Paraganglioma, Familial Chromaffin, 4 malady

MalaCards: Paraganglioma, Familial Chromaffin, 4, also known as paraganglioma, is related to paraganglioma and hereditary paraganglioma-pheochromocytoma syndromes. An important gene associated with Paraganglioma, Familial Chromaffin, 4 is SDHB (succinate dehydrogenase complex, subunit B, iron sulfur (Ip)).

OMIM: 115310

paraganglioma, familial chromaffin, 4 33 paraganglioma 43

Diseases related to paraganglioma, familial chromaffin, 4 by text searches and GeneDecks gene sharing:

(show all 40)

id	Related Disease	Score	Top Affiliating Genes
1	paraganglioma	12.1
2	hereditary paraganglioma-pheochromocytoma syndromes	9.3
3	paragangliomas 4	8.4
4	paragangliomas 1	8.1
5	paragangliomas 2	8.1
6	paragangliomas 3	8.0
7	nonsyndromic paraganglioma	8.0
8	paraganglioma and gastric stromal sarcoma	7.4
9	hereditary paraganglioma-pheochromocytoma multi-gene panels	7.0
10	sdhc-related hereditary paraganglioma-pheochromocytoma syndrome	7.0
11	sdhd-related hereditary paraganglioma-pheochromocytoma syndrome	7.0
12	carney triad	6.7
13	carotid body tumor	6.7
14	sdha-related hereditary paraganglioma-pheochromocytoma syndrome	6.7
15	sdhb-related paraganglioma and gastric stromal sarcoma	6.7
16	sdhc-related paraganglioma and gastric stromal sarcoma	6.7
17	sdhd-related paraganglioma and gastric stromal sarcoma	6.7
18	paragangliomas, familial nonchromaffin, 3	6.3
19	paragangliomas, familial nonchromaffin, 1, with or without deafness	6.3
20	sdhaf2-related hereditary paraganglioma-pheochromocytoma syndrome	6.3
21	erythrocytosis	6.3
22	chondroma	5.8
23	gastrointestinal stromal tumor	5.8
24	max-related hereditary paraganglioma-pheochromocytoma syndrome	5.8
25	von hippel-lindau disease	5.8
26	carcinoid tumors	4.9
27	carotid body cancer	4.9
28	duodenal somatostatinoma	4.9
29	nevus	4.9
30	glomus jugulare tumors	4.9
31	glomus tympanicum tumor	4.9
32	glomus vagale tumors	4.9
33	somatostatinoma	4.9
34	ganglioneuroma	4.9
35	mediastinitis	4.9
36	abdominal chemodectomas with cutaneous angiolipomas	4.9
37	merkel cell carcinoma	4.9
38	mitochondrial complex ii deficiency	4.9
39	clear cell sarcoma	4.9
40	neuroendocrine carcinoma	4.9

Clinical features from OMIM: 115310

Approved drugs:

Drug clinical trials:

Genes related to paraganglioma, familial chromaffin, 4 according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.1	Disorders