PIV3
MCID: PRN029
MIFTS: 49

Parainfluenza Virus Type 3 (PIV3) malady

Rare diseases category
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Summaries for Parainfluenza Virus Type 3

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MalaCards based summary: Parainfluenza Virus Type 3, also known as human parainfluenza virus type 3, is related to measles and newcastle disease. An important gene associated with Parainfluenza Virus Type 3 is NEU1 (sialidase 1 (lysosomal sialidase)), and among its related pathways are Cytokines and Inflammatory Response and Immune response MIF mediated glucocorticoid regulation. The compounds rebif and avonex have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and bone marrow, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Parainfluenza Virus Type 3

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Parainfluenza Virus Type 3, Aliases & Descriptions:

Name: Parainfluenza Virus Type 3 42
Human Parainfluenza Virus Type 3 42
 
Piv3 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Parainfluenza Virus Type 3

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Diseases related to Parainfluenza Virus Type 3 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1measles31.0MX1, STAT1, RNPC3, IFNB1
2newcastle disease30.8IFNB1, IFNA1, NEU1
3herpes simplex29.8IFNA1, STAT1, NEU1, MX1, EIF2AK2, CRAT
4influenza29.6MX1, EIF2AK2, NEU1, RNPC3, FURIN, DDX58
5pneumonia10.8
6vaccinia10.6
7venezuelan equine encephalitis10.6FURIN
8meningitis10.5
9chronic inflammatory demyelinating polyneuropathy10.5IFNB1
10rift valley fever10.5MX1
11hydrocephalus10.4
12diarrhea10.4
13pertussis10.4
14fetal parainfluenza virus type 3 syndrome10.4
15hemophagocytic lymphohistiocytosis10.4MX1, IFNB1
16rabies10.4RNPC3, MX1
17dengue disease10.4RNASEL, NEU1, IFNB1
18myocarditis10.3IFNB1
19chronic fatigue syndrome10.3EIF2AK2, RNASEL
20stevens-johnson syndrome10.3
21bronchiolitis10.3
22urethritis10.3
23swine influenza10.3
24aseptic meningitis10.3
25bronchopneumonia10.3
26meningoencephalitis10.3
27parotitis10.3
28toxic epidermal necrolysis10.3
29blindness10.3
30subacute sclerosing panencephalitis10.3MX1, IFNA1
31mumps10.3STAT1, NEU1, EIF2AK2
32dermatomyositis10.2MX1, ICAM1
33thyroiditis10.2IFNA1
34hypothyroidism10.2IFNA1, IFNB1
35immunoglobulin a vasculitis10.2MX1, ICAM1
36acute erythroid leukemia10.2CRAT, IFNB1, STAT1
3721-hydroxylase deficiency10.2IFNB1, IFNA1
38cervical cancer10.2CRAT, STAT1, IFNB1
39hepatitis10.2IFNA1, IFNB1, STAT1
40tropical spastic paraparesis10.1IL2, IFNB1
41allergic asthma10.1ICAM1, STAT1, IFNB1
42down syndrome10.1GAPDH, MX1, NCL
43viral hepatitis10.1MX1, IFNA1, STAT1, IFNB1
44malaria10.1ICAM1, NEU1, GAPDH
45berger disease10.0NEU1, ICAM1, GAPDH
46malignant glioma10.0NEU1, CRAT, FURIN, STAT1, IFNB1
47choriocarcinoma10.0CRAT, GAPDH, STAT1
48hepatitis d10.0IFNA1, NCL, EIF2AK2, RNPC3
49sezary's disease10.0IFNA1, IL2
50hairy cell leukemia10.0IL2, IFNB1, IFNA1

Graphical network of the top 20 diseases related to Parainfluenza Virus Type 3:



Diseases related to parainfluenza virus type 3

Symptoms for Parainfluenza Virus Type 3

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Drugs & Therapeutics for Parainfluenza Virus Type 3

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Drug clinical trials:

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Search NIH Clinical Center for Parainfluenza Virus Type 3

Genetic Tests for Parainfluenza Virus Type 3

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Anatomical Context for Parainfluenza Virus Type 3

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MalaCards organs/tissues related to Parainfluenza Virus Type 3:

32
Lung, T cells, Bone marrow, Bone, Liver, Testes, Monocytes

Animal Models for Parainfluenza Virus Type 3 or affiliated genes

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MGI Mouse Phenotypes related to Parainfluenza Virus Type 3:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7DDX58, ICAM1, STAT1, IL2, EIF2AK2, IFNB1
2MP:00053708.4FURIN, NEU1, STAT1, IL2, GAPDH, DDX58
3MP:00053847.9CRAT, EIF2AK2, IL2, IFIH1, STAT1, ICAM1
4MP:00053857.8IL2, GAPDH, FURIN, NEU1, ICAM1, STAT1
5MP:00053787.7ICAM1, DDX58, FURIN, NEU1, STAT1, GAPDH
6MP:00053877.2IL2, EIF2AK2, RNASEL, PRKCZ, ICAM1, FURIN
7MP:00107687.0IFIH1, IL2, GAPDH, EIF2AK2, STAT1, ICAM1
8MP:00053767.0GAPDH, CRAT, IFIH1, IFNB1, ICAM1, NEU1
9MP:00053976.7STAT1, ICAM1, PRKCZ, NEU1, IFNB1, EIF2AK2

Publications for Parainfluenza Virus Type 3

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Articles related to Parainfluenza Virus Type 3:

(show top 50)    (show all 257)
idTitleAuthorsYear
1
Phosphoprotein of human parainfluenza virus type 3 blocks autophagosome-lysosome fusion to increase virus production. (24832451)
2014
2
Chimeric bovine/human parainfluenza virus type 3 expressing respiratory syncytial virus (RSV) F glycoprotein: effect of insert position on expression, replication, immunogenicity, stability, and protection against RSV infection. (24478424)
2014
3
Prevalence of antibodies against Parainfluenza virus type 3, Respiratory syncitial virus and bovine Herpesvirus type 1 in sheep from Northern Prefectures of Japan. (24166480)
2013
4
Comparison of differing cytopathic effects in human airway epithelium of parainfluenza virus 5 (W3A), parainfluenza virus type 3, and respiratory syncytial virus. (21986028)
2011
5
Identification of simian agent 10 as human parainfluenza virus type 3 suggests transmission of a human virus to an African monkey. (20881043)
2010
6
Phosphoprotein, P of human parainfluenza virus type 3 prevents self-association of RNA-dependent RNA polymerase, L. (19012944)
2009
7
Evidence for phosphorylation of human parainfluenza virus type 3 C protein: mutant C proteins exhibit variable inhibitory activities in vitro. (19410612)
2009
8
Natural killer cells regulate T-cell proliferation during human parainfluenza virus type 3 infection. (18614637)
2008
9
Molecular investigations of an outbreak of parainfluenza virus type 3 and respiratory syncytial virus infections in a hematology unit. (17392447)
2007
10
A chimeric alphavirus RNA replicon gene-based vaccine for human parainfluenza virus type 3 induces protective immunity against intranasal virus challenge. (17052811)
2007
11
Roles of human parainfluenza virus type 3 bases 13 to 78 in replication and transcription: identification of an additional replication promoter element and evidence for internal transcription initiation. (16699019)
2006
12
Interferon action against human parainfluenza virus type 3: involvement of a novel antiviral pathway in the inhibition of transcription. (11312354)
2001
13
Human parainfluenza virus type 3 HN-receptor interaction: effect of 4-guanidino-Neu5Ac2en on a neuraminidase-deficient variant. (11462020)
2001
14
A single amino acid substitution in the viral polymerase creates a temperature-sensitive and attenuated recombinant bovine parainfluenza virus type 3. (11601905)
2001
15
Antibody responses to bovine parainfluenza virus type 3 (PIV3) vaccination and human PIV3 infection in young infants. (11509996)
2001
16
Role of NH(2)- and COOH-terminal domains of the P protein of human parainfluenza virus type 3 in transcription and replication. (10846069)
2000
17
Sequence determination and molecular analysis of two strains of bovine parainfluenza virus type 3 that are attenuated for primates. (10872880)
2000
18
Specific phosphorylated forms of glyceraldehyde 3-phosphate dehydrogenase associate with human parainfluenza virus type 3 and inhibit viral transcription in vitro. (10729139)
2000
19
Precise mapping of the replication and transcription promoters of human parainfluenza virus type 3. (10725212)
2000
20
Long nucleotide insertions between the HN and L protein coding regions of human parainfluenza virus type 3 yield viruses with temperature-sensitive and attenuation phenotypes. (10873765)
2000
21
Mutations in the C, D, and V open reading frames of human parainfluenza virus type 3 attenuate replication in rodents and primates. (10497117)
1999
22
Immune responses and protection induced by DNA vaccines encoding bovine parainfluenza virus type 3 glycoproteins. (10405354)
1999
23
Three amino acid substitutions in the L protein of the human parainfluenza virus type 3 cp45 live attenuated vaccine candidate contribute to its temperature-sensitive and attenuation phenotypes. (9499025)
1998
24
Interaction of human parainfluenza virus type 3 with the host cell surface. (9380464)
1997
25
Rescue of Sendai virus cDNA templates with cDNA clones expressing parainfluenza virus type 3 N, P and L proteins. (8887479)
1996
26
Some virological and pathomorphological aspects of the respiratory system in the experimental infection with respiratory syncytial virus associated with influenza virus, parainfluenza virus type 3 and adenovirus in the mouse. (9495783)
1996
27
Human parainfluenza virus type 3: analysis of the cytoplasmic tail and transmembrane anchor of the hemagglutinin-neuraminidase protein in promoting cell fusion. (7653094)
1995
28
Sequence variation in the haemagglutinin-neuraminidase gene of human parainfluenza virus type 3 isolates in the UK. (7781737)
1995
29
Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2. (8139055)
1994
30
A prototype recombinant vaccine against respiratory syncytial virus and parainfluenza virus type 3. (7765021)
1994
31
Parainfluenza virus type 3 and pertussis syndrome. (8244477)
1993
32
Parainfluenza virus type 3 (PIV3)-specific and non-virus-specific delayed type hypersensitivity responses in cotton rats given different PIV3 antigen preparations. (8383384)
1993
33
Isolation of parainfluenza virus type 3 from cerebrospinal fluid. (1316416)
1992
34
RNA editing in the phosphoprotein gene of the human parainfluenza virus type 3. (1310183)
1992
35
Fusion properties of cells persistently infected with human parainfluenza virus type 3: participation of hemagglutinin-neuraminidase in membrane fusion. (1851852)
1991
36
Defective interfering particles of human parainfluenza virus type 3 are associated with persistent infection in cell culture. (1649512)
1991
37
Parainfluenza virus type 3: surveillance. (1669815)
1991
38
Human parainfluenza virus type 3 transcription in vitro: role of cellular actin in mRNA synthesis. (1851877)
1991
39
Outbreak of parainfluenza virus type 3 in a neonatal nursery. (2153949)
1990
40
Antibodies to parainfluenza virus type 3 in Minnesota swine. (2849496)
1988
41
Protection of weanling hamsters from experimental infection with wild-type parainfluenza virus type 3 (para 3) by cold-adapted mutants of para 3. (3005486)
1986
42
Parainfluenza virus type 3 in pigs. (3024379)
1986
43
The effect of parainfluenza virus type 3 on the phagocytic cell response of the ovine lung to Pasteurella haemolytica. (3010545)
1986
44
Conserved structures among the nucleocapsid proteins of the paramyxoviridae: complete nucleotide sequence of human parainfluenza virus type 3 NP mRNA. (3012866)
1986
45
Properties of temperature-sensitive mutants of parainfluenza virus type 3 selected during the course of persistent infection. (2986583)
1985
46
Evidence of a T-cell-mediated cytotoxic response to parainfluenza virus type 3 pneumonia in hamsters. (6278144)
1982
47
The effect of vaccination of lambs with live parainfluenza virus type 3 on pneumonia produced by parainfluenza virus type 3 and Pasteurella haemolytica. (6258113)
1980
48
Pulmonary cell-mediated cytotoxicity in hamsters with parainfluenza virus type 3 pneumonia. (223482)
1979
49
Respiratory infection of lambs with an ovine strain parainfluenza virus type 3. (4309242)
1969
50
Cytopathic effects of parainfluenza virus Type 3 in organ cultures of human respiratory tract tissue. (4295104)
1968

Variations for Parainfluenza Virus Type 3

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Expression for genes affiliated with Parainfluenza Virus Type 3

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Expression patterns in normal tissues for genes affiliated with Parainfluenza Virus Type 3

Search GEO for disease gene expression data for Parainfluenza Virus Type 3.

Pathways for genes affiliated with Parainfluenza Virus Type 3

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Pathways related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL2, IFNB1
29.9ICAM1, IL2
39.6STAT1, IL2, ICAM1
49.5IFNA1, IFNB1, STAT1
59.5IFNA1, STAT1, IFNB1
69.4IFNB1, IFNA1, IL2
7
Show member pathways
IFN-gamma pathway37
9.4ICAM1, EIF2AK2, STAT1
8
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4STAT1, IL2, EIF2AK2
9
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.2PRKCZ, IL2, STAT1
10
Show member pathways
9.2DDX58, IFNB1, IFNA1, IFIH1
11
Show member pathways
9.2IFIH1, IFNB1, IFNA1, DDX58
129.2EIF2AK2, IFNB1, STAT1, ICAM1
13
Show member pathways
Type III interferon signaling37
9.1IFNA1, IFNB1, IL2, STAT1
14
Show member pathways
Immune response CD16 signaling in NK cells60
9.1ICAM1, IFNA1, IL2, IFNB1
15
Show member pathways
9.0IFNB1, RNASEL, MX1, STAT1, IFNA1
168.8IL2, IFNB1, IFNA1, PRKCZ
17
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.6IFIH1, IFNA1, STAT1, DDX58, IL2, IFNB1
18
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.6EIF2AK2, STAT1, NCL, PRKCZ
19
Show member pathways
8.5IL2, IFNB1, IFNA1, STAT1, PRKCZ
208.5IFNA1, EIF2AK2, IFNB1, DDX58, STAT1, RNASEL
21
Show member pathways
7.6STAT1, RNASEL, DDX58, MX1, IFNA1, IFNB1
22
Show member pathways
7.1IFIH1, IL2, MX1, IFNB1, IFNA1, STAT1

Compounds for genes affiliated with Parainfluenza Virus Type 3

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Compounds related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1rebif449.9IFNB1, IFNA1, MX1
2avonex449.9MX1, IFNA1, IFNB1
3betaseron449.9MX1, IFNB1, IFNA1
4glatiramer acetate44 1110.7IFNB1, IFNA1, IL2
5poly c449.7EIF2AK2, RNPC3, IFNB1
6acyclovir44 1110.7IFNB1, NEU1, IFNA1
7levamisole44 1110.7NEU1, IL2, IFNA1
8dacarbazine44 1110.6IFNA1, IL2, IFNB1
9imiquimod44 61 28 1112.6MX1, IFNB1, IFNA1, STAT1
10neomycin449.5CRAT, RNPC3, IFNB1, IL2
11zidovudine44 50 1111.5IL2, IFNB1, NEU1, IFNA1
12indoleamine449.5STAT1, IFNA1, IFNB1
13tetracycline44 1110.4IFNB1, FURIN, EIF2AK2, CRAT
14inosine monophosphate449.3IFNB1, EIF2AK2, IFNA1, STAT1
15temozolomide44 1110.3IFNA1, IFNB1, IL2
16neopterin449.3IFNA1, IL2, MX1, IFNB1, ICAM1
17chloroquine44 2 50 28 1113.2IFNB1, IL2, EIF2AK2, IFNA1
18rrna449.0RNPC3, RNASEL, NCL, GAPDH
19polyethylene glycol448.9GAPDH, NEU1, ICAM1, IFNA1
20poly(i-c)448.9IFNA1, STAT1, DDX58, EIF2AK2, IFNB1, MX1
21biotin44 24 1110.8STAT1, IL2, GAPDH, RNPC3
22ifn-alpha448.6RNASEL, STAT1, IFNA1, IFNB1, MX1, EIF2AK2
23retinoid448.6IFNA1, IFNB1, GAPDH, CRAT, STAT1
24pge2448.5GAPDH, ICAM1, IFNB1, STAT1, IL2, CRAT
25h2o2448.4STAT1, GAPDH, IFNB1, ICAM1, NEU1, CRAT
26tamoxifen44 50 28 1111.4IFNA1, IL2, GAPDH, CRAT, IFNB1
27dexamethasone44 50 28 1111.4STAT1, IFNA1, IFNB1, IL2, CRAT, ICAM1
28ribavirin44 50 1110.4IFNA1, IFNB1, MX1, STAT1, NEU1, RNASEL
29arginine448.4CRAT, EIF2AK2, NCL, STAT1, RNPC3, RNASEL
30adenine44 24 1110.3GAPDH, RNPC3, RNASEL, EIF2AK2, IFNB1, CRAT
31heparin44 28 24 1111.3GAPDH, NEU1, FURIN, IFNB1, NCL, EIF2AK2
32cisplatin44 50 61 1111.3IFNA1, STAT1, GAPDH, IFNB1, CRAT, IL2
33rantes448.2MX1, EIF2AK2, IFNB1, IFNA1, STAT1, ICAM1
342,5-oligoadenylate448.2CRAT, IL2, IFNB1, IFNA1, STAT1, RNASEL
35polyinosinic-polycytidylic acid448.2EIF2AK2, IL2, IFIH1, IFNB1, STAT1, CRAT
36adenylate448.1IFNB1, RNPC3, RNASEL, FURIN, GAPDH, NCL
37estrogen448.1GAPDH, NCL, CRAT, NEU1, STAT1, IFNB1
38aspartate448.1FURIN, IFNA1, EIF2AK2, IFNB1, CRAT, GAPDH
39rapamycin448.0PRKCZ, STAT1, IFNA1, IL2, GAPDH
40ly294002447.9PRKCZ, ICAM1, STAT1, IFNB1, GAPDH
41nitric oxide44 24 119.7STAT1, ICAM1, GAPDH, EIF2AK2, RNASEL, PRKCZ
42cyclosporin a44 28 619.6GAPDH, IL2, IFNA1, STAT1, ICAM1, RNPC3
43tyrosine447.6EIF2AK2, NCL, IL2, IFNB1, IFNA1, STAT1
44oligonucleotide447.6STAT1, RNASEL, RNPC3, IFNB1, CRAT, NCL
45actinomycin d447.6ICAM1, STAT1, IL2, IFNA1, IFNB1, GAPDH
46atp44 288.5MX1, RNASEL, RNPC3, STAT1, CRAT, NCL
47vegf447.4CRAT, IL2, GAPDH, IFNB1, IFNA1, STAT1
48cycloheximide446.6CRAT, IL2, IFNB1, IFNA1, STAT1, ICAM1
49retinoic acid44 247.1IFIH1, IFNA1, DDX58, NEU1, PRKCZ, NCL
50serine445.6FURIN, NEU1, PRKCZ, STAT1, IFNA1, IL2

GO Terms for genes affiliated with Parainfluenza Virus Type 3

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Cellular components related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:0484718.2PRKCZ, EIF2AK2, GAPDH, MX1
2extracellular vesicular exosomeGO:0700627.5NEU1, PRKCZ, ICAM1, NCL, GAPDH, FURIN
3cytosolGO:0058297.2GAPDH, DDX58, RNASEL, PRKCZ, STAT1, IFIH1

Biological processes related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1regulation of type III interferon productionGO:03434410.2IFIH1, DDX58
2cytoplasmic pattern recognition receptor signaling pathway in response to virusGO:03952810.2IFIH1, DDX58
3detection of virusGO:00959710.2IFIH1, DDX58
4positive regulation of interferon-alpha productionGO:03272710.1DDX58, IFIH1
5response to exogenous dsRNAGO:04333010.0DDX58, STAT1, IFNB1
6natural killer cell activationGO:0301019.9IL2, IFNB1
7positive regulation of interferon-beta productionGO:0327289.9DDX58, IFIH1
8type I interferon signaling pathwayGO:0603379.8RNASEL, STAT1, IFNB1, MX1
9regulation of type I interferon-mediated signaling pathwayGO:0603389.7IFNB1, STAT1
10negative regulation of viral genome replicationGO:0450719.6RNASEL, IFNB1, EIF2AK2, MX1
11viral processGO:0160329.5IFIH1, STAT1, FURIN, DDX58
12cytokine-mediated signaling pathwayGO:0192219.5RNASEL, ICAM1, STAT1, IFNB1, MX1
13positive regulation of transcription from RNA polymerase II promoterGO:0459449.4IL2, IFNB1, STAT1, RNASEL, DDX58
14response to virusGO:0096159.3MX1, EIF2AK2, IFIH1, IFNB1, DDX58
15defense response to virusGO:0516079.3MX1, EIF2AK2, IFNB1, STAT1, RNASEL
16innate immune responseGO:0450879.2DDX58, IFNB1, IFIH1, EIF2AK2, MX1
17positive regulation of NF-kappaB transcription factor activityGO:0510929.1EIF2AK2, ICAM1, PRKCZ

Molecular functions related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single-stranded RNA bindingGO:00372710.0IFIH1, DDX58
2double-stranded RNA bindingGO:0037259.5EIF2AK2, IFIH1, DDX58
3protein kinase activityGO:0046728.8EIF2AK2, PRKCZ, RNASEL
4identical protein bindingGO:0428028.6STAT1, NCL, GAPDH, DDX58
5protein bindingGO:0055156.5IFIH1, STAT1, ICAM1, PRKCZ, RNASEL, DDX58

Products for genes affiliated with Parainfluenza Virus Type 3

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  • Antibodies
  • Proteins
  • Lysates

Sources for Parainfluenza Virus Type 3

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet