Paralysis malady

MedlinePlus: Paralysis is the loss of muscle function in part of your body. it happens when something goes wrong with the way messages pass between your brain and muscles. paralysis can be complete or partial. it can occur on one or both sides of your body. it can also occur in just one area, or it can be widespread. paralysis of the lower half of your body, including both legs, is called paraplegia. paralysis of the arms and legs is quadriplegia. most paralysis is due to strokes or injuries such as spinal cord injury or a broken neck. other causes of paralysis include nerve diseases such as amyotrophic lateral sclerosis autoimmune diseases such as guillain-barre syndrome bell's palsy, which affects muscles in the face polio used to be a cause of paralysis, but polio no longer occurs in the u.s.²³

MalaCards: Paralysis is related to hypokalemic periodic paralysis and hyperkalemic periodic paralysis. An important gene associated with Paralysis is CACNA1S (calcium channel, voltage-dependent, L type, alpha 1S subunit), and among its related pathways are Cardiac muscle contraction and Aldosterone-regulated sodium reabsorption. The compounds lactate and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and skeletal muscle, and related mouse phenotypes are normal and embryogenesis.

Wikipedia: Paralysis is loss of muscle function for one or more muscles. Paralysis can be accompanied by a loss of...⁴⁴ more...

paralysis 17 32 23

Diseases related to paralysis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 596)

id	Related Disease	Score	Top Affiliating Genes
1	hypokalemic periodic paralysis	36.6	KCNE3, KCNJ2, KCNJ18, SCN7A, SCN4A, CHKB
2	hyperkalemic periodic paralysis	35.1	KCNE3, KCNJ2, SCN4A, CACNA1S
3	thyrotoxic periodic paralysis	33.0	KCNJ18, SCN4A, ATP1A2, ATP1B4, ATP1A1, ATP1B1
4	spastic paralysis	32.6	ARHGEF2, ALS2, TARDBP
5	familial periodic paralysis	32.3	KCNJ2, SCN7A, SCN4A
6	hypokalemic periodic paralysis type 2	30.5	SCN7A, SCN4A, QDPR
7	peroneal nerve paralysis	30.1	IPP, SS18, SSX2B, CPN1
8	periodic paralyses	30.0	KCNE3, KCNJ2, SCN4A, CACNA1S
9	myotonia	30.0	SCN7A, SCN4A, CHKB, HSPG2
10	facial paralysis	30.0	LRP5, CD82, FKBP4, GSN, GSX1, ANKH
11	spasticity	29.8	T, CD274, ARHGEF2, ARHGEF1, INS, IL10
12	malignant hyperthermia	29.0	PIK3C2A, SCN7A, SCN4A, CHKB, QDPR, INS
13	poliomyelitis	28.4	CHAT, ARHGEF1, IL10, RPS27A, SYP
14	parkinson's disease	27.9	VCP, BCHE, KCNJ5, CHAT, CHKB, ATXN2
15	hypokalemia	27.7	PIK3C2A, KCNE3, KCNJ18, KCNJ5, SCN4A, ATP1A2
16	rabies	27.7	T, CD274, IL10, IL12B, IL1B, ALAD
17	muscle disorders	27.3	CHKA, CHKB, RYR1, GAA
18	narcolepsy	27.0	CHKB, MOG, CD274, INS, CADM1, DRD2
19	central pontine myelinolysis	26.9	PDE4A, QDPR, MOG, ARHGEF2, TRB@, GDAP1
20	progressive supranuclear palsy	26.4	CHAT, DRD2, RPS27A, ACHE, HCRT
21	neurologic diseases	26.4	QDPR, ATP1A2, MOG, IL1B, PLCB4, ACHE
22	spinal cord injury	25.9	PIK3C2A, PDE4A, INS, IL10, IL1B, F2
23	prion disease	25.8	CHAT, HSPB1, CA2, RPS27A, ACHE, GDNF
24	supranuclear palsy	25.6	BCHE, CHAT, DRD2, RPS27A, ACHE, HCRT
25	graves' disease	25.3	KCNJ18, CHKB, CD274, INS, IL10, IL12B
26	hepatitis c	25.1	IL10, IL12B, IFNA2, F2, TSHR, TGFB1
27	neurodegeneration	25.0	NAIP, VCP, BCHE, CHKA, CHAT, ATXN2
28	polyneuropathy	24.8	INS, GSN, IL10, IL1B, IFNA2, HSPG2
29	motor neuron disease	24.6	SETX, NAIP, VCP, VAPB, CHAT, ARHGEF2
30	arthropathy	24.0	MIF, IL10, IL1B, ANKH, F2, HSPG2
31	sjogren's syndrome	23.9	PIK3C2A, ATP1A2, CD274, IL10, IL1B, HSPG2
32	sepsis	23.8	PDE4A, MIF, GSN, IL10, IL12B, IL1B
33	seizures	23.2	PIK3C2A, SCN7A, CHAT, CHKB, ATP1A2, MIF
34	thrombosis	22.8	PIK3C2A, CHKB, FIG4, INS, IL10, IL1B
35	adenoma	22.6	KLF4, PDE4A, KCNJ5, SCN4A, CHKA, CD82
36	myopathy	22.5	PIK3C2A, VCP, SCN4A, CHKA, CHAT, CHKB
37	cerebritis	21.9	PIK3C2A, KLF4, NDE1, NDEL1, PDE4A, BCHE
38	neuropathy	21.4	PIK3C2A, PDE4A, SETX, NAIP, VCP, BCHE
39	diabetes mellitus	20.4	PIK3C2A, LRP5, PDE4A, BCHE, KCNJ5, CHAT
40	thyroiditis	20.1	PIK3C2A, KLF1, KLF4, PDE4A, VCP, SCN4A
41	hypertension	19.2	PIK3C2A, LRP5, PDE4A, KCNJ5, SCN7A, ATP1A2
42	hepatitis	17.8	PIK3C2A, KLF2, NAIP, VCP, VAPB, USP14
43	neuronitis	15.7	PIK3C2A, KLF4, NDE1, NDEL1, PDE4A, SEMA3D
44	ventricular fibrillation	14.1	KCNE3, KCNJ2, KCNJ5, CHKB, MB, CACNA1C
45	lateral sclerosis	14.0	ARHGEF2, ALS2, SOD1
46	neuromuscular disease	14.0	NAIP, SCN4A, CHKB, MB, TCAP, DCTN1
47	hyperphenylalaninemia	13.9	QDPR, SOD1, NEFH, CACNA1C
48	arrhythmogenic right ventricular dysplasia/cardiomyopathy multi-gene panels	13.9	PIK3C2A, KCNE3, KCNJ2, KCNJ5, SCN4A, CHKA
49	compartment syndrome	13.9	CHKA, CHKB, MB
50	motor neuronopathy	13.9	IGHMBP2, HSPB1, HMN7A, DCTN1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to paralysis:

²²

MGI Mouse Phenotypes related to paralysis:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal phenotype	MP:0002873	INF	LRP5, , TP63, IL10, TRB@, TPI1
2	embryogenesis phenotype	MP:0005380	INF	SS18, LRP5, TP63, HOXB1, , MB
3	muscle phenotype	MP:0005369	INF	, CHKB, ATP1A2, ATP1A1, ATP1B1,
4	integument phenotype	MP:0010771	INF	LMO7, KLF1, DRD2, SP6, SNAP25, TDO2
5	reproductive system phenotype	MP:0005389	INF	GJA5, CADM1, IL10, GSX1, FKBP4,
6	nervous system phenotype	MP:0003631	INF	, ATP1B2, , ATP1A2, , CHKB
7	skeleton phenotype	MP:0005390	INF	HOXB1, DRD2, TP63, INS, , IAPP
8	craniofacial phenotype	MP:0005382	INF	, HOXB1, SP6, NF2, ACHE,
9	respiratory system phenotype	MP:0005388	INF	TRIM63, DRD2, TP63, TRPV4, ANKH, GJA5
10	cellular phenotype	MP:0005384	INF	TSHR, SEMA3F, NDEL1, NDE1, KLF4, KLF2
11	behavior/neurological phenotype	MP:0005386	INF	, , ADRB2, GABRA3, GAA, GDNF
12	growth/size phenotype	MP:0005378	INF	INS, , FKBP4, , , NF2
13	endocrine/exocrine gland phenotype	MP:0005379	INF	HOXB1, , GSX1, GSN, ,
14	immune system phenotype	MP:0005387	INF	, CADM1, ALS2, F2, IAPP, ANKH
15	homeostasis/metabolism phenotype	MP:0005376	INF	INS, TRIM63, TP63, TPI1, TPO, DRD2
16	mortality/aging	MP:0010768	INF	SEMA3A, , CD274, FKBP4, , GSN
17	digestive/alimentary phenotype	MP:0005381	INF	DRD3, KCNE3, DRD2, TGFB1, RYR1, HSPG2
18	cardiovascular system phenotype	MP:0005385	INF	PDE4A, KLF2, ATP1A2, , KCNJ5, KCNJ2
19	hematopoietic system phenotype	MP:0005397	INF	KLF1, , IL12B, HOXB1, GSX1, GSN
20	vision/eye phenotype	MP:0005391	INF	DRD4, TP63, HSPG2, IL10, INS,

Articles related to paralysis:

(show top 50)    (show all 172)

id	Title	Authors	Year	Affiliating Genes
1	Severe phenotypes of paralysis periodica paramyotonia are associated with the Met1592Val mutation in the voltage-gated sodium channe l gene (SCN4A) in a Chinese family. (21665479)	Feng Y.... Zhang C.	2011	SCN4A
2	Identification and functional characterization of Kir 2.6 mutations associated with non-familial hypokalemic periodic paralysis. (21665951)	Cheng C.J.... Huang C.L.	2011	KCNJ18
3	Multi-minicore disease and atypical periodic paralysi s associated with novel mutations in the skeletal muscle ryanodine receptor (RY R1) gene. (20080402)	Zhou H.... Jungbluth H.	2010	CACNA1S
4	Andersen cardiodysrhythmic periodic paralysis with KC NJ2 mutations: a novel mutation in the pore selectivity filter residue. (20382953)	Lim B.C.... Chae J.H.	2010	KCNJ2
5	Voltage sensor charge loss accounts for most cases of hypokalemic periodic paralysis. (19118277)	Matthews E.... Hanna M.G.	2009	CACNA1S
6	Tubular aggregates in paralysis periodica paramyotonica with T704M mutation of SCN4A. (19077043)	Luan X.... Yuan Y.	2009	SCN4A
7	Progressive muscle atrophy with hypokalemic periodic paralysis and calcium channel mutation. (17587224)	Meyer T.... Spuler S.	2008	CACNA1S
8	Mutations of sodium channel alpha-subunit genes in Chinese patients with normokalemic periodic paralysis. (18046642)	Xiuhai G.... Yanling M.	2008	SCN4A, SCN7A
9	Continuous infusion of sivelestat sodium hydrate prevents lipopolysaccharide-induced intestinal paralysis and hypotension in conscious guinea-pigs. (18346172)	Hara S.... Yamamoto Y.	2008	ELANE
10	Rhabdomyolysis in a patient with West Nile encephalit is and flaccid paralysis. (18488686)	Gupta M.... Freire A.X.	2008	CHKA
11	Genotype-phenotype correlation and therapeutic rationale in hyperkalemic periodic paralysis. (17395131)	Jurkat-Rott K.... Lehmann-Horn F.	2007	SCN4A
12	Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. (16449802)	Abbott G.W.... Goldstein S.A.	2006	KCNE3, KCNC4
13	Mutation screening in Chinese hypokalemic periodic paralysis patients. (16386935)	Wang W.... Ning G.	2006	SCN4A
14	Gene analysis of the calcium channel 1 subunit and clinical studies for two patients with hypokalemic periodic paralysis. (17185904)	Kageyama K.... Suda T.	2006	CACNA1S
15	wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death. (17008404)	Gnerer J.P.... Ganetzky B.	2006	TPI1
16	Hypokalemic paralysis due to Gitelman syndrome: a family study. (17000984)	Ng H.Y.... Lee C.T.	2006	SLC12A3
17	Familial periodic paralysis and Charcot-Marie-Tooth disease in a 7-generation family. (15642860)	Hisama F.M.	2005	SCN4A
18	Hypokalemic thyrotoxic periodic paralysis (HTPP). Rare differential diagnosis in case of acute tetraparesis in Europe (16170648)	Gaul C.... Zierz S.	2005	TPO
19	Envenoming bites by kraits: the biological basis of treatment-resistant neuromuscular paralysis. (16195243)	Prasarnpun S.... Harris J.B.	2005	SNAP25
20	Thyrotoxic periodic paralysis associated with a mutation in the sodium channel gene SCN4A. (15645704)	Lane A.H.... Braziunene I.	2004	SCN4A
21	No mutation in the KCNE3 potassium channel gene in Chinese thyrotoxic hypokalaemic periodic paralysis patients. (15212652)	Tang N.L.... Cockram C.S.	2004	KCNE3
22	A family of hypokalemic periodic paralysis with CACNA1S gene mutation showing incomplete penetrance in women. (15098604)	Kawamura S.... Seki K.	2004	CACNA1S
23	Association of novel single nucleotide polymorphisms in the calcium channel alpha 1 subunit gene (Ca(v)1.1) and thyrotoxic periodic paralysis. (15001631)	Kung A.W.... Chan V.	2004	CACNA1S
24	Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene. (12145748)	Eymard-Pierre E.... Boespflug-Tanguy O.	2002	ALS2
25	A mutation in the KCNE3 potassium channel gene is associated with susceptibility to thyrotoxic hypokalemic periodic paralysis. (12414843)	Dias da Silva M.R.... Maciel R.M.B.	2002	SCN4A, KCNE3
26	A case of familial hypokalemic periodic paralysis with hyperuricemia during paralytic attack and genetic analysis of the pedigree (11808349)	Katsuno M.... Sobue G.	2001	CACNA1S
27	Familial hypokalemic periodic paralysis (15775665)	Ikeda Y.... Okamoto K.	2001	CACNA1S
28	Sodium channel gene mutations in hypokalemic periodic paralysis: an uncommon cause in the UK. (11591859)	Davies N.P.... Hanna M.G.	2001	CACNA1S
29	Prolonged paralysis associated with succinylcholine--a case report. (11392072)	Kuo C.H.... Tseng C.K.	2000	BCHE
30	Activation and inactivation of the voltage-gated sodium channel: role of segment S5 revealed by a novel hyperkalaemic periodic paralysis mutation. (10366610)	Bendahhou S.... Ptacek L.J.	1999	SCN4A, SCN7A
31	Linkage of malignant hyperthermia and hyperkalemic periodic paralysis to the adult skeletal muscle sodium channel (SCN4A) gene in a large pedigree. (9508059)	Moslehi R.... Friedman J.M.	1998	SCN4A
32	Periodic hypokalemic paralysis disclosing thyrotoxic osis (9793040)	Penisson-Besnier I.... Rohmer V.	1998	ATP1A2
33	Immune stimulation with G-CSF (Neupogen) in septic patients with immune paralysis (9931795)	Agnes A.... MA1ller J.M.	1998	CSF3
34	Identification of mutations in the CACNL1A3 gene in 13 families of Scandinavian origin having hypokalemic periodic paralysis and evidence of a founder effect in Danish families. (9066893)	Sillen A.... Wadelius C.	1997	CACNA1S
35	Mutation analysis of the CACNL1A3 gene in Japanese hypokalemic periodic paralysis families (9436445)	Ikeda Y.... Shoji M.	1997	CACNA1C
36	Markedly prolonged paralysis after mivacurium in a patient apparently heterozygous for the atypical and usual pseudocholinesterase alleles by conventional biochemical testing. (9024049)	Rosenberg M.K.... Lebenbom-Mansour M.	1997	BCHE
37	Familial hyperkalemic periodic paralysis: a brief review of the adult human skeletal muscle sodium channel and the application of LA-PCR to the SCN4A gene analysis (9436446)	Sakoda S.... Osame M.	1997	SCN4A
38	Genotype-phenotype correlations of DHP receptor alpha 1-subunit gene mutations causing hypokalemic periodic paralysis. (9132138)	Fouad G.... Ptacek L.J.	1997	CACNA1S
39	Hyperkalemic periodic paralysis caused by recurring mutation in the adult muscle sodium channel alpha-subunit gene. (8985730)	Sillen A.... Gustavson K.H.	1996	SCN4A
40	Differential diagnosis of periodic paralysis aided by in vitro myography. (7767090)	Iaizzo P.A.... Lehmann-Horn F.	1995	SCN4A
41	Hyperkalemic periodic paralysis with cardiac dysrhythmia: a novel sodium channel mutation? (7695243)	Baquero J.L.... Ebeid M.R.	1995	SCN4A
42	Mutation in DHP receptor alpha 1 subunit (CACLN1A3) gene in a Dutch family with hypokalaemic periodic paralysis. (7897626)	Boerman R.H.... Isles D.E.	1995	CACNA1S
43	A calcium channel mutation causing hypokalemic periodic paralysis. (7987325)	Jurkatt-Rott K.... Fontaine B.	1994	CACNA1S
44	Mutations in the muscle sodium channel gene (SCN4A) in 13 French families with hyperkalemic periodic paralysis and paramyotonia congenita: phenotype to genotype correlations and demonstration of the predominance of two mutations. (8044656)	Plassart E.... Desnuelle C.	1994	SCN4A
45	Theoretical reconstruction of myotonia and paralysis caused by incomplete inactivation of sodium channels. (8396455)	Cannon S.C.... Corey D.P.	1993	SCN7A
46	Functional expression of sodium channel mutations identified in families with periodic paralysis. (8382500)	Cannon S.C.... Strittmatter S.M.	1993	SCN7A
47	Paramyotonia congenita and hyperkalemic periodic paralysis map to the same sodium-channel gene locus. (1654742)	Ptacek L.J.... Leppert M.	1991	SCN4A
48	Increase in serum myoglobin, creatine kinase, and free fatty acids, during recovery from a paralytic attack in hypokalemic periodic paralysis. (1660381)	De Keyser J.... Ebinger G.	1991	CHKB
49	A Met-to-Val mutation in the skeletal muscle Na+ channel alpha- subunit in hyperkalaemic periodic paralysis. (1659668)	Rojas C.V.... Brown R.H. Jr.	1991	SCN4A
50	Early diaphragmatic paralysis. In infants with genetic disorders. (2407409)	Sivan Y.... Galvis A.	1990	GAA

Genes related to paralysis according to GeneCards:

(show top 50)    (show all 113)

id	Symbol	Description	Score	GeneCards Section Context
1	CACNA1S	calcium channel, voltage-dependent, L type, alpha 1S subunit	11.1	Publications, Summaries, Aliases & Descriptions
2	SCN4A	sodium channel, voltage-gated, type IV, alpha subunit	11.1	Publications, Summaries
3	KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2	11.1	Publications, Summaries
4	ALS2	amyotrophic lateral sclerosis 2 (juvenile)	11.1	Publications, Summaries
5	KCNE3	potassium voltage-gated channel, Isk-related family, member 3	11.1	Publications, Summaries
6	KCNJ18	potassium inwardly-rectifying channel, subfamily J, member 18	11.1	Aliases & Descriptions, Publications
7	LAP	Laryngeal adductor paralysis	11.0	Aliases & Descriptions
8	SCN7A	sodium channel, voltage-gated, type VII, alpha subunit	11.0	Publications
9	USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	11.0	Summaries
10	QDPR	quinoid dihydropteridine reductase	11.0	Publications
11	SLC12A3	solute carrier family 12 (sodium/chloride transporters), member 3	11.0	Publications
12	HMN7A	Motor neuronopathy, distal hereditary, type VIIA	11.0
13	ATP1A2	ATPase, Na+/K+ transporting, alpha 2 polypeptide	11.0	Publications
14	ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	11.0
15	RYR1	ryanodine receptor 1 (skeletal)	11.0	Publications
16	CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	11.0	Publications
17	SOD1	superoxide dismutase 1, soluble	11.0	Publications
18	RNF112	ring finger protein 112	11.0
19	ATP1B2	ATPase, Na+/K+ transporting, beta 2 polypeptide	11.0	Publications
20	ATP1B4	ATPase, Na+/K+ transporting, beta 4 polypeptide	11.0	Publications
21	PODXL2	podocalyxin-like 2	11.0
22	ATP1B1	ATPase, Na+/K+ transporting, beta 1 polypeptide	11.0	Publications
23	CCDC37	coiled-coil domain containing 37	11.0
24	ATP1A1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	11.0	Publications
25	GDAP1	ganglioside induced differentiation associated protein 1	11.0	Publications
26	CPN1	carboxypeptidase N, polypeptide 1	11.0
27	DNAJC5	DnaJ (Hsp40) homolog, subfamily C, member 5	11.0	Publications
28	TARDBP	TAR DNA binding protein	11.0	Publications
29	KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	11.0	Publications
30	ANKH	ankylosis, progressive homolog (mouse)	11.0
31	SNAP25	synaptosomal-associated protein, 25kDa	11.0	Publications
32	BCHE	butyrylcholinesterase	11.0	Publications
33	GSN	gelsolin	11.0
34	PRF1	perforin 1 (pore forming protein)	11.0
35	CHKB	choline kinase beta	11.0	Publications
36	ADRB2	adrenoceptor beta 2, surface	11.0	Publications
37	TSHR	thyroid stimulating hormone receptor	11.0	Publications
38	TPO	thyroid peroxidase	11.0	Publications
39	ST18	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	11.0
40	GDNF	glial cell derived neurotrophic factor	11.0	Publications
41	ACHE	acetylcholinesterase	11.0	Publications
42	MB	myoglobin	11.0	Publications
43	HSPB1	heat shock 27kDa protein 1	11.0	Publications
44	HSPA4	heat shock 70kDa protein 4	11.0	Publications
45	TP63	tumor protein p63	11.0
46	TGFB1	transforming growth factor, beta 1	11.0
47	INS	insulin	11.0	Publications
48	GSX1	GS homeobox 1	10.9
49	SP6	Sp6 transcription factor	10.9	Disorders
50	ANKRD2	ankyrin repeat domain 2 (stretch responsive muscle)	10.9	Publications

Pathways related to paralysis according to GeneDecks:

(show all 16)

id	Pathway	Score	Top Affiliating Genes
1	Cardiac muscle contraction20	10.7	ATP1A2, ATP1A1, CACNA1C, CACNA1S, ATP1B2, ATP1B4
2	Aldosterone-regulated sodium reabsorption20	10.7	ATP1A2, INS, ATP1B1, ATP1A1, ATP1B4
3	Proximal tubule bicarbonate reclamation20	10.6	ATP1A2, CA2, ATP1B2, ATP1B1, ATP1A1, ATP1B4
4	Antiarrhythmic Pathway, Pharmacodynamics34	10.6	CACNA1C, GJA5, ATP1A1, KCNJ5, KCNE3, ADRB2
5	Carbohydrate digestion and absorption20	10.5	ATP1A2, ATP1B4, ATP1A1, ATP1B1, ATP1B2
6	Bile secretion20	10.4	ATP1A2, ATP1B4, ATP1A1, ATP1B1, ATP1B2, CA2
7	Aldosterone Signaling in Epithelial Cells36	10.4	ATP1A1, ATP1A2, SLC12A3, PLCB4, ATP1B2, ATP1B4
8	Protein digestion and absorption20	10.4	ATP1B4, ATP1B2, ATP1B1, ATP1A1, KCNE3, ATP1A2
9	Endocrine and other factor-regulated calcium reabsorption20	10.3	ATP1A2, ATP1A1, ATP1B1, ATP1B2, PLCB4, ATP1B4
10	Gastric acid secretion20	10.3	ATP1B4, KCNJ2, PLCB4, CA2, ATP1B2, ATP1B1
11	Salivary secretion20	10.2	ADRB2, PLCB4, ATP1B2, ATP1B1, ATP1B4, ATP1A2
12	Mineral absorption20	10.1	ATP1B1, ATP1A1, ATP1A2, ATP1B4, ATP1B2
13	Pancreatic secretion20	10.1	ATP1A1, ATP1A2, ATP1B4, ATP1B1, ATP1B2, CA2
14	Dopamine-DARPP32 Feedback onto cAMP Pathway36	9.8	DRD4, CACNA1C, CACNA1S, PLCB4, DRD3, DRD2
15	Autoimmune thyroid disease20	9.4	TSHR, TPO, IFNA2, IL10, PRF1
16	Cytokine Network36	8.8	IL12B, IL10, IL16, IFNA2, IL1B

Compounds related to paralysis according to GeneDecks:

(show top 50)    (show all 167)

id	Compound	Score	Top Affiliating Genes
1	lactate32	INF	MIF, CHKB, , CHKA, KCNJ5, BCHE
2	tyrosine32	INF	GDNF, ADRB2, TRIM63, TRPV4, CA2, HSPB1
3	calcium32 9 18 9	INF	PIK3C2A, LRP5, PDE4A, , , MYPN
4	norepinephrine32 9 18 9	INF	GDNF, ADRB2, RYR1, SLC17A5, SYP,
5	malondialdehyde32	INF	CHKB, CHKA, PIK3C2A, , , HSPB1
6	nitric oxide32 9 18 9	INF	TPO, SNAP25, , SYP, ADRB2, GDNF
7	catecholamine32	INF	IAPP, DRD3, DRD4, SNAP25, , SYP
8	glutamate32	INF	HSPA4, TP63, TPI1, DRD2, DRD4, SNAP25
9	testosterone32 9 18 9	INF	GSN, MB, IAPP, , TPO, RPS27A
10	acetylcholine32 9 18 9	INF	PIK3C2A, RPS27A, SNAP25, DRD2, TPO, HSPA4
11	sodium32 18	INF	KCNJ5, PIK3C2A, TSHR, , DRD4, DRD3
12	retinoic acid32 42 18	INF	IFNA2, IL1B, TGFB1, MIF, , CHKA
13	paraffin32	INF	TGFB1, NF2, SYP, , TSHR, CHKA
14	atp32	INF	PIK3C2A, PDE4A, , LIG1, KCNJ5, CHKA
15	lipid32	INF	PIK3C2A, PDE4A, IL16, IFNA2, IAPP,
16	nicotine32 34 9 9	13.5	SLC17A5
17	succinylcholine32 9 9	12.3	SLC17A5, PIK3C2A, BCHE, SCN4A, CHKB, MB
18	digoxin32 42 34 9 18 9	14.4	RYR1, ATP1A2, ATP1B4, ATP1B1, ATP1B2, IL10
19	hydrogen32 18	10.2	HSPB1, PDE4A, CHKB, QDPR, MIF, MB
20	h2o232	8.9	TDO2, IAPP, RPS27A, ELANE, HSPG2, GDNF
21	doxorubicin32 34 9 9	11.1	PIK3C2A, CHKA, MIF, TP63, RPS27A, TGFB1
22	vegf32	6.4	HSPG2, IFNA2, MB, IL1B, IL16, IL10
23	glutamine32	INF	, RYR1, PDE4A, SYP, CHKB,
24	fatty acid32	INF	SLC25A4, , GAA, PLCB4, GSN, TPI1
25	glucose32	INF	PDE4A, KCNJ5, MIF, GSN, HSPA14, HSPB1
26	potassium32 9 18 9	INF	ADRB2, RYR1, SLC17A5, SLC12A3, SYP, CHKB
27	superoxide32 18	INF	PRF1, SYP, TARDBP, ELANE, TPI1, CA2
28	adenylate32	INF	HSPA4, HSPG2, IAPP, MB, GSN, CHKB
29	oxygen32 18	INF	CHKB, MIF, PIK3C2A, PLCB4, LIG1, CA2
30	lead32	INF	CA2, HSPB1, DRD3, , DRD4, QDPR
31	lysine32	INF	TDO2, TSHR, SYT2, TP63, TPO, ARHGEF2
32	sodium nitroprusside32	INF	ELANE, HSPA4, MB, IL12B, , KCNJ5
33	arginine32	INF	SOD1, HSPB1, CA2, TP63, TPO, PLCB4
34	ascorbic acid32 18	INF	IFNA2, HSPA4, TPO, DRD2, HSPB1, HSPG2
35	aspartate32	INF	CHKB, MB, F2, CA2, TPO, SNAP25
36	cocaine32 9 9	INF	, BCHE, MB, GDNF, ADRB2,
37	histidine32	INF	MB, CA2, HSPB1, , TP63, TPO
38	heroin32 9 9	INF	, DRD2, PIK3C2A, IL10, BCHE, DRD3
39	cysteine32	INF	DNAJC5, TPI1, TPO, SNAP25, RPS27A, NF2
40	dexamethasone32 42 34 9 9	INF	HSPG2, IAPP, IL1B, IL16, IL10, INS
41	creatinine32	INF	, HSPB1, HSPA4, CA2, TPI1, TPO
42	dopamine32 9 18 9	INF	DRD4, SNAP25, ACHE, , SYP, ADRB2
43	thymidine32 18	INF	CSF3, IFNA2, TSHR, IL1B, IL16, IL10
44	haloperidol32 34 9 9	INF	, PIK3C2A, SYP, MB, DRD3,
45	serine32	INF	GSN, IL10RA, IL16, MB, IAPP, F2
46	epinephrine32 9 18 9	INF	ELANE, PDE4A, CHKB, INS, MB, IAPP
47	phospholipid32	INF	PRF1, PDE4A, GSN, CHKB, IAPP, F2
48	alanine32	INF	SLC12A3, CHKB, QDPR, MIF, ARHGEF2, INS
49	risperidone32 34 9 18 9	INF	, DRD4, DRD3, SLC17A5, DRD2, IL10
50	thyroxine32 18	INF	TPO, INS, SLC17A5, PIK3C2A, HSPA4, IFNA2

Cellular components related to paralysis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	INF	PLCB4, , QDPR, ALS2, PIK3C2A, TDO2
2	cytoplasm	GO:005737	INF	SOD1, PIK3C2A, LMO7, USP14, ,
3	I band	GO:031674	10.5	MYPN, ANKRD1, ANKRD2, RYR1, CACNA1S
4	T-tubule	GO:030315	10.5	CACNA1C, KCNJ5, CACNA1S, RYR1
5	sodium:potassium-exchanging ATPase complex	GO:005890	10.2	ATP1A2, ATP1B1, ATP1A1
6	extracellular space	GO:005615	6.6	SEMA3F, TGFB1, CPN1, CSF3, SOD1, CA2
7	neuronal cell body	GO:043025	INF	TGFB1, SNAP25, CACNA1C, DRD4, ALS2, IAPP
8	integral to plasma membrane	GO:005887	INF	KCNJ2, DRD4, DRD3, DRD2, CD82, ATP1B4
9	plasma membrane	GO:005886	INF	TPO, ANKH, F2, HSPG2, HSPB1, CADM1
10	axon	GO:030424	INF	ADRB2, , TGFB1, , SEMA3A,

Biological processes related to paralysis according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	synaptic transmission	GO:007268	INF	USP14, KCNC4, KCNJ2, KCNJ5, KCNK18,
2	muscle contraction	GO:006936	10.3	ANKRD2, RYR1, CACNA1S, SCN4A, GJA5, SCN7A
3	regulation of dopamine uptake involved in synaptic transmission	GO:051584	10.3	DRD2, DRD3, GDNF
4	locomotory behavior	GO:007626	10.3	GAA, SOD1, DRD3, DRD2, ANKH, ALS2
5	negative regulation of protein secretion	GO:050709	10.2	DRD4, DRD3, DRD2, INS
6	response to histamine	GO:034776	10.2	DRD2, DRD4, DRD3
7	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO:007195	10.1	DRD4, DRD3, DRD2
8	behavioral response to cocaine	GO:048148	10.1	DRD4, DRD3, DRD2
9	response to amphetamine	GO:001975	9.7	DRD2, DRD3, DRD4, SOD1
10	positive regulation of cytokine secretion	GO:050715	9.4	CADM1, IL10, INS, MIF
11	response to drug	GO:042493	INF	SS18, IL10, ATP1A1, TOP1, , BCHE
12	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	IL1B, ANKRD1, TGFB1, , GSX1, HOXB1
13	cell death	GO:008219	INF	TARDBP, , , , ,
14	phosphatidylcholine biosynthetic process	GO:006656	INF	ACHE, , CHKB, CHKA

Molecular functions related to paralysis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	sodium:potassium-exchanging ATPase activity	GO:005391	10.6	ATP1A1, ATP1A2, ATP1B1, ATP1B2
2	titin binding	GO:031432	10.4	TRIM63, ANKRD2, ANKRD1, TCAP
3	cholinesterase activity	GO:004104	10.3	CHKA, BCHE, ACHE
4	dopamine binding	GO:035240	10.2	ADRB2, DRD2, DRD3, DRD4
5	potassium channel regulator activity	GO:015459	10.1	DRD4, KCNE3, DRD2, ADRB2
6	dopamine receptor activity, coupled via Gi/Go	GO:001591	10.1	DRD3, DRD2, DRD4
7	drug binding	GO:008144	INF	DRD3, CHKA, DRD4, DRD2, , ADRB2
8	choline binding	GO:033265	INF	CHKA, BCHE,
9	protein binding	GO:005515	INF	CACNA1C, SNAP25, SSX2B, SS18, DRD4, DRD3