologic agent Paracoccidioides brasiliensis. (8509955)
1993

Variations for Paracoccidioidomycosis

About this section

Expression for genes affiliated with Paracoccidioidomycosis

About this section
Expression patterns in normal tissues for genes affiliated with Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for genes affiliated with Paracoccidioidomycosis

About this section

Pathways related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
9.2CXCL10, TNFRSF1A
29.2CXCL10, TNFRSF1A
3
Show member pathways
9.0IL10, TNFRSF1A
4
Show member pathways
8.6TNFRSF1A, CXCL10, IL10
5
Show member pathways
8.6TNFRSF1A, CXCL10, IL10
6
Show member pathways
8.6TNFRSF1A, CXCL10, IL10
7
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.6TNFRSF1A, CXCL10, IL10
88.5IL10, HSPD1, TNFRSF1A
9
Show member pathways
8.1CTLA4, IL10, HSPD1, TNFRSF1A

Compounds for genes affiliated with Paracoccidioidomycosis

About this section

Compounds related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1glatiramer acetate44 1210.8IL10, CTLA4
2p 277449.8HSPD1, IL10
3bifidobacterium449.7IL10, HSPD1
4indoleamine449.7CTLA4, IL10
5toxin-1449.7IL10, HSPD1
6tuberculin449.7HSPD1, IL10
7con a449.6IL10, CTLA4
8groalpha449.6CXCL10, IL10
9isocitrate449.6TPI1, HSPD1
10polymyxin b449.6HSPD1, IL10
11iodine44 2510.5CTLA4, TNFRSF1A
12polyinosinic-polycytidylic acid449.5IL10, CXCL10
13il 10449.4IL10, CTLA4, CXCL10
14allergens449.4IL10, CTLA4, CXCL10
15blys449.4IL10, TNFRSF1A
162,5-oligoadenylate449.4CXCL10, IL10
17tacrolimus44 50 1211.4CXCL10, CTLA4, IL10
18adalimumab44 50 1211.3TNFRSF1A, IL10
19okt3449.3IL10, TNFRSF1A
20vitamin d449.2IL10, CXCL10, CTLA4
21manganese superoxide449.0HSPD1, TPI1, TNFRSF1A
22thalidomide44 50 60 1212.0TNFRSF1A, IL10, CTLA4
23tgf beta1449.0TNFRSF1A, CTLA4, IL10
24ionomycin449.0CTLA4, TNFRSF1A, IL10
25neopterin449.0CXCL10, IL10, TNFRSF1A
26chloroquine44 3 50 29 1213.0CXCL10, TNFRSF1A, IL10
27methotrexate50 44 1211.0CTLA4, TNFRSF1A, IL10
28etanercept44 50 1210.7IL10, TNFRSF1A
29phosphatidylinositol448.6CXCL10, HSPD1, TNFRSF1A, CTLA4
30paraffin448.6TNFRSF1A, HSPD1, IL10
31infliximab44 50 1210.6CTLA4, IL10, CXCL10, TNFRSF1A
32alanine448.6TNFRSF1A, CTLA4, CXCL10, HSPD1
33superoxide44 259.6HSPD1, TNFRSF1A, TPI1
34estrogen448.6CTLA4, HSPD1, TNFRSF1A, CXCL10
35creatinine448.6TPI1, HSPD1, TNFRSF1A, CXCL10
36glutamate448.6TPI1, HSPD1, CTLA4, TNFRSF1A
37cyclosporin a44 29 6010.5HSPD1, IL10, CTLA4, TNFRSF1A
38cysteine448.5CTLA4, TPI1, HSPD1, TNFRSF1A
39endotoxin448.5IL10, TNFRSF1A, CXCL10, HSPD1
40pge2448.5TNFRSF1A, IL10, CXCL10
41atp44 299.5CXCL10, TNFRSF1A, HSPD1, TPI1
42cycloheximide448.5HSPD1, CXCL10, TNFRSF1A, IL10
43vegf448.4TNFRSF1A, CXCL10, HSPD1, IL10
44aspartate448.4IL10, TPI1, HSPD1, TNFRSF1A
45cholesterol44 29 25 1211.2CXCL10, TNFRSF1A, HSPD1, TPI1, CTLA4
46glucose448.2CTLA4, HSPD1, TNFRSF1A, TPI1, CXCL10
47lipid448.2TNFRSF1A, HSPD1, CXCL10, TPI1, CTLA4
48tyrosine448.1HSPD1, CTLA4, CXCL10, TPI1, TNFRSF1A
49rantes448.1IL10, HSPD1, CTLA4, CXCL10, TNFRSF1A
50dexamethasone44 50 29 1211.1CTLA4, IL10, TNFRSF1A, CXCL10, HSPD1

GO Terms for genes affiliated with Paracoccidioidomycosis

About this section

Cellular components related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.5IL10, CXCL10, TPI1, HSPD1, TNFRSF1A

Biological processes related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of B cell proliferationGO:0308899.7CTLA4, IL10
2negative regulation of T cell proliferationGO:0421309.5IL10, CTLA4
3B cell proliferationGO:0421009.4IL10, HSPD1
4cellular response to estradiol stimulusGO:0713929.2IL10, TNFRSF1A
5negative regulation of interleukin-6 productionGO:0327159.2IL10, TNFRSF1A
6response to lipopolysaccharideGO:0324969.2CXCL10, TNFRSF1A
7defense response to bacteriumGO:0427428.9TNFRSF1A, IL10
8inflammatory responseGO:0069548.7TNFRSF1A, CXCL10, IL10
9negative regulation of apoptotic processGO:0430668.5IL10, HSPD1, TNFRSF1A
10positive regulation of transcription from RNA polymerase II promoterGO:0459448.3IL10, CXCL10, TNFRSF1A

Products for genes affiliated with Paracoccidioidomycosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Paracoccidioidomycosis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet