MCID: PRN029
MIFTS: 36

Parainfluenza Virus Type 3

Categories: Rare diseases

Aliases & Classifications for Parainfluenza Virus Type 3

MalaCards integrated aliases for Parainfluenza Virus Type 3:

Name: Parainfluenza Virus Type 3 49
Human Parainfluenza Virus Type 3 49
Piv3 49

Classifications:



Summaries for Parainfluenza Virus Type 3

NIH Rare Diseases : 49 Parainfluenza virus type 3 is one of a group of common viruses known as human parainfluenza viruses (HPIV) that cause a variety of respiratory illnesses. Symptoms usually develop between 2 and 7 days from the time of exposure and typically resolve in 7-10 days. Symptoms may include fever, runny nose, and cough. HPIV-3 can also cause bronchiolitis, bronchitis, and pneumonia. Infants and young children are particularly susceptible to HPIV-3 infections, though older adults and those with a weakened immune system are also at risk for complications. HPIVs are usually spread from an infected person to others through coughing, sneezing, and/or touching. There is currently no vaccine to protect against parainfluenza virus infections. Most HPIV infections resolve on their own and do not require special treatment, though medical intervention may be necessary for severe breathing problems. Most adults have antibodies against parainfluenza but can get repeat infections. Last updated: 8/30/2016

MalaCards based summary : Parainfluenza Virus Type 3, also known as human parainfluenza virus type 3, is related to respiratory syncytial virus infectious disease and newcastle disease. An important gene associated with Parainfluenza Virus Type 3 is ZNF17 (Zinc Finger Protein 17), and among its related pathways/superpathways are Metabolism of proteins and Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF). The drugs Glutamic Acid and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Parainfluenza Virus Type 3

Graphical network of the top 20 diseases related to Parainfluenza Virus Type 3:



Diseases related to Parainfluenza Virus Type 3

Symptoms & Phenotypes for Parainfluenza Virus Type 3

GenomeRNAi Phenotypes related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

25 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 10 EIF3G
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 10 ARCN1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 10 EIF3G
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 10 COPA
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 10 ARCN1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 10 COPA
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 10 ARCN1 EIF3G
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 10 ARCN1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 10 EIF3G
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 10 ARCN1 COPA EIF3G
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 10 ARCN1
12 Decreased IL-8 secretion GR00386-A-2 9.88 IFNB1 NEU1 ARCN1 COPA EIF3G
13 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 9.86 ARCN1 COPA EIF3G HSPA9
14 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 9.86 ARCN1 COPA EIF3G HSPA9
15 Decreased Hepatitis C virus replication GR00180-A-1 9.81 ARCN1 COPA
16 Decreased Hepatitis C virus replication GR00180-A-2 9.81 ARCN1 COPA
17 Decreased human parainfluenza virus type 3 (HPIV3) infection GR00241-A-4 9.8 ARCN1 COPA EIF3G HSPA9
18 Decreased influenza A/WSN/33 replication GR00195-A-1 9.61 ARCN1 COPA EIF3G
19 Decreased lymphocytic choriomeningitis virus (LCMV) infection GR00241-A-3 9.58 EIF3G ARCN1 COPA
20 Decreased influenza A H1N1 (A/WSN/33) virus numbers GR00195-A-2 9.46 EIF3G COPA
21 Decreased Salmonella enterica Typhimurium binding GR00133-A-3 9.37 ARCN1 COPA
22 Decreased Salmonella enterica Typhimurium ruffling GR00133-A-5 9.32 ARCN1 COPA
23 Decreased Salmonella-containing vacuole maturation GR00133-A-2 9.26 ARCN1 COPA
24 Increased G1 DNA content GR00098-A-1 9.02 ARCN1 COPA EIF3G HSPA9 NEU1

Drugs & Therapeutics for Parainfluenza Virus Type 3

Drugs for Parainfluenza Virus Type 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glutamic Acid Approved, Nutraceutical Phase 1, Phase 2 56-86-0 33032
2 Vaccines Phase 1, Phase 2
3 Krestin Phase 1

Interventional clinical trials:

(show all 13)

# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine-like Viral Shedding of MEDI-534, Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3), in Healthy 6 to <24 Month-old Children and in 2 Month-old Infants Completed NCT00686075 Phase 1, Phase 2
2 A Phase 1/2A Study to Evaluate the Safety, Immunogenicity, and Shedding of MEDI-560 in Infants 1 to < 12 Months of Age Terminated NCT00508651 Phase 1, Phase 2
3 Evaluating the Safety of and Immune Response to a Human Parainfluenza Virus Type 3 Ebola Virus Vaccine (HPIV3-EbovZ GP) in Healthy Adults Completed NCT02564575 Phase 1
4 Evaluating the Safety and Immunogenicity of a Human Parainfluenza Type 3 (HPIV3) Virus Vaccine in Infants and Children Completed NCT01254175 Phase 1
5 Safety of and Immune Response to a Cow/Human Parainfluenza Virus Vaccine (rB/HPIV3) in Healthy Infants, Children, and Adults Completed NCT00366782 Phase 1
6 Study to Evaluate the Safety of MEDI-534 Vaccine Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3) in Healthy Children Completed NCT00345670 Phase 1
7 Safety and Tolerability Study to Evaluate MEDI-534 in Children 6 to < 24 Months of Age Completed NCT00493285 Phase 1
8 Safety of and Immune Response to Recombinant Live Attenuated Parainfluenza Type 3 Virus Vaccine in Healthy Infants and Children Completed NCT01021397 Phase 1 rHPIV3cp45;rHPIV3cp45 placebo
9 Safety of and Immune Response to a Human Parainfluenza Virus Vaccine (rHPIV3cp45) in Healthy Infants Completed NCT00308412 Phase 1
10 Study to Evaluate MEDI-534 in Healthy Adults Completed NCT00111878 Phase 1 MEDI-534
11 Safety, Reactogenicity, and Immunogenicity of mRNA-1653 in Healthy Adults Recruiting NCT03392389 Phase 1
12 T-Lymphocytes for Prevention or Treatment of Viral Infections Following Hematopoietic Stem Cell Transplantation Recruiting NCT03180216 Phase 1
13 Evaluating the Live-Attenuated Human Parainfluenza Virus Type 3 Vectored Vaccine Candidate Expressing Ebolavirus Zaire Glycoprotein as the Sole Envelope Glycoprotein Recruiting NCT03462004 Phase 1

Search NIH Clinical Center for Parainfluenza Virus Type 3

Genetic Tests for Parainfluenza Virus Type 3

Anatomical Context for Parainfluenza Virus Type 3

MalaCards organs/tissues related to Parainfluenza Virus Type 3:

38
Lung, T Cells, Testes, Monocytes, Bone Marrow, Liver, Bone

Publications for Parainfluenza Virus Type 3

Articles related to Parainfluenza Virus Type 3:

(show top 50) (show all 289)
# Title Authors Year
1
Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein. ( 29187536 )
2018
2
Cholesterol-rich lipid rafts play a critical role in bovine parainfluenza virus type 3 (BPIV3) infection. ( 28654867 )
2017
3
A single L288I substitution in the fusion protein of bovine parainfluenza virus type 3 enhances virus growth in semi-suitable cell lines. ( 28451903 )
2017
4
Genetic analysis of human parainfluenza virus type 3 obtained in Croatia, 2011-2015. ( 28463659 )
2017
5
The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses. ( 28407488 )
2017
6
Inclusion Body Fusion of Human Parainfluenza Virus Type 3 Regulated by Acetylated I+-Tubulin Enhances Viral Replication. ( 27881643 )
2017
7
Complete Genome Sequences of Two Human Parainfluenza Virus Type 3 Isolates Collected in Brazil. ( 29217788 )
2017
8
Identification of candidate protein markers of Bovine Parainfluenza Virus Type 3 infection using an in vitro model. ( 28619153 )
2017
9
Human parainfluenza virus type 3 infections in hematopoietic stem cell transplantation patients: The mode of nosocomial infections and the prognosis. ( 29279454 )
2017
10
Development of a blocking ELISA for Caprine parainfluenza virus type 3. ( 28966036 )
2017
11
Parainfluenza virus type 3 outbreak in a neonatal intensive care unit. ( 29359411 )
2017
12
Vaccination with a human parainfluenza virus type 3 chimeric FHN glycoprotein formulated with a combination adjuvant induces protective immunity. ( 29153777 )
2017
13
Reciprocal complementation of bovine parainfluenza virus type 3 lacking either the membrane or fusion gene. ( 28842134 )
2017
14
A molecular epidemiological study of human parainfluenza virus type 3 at a tertiary university hospital during 2013-2015 in Catalonia, Spain. ( 27524509 )
2016
15
Viral Protein Requirements for Assembly and Release of Human Parainfluenza Virus Type 3 Virus-Like Particles. ( 26960133 )
2016
16
Rapid detection of novel caprine parainfluenza virus type 3 (CPIV3) using a TaqMan-based RT-qPCR. ( 27448824 )
2016
17
Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3. ( 27707917 )
2016
18
Pathogenicity and horizontal transmission studies of caprine parainfluenza virus type 3 JS2013 strain in goats. ( 27374058 )
2016
19
A parainfluenza virus type 3 outbreak at a residential aged care facility: The role of microbiologic testing in early identification and antimicrobial stewardship. ( 27665033 )
2016
20
The aberrant gene-end transcription signal of the matrix M gene of human parainfluenza virus type 3 downregulates fusion F protein expression and the F-specific antibody response in vivo. ( 25589643 )
2015
21
Infection of the upper respiratory tract of hamsters by the bovine parainfluenza virus type 3 BN-1 strain expressing enhanced green fluorescent protein. ( 25543964 )
2015
22
Interaction of Human Parainfluenza Virus Type 3 Nucleoprotein with Matrix Protein Mediates Internal Viral Protein Assembly. ( 26656716 )
2015
23
Catalytic mechanism and novel receptor binding sites of human parainfluenza virus type 3 hemagglutinin-neuraminidase (hPIV3 HN). ( 26364554 )
2015
24
Mutations in the DI-DII Linker of Human Parainfluenza Virus Type 3 Fusion Protein Result in Diminished Fusion Activity. ( 26305905 )
2015
25
Epidemiology and clinical outcome of lower respiratory tract infections by respiratory syncytial virus or parainfluenza virus type 3 in adults receiving treatment for either acute leukemia or severe aplastic anemia: a retrospective single center study. ( 26204825 )
2015
26
Human parainfluenza virus type 3 (HPIV3) induces production of IFNI^ and RANTES in human nasal epithelial cells (HNECs). ( 25722655 )
2015
27
Identification of three antigen epitopes on the nucleocapsid protein of the genotype C of bovine parainfluenza virus type 3. ( 25960335 )
2015
28
Development and evaluation of two truncated recombinant NP antigen-based indirect ELISAs for detection of bovine parainfluenza virus type 3 antibodies in cattle. ( 26031225 )
2015
29
Amino acid substitutions contributing to I+2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase. ( 25871520 )
2015
30
Phosphoprotein of human parainfluenza virus type 3 blocks autophagosome-lysosome fusion to increase virus production. ( 24832451 )
2014
31
Complete genome sequence of the first isolate of genotype C bovine parainfluenza virus type 3 in Japan. ( 25428970 )
2014
32
Wheat germ cell-free system-based production of hemagglutinin-neuraminidase glycoprotein of human parainfluenza virus type 3 for generation and characterization of monoclonal antibody. ( 24860558 )
2014
33
A novel parainfluenza virus type 3 (PIV3) identified from goat herds with respiratory diseases in eastern China. ( 25236986 )
2014
34
Parainfluenza virus type 3 Ab in allogeneic hematopoietic cell transplant recipients: factors influencing post-transplant Ab titers and associated outcomes. ( 24978141 )
2014
35
Molecular evolution of the haemagglutinin-neuraminidase gene in human parainfluenza virus type 3 isolates from children with acute respiratory illness in Yamagata prefecture, Japan. ( 24464692 )
2014
36
Chimeric bovine/human parainfluenza virus type 3 expressing respiratory syncytial virus (RSV) F glycoprotein: effect of insert position on expression, replication, immunogenicity, stability, and protection against RSV infection. ( 24478424 )
2014
37
Pathogenesis of a genotype C strain of bovine parainfluenza virus type 3 infection in albino guinea pigs. ( 24681303 )
2014
38
A leucine residue in the C terminus of human parainfluenza virus type 3 matrix protein is essential for efficient virus-like particle and virion release. ( 25187547 )
2014
39
Influence of antigen insertion site and vector dose on immunogenicity and protective capacity in Sendai virus-based human parainfluenza virus type 3 vaccines. ( 23514887 )
2013
40
Deletion of the D domain of the human parainfluenza virus type 3 (HPIV3) PD protein results in decreased viral RNA synthesis and beta interferon (IFN-I^) expression. ( 23686695 )
2013
41
Development of oligomannose-coated liposome-based nasal vaccine against human parainfluenza virus type 3. ( 24324462 )
2013
42
Seasonal patterns of respiratory syncytial virus, influenza A virus, human metapneumovirus, and parainfluenza virus type 3 infections on the basis of virus isolation data between 2004 and 2011 in Yamagata, Japan. ( 23514911 )
2013
43
Parainfluenza virus type 3 outbreak in a neonatal nursery. ( 22511200 )
2013
44
Prevalence of antibodies against Parainfluenza virus type 3, Respiratory syncitial virus and bovine Herpesvirus type 1 in sheep from Northern Prefectures of Japan. ( 24166480 )
2013
45
An amino acid of human parainfluenza virus type 3 nucleoprotein is critical for template function and cytoplasmic inclusion body formation. ( 24027324 )
2013
46
Role of N-linked glycosylation of the human parainfluenza virus type 3 hemagglutinin-neuraminidase protein. ( 23562646 )
2013
47
Human parainfluenza virus type 3 in wild nonhuman primates, Zambia. ( 23968816 )
2013
48
Complete Genome Sequences of Bovine Parainfluenza Virus Type 3 Strain BN-1 and Vaccine Strain BN-CE. ( 23469358 )
2013
49
Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3. ( 24235828 )
2013
50
Molecular characterization of a Korean bovine parainfluenza virus type 3 isolate. ( 23140940 )
2013

Variations for Parainfluenza Virus Type 3

Expression for Parainfluenza Virus Type 3

Search GEO for disease gene expression data for Parainfluenza Virus Type 3.

Pathways for Parainfluenza Virus Type 3

Pathways related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 ARCN1 COPA EIF3G HSPA9 NEU1
2 10 ARCN1 COPA

GO Terms for Parainfluenza Virus Type 3

Cellular components related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transport vesicle GO:0030133 9.16 ARCN1 COPA
2 COPI-coated vesicle membrane GO:0030663 8.96 ARCN1 COPA
3 COPI vesicle coat GO:0030126 8.62 ARCN1 COPA

Biological processes related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retrograde vesicle-mediated transport, Golgi to ER GO:0006890 8.62 ARCN1 COPA

Sources for Parainfluenza Virus Type 3

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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32 ICD10
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65 SNOMED-CT via HPO
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67 TGDB
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70 UMLS via Orphanet
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