PIV3
MCID: PRN029
MIFTS: 30

Parainfluenza Virus Type 3 (PIV3) malady

Summaries for Parainfluenza Virus Type 3

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33MalaCards
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MalaCards: Parainfluenza Virus Type 3, also known as human parainfluenza virus type 3, is related to vaccinia and measles. An important gene associated with Parainfluenza Virus Type 3 is NEU1 (sialidase 1 (lysosomal sialidase)), and among its related pathways are Glucocorticoid receptor regulatory network and Immune response IFN gamma signaling pathway. The compounds indoleamine and estrogen have been mentioned in the context of this disorder. Related mouse phenotypes are liver/biliary system and cellular.

Aliases & Classifications for Parainfluenza Virus Type 3

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43NIH Rare Diseases
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Aliases & Descriptions:

parainfluenza virus type 3 43
human parainfluenza virus type 3 43
piv3 43


Related Diseases for Parainfluenza Virus Type 3

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Parainfluenza Virus Type 3 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1vaccinia30.8FURIN, IL2
2measles30.5IFNB1, STAT1, RNPC3, MX1
3newcastle disease30.3NEU1, IFNB1, IFNA1
4viral pneumonia10.4
5fetal parainfluenza virus type 3 syndrome10.4
6bronchiolitis10.2
7urethritis10.2
8swine influenza10.2
9stevens-johnson syndrome10.2
10aseptic meningitis10.2
11meningoencephalitis10.2
12parotitis10.2
13n syndrome10.2
14bronchopneumonia10.2
15toxic epidermal necrolysis10.2
16guillain-barr� syndrome10.2
17cytomegalovirus infection10.2
18venezuelan equine encephalitis10.0FURIN
19nephritis10.0RNPC3
20biliary atresia10.0MX1
21lupus erythematosus10.0MX1
22rubella10.0RNPC3
23pancreatitis10.0ICAM1
24lupus nephritis10.0ICAM1
25chronic mucocutaneous candidiasis10.0STAT1
26vasculitis10.0ICAM1
27graves' disease10.0ICAM1
28dermatitis10.0ICAM1
29ebola hemorrhagic fever10.0DDX58
30hyperglycemia10.0IFNB1
31alopecia areata10.0ICAM1
32myopathy10.0CRAT
33myositis10.0ICAM1, RNPC3
34dementia10.0STAT1
35rabies10.0MX1, RNPC3
36myocarditis10.0IFNB1
37sjogren's syndrome10.0ICAM1, RNPC3
38pancreatic cancer10.0GAPDH
39polymyositis10.0ICAM1, RNPC3
40allergic rhinitis10.0ICAM1
41lichen planus10.0MX1, ICAM1
42dermatomyositis10.0MX1, ICAM1
43thyroiditis10.0IFNA1
44uveitis10.0RNPC3, ICAM1
45cystic fibrosis10.0FURIN
46papilloma10.0GAPDH
47rhinitis10.0ICAM1
48kaposi's sarcoma10.0IFNA1
49cervical cancer10.0NCL, STAT1
50chronic inflammatory demyelinating polyradiculoneuropathy10.0IFNB1

Graphical network of the top 20 diseases related to Parainfluenza Virus Type 3:



Diseases related to parainfluenza virus type 3

Clinical Features for Parainfluenza Virus Type 3

Drugs & Therapeutics for Parainfluenza Virus Type 3

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Parainfluenza Virus Type 3

Drug clinical trials:

Search ClinicalTrials for Parainfluenza Virus Type 3

Search NIH Clinical Center for Parainfluenza Virus Type 3

Search CenterWatch for Parainfluenza Virus Type 3

Genetic Tests for Parainfluenza Virus Type 3

Anatomical Context for Parainfluenza Virus Type 3

Animal Models for Parainfluenza Virus Type 3 or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Parainfluenza Virus Type 3

Genetic Variations for Parainfluenza Virus Type 3

Expression for genes affiliated with Parainfluenza Virus Type 3

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Parainfluenza Virus Type 3

Search GEO for disease gene expression data for Parainfluenza Virus Type 3.

Pathways for genes affiliated with Parainfluenza Virus Type 3

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 54Reactome, 52QIAGEN
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Pathways related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6STAT1, ICAM1, IL2
2
Immune response IFN gamma signaling pathway
Hide members
9.6EIF2AK2, STAT1, ICAM1
3
Translation Insulin regulation of translation
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9.2EIF2AK2, NCL, PRKCZ
49.1STAT1, IFNB1, ICAM1, EIF2AK2
5
Hide members
9.0IFNA1, IFNB1, IFIH1
68.9IFNA1, DDX58, IFNB1
78.9IFNB1, STAT1, IFNA1
88.9IL2, IFNB1, IFNA1
9
Hide members
8.7IFIH1, IFNA1, DDX58, IFNB1
108.6IL2, STAT1, IFNB1, IFNA1
11
Hide members
8.6IL2, ICAM1, IFNB1, IFNA1
12
Immune response IFN alpha/beta signaling pathway
Hide members
8.5MX1, RNASEL, STAT1, IFNB1, IFNA1
138.4IL2, PRKCZ, IFNA1, IFNB1
14
Hide members
8.1DDX58, STAT1, IFNB1, IFNA1, IFIH1, IL2
15
Hide members
8.1IL2, IFNA1, IFNB1, STAT1, PRKCZ
168.1IFNA1, IFNB1, DDX58, RNASEL, EIF2AK2, STAT1
17
Hide members
7.3EIF2AK2, IFNA1, IFNB1, ICAM1, DDX58, RNASEL
18
Hide members
6.8STAT1, MX1, EIF2AK2, IL2, RNASEL, DDX58
19
Hide members
6.5MX1, EIF2AK2, DDX58, RNASEL, IL2, IFIH1

Compounds for genes affiliated with Parainfluenza Virus Type 3

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1indoleamine4510.4STAT1
2estrogen4510.3FURIN
3pge24510.0CRAT, IL2
4poly c459.7IFNB1, RNPC3, EIF2AK2
5ampligen459.5IFNA1, RNASEL
6levamisole45 1110.4IL2, IFNA1, NEU1
7rebif459.4MX1, IFNB1, IFNA1
8avonex459.4MX1, IFNB1, IFNA1
9betaseron459.4MX1, IFNA1, IFNB1
10ribavirin45 50 1111.3MX1, STAT1, EIF2AK2, IL2, RNASEL, NEU1
11rrna459.3RNPC3, RNASEL, NCL, GAPDH
12glatiramer acetate45 1110.3IL2, IFNB1, IFNA1
13tetracycline45 1110.2FURIN, IFNB1, EIF2AK2, CRAT
14neomycin459.2IL2, RNPC3, CRAT, IFNB1
15acyclovir45 1110.2IFNA1, IFNB1, NEU1
16dacarbazine45 1110.1IFNB1, IL2, IFNA1
17cycloheximide459.1IFNA1, IFNB1, STAT1, MX1
18imiquimod45 29 60 1112.1IFNA1, MX1, STAT1, IFNB1
19temozolomide45 1110.1IFNA1, IFNB1, IL2
20biotin45 11 2411.1IL2, RNPC3, STAT1, GAPDH
21aspartate459.0CRAT, EIF2AK2, GAPDH, FURIN
22zidovudine45 1110.0IFNB1, NEU1, IFNA1, IL2
23inosine monophosphate459.0EIF2AK2, STAT1, IFNA1, IFNB1
24chloroquine45 2 50 29 1112.8EIF2AK2, IFNA1, IFNB1, IL2
25polyethylene glycol458.8IFNA1, GAPDH, NEU1, ICAM1
26neopterin458.8ICAM1, IL2, IFNB1, IFNA1, MX1
27tamoxifen45 50 29 1111.6CRAT, IL2, IFNA1, IFNB1
28poly(i-c)458.5IFNA1, STAT1, IFNB1, DDX58, EIF2AK2, MX1
29arginine458.5RNPC3, EIF2AK2, STAT1, FURIN, CRAT, RNASEL
30heparin45 29 11 2411.5IFNB1, GAPDH, NEU1, EIF2AK2, NCL, FURIN
31rantes458.4STAT1, EIF2AK2, IL2, IFNB1, IFNA1, ICAM1
32adenine45 11 2410.4IFNB1, RNPC3, RNASEL, GAPDH, EIF2AK2, CRAT
33serine458.3MX1, EIF2AK2, NCL, PRKCZ, STAT1, NEU1
34ly294002458.3STAT1, GAPDH, ICAM1, IFNB1, PRKCZ
35ifn-alpha458.2RNASEL, IL2, EIF2AK2, MX1, IFNB1, STAT1
36vegf458.2IFNB1, IFNA1, GAPDH, STAT1, PRKCZ
37retinoid458.1IFNA1, IFNB1, GAPDH, STAT1, CRAT
38adenylate458.1NCL, IFNB1, GAPDH, CRAT, RNPC3, RNASEL
39h2o2458.0NEU1, STAT1, CRAT, GAPDH, ICAM1, IFNB1
40nitric oxide45 11 2410.0ICAM1, PRKCZ, GAPDH, CRAT, EIF2AK2, RNASEL
41atp45 298.9MX1, NCL, RNPC3, RNASEL, EIF2AK2, STAT1
42cisplatin45 50 60 1110.8GAPDH, IFNA1, IL2, STAT1, CRAT, IFNB1
43cyclosporin a45 29 609.7IL2, RNPC3, IFNA1, ICAM1, GAPDH, STAT1
442,5-oligoadenylate457.7IFNA1, MX1, EIF2AK2, IL2, RNASEL, STAT1
45polyinosinic-polycytidylic acid457.7IFNA1, EIF2AK2, IFNB1, STAT1, DDX58, IL2
46oligonucleotide457.7RNASEL, EIF2AK2, IFNB1, GAPDH, CRAT, RNPC3
47rapamycin457.6STAT1, IL2, PRKCZ, IFNA1, GAPDH
48tyrosine457.3STAT1, RNPC3, IL2, EIF2AK2, IFNB1, IFNA1
49actinomycin d457.2CRAT, GAPDH, STAT1, IL2, IFNA1, IFNB1
50retinoic acid45 246.9EIF2AK2, IFIH1, NCL, PRKCZ, NEU1, DDX58

GO Terms for genes affiliated with Parainfluenza Virus Type 3

Sources:
16Gene Ontology
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Cellular components related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058297.7MX1, EIF2AK2, RNASEL, PRKCZ, DDX58, STAT1

Biological processes related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cytoplasmic pattern recognition receptor signaling pathway in response to virusGO:03952810.2DDX58, IFIH1
2regulation of type III interferon productionGO:03434410.2IFIH1, DDX58
3detection of virusGO:00959710.1DDX58, IFIH1
4positive regulation of interferon-alpha productionGO:03272710.1DDX58, IFIH1
5response to exogenous dsRNAGO:0433309.7DDX58, STAT1
6natural killer cell activationGO:0301019.6IL2, IFNB1
7type I interferon-mediated signaling pathwayGO:0603379.5MX1, RNASEL, IFNB1, STAT1
8negative regulation of viral genome replicationGO:0450719.5MX1, IFNB1, RNASEL, EIF2AK2
9positive regulation of NF-kappaB transcription factor activityGO:0510929.3PRKCZ, ICAM1, EIF2AK2
10cytokine-mediated signaling pathwayGO:0192219.2MX1, RNASEL, ICAM1, STAT1, IFNB1
11modulation by virus of host morphology or physiologyGO:0190489.2DDX58, EIF2AK2, STAT1, ICAM1, IFIH1
12response to virusGO:0096159.2IFIH1, IFNB1, DDX58, EIF2AK2, MX1
13defense response to virusGO:0516079.2RNASEL, MX1, EIF2AK2, STAT1, IFNB1
14innate immune responseGO:0450879.0IFNB1, EIF2AK2, DDX58, MX1, IFIH1
15positive regulation of transcription from RNA polymerase II promoterGO:0459449.0STAT1, DDX58, RNASEL, IL2, IFNB1

Molecular functions related to Parainfluenza Virus Type 3 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-stranded RNA bindingGO:0037259.6EIF2AK2, DDX58, IFIH1

Products for genes affiliated with Parainfluenza Virus Type 3

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Parainfluenza Virus Type 3

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet