PIV3
MCID: PRN029
MIFTS: 31

Parainfluenza Virus Type 3 (PIV3) malady

Categories: Rare diseases

Aliases & Classifications for Parainfluenza Virus Type 3

Aliases & Descriptions for Parainfluenza Virus Type 3:

Name: Parainfluenza Virus Type 3 50
Human Parainfluenza Virus Type 3 50
Piv3 50

Classifications:



Summaries for Parainfluenza Virus Type 3

NIH Rare Diseases : 50 parainfluenza virus type 3 is one of a group of common viruses known as human parainfluenza viruses (hpiv) that cause a variety of respiratory illnesses. symptoms usually develop between 2 and 7 days from the time of exposure and typically resolve in 7-10 days. symptoms may include fever, runny nose, and cough. hpiv-3 can also cause bronchiolitis, bronchitis, and pneumonia. infants and young children are particularly susceptible to hpiv-3 infections, though older adults and those with a weakened immune system are also at risk for complications. hpivs are usually spread from an infected person to others through coughing, sneezing, and/or touching. there is currently no vaccine to protect against parainfluenza virus infections. most hpiv infections resolve on their own and do not require special treatment, though medical intervention may be necessary for severe breathing problems. most adults have antibodies against parainfluenza but can get repeat infections. last updated: 8/30/2016

MalaCards based summary : Parainfluenza Virus Type 3, also known as human parainfluenza virus type 3, is related to fetal parainfluenza virus type 3 syndrome and pneumonia. An important gene associated with Parainfluenza Virus Type 3 is NEU1 (Neuraminidase 1), and among its related pathways/superpathways is Type II interferon signaling (IFNG). The drugs Cholecalciferol and Ergocalciferol have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related phenotypes are Decreased human parainfluenza virus type 3 (HPIV3) infection and Decreased lymphocytic choriomeningitis virus (LCMV) infection

Related Diseases for Parainfluenza Virus Type 3

Diseases related to Parainfluenza Virus Type 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
id Related Disease Score Top Affiliating Genes
1 fetal parainfluenza virus type 3 syndrome 12.1
2 pneumonia 10.3
3 influenza 10.1
4 mucositis 10.1
5 vaccinia 10.1
6 severe acute respiratory syndrome 10.1 IFNB1 NEU1
7 meningitis 10.0
8 hypercementosis 9.9 IFNB1 NEU1
9 hydrocephalus 9.9
10 measles 9.9
11 pertussis 9.9
12 diarrhea 9.9
13 aplastic anemia 9.8
14 acute leukemia 9.8
15 herpes simplex 9.8
16 leukemia 9.8
17 swine influenza 9.8
18 parotitis 9.8
19 stevens-johnson syndrome/toxic epidermal necrolysis 9.8
20 meningoencephalitis 9.8
21 congenital hydrocephalus 9.8
22 aseptic meningitis 9.8
23 bronchopneumonia 9.8
24 urethritis 9.8
25 newcastle disease 9.8
26 bronchiolitis 9.8
27 parkinson disease type 9 8.9 CIITA COPA DCAF13 GAPDH IFNB1 NEU1

Graphical network of the top 20 diseases related to Parainfluenza Virus Type 3:



Diseases related to Parainfluenza Virus Type 3

Symptoms & Phenotypes for Parainfluenza Virus Type 3

GenomeRNAi Phenotypes related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human parainfluenza virus type 3 (HPIV3) infection GR00241-A-4 9.16 COPA DCAF13
2 Decreased lymphocytic choriomeningitis virus (LCMV) infection GR00241-A-3 8.96 COPA DCAF13
3 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 8.92 COPA DCAF13
4 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 8.92 COPA DCAF13

Drugs & Therapeutics for Parainfluenza Virus Type 3

Drugs for Parainfluenza Virus Type 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cholecalciferol Approved, Nutraceutical Phase 3 67-97-0 6221 10883523 5280795
2
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
3 vitamin d Phase 3
4 Trace Elements Phase 3
5 Ergocalciferols Phase 3
6 Vitamins Phase 3
7 Micronutrients Phase 3
8 Bone Density Conservation Agents Phase 3
9 Vitamin D2 Nutraceutical Phase 3
10 Calciferol Nutraceutical Phase 3
11 Vaccines Phase 1, Phase 2
12 Glutamic Acid Nutraceutical Phase 1, Phase 2
13 Krestin Phase 1

Interventional clinical trials:

(show all 15)
id Name Status NCT ID Phase
1 Maternal Vitamin D for Acute Respiratory Infections in Infancy Completed NCT02388516 Phase 3
2 A Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine-like Viral Shedding of MEDI-534, Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3), in Healthy 6 to <24 Month-old Children and in 2 Month-old Infants Completed NCT00686075 Phase 1, Phase 2
3 A Phase 1/2A Study to Evaluate the Safety, Immunogenicity, and Shedding of MEDI-560 in Infants 1 to < 12 Months of Age Terminated NCT00508651 Phase 1, Phase 2
4 Evaluating the Safety of and Immune Response to a Human Parainfluenza Virus Type 3 Ebola Virus Vaccine (HPIV3-EbovZ GP) in Healthy Adults Completed NCT02564575 Phase 1
5 Study to Evaluate the Safety of MEDI-534 Vaccine Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3) in Healthy Children Completed NCT00345670 Phase 1
6 Evaluating the Safety and Immunogenicity of a Human Parainfluenza Type 3 (HPIV3) Virus Vaccine in Infants and Children Completed NCT01254175 Phase 1
7 Safety of and Immune Response to a Cow/Human Parainfluenza Virus Vaccine (rB/HPIV3) in Healthy Infants, Children, and Adults Completed NCT00366782 Phase 1
8 Safety and Tolerability Study to Evaluate MEDI-534 in Children 6 to < 24 Months of Age Completed NCT00493285 Phase 1
9 Safety of and Immune Response to Recombinant Live Attenuated Parainfluenza Type 3 Virus Vaccine in Healthy Infants and Children Completed NCT01021397 Phase 1
10 Safety of and Immune Response to a Human Parainfluenza Virus Vaccine (rHPIV3cp45) in Healthy Infants Completed NCT00308412 Phase 1
11 Study to Evaluate MEDI-534 in Healthy Adults Completed NCT00111878 Phase 1
12 Safety of and Immune Response to Recombinant Live-Attenuated Parainfluenza Type 1 Virus Vaccine Completed NCT00641017 Phase 1
13 T-Lymphocytes for Prevention or Treatment of Viral Infections Following Hematopoietic Stem Cell Transplantation Recruiting NCT03180216 Phase 1
14 A Study to Assess the Safety of Live Intranasal Sendai Virus Vaccine in Children and Toddlers Recruiting NCT00186927 Phase 1
15 Collection and Testing of Respiratory Samples Completed NCT01302418

Search NIH Clinical Center for Parainfluenza Virus Type 3

Genetic Tests for Parainfluenza Virus Type 3

Anatomical Context for Parainfluenza Virus Type 3

MalaCards organs/tissues related to Parainfluenza Virus Type 3:

39
Lung, T Cells, Testes, Monocytes, Bone, Liver, Bone Marrow

Publications for Parainfluenza Virus Type 3

Articles related to Parainfluenza Virus Type 3:

(show top 50) (show all 277)
id Title Authors Year
1
Inclusion Body Fusion of Human Parainfluenza Virus Type 3 Regulated by Acetylated I+-Tubulin Enhances Viral Replication. ( 27881643 )
2017
2
A parainfluenza virus type 3 outbreak at a residential aged care facility: The role of microbiologic testing in early identification and antimicrobial stewardship. ( 27665033 )
2016
3
Rapid detection of novel caprine parainfluenza virus type 3 (CPIV3) using a TaqMan-based RT-qPCR. ( 27448824 )
2016
4
Viral Protein Requirements for Assembly and Release of Human Parainfluenza Virus Type 3 Virus-Like Particles. ( 26960133 )
2016
5
Pathogenicity and horizontal transmission studies of caprine parainfluenza virus type 3 JS2013 strain in goats. ( 27374058 )
2016
6
Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3. ( 27707917 )
2016
7
A molecular epidemiological study of human parainfluenza virus type 3 at a tertiary university hospital during 2013-2015 in Catalonia, Spain. ( 27524509 )
2016
8
Epidemiology and clinical outcome of lower respiratory tract infections by respiratory syncytial virus or parainfluenza virus type 3 in adults receiving treatment for either acute leukemia or severe aplastic anemia: a retrospective single center study. ( 26204825 )
2015
9
Mutations in the DI-DII Linker of Human Parainfluenza Virus Type 3 Fusion Protein Result in Diminished Fusion Activity. ( 26305905 )
2015
10
Amino acid substitutions contributing to I+2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase. ( 25871520 )
2015
11
Catalytic mechanism and novel receptor binding sites of human parainfluenza virus type 3 hemagglutinin-neuraminidase (hPIV3 HN). ( 26364554 )
2015
12
The aberrant gene-end transcription signal of the matrix M gene of human parainfluenza virus type 3 downregulates fusion F protein expression and the F-specific antibody response in vivo. ( 25589643 )
2015
13
Identification of three antigen epitopes on the nucleocapsid protein of the genotype C of bovine parainfluenza virus type 3. ( 25960335 )
2015
14
Development and evaluation of two truncated recombinant NP antigen-based indirect ELISAs for detection of bovine parainfluenza virus type 3 antibodies in cattle. ( 26031225 )
2015
15
Human parainfluenza virus type 3 (HPIV3) induces production of IFNI^ and RANTES in human nasal epithelial cells (HNECs). ( 25722655 )
2015
16
Interaction of Human Parainfluenza Virus Type 3 Nucleoprotein with Matrix Protein Mediates Internal Viral Protein Assembly. ( 26656716 )
2015
17
Infection of the upper respiratory tract of hamsters by the bovine parainfluenza virus type 3 BN-1 strain expressing enhanced green fluorescent protein. ( 25543964 )
2015
18
Parainfluenza virus type 3 Ab in allogeneic hematopoietic cell transplant recipients: factors influencing post-transplant Ab titers and associated outcomes. ( 24978141 )
2014
19
Complete genome sequence of the first isolate of genotype C bovine parainfluenza virus type 3 in Japan. ( 25428970 )
2014
20
Wheat germ cell-free system-based production of hemagglutinin-neuraminidase glycoprotein of human parainfluenza virus type 3 for generation and characterization of monoclonal antibody. ( 24860558 )
2014
21
A leucine residue in the C terminus of human parainfluenza virus type 3 matrix protein is essential for efficient virus-like particle and virion release. ( 25187547 )
2014
22
Phosphoprotein of human parainfluenza virus type 3 blocks autophagosome-lysosome fusion to increase virus production. ( 24832451 )
2014
23
Molecular evolution of the haemagglutinin-neuraminidase gene in human parainfluenza virus type 3 isolates from children with acute respiratory illness in Yamagata prefecture, Japan. ( 24464692 )
2014
24
A novel parainfluenza virus type 3 (PIV3) identified from goat herds with respiratory diseases in eastern China. ( 25236986 )
2014
25
Chimeric bovine/human parainfluenza virus type 3 expressing respiratory syncytial virus (RSV) F glycoprotein: effect of insert position on expression, replication, immunogenicity, stability, and protection against RSV infection. ( 24478424 )
2014
26
Pathogenesis of a genotype C strain of bovine parainfluenza virus type 3 infection in albino guinea pigs. ( 24681303 )
2014
27
Influence of antigen insertion site and vector dose on immunogenicity and protective capacity in Sendai virus-based human parainfluenza virus type 3 vaccines. ( 23514887 )
2013
28
Complete Genome Sequences of Bovine Parainfluenza Virus Type 3 Strain BN-1 and Vaccine Strain BN-CE. ( 23469358 )
2013
29
Human parainfluenza virus type 3 in wild nonhuman primates, Zambia. ( 23968816 )
2013
30
Development of oligomannose-coated liposome-based nasal vaccine against human parainfluenza virus type 3. ( 24324462 )
2013
31
Prevalence of antibodies against Parainfluenza virus type 3, Respiratory syncitial virus and bovine Herpesvirus type 1 in sheep from Northern Prefectures of Japan. ( 24166480 )
2013
32
Deletion of the D domain of the human parainfluenza virus type 3 (HPIV3) PD protein results in decreased viral RNA synthesis and beta interferon (IFN-I^) expression. ( 23686695 )
2013
33
Parainfluenza virus type 3 outbreak in a neonatal nursery. ( 22511200 )
2013
34
Role of N-linked glycosylation of the human parainfluenza virus type 3 hemagglutinin-neuraminidase protein. ( 23562646 )
2013
35
An amino acid of human parainfluenza virus type 3 nucleoprotein is critical for template function and cytoplasmic inclusion body formation. ( 24027324 )
2013
36
Molecular characterization of a Korean bovine parainfluenza virus type 3 isolate. ( 23140940 )
2013
37
Seasonal patterns of respiratory syncytial virus, influenza A virus, human metapneumovirus, and parainfluenza virus type 3 infections on the basis of virus isolation data between 2004 and 2011 in Yamagata, Japan. ( 23514911 )
2013
38
Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3. ( 24235828 )
2013
39
Isolation and characterization of bovine parainfluenza virus type 3 from water buffaloes (Bubalus bubalis) in Argentina. ( 22716217 )
2012
40
Molecular characterization and phylogenetic analysis of human parainfluenza virus type 3 isolated from Saudi Arabia. ( 22711360 )
2012
41
Studies on the pathogenesis of a Chinese strain of bovine parainfluenza virus type 3 infection in Balb/c mice. ( 22391217 )
2012
42
Phylogenetic analysis of the bovine parainfluenza virus type 3 from cattle herds revealing the existence of a genotype A strain in China. ( 22923090 )
2012
43
Mutations within the human parainfluenza virus type 3 (HPIV 3) C protein affect viral replication and host interferon induction. ( 22634035 )
2012
44
Evaluation of two chimeric bovine-human parainfluenza virus type 3 vaccines in infants and young children. ( 22178099 )
2012
45
Phase 1 study of the safety and immunogenicity of a live, attenuated respiratory syncytial virus and parainfluenza virus type 3 vaccine in seronegative children. ( 21926667 )
2012
46
Impact of parainfluenza virus type 3 infection on engraftment after hematopoietic SCT. ( 21478915 )
2012
47
Sulfatide negatively regulates the fusion process of human parainfluenza virus type 3. ( 22821828 )
2012
48
Human parainfluenza virus type 3 (HPIV 3) viral community-acquired pneumonia (CAP) mimicking swine influenza (H1N1) during the swine flu pandemic. ( 20888645 )
2011
49
Analysis of nucleotides 13-96 of the human parainfluenza virus type 3 antigenomic promoter reveals positive- and negative-acting replication elements. ( 21880340 )
2011
50
Human parainfluenza virus type 3 (HPIV 3) community-acquired pneumonia (CAP) mimicking pertussis in an adult: the diagnostic importance of hoarseness and monocytosis. ( 20888644 )
2011

Variations for Parainfluenza Virus Type 3

Expression for Parainfluenza Virus Type 3

Search GEO for disease gene expression data for Parainfluenza Virus Type 3.

Pathways for Parainfluenza Virus Type 3

Pathways related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.19 CIITA IFNB1

GO Terms for Parainfluenza Virus Type 3

Biological processes related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular response to interferon-gamma GO:0071346 8.96 CIITA GAPDH
2 cellular response to exogenous dsRNA GO:0071360 8.62 CIITA IFNB1

Sources for Parainfluenza Virus Type 3

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68 Tocris
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70 UMLS via Orphanet
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