MCID: PRL008
MIFTS: 37

Paralytic Ileus malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Paralytic Ileus

Aliases & Descriptions for Paralytic Ileus:

Name: Paralytic Ileus 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8442
ICD10 33 K56.0
ICD9CM 35 560.1
MeSH 42 D007418
NCIt 47 C93045
SNOMED-CT 64 155773004 55525008
UMLS 69 C0030446

Summaries for Paralytic Ileus

MalaCards based summary : Paralytic Ileus is related to intestinal pseudo-obstruction and peritonitis. An important gene associated with Paralytic Ileus is ABCB1 (ATP Binding Cassette Subfamily B Member 1), and among its related pathways/superpathways are G alpha (s) signalling events and Gefitinib Pathway, Pharmacokinetics. The drugs Magnesium oxide and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include kidney, small intestine and lung, and related phenotypes are nervous system and no phenotypic analysis

Related Diseases for Paralytic Ileus

Diseases related to Paralytic Ileus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Related Disease Score Top Affiliating Genes
1 intestinal pseudo-obstruction 11.2
2 peritonitis 10.2
3 visceral myopathy 10.1
4 intestinal volvulus 10.1
5 intussusception 10.1
6 appendicitis 10.1
7 ischemic neuropathy 10.1 ABCB1 CCK
8 infantile hypotonia 10.1 ABCB1 CCK
9 megalencephalic leukoencephalopathy with subcortical cysts 10.1 MT-TK TYMP
10 adult brain stem glioma 10.0 AVP CCK
11 leukemia 10.0
12 strongyloidiasis 10.0
13 intestinal obstruction 10.0
14 growth hormone deficiency, isolated partial 10.0 MT-TK TYMP
15 dyscalculia 10.0 MT-TK TYMP
16 typhoid fever 10.0 ABCB1 CCK
17 meconium ileus 10.0
18 intestinal impaction 10.0
19 chronic lacrimal gland enlargement 10.0 MT-TK TYMP
20 hypothyroidism 10.0
21 pancreatitis 10.0
22 chondroma 10.0 AVP CCK
23 myoclonic epilepsy associated with ragged-red fibers 9.9 MT-TK TYMP
24 schizophrenia 9.9
25 systemic lupus erythematosus 9.9
26 thrombosis 9.9
27 acute pancreatitis 9.9
28 lupus erythematosus 9.9
29 mental retardation with spastic paraplegia 9.8 MT-TK TYMP
30 pheochromocytoma 9.7
31 myocardial infarction 9.7
32 lung cancer 9.7
33 hepatocellular carcinoma 9.7
34 adult t-cell leukemia 9.7
35 gas gangrene 9.7
36 spinal cord injury 9.7
37 ulcerative colitis 9.7
38 paraganglioma 9.7
39 colitis 9.7
40 dermatomyositis 9.7
41 lymphoblastic leukemia 9.7
42 protein-losing enteropathy 9.7
43 henoch-schoenlein purpura 9.7
44 myxedema 9.7
45 dementia 9.7
46 pneumatosis cystoides intestinalis 9.7
47 interstitial cystitis 9.7
48 chronic interstitial cystitis 9.7
49 cystitis 9.7
50 constipation 9.7

Comorbidity relations with Paralytic Ileus via Phenotypic Disease Network (PDN): (show top 50) (show all 78)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Alzheimer Disease Anxiety Disorder
Aortic Aneurysm Ascending Colon Cancer
Atrophic Gastritis Bronchitis
Bronchopneumonia Candidiasis
Cecal Benign Neoplasm Cholangitis
Cholecystitis Cholestasis
Chronic Kidney Failure Chronic Myocardial Ischemia
Chylomicron Retention Disease Colorectal Cancer
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Descending Colon Cancer Duodenitis
Dysthymic Disorder Enterovesical Fistula
Esophageal Disease Esophagitis
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hepatic Flexure Cancer
Hydronephrosis Hypertension, Essential
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Hypothyroidism
Inflammatory Bowel Disease 1 Intestinal Disease
Intestinal Obstruction Intestinal Perforation
Intestinal Volvulus Iron Deficiency Anemia
Irritable Bowel Syndrome Ischemic Heart Disease
Kidney Disease Kwashiorkor
Mallory-Weiss Syndrome Marasmus

Graphical network of the top 20 diseases related to Paralytic Ileus:



Diseases related to Paralytic Ileus

Symptoms & Phenotypes for Paralytic Ileus

MGI Mouse Phenotypes related to Paralytic Ileus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.35 ABCB1 AVP CCK TAAR1 TYMP
2 no phenotypic analysis MP:0003012 8.92 ABCB1 AVP CCK TAAR1

Drugs & Therapeutics for Paralytic Ileus

Drugs for Paralytic Ileus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 141)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium oxide Approved Phase 4 1309-48-4 14792
2
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
3
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
4
Acetaminophen Approved Phase 4 103-90-2 1983
5
Lidocaine Approved, Vet_approved Phase 4,Phase 1,Phase 2 137-58-6 3676
6
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
7
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
8
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
9
Methadone Approved Phase 4 76-99-3 4095
10
Orphenadrine Approved Phase 4 83-98-7 4601
11
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
12
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
13
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
14
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
15
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
16
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
17
Clonidine Approved Phase 4 4205-90-7 2803
18
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
19
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
20
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
21
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
22
Ranitidine Approved Phase 4 66357-59-3, 66357-35-5 3001055
23
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
24
Ondansetron Approved Phase 4 99614-02-5 4595
25
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
26 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
27 Gastrointestinal Agents Phase 4
28 Antacids Phase 4
29 Laxatives Phase 4
30 Anti-Ulcer Agents Phase 4
31 Cathartics Phase 4
32 Analgesics Phase 4
33 calcium channel blockers Phase 4
34 Acetaminophen, hydrocodone drug combination Phase 4
35 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
36 Muscarinic Antagonists Phase 4
37 Cholinergic Agents Phase 4,Phase 1
38 Adjuvants, Anesthesia Phase 4
39 Cholinergic Antagonists Phase 4
40 Narcotics Phase 4
41 Neuromuscular Agents Phase 4
42 Sodium Channel Blockers Phase 4,Phase 1,Phase 2
43 Neurotransmitter Agents Phase 4,Phase 2,Phase 1
44 Cyclooxygenase Inhibitors Phase 4
45 Cytochrome P-450 Enzyme Inhibitors Phase 4
46 Analgesics, Non-Narcotic Phase 4
47 Analgesics, Opioid Phase 4
48 Tranquilizing Agents Phase 4
49 Anesthetics Phase 4,Phase 1,Phase 2
50 Parasympatholytics Phase 4

Interventional clinical trials:

(show all 27)
id Name Status NCT ID Phase
1 Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies Unknown status NCT01835119 Phase 4
2 Effect of Postoperative Laxative on Bowel Function After Colonic Surgery Completed NCT00427492 Phase 4
3 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery Recruiting NCT02958566 Phase 4
4 Early Oral Versus Enteral Nutrition After Pancreatoduodenectomy Recruiting NCT01642875 Phase 4
5 Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia Enrolling by invitation NCT02953210 Phase 4
6 The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean Section Completed NCT01131416 Phase 2, Phase 3
7 Simo Decoction and Acupuncture on POI in Colorectal Cancer Completed NCT02813278 Phase 3
8 Effect of Smoked Plum and Chewing Gum on Postoperative Bowel Function Following Hepatic Resection Recruiting NCT02649153 Phase 3
9 Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer Withdrawn NCT01389986 Phase 2, Phase 3
10 Daikenchuto for Intestinal Dysmotility and Prevention of Postoperative Paralytic Ielus After Pancreaticoduodenectomy Unknown status NCT01607307 Phase 2
11 Perioperative Systemic Lidocaine for Enhanced Bowel Recovery After Bariatric Surgery Recruiting NCT02607488 Phase 1, Phase 2
12 UC-MSC Infusion for HBV-Related Acute-on-Chronic Liver Failure Not yet recruiting NCT02812121 Phase 2
13 Acupuncture to Prevent Postoperative Bowel Paralysis (Paralytic Ileus) Terminated NCT00065234 Phase 2
14 Study of Inhaling Carbon Monoxide to Treat Patients With Intestinal Paralysis After Colon Surgery. Terminated NCT01050712 Phase 2
15 Neurostimulation for the Treatment of Post-Operative Ileus Withdrawn NCT00854074 Phase 2
16 Neostigmine Treatment of Acute Pancreatitis Combined With Intra-abdominal Hypertension Not yet recruiting NCT02543658 Phase 1
17 Effectiveness of Gum Chewing on Ileus in Chinese Colorectal Patients Underwent Laparoscopic Colorectal Surgery Unknown status NCT02419586
18 Is Nasogastric Tube Necessary After Pancreaticoduodenectomy? Unknown status NCT01966406
19 Is Nasogastric Tube Necessary After Pancreaticoduodenectomy? Unknown status NCT01991392
20 Effect of Chewing Gum on Postoperative Bowel Function Following Upper GI Tract Cancer Surgery Unknown status NCT02260128
21 Comparative Study of Laparoscopic Versus Open Operations for Colon Cancer Unknown status NCT00202111
22 Early Oral Feeding Versus Traditional Postoperative Care After Cesarean Section. Completed NCT02332278
23 Effects of Laser Acupuncture Therapy on Paralytic Ileus Recruiting NCT03041675
24 Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated Colitis Recruiting NCT01959048
25 Neomycin and Metronidazole Hydrochloride With or Without Polyethylene Glycol in Reducing Infection in Patients Undergoing Elective Colorectal Surgery Recruiting NCT03042091 Early Phase 1
26 Small Bowel Transit Time in Clostridium Difficile Colitis Terminated NCT01309750
27 Intracolonic Vancomycin Therapy in Severe C. Diff Colitis Terminated NCT01346059

Search NIH Clinical Center for Paralytic Ileus

Genetic Tests for Paralytic Ileus

Anatomical Context for Paralytic Ileus

MalaCards organs/tissues related to Paralytic Ileus:

39
Kidney, Small Intestine, Lung, T Cells, Liver, Placenta, Pancreas

Publications for Paralytic Ileus

Articles related to Paralytic Ileus:

(show top 50) (show all 196)
id Title Authors Year
1
Evaluation of the efficacy of daikenchuto (TJ -100) for the prevention of paralytic ileus after pancreaticoduodenectomy: A multicenter, double-blind, randomized, placebo-controlled trial. ( 26747224 )
2016
2
Paralytic Ileus due to Superior Mesenteric Venous Thrombosis after Transarterial Injection for Hepatocellular Carcinoma. ( 26726083 )
2016
3
Effectiveness of afatinib in lung cancer with paralytic ileus due to peritoneal carcinomatosis. ( 28031832 )
2016
4
Reversal by the specific antidote, idarucizumab, of elevated dabigatran exposure in a patient with rectal perforation and paralytic ileus. ( 27543549 )
2016
5
Vincristine-induced paralytic ileus during induction therapy of treatment protocols for acute lymphoblastic leukemia in adult patients. ( 27087157 )
2016
6
Paralytic ileus after bilateral intravitreal injection of bevacizumab. ( 27146947 )
2016
7
Paralytic ileus due to a novel anticancer drug, nab-paclitaxel: A case report. ( 27123288 )
2016
8
Clozapine-induced paralytic ileus. ( 26905889 )
2016
9
Strategy to reduce bortezomib-induced paralytic ileus in patients with myeloma and impaired renal function. ( 27899388 )
2016
10
Paralytic ileus following "subcutaneous bortezomib" therapy: focus on the clinical emergency-report of two cases. ( 25600700 )
2015
11
Prevention of Paralytic Ileus Utilizing Alvimopan Following Spine Surgery. ( 26605031 )
2015
12
Paralytic ileus in the orthopaedic patient. ( 25917235 )
2015
13
Perioperative administration of Daikenchuto (TJ-100) reduces the postoperative paralytic ileus in patients with pancreaticoduodenectomy. ( 25916084 )
2015
14
Efficacy and safety of low-dose celecoxib in reducing post-operative paralytic ileus after major abdominal surgery. ( 26780018 )
2015
15
High Incidence of Paralytic Ileus After Bortezomib Treatment of Antibody-Mediated Rejection in Kidney Transplant Recipients: Report of 2 Cases. ( 26492053 )
2015
16
Paralytic Ileus and Prophylactic Gastrointestinal Motility Medication after Spinal Operation. ( 26446646 )
2015
17
Clozapine-induced paralytic ileus. ( 26400138 )
2015
18
Clozapine-induced paralytic ileus: a case report. ( 25083276 )
2014
19
Does gum chewing prevent postoperative paralytic ileus? ( 24841596 )
2014
20
Paralytic ileus associated with sodium valproate: a case report. ( 25006817 )
2014
21
Definition, incidence, risk factors, and prevention of paralytic ileus following radical cystectomy: a systematic review. ( 23245816 )
2013
22
Risperidone associated paralytic ileus in schizophrenia. ( 23833349 )
2013
23
Ischiorectal abscess presenting as paralytic ileus. ( 25046892 )
2013
24
Use of neostigmine in capecitabine-induced paralytic ileus. ( 24362874 )
2013
25
Effect of Daikenchuto (TJ-100) on postoperative bowel motility and on prevention of paralytic ileus after pancreaticoduodenectomy: a multicenter, randomized, placebo-controlled phase II trial (the JAPAN-PD study). ( 23365113 )
2013
26
Alvimopan for prevention of postoperative paralytic ileus in radical cystectomy patients: a cost-effectiveness analysis. ( 23171223 )
2013
27
Ulcerative colitis presenting as acute infectious gastroenteritis with a paralytic ileus. ( 22605860 )
2012
28
Retroperitoneal paraganglioma manifesting as paralytic ileus: a case report. ( 22716303 )
2012
29
Laparoscopic management for Seprafilm-induced sterile peritonitis with paralytic ileus: report of 2 cases. ( 22935311 )
2012
30
An unusual case of paralytic ileus. ( 23150108 )
2012
31
Treating a patient with intractable paralytic ileus using thoracic epidural analgesia. ( 22769863 )
2012
32
Using midthoracic epidural block for postoperative paralytic ileus. ( 23385046 )
2012
33
Methamphetamine-induced paralytic ileus. ( 22454809 )
2012
34
Paralytic ileus secondary to intestinal ascariasis. ( 23089427 )
2012
35
Hypercalcemic crisis due to adult T cell leukemia: a rare cause of paralytic ileus. ( 24714244 )
2012
36
Paralytic ileus requiring hospitalization secondary to high-dose antipsychotic polypharmacy and benztropine. ( 21596217 )
2011
37
Paralytic ileus associated with use of diltiazem. ( 21785032 )
2011
38
Hypothyroidism causing paralytic ileus and acute kidney injury - case report. ( 21303532 )
2011
39
Gitelman's syndrome presenting as recurrent paralytic ileus due to chronic renal tubular K+ wasting. ( 21117354 )
2010
40
Age and body mass index are independent risk factors for the development of postoperative paralytic ileus after radical cystectomy. ( 20472264 )
2010
41
Education and Imaging. Gastrointestinal: rectal sarcoidosis due to paralytic ileus resembling adult-onset Hirschsprung disease. ( 20659240 )
2010
42
Systematic review and meta-analysis of chewing-gum therapy in the reduction of postoperative paralytic ileus following gastrointestinal surgery. ( 19763686 )
2009
43
Paralytic ileus and liver failure--an unusual presentation of advanced erythropoietic protoporphyria. ( 19009347 )
2009
44
Preventing paralytic ileus: can the anesthesiologist help. ( 19583062 )
2009
45
Paralytic ileus possibly associated with interaction between ritonavir/lopinavir and vincristine. ( 19757141 )
2009
46
Continuous intravenous lidocaine in the treatment of paralytic ileus due to severe spinal cord injury. ( 18945248 )
2009
47
A 56-year-old woman with rash, paralytic ileus, and massive gastrointestinal bleeding. ( 19739959 )
2009
48
Cecal perforation due to paralytic ileus following primary caesarean section. ( 19327217 )
2009
49
The etiology and prevention of feeding intolerance paralytic ileus--revisiting an old concept. ( 19374754 )
2009
50
Paralytic ileus and subsequent death caused by enteric parasite, Strongyloides papillosus, in Mongolian gerbils. ( 19303216 )
2009

Variations for Paralytic Ileus

Expression for Paralytic Ileus

Search GEO for disease gene expression data for Paralytic Ileus.

Pathways for Paralytic Ileus

GO Terms for Paralytic Ileus

Biological processes related to Paralytic Ileus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of glutamate secretion GO:0014049 8.62 AVP CCK

Molecular functions related to Paralytic Ileus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 AVP CCK
2 neuropeptide hormone activity GO:0005184 8.62 AVP CCK

Sources for Paralytic Ileus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....