Paraganglioma malady

Wikipedia: A paraganglioma is a rare neuroendocrine neoplasm that may develop at various body sites (including the...⁴⁴ more...

MalaCards: Paraganglioma, also known as paragangliomas, is related to hereditary paraganglioma-pheochromocytoma syndromes and paraganglioma and gastric stromal sarcoma. An important gene associated with Paraganglioma is SDHAF2 (succinate dehydrogenase complex assembly factor 2), and among its related pathways are Citric acid cycle (TCA cycle) and Citrate cycle (TCA cycle). The compounds mibg and threonine have been mentioned in the context of this disorder. Affiliated tissues include lung, spinal cord and ovary, and related mouse phenotypes are respiratory system and craniofacial.

paraganglioma 7 32 43 paragangliomas 7

Disease types for paraganglioma family:

paragangliomas 1	paragangliomas 2
paragangliomas 3	paragangliomas 4

Diseases related to paraganglioma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 814)

id	Related Disease	Score	Top Affiliating Genes
1	hereditary paraganglioma-pheochromocytoma syndromes	35.1	RET, SDHB, CHGA
2	paraganglioma and gastric stromal sarcoma	32.2	SDHB, SDHC, SDHD
3	carotid body tumor	31.1	SDHB, SDHC, SDHD
4	carney triad	31.0	KIT, SDHA, SDHB, SDHC, SDHD, ACTC1
5	chondroma	29.6	KIT, SDHA, SDHB, SDHC, SDHD, S100A1
6	erythrocytosis	29.4	REN, VHL, EGLN1, HIF1A, EPAS1, EPO
7	mitochondrial complex ii deficiency	28.4	SDHA, SDHB, SDHC, SDHD
8	merkel cell carcinoma	27.9	NCAM1, KIT, CHGA, ENO2, SST, KRT20
9	somatostatinoma	27.8	VIP, CHGA, MEN1, ENO2, CALCA, SST
10	thyroid cancer	27.6	RET, LGALS3, CALCA, KRT20, KRT19, TG
11	neuroendocrine carcinoma	27.1	NCAM1, KIT, SCG2, CHGA, S100B, ASCL1
12	von hippel-lindau disease	25.4	REN, RET, KIT, VIM, VIP, VHL
13	adrenocortical tumor	25.3	RET, VHL, SDHB, SDHC, SDHD, CHGB
14	neuroendocrine tumor	25.3	NCAM1, RET, VIP, SDHD, SCG2, CHGB
15	duodenitis	24.9	KIT, PCNA, VIP, BCL2, LGALS3, CHGA
16	ganglioneuroma	24.8	NCAM1, RET, VIP, VHL, SCG2, CHGA
17	conjunctivitis	24.2	VIM, BCL2, SDHD, CDKN2A, FGF2, CCND1
18	multiple endocrine neoplasia	24.2	RET, VIP, VHL, SDHB, SDHC, SDHD
19	mediastinitis	24.2	KIT, PCNA, VIM, SDHB, SDHD, S100A1
20	pheochromocytoma	23.8	NCAM1, REN, RET, KIT, VIP, BSG
21	gastrointestinal stromal tumor	22.8	NCAM1, KIT, PCNA, VIM, BCL2, SDHA
22	renal cell carcinoma	22.6	RET, KIT, PCNA, VIM, BSG, VHL
23	carcinoid tumors	22.0	NCAM1, RET, PCNA, VIP, BCL2, SDHD
24	nevus	21.3	KIT, PCNA, VIM, BCL2, S100A1, S100B
25	laryngitis	21.0	PCNA, VIM, BSG, BNIP3, BCL2, SDHC
26	thyroid carcinoma	21.0	RET, PCNA, VIM, BSG, VHL, BCL2
27	nasopharyngitis	18.4	KIT, PCNA, VIM, VHL, BNIP3, LIF
28	hypertension	18.4	NCAM1, REN, RET, KIT, PCNA, VIP
29	hypoxia	18.2	REN, RET, KIT, PCNA, VIP, BSG
30	sarcoma	17.3	NCAM1, REN, RET, KIT, PCNA, VIM
31	cervicitis	17.2	REN, RET, KIT, PCNA, VIM, VIP
32	thyroiditis	16.6	NCAM1, REN, RET, KIT, PCNA, VIM
33	carcinoma	15.0	NCAM1, REN, RET, KIT, PCNA, VIM
34	neuroblastoma	14.3	NCAM1, RET, KIT, PCNA, VIM, VIP
35	familial renal cell carcinoma	14.0	VHL, SDHB, SDHC, SDHD, FH
36	familial medullary thyroid carcinoma	14.0	RET, SDHB, SDHC, SDHD, CALCA
37	peripheral neuroblastoma	14.0	CHGA, S100B, SYP
38	hereditary leiomyomatosis and renal cell cancer	14.0	SDHB, FH, HIF1A
39	gastric small cell carcinoma	14.0	NCAM1, CHGA, ENO2, SYP
40	melanoma	14.0	NCAM1, RET, KIT, PCNA, VIM, VIP
41	supratentorial neoplasm	14.0	CHGA, ENO2, SYP
42	papillary ependymoma	14.0	S100B, GFAP, SYP
43	pineal gland cancer	14.0	ENO2, GFAP, SYP
44	central neurocytoma	13.9	CHGA, GFAP, SYP
45	meningeal melanocytoma	13.9	S100B, MLANA, ENO2
46	familial isolated hyperparathyroidism	13.9	RET, MEN1, GAST
47	apudoma	13.9	CALCA, SST, GAST
48	dysembryoplastic neuroepithelial tumor	13.9	CHGA, S100B, GFAP, SYP
49	prostate small cell carcinoma	13.9	NCAM1, CHGA, ENO2, CALCA, GAST
50	atrophic gastritis	13.9	CHGA, MEN1, SST, GAST

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to paraganglioma:

²²

MGI Mouse Phenotypes related to paraganglioma:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.1	PRKAR1A, EPAS1, TH, NF1, RET, LIF
2	craniofacial phenotype	MP:0005382	9.9	PTPRF, KIT, ASCL1, MEN1, NF1, EDNRA
3	endocrine/exocrine gland phenotype	MP:0005379	9.9	RET, ASCL1, FGFR1, MEN1, PTPRF, NRTN
4	embryogenesis phenotype	MP:0005380	8.7	RET, KIT, VIM, SDHD, VHL, FGFR1
5	liver/biliary system phenotype	MP:0005370	8.3	MEN1, IL6, NF1, EGFR, LIF, HIF1A
6	reproductive system phenotype	MP:0005389	8.0	KRT19, PRKAR1A, CPE, ADCYAP1, LIF, NKX2-1
7	no phenotypic analysis	MP:0003012	7.7	ASCL1, KRT19, PCNA, FGFR1, IGF2, SST
8	renal/urinary system phenotype	MP:0005367	7.6	RET, KIT, EDNRA, BCL2, REN, FH
9	pigmentation phenotype	MP:0001186	7.4	PTEN, KIT, BCL2, CDKN2A, ASCL1, POMC
10	normal phenotype	MP:0002873	7.2	REN, NF1, EDNRA, GFAP, TH, SYP
11	hematopoietic system phenotype	MP:0005397	7.2	EGLN1, BCL2, LGALS3, NF1, EPO, EPAS1
12	adipose tissue phenotype	MP:0005375	7.2	GFRA2, ADCYAP1, CPE, NPY, POMC, PRKAR1A
13	hearing/vestibular/ear phenotype	MP:0005377	7.1	BCL2, FGF2, FGFR1, MBP, CALCA, NTRK1
14	integument phenotype	MP:0010771	6.9	KIT, VHL, EGLN1, GFRA2, TH, DBH
15	immune system phenotype	MP:0005387	6.3	PTPRF, REN, MBP, MEN1, KIT, VIM
16	digestive/alimentary phenotype	MP:0005381	6.1	LGALS3, CDKN2A, FGFR1, MEN1, IGF2, PTEN
17	tumorigenesis	MP:0002006	5.8	KIT, RET, POMC, VHL, SDHD, CDKN2A
18	skeleton phenotype	MP:0005390	5.7	FGFR1, FGF2, MMP2, CDKN2A, LGALS3, LIF
19	behavior/neurological phenotype	MP:0005386	5.7	NCAM1, REN, KIT, VIM, VIP, PTPRF
20	mortality/aging	MP:0010768	5.6	NF1, GAST, EPAS1, KRT19, EDN3, EGFR
21	muscle phenotype	MP:0005369	4.4	REN, RET, KIT, VIM, VHL, BNIP3
22	nervous system phenotype	MP:0003631	4.1	REN, KIT, LIF, SDHD, LGALS3, CHGB
23	vision/eye phenotype	MP:0005391	4.0	MBP, GFAP, GFRA2, TH, DBH, PRKAR1A
24	cardiovascular system phenotype	MP:0005385	3.1	HIF1A, GFAP, TH, STMN1, DBH, PRKAR1A
25	growth/size phenotype	MP:0005378	3.1	BCL2, CHGA, CDKN2A, MMP2, ASCL1, FGFR1
26	cellular phenotype	MP:0005384	3.0	EPO, KIT, CDKN2A, LGALS3, SDHD, BCL2
27	homeostasis/metabolism phenotype	MP:0005376	1.8	NPY, SLC6A2, CPE, NKX2-1, ADCYAP1, EPAS1

Articles related to paraganglioma:

(show top 50)    (show all 243)

id	Title	Authors	Year	Affiliating Genes
1	Germline mutations of the TMEM127 gene in patients wi th paraganglioma of head and neck and extraadrenal abdominal sites. (21613359)	Neumann H.P.... Eng C.	2011	TMEM127
2	SDHA is a tumor suppressor gene causing paraganglioma. (20484225)	Burnichon N.... Gimenez-Roqueplo A.P.	2010	SDHA
3	Spectrum and prevalence of FP/TMEM127 gene mutations in pheochromocytomas and paragangliomas. (21156949)	Yao L.... Dahia P.L.	2010	TMEM127
4	Mutation analysis of the SDHB and SDHD genes in pheoc hromocytomas and paragangliomas: identification of a novel nonsense mutation (Q 168X) in the SDHB gene. (20505258)	Oishi Y.... Shimizu C.	2010	SDHB, SDHD
5	Clinical predictors for germline mutations in head and neck paraganglioma patients: cost reduction strategy in genetic diagnostic process as fall-out. (19351833)	Neumann H.P.... Eng C.	2009	SDHC
6	An immunohistochemical procedure to detect patients w ith paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis. (19576851)	van Nederveen F.H.... Dinjens W.N.	2009	SDHB, SDHC, SDHD
7	Malignant paraganglioma associated with succinate deh ydrogenase subunit B in an 8-year-old child: the age of first screening? (19189136)	Prodanov T.... Pacak K.	2009	SDHB
8	Clinical aspects of SDHx-related pheochromocytoma and paraganglioma. (19190077)	Timmers H.J.... Pacak K.	2009	SDHB
9	Pheochromocytomas and extra-adrenal paragangliomas de tected by screening in patients with SDHD-associated head-and-neck paragangliom as. (19289533)	Havekes B.... Corssmit E.P.	2009	SDHD
10	Ischemic stroke and rhabdomyolysis in a 15-year-old g irl with paraganglioma due to an SDHB exon 6 (Q214X) mutation. (19694205)	Kim M.S.... Quintos J.B.	2009	SDHB
11	The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gas tric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clini cal implications. (19522824)	Stratakis C.A.... Carney J.A.	2009	SDHA, SDHC, SDHD
12	SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. (19628817)	Hao H.-X.... Rutter J.	2009	SDHA, SDHAF2
13	Sporadic paraganglioma. (18224469)	Lee J.A.... Duh Q.Y.	2008	SDHB, SDHD
14	Stathmin expression in pheochromocytomas, paragangliomas, and in other endocrine tumors. (18461287)	Sadow P.M.... Lloyd R.V.	2008	STMN1
15	Mutations associated with succinate dehydrogenase D-related malignant paragangliomas. (17973943)	Timmers H.J.... Gimenez-Roqueplo A.P.	2008	SDHB, SDHC, SDHD
16	Malignant paraganglioma caused by a novel germline mutation of the succinate dehydrogenase D-gene--a case report. (18213727)	Papaspyrou K.... Helling K.	2008	SDHB
17	Uncommon clinical presentations of pheochromocytoma and paraganglioma in two different patients affected by two distinct novel VHL germline mutations. (18031321)	Ercolino T.... Mannelli M.	2008	SDHC
18	Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma. (17639058)	Korpershoek E.... de Krijger R.R.	2007	RET, VHL, SDHB
19	Paraganglioma: report of a rare case with ovarian involvement. (17633808)	Bacha D.... Ben Romdhane K.	2007	KRT7
20	Germline mutations in PTEN and SDHC in a woman with epithelial thyroid cancer and carotid paraganglioma. (17898811)	Zbuk K.M.... Eng C.	2007	PTEN, SDHB, SDHC
21	High frequency of germline succinate dehydrogenase mutations in sporadic cervical paragangliomas in northern Spain: mitochondrial succinate dehydrogenase structure-function relationships and clinical-pathological correlations. (17848412)	Lima J.... Garcia-Rostan G.	2007	SDHB, SDHC, SDHD
22	Paraganglioma syndrome: SDHB, SDHC, and SDHD mutations in head and neck paragangliomas. (17102086)	Schiavi F.... Opocher G.	2006	SDHB, SDHC, SDHD
23	Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma. (16405730)	Bayley J.P.... Taschner P.E.	2006	SDHB, SDHC, SDHD
24	The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency. (16288654)	Bayley J.P.... Taschner P.E.	2005	SDHB, SDHA, SDHC
25	Are somatostatin analogs therapeutic alternatives in the management of head and neck paragangliomas? (16094109)	Duet M.... Tran Ba Huy P.	2005	SST
26	Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. (15328326)	Neumann H.P.H.... Eng C.	2004	SDHB, SDHD
27	Paraganglioma in the area of the head and neck. A review of molecular genetic research (14740109)	Braun S.... Kupka S.	2004	SDHB, SDHD
28	An Alu-mediated partial SDHC deletion causes familial and sporadic paraganglioma. (15342702)	Baysal B.E.... Ferrell R.E.	2004	SDHC
29	The prevalence of SDHB, SDHC, and SDHD mutations in patients with head and neck paraganglioma and association of mutations with clinical features. (15235042)	Badenhop R.F.... Schofield P.R.	2004	SDHB, SDHC, SDHD
30	A thyroid nodule revealing a paraganglioma in a patient with a new germline mutation in the succinate dehydrogenase B gene. (15476441)	Zantour B.... Bertagna X.	2004	SDHB
31	Primary paraganglioma of the thyroid gland. (15636436)	Corrado S.... Papi G.	2004	ENO2, SYP, TG
32	Autosomal dominant malignant and catecholamine-producing paraganglioma caused by a splice donor site mutation in SDHC. (12658451)	Niemann S.... Lohse P.	2003	SDHC
33	Hereditary paraganglioma due to the SDHD M1I mutation in a second Chinese family: a founder effect? (12782822)	Lee S.C.... Taschner P.E.	2003	SDHB, SDHC, SDHD
34	Galanin immunoreactivity in paragangliomas but not in carcinoid tumors. (12966352)	Tadros T.S.... Gal A.A.	2003	GAL
35	Loss of heterozygosity on the short arm of chromosome 1 in pheochromocytoma and abdominal paraganglioma. (12045857)	Edstrom Elder E.... Larsson C.	2002	PTPRF
36	Pulmonary gangliocytic paraganglioma: case report and comparative immunohistochemical study of related neuroendocrine neoplasms. (11342785)	Hironaka M.... Funata N.	2001	S100B, SYP, CHGA
37	Novel mutations and the emergence of a common mutation in the SDHD gene causing familial paraganglioma. (11343322)	Milunsky J.M.... Milunsky A.	2001	SDHD
38	Germline SDHD mutation in paraganglioma of the spinal cord. (11526495)	Masuoka J.... Ohgaki H.	2001	SDHD
39	Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. (11404820)	Astuti D.... Maher E.R.	2001	RET, NF1, SDHB
40	Sustentacular cells in sporadic paraganglioma-like medullary thyroid carcinoma: report of a case with diagnostic and histogenetic considerations. (10674273)	Magro G.... Grasso S.	2000	S100B, GFAP
41	Paraganglioma of the urinary bladder: can biologic potential be predicted? (10679654)	Cheng L.... Bostwick D.G.	2000	S100B
42	Duodenal gangliocytic paraganglioma as a radiological moving defect. (11155013)	Kotsis T.... Mallas E.	2000	SST, GAST
43	Retroperitoneal non-secreting paraganglioma (10209712)	Crozier F.... Bartoli J.M.	1999	CHGA
44	Duodenal gangliocytic paraganglioma presenting as an ampullary tumor. (8968869)	Evans J.D.... Neoptolemos J.P.	1996	SST
45	A patient with malignant paraganglioma that simultaneously produces adrenocorticotropic hormone and interleukin-6. (7914826)	Omura M.... Nishikawa T.	1994	IL6
46	New histopathologic data of prognostic value in extra-adrenal paragangliomas. Study of 9 cases (8105157)	GarcA-a Rojo M.... PatrA^n Romero M.	1993	PCNA, CHGA
47	A comparative immunohistochemical study of phaeochromocytomas and paragangliomas. (8358154)	Fraga M.... Forteza J.	1993	S100B, ENO2, GFAP
48	Catecholamine synthesizing enzymes in 70 cases of functioning and non-functioning phaeochromocytoma and extra-adrenal paraganglioma. (1353277)	Kimura N.... Nagura H.	1992	TH, DDC, DBH
49	In vitro and in vivo detection of somatostatin receptors in pheochromocytomas and paragangliomas. (1349024)	Reubi J.C.... Lamberts S.	1992	SST
50	Medullary carcinoma of the thyroid gland: an encapsulated variant resembling the hyalinizing trabecular (paraganglioma-like) adenoma of thyroid. (2235983)	Huss L.J.... Mendelsohn G.	1990	CALCA, TG

Genes related to paraganglioma according to GeneCards:

(show top 50)    (show all 90)

id	Symbol	Description	Score	GeneCards Section Context
1	SDHAF2	succinate dehydrogenase complex assembly factor 2	11.1	Publications, Aliases & Descriptions, Orthologs, Summaries
2	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.1	Publications, Summaries
3	SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	11.1	Publications, Summaries
4	SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	11.1	Publications, Orthologs, Summaries
5	TIMM8B	translocase of inner mitochondrial membrane 8 homolog B (yeast)	11.0	Summaries
6	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0	Publications
7	RET	ret proto-oncogene	11.0	Publications
8	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0	Publications
9	SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	11.0	Publications
10	FH	fumarate hydratase	11.0	Publications
11	IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	11.0	Publications
12	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
13	CHGB	chromogranin B (secretogranin 1)	11.0	Publications
14	SCG2	secretogranin II	11.0	Publications
15	SYP	synaptophysin	11.0	Publications
16	PNMT	phenylethanolamine N-methyltransferase	11.0	Publications
17	MEN1	multiple endocrine neoplasia I	11.0	Publications
18	S100B	S100 calcium binding protein B	11.0	Publications
19	SSTR2	somatostatin receptor 2	11.0	Publications
20	GAL	galanin prepropeptide	11.0	Publications
21	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0	Publications
22	ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	11.0	Publications
23	S100A1	S100 calcium binding protein A1	11.0
24	PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	11.0
25	SST	somatostatin	11.0	Publications
26	GRP	gastrin-releasing peptide	11.0	Publications
27	NF1	neurofibromin 1	11.0	Publications
28	GFAP	glial fibrillary acidic protein	11.0	Publications
29	TG	thyroglobulin	11.0	Publications
30	TH	tyrosine hydroxylase	11.0	Publications
31	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
32	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
33	GAST	gastrin	11.0	Publications
34	NCAM1	neural cell adhesion molecule 1	11.0	Publications
35	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
36	ENSG00000256591		11.0	Orthologs
37	TMEM127	transmembrane protein 127	11.0	Publications
38	NRTN	neurturin	11.0	Publications
39	IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	11.0	Publications
40	ASCL1	achaete-scute complex homolog 1 (Drosophila)	11.0	Publications
41	B3GAT1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	11.0	Publications
42	MLANA	melan-A	11.0	Publications
43	BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	11.0	Publications
44	NKX2-1	NK2 homeobox 1	11.0	Publications
45	EDN3	endothelin 3	11.0	Publications
46	EGLN1	egl nine homolog 1 (C. elegans)	11.0	Publications
47	GFRA2	GDNF family receptor alpha 2	11.0	Publications
48	STMN1	stathmin 1	11.0	Publications
49	PTPRF	protein tyrosine phosphatase, receptor type, F	11.0	Publications
50	PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha	11.0	Publications

Pathways related to paraganglioma according to GeneDecks:

(show top 50)    (show all 70)

id	Pathway	Score	Top Affiliating Genes
1	Citric acid cycle (TCA cycle)38	10.8	FH, SDHD, SDHC, SDHB, SDHA, IDH2
2	Citrate cycle (TCA cycle)20	10.7	IDH2, IDH1, FH, SDHD, SDHA, SDHB
3	Actin-Based Motility by Rho Family GTPases36	10.6	NTRK1
4	Cellular responses to stress38	9.9	EPAS1, EPO, EGLN1, VHL
5	14-3-3 Induced Intracellular Signaling36	9.7	NTRK2, NTRK3, NTRK1, FGF2, NTF3
6	Neuroscience3	9.6	RET, NCAM1, NTRK2, DBH, SYP, GFAP
7	CREB Pathway36	9.6	NTRK3, NTF3, FGFR1, IGF2, KIT, NTRK2
8	Angiogenesis3	9.4	FGF2, FGFR1, REN, HIF1A, TYMP, MMP2
9	Rac1 Pathway36	9.2	NTRK3, FGF2, IL6, FGFR1, NTRK1, NTF3
10	Akt Signaling36	9.1	IL6, NTRK3, NTF3, CCND1, FGFR1, LIF
11	Breast Cancer Regulation by Stathmin136	8.9	EGFR, PPP2R1B, NTRK3, NTF3, NTRK1, NTRK2
12	Paxillin Interactions36	8.7	KIT, FGF2, EGFR, FGFR1, NTF3, NTRK1
13	ERK Signaling36	8.7	PRKAR1A, KIT, IGF2, NTRK3, PPP2R1B, EGFR
14	eNOS Signaling36	8.5	NTRK2, EGFR, PRKAR1A, KIT, NTRK3, NTRK1
15	Endothelin-1 Signaling Pathway36	8.5	NTRK2, NTRK3, EDNRA, EGFR, NTRK1, KIT
16	GSK3 Signaling36	8.4	FGFR1, NTRK2, EGFR, FGF2, KIT, IGF2
17	P2Y Receptor Signaling36	8.4	FGFR1, FGF2, KIT, NTRK1, NTRK2, NTRK3
18	Ras Pathway36	8.3	FGF2, EGFR, NTRK3, NTRK2, NTF3, IGF2
19	ERK5 Signaling36	8.2	KIT, FGFR1, IGF2, NTF3, NTRK1, NTRK2
20	Activation of PKA through GPCR36	8.1	KIT, NTRK3, NTRK2, NTRK1, IGF2, IL6
21	PTEN Pathway36	8.1	FGF2, KIT, FGFR1, NTF3, NTRK1, NTRK2
22	JNK Pathway36	8.1	BCL2, FGF2, IL6, NTF3, KIT, NTRK1
23	ILK Signaling36	8.0	IGF2, FGFR1, EGFR, HIF1A, FGF2, PPP2R1B
24	Apoptotic Pathways in Synovial Fibroblasts36	7.8	EGFR, KIT, FGF2, FGFR1, IL6, IGF2
25	PPAR Pathway36	7.8	EGFR, NTRK3, NTRK2, NTRK1, NTF3, IGF2
26	Telomerase Components in Cell Signaling36	7.8	NTRK3, EGFR, PPP2R1B, KIT, NTRK2, NTRK1
27	eIF2 Pathway36	7.8	KIT, FGF2, FGFR1, IL6, IGF2, NTF3
28	Nanog in Mammalian ESC Pluripotency36	7.8	FGF2, FGFR1, IL6, NTRK1, IGF2, KIT
29	p70S6K Signaling36	7.8	NTRK2, NTF3, EGFR, FGF2, FGFR1, IL6
30	Nuclear Receptor Activation by Vitamin-A36	7.7	NTRK3, PRKAR1A, NTRK2, IGF2, NTF3, NTRK1
31	Activation of PKC through GPCR36	7.7	NTRK3, EGFR, IL6, FGF2, FGFR1, KIT
32	GPCR Pathway36	7.6	IL6, IGF2, FGF2, KIT, NTRK2, NTRK1
33	Rap1 Pathway36	7.6	PRKAR1A, EGFR, NTRK3, FGFR1, IL6, IGF2
34	Signaling Involved in Cardiac Hypertrophy36	7.5	NTRK1, IL6, FGFR1, LIF, NTRK2, EDNRA
35	NFAT in Immune Response36	7.5	FGF2, NTRK1, KIT, EGFR, NTRK3, NTRK2
36	Pathways in cancer20	7.4	EGFR, EPAS1, HIF1A, NTRK1, PTEN, CCND1
37	Renin-Angiotensin Pathway36	7.4	EGFR, NTRK2, NTRK3, NTRK1, KIT, NTF3
38	DHA Signaling36	7.2	FGFR1, KIT, BCL2, FGF2, IL6, NTRK3
39	PAK Pathway36	7.0	NTRK1, FGFR1, NTRK2, IL6, NTF3, NTRK3
40	Antioxidant Action of Vitamin-C36	6.9	NTF3, NTRK2, BCL2, NTRK3, LIF, NTRK1
41	p53 Mediated Apoptosis36	6.8	NTRK1, PTEN, NTRK3, NTRK2, NTF3, IGF2
42	JAK-STAT Pathway36	6.8	BCL2, EPO, EGFR, NTRK3, NTRK2, KIT
43	p38 Signaling36	6.7	BCL2, EGFR, NTRK3, NTRK2, NTRK1, NTF3
44	Mitochondrial Apoptosis36	6.7	IGF2, FGFR1, NTF3, CDKN2A, KIT, FGF2
45	Cellular Apoptosis Pathway36	6.7	IL6, KIT, BCL2, CDKN2A, FGF2, FGFR1
46	Estrogen Pathway36	6.6	BCL2, FGF2, FGFR1, NTRK1, PRKAR1A, EGFR
47	Rho Family GTPases36	6.6	IL6, EGFR, BCL2, VIM, FGF2, FGFR1
48	MAPK Signaling36	6.6	EGFR, KIT, BCL2, FGF2, FGFR1, PRKAR1A
49	Molecular Mechanisms of Cancer36	6.1	FGFR1, CDKN2A, CCND1, IGF2, PTEN, NTF3
50	Pancreatic Adenocarcinoma36	6.0	KIT, BCL2, CDKN2A, IL6, FGF2, NTF3

Compounds related to paraganglioma according to GeneDecks:

(show top 50)    (show all 312)

id	Compound	Score	Top Affiliating Genes
1	mibg32	10.7	SDHB, SDHD, ENO2
2	threonine32	9.7	RET, FGFR1, PTPRF, NTRK1, NTRK3, STMN1
3	b 72332	9.4	PCNA, VIM, CHGA, S100A1, S100B, CEACAM3
4	ly29400232	9.3	RET, VHL, MMP2, FGF2, IL6, CCND1
5	h2o232	9.1	VIP, LIF, SDHB, LGALS3, MBP, PTPRF
6	gnrh32	9.1	NCAM1, VIM, SCG2, FGFR1, GRP, NTRK1
7	epinephrine32 9 18 9	11.9	REN, VIP, SDHB, CHGA, MMP2, GRP
8	glucose32	8.9	KIT, VHL, BNIP3, SCG2, S100B, FH
9	choline32 9 18 9	11.8	RET, VIM, VIP, LIF, S100B, GRP
10	octreotide32 42 9 9	11.7	VIP, CHGA, MMP2, GRP, ENO2, IGF2
11	catecholamine32	8.6	REN, RET, VIM, VIP, SDHB, SDHD
12	corticosterone32 18	9.5	VIP, LIF, FGF2, GRP, MBP, IGF2
13	agar32	8.4	RET, VIM, CDKN2A, FGF2, FGFR1, GRP
14	ribonucleic acid32	8.4	RET, KIT, LIF, CHGA, MMP2, FGFR1
15	iron32 18	9.4	VIM, VHL, SDHA, SDHB, SDHC, SDHD
16	glutamine32	8.3	NCAM1, KIT, PCNA, VIM, VIP, LGALS3
17	arginine32	8.3	REN, RET, VIP, LIF, SDHB, CHGA
18	histamine32 18	9.3	NCAM1, KIT, PCNA, VIM, VIP, SCG2
19	5-hydroxytryptamine32	8.3	VIM, VIP, SCG2, CHGA, FGF2, GRP
20	gaba32 42	9.3	NCAM1, VIM, VIP, CHGA, S100B, GRP
21	glycogen32 18	9.2	KIT, VIM, VHL, LIF, SDHB, LGALS3
22	pge232	8.0	REN, VIP, LIF, FGF2, GRP, SST
23	acetylcholine32 9 18 9	11.0	NCAM1, VIM, VIP, LIF, SCG2, CHGA
24	hydrocortisone32 9 9	9.5	REN, VIM, LIF, MMP2, FGF2, GRP
25	glutamate32	7.4	NCAM1, PCNA, VIM, VIP, BSG, SDHB
26	forskolin32 42 9 9	10.4	REN, VIM, VIP, LIF, SCG2, CHGA
27	oxygen32 18	8.4	LIF, BCL2, SDHA, SDHB, SDHC, SDHD
28	aspartate32	7.4	RET, PCNA, VIM, VIP, SDHB, S100B
29	creatinine32	7.2	NCAM1, REN, PCNA, SDHB, CHGA, S100B
30	matrigel32	7.2	NCAM1, VIM, BSG, LIF, LGALS3, CHGA
31	formaldehyde32 18	8.0	KIT, PCNA, VIM, LGALS3, CHGA, S100B
32	calcium32 9 18 9	10.0	REN, KIT, VIP, VHL, BNIP3, LIF
33	cysteine32	7.0	PCNA, LIF, SDHB, SCG2, LGALS3, S100A1
34	norepinephrine32 9 18 9	9.9	REN, VIP, LIF, SDHB, SCG2, CHGB
35	steroid32	6.6	REN, KIT, LIF, SDHC, CHGA, S100B
36	doxorubicin32 34 9 9	9.5	NCAM1, KIT, VIM, BCL2, CEACAM3, CDKN2A
37	lactate32	6.3	NCAM1, KIT, PCNA, VIM, VIP, BSG
38	thymidine32 18	7.3	KIT, PCNA, VIP, LIF, S100B, CEACAM3
39	nitric oxide32 9 18 9	9.3	NCAM1, REN, KIT, VIP, VHL, BNIP3
40	retinoic acid32 42 18	8.1	NCAM1, RET, KIT, LIF, SDHC, LGALS3
41	alanine32	5.9	NCAM1, RET, PCNA, VIP, LGALS3, B3GAT1
42	pd 98,05932	5.9	RET, KIT, LIF, BCL2, MMP2, FGF2
43	estrogen32	5.5	PCNA, VIP, BSG, VHL, BNIP3, LGALS3
44	genistein32 9 18 9	8.5	RET, PCNA, VIM, LIF, BCL2, CDKN2A
45	paclitaxel32 34 9 9	8.2	KIT, PCNA, VIM, BNIP3, LIF, BCL2
46	progesterone32 42 9 18 9	9.2	NCAM1, KIT, PCNA, BSG, LIF, BCL2
47	testosterone32 9 18 9	6.5	NCAM1, RET, KIT, PCNA, VIM, VIP
48	paraffin32	3.4	NCAM1, RET, KIT, PCNA, VIM, LIF
49	serine32	3.2	NCAM1, RET, KIT, VIM, VIP, BSG
50	tyrosine32	2.3	NCAM1, RET, KIT, VIP, BSG, VHL

Cellular components related to paraganglioma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial respiratory chain complex II	GO:005749	10.5	SDHA, SDHD, SDHC, SDHB
2	secretory granule	GO:030141	9.9	POMC, CPE, GAL, CHGA, CHGB, SCG2
3	neuronal cell body	GO:043025	9.4	S100B, ASCL1, MBP, DDC, SST, NTRK2
4	extracellular region	GO:005576	7.2	NCAM1, EDN3, TG, PSG2, DBH, POMC
5	extracellular space	GO:005615	6.7	EPO, NPY, POMC, EGFR, EDN3, SST
6	cytosol	GO:005829	6.6	DDC, EPAS1, PRKAR1A, STMN1, TH, VIM
7	cytoplasm	GO:005737	5.1	ENG, SDHAF2, IDH1, MEN1, FGF2, FH

Biological processes related to paraganglioma according to GeneDecks:

(show all 33)

id	Name	GO ID	Score	Top Affiliating Genes
1	tricarboxylic acid cycle	GO:006099	10.7	SDHB, SDHA, SDHC, SDHD, FH, IDH1
2	response to pain	GO:048265	10.5	DBH, CALCA, RET, SLC6A2
3	catecholamine biosynthetic process	GO:042423	10.5	TH, DDC, PNMT, DBH
4	neural crest cell migration	GO:001755	10.5	NRTN, EDN3, RET
5	feeding behavior	GO:007631	10.3	NPY, NKX2-1, CALCA, NTRK2, GAL
6	cerebral cortex development	GO:021987	10.2	HIF1A, NPY, NF1, ASCL1, NTRK2
7	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061418	10.2	EPO, HIF1A, EGLN1, VHL, EPAS1
8	mechanoreceptor differentiation	GO:042490	10.2	NTF3, NTRK1, NTRK2
9	central nervous system neuron development	GO:021954	10.1	FGFR1, NPY, NTRK2, ASCL1
10	activation of adenylate cyclase activity	GO:007190	10.1	EDNRA, NTRK1, CALCA, NTRK2, ADCYAP1
11	neuropeptide signaling pathway	GO:007218	10.1	NPY, GRP, CALCA, POMC, GAL, CPE
12	cellular response to stress	GO:033554	10.1	HIF1A, EGLN1, KRT20, VHL, EPAS1, EPO
13	positive regulation of phospholipase C activity	GO:010863	10.1	KIT, FGF2, FGFR1
14	cellular response to hypoxia	GO:071456	10.1	VHL, EPAS1, HIF1A, EGLN1, BNIP3, EPO
15	intermediate filament organization	GO:045109	10.0	GFAP, VIM, KRT20
16	transmembrane receptor protein tyrosine kinase signaling pathway	GO:007169	10.0	NTRK3, NTRK1, NTRK2, NRTN, GFRA2, ADCYAP1
17	positive regulation of neuron projection development	GO:010976	9.9	NTRK1, FGFR1, RET, LIF, NTRK2
18	embryo implantation	GO:007566	9.8	CALCA, LIF, EPO, BSG
19	regulation of angiogenesis	GO:045765	9.7	FGF2, EGLN1, NF1, IL6
20	MAPK cascade	GO:000165	9.7	RET, EGFR, NF1, NRTN, MEN1, FGFR1
21	response to hypoxia	GO:001666	9.5	EGLN1, TH, HIF1A, EDNRA, NF1, BCL2
22	positive regulation of MAPK cascade	GO:043410	9.3	KIT, NTRK2, IGF2, IL6, FGFR1, LIF
23	angiogenesis	GO:001525	9.3	TYMP, HIF1A, FGFR1, PTEN, MMP2, SCG2
24	negative regulation of cell migration	GO:030336	9.3	ENG, PTEN, NKX2-1, BCL2, NF1
25	negative regulation of neuron apoptotic process	GO:043524	9.2	BCL2, NTRK1, HIF1A, NTRK2, NTF3
26	small molecule metabolic process	GO:044281	9.1	BSG, SDHA, SDHC, IDH2, B3GAT1, SDHD
27	response to estrogen stimulus	GO:043627	9.0	GAL, EPO, CCND1, BCL2, KRT19
28	response to ethanol	GO:045471	8.9	BCL2, TH, ACTC1, NKX2-1, CCND1
29	negative regulation of cell proliferation	GO:008285	8.5	SSTR2, SST, PTEN, TMEM127, CDKN2A, NTRK1
30	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.2	NTF3, CDKN2A, LIF, ASCL1, MEN1, IL6
31	signal transduction	GO:007165	8.1	EGFR, EDNRA, EDN3, STMN1, EPO, EPAS1
32	negative regulation of apoptotic process	GO:043066	7.5	PTEN, EPO, EGFR, EDNRA, IL6, FGFR1
33	positive regulation of cell proliferation	GO:008284	7.0	EPO, EGFR, IL6, EDNRA, NTRK2, PTEN

Molecular functions related to paraganglioma according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	succinate dehydrogenase activity	GO:000104	10.4	SDHA, SDHD, SDHC
2	neuropeptide hormone activity	GO:005184	10.2	ADCYAP1, NPY, GRP, GAL, VIP
3	neurotrophin binding	GO:043121	9.8	NTRK2, NTRK1, NTRK3
4	hormone activity	GO:005179	9.3	POMC, VIP, CHGB, IGF2, CALCA, SST
5	receptor binding	GO:005102	9.3	NTF3, IDH1, REN, LIF, GRP, CALCA
6	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.2	RET, KIT, NTRK1, NTRK3, EGFR
7	protein homodimerization activity	GO:042803	8.6	KIT, BNIP3, BCL2, S100A1, S100B, ASCL1
8	growth factor activity	GO:008083	8.5	LIF, NTF3, FGF2, IL6, IGF2, NRTN
9	identical protein binding	GO:042802	8.2	PCNA, VIM, BNIP3, BCL2, S100A1, S100B
10	protein binding	GO:005515	3.4	PCNA, KIT, RET, MEN1, VIM, BSG