MCID: PRN029
MIFTS: 41

Parainfluenza Virus Type 3 malady

Rare diseases category

Aliases & Classifications for Parainfluenza Virus Type 3

About this section

Parainfluenza Virus Type 3, Aliases & Descriptions:

Name: Parainfluenza Virus Type 3 41
Human Parainfluenza Virus Type 3 41
 
Piv3 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Summaries for Parainfluenza Virus Type 3

About this section


MalaCards based summary: Parainfluenza Virus Type 3, also known as human parainfluenza virus type 3, is related to measles and newcastle disease. An important gene associated with Parainfluenza Virus Type 3 is NEU1 (sialidase 1 (lysosomal sialidase)), and among its related pathways are Cytokines and Inflammatory Response and Immune response MIF mediated glucocorticoid regulation. The compounds rebif and avonex have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and bone marrow, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Related Diseases for Parainfluenza Virus Type 3

About this section

Diseases related to Parainfluenza Virus Type 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1measles30.9MX1, IFNB1, STAT1, RNPC3
2newcastle disease30.8NEU1, IFNA1, IFNB1
3herpes simplex29.8RNASEL, NEU1, STAT1, IFNA1, IFNB1, CRAT
4influenza29.5MX1, EIF2AK2, CRAT, ZNF17, IFIH1, IFNB1
5pneumonia10.8
6vaccinia10.6
7venezuelan equine encephalitis10.6FURIN
8meningitis10.5
9fetal parainfluenza virus type 3 syndrome10.5
10chronic inflammatory demyelinating polyradiculoneuropathy10.5IFNB1
11rift valley fever10.5MX1
12hydrocephalus10.4
13diarrhea10.4
14pertussis10.4
15hemophagocytic lymphohistiocytosis10.4IFNB1, MX1
16rabies10.4MX1, RNPC3
17dengue disease10.4RNASEL, NEU1, IFNB1
18chronic fatigue syndrome10.3EIF2AK2, RNASEL
19urethritis10.3
20bronchiolitis10.3
21meningoencephalitis10.3
22parotitis10.3
23swine influenza10.3
24aseptic meningitis10.3
25bronchopneumonia10.3
26blindness10.3
27congenital hydrocephalus10.3
28subacute sclerosing panencephalitis10.3MX1, IFNA1
29mumps10.2EIF2AK2, STAT1, NEU1
30dermatomyositis10.2MX1, ICAM1
31thyroiditis10.2IFNA1
32hypothyroidism10.2IFNA1, IFNB1
33myocarditis10.2IFNB1
34henoch-schoenlein purpura10.2ICAM1, MX1
35acute erythroid leukemia10.2CRAT, IFNB1, STAT1
36adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency10.2IFNA1, IFNB1
37cervical cancer, somatic10.2CRAT, IFNB1, STAT1
38hepatitis10.2STAT1, IFNA1, IFNB1
39tropical spastic paraparesis10.1IL2, IFNB1
40allergic asthma10.1IFNB1, STAT1, ICAM1
41down syndrome10.1GAPDH, MX1, NCL
42viral hepatitis10.1MX1, IFNB1, IFNA1, STAT1
43malaria10.0GAPDH, ICAM1, NEU1
44iga glomerulonephritis10.0GAPDH, ICAM1, NEU1
45malignant glioma10.0FURIN, NEU1, STAT1, IFNB1, CRAT
46choriocarcinoma10.0STAT1, CRAT, GAPDH
47lichen planus10.0ICAM1, MX1
48hepatitis d10.0RNPC3, IFNA1, NCL, EIF2AK2
49sezary's disease10.0IL2, IFNA1
50hcl-v10.0IFNA1, IFNB1, IL2

Graphical network of the top 20 diseases related to Parainfluenza Virus Type 3:



Diseases related to parainfluenza virus type 3

Symptoms for Parainfluenza Virus Type 3

About this section

Drugs & Therapeutics for Parainfluenza Virus Type 3

About this section

Drug clinical trials:

Search ClinicalTrials for Parainfluenza Virus Type 3

Search NIH Clinical Center for Parainfluenza Virus Type 3

Genetic Tests for Parainfluenza Virus Type 3

About this section

Anatomical Context for Parainfluenza Virus Type 3

About this section

MalaCards organs/tissues related to Parainfluenza Virus Type 3:

31
Lung, T cells, Bone marrow, Bone, Liver, Testes, Monocytes

Animal Models for Parainfluenza Virus Type 3 or affiliated genes

About this section

MGI Mouse Phenotypes related to Parainfluenza Virus Type 3:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7DDX58, ICAM1, STAT1, IFNB1, IL2, EIF2AK2
2MP:00053708.4DDX58, FURIN, NEU1, STAT1, IL2, GAPDH
3MP:00053847.9DDX58, RNASEL, NEU1, ICAM1, STAT1, IFIH1
4MP:00053857.8FURIN, NEU1, ICAM1, STAT1, IL2, CRAT
5MP:00053787.7FURIN, NEU1, ICAM1, STAT1, IL2, CRAT
6MP:00053877.2NEU1, RNASEL, FURIN, DDX58, PRKCZ, ICAM1
7MP:00107687.0DDX58, FURIN, NEU1, ICAM1, STAT1, IFIH1
8MP:00053767.0ICAM1, PRKCZ, NEU1, DDX58, STAT1, IFNB1
9MP:00053976.7GAPDH, DDX58, FURIN, RNASEL, NEU1, PRKCZ

Publications for Parainfluenza Virus Type 3

About this section

Articles related to Parainfluenza Virus Type 3:

(show top 50)    (show all 262)
idTitleAuthorsYear
1
Phosphoprotein of human parainfluenza virus type 3 blocks autophagosome-lysosome fusion to increase virus production. (24832451)
2014
2
Chimeric bovine/human parainfluenza virus type 3 expressing respiratory syncytial virus (RSV) F glycoprotein: effect of insert position on expression, replication, immunogenicity, stability, and protection against RSV infection. (24478424)
2014
3
Prevalence of antibodies against Parainfluenza virus type 3, Respiratory syncitial virus and bovine Herpesvirus type 1 in sheep from Northern Prefectures of Japan. (24166480)
2013
4
Comparison of differing cytopathic effects in human airway epithelium of parainfluenza virus 5 (W3A), parainfluenza virus type 3, and respiratory syncytial virus. (21986028)
2011
5
Identification of simian agent 10 as human parainfluenza virus type 3 suggests transmission of a human virus to an African monkey. (20881043)
2010
6
Phosphoprotein, P of human parainfluenza virus type 3 prevents self-association of RNA-dependent RNA polymerase, L. (19012944)
2009
7
Evidence for phosphorylation of human parainfluenza virus type 3 C protein: mutant C proteins exhibit variable inhibitory activities in vitro. (19410612)
2009
8
Natural killer cells regulate T-cell proliferation during human parainfluenza virus type 3 infection. (18614637)
2008
9
Molecular investigations of an outbreak of parainfluenza virus type 3 and respiratory syncytial virus infections in a hematology unit. (17392447)
2007
10
A chimeric alphavirus RNA replicon gene-based vaccine for human parainfluenza virus type 3 induces protective immunity against intranasal virus challenge. (17052811)
2007
11
Roles of human parainfluenza virus type 3 bases 13 to 78 in replication and transcription: identification of an additional replication promoter element and evidence for internal transcription initiation. (16699019)
2006
12
Interferon action against human parainfluenza virus type 3: involvement of a novel antiviral pathway in the inhibition of transcription. (11312354)
2001
13
Human parainfluenza virus type 3 HN-receptor interaction: effect of 4-guanidino-Neu5Ac2en on a neuraminidase-deficient variant. (11462020)
2001
14
A single amino acid substitution in the viral polymerase creates a temperature-sensitive and attenuated recombinant bovine parainfluenza virus type 3. (11601905)
2001
15
Antibody responses to bovine parainfluenza virus type 3 (PIV3) vaccination and human PIV3 infection in young infants. (11509996)
2001
16
Role of NH(2)- and COOH-terminal domains of the P protein of human parainfluenza virus type 3 in transcription and replication. (10846069)
2000
17
Sequence determination and molecular analysis of two strains of bovine parainfluenza virus type 3 that are attenuated for primates. (10872880)
2000
18
Specific phosphorylated forms of glyceraldehyde 3-phosphate dehydrogenase associate with human parainfluenza virus type 3 and inhibit viral transcription in vitro. (10729139)
2000
19
Precise mapping of the replication and transcription promoters of human parainfluenza virus type 3. (10725212)
2000
20
Long nucleotide insertions between the HN and L protein coding regions of human parainfluenza virus type 3 yield viruses with temperature-sensitive and attenuation phenotypes. (10873765)
2000
21
Mutations in the C, D, and V open reading frames of human parainfluenza virus type 3 attenuate replication in rodents and primates. (10497117)
1999
22
Immune responses and protection induced by DNA vaccines encoding bovine parainfluenza virus type 3 glycoproteins. (10405354)
1999
23
Three amino acid substitutions in the L protein of the human parainfluenza virus type 3 cp45 live attenuated vaccine candidate contribute to its temperature-sensitive and attenuation phenotypes. (9499025)
1998
24
Interaction of human parainfluenza virus type 3 with the host cell surface. (9380464)
1997
25
Rescue of Sendai virus cDNA templates with cDNA clones expressing parainfluenza virus type 3 N, P and L proteins. (8887479)
1996
26
Some virological and pathomorphological aspects of the respiratory system in the experimental infection with respiratory syncytial virus associated with influenza virus, parainfluenza virus type 3 and adenovirus in the mouse. (9495783)
1996
27
Human parainfluenza virus type 3: analysis of the cytoplasmic tail and transmembrane anchor of the hemagglutinin-neuraminidase protein in promoting cell fusion. (7653094)
1995
28
Sequence variation in the haemagglutinin-neuraminidase gene of human parainfluenza virus type 3 isolates in the UK. (7781737)
1995
29
Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2. (8139055)
1994
30
A prototype recombinant vaccine against respiratory syncytial virus and parainfluenza virus type 3. (7765021)
1994
31
Parainfluenza virus type 3 and pertussis syndrome. (8244477)
1993
32
Parainfluenza virus type 3 (PIV3)-specific and non-virus-specific delayed type hypersensitivity responses in cotton rats given different PIV3 antigen preparations. (8383384)
1993
33
Isolation of parainfluenza virus type 3 from cerebrospinal fluid. (1316416)
1992
34
RNA editing in the phosphoprotein gene of the human parainfluenza virus type 3. (1310183)
1992
35
Fusion properties of cells persistently infected with human parainfluenza virus type 3: participation of hemagglutinin-neuraminidase in membrane fusion. (1851852)
1991
36
Defective interfering particles of human parainfluenza virus type 3 are associated with persistent infection in cell culture. (1649512)
1991
37
Parainfluenza virus type 3: surveillance. (1669815)
1991
38
Human parainfluenza virus type 3 transcription in vitro: role of cellular actin in mRNA synthesis. (1851877)
1991
39
Outbreak of parainfluenza virus type 3 in a neonatal nursery. (2153949)
1990
40
Antibodies to parainfluenza virus type 3 in Minnesota swine. (2849496)
1988
41
Protection of weanling hamsters from experimental infection with wild-type parainfluenza virus type 3 (para 3) by cold-adapted mutants of para 3. (3005486)
1986
42
Parainfluenza virus type 3 in pigs. (3024379)
1986
43
The effect of parainfluenza virus type 3 on the phagocytic cell response of the ovine lung to Pasteurella haemolytica. (3010545)
1986
44
Conserved structures among the nucleocapsid proteins of the paramyxoviridae: complete nucleotide sequence of human parainfluenza virus type 3 NP mRNA. (3012866)
1986
45
Properties of temperature-sensitive mutants of parainfluenza virus type 3 selected during the course of persistent infection. (2986583)
1985
46
Evidence of a T-cell-mediated cytotoxic response to parainfluenza virus type 3 pneumonia in hamsters. (6278144)
1982
47
The effect of vaccination of lambs with live parainfluenza virus type 3 on pneumonia produced by parainfluenza virus type 3 and Pasteurella haemolytica. (6258113)
1980
48
Pulmonary cell-mediated cytotoxicity in hamsters with parainfluenza virus type 3 pneumonia. (223482)
1979
49
Respiratory infection of lambs with an ovine strain parainfluenza virus type 3. (4309242)
1969
50
Cytopathic effects of parainfluenza virus Type 3 in organ cultures of human respiratory tract tissue. (4295104)
1968

Variations for Parainfluenza Virus Type 3

About this section

Expression for genes affiliated with Parainfluenza Virus Type 3

About this section
Search GEO for disease gene expression data for Parainfluenza Virus Type 3.

Pathways for genes affiliated with Parainfluenza Virus Type 3

About this section

Pathways related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL2, IFNB1
29.9ICAM1, IL2
39.6STAT1, IL2, ICAM1
49.5IFNA1, IFNB1, STAT1
59.5IFNA1, STAT1, IFNB1
69.4IFNB1, IFNA1, IL2
7
Show member pathways
IFN-gamma pathway36
9.4ICAM1, EIF2AK2, STAT1
8
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.4STAT1, IL2, EIF2AK2
9
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.2PRKCZ, IL2, STAT1
10
Show member pathways
9.2DDX58, IFNB1, IFNA1, IFIH1
11
Show member pathways
9.2IFIH1, IFNB1, IFNA1, DDX58
129.2EIF2AK2, IFNB1, STAT1, ICAM1
13
Show member pathways
Type III interferon signaling36
9.1IFNA1, IFNB1, IL2, STAT1
14
Show member pathways
Immune response CD16 signaling in NK cells58
9.1ICAM1, IFNA1, IL2, IFNB1
15
Show member pathways
9.0IFNB1, RNASEL, MX1, STAT1, IFNA1
168.8IL2, IFNB1, IFNA1, PRKCZ
17
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.6IFIH1, IFNA1, STAT1, DDX58, IL2, IFNB1
18
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
8.6EIF2AK2, STAT1, NCL, PRKCZ
19
Show member pathways
8.5IL2, IFNB1, IFNA1, STAT1, PRKCZ
208.5IFNA1, EIF2AK2, IFNB1, DDX58, STAT1, RNASEL
21
Show member pathways
7.6STAT1, RNASEL, DDX58, MX1, IFNA1, IFNB1
22
Show member pathways
7.1IFIH1, IL2, MX1, IFNB1, IFNA1, STAT1

Compounds for genes affiliated with Parainfluenza Virus Type 3

About this section

Compounds related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1rebif439.9IFNB1, IFNA1, MX1
2avonex439.9MX1, IFNA1, IFNB1
3betaseron439.9MX1, IFNB1, IFNA1
4glatiramer acetate43 1210.7IFNB1, IFNA1, IL2
5poly c439.7EIF2AK2, RNPC3, IFNB1
6acyclovir43 1210.7IFNB1, NEU1, IFNA1
7levamisole43 1210.7NEU1, IL2, IFNA1
8dacarbazine43 1210.6IFNA1, IL2, IFNB1
9imiquimod43 59 28 1212.6MX1, IFNB1, IFNA1, STAT1
10neomycin439.5CRAT, RNPC3, IFNB1, IL2
11zidovudine43 49 1211.5IL2, IFNB1, NEU1, IFNA1
12indoleamine439.5STAT1, IFNA1, IFNB1
13tetracycline43 1210.4IFNB1, FURIN, EIF2AK2, CRAT
14inosine monophosphate439.3IFNB1, EIF2AK2, IFNA1, STAT1
15temozolomide43 1210.3IFNA1, IFNB1, IL2
16neopterin439.3IFNA1, IL2, MX1, IFNB1, ICAM1
17chloroquine43 2 49 28 1213.2IFNB1, IL2, EIF2AK2, IFNA1
18rrna439.0RNPC3, RNASEL, NCL, GAPDH
19polyethylene glycol438.9GAPDH, NEU1, ICAM1, IFNA1
20poly(i-c)438.9IFNA1, STAT1, DDX58, EIF2AK2, IFNB1, MX1
21biotin43 24 1210.8STAT1, IL2, GAPDH, RNPC3
22ifn-alpha438.6RNASEL, STAT1, IFNA1, IFNB1, MX1, EIF2AK2
23retinoid438.6IFNA1, IFNB1, GAPDH, CRAT, STAT1
24pge2438.5GAPDH, ICAM1, IFNB1, STAT1, IL2, CRAT
25h2o2438.4STAT1, GAPDH, IFNB1, ICAM1, NEU1, CRAT
26tamoxifen43 49 28 1211.4IFNA1, IL2, GAPDH, CRAT, IFNB1
27dexamethasone43 49 28 1211.4STAT1, IFNA1, IFNB1, IL2, CRAT, ICAM1
28ribavirin43 49 1210.4IFNA1, IFNB1, MX1, STAT1, NEU1, RNASEL
29arginine438.4CRAT, EIF2AK2, NCL, STAT1, RNPC3, RNASEL
30adenine43 24 1210.3GAPDH, RNPC3, RNASEL, EIF2AK2, IFNB1, CRAT
31heparin43 28 24 1211.3GAPDH, NEU1, FURIN, IFNB1, NCL, EIF2AK2
32cisplatin43 49 59 1211.3IFNA1, STAT1, GAPDH, IFNB1, CRAT, IL2
33rantes438.2MX1, EIF2AK2, IFNB1, IFNA1, STAT1, ICAM1
342,5-oligoadenylate438.2CRAT, IL2, IFNB1, IFNA1, STAT1, RNASEL
35polyinosinic-polycytidylic acid438.2EIF2AK2, IL2, IFIH1, IFNB1, STAT1, CRAT
36adenylate438.1IFNB1, RNPC3, RNASEL, FURIN, GAPDH, NCL
37estrogen438.1GAPDH, NCL, CRAT, NEU1, STAT1, IFNB1
38aspartate438.1FURIN, IFNA1, EIF2AK2, IFNB1, CRAT, GAPDH
39rapamycin438.0PRKCZ, STAT1, IFNA1, IL2, GAPDH
40ly294002437.9PRKCZ, ICAM1, STAT1, IFNB1, GAPDH
41nitric oxide43 24 129.7STAT1, ICAM1, GAPDH, EIF2AK2, RNASEL, PRKCZ
42cyclosporin a43 28 599.6GAPDH, IL2, IFNA1, STAT1, ICAM1, RNPC3
43tyrosine437.6EIF2AK2, NCL, IL2, IFNB1, IFNA1, STAT1
44oligonucleotide437.6STAT1, RNASEL, RNPC3, IFNB1, CRAT, NCL
45actinomycin d437.6ICAM1, STAT1, IL2, IFNA1, IFNB1, GAPDH
46atp43 288.5MX1, RNASEL, RNPC3, STAT1, CRAT, NCL
47vegf437.4CRAT, IL2, GAPDH, IFNB1, IFNA1, STAT1
48cycloheximide436.6CRAT, IL2, IFNB1, IFNA1, STAT1, ICAM1
49retinoic acid43 247.1IFIH1, IFNA1, DDX58, NEU1, PRKCZ, NCL
50serine435.6FURIN, NEU1, PRKCZ, STAT1, IFNA1, IL2

GO Terms for genes affiliated with Parainfluenza Virus Type 3

About this section

Cellular components related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:00484718.2GAPDH, MX1, EIF2AK2, PRKCZ
2extracellular vesicular exosomeGO:00700627.5FURIN, NEU1, PRKCZ, ICAM1, NCL, GAPDH
3cytosolGO:00058297.2GAPDH, DDX58, RNASEL, PRKCZ, STAT1, IFIH1

Biological processes related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1regulation of type III interferon productionGO:003434410.2IFIH1, DDX58
2cytoplasmic pattern recognition receptor signaling pathway in response to virusGO:003952810.2IFIH1, DDX58
3detection of virusGO:000959710.2IFIH1, DDX58
4positive regulation of interferon-alpha productionGO:003272710.1DDX58, IFIH1
5response to exogenous dsRNAGO:004333010.0DDX58, STAT1, IFNB1
6natural killer cell activationGO:00301019.9IL2, IFNB1
7positive regulation of interferon-beta productionGO:00327289.9DDX58, IFIH1
8type I interferon signaling pathwayGO:00603379.8RNASEL, STAT1, IFNB1, MX1
9regulation of type I interferon-mediated signaling pathwayGO:00603389.7IFNB1, STAT1
10negative regulation of viral genome replicationGO:00450719.6RNASEL, IFNB1, EIF2AK2, MX1
11viral processGO:00160329.5IFIH1, STAT1, FURIN, DDX58
12cytokine-mediated signaling pathwayGO:00192219.5RNASEL, ICAM1, STAT1, IFNB1, MX1
13positive regulation of transcription from RNA polymerase II promoterGO:00459449.4IL2, IFNB1, STAT1, RNASEL, DDX58
14response to virusGO:00096159.3MX1, EIF2AK2, IFIH1, IFNB1, DDX58
15defense response to virusGO:00516079.3MX1, EIF2AK2, IFNB1, STAT1, RNASEL
16innate immune responseGO:00450879.2DDX58, IFNB1, IFIH1, EIF2AK2, MX1
17positive regulation of NF-kappaB transcription factor activityGO:00510929.1EIF2AK2, ICAM1, PRKCZ

Molecular functions related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1single-stranded RNA bindingGO:000372710.0IFIH1, DDX58
2double-stranded RNA bindingGO:00037259.5EIF2AK2, IFIH1, DDX58
3protein kinase activityGO:00046728.8EIF2AK2, PRKCZ, RNASEL
4identical protein bindingGO:00428028.6DDX58, STAT1, NCL, GAPDH
5protein bindingGO:00055156.5DDX58, RNASEL, PRKCZ, ICAM1, STAT1, IFIH1

Products for genes affiliated with Parainfluenza Virus Type 3

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Parainfluenza Virus Type 3

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet