Paraganglioma and Gastric Stromal Sarcoma malady

MalaCards: Paraganglioma and Gastric Stromal Sarcoma, also known as carney-stratakis dyad of paraganglioma and gastric stromal sarcoma, is related to pheochromocytoma and hereditary paraganglioma-pheochromocytoma syndromes. An important gene associated with Paraganglioma and Gastric Stromal Sarcoma is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are Citric acid cycle (TCA cycle) and Citrate cycle (TCA cycle). The compounds mibg and catecholamine have been mentioned in the context of this disorder.

OMIM: 606864

paraganglioma and gastric stromal sarcoma 30 33 carney-stratakis dyad of paraganglioma and gastric stromal sarcoma 30 paraganglioma and gastrointestinal stromal tumor 30 carney-stratakis syndrome 30

paraganglioma and gist 30 paraganglioma 43 carney dyad 30

Diseases related to paraganglioma and gastric stromal sarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 81)

id	Related Disease	Score	Top Affiliating Genes
1	pheochromocytoma	33.1	SDHB, SDHC, SDHD
2	hereditary paraganglioma-pheochromocytoma syndromes	31.9	SDHB, SDHC, SDHD
3	gastrointestinal stromal tumor	31.1	SDHB, SDHC, SDHD
4	carney triad	30.5	SDHD, SDHC, SDHB
5	chondroma	29.1	SDHB, SDHC, SDHD
6	paraganglioma	29.1	SDHB, SDHC, SDHD
7	sarcoma	28.6	SDHB, SDHC, SDHD
8	carotid body tumor	28.0	SDHD, SDHC, SDHB
9	cervicitis	26.8	SDHD, SDHC, SDHB
10	von hippel-lindau disease	26.5	SDHD, SDHC, SDHB
11	thyroid carcinoma	26.3	SDHB, SDHC, SDHD
12	hypoxia	26.3	SDHB, SDHC, SDHD
13	mediastinitis	26.1	SDHD, SDHB
14	mitochondrial complex ii deficiency	25.2	SDHD, SDHC, SDHB
15	adrenocortical tumor	25.2	SDHD, SDHC, SDHB
16	multiple endocrine neoplasia	25.2	SDHB, SDHC, SDHD
17	thyroid cancer	25.0	SDHD, SDHC, SDHB
18	renal cell carcinoma	24.8	SDHB, SDHC, SDHD
19	adenoma	24.8	SDHB, SDHC, SDHD
20	cowden-like syndrome	12.7	SDHB, SDHD
21	neurofibromatosis	12.6	SDHB, SDHD
22	glomus tumor	12.6	SDHB, SDHD
23	cranial nerve palsy	12.4	SDHC, SDHD
24	nasopharynx carcinoma	12.3	SDHD, SDHC
25	insulinoma	12.2	SDHB, SDHD
26	neural crest tumor	11.9	SDHB, SDHC, SDHD
27	familial medullary thyroid carcinoma	11.9	SDHD, SDHC, SDHB
28	familial renal cell carcinoma	11.9	SDHB, SDHC, SDHD
29	multiple endocrine neoplasia type 2a	11.9	SDHD, SDHC, SDHB
30	wermer syndrome	11.9	SDHB, SDHC, SDHD
31	adrenal adenoma	11.9	SDHB, SDHC, SDHD
32	hemangioma	11.9	SDHD, SDHC, SDHB
33	hyperparathyroidism	11.8	SDHD, SDHC, SDHB
34	acute leukemia	11.8	SDHD, SDHC, SDHB
35	huntington's disease	11.8	SDHB, SDHC, SDHD
36	parkinson's disease	11.7	SDHB, SDHC, SDHD
37	gastric cancer	11.5	SDHB, SDHC, SDHD
38	sdhb-related paraganglioma and gastric stromal sarcoma	9.6
39	sdhc-related paraganglioma and gastric stromal sarcoma	9.6
40	sdhd-related paraganglioma and gastric stromal sarcoma	9.6
41	paragangliomas 4	8.4
42	paragangliomas 1	8.1
43	paragangliomas 2	8.1
44	nonsyndromic paraganglioma	8.0
45	paragangliomas 3	8.0
46	thyroiditis	7.6
47	carcinoma	7.4
48	sdhd-related hereditary paraganglioma-pheochromocytoma syndrome	7.0
49	duodenitis	7.0
50	hereditary paraganglioma-pheochromocytoma multi-gene panels	7.0

Clinical features from OMIM: 606864

Approved drugs:

Drug clinical trials:

Genes related to paraganglioma and gastric stromal sarcoma according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	11.0
2	SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	11.0
3	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.0

Pathways related to paraganglioma and gastric stromal sarcoma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Citric acid cycle (TCA cycle)38	8.7	SDHD, SDHC, SDHB
2	Citrate cycle (TCA cycle)20	8.6	SDHC, SDHB, SDHD
3	Parkinsons disease20	8.6	SDHD, SDHC, SDHB
4	Oxidative phosphorylation20	8.5	SDHD, SDHC, SDHB
5	Metabolic pathways20	8.5	SDHD, SDHC, SDHB
6	Alzheimers disease20	8.4	SDHB, SDHD, SDHC
7	Huntingtons disease20	8.2	SDHD, SDHC, SDHB

Compounds related to paraganglioma and gastric stromal sarcoma according to GeneDecks:

(show all 12)

id	Compound	Score	Top Affiliating Genes
1	mibg32	9.4	SDHD, SDHB
2	catecholamine32	9.0	SDHD, SDHB
3	Heme9 18 9	11.0	SDHC, SDHD
4	UBIQUINONE-19 9	9.8	SDHD, SDHC, SDHB
5	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol9 9	9.7	SDHB, SDHC, SDHD
6	fumarate32 9 9	10.7	SDHD, SDHC, SDHB
7	iron-sulfur32	8.7	SDHB, SDHD, SDHC
8	Succinic acid9 18 9	10.7	SDHD, SDHC, SDHB
9	ubiquinone32	8.7	SDHC, SDHB, SDHD
10	succinate32	8.6	SDHB, SDHC, SDHD
11	iron32 18	9.5	SDHD, SDHB, SDHC
12	oxygen32 18	9.4	SDHB, SDHD, SDHC

Cellular components related to paraganglioma and gastric stromal sarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrion	GO:005739	8.5	SDHB, SDHC, SDHD
2	mitochondrial respiratory chain complex II	GO:005749	8.4	SDHB, SDHC, SDHD
3	mitochondrial inner membrane	GO:005743	8.2	SDHB, SDHC, SDHD

Biological processes related to paraganglioma and gastric stromal sarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	aerobic respiration	GO:009060	8.8	SDHC, SDHB
2	tricarboxylic acid cycle	GO:006099	8.5	SDHB, SDHC, SDHD
3	small molecule metabolic process	GO:044281	8.5	SDHB, SDHC, SDHD
4	respiratory electron transport chain	GO:022904	8.4	SDHD, SDHC, SDHB

Molecular functions related to paraganglioma and gastric stromal sarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ubiquinone binding	GO:048039	9.2	SDHB, SDHD
2	succinate dehydrogenase activity	GO:000104	9.0	SDHC, SDHD
3	heme binding	GO:020037	9.0	SDHC, SDHD
4	electron carrier activity	GO:009055	8.2	SDHB, SDHC, SDHD