MCID: PRL013
MIFTS: 28

Paralytic Poliomyelitis malady

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Paralytic Poliomyelitis

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Aliases & Descriptions for Paralytic Poliomyelitis:

Name: Paralytic Poliomyelitis 11 13
 
Poliomyelitis, Paralytic 68

Classifications:



External Ids:

Disease Ontology11 DOID:0050515

Summaries for Paralytic Poliomyelitis

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Disease Ontology:11 A poliomyelitis that results in destruction located in motor neurons of central nervous system, has material basis in Human poliovirus 1, has material basis in Human poliovirus 2, or has material basis in Human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. The infection has symptom loss of reflexes, has symptom muscle spasms, and has symptom acute flaccid paralysis.

MalaCards based summary: Paralytic Poliomyelitis, also known as poliomyelitis, paralytic, is related to poliomyelitis and spinal polio, and has symptoms including loss of reflexes, muscle spasms and acute flaccid paralysis. An important gene associated with Paralytic Poliomyelitis is PVR (Poliovirus Receptor), and among its related pathways are G12-G13 in Cellular Signaling and Platelet activation. Affiliated tissues include motor neurons of central nervous system, spinal cord and bone.

Related Diseases for Paralytic Poliomyelitis

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Graphical network of the top 20 diseases related to Paralytic Poliomyelitis:



Diseases related to paralytic poliomyelitis

Symptoms & Phenotypes for Paralytic Poliomyelitis

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Symptoms:

 11
  • loss of reflexes
  • muscle spasms
  • acute flaccid paralysis

Drugs & Therapeutics for Paralytic Poliomyelitis

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Drugs for Paralytic Poliomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 36428

Interventional clinical trials:

idNameStatusNCT IDPhase
1Polio End-game Strategies - Poliovirus Type 2 Challenge StudyCompletedNCT02189811Phase 4
2Randomized Controlled Trial for Immunogenicity and Safety Evaluation of Bivalent Types 1 and 3 Oral Poliovirus VaccineCompletedNCT02785705Phase 3
3Study of Mental Fatigue in Polio SurvivorsUnknown statusNCT00487487

Search NIH Clinical Center for Paralytic Poliomyelitis

Genetic Tests for Paralytic Poliomyelitis

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Anatomical Context for Paralytic Poliomyelitis

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MalaCards organs/tissues related to Paralytic Poliomyelitis:

36
Spinal cord, Bone

FMA organs/tissues related to Paralytic Poliomyelitis:

17
Motor neurons of central nervous system

Publications for Paralytic Poliomyelitis

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Articles related to Paralytic Poliomyelitis:

(show top 50)    (show all 353)
idTitleAuthorsYear
1
A cluster of paralytic poliomyelitis cases due to transmission of slightly diverged Sabin-2 vaccine virus. (27099315)
2016
2
Vaccine associated paralytic poliomyelitis cases from children presenting with acute flaccid paralysis in Uganda. (26058454)
2015
3
Circadian variation of fatigue in paralytic poliomyelitis and postpolio syndrome: just fatigue or masked restless legs syndrome? (24964120)
2014
4
Outbreaks of paralytic poliomyelitis during 1996-2012: the changing epidemiology of a disease in the final stages of eradication. (25316846)
2014
5
Examination of motor unit control properties of the vastus lateralis in an individual that had acute paralytic poliomyelitis. (25083857)
2014
6
Vaccine-associated paralytic poliomyelitis: a case report. (24647260)
2014
7
An unusual case of vaccine-associated paralytic poliomyelitis. (25285130)
2014
8
Vaccine-associated paralytic poliomyelitis: a review of the epidemiology and estimation of the global burden. (25316859)
2014
9
Effectiveness of oral polio vaccination against paralytic poliomyelitis: a matched case-control study in somalia. (25316835)
2014
10
Vaccine-associated paralytic poliomyelitis and BCG-osis in an immigrant child with severe combined immunodeficiency syndrome - Texas, 2013. (25144542)
2014
11
Vaccine-associated paralytic poliomyelitis in the postelimination era in Latin America and the Caribbean, 1992-2011. (24520126)
2014
12
Combined immunodeficiency presenting with vaccine-associated paralytic poliomyelitis: a case report and narrative review of literature. (24294834)
2013
13
Children with paralytic poliomyelitis: utilization of physiotherapy services in Zamfara State, Nigeria. (22871225)
2013
14
Circadian variation of fatigue in both patients with paralytic poliomyelitis and post-polio syndrome. (23857622)
2013
15
Children with paralytic poliomyelitis: a cross-sectional study of knowledge, attitudes and beliefs of parents in Zamfara state, Nigeria. (23083466)
2012
16
Risks associated with the use of live-attenuated vaccine poliovirus strains and the strategies for control and eradication of paralytic poliomyelitis. (22827246)
2012
17
Vaccine-associated paralytic poliomyelitis in Japan. (22325660)
2012
18
Apropos risks associated with the use of live-attenuated vaccine poliovirus strains and the strategies for control and eradication of paralytic poliomyelitis. (23249227)
2012
19
Paralytic poliomyelitis associated with Sabin monovalent and bivalent oral polio vaccines in Hungary. (21685412)
2011
20
Vaccine-associated paralytic poliomyelitis in immunodeficient children, Iran, 1995-2008. (20587188)
2010
21
Vaccine-associated paralytic poliomyelitis in an infant with perianal abscesses. (20449625)
2010
22
Vaccine-associated paralytic poliomyelitis in a non-immunocompromised infant. (20880307)
2010
23
MR finding in vaccine-associated paralytic poliomyelitis. (20567967)
2010
24
A case of paralytic poliomyelitis associated with poliovirus vaccine strains in Hokkaido, Japan. (20495280)
2010
25
Molecular characterization of poliovirus isolates from children who contracted vaccine-associated paralytic poliomyelitis (VAPP) following administration of monovalent type 3 oral poliovirus vaccine in the 1960s in Hungary. (19863665)
2010
26
MRI findings in an infant with vaccine-associated paralytic poliomyelitis. (20440488)
2010
27
Three cases of paralytic poliomyelitis associated with type 3 vaccine poliovirus strains in Bulgaria. (19626606)
2009
28
Ala67Thr mutation in the poliovirus receptor CD155 is a potential risk factor for vaccine and wild-type paralytic poliomyelitis. (19319949)
2009
29
Vaccine - associated paralytic poliomyelitis in a pre-vaccinated infant. (18626544)
2008
30
Effectiveness of immunization against paralytic poliomyelitis in Nigeria. (18923171)
2008
31
Paralytic poliomyelitis during the pre-, peri- and post-suspension periods of a polio immunization campaign. (18628551)
2008
32
Vaccine-associated paralytic poliomyelitis in a pre-vaccinated infant. (18998027)
2008
33
Poisson-model analysis of the risk of vaccine-associated paralytic poliomyelitis in Japan between 1971 and 2000. (18362395)
2008
34
Novel BTK mutation presenting with vaccine-associated paralytic poliomyelitis. (18317803)
2008
35
Vaccine-associated paralytic poliomyelitis: a case report of flaccid monoparesis after oral polio vaccine. (17449951)
2007
36
Characterization of mutations in the VP(1) region of Sabin strain type 1 polioviruses isolated from vaccine-associated paralytic poliomyelitis cases in Iran. (17590391)
2007
37
Vaccine-associated paralytic poliomyelitis in a patient with MHC class II deficiency. (17509935)
2007
38
Imported vaccine-associated paralytic poliomyelitis--United States, 2005. (16456525)
2006
39
Vaccine-associated paralytic poliomyelitis caused by contact infection. (16617188)
2006
40
Cellular and humoral immunodeficiency in children with vaccine-associated paralytic poliomyelitis]. (17297880)
2006
41
No evidence for prolonged excretion of polioviruses in persons with residual paralytic poliomyelitis in Ethiopia, Pakistan and Guatemala. (16682222)
2006
42
Clinical presentations of acute paralytic poliomyelitis. (16386337)
2006
43
Clinical presentations of acute paralytic poliomyelitis. (15970362)
2005
44
Strength and endurance of knee extensors in subjects after paralytic poliomyelitis. (16096231)
2005
45
Incidence of adaptive equipment use in subjects with a remote history of paralytic poliomyelitis. (16186550)
2005
46
Framework for evaluating the risks of paralytic poliomyelitis after global interruption of wild poliovirus transmission. (15106299)
2004
47
Electrodiagnostic features of acute paralytic poliomyelitis associated with West Nile virus infection. (14981736)
2004
48
A developing country perspective on vaccine-associated paralytic poliomyelitis. (15106301)
2004
49
Paralytic poliomyelitis caused by a vaccine-derived polio virus in an antibody-deficient Argentinean child. (12828159)
2003
50
Vaccine-associated paralytic poliomyelitis and other diseases with acute flaccid paralysis syndrome in Belarus. (14768785)
2003

Variations for Paralytic Poliomyelitis

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Expression for genes affiliated with Paralytic Poliomyelitis

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Search GEO for disease gene expression data for Paralytic Poliomyelitis.

Pathways for genes affiliated with Paralytic Poliomyelitis

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Pathways related to Paralytic Poliomyelitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.4ARHGEF1, BTK
29.4ARHGEF1, BTK

GO Terms for genes affiliated with Paralytic Poliomyelitis

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Sources for Paralytic Poliomyelitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet