PCM
MCID: PRC002
MIFTS: 70

Paracoccidioidomycosis (PCM) malady

Infectious diseases, Immune diseases categories

Summaries for Paracoccidioidomycosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in paracoccidioides brasiliensis.

MalaCards: Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to thyroiditis and malaria. An important gene associated with Paracoccidioidomycosis is CXCL10 (chemokine (C-X-C motif) ligand 10), and among its related pathways are Cell adhesion molecules (CAMs) and Regulation by c-FLIP. The drugs ketoconazole and itraconazole and the compounds cyclosporin a and rantes have been mentioned in the context of this disorder. Affiliated tissues include mucosa, skin or and bone, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Wikipedia:63 Paracoccidioidomycosis (also known as \"Brazilian blastomycosis,\" \"South American... more...

Aliases & Classifications for Paracoccidioidomycosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Immune diseases


Characteristics (Orphanet epidemiological data):

48
paracoccidioidomycosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

paracoccidioidomycosis 8 42 44 48 60
mucocutaneous-lymphangitic paracoccidioidomycosis 8
paracoccidioidomycosis, unspecified 8
lutz-splendore-almeida disease 42
south american blastomycosis 42
protein-energy malnutrition 60
paracoccidioidomycosis nos 8
paracoccidioidal granuloma 42
paracoccidioidal mycosis 8
lobo disease 42
pcm 42


External Ids:

Disease Ontology8 DOID:12662
NCIt39 C34891
MeSH34 D010229
ICD9CM27 116.1
ICD10 via Orphanet26 B41.7, B41.8, B41.9 B41.0, more
MESH via Orphanet35 D010229
SNOMED-CT via Orphanet57 59925007
UMLS via Orphanet61 C0030409
ICD1025 B41, B41.9

Related Diseases for Paracoccidioidomycosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 224)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.9FASLG, CTLA4
2malaria30.8GSR, TPI1, IL10, CXCL9, G6PD, HSPD1
3ischemia30.7GSR
4cystic fibrosis30.4TLR4
5leukemia30.4TNFRSF1A, GLO1, FASLG, TLR4
6tuberculosis30.4GSR, TPI1, IL10, CXCL9, CXCL10, MYD88
7dilated cardiomyopathy30.2HSPD1
8meningitis30.2CXCL10
9influenza30.2CD28, CXCL10, MYD88, CXCL9
10deficiency anemia30.2TPI1, GSR, G6PD
11viral hepatitis30.2FASLG, G6PD, TNFRSF1A
12leishmaniasis30.2TNFRSF1A, GLO1, IL10, IL5
13alzheimer's disease30.2GLO1, TPI1, GSR, TNFRSF1A
14tetanus30.2HSPD1, IL10, IL5, CD28
15inflammatory bowel disease30.2HSPD1, TLR4, IL10, TNFRSF1A, CTLA4, CXCL10
16hepatitis30.1GSR, CXCL10, FASLG, TNFRSF1A
17squamous cell carcinoma30.1FASLG, CTLA4, GLO1, CKS1B, TPI1, CXCL9
18cervicitis30.0HSPD1
19gingivitis30.0HSPD1
20esophagitis30.0IL5
21pancreatitis29.8IL10
22vasculitis29.8HSPD1, CTLA4
23colon cancer29.8HSPD1, FASLG
24silicosis29.8FASLG
25sarcoidosis29.8CD28, CXCL10, CXCL9, IL12RB2
26schistosomiasis29.8IL10, GSR, IL5
27periodontitis29.8HSPD1, TLR4, IL10
28pneumonia29.8IL5, IL10, MYD88, CXCL10, TLR4
29hepatitis c29.8IL10, CXCL10, CD28, CTLA4, TLR4, GSR
30prostate cancer29.8FASLG, GSR, TPI1, CXCL10, GLO1, CTLA4
31arthritis29.8CTLA4, TNFRSF1A, TLR4, HSPD1, CXCL10, CXCL9
32lung cancer29.8TLR4, HSPD1, TNFRSF1A, GSR, CTLA4, GLO1
33rheumatoid arthritis29.8CXCL10, FASLG, PDCD1, CXCL9, HSPD1, TLR4
34protein-energy malnutrition11.5
35kwashiorkor10.6
36marasmus10.5
37liver cirrhosis10.5
38peritonitis10.5
39cerebritis10.4
40measles10.4
41blastomycosis10.3
42biotin deficiency10.3
43lactose intolerance10.3
44cerebral malaria10.3
45acute leukemia10.3
46neuroblastoma10.3
47histoplasmosis10.3
48burns10.2
49acute diarrhea10.2
50visceral leishmaniasis10.2

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to paracoccidioidomycosis

Clinical Features for Paracoccidioidomycosis

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Drugs & Therapeutics for Paracoccidioidomycosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Paracoccidioidomycosis

Search NIH Clinical Center for Paracoccidioidomycosis

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Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Paracoccidioidomycosis

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Anatomical Context for Paracoccidioidomycosis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Paracoccidioidomycosis:

32
Bone, Skin, Lung, Lymph node, T cells, Testes, Monocytes, Bone marrow, Prostate, Adrenal gland, Spleen, Spinal cord, Thymus, Myeloid, Colon, B cells

FMA organs/tissues related to Paracoccidioidomycosis:

14
Mucosa, Skin or, Bone, Lymph nodes

Animal Models for Paracoccidioidomycosis or affiliated genes

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36MGI
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Publications for Paracoccidioidomycosis

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50PubMed
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Articles related to Paracoccidioidomycosis:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
The pivotal role of 5-lipoxygenase-derived LTB4 in controlling pulmonary paracoccidioidomycosis. (23991239)
2013
2
Neutrophils in oral paracoccidioidomycosis and the involvement of nrf2. (24204715)
2013
3
The lung in paracoccidioidomycosis: new insights into old problems. (23778339)
2013
4
Paracoccidioidomycosis simulating cancer diagnosed by endoscopic ultrasound-guided fine needle aspiration. (23258492)
2012
5
Carpal tunnel syndrome with paracoccidioidomycosis. (22840753)
2012
6
Treatment of severe forms of paracoccidioidomycosis: is there a role for corticosteroids? (22309459)
2012
7
Paracoccidioidomycosis: high-resolution computed tomography-pathologic correlation. (19608361)
2011
8
Hormones and the resistance of women to paracoccidioidomycosis. (21482727)
2011
9
Paracoccidioidomycosis epidemiological features of a 1,000-cases series from a hyperendemic area on the southeast of Brazil. (21896820)
2011
10
Multifocal paracoccidioidomycosis: a diagnostic challenge due to late cutaneous manifestation. (21437540)
2011
11
Imported acute and isolated glottic paracoccidioidomycosis. (20336918)
2010
12
Chronic diarrhea and pancolitis caused by paracoccidioidomycosis: a case report. (20671977)
2010
13
Protein-losing enteropathy in paracoccidioidomycosis identified by scintigraphy: report of three cases. (21221488)
2010
14
Pulmonary paracoccidioidomycosis. (18366000)
2008
15
Report of an imported cutaneous disseminated case of paracoccidioidomycosis. (17592892)
2007
16
Pulmonary paracoccidioidomycosis and AIDS: high-resolution CT findings in five patients. (17882041)
2007
17
Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis. (17302897)
2007
18
B1 cells contribution to susceptibility in experimental paracoccidioidomycosis: immunoglobulin isotypes and repertoire determination. (17127633)
2006
19
Dysphonia and laryngeal sequelae in paracoccidioidomycosis patients: a morphological and phoniatric study. (16702100)
2006
20
Contribution to the natural history of paracoccidioidomycosis: identification of the primary pulmonary infection in the severe acute form of the disease--a case report. (15614683)
2005
21
Membrane and extracellular antigens of Paracoccidioides brasiliensis (Mexo): identification of a 28-kDa protein suitable for immunodiagnosis of paracoccidioidomycosis. (16269152)
2005
22
Reactivity of antibodies from patients with acute and chronic paracoccidioidomycosis to a high molecular mass antigen from Paracoccidioides brasiliensis. (16170813)
2005
23
Paracoccidioidomycosis: an epidemiologic survey in a pediatric population from the Brazilian Amazon using skin tests. (15238694)
2004
24
Central nervous system paracoccidioidomycosis: case report and review. (15469072)
2004
25
Dual role of interleukin-4 (IL-4) in pulmonary paracoccidioidomycosis: endogenous IL-4 can induce protection or exacerbation of disease depending on the host genetic pattern. (15213137)
2004
26
Dendritic cells and pattern of cytokines in paracoccidioidomycosis skin lesions. (12652191)
2003
27
Evaluation of bronchoalveolar cells in pulmonary paracoccidioidomycosis. (14680075)
2003
28
Immunocytochemical localization of cytokines and inducible nitric oxide synthase (iNOS) in oral mucosa and lymph nodes of patients with paracoccidioidomycosis. (12824008)
2003
29
Study of bronchoalveolar lavage fluid in paracoccidioidomycosis: cytopathology and alveolar macrophage function in response to gamma interferon; comparison with blood monocytes. (14670450)
2003
30
Experimental paracoccidioidomycosis in dogs. (12964720)
2003
31
Anti-gp43 antibodies in the cerebrospinal fluid of patients with central nervous system involvement by paracoccidioidomycosis. (12472279)
2002
32
Cytokines and lymphocyte proliferation in juvenile and adult forms of paracoccidioidomycosis: comparison with infected and non-infected controls. (11880044)
2002
33
Dual role for nitric oxide in paracoccidioidomycosis: essential for resistance, but overproduction associated with susceptibility. (11971007)
2002
34
Parinaud'S oculoglandular syndrome associated with paracoccidioidomycosis. (11896412)
2002
35
Paracoccidioidomycosis in Colombia: an ecological study. (11349982)
2001
36
Central nervous system paracoccidioidomycosis. Report of a case successfully treated with itraconazol. (10968887)
2000
37
Intestinal paracoccidioidomycosis simulating colon cancer. (10967600)
2000
38
Central nervous system paracoccidioidomycosis: case report. (11203504)
2000
39
A case of paracoccidioidomycosis: experience with long-term therapy. (10782401)
2000
40
PCR for diagnosis of paracoccidioidomycosis. (10970409)
2000
41
Production of IFN-gamma is impaired in patients with paracoccidioidomycosis during active disease and is restored after clinical remission. (10892991)
2000
42
Detection of circulating Paracoccidioides brasiliensis antigen in urine of paracoccidioidomycosis patients before and during treatment. (9620407)
1998
43
Monocyte adherence to Paracoccidioides brasiliensis, zymosan-C3b and erythrocyte-hemolysin in patients with paracoccidioidomycosis. (9433808)
1997
44
Lung tissue mechanics in the early stages of induced paracoccidioidomycosis in rats. (9496434)
1997
45
The use of glucan as immunostimulant in the treatment of paracoccidioidomycosis. (8940980)
1996
46
Pulmonary paracoccidioidomycosis in resistant and susceptible mice: relationship among progression of infection, bronchoalveolar cell activation, cellular immune response, and specific isotype patterns. (7729885)
1995
47
Differential correlation between interleukin patterns in disseminated and chronic human paracoccidioidomycosis. (7648715)
1995
48
Histoplasmosis in northwestern Argentina. II: Prevalence of Histoplasmosis capsulati and paracoccidioidomycosis in the population south of Chuscha, Gonzalo and Potrero in the province of Tucuman. (7617013)
1995
49
Plasma amylase levels as a marker of disease severity in an isogenic murine model of paracoccidioidomycosis. (7515958)
1994
50
Treatment of paracoccidioidomycosis, candidiasis, chromomycosis, lobomycosis, and mycetoma with ketoconazole. (6252105)
1980

Genetic Variations for Paracoccidioidomycosis

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Expression for genes affiliated with Paracoccidioidomycosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for genes affiliated with Paracoccidioidomycosis

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Sources:
29KEGG, 53Reactome, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2PDCD1, ICOS
2
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10.2TNFRSF1A, FASLG
3
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10.0IL10, FASLG, TNFRSF1A
410.0TLR4, MYD88, CXCL10
510.0FASLG, MYD88, IL10
610.0IL10, MYD88, TLR4
710.0IL10, MYD88, TLR4
8
Hide members
10.0IL5, CTLA4, FASLG
910.0MYD88, TNFRSF1A, TLR4
1010.0MYD88, TNFRSF1A, TLR4
1110.0HSPD1, TLR4, MYD88
1210.0HSPD1, FASLG, IL5
1310.0IL5, CD28, TNFRSF1A
1410.0CD28, CTLA4, TLR4
15
Immune response Bacterial infections in normal airways
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9.9MYD88, FASLG, TLR4
16
Hide members
9.9ICOS, PDCD1, CTLA4, CD28
17
Hide members
9.8CD28, CXCL10, IL12RB2, IL5
18
Hide members
9.8TLR4, TNFRSF1A, FASLG, MYD88
199.8TLR4, TNFRSF1A, MYD88, CD28
20
Hide members
9.8IL10, IL12RB2, CD28, TLR4
219.8HSPD1, TLR4, TNFRSF1A, MYD88, IL10
22
Hide members
9.7ICOS, PDCD1, CTLA4, CD28, IL5
23
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9.6TLR4, TNFRSF1A, MYD88, IL12RB2, IL10, IL5
24
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9.5TLR4, TNFRSF1A, FASLG, MYD88, CD28, CXCL10
25
Hide members
9.4TLR4, TNFRSF1A, FASLG, MYD88, CXCL10, CXCL9
26
Hide members
9.4TNFRSF1A, CD28, CXCL10, CXCL9, IL12RB2, IL10
27
Hide members
9.3TLR4, ICOS, PDCD1, CTLA4, MYD88, CD28
28
Hide members
9.1IL5, HSPD1, ICOS, TNFRSF1A, FASLG, CTLA4
29
Hide members
9.1TLR4, TNFRSF1A, FASLG, CD28, CXCL10, CXCL9
30
Hide members
9.0TLR4, TNFRSF1A, MYD88, CD28, CXCL10, CXCL9

Compounds for genes affiliated with Paracoccidioidomycosis

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1cyclosporin a44 28 5912.6CTLA4, CD28
2rantes4410.4TLR4, TNFRSF1A, FASLG
3glucose4410.4GLO1, FASLG, TPI1
4indomethacin44 59 28 1113.4GLO1, IL5, HSPD1
5infliximab44 49 1112.3IL10, TLR4, TNFRSF1A, CXCL10
6endotoxin4410.3TNFRSF1A, HSPD1, FASLG, MYD88
7cycloheximide4410.3HSPD1, CXCL10, FASLG
8aspartate4410.3FASLG, G6PD, HSPD1, TPI1
9glutamate4410.3TPI1, GLO1, TNFRSF1A, HSPD1
10con a4410.2IL5, IL10, CTLA4, CD28
11polyinosinic-polycytidylic acid4410.2IL5, IL10, CXCL10, TLR4
12imiquimod44 28 59 1113.2FASLG, IL10, IL5, TLR4
13oxygen44 2411.2CD28, TNFRSF1A, MYD88
14thalidomide44 49 59 1113.1TNFRSF1A, FASLG, CTLA4, IL5, IL10
15manganese superoxide4410.1GSR, TPI1, FASLG, TNFRSF1A, HSPD1
16tarc4410.1IL10, IL5, CXCL10, CXCL9
17glatiramer acetate44 1111.1CTLA4, IL10, IL5
18ifn-alpha4410.1FASLG, TLR4, CXCL10, CXCL9, IL10
19dexamethasone44 49 28 1113.1CXCL9, CTLA4, FASLG, TLR4, IL5
20h2o24410.1G6PD, FASLG, TNFRSF1A, HSPD1
21allergens4410.0TLR4, PDCD1, CTLA4, CXCL10, IL10, IL5
22ivig4410.0IL10, TNFRSF1A, IL5, FASLG
23il 104410.0CXCL9, IL10, IL5, TLR4, CXCL10, CTLA4
24chloroquine44 2 49 28 1114.0G6PD, TNFRSF1A, CXCL10, IL10, GSR, TLR4
25tgf beta14410.0IL10, TNFRSF1A, FASLG, CTLA4, TLR4
26ccl344 2811.0CXCL10, TLR4, CXCL9, IL10
27methylglyoxal44 2810.9GLO1, GSR, TPI1
28glyceraldehyde 3-phosphate449.9G6PD, HSPD1, TLR4, GLO1, TPI1, GSR
29methotrexate44 49 1111.9FASLG, TNFRSF1A, CTLA4, GLO1, IL5, GSR
30cyclophosphamide44 49 1111.9FASLG, G6PD, IL10, GSR, CXCL9
31n acetylcysteine449.8G6PD, FASLG, TNFRSF1A, GSR, HSPD1, TLR4
32tacrolimus44 49 1111.8CTLA4, CD28, CXCL10, IL10, IL5, FASLG
33ionomycin449.8IL10, IL5, CXCL9, CD28, CTLA4, FASLG
34superoxide44 2410.8TPI1, HSPD1, GSR, GLO1, G6PD, TNFRSF1A
35doxorubicin44 49 1111.8TNFRSF1A, HSPD1, GSR, GLO1, G6PD, FASLG
36ly294002449.7CTLA4, IL5, IL10, FASLG, TLR4, MYD88
37lactate449.7G6PD, GLO1, TPI1, HSPD1, FASLG, GSR
38creatinine449.7GLO1, HSPD1, TNFRSF1A, GSR, G6PD, TPI1
39adenylate449.7CXCL10, GLO1, IL5, FASLG, G6PD, TPI1
40alanine449.6FASLG, TNFRSF1A, TLR4, HSPD1, CXCL10, GLO1
41vegf449.6CXCL9, HSPD1, TNFRSF1A, FASLG, CXCL10, IL10
42guanidine hydrochloride449.6GSR, TPI1, G6PD, HSPD1
43nitric oxide44 11 2411.6TLR4, FASLG, MYD88, IL10, CXCL9, GLO1
44cholesterol44 28 11 2412.6CXCL10, HSPD1, TNFRSF1A, FASLG, TLR4, CTLA4
45atp44 2810.5MYD88, TLR4, HSPD1, TNFRSF1A, CXCL9, CXCL10
46phosphatidylinositol449.5HSPD1, TLR4, CD28, TNFRSF1A, FASLG, CXCL9
47genistein44 28 59 2 11 2414.4CXCL10, CD28, TLR4, FASLG, IL5, GSR
48cysteine449.3TNFRSF1A, GSR, IL5, CD28, GLO1, CTLA4
49lipid449.2GLO1, CXCL10, TPI1, GSR, CD28, MYD88
50tyrosine448.7TPI1, IL12RB2, CKS1B, HSPD1, CXCL9, PDCD1

GO Terms for genes affiliated with Paracoccidioidomycosis

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16Gene Ontology
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Cellular components related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor complexGO:04669610.2TLR4, HSPD1
2extracellular spaceGO:0056159.3HSPD1, TNFRSF1A, FASLG, CXCL10, CXCL9, IL10
3integral to plasma membraneGO:0058879.1TLR4, ICOS, TNFRSF1A, FASLG, CTLA4, CD28
4external side of plasma membraneGO:0098979.0IL12RB2, TLR4, ICOS, PDCD1, FASLG, CTLA4

Biological processes related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.3IL10, TLR4
2negative regulation of interleukin-6 productionGO:03271510.3TLR4, TNFRSF1A, IL10
3positive regulation of interferon-gamma productionGO:03272910.3IL12RB2, TLR4, HSPD1
4interferon-gamma productionGO:03260910.3TLR4, IL12RB2
5positive regulation of interleukin-6 productionGO:03275510.3HSPD1, TLR4, MYD88
6negative regulation of B cell proliferationGO:03088910.2IL10, CTLA4
7glutathione metabolic processGO:00674910.2G6PD, GLO1, GSR
8cellular response to mechanical stimulusGO:07126010.2MYD88, TNFRSF1A, TLR4
9T cell costimulationGO:03129510.2CD28, CTLA4, PDCD1, ICOS
10positive regulation of interferon-alpha productionGO:03272710.2HSPD1, TLR4
11pentose-phosphate shuntGO:00609810.1G6PD, TPI1
12cell surface receptor signaling pathwayGO:00716610.1MYD88, CD28, CXCL10, IL12RB2
13MyD88-dependent toll-like receptor signaling pathwayGO:00275510.1HSPD1, TLR4, MYD88
14positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.1MYD88, FASLG, TNFRSF1A, TLR4
15response to lipopolysaccharideGO:03249610.0TLR4, TNFRSF1A, FASLG, CXCL10, IL12RB2
16cell-cell signalingGO:00726710.0IL10, CXCL9, CXCL10, FASLG
17B cell proliferationGO:0421009.9IL10, HSPD1
18inflammatory responseGO:0069549.9TNFRSF1A, MYD88, CXCL10, CXCL9, IL10, IL5
19immune responseGO:0069559.7IL5, CXCL9, CXCL10, CTLA4, FASLG, ICOS

Molecular functions related to Paracoccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.8IL5, IL10, CXCL9, FASLG
2protein bindingGO:0055157.8TPI1, HSPD1, CKS1B, EXOSC3, TLR4, PDCD1

Products for genes affiliated with Paracoccidioidomycosis

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Sources for Paracoccidioidomycosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet