PCM
MCID: PRC002
MIFTS: 64

Paracoccidioidomycosis (PCM) malady

Rare diseases, Infectious diseases, Immune diseases, Bone diseases, Skin diseases categories
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Summaries for Paracoccidioidomycosis

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in paracoccidioides brasiliensis.

MalaCards: Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to tuberculosis and hepatitis. An important gene associated with Paracoccidioidomycosis is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Immune response Bacterial infections in normal airways and TNF signaling pathway. The drugs ketoconazole and itraconazole and the compounds glatiramer acetate and p 277 have been mentioned in the context of this disorder. Affiliated tissues include bone, skin or and lymph nodes, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Wikipedia:65 Paracoccidioidomycosis (also known as \"Brazilian blastomycosis,\" \"South American... more...

Aliases & Classifications for Paracoccidioidomycosis

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 26ICD10 via Orphanet, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

49
paracoccidioidomycosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

paracoccidioidomycosis 8 43 45 49 62
mucocutaneous-lymphangitic paracoccidioidomycosis 8
paracoccidioidomycosis, unspecified 8
lutz-splendore-almeida disease 43
south american blastomycosis 43
protein-energy malnutrition 62
paracoccidioidomycosis nos 8
paracoccidioidal granuloma 43
paracoccidioidal mycosis 8
lobo disease 43
pcm 43


External Ids:

Disease Ontology8 DOID:12662
ICD9CM27 116.1
NCIt40 C34891
MeSH35 D010229
ICD10 via Orphanet26 B41.7, B41.8, B41.9 B41.0, more
MESH via Orphanet36 D010229
SNOMED-CT via Orphanet59 59925007
UMLS via Orphanet63 C0030409
ICD1025 B41, B41.9

Related Diseases for Paracoccidioidomycosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.3TNFRSF1A, HSPD1, TPI1, CXCL10, IL10
2hepatitis30.2TNFRSF1A, CXCL10
3vasculitis29.9CTLA4, HSPD1
4periodontitis29.9HSPD1, IL10
5hepatitis c29.9IL10, CXCL10, HSPD1
6septic shock29.8TNFRSF1A, IL10
7lung cancer29.7CTLA4, TPI1, HSPD1, TNFRSF1A
8arthritis29.7CTLA4, IL10, CXCL10, HSPD1, TNFRSF1A
9rheumatoid arthritis29.7TNFRSF1A, HSPD1, CXCL10, IL10, CTLA4
10blastomycosis10.4
11histoplasmosis10.3
12pulmonary tuberculosis10.2
13lobomycosis10.2
14laryngitis10.2
15prostatitis10.2
16vulvovaginitis10.1HSPD1
17meningitis10.1CXCL10
18trachoma10.1HSPD1
19stenotrophomonas maltophilia10.1
20acquired immunodeficiency syndrome10.1
21hypercalcemia10.1
22cervicitis10.1
23esophagitis10.1
24gingivitis10.1
25osteomyelitis10.1
26sarcoma10.1
27mycetoma10.1
28arthropathy10.1CTLA4, CXCL10
29behcet's disease10.1CTLA4, HSPD1
30autoimmune hepatitis10.0CTLA4, HSPD1
31connective tissue disease10.0CTLA4, IL10
32dermatitis10.0CTLA4, CXCL10
33primary biliary cirrhosis10.0CTLA4, HSPD1
34myasthenia gravis10.0IL10, CTLA4
35lepromatous leprosy10.0IL10, HSPD1
36atopy10.0IL10, CTLA4
37plasmodium falciparum malaria10.0IL10, TPI1
38graves' disease10.0CXCL10, CTLA4
39allergic rhinitis10.0CTLA4, IL10
40tetanus10.0IL10, HSPD1
41periodontal disease10.0CTLA4, CXCL10, HSPD1
42ankylosing spondylitis10.0TNFRSF1A, HSPD1
43type 1 diabetes mellitus10.0HSPD1, CXCL10, CTLA4
44hepatitis b10.0CTLA4, IL10, CXCL10
45common variable immune deficiency10.0IL10, TNFRSF1A
46encephalomyelitis10.0CTLA4, IL10, CXCL10
47neutropenia10.0CXCL10, TNFRSF1A
48leishmaniasis10.0IL10, TNFRSF1A
49atopic dermatitis10.0CTLA4, IL10, CXCL10
50ulcerative colitis10.0CXCL10, IL10, CTLA4

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to paracoccidioidomycosis

Symptoms for Paracoccidioidomycosis

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Drugs & Therapeutics for Paracoccidioidomycosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Paracoccidioidomycosis

Search NIH Clinical Center for Paracoccidioidomycosis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Paracoccidioidomycosis

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Anatomical Context for Paracoccidioidomycosis

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Paracoccidioidomycosis:

33
Bone, Skin, Lung, Lymph node, T cells, Testes, Monocytes, Prostate, Bone marrow, Adrenal gland, B cells, Spinal cord, Myeloid, Colon, Thymus, Spleen

FMA organs/tissues related to Paracoccidioidomycosis:

14
Bone, Skin or, Lymph nodes, Mucosa

Animal Models for Paracoccidioidomycosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Paracoccidioidomycosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2CTLA4, IL10, CXCL10, TNFRSF1A
2MP:00053977.6TNFRSF1A, TPI1, CXCL10, IL10, CTLA4
3MP:00053877.5TNFRSF1A, TPI1, CXCL10, IL10, CTLA4
4MP:00053767.3TNFRSF1A, TPI1, CXCL10, IL10, CTLA4
5MP:00107687.2CTLA4, IL10, CXCL10, TPI1, HSPD1, TNFRSF1A

Publications for Paracoccidioidomycosis

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Sources:
52PubMed
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Articles related to Paracoccidioidomycosis:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
The role of leukotriene B4 in early stages of experimental paracoccidioidomycosis induced in phenotypically selected mouse strains. (23534453)
2013
2
Paracoccidioidomycosis simulating a soft tissue tumor. (24261836)
2013
3
The pivotal role of 5-lipoxygenase-derived LTB4 in controlling pulmonary paracoccidioidomycosis. (23991239)
2013
4
Chronic paracoccidioidomycosis of the intestine as single organ involvement points to an alternative pathogenesis of the mycosis. (23982286)
2013
5
The left lung is preferentially targeted during experimental paracoccidioidomycosis in C57BL/6 mice. (24141611)
2013
6
Serological survey of paracoccidioidomycosis in cats. (23912468)
2013
7
Regulatory T cells in cutaneous lesions of patients withA Paracoccidioidomycosis. (24107311)
2013
8
Osteomyelitis and pyoarthritis resulting from local paracoccidioidomycosis in an immunocompetent patient: a case report. (23043817)
2012
9
Synchronous oral paracoccidioidomycosis and esophageal carcinoma. (22371017)
2012
10
Paracoccidioidomycosis: another cause of sternal osteomyelitis. (22401786)
2012
11
Paracoccidioidomycosis: high-resolution computed tomography-pathologic correlation. (19608361)
2011
12
Seropositive antiaquaporin-4 antibody associated with multisegmental myelitis in a patient with paracoccidioidomycosis. (21803375)
2011
13
Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis. (22046142)
2011
14
Analysis of invariant natural killer T cells in human paracoccidioidomycosis. (21805204)
2011
15
Gastrointestinal paracoccidioidomycosis: an overview. (20975575)
2011
16
Paracoccidioidomycosis in a dog: case report of generalized lymphadenomegaly. (21424604)
2011
17
Histoplasmosis and paracoccidioidomycosis in a non-endemic area: a review of cases and diagnosis. (21199139)
2011
18
Altered ex vivo expression of caspase 8, caspase 9, and Bcl-2 is associated with T-cell hyporeactivity in patients with paracoccidioidomycosis. (19386797)
2009
19
Oral paracoccidioidomycosis and pulmonary tuberculosis co-infection: relevance of oral biopsy in establishing the diagnosis and therapeutic approach. (18650110)
2009
20
Inducible nitric oxide synthase-deficient mice show exacerbated inflammatory process and high production of both Th1 and Th2 cytokines during paracoccidioidomycosis. (19063988)
2009
21
Hypercalcemia in a patient with disseminated paracoccidioidomycosis: a case report. (18691418)
2008
22
Experimental paracoccidioidomycosis: alternative therapy with ajoene, compound from Allium sativum, associated with sulfamethoxazole/trimethoprim. (18324489)
2008
23
Use of recombinant gp43 isoforms expressed in Pichia pastoris for diagnosis of paracoccidioidomycosis. (18235042)
2008
24
Characterization of inflammatory cells in oral paracoccidioidomycosis. (17577332)
2007
25
An open-label comparative pilot study of oral voriconazole and itraconazole for long-term treatment of paracoccidioidomycosis. (17990229)
2007
26
Neutrophil role in pulmonary paracoccidioidomycosis depends on the resistance pattern of hosts. (16603588)
2006
27
Infiltrative myelopathy by paracoccidioidomycosis. A review and report of nine cases with emphasis on bone marrow morphology. (16487359)
2006
28
The role of interleukin-10 in the differential expression of interleukin-12p70 and its beta2 receptor on patients with active or treated paracoccidioidomycosis and healthy infected subjects. (15596413)
2005
29
Absence of interleukin-4 determines less severe pulmonary paracoccidioidomycosis associated with impaired Th2 response. (15039362)
2004
30
Paracoccidioidomycosis in a woman with idiopathic hirsutism. (15487322)
2004
31
Paracoccidioidomycosis associated with human immunodeficiency virus infection. Report of 10 cases. (12964719)
2003
32
Paracoccidioidomycosis of the mouth: an emerging deep mycosis. (14530306)
2003
33
Unique adrenal gland imaging features in Addison's disease caused by paracoccidioidomycosis. (14573459)
2003
34
Dendritic cells and pattern of cytokines in paracoccidioidomycosis skin lesions. (12652191)
2003
35
Paracoccidioidomycosis mortality in Brazil (1980-1995). (12244377)
2002
36
Anti-gp43 antibodies in the cerebrospinal fluid of patients with central nervous system involvement by paracoccidioidomycosis. (12472279)
2002
37
Cytokines and lymphocyte proliferation in juvenile and adult forms of paracoccidioidomycosis: comparison with infected and non-infected controls. (11880044)
2002
38
Paracoccidioidomycosis: report of 2 cases mimicking squamous cell carcinoma. (12424456)
2002
39
Levels of specific antigen (gp43), specific antibodies, and antigen-antibody complexes in saliva and serum of paracoccidioidomycosis patients. (12054053)
2001
40
Canine paracoccidioidomycosis: a seroepidemiologic study. (11446531)
2001
41
Fibrotic sequelae in pulmonary paracoccidioidomycosis: histopathological aspects in BALB/c mice infected with viable and non-viable paracoccidioides brasiliensis propagules. (10810319)
2000
42
DNA-based vaccination against murine paracoccidioidomycosis using the gp43 gene from paracoccidioides brasiliensis. (10825609)
2000
43
Central nervous system paracoccidioidomycosis. Report of a case successfully treated with itraconazol. (10968887)
2000
44
Experimental paracoccidioidomycosis of the Syrian hamster: fungicidal activity and production of inflammatory cytokines by macrophages. (10746228)
2000
45
Endemic regions of paracoccidioidomycosis in Brazil: a clinical and epidemiologic study of 584 cases in the southeast region. (10497977)
1999
46
Hypercalcaemia and paracoccidioidomycosis. (9764330)
1998
47
Aspergillus fumigatus fungus ball in a patient with healed paracoccidioidomycosis. (9431402)
1997
48
Paracoccidioidomycosis in a boy infected with HIV. (9470418)
1997
49
The role of somatic structure of the fungus Paracoccidioides brasiliensis upon B cell activation in experimental paracoccidioidomycosis. (7648716)
1995
50
Paracoccidioidomycosis and its etiologic agent Paracoccidioides brasiliensis. (8509955)
1993

Variations for Paracoccidioidomycosis

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Expression for genes affiliated with Paracoccidioidomycosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for genes affiliated with Paracoccidioidomycosis

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50PathCards, 60Thomson Reuters, 30KEGG, 54R&D Systems, 53QIAGEN, 38NCBI BioSystems Database
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Pathways related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.2CXCL10, TNFRSF1A
29.2CXCL10, TNFRSF1A
3
Show member pathways
9.0IL10, TNFRSF1A
4
Show member pathways
8.6TNFRSF1A, CXCL10, IL10
5
Show member pathways
8.6TNFRSF1A, CXCL10, IL10
6
Show member pathways
8.6TNFRSF1A, CXCL10, IL10
7
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.6TNFRSF1A, CXCL10, IL10
88.5IL10, HSPD1, TNFRSF1A
9
Show member pathways
8.1CTLA4, IL10, HSPD1, TNFRSF1A

Compounds for genes affiliated with Paracoccidioidomycosis

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 3BitterDB, 29IUPHAR
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Compounds related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1glatiramer acetate45 1110.8IL10, CTLA4
2p 277459.8IL10, HSPD1
3bifidobacterium459.7HSPD1, IL10
4indoleamine459.7CTLA4, IL10
5toxin-1459.7IL10, HSPD1
6tuberculin459.7HSPD1, IL10
7groalpha459.6CXCL10, IL10
8isocitrate459.6HSPD1, TPI1
9con a459.6IL10, CTLA4
10polymyxin b459.6IL10, HSPD1
11iodine45 2410.5TNFRSF1A, CTLA4
122,5-oligoadenylate459.5CXCL10, IL10
13il 10459.4CTLA4, IL10, CXCL10
14allergens459.4CXCL10, IL10, CTLA4
15blys459.4IL10, TNFRSF1A
16polyinosinic-polycytidylic acid459.4CXCL10, IL10
17tacrolimus45 51 1111.4CXCL10, IL10, CTLA4
18adalimumab45 51 1111.3TNFRSF1A, IL10
19vitamin d459.2CXCL10, IL10, CTLA4
20okt3459.2TNFRSF1A, IL10
21manganese superoxide459.0TNFRSF1A, HSPD1, TPI1
22thalidomide45 51 61 1112.0TNFRSF1A, IL10, CTLA4
23tgf beta1459.0CTLA4, IL10, TNFRSF1A
24ionomycin459.0TNFRSF1A, IL10, CTLA4
25neopterin459.0IL10, CXCL10, TNFRSF1A
26chloroquine45 3 51 29 1113.0TNFRSF1A, CXCL10, IL10
27methotrexate51 45 1111.0CTLA4, IL10, TNFRSF1A
28etanercept45 51 1110.7TNFRSF1A, IL10
29phosphatidylinositol458.6TNFRSF1A, HSPD1, CXCL10, CTLA4
30paraffin458.6IL10, HSPD1, TNFRSF1A
31infliximab45 51 1110.6TNFRSF1A, CXCL10, IL10, CTLA4
32alanine458.6TNFRSF1A, HSPD1, CXCL10, CTLA4
33superoxide45 249.6TPI1, HSPD1, TNFRSF1A
34estrogen458.6CTLA4, CXCL10, HSPD1, TNFRSF1A
35creatinine458.6TNFRSF1A, HSPD1, TPI1, CXCL10
36glutamate458.6TNFRSF1A, HSPD1, TPI1, CTLA4
37cyclosporin a45 29 6110.5CTLA4, IL10, HSPD1, TNFRSF1A
38cysteine458.5CTLA4, TPI1, HSPD1, TNFRSF1A
39endotoxin458.5TNFRSF1A, HSPD1, CXCL10, IL10
40pge2458.5IL10, CXCL10, TNFRSF1A
41atp45 299.5TNFRSF1A, HSPD1, TPI1, CXCL10
42cycloheximide458.5IL10, CXCL10, HSPD1, TNFRSF1A
43vegf458.4IL10, CXCL10, HSPD1, TNFRSF1A
44aspartate458.4TNFRSF1A, HSPD1, TPI1, IL10
45cholesterol45 29 24 1111.2CTLA4, CXCL10, TPI1, HSPD1, TNFRSF1A
46glucose458.2TNFRSF1A, HSPD1, TPI1, CXCL10, CTLA4
47lipid458.2TNFRSF1A, HSPD1, TPI1, CXCL10, CTLA4
48tyrosine458.1TNFRSF1A, HSPD1, TPI1, CXCL10, CTLA4
49rantes458.1CTLA4, IL10, CXCL10, HSPD1, TNFRSF1A
50dexamethasone45 51 29 1111.1TNFRSF1A, HSPD1, CXCL10, IL10, CTLA4

GO Terms for genes affiliated with Paracoccidioidomycosis

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16Gene Ontology
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Cellular components related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.5IL10, CXCL10, TPI1, HSPD1, TNFRSF1A

Biological processes related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of B cell proliferationGO:0308899.7CTLA4, IL10
2negative regulation of T cell proliferationGO:0421309.5IL10, CTLA4
3B cell proliferationGO:0421009.4IL10, HSPD1
4cellular response to estradiol stimulusGO:0713929.2IL10, TNFRSF1A
5negative regulation of interleukin-6 productionGO:0327159.2IL10, TNFRSF1A
6response to lipopolysaccharideGO:0324969.2CXCL10, TNFRSF1A
7defense response to bacteriumGO:0427428.9TNFRSF1A, IL10
8inflammatory responseGO:0069548.7TNFRSF1A, CXCL10, IL10
9negative regulation of apoptotic processGO:0430668.5IL10, HSPD1, TNFRSF1A
10positive regulation of transcription from RNA polymerase II promoterGO:0459448.3IL10, CXCL10, TNFRSF1A

Products for genes affiliated with Paracoccidioidomycosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Paracoccidioidomycosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet