MCID: PRC002
MIFTS: 52

Paracoccidioidomycosis

Categories: Rare diseases, Infectious diseases, Immune diseases

Aliases & Classifications for Paracoccidioidomycosis

MalaCards integrated aliases for Paracoccidioidomycosis:

Name: Paracoccidioidomycosis 12 50 56 52 42 14 69
Mucocutaneous-Lymphangitic Paracoccidioidomycosis 12
Paracoccidioidomycosis, Unspecified 12
Lutz-Splendore-Almeida Disease 50
South American Blastomycosis 50
Paracoccidioidomycosis Nos 12
Paracoccidioidal Granuloma 50
Paracoccidioidal Mycosis 12
Lobo Disease 50
Lobomycosis 69
Pcm 50

Characteristics:

Orphanet epidemiological data:

56
paracoccidioidomycosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12662
ICD10 33 B41 B41.9
ICD9CM 35 116.1
MeSH 42 D010229
NCIt 47 C34891
Orphanet 56 ORPHA73260
MESH via Orphanet 43 D010229
UMLS via Orphanet 70 C0030409
ICD10 via Orphanet 34 B41.0 B41.7 B41.8 more
UMLS 69 C0030409

Summaries for Paracoccidioidomycosis

Disease Ontology : 12 A primary systemic mycosis that results_in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in Paracoccidioides brasiliensis.

MalaCards based summary : Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to pulmonary tuberculosis and hypereosinophilic syndrome. An important gene associated with Paracoccidioidomycosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include lung, bone and skin, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Paracoccidioidomycosis (PCM) (also known as \"Brazilian blastomycosis,\" \"South American... more...

Related Diseases for Paracoccidioidomycosis

Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 367)
id Related Disease Score Top Affiliating Genes
1 pulmonary tuberculosis 30.4 CXCL10 IFNG TNF
2 hypereosinophilic syndrome 29.4 IFNG IL5
3 myelitis 28.4 IFNG IL10 IL2 IL6
4 lymphoma 26.5 CTLA4 IFNG IL10 IL2 IL4 IL5
5 systemic lupus erythematosus 26.5 CD86 CTLA4 IFNG IL10 IL2 IL4
6 rheumatoid arthritis 25.0 CD86 CTLA4 IFNG IL10 IL2 IL4
7 pure autonomic failure 10.9 IL10 TNF
8 multiple familial trichoepithelioma 10.8 IL10 TNF
9 type 1 papillary adenoma of the kidney 10.8 IL10 TNF
10 sternal cleft 10.8 IFNG TNF
11 endosalpingiosis 10.8 IL10 TNF
12 myoclonic astatic epilepsy 10.7 IFNG IL4
13 mosaic trisomy 1 10.7 IFNG TNF
14 diabetic angiopathy 10.7 IL10 IL4
15 autoimmune retinopathy 10.7 CTLA4 TNF
16 dumping syndrome 10.7 IFNG IL10
17 primary systemic mycosis 10.7 IFNG TNF
18 gastroschisis 10.7 IFNG IL5
19 idiopathic dilatation of the pulmonary artery 10.7 IL10 TNF
20 deafness, autosomal recessive 22 10.7 IL10 IL4
21 neutrophil-specific granule deficiency 10.6 IL10 TLR2
22 nonspecific interstitial pneumonia 10.6 IL10 IL5
23 moderately severe hemophilia b 10.6 CTLA4 IL10 TNF
24 senile reticular retinal degeneration 10.6 IFNG IL10 TNF
25 acute ackee fruit intoxication 10.6 IL10 IL4 TNF
26 basidiobolomycosis 10.6 IL10 IL4 TNF
27 lagophthalmos 10.6 IL10 IL4 TNF
28 goat milk allergy 10.6 IFNG IL4
29 liver leiomyoma 10.6 IL10 IL4 TNF
30 combined cellular and humoral immune defects with granulomas 10.6 CTLA4 IFNG IL10
31 eye accommodation disease 10.5 IFNG IL10 IL4
32 thelaziasis 10.5 IFNG IL10 IL4
33 distal monosomy 7q36 10.5 CXCL10 IFNG IL10
34 geniculate ganglionitis 10.5 IFNG IL10 TNF
35 crustacean allergy 10.5 IL10 IL5
36 marasmus 10.5 IL4 IL5
37 respiratory system disease 10.5 IFNG IL10 TNF
38 centronuclear myopathy 5 10.5 IFNG IL10 IL4
39 spondylocostal dysostosis 4 10.5 TLR4 TNF
40 congenital insensitivity to pain with hyperhidrosis 10.5 IL10 TLR4
41 low compliance bladder 10.5 TLR4 TNF
42 glioblastoma multiforme 10.5 IL10 IL5 TNF
43 acute vascular insufficiency of intestine 10.5 IFNG IL4 TNF
44 scirrhous adenocarcinoma 10.5 IL2 TNF
45 orbit alveolar rhabdomyosarcoma 10.5 IL4 IL5
46 hepatitis b 10.5 IFNG IL10 TNF
47 progressive relapsing multiple sclerosis 10.5 CXCL10 IL10 IL4
48 tarsal tunnel syndrome 10.5 IL10 TNF
49 urethral intrinsic sphincter deficiency 10.4 IL4 IL5 TNF
50 central sleep apnea 10.4 IFNG IL4 TNF

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to Paracoccidioidomycosis

Symptoms & Phenotypes for Paracoccidioidomycosis

MGI Mouse Phenotypes related to Paracoccidioidomycosis:

44 (show all 21)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.36 IL4 IL5 IL6 POMC TLR2 TLR4
2 homeostasis/metabolism MP:0005376 10.35 IL6 POMC TLR2 TLR4 TNF CD86
3 immune system MP:0005387 10.34 CD86 CTLA4 CXCL10 IFNG IL10 IL2
4 cellular MP:0005384 10.32 CD86 CXCL10 IFNG IL10 IL2 IL4
5 behavior/neurological MP:0005386 10.3 CD86 IFNG IL10 IL2 IL5 IL6
6 cardiovascular system MP:0005385 10.29 IL10 IL2 IL6 POMC TLR2 TLR4
7 digestive/alimentary MP:0005381 10.27 TNF CTLA4 IFNG IL10 IL2 IL4
8 endocrine/exocrine gland MP:0005379 10.27 CD86 CTLA4 IFNG IL10 IL2 IL4
9 growth/size/body region MP:0005378 10.26 IFNG IL10 IL2 IL4 IL5 IL6
10 liver/biliary system MP:0005370 10.24 CTLA4 IFNG IL10 IL2 IL4 IL5
11 mortality/aging MP:0010768 10.22 CTLA4 CXCL10 IFNG IL10 IL2 IL4
12 integument MP:0010771 10.16 IL10 IL4 IL6 POMC TLR2 TLR4
13 nervous system MP:0003631 10.1 CD86 CXCL10 IFNG IL10 IL4 IL6
14 neoplasm MP:0002006 10.09 IFNG IL10 IL2 IL5 IL6 POMC
15 muscle MP:0005369 10 CD86 IFNG IL10 IL6 TLR2 TLR4
16 reproductive system MP:0005389 9.86 IFNG IL10 IL2 IL4 IL5 IL6
17 no phenotypic analysis MP:0003012 9.85 IFNG IL10 IL2 IL4 POMC TNF
18 respiratory system MP:0005388 9.85 TNF CTLA4 IFNG IL10 IL2 IL4
19 renal/urinary system MP:0005367 9.8 IFNG IL4 IL6 POMC TLR2 TLR4
20 skeleton MP:0005390 9.56 CTLA4 IFNG IL10 IL4 IL6 TLR2
21 vision/eye MP:0005391 9.17 IFNG IL10 IL2 IL4 IL6 TLR4

Drugs & Therapeutics for Paracoccidioidomycosis

Search Clinical Trials , NIH Clinical Center for Paracoccidioidomycosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: paracoccidioidomycosis

Genetic Tests for Paracoccidioidomycosis

Anatomical Context for Paracoccidioidomycosis

MalaCards organs/tissues related to Paracoccidioidomycosis:

39
Lung, Bone, Skin, Lymph Node, T Cells, Testes, Monocytes

Publications for Paracoccidioidomycosis

Articles related to Paracoccidioidomycosis:

(show top 50) (show all 601)
id Title Authors Year
1
NOD-Like Receptor P3 Inflammasome Controls Protective Th1/Th17 Immunity against Pulmonary Paracoccidioidomycosis. ( 28740491 )
2017
2
Subtractive phage display selection for screening and identification of peptide sequences with potential use in serodiagnosis of paracoccidioidomycosis caused by Paracoccidioides brasiliensis. ( 28796894 )
2017
3
Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43A kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis. ( 28646277 )
2017
4
Paracoccidioidomycosis: Epidemiological and Clinical Aspects in 546 Cases Studied in the State of EspA-rito Santo, Brazil. ( 28749757 )
2017
5
Case report of myeloperoxidase deficiency associated with disseminated paracoccidioidomycosis and peritoneal tuberculosis. ( 28954085 )
2017
6
DNAhsp65 Vaccine as Therapy against Paracoccidioidomycosis. ( 28584985 )
2017
7
Acute Paracoccidioidomycosis in a 40-Year-Old Man: A Case Report and Literature Review. ( 28900882 )
2017
8
Paracoccidioidomycosis with sarcoid-like lesions:a diagnostic challenge. ( 28562770 )
2017
9
Th1-Inducing Agents in Prophylaxis and Therapy for Paracoccidioidomycosis. ( 28584990 )
2017
10
Therapeutic treatment with scFv-PLGA nanoparticles decreases pulmonary fungal load in a murine model of paracoccidioidomycosis. ( 28951317 )
2017
11
Brazilian guidelines for the clinical management of paracoccidioidomycosis. ( 28746570 )
2017
12
Spontaneous pneumothorax in paracoccidioidomycosis patients from an endemic area in Midwestern Brazil. ( 27687259 )
2017
13
Therapeutic Response in Adult Patients with Nonsevere Chronic Paracoccidioidomycosis Treated with Sulfamethoxazole-Trimethoprim: A Retrospective Study. ( 28722596 )
2017
14
Altered distribution of peripheral blood dendritic cell subsets in patients with pulmonary paracoccidioidomycosis. ( 28606816 )
2017
15
Dendritic Cells Primed with Paracoccidioides brasiliensis Peptide P10 Are Therapeutic in Immunosuppressed Mice with Paracoccidioidomycosis. ( 28659882 )
2017
16
Th17-Inducing Cytokines IL-6 and IL-23 Are Crucial for Granuloma Formation during Experimental Paracoccidioidomycosis. ( 28871251 )
2017
17
Voice disorders in residual paracoccidioidomycosis in upper airways and digestive tract. ( 28583268 )
2017
18
Paracoccidioidomycosis: level of pulmonary sequelae in high resolution computed tomography images from patients of two endemic regions of Brazil. ( 28811998 )
2017
19
Sarcoid-like cutaneous lesions in chronic adult paracoccidioidomycosis: report of two cases. ( 28591264 )
2017
20
Peptide Vaccine Against Paracoccidioidomycosis. ( 28584987 )
2017
21
Hepatic Disease with Portal Hypertension and Acute Juvenile Paracoccidioidomycosis: A Report of Two Cases and Literature Review. ( 28577123 )
2017
22
Paracoccidioidomycosis and cryptococcosis with localized skin manifestations: report of two cases in the elderly. ( 27192530 )
2016
23
Amphotericin B lipid complex in the treatment of severe paracoccidioidomycosis: a case series. ( 27612594 )
2016
24
Severe Paracoccidioidomycosis in a 14-Year-Old Boy. ( 27364896 )
2016
25
Chronic Paracoccidioidomycosis with adrenal involvement mimicking tuberculosis - A case report from Austria. ( 27995053 )
2016
26
Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis. ( 27736987 )
2016
27
HIV Immune Recovery Inflammatory Syndrome and Central Nervous System Paracoccidioidomycosis. ( 27718161 )
2016
28
Photodynamic inactivation of oral paracoccidioidomycosis affecting woman with systemic lupus erythematosus: an unusual case report. ( 28012807 )
2016
29
Paracoccidioidomycosis: acute-subacute clinical form, juvenile type. ( 27438214 )
2016
30
Correction: Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis. ( 27992575 )
2016
31
Incubation Period and Early Natural History Events of the Acute Form of Paracoccidioidomycosis: Lessons from Patients with a Single Paracoccidioides spp. Exposure. ( 26687074 )
2016
32
PARACOCCIDIOIDOMYCOSIS IN A RENAL TRANSPLANT RECIPIENT. ( 26910451 )
2016
33
Musculoskeletal ultrasound findings in paracoccidioidomycosis. ( 27267337 )
2016
34
Current strategies for diagnosis of paracoccidioidomycosis and prospects of methods based on gold nanoparticles. ( 27416765 )
2016
35
Oral Paracoccidioidomycosis Granulomas are Predominantly Populated by CD163+ Multinucleated Giant Cells. ( 27236303 )
2016
36
Pulmonary paracoccidioidomycosis showing reversed halo sign with nodular/coarse contour. ( 26929466 )
2016
37
Paracoccidioides brasiliensis PS2: First Autochthonous Paracoccidioidomycosis Case Report in Rio de Janeiro, Brazil, and Literature Review. ( 27161127 )
2016
38
CHYLOTHORAX IN PARACOCCIDIOIDOMYCOSIS. ( 27410917 )
2016
39
Paracoccidioidomycosis in the spine: case report and review of the literature. ( 27355801 )
2016
40
Antifungal Activity of Amphotericin B Conjugated to Nanosized Magnetite in the Treatment of Paracoccidioidomycosis. ( 27303789 )
2016
41
Paracoccidioidomycosis in Brazilian Patients with and without Human Immunodeficiency Virus Infection. ( 27895278 )
2016
42
TLR 9 involvement in early protection induced by immunization with rPb27 against Paracoccidioidomycosis. ( 26597327 )
2016
43
Acute Respiratory Distress Syndrome in Lung Paracoccidioidomycosis. ( 26882163 )
2016
44
Acute Paracoccidioidomycosis Due to Paracoccidioides brasiliensis S1 Mimicking Hypereosinophilic Syndrome with Massive Splenomegaly: Diagnostic Challenge. ( 27054891 )
2016
45
Real Time Polymerase Chain Reaction (rt-PCR): A New Patent to diagnostic purposes for paracoccidioidomycosis. ( 27593543 )
2016
46
Polymorphisms on IFNG, IL12B and IL12RB1 genes and paracoccidioidomycosis in the Brazilian population. ( 27223631 )
2016
47
Complex nasal reconstruction after paracoccidioidomycosis infection--Case report. ( 26312717 )
2015
48
Advances and challenges in paracoccidioidomycosis serology caused by Paracoccidioides species complex: an update. ( 26494541 )
2015
49
PARACOCCIDIOIDOMYCOSIS TREATMENT. ( 26465367 )
2015
50
Hospital morbidity due to paracoccidioidomycosis in Brazil (1998-2006). ( 25645820 )
2015

Variations for Paracoccidioidomycosis

Expression for Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for Paracoccidioidomycosis

Pathways related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CD86 CTLA4 CXCL10 IFNG IL10 IL2
2
Show member pathways
13.69 CXCL10 IFNG IL10 IL2 IL4 IL5
3
Show member pathways
13.51 IFNG IL10 IL2 IL4 IL5 IL6
4
Show member pathways
13.48 CXCL10 IL10 IL2 IL4 IL5 IL6
5
Show member pathways
13.45 CD86 CXCL10 IFNG IL10 IL2 IL4
6
Show member pathways
13.32 CXCL10 IL10 IL2 IL4 IL5 IL6
7
Show member pathways
13.2 IFNG IL2 IL4 TLR2 TLR4 TNF
8
Show member pathways
12.94 CD86 CXCL10 IFNG IL10 IL2 IL6
9
Show member pathways
12.93 CXCL10 IFNG IL2 IL4 IL6 TLR2
10
Show member pathways
12.93 CD86 CTLA4 IFNG IL10 IL2 IL4
11
Show member pathways
12.74 IL2 IL6 TLR2 TLR4 TNF
12
Show member pathways
12.73 CD86 IFNG IL10 IL2 IL4 TNF
13 12.72 IL2 IL4 IL6 TLR2 TLR4 TNF
14 12.65 CTLA4 CXCL10 IFNG IL10 IL2 IL4
15
Show member pathways
12.64 IFNG IL10 IL2 IL6 TNF
16
Show member pathways
12.54 CTLA4 IFNG IL10 IL2 IL4 IL5
17
Show member pathways
12.52 IFNG IL2 IL4 TNF
18
Show member pathways
12.5 CXCL10 IFNG IL4 IL5 IL6 TLR2
19
Show member pathways
12.41 IFNG IL10 IL4 TLR2 TLR4 TNF
20
Show member pathways
12.39 CD86 IFNG IL10 IL2 IL4 IL5
21 12.38 IFNG IL10 IL6 TLR2 TLR4 TNF
22
Show member pathways
12.36 IFNG IL10 IL2 IL4 IL5 IL6
23
Show member pathways
12.32 CXCL10 IFNG IL4 IL6 TLR2 TLR4
24
Show member pathways
12.31 IFNG IL6 TLR4 TNF
25 12.3 IFNG IL6 TLR2 TLR4 TNF
26
Show member pathways
12.25 IFNG IL10 IL2 IL4 IL5 IL6
27 12.12 IL10 IL4 IL6 POMC TNF
28
Show member pathways
12.1 IL2 IL5 TLR2 TLR4
29 12.1 CXCL10 IFNG IL2 IL4 IL6 TLR4
30
Show member pathways
12.09 CD86 IFNG IL4 IL6 TLR2 TLR4
31 12.08 IFNG IL10 IL6 TLR2 TLR4 TNF
32 11.99 IL4 IL5 IL6 TNF
33 11.99 CD86 IFNG IL10 IL2 IL4 IL5
34 11.98 IFNG IL2 IL4 IL5 IL6 POMC
35
Show member pathways
11.97 IFNG IL2 IL4
36 11.96 IFNG IL10 IL2 IL6
37 11.96 IFNG IL10 IL2 IL4 IL5 TNF
38 11.95 CXCL10 IL6 TNF
39 11.93 IFNG IL10 IL2 IL6 TNF
40
Show member pathways
11.93 CTLA4 IFNG IL2 IL4 IL5 TNF
41 11.91 IFNG IL6 TLR4
42
Show member pathways
11.89 CD86 IFNG IL10 IL2 IL6 TLR2
43 11.88 IL2 POMC TLR4
44 11.88 IL10 IL6 TLR4 TNF
45 11.87 CD86 CTLA4 IFNG IL6 TLR2 TLR4
46 11.84 IFNG IL6 TLR4
47 11.79 IL4 IL5 IL6 TNF
48
Show member pathways
11.79 IFNG IL2 IL6 TNF
49 11.73 IL6 TLR2 TLR4 TNF
50 11.7 IL10 IL4 IL5

GO Terms for Paracoccidioidomycosis

Cellular components related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 CXCL10 IFNG IL10 IL2 IL4 IL5
2 extracellular space GO:0005615 9.61 CXCL10 IFNG IL10 IL2 IL4 IL5
3 external side of plasma membrane GO:0009897 9.23 CD86 CTLA4 CXCL10 IFNG IL4 IL6

Biological processes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 84)
id Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.99 CD86 CXCL10 IFNG IL6
2 inflammatory response GO:0006954 9.98 CXCL10 IL10 IL5 IL6 TLR2 TLR4
3 positive regulation of protein phosphorylation GO:0001934 9.97 IFNG IL2 IL4 TNF
4 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.96 CXCL10 IFNG IL10 IL2 IL4 IL6
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 IL6 TLR2 TLR4 TNF
6 response to virus GO:0009615 9.93 CXCL10 IFNG TNF
7 defense response to Gram-positive bacterium GO:0050830 9.91 IL6 TLR2 TNF
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.9 IL4 IL5 IL6
9 response to insulin GO:0032868 9.9 IL10 IL6 TLR2
10 response to glucocorticoid GO:0051384 9.89 IL10 IL6 TNF
11 positive regulation of inflammatory response GO:0050729 9.89 IL2 TLR2 TLR4
12 humoral immune response GO:0006959 9.88 IFNG IL6 TNF
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 IFNG IL2 IL4 IL6
14 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.88 IL10 IL4 IL5 IL6 TNF
15 response to lipopolysaccharide GO:0032496 9.88 CD86 CXCL10 IL10 IL6 TLR2 TLR4
16 positive regulation of tumor necrosis factor production GO:0032760 9.87 IFNG TLR2 TLR4
17 toll-like receptor signaling pathway GO:0002224 9.85 CD86 TLR2 TLR4
18 positive regulation of interferon-gamma production GO:0032729 9.85 IL2 TLR4 TNF
19 negative regulation of tumor necrosis factor production GO:0032720 9.85 IL10 POMC TLR4
20 positive regulation of interleukin-6 production GO:0032755 9.85 IL6 TLR2 TLR4 TNF
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IFNG IL6 TLR4 TNF
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.82 TLR2 TLR4 TNF
23 positive regulation of activated T cell proliferation GO:0042104 9.82 CD86 IL2 IL4
24 positive regulation of B cell proliferation GO:0030890 9.81 IL2 IL4 IL5 TLR4
25 positive regulation of interleukin-8 production GO:0032757 9.8 TLR2 TLR4 TNF
26 negative regulation of interleukin-6 production GO:0032715 9.79 IL10 TLR4 TNF
27 positive regulation of interleukin-12 production GO:0032735 9.79 IFNG TLR2 TLR4
28 positive regulation of interleukin-10 production GO:0032733 9.78 IL4 TLR2 TLR4
29 positive regulation of NF-kappaB import into nucleus GO:0042346 9.77 TLR2 TLR4 TNF
30 negative regulation of growth of symbiont in host GO:0044130 9.77 IFNG IL10 TNF
31 positive regulation of JAK-STAT cascade GO:0046427 9.76 IL5 IL6
32 positive regulation of T cell differentiation GO:0045582 9.76 IL2 IL4
33 myeloid dendritic cell differentiation GO:0043011 9.76 CD86 IL4
34 negative regulation of nitric oxide biosynthetic process GO:0045019 9.76 IL10 IL4
35 negative regulation of B cell proliferation GO:0030889 9.76 CTLA4 IL10
36 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.76 IFNG TNF
37 defense response to protozoan GO:0042832 9.76 IFNG IL10 IL4 IL6
38 microglial cell activation GO:0001774 9.75 IL4 TLR2
39 cellular response to hepatocyte growth factor stimulus GO:0035729 9.75 IL10 IL6
40 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.75 TLR2 TLR4
41 response to molecule of bacterial origin GO:0002237 9.75 IL10 TLR2
42 positive regulation of immunoglobulin secretion GO:0051024 9.75 IL2 IL5 IL6
43 response to auditory stimulus GO:0010996 9.74 CXCL10 IL6
44 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.74 IL10 TNF
45 I-kappaB phosphorylation GO:0007252 9.74 TLR2 TLR4
46 regulation of cytokine secretion GO:0050707 9.74 TLR2 TLR4
47 positive regulation of protein import into nucleus, translocation GO:0033160 9.74 IFNG IL6
48 positive regulation of isotype switching to IgG isotypes GO:0048304 9.74 IFNG IL2 IL4
49 positive regulation of podosome assembly GO:0071803 9.73 IL5 TNF
50 negative regulation of interleukin-17 production GO:0032700 9.73 IFNG TLR4

Molecular functions related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.46 CD86 CXCL10 IL6 POMC
2 growth factor activity GO:0008083 9.35 IL10 IL2 IL4 IL5 IL6
3 lipopolysaccharide receptor activity GO:0001875 9.26 TLR2 TLR4
4 cytokine activity GO:0005125 9.23 CXCL10 IFNG IL10 IL2 IL4 IL5

Sources for Paracoccidioidomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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