PIV3
MCID: PRN029
MIFTS: 33

Parainfluenza Virus Type 3 (PIV3) malady

Summaries for Parainfluenza Virus Type 3

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MalaCards: Parainfluenza Virus Type 3, also known as human parainfluenza virus type 3, is related to pneumonia and vaccinia. An important gene associated with Parainfluenza Virus Type 3 is NEU1 (sialidase 1 (lysosomal sialidase)), and among its related pathways are Glucocorticoid receptor regulatory network and Immune response IFN gamma signaling pathway. The compounds indoleamine and estrogen have been mentioned in the context of this disorder. Related mouse phenotypes are liver/biliary system and cellular.

Aliases & Classifications for Parainfluenza Virus Type 3

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42NIH Rare Diseases
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Aliases & Descriptions:

parainfluenza virus type 3 42
human parainfluenza virus type 3 42
piv3 42


Related Diseases for Parainfluenza Virus Type 3

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17GeneCards, 18GeneDecks
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Diseases related to Parainfluenza Virus Type 3 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.1ICAM1, NEU1
2vaccinia30.7FURIN, IL2
3influenza30.7NEU1, RNPC3, DDX58, STAT1, CRAT, IFNB1
4measles30.5MX1, RNPC3, STAT1, IFNB1
5newcastle disease30.3NEU1, IFNB1, IFNA1
6herpes simplex30.3EIF2AK2, MX1, RNASEL, NEU1, IFNA1, IFNB1
7meningitis10.5
8viral pneumonia10.4
9diarrhea10.4
10hydrocephalus10.4
11pertussis10.4
12fetal parainfluenza virus type 3 syndrome10.4
13bronchiolitis10.2
14urethritis10.2
15swine influenza10.2
16stevens-johnson syndrome10.2
17aseptic meningitis10.2
18meningoencephalitis10.2
19parotitis10.2
20bronchopneumonia10.2
21venezuelan equine encephalitis10.0FURIN
22nephritis10.0RNPC3
23biliary atresia10.0MX1
24lupus erythematosus10.0MX1
25rubella10.0RNPC3
26pancreatitis10.0ICAM1
27lupus nephritis10.0ICAM1
28chronic mucocutaneous candidiasis10.0STAT1
29vasculitis10.0ICAM1
30graves' disease10.0ICAM1
31dermatitis10.0ICAM1
32ebola hemorrhagic fever10.0DDX58
33hyperglycemia10.0IFNB1
34alopecia areata10.0ICAM1
35myopathy10.0CRAT
36myositis10.0ICAM1, RNPC3
37dementia10.0STAT1
38rabies10.0RNPC3, MX1
39myocarditis10.0IFNB1
40sjogren's syndrome10.0ICAM1, RNPC3
41pancreatic cancer10.0GAPDH
42polymyositis10.0ICAM1, RNPC3
43allergic rhinitis10.0ICAM1
44lichen planus10.0ICAM1, MX1
45dermatomyositis10.0MX1, ICAM1
46thyroiditis10.0IFNA1
47uveitis10.0ICAM1, RNPC3
48cystic fibrosis10.0FURIN
49papilloma10.0GAPDH
50rhinitis10.0ICAM1

Graphical network of the top 20 diseases related to Parainfluenza Virus Type 3:



Diseases related to parainfluenza virus type 3

Clinical Features for Parainfluenza Virus Type 3

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Drugs & Therapeutics for Parainfluenza Virus Type 3

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Parainfluenza Virus Type 3

Drug clinical trials:

Search ClinicalTrials for Parainfluenza Virus Type 3

Search NIH Clinical Center for Parainfluenza Virus Type 3

Search CenterWatch for Parainfluenza Virus Type 3

Genetic Tests for Parainfluenza Virus Type 3

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Anatomical Context for Parainfluenza Virus Type 3

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Animal Models for Parainfluenza Virus Type 3 or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Parainfluenza Virus Type 3:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6FURIN, IL2, NEU1, DDX58, STAT1, GAPDH
2MP:00053848.5IFIH1, EIF2AK2, IFNB1, STAT1, DDX58, NEU1
3MP:00020068.4IFNB1, EIF2AK2, IL2, DDX58, STAT1, ICAM1
4MP:00053877.4IFIH1, IFNB1, ICAM1, STAT1, NEU1, PRKCZ
5MP:00053977.1PRKCZ, EIF2AK2, IL2, GAPDH, DDX58, STAT1
6MP:00053766.5IFIH1, IFNB1, ICAM1, IL2, PRKCZ, NEU1

Publications for Parainfluenza Virus Type 3

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Genetic Variations for Parainfluenza Virus Type 3

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Expression for genes affiliated with Parainfluenza Virus Type 3

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Parainfluenza Virus Type 3

Search GEO for disease gene expression data for Parainfluenza Virus Type 3.

Pathways for genes affiliated with Parainfluenza Virus Type 3

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37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 53Reactome, 51QIAGEN
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Pathways related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6STAT1, ICAM1, IL2
2
Immune response IFN gamma signaling pathway
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9.6EIF2AK2, STAT1, ICAM1
3
Translation Insulin regulation of translation
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9.2EIF2AK2, NCL, PRKCZ
49.1STAT1, IFNB1, ICAM1, EIF2AK2
5
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9.0IFNA1, IFNB1, IFIH1
68.9IFNA1, DDX58, IFNB1
78.9IFNB1, STAT1, IFNA1
88.9IL2, IFNB1, IFNA1
9
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8.7IFIH1, IFNA1, DDX58, IFNB1
108.6IL2, STAT1, IFNB1, IFNA1
11
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8.6IL2, ICAM1, IFNB1, IFNA1
12
Immune response IFN alpha/beta signaling pathway
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8.5MX1, RNASEL, STAT1, IFNB1, IFNA1
138.4IL2, PRKCZ, IFNA1, IFNB1
14
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8.1DDX58, STAT1, IFNB1, IFNA1, IFIH1, IL2
15
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8.1IL2, IFNA1, IFNB1, STAT1, PRKCZ
168.1IFNA1, IFNB1, DDX58, RNASEL, EIF2AK2, STAT1
17
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7.3EIF2AK2, IFNA1, IFNB1, ICAM1, DDX58, RNASEL
18
Hide members
6.8STAT1, MX1, EIF2AK2, IL2, RNASEL, DDX58
19
Hide members
6.5MX1, EIF2AK2, DDX58, RNASEL, IL2, IFIH1

Compounds for genes affiliated with Parainfluenza Virus Type 3

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44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1indoleamine4410.4STAT1
2estrogen4410.3FURIN
3pge24410.0CRAT, IL2
4poly c449.7IFNB1, RNPC3, EIF2AK2
5ampligen449.5IFNA1, RNASEL
6levamisole44 1110.4IL2, IFNA1, NEU1
7rebif449.4MX1, IFNB1, IFNA1
8avonex449.4MX1, IFNB1, IFNA1
9betaseron449.4MX1, IFNA1, IFNB1
10ribavirin44 49 1111.3MX1, STAT1, EIF2AK2, IL2, RNASEL, NEU1
11rrna449.3RNPC3, RNASEL, NCL, GAPDH
12glatiramer acetate44 1110.3IL2, IFNB1, IFNA1
13tetracycline44 1110.2FURIN, IFNB1, EIF2AK2, CRAT
14neomycin449.2IL2, RNPC3, CRAT, IFNB1
15acyclovir44 1110.2IFNA1, IFNB1, NEU1
16dacarbazine44 1110.1IFNB1, IL2, IFNA1
17cycloheximide449.1IFNA1, IFNB1, STAT1, MX1
18imiquimod44 28 59 1112.1IFNA1, MX1, STAT1, IFNB1
19temozolomide44 1110.1IFNA1, IFNB1, IL2
20biotin44 11 2411.1IL2, RNPC3, STAT1, GAPDH
21aspartate449.0CRAT, EIF2AK2, GAPDH, FURIN
22zidovudine44 1110.0IFNB1, NEU1, IFNA1, IL2
23inosine monophosphate449.0EIF2AK2, STAT1, IFNA1, IFNB1
24chloroquine44 2 49 28 1112.8EIF2AK2, IFNA1, IFNB1, IL2
25polyethylene glycol448.8IFNA1, GAPDH, NEU1, ICAM1
26neopterin448.8ICAM1, IL2, IFNB1, IFNA1, MX1
27tamoxifen44 49 28 1111.6CRAT, IL2, IFNA1, IFNB1
28poly(i-c)448.5IFNA1, STAT1, IFNB1, DDX58, EIF2AK2, MX1
29arginine448.5RNPC3, EIF2AK2, STAT1, FURIN, CRAT, RNASEL
30heparin44 28 11 2411.5IFNB1, GAPDH, NEU1, EIF2AK2, NCL, FURIN
31rantes448.4STAT1, EIF2AK2, IL2, IFNB1, IFNA1, ICAM1
32adenine44 11 2410.4IFNB1, RNPC3, RNASEL, GAPDH, EIF2AK2, CRAT
33serine448.3MX1, EIF2AK2, NCL, PRKCZ, STAT1, NEU1
34ly294002448.3STAT1, GAPDH, ICAM1, IFNB1, PRKCZ
35ifn-alpha448.2RNASEL, IL2, EIF2AK2, MX1, IFNB1, STAT1
36vegf448.2IFNB1, IFNA1, GAPDH, STAT1, PRKCZ
37retinoid448.1IFNA1, IFNB1, GAPDH, STAT1, CRAT
38adenylate448.1NCL, IFNB1, GAPDH, CRAT, RNPC3, RNASEL
39h2o2448.0NEU1, STAT1, CRAT, GAPDH, ICAM1, IFNB1
40nitric oxide44 11 2410.0ICAM1, PRKCZ, GAPDH, CRAT, EIF2AK2, RNASEL
41atp44 288.9MX1, NCL, RNPC3, RNASEL, EIF2AK2, STAT1
42cisplatin44 49 59 1110.8GAPDH, IFNA1, IL2, STAT1, CRAT, IFNB1
43cyclosporin a44 28 599.7IL2, RNPC3, IFNA1, ICAM1, GAPDH, STAT1
442,5-oligoadenylate447.7IFNA1, MX1, EIF2AK2, IL2, RNASEL, STAT1
45polyinosinic-polycytidylic acid447.7IFNA1, EIF2AK2, IFNB1, STAT1, DDX58, IL2
46oligonucleotide447.7RNASEL, EIF2AK2, IFNB1, GAPDH, CRAT, RNPC3
47rapamycin447.6STAT1, IL2, PRKCZ, IFNA1, GAPDH
48tyrosine447.3STAT1, RNPC3, IL2, EIF2AK2, IFNB1, IFNA1
49actinomycin d447.2CRAT, GAPDH, STAT1, IL2, IFNA1, IFNB1
50retinoic acid44 246.9EIF2AK2, IFIH1, NCL, PRKCZ, NEU1, DDX58

GO Terms for genes affiliated with Parainfluenza Virus Type 3

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16Gene Ontology
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Cellular components related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058297.7MX1, EIF2AK2, RNASEL, PRKCZ, DDX58, STAT1

Biological processes related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cytoplasmic pattern recognition receptor signaling pathway in response to virusGO:03952810.2IFIH1, DDX58
2regulation of type III interferon productionGO:03434410.2IFIH1, DDX58
3detection of virusGO:00959710.1DDX58, IFIH1
4positive regulation of interferon-alpha productionGO:03272710.1DDX58, IFIH1
5response to exogenous dsRNAGO:0433309.9STAT1, DDX58
6type I interferon-mediated signaling pathwayGO:0603379.5MX1, RNASEL, STAT1, IFNB1
7negative regulation of viral genome replicationGO:0450719.5MX1, EIF2AK2, RNASEL, IFNB1
8natural killer cell activationGO:0301019.4IFNB1, IL2
9positive regulation of NF-kappaB transcription factor activityGO:0510929.3EIF2AK2, PRKCZ, ICAM1
10cytokine-mediated signaling pathwayGO:0192219.2IFNB1, ICAM1, STAT1, RNASEL, MX1
11modulation by virus of host morphology or physiologyGO:0190489.2IFIH1, ICAM1, STAT1, DDX58, EIF2AK2
12response to virusGO:0096159.2IFIH1, IFNB1, DDX58, EIF2AK2, MX1
13defense response to virusGO:0516079.2IFNB1, STAT1, RNASEL, EIF2AK2, MX1
14innate immune responseGO:0450879.0IFIH1, IFNB1, DDX58, EIF2AK2, MX1
15positive regulation of transcription from RNA polymerase II promoterGO:0459449.0IL2, RNASEL, DDX58, STAT1, IFNB1

Molecular functions related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-stranded RNA bindingGO:0037259.6EIF2AK2, DDX58, IFIH1

Products for genes affiliated with Parainfluenza Virus Type 3

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  • Antibodies
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Sources for Parainfluenza Virus Type 3

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet