PCM
MCID: PRC002
MIFTS: 55

Paracoccidioidomycosis (PCM) malady

Categories: Rare diseases, Infectious diseases, Immune diseases

Aliases & Classifications for Paracoccidioidomycosis

Aliases & Descriptions for Paracoccidioidomycosis:

Name: Paracoccidioidomycosis 12 50 56 52 42 14 69
Mucocutaneous-Lymphangitic Paracoccidioidomycosis 12
Paracoccidioidomycosis, Unspecified 12
Lutz-Splendore-Almeida Disease 50
South American Blastomycosis 50
Paracoccidioidomycosis Nos 12
Paracoccidioidal Granuloma 50
Paracoccidioidal Mycosis 12
Lobo Disease 50
Lobomycosis 69
Pcm 50

Characteristics:

Orphanet epidemiological data:

56
paracoccidioidomycosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12662
ICD10 33 B41 B41.9
ICD9CM 35 116.1
MeSH 42 D010229
NCIt 47 C34891
Orphanet 56 ORPHA73260
ICD10 via Orphanet 34 B41.8 B41.9 B41.0 more
MESH via Orphanet 43 D010229
UMLS via Orphanet 70 C0030409
UMLS 69 C0030409

Summaries for Paracoccidioidomycosis

Disease Ontology : 12 A primary systemic mycosis that results_in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in Paracoccidioides brasiliensis.

MalaCards based summary : Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to tuberculosis and sarcoma. An important gene associated with Paracoccidioidomycosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include lung, bone and skin, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 71 Paracoccidioidomycosis (PCM) (also known as \"Brazilian blastomycosis,\" \"South American... more...

Related Diseases for Paracoccidioidomycosis

Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 288)
id Related Disease Score Top Affiliating Genes
1 tuberculosis 29.9 IL10 IL2 IL4 TNF
2 sarcoma 29.5 IL2 IL4
3 chorioretinitis 29.4 CTLA4 IFNG IL10 TNF
4 hepatitis 29.3 CTLA4 IFNG IL10 IL2 TNF
5 pulmonary tuberculosis 29.3 IFNG IL10 IL4 IL5 TLR4 TNF
6 rheumatoid arthritis 27.8 CD86 CTLA4 IFNG IL10 IL2 IL4
7 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
8 myoglobinuria recurrent 10.3 IFNG IL4
9 multiple vertebral anomalies unusual facies 10.3 IL10 TNF
10 stocco dos santos syndrome 10.2 IFNG TNF
11 ceroid lipofuscinosis, neuronal, 3 10.2 IL10 IL4
12 tubular renal disease-cardiomyopathy syndrome 10.2 IL10 IL4 TNF
13 senile reticular retinal degeneration 10.2 IFNG IL10 TNF
14 conduct disorder 10.2 IFNG IL10 TNF
15 gastroschisis abdominal wall defects, included 10.2 IFNG IL5
16 pancreatic signet ring cell adenocarcinoma 10.2 IFNG IL10 TNF
17 hereditary alpha tryptasemia syndrome 10.2 IFNG IL10 TNF
18 lagophthalmos 10.2 IL10 IL4 TNF
19 erb-duchenne and dejerine-klumpke palsies 10.2 IFNG IL10 TNF
20 low anorectal malformation 10.2 CTLA4 IL10 TNF
21 conidiobolomycosis 10.2 IL10 IL4 TNF
22 vestibule of mouth cancer 10.2 IL10 IL4 TNF
23 plummer's disease 10.2 IFNG IL10 TNF
24 bladder signet ring cell adenocarcinoma 10.2 CXCL10 IL10 TNF
25 aortic atherosclerosis 10.2 IL5 TNF
26 denys-drash syndrome 10.2 CTLA4 IFNG IL10
27 diabetic angiopathy 10.2 IL10 IL4
28 follicular adenoma 10.2 IFNG IL10 TNF
29 asymptomatic neurosyphilis 10.2 IFNG IL10 IL4
30 gonococcal endophthalmia 10.2 IL10 IL4 TNF
31 tungiasis 10.2 IFNG IL10 IL4
32 nguyen syndrome 10.2 IL10 TLR2
33 depressed scar 10.2 IFNG IL10 TNF
34 autosomal dominant intermediate charcot-marie-tooth 10.2 CTLA4 TNF
35 centronuclear myopathy 5 10.2 IFNG IL10 IL4
36 burns 10.2 IFNG IL10 TNF
37 immunodeficiency due to a late component of complement deficiency 10.2 CXCL10 IFNG IL10
38 classic type lipoma 10.2 IFNG IL10 TNF
39 hypotrichosis 4 10.2 IFNG IL4 TNF
40 vulvar nodular hidradenoma 10.2 IFNG IL10 TNF
41 astrocytoma 10.2 IL10 IL5 TNF
42 geniculate ganglionitis 10.2 IFNG IL10 TNF
43 fungal gastritis 10.2 IFNG IL10 TNF
44 oral cavity cancer 10.2 IFNG IL4 TNF
45 respiratory system disease 10.2 IFNG IL10 TNF
46 multiple mitochondrial dysfunctions syndrome 10.2 IFNG IL10 IL5
47 red cell phospholipid defect with hemolysis 10.2 IFNG IL4 TNF
48 distal trisomy 14q 10.2 IFNG TNF
49 hyperimmunoglobulin syndrome 10.2 CXCL10 IFNG TNF
50 orbit alveolar rhabdomyosarcoma 10.1 IL10 IL4 IL5

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to Paracoccidioidomycosis

Symptoms & Phenotypes for Paracoccidioidomycosis

MGI Mouse Phenotypes related to Paracoccidioidomycosis:

44 (show all 20)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 IFNG IL10 IL2 IL4 IL5 POMC
2 homeostasis/metabolism MP:0005376 10.3 CD86 CTLA4 CXCL10 IFNG IL10 IL2
3 immune system MP:0005387 10.29 CD86 CTLA4 CXCL10 IFNG IL10 IL2
4 cellular MP:0005384 10.27 CD86 CXCL10 IFNG IL10 IL2 IL4
5 behavior/neurological MP:0005386 10.24 IL5 POMC TLR2 TLR4 TNF CD86
6 cardiovascular system MP:0005385 10.24 TLR4 TNF CTLA4 CXCL10 IFNG IL10
7 digestive/alimentary MP:0005381 10.22 CTLA4 IFNG IL10 IL2 IL4 IL5
8 endocrine/exocrine gland MP:0005379 10.21 CD86 CTLA4 IFNG IL10 IL2 IL4
9 growth/size/body region MP:0005378 10.2 IFNG IL10 IL2 IL4 IL5 POMC
10 liver/biliary system MP:0005370 10.18 CTLA4 IFNG IL10 IL2 IL4 IL5
11 mortality/aging MP:0010768 10.16 CTLA4 CXCL10 IFNG IL10 IL2 IL4
12 integument MP:0010771 10.1 CTLA4 IFNG IL10 IL4 POMC TLR2
13 nervous system MP:0003631 10.02 CD86 CXCL10 IFNG IL10 IL4 POMC
14 neoplasm MP:0002006 10.01 TLR4 TNF IFNG IL10 IL2 IL5
15 muscle MP:0005369 9.91 CD86 IFNG IL10 TLR2 TLR4 TNF
16 respiratory system MP:0005388 9.81 TNF CTLA4 IFNG IL10 IL2 IL4
17 no phenotypic analysis MP:0003012 9.8 IL4 POMC TNF IFNG IL10 IL2
18 reproductive system MP:0005389 9.8 IFNG IL10 IL2 IL4 IL5 TLR4
19 skeleton MP:0005390 9.5 CTLA4 IFNG IL10 IL4 TLR2 TLR4
20 vision/eye MP:0005391 9.1 IFNG IL10 IL2 IL4 TLR4 TNF

Drugs & Therapeutics for Paracoccidioidomycosis

Search Clinical Trials , NIH Clinical Center for Paracoccidioidomycosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: paracoccidioidomycosis

Genetic Tests for Paracoccidioidomycosis

Anatomical Context for Paracoccidioidomycosis

MalaCards organs/tissues related to Paracoccidioidomycosis:

39
Lung, Bone, Skin, Lymph Node, T Cells, Testes, Monocytes

The Foundational Model of Anatomy Ontology organs/tissues related to Paracoccidioidomycosis:

18
Bone, Skin Or, Mucosa, Lymph Nodes

Publications for Paracoccidioidomycosis

Articles related to Paracoccidioidomycosis:

(show top 50) (show all 582)
id Title Authors Year
1
Spontaneous pneumothorax in paracoccidioidomycosis patients from an endemic area in Midwestern Brazil. ( 27687259 )
2017
2
Paracoccidioidomycosis and cryptococcosis with localized skin manifestations: report of two cases in the elderly. ( 27192530 )
2016
3
Amphotericin B lipid complex in the treatment of severe paracoccidioidomycosis: a case series. ( 27612594 )
2016
4
Current strategies for diagnosis of paracoccidioidomycosis and prospects of methods based on gold nanoparticles. ( 27416765 )
2016
5
Pulmonary paracoccidioidomycosis showing reversed halo sign with nodular/coarse contour. ( 26929466 )
2016
6
Correction: Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis. ( 27992575 )
2016
7
Oral Paracoccidioidomycosis Granulomas are Predominantly Populated by CD163+ Multinucleated Giant Cells. ( 27236303 )
2016
8
Paracoccidioidomycosis in Brazilian Patients with and without Human Immunodeficiency Virus Infection. ( 27895278 )
2016
9
Paracoccidioides brasiliensis PS2: First Autochthonous Paracoccidioidomycosis Case Report in Rio de Janeiro, Brazil, and Literature Review. ( 27161127 )
2016
10
Acute Paracoccidioidomycosis Due to Paracoccidioides brasiliensis S1 Mimicking Hypereosinophilic Syndrome with Massive Splenomegaly: Diagnostic Challenge. ( 27054891 )
2016
11
Photodynamic inactivation of oral paracoccidioidomycosis affecting woman with systemic lupus erythematosus: an unusual case report. ( 28012807 )
2016
12
Antifungal Activity of Amphotericin B Conjugated to Nanosized Magnetite in the Treatment of Paracoccidioidomycosis. ( 27303789 )
2016
13
Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis. ( 27736987 )
2016
14
TLR 9 involvement in early protection induced by immunization with rPb27 against Paracoccidioidomycosis. ( 26597327 )
2016
15
Real Time Polymerase Chain Reaction (rt-PCR): A New Patent to diagnostic purposes for paracoccidioidomycosis. ( 27593543 )
2016
16
PARACOCCIDIOIDOMYCOSIS IN A RENAL TRANSPLANT RECIPIENT. ( 26910451 )
2016
17
HIV Immune Recovery Inflammatory Syndrome and Central Nervous System Paracoccidioidomycosis. ( 27718161 )
2016
18
Chronic Paracoccidioidomycosis with adrenal involvement mimicking tuberculosis - A case report from Austria. ( 27995053 )
2016
19
Paracoccidioidomycosis in the spine: case report and review of the literature. ( 27355801 )
2016
20
Acute Respiratory Distress Syndrome in Lung Paracoccidioidomycosis. ( 26882163 )
2016
21
Polymorphisms on IFNG, IL12B and IL12RB1 genes and paracoccidioidomycosis in the Brazilian population. ( 27223631 )
2016
22
Incubation Period and Early Natural History Events of the Acute Form of Paracoccidioidomycosis: Lessons from Patients with a Single Paracoccidioides spp. Exposure. ( 26687074 )
2016
23
Musculoskeletal ultrasound findings in paracoccidioidomycosis. ( 27267337 )
2016
24
CHYLOTHORAX IN PARACOCCIDIOIDOMYCOSIS. ( 27410917 )
2016
25
Paracoccidioidomycosis: acute-subacute clinical form, juvenile type. ( 27438214 )
2016
26
Severe Paracoccidioidomycosis in a 14-Year-Old Boy. ( 27364896 )
2016
27
PARACOCCIDIOIDOMYCOSIS: CHALLENGES IN THE DEVELOPMENT OF A VACCINE AGAINST AN ENDEMIC MYCOSIS IN THE AMERICAS. ( 26465365 )
2015
28
Acute Disseminated Paracoccidioidomycosis with Molluscoid Lesions in a Young Woman. ( 25665493 )
2015
29
Advances and challenges in paracoccidioidomycosis serology caused by Paracoccidioides species complex: an update. ( 26494541 )
2015
30
Obstructive jaundice secondary to paracoccidioidomycosis. ( 26591954 )
2015
31
Concomitant pulmonary and central nervous system paracoccidioidomycosis with cerebellar abscess. ( 26676511 )
2015
32
Loss- and Gain-of-Function Approaches Indicate a Dual Role Exerted by Regulatory T Cells in Pulmonary Paracoccidioidomycosis. ( 26512987 )
2015
33
Neutrophil Extracellular Traps Identification in Tegumentary Lesions of Patients with Paracoccidioidomycosis and Different Patterns of NETs Generation In Vitro. ( 26327485 )
2015
34
scFv from Antibody That Mimics gp43 Modulates the Cellular and Humoral Immune Responses during Experimental Paracoccidioidomycosis. ( 26091522 )
2015
35
CT morphological features of the reversed halo sign in pulmonary paracoccidioidomycosis. ( 26329468 )
2015
36
PARACOCCIDIOIDOMYCOSIS TREATMENT. ( 26465367 )
2015
37
Cyclopalladated Compound 7a Induces Apoptosis- and Autophagy-Like Mechanisms in Paracoccidioides and Is a Candidate for Paracoccidioidomycosis Treatment. ( 26349827 )
2015
38
Synchronous Oral Paracoccidioidomycosis and Pulmonary Tuberculosis in an Immunocompetent Patient. ( 25652419 )
2015
39
Coinfection with tuberculosis and paracoccidioidomycosis in French Guiana: a common misdiagnosis. ( 26212497 )
2015
40
Immunodiagnosis of paracoccidioidomycosis due to Paracoccidioides brasiliensis using a latex test: detection of specific antibody anti-gp43 and specific antigen gp43. ( 25679976 )
2015
41
Paracoccidioidomycosis in patients with lymphoma and review of published literature. ( 25526930 )
2015
42
EXPERIMENTAL PARACOCCIDIOIDOMYCOSIS IN PREGNANT RATS. ( 27049707 )
2015
43
Cutaneous Paracoccidioidomycosis. ( 26333727 )
2015
44
Pentoxifylline immunomodulation in the treatment of experimental chronic pulmonary paracoccidioidomycosis. ( 26034509 )
2015
45
Magnetic resonance imaging findings of paracoccidioidomycosis in the musculoskeletal system. ( 26138054 )
2015
46
Paracoccidioidomycosis Mimicking Sarcoidosis: A Review of 8 Cases. ( 26363920 )
2015
47
High interleukin-4 expression and interleukin-4 gene polymorphisms are associated with susceptibility to human paracoccidioidomycosis. ( 26517657 )
2015
48
Expression of dectin-1 and enhanced activation of NALP3 inflammasome are associated with resistance to paracoccidioidomycosis. ( 26388856 )
2015
49
EPIDEMIOLOGY OF PARACOCCIDIOIDOMYCOSIS. ( 26465364 )
2015
50
Paracoccidioides-host Interaction: An Overview on Recent Advances in the Paracoccidioidomycosis. ( 26635779 )
2015

Variations for Paracoccidioidomycosis

Expression for Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for Paracoccidioidomycosis

Pathways related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 CD86 CTLA4 CXCL10 IFNG IL10 IL2
2
Show member pathways
13.63 CXCL10 IFNG IL10 IL2 IL4 IL5
3
Show member pathways
13.42 CXCL10 IL10 IL2 IL4 IL5 TLR2
4
Show member pathways
13.4 CD86 CXCL10 IFNG IL10 IL2 IL4
5
Show member pathways
13.26 CXCL10 IL10 IL2 IL4 IL5 TNF
6
Show member pathways
13.18 IFNG IL2 IL4 TLR2 TLR4 TNF
7
Show member pathways
12.96 CD86 CXCL10 IFNG IL10 IL2 TLR2
8
Show member pathways
12.89 CD86 CTLA4 IFNG IL10 IL2 IL4
9
Show member pathways
12.88 CXCL10 IFNG IL2 IL4 TLR2 TLR4
10
Show member pathways
12.7 CD86 IFNG IL10 IL2 IL4 TNF
11
Show member pathways
12.65 IL2 TLR2 TLR4 TNF
12 12.56 IL2 IL4 TLR2 TLR4
13
Show member pathways
12.56 IFNG IL10 IL2 TNF
14
Show member pathways
12.5 IFNG IL2 IL4 TNF
15 12.5 CTLA4 CXCL10 IFNG IL10 IL2 IL4
16
Show member pathways
12.48 CTLA4 IFNG IL10 IL2 IL4 IL5
17
Show member pathways
12.43 CXCL10 IFNG IL4 IL5 TLR2 TNF
18
Show member pathways
12.35 IFNG IL10 IL4 TLR2 TLR4 TNF
19
Show member pathways
12.35 CD86 IFNG IL10 IL2 IL4 IL5
20
Show member pathways
12.33 IFNG IL2 IL4 TNF
21 12.31 IFNG IL10 TLR2 TLR4 TNF
22
Show member pathways
12.29 IFNG IL10 IL2 IL4 IL5
23
Show member pathways
12.29 CXCL10 IFNG IL4 TLR2 TLR4 TNF
24
Show member pathways
12.24 IFNG IL10 IL2 IL4 IL5 TNF
25 12.21 IFNG TLR2 TLR4 TNF
26 12.09 CXCL10 IFNG IL2 IL4 TLR4 TNF
27
Show member pathways
12.07 IL2 IL5 TLR2 TLR4
28
Show member pathways
12.04 CD86 IFNG IL4 TLR2 TLR4
29 12.03 IL10 IL4 POMC TNF
30 12.01 IFNG IL10 TLR2 TLR4 TNF
31 11.98 CD86 IFNG IL10 IL2 IL4 IL5
32
Show member pathways
11.96 IFNG IL2 IL4
33 11.93 CD86 CTLA4 IFNG TLR2 TLR4 TNF
34 11.92 IFNG IL2 IL4 IL5 POMC
35 11.89 IL4 IL5 TNF
36 11.87 IL2 POMC TLR4
37 11.86 IFNG IL10 IL2 IL4 IL5 TNF
38 11.85 IFNG IL10 IL2 TNF
39
Show member pathways
11.83 CD86 IFNG IL10 IL2 TLR2 TLR4
40
Show member pathways
11.79 CTLA4 IFNG IL2 IL4 IL5 TNF
41 11.77 IL10 TLR4 TNF
42 11.72 IFNG IL10 IL2
43 11.68 IL10 IL4 IL5
44 11.68 IL4 IL5 TNF
45
Show member pathways
11.68 IFNG IL2 TNF
46
Show member pathways
11.66 IFNG IL2 TNF
47 11.66 CD86 CXCL10 IL10 IL4 TNF
48 11.66 IFNG IL10 TLR2 TLR4 TNF
49 11.64 IFNG TLR2 TLR4 TNF
50 11.61 TLR2 TLR4 TNF

GO Terms for Paracoccidioidomycosis

Cellular components related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 CXCL10 IFNG IL10 IL2 IL4 IL5
2 extracellular space GO:0005615 9.56 CXCL10 IFNG IL10 IL2 IL4 IL5
3 external side of plasma membrane GO:0009897 9.17 CD86 CTLA4 CXCL10 IFNG IL4 TLR4

Biological processes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.99 IFNG IL10 TLR4 TNF
2 cell-cell signaling GO:0007267 9.99 CD86 CXCL10 IL10 IL2 POMC
3 positive regulation of cell proliferation GO:0008284 9.99 CD86 CXCL10 IFNG IL2 IL4 IL5
4 adaptive immune response GO:0002250 9.98 CD86 CTLA4 IFNG IL2
5 positive regulation of protein phosphorylation GO:0001934 9.93 IFNG IL2 IL4 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 TLR2 TLR4 TNF
7 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.91 CXCL10 IFNG IL10 IL2 IL4 POMC
8 response to virus GO:0009615 9.9 CXCL10 IFNG TNF
9 response to lipopolysaccharide GO:0032496 9.88 CD86 CXCL10 IL10 TLR2 TLR4
10 positive regulation of inflammatory response GO:0050729 9.86 IL2 TLR2 TLR4
11 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.86 IL10 IL4 IL5 TNF
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 IFNG IL2 IL4
13 inflammatory response GO:0006954 9.85 CXCL10 IL10 IL5 TLR2 TLR4 TNF
14 positive regulation of tumor necrosis factor production GO:0032760 9.84 IFNG TLR2 TLR4
15 toll-like receptor signaling pathway GO:0002224 9.83 CD86 TLR2 TLR4
16 positive regulation of interferon-gamma production GO:0032729 9.83 IL2 TLR4 TNF
17 positive regulation of interleukin-6 production GO:0032755 9.83 TLR2 TLR4 TNF
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 IFNG TLR4 TNF
19 negative regulation of tumor necrosis factor production GO:0032720 9.81 IL10 POMC TLR4
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 TLR2 TLR4 TNF
21 positive regulation of activated T cell proliferation GO:0042104 9.79 CD86 IL2 IL4
22 positive regulation of interleukin-8 production GO:0032757 9.78 TLR2 TLR4 TNF
23 negative regulation of interleukin-6 production GO:0032715 9.77 IL10 TLR4 TNF
24 positive regulation of interleukin-12 production GO:0032735 9.76 IFNG TLR2 TLR4
25 positive regulation of T cell proliferation GO:0042102 9.76 CD86 IFNG IL2 IL4
26 negative regulation of osteoclast differentiation GO:0045671 9.74 IL4 TLR4
27 negative regulation of myoblast differentiation GO:0045662 9.74 CXCL10 TNF
28 positive regulation of osteoclast differentiation GO:0045672 9.74 IFNG TNF
29 positive regulation of T cell differentiation GO:0045582 9.74 IL2 IL4
30 myeloid dendritic cell differentiation GO:0043011 9.74 CD86 IL4
31 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.74 IL2 IL4
32 positive regulation of interleukin-10 production GO:0032733 9.74 IL4 TLR2 TLR4
33 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.73 IL10 TNF
34 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IFNG TNF
35 negative regulation of B cell proliferation GO:0030889 9.73 CTLA4 IL10
36 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.73 TLR2 TLR4
37 microglial cell activation GO:0001774 9.73 IL4 TLR2
38 negative regulation of nitric oxide biosynthetic process GO:0045019 9.72 IL10 IL4
39 response to molecule of bacterial origin GO:0002237 9.72 IL10 TLR2
40 I-kappaB phosphorylation GO:0007252 9.72 TLR2 TLR4
41 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL10 TNF
42 positive regulation of NF-kappaB import into nucleus GO:0042346 9.72 TLR2 TLR4 TNF
43 positive regulation of podosome assembly GO:0071803 9.71 IL5 TNF
44 regulation of cytokine secretion GO:0050707 9.71 TLR2 TLR4
45 positive regulation of immunoglobulin secretion GO:0051024 9.71 IL2 IL5
46 negative regulation of interleukin-17 production GO:0032700 9.71 IFNG TLR4
47 defense response to protozoan GO:0042832 9.71 IFNG IL10 IL4
48 cellular response to lipoteichoic acid GO:0071223 9.7 TLR2 TLR4
49 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.7 TLR4 TNF
50 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF

Molecular functions related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 IL10 IL2 IL4 IL5
2 cytokine activity GO:0005125 9.17 CXCL10 IFNG IL10 IL2 IL4 IL5
3 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4

Sources for Paracoccidioidomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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