MCID: PRL008
MIFTS: 38

Paralytic Ileus

Categories: Gastrointestinal diseases

Aliases & Classifications for Paralytic Ileus

MalaCards integrated aliases for Paralytic Ileus:

Name: Paralytic Ileus 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8442
ICD10 32 K56.0
ICD9CM 34 560.1
MeSH 41 D007418
NCIt 46 C93045
SNOMED-CT 64 155773004 55525008
UMLS 69 C0030446

Summaries for Paralytic Ileus

MalaCards based summary : Paralytic Ileus is related to myeloma, multiple and intestinal pseudo-obstruction. An important gene associated with Paralytic Ileus is ABCB1 (ATP Binding Cassette Subfamily B Member 1), and among its related pathways/superpathways are Transport of vitamins, nucleosides, and related molecules and Gefitinib Pathway, Pharmacokinetics. The drugs Lidocaine and Magnesium oxide have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and kidney.

Related Diseases for Paralytic Ileus

Diseases related to Paralytic Ileus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 myeloma, multiple 29.3 ABCB1 ALB
2 intestinal pseudo-obstruction 11.7
3 peritonitis 10.3
4 koro 10.2 ABCB1 ALB
5 mitochondrial dna depletion syndrome 1 10.2 MT-TK TYMP
6 mitochondrial neurogastrointestinal encephalomyopathy 10.2 MT-TK TYMP
7 appendicitis 10.2
8 benign essential hypertension 10.2 ALB AVP
9 chronic progressive external ophthalmoplegia 10.2 MT-TK TYMP
10 syndrome of inappropriate antidiuretic hormone 10.2 ALB AVP
11 3-methylglutaconic aciduria, type v 10.2 MT-TK TYMP
12 analbuminemia 10.1 ALB AVP
13 leukemia 10.1
14 strongyloidiasis 10.1
15 intestinal obstruction 10.1
16 intussusception 10.1
17 meconium ileus 10.1
18 intestinal volvulus 10.1
19 intestinal impaction 10.1
20 hypothyroidism 10.1
21 pancreatitis 10.1
22 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 10.1 MT-TK TYMP
23 systemic lupus erythematosus 10.0
24 schizophrenia 10.0
25 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.0
26 thrombosis 10.0
27 acute pancreatitis 10.0
28 lupus erythematosus 10.0
29 urinary system disease 10.0 ALB AVP
30 opioid addiction 10.0 ABCB1 CCK
31 gastroparesis 9.9 ABCB1 CCK
32 cardiac arrest 9.9 ALB AVP
33 kearns-sayre syndrome 9.9 MT-TK TYMP
34 headache 9.9 ABCB1 CCK
35 pancreas disease 9.9 AVP CCK
36 ascending cholangitis 9.8 ALB CCK
37 blood group--diego system 9.8
38 blood group, i system 9.8
39 hepatocellular carcinoma 9.8
40 exudative vitreoretinopathy 1 9.8
41 hirschsprung disease 1 9.8
42 pheochromocytoma 9.8
43 protoporphyria, erythropoietic 9.8
44 thrombophilia due to thrombin defect 9.8
45 lung cancer 9.8
46 myxedema 9.8
47 aging 9.8
48 body mass index quantitative trait locus 1 9.8
49 myocardial infarction 9.8
50 acute promyelocytic leukemia 9.8

Comorbidity relations with Paralytic Ileus via Phenotypic Disease Network (PDN): (show top 50) (show all 80)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Acute Vascular Insufficiency of Intestine Alzheimer Disease
Anxiety Aortic Aneurysm
Ascending Colon Cancer Atrophic Gastritis
Bladder Cancer Bronchitis
Bronchopneumonia Candidiasis
Cecal Benign Neoplasm Cholangitis
Cholecystitis Cholestasis
Chronic Intestinal Vascular Insufficiency Chronic Kidney Failure
Chronic Myocardial Ischemia Chylomicron Retention Disease
Colorectal Cancer Cystitis
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Descending Colon Cancer
Duodenitis Dysthymic Disorder
Enterovesical Fistula Esophageal Disease
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hepatic Flexure Cancer Hydronephrosis
Hypertension, Essential Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypothyroidism Inflammatory Bowel Disease 1
Intestinal Disease Intestinal Obstruction
Intestinal Perforation Intestinal Volvulus
Iron Deficiency Anemia Irritable Bowel Syndrome
Ischemic Heart Disease Kidney Disease

Graphical network of the top 20 diseases related to Paralytic Ileus:



Diseases related to Paralytic Ileus

Symptoms & Phenotypes for Paralytic Ileus

Drugs & Therapeutics for Paralytic Ileus

Drugs for Paralytic Ileus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 139)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 1,Phase 2 137-58-6 3676
2
Magnesium oxide Approved Phase 4 1309-48-4 14792
3
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
4
Morphine Approved, Investigational Phase 4 57-27-2 5288826
5
Acetaminophen Approved Phase 4 103-90-2 1983
6
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
7
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
8
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
9
Methadone Approved Phase 4 76-99-3 4095
10
Orphenadrine Approved Phase 4 83-98-7 4601
11
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
12
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
13
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
14
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
15
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
16
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
17
Clonidine Approved Phase 4 4205-90-7 2803
18
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
19
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
20
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
21
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
22
Ranitidine Approved Phase 4 66357-59-3, 66357-35-5 3001055
23
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
24
Ondansetron Approved Phase 4 99614-02-5 4595
25
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
26
Peppermint Approved, Nutraceutical Phase 4
27
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
28 Central Nervous System Depressants Phase 4,Phase 1,Phase 2
29 Sodium Channel Blockers Phase 4,Phase 1,Phase 2
30 Cholinergic Agents Phase 4,Phase 1
31 Neurotransmitter Agents Phase 4,Phase 2,Phase 1
32 Anesthetics Phase 4,Phase 1,Phase 2
33 Anesthetics, Local Phase 4,Phase 1,Phase 2
34 Diuretics, Potassium Sparing Phase 4,Phase 1,Phase 2
35 Peripheral Nervous System Agents Phase 4,Phase 1,Phase 2
36 Anti-Arrhythmia Agents Phase 4,Phase 1,Phase 2
37 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
38 Autonomic Agents Phase 4,Phase 1
39 Cathartics Phase 4
40 Gastrointestinal Agents Phase 4
41 Antacids Phase 4
42 Laxatives Phase 4
43 Anti-Ulcer Agents Phase 4
44 Analgesics Phase 4
45 calcium channel blockers Phase 4
46 Respiratory System Agents Phase 4
47 Acetaminophen, hydrocodone drug combination Phase 4
48 Adjuvants, Anesthesia Phase 4
49 Muscarinic Antagonists Phase 4
50 Chlorpheniramine, phenylpropanolamine drug combination Phase 4

Interventional clinical trials:

(show all 30)

# Name Status NCT ID Phase Drugs
1 Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies Unknown status NCT01835119 Phase 4 gum
2 Effect of Postoperative Laxative on Bowel Function After Colonic Surgery Completed NCT00427492 Phase 4 Magnesia;Placebo
3 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery Recruiting NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
4 Early Oral Versus Enteral Nutrition After Pancreatoduodenectomy Recruiting NCT01642875 Phase 4
5 Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia Enrolling by invitation NCT02953210 Phase 4 dexter ketamine;Lidocaine Hydrochloride;Fentanyl Hydrochloride;Clonidine Hydrochloride;Midazolam Hydrochloride;Isoflurane Volatile Liquid;Rocuronium Injectable Solution;Propofol 1 % Injectable Suspension;Dexamethasone-21-Sulfobenzoate, Sodium Salt;Ranitidine Hydrochloride;Ondansetron Hydrochloride;Ketorolac Injectable Solution;Bupivacaine Hydrochloride
6 The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean Section Completed NCT01131416 Phase 2, Phase 3
7 Simo Decoction and Acupuncture on POI in Colorectal Cancer Completed NCT02813278 Phase 3
8 Effect of Smoked Plum and Chewing Gum on Postoperative Bowel Function Following Hepatic Resection Recruiting NCT02649153 Phase 3 smoked plum;gum chewing
9 Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer Withdrawn NCT01389986 Phase 2, Phase 3
10 Daikenchuto for Intestinal Dysmotility and Prevention of Postoperative Paralytic Ielus After Pancreaticoduodenectomy Unknown status NCT01607307 Phase 2 Oral/enteral TJ-100 solution;Oral/enteral placebo solution
11 Perioperative Systemic Lidocaine for Enhanced Bowel Recovery After Bariatric Surgery Unknown status NCT02607488 Phase 1, Phase 2 Placebo;Lidocaine 1%;Lidocaine 1.5%;Lidocaine 2%
12 Stimulation of the Efferent Loop Before Loop Ileostomy Closure Recruiting NCT03424447 Phase 2
13 UC-MSC Infusion for HBV-Related Acute-on-Chronic Liver Failure Not yet recruiting NCT02812121 Phase 2 umbilical cord blood mesenchymal stem cells
14 Acupuncture to Prevent Postoperative Bowel Paralysis (Paralytic Ileus) Terminated NCT00065234 Phase 2
15 Study of Inhaling Carbon Monoxide to Treat Patients With Intestinal Paralysis After Colon Surgery. Terminated NCT01050712 Phase 2 Inhaled Carbon Monoxide;Synthetic Air
16 Neostigmine Treatment of Acute Pancreatitis Combined With Intra-abdominal Hypertension Unknown status NCT02543658 Phase 1 Neostigmine;The traditional treatment
17 Effectiveness of Gum Chewing on Ileus in Chinese Colorectal Patients Underwent Laparoscopic Colorectal Surgery Unknown status NCT02419586
18 Is Nasogastric Tube Necessary After Pancreaticoduodenectomy? Unknown status NCT01966406
19 Is Nasogastric Tube Necessary After Pancreaticoduodenectomy? Unknown status NCT01991392
20 Effect of Chewing Gum on Postoperative Bowel Function Following Upper GI Tract Cancer Surgery Unknown status NCT02260128
21 Comparative Study of Laparoscopic Versus Open Operations for Colon Cancer Unknown status NCT00202111
22 Early Oral Feeding Versus Traditional Postoperative Care After Cesarean Section. Completed NCT02332278
23 Effects of Laser Acupuncture Therapy on Paralytic Ileus Recruiting NCT03041675
24 Short Versus Standard Post-operative Stay After Elective Cesarean Delivery Recruiting NCT03355378
25 Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated Colitis Recruiting NCT01959048 fecal microbiota transplantation
26 Neomycin and Metronidazole Hydrochloride With or Without Polyethylene Glycol in Reducing Infection in Patients Undergoing Elective Colorectal Surgery Recruiting NCT03042091 Early Phase 1 Polyethylene Glycol;Neomycin;Metronidazole Hydrochloride
27 Trial on Impact on the Hospital Stay, of an Early Oral Nutrition Protocol Applied to Patients After Total Gastrectomy. (DOPGT_2015) Not yet recruiting NCT03257280
28 Small Bowel Transit Time in Clostridium Difficile Colitis Terminated NCT01309750
29 Intracolonic Vancomycin Therapy in Severe C. Diff Colitis Terminated NCT01346059 Vancomycin;Saline
30 Neurostimulation for the Treatment of Post-Operative Ileus Withdrawn NCT00854074

Search NIH Clinical Center for Paralytic Ileus

Genetic Tests for Paralytic Ileus

Anatomical Context for Paralytic Ileus

MalaCards organs/tissues related to Paralytic Ileus:

38
Colon, Liver, Kidney, Small Intestine, Placenta, T Cells, Pancreas

Publications for Paralytic Ileus

Articles related to Paralytic Ileus:

(show top 50) (show all 201)
# Title Authors Year
1
Perception of Paralytic Ileus on Viewpoint of Avicenna. ( 28451547 )
2017
2
A rare case report of multiple myeloma presenting with paralytic ileus and type II respiratory failure due to hypercalcemic crisis. ( 29384906 )
2017
3
Paralytic Ileus Secondary to Methamphetamine Abuse: A Rare Case. ( 29082060 )
2017
4
Postoperative paralytic ileus remains a problem following surgery for advanced pelvic cancers. ( 28985845 )
2017
5
Paralytic ileus as the first presentation in type A acute aortic dissection. ( 28954997 )
2017
6
Paralytic ileus due to a novel anticancer drug, nab-paclitaxel: A case report. ( 27123288 )
2016
7
Clozapine-induced paralytic ileus. ( 26905889 )
2016
8
Vincristine-induced paralytic ileus during induction therapy of treatment protocols for acute lymphoblastic leukemia in adult patients. ( 27087157 )
2016
9
Strategy to reduce bortezomib-induced paralytic ileus in patients with myeloma and impaired renal function. ( 27899388 )
2016
10
Paralytic ileus after bilateral intravitreal injection of bevacizumab. ( 27146947 )
2016
11
Paralytic Ileus due to Superior Mesenteric Venous Thrombosis after Transarterial Injection for Hepatocellular Carcinoma. ( 26726083 )
2016
12
Effectiveness of afatinib in lung cancer with paralytic ileus due to peritoneal carcinomatosis. ( 28031832 )
2016
13
Reversal by the specific antidote, idarucizumab, of elevated dabigatran exposure in a patient with rectal perforation and paralytic ileus. ( 27543549 )
2016
14
Evaluation of the efficacy of daikenchuto (TJ -100) for the prevention of paralytic ileus after pancreaticoduodenectomy: A multicenter, double-blind, randomized, placebo-controlled trial. ( 26747224 )
2016
15
Paralytic ileus in the orthopaedic patient. ( 25917235 )
2015
16
Prevention of Paralytic Ileus Utilizing Alvimopan Following Spine Surgery. ( 26605031 )
2015
17
Efficacy and safety of low-dose celecoxib in reducing post-operative paralytic ileus after major abdominal surgery. ( 26780018 )
2015
18
Paralytic ileus following "subcutaneous bortezomib" therapy: focus on the clinical emergency-report of two cases. ( 25600700 )
2015
19
Perioperative administration of Daikenchuto (TJ-100) reduces the postoperative paralytic ileus in patients with pancreaticoduodenectomy. ( 25916084 )
2015
20
Paralytic Ileus and Prophylactic Gastrointestinal Motility Medication after Spinal Operation. ( 26446646 )
2015
21
Clozapine-induced paralytic ileus. ( 26400138 )
2015
22
High Incidence of Paralytic Ileus After Bortezomib Treatment of Antibody-Mediated Rejection in Kidney Transplant Recipients: Report of 2 Cases. ( 26492053 )
2015
23
Clozapine-induced paralytic ileus: a case report. ( 25083276 )
2014
24
Does gum chewing prevent postoperative paralytic ileus? ( 24841596 )
2014
25
Paralytic ileus associated with sodium valproate: a case report. ( 25006817 )
2014
26
Risperidone associated paralytic ileus in schizophrenia. ( 23833349 )
2013
27
Effect of Daikenchuto (TJ-100) on postoperative bowel motility and on prevention of paralytic ileus after pancreaticoduodenectomy: a multicenter, randomized, placebo-controlled phase II trial (the JAPAN-PD study). ( 23365113 )
2013
28
Ischiorectal abscess presenting as paralytic ileus. ( 25046892 )
2013
29
Definition, incidence, risk factors, and prevention of paralytic ileus following radical cystectomy: a systematic review. ( 23245816 )
2013
30
Use of neostigmine in capecitabine-induced paralytic ileus. ( 24362874 )
2013
31
Alvimopan for prevention of postoperative paralytic ileus in radical cystectomy patients: a cost-effectiveness analysis. ( 23171223 )
2013
32
Laparoscopic management for Seprafilm-induced sterile peritonitis with paralytic ileus: report of 2 cases. ( 22935311 )
2012
33
Hypercalcemic crisis due to adult T cell leukemia: a rare cause of paralytic ileus. ( 24714244 )
2012
34
An unusual case of paralytic ileus. ( 23150108 )
2012
35
Retroperitoneal paraganglioma manifesting as paralytic ileus: a case report. ( 22716303 )
2012
36
Paralytic ileus secondary to intestinal ascariasis. ( 23089427 )
2012
37
Methamphetamine-induced paralytic ileus. ( 22454809 )
2012
38
Using midthoracic epidural block for postoperative paralytic ileus. ( 23385046 )
2012
39
Treating a patient with intractable paralytic ileus using thoracic epidural analgesia. ( 22769863 )
2012
40
Ulcerative colitis presenting as acute infectious gastroenteritis with a paralytic ileus. ( 22605860 )
2012
41
Hypothyroidism causing paralytic ileus and acute kidney injury - case report. ( 21303532 )
2011
42
Paralytic ileus requiring hospitalization secondary to high-dose antipsychotic polypharmacy and benztropine. ( 21596217 )
2011
43
Paralytic ileus associated with use of diltiazem. ( 21785032 )
2011
44
Age and body mass index are independent risk factors for the development of postoperative paralytic ileus after radical cystectomy. ( 20472264 )
2010
45
Gitelman's syndrome presenting as recurrent paralytic ileus due to chronic renal tubular K+ wasting. ( 21117354 )
2010
46
Education and Imaging. Gastrointestinal: rectal sarcoidosis due to paralytic ileus resembling adult-onset Hirschsprung disease. ( 20659240 )
2010
47
The etiology and prevention of feeding intolerance paralytic ileus--revisiting an old concept. ( 19374754 )
2009
48
A 56-year-old woman with rash, paralytic ileus, and massive gastrointestinal bleeding. ( 19739959 )
2009
49
Cecal perforation due to paralytic ileus following primary caesarean section. ( 19327217 )
2009
50
Preventing paralytic ileus: can the anesthesiologist help. ( 19583062 )
2009

Variations for Paralytic Ileus

Expression for Paralytic Ileus

Search GEO for disease gene expression data for Paralytic Ileus.

Pathways for Paralytic Ileus

GO Terms for Paralytic Ileus

Biological processes related to Paralytic Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.13 AVP CCK TYMP
2 sodium-independent organic anion transport GO:0043252 8.62 ALB AVP

Molecular functions related to Paralytic Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.16 AVP CCK
2 oxygen binding GO:0019825 8.96 ALB CYP2C18
3 neuropeptide hormone activity GO:0005184 8.62 AVP CCK

Sources for Paralytic Ileus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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