MCID: PRL013
MIFTS: 38

Paralytic Poliomyelitis malady

Infectious diseases, Neuronal diseases categories

Summaries for Paralytic Poliomyelitis

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A poliomyelitis that results in destruction located in motor neurons of central nervous system, has material basis in human poliovirus 1, has material basis in human poliovirus 2, or has material basis in human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. the infection has symptom loss of reflexes, has symptom muscle spasms, and has symptom acute flaccid paralysis.

MalaCards: Paralytic Poliomyelitis is related to poliomyelitis and agammaglobulinemia, and has symptoms including loss of reflexes, muscle spasms and acute flaccid paralysis. An important gene associated with Paralytic Poliomyelitis is PVR (poliovirus receptor), and among its related pathways are Cell adhesion molecules (CAMs) and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The compounds ivig and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include motor neurons of central nervous system, spinal cord and breast, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Aliases & Classifications for Paralytic Poliomyelitis

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9Disease Ontology
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

paralytic poliomyelitis 9


External Ids:

Disease Ontology9 DOID:0050515

Related Diseases for Paralytic Poliomyelitis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Paralytic Poliomyelitis:



Diseases related to paralytic poliomyelitis

Symptoms for Paralytic Poliomyelitis

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9Disease Ontology
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Symptoms:

9
  • loss of reflexes
  • muscle spasms
  • acute flaccid paralysis

Drugs & Therapeutics for Paralytic Poliomyelitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Paralytic Poliomyelitis

Search CenterWatch for Paralytic Poliomyelitis

Genetic Tests for Paralytic Poliomyelitis

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Anatomical Context for Paralytic Poliomyelitis

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Paralytic Poliomyelitis:

34
Spinal cord, Breast, Bone

FMA organs/tissues related to Paralytic Poliomyelitis:

15
Motor neurons of central nervous system

Animal Models for Paralytic Poliomyelitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Paralytic Poliomyelitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.5CD40LG, BTK, PVR
2MP:00053978.4CD40LG, BTK, PVR
3MP:00053878.2CD40LG, BTK, PVR

Publications for Paralytic Poliomyelitis

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53PubMed
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Articles related to Paralytic Poliomyelitis:

(show top 50)    (show all 340)
idTitleAuthorsYear
1
Vaccine-associated paralytic poliomyelitis in immunodeficient children, Iran, 1995-2008. (20587188)
2010
2
MR finding in vaccine-associated paralytic poliomyelitis. (20567967)
2010
3
A case of paralytic poliomyelitis associated with poliovirus vaccine strains in Hokkaido, Japan. (20495280)
2010
4
Ala67Thr mutation in the poliovirus receptor CD155 is a potential risk factor for vaccine and wild-type paralytic poliomyelitis. (19319949)
2009
5
Clinical presentations of acute paralytic poliomyelitis. (16386337)
2006
6
Paralytic poliomyelitis caused by a vaccine-derived polio virus in an antibody-deficient Argentinean child. (12828159)
2003
7
The neuropathology observed in wild-type mice inoculated with human poliovirus mirrors human paralytic poliomyelitis. (12220986)
2002
8
A case of vaccine-associated paralytic poliomyelitis. (11291633)
2001
9
Amyotrophic lateral sclerosis in an adult following acute paralytic poliomyelitis in early childhood. (10090681)
1999
10
Vaccine-associated paralytic poliomyelitis. (8989358)
1997
11
Epidemiological considerations on age distribution of paralytic poliomyelitis. (8816037)
1996
12
Immunization status in hospitalized children with acute paralytic poliomyelitis. (8935263)
1995
13
Completeness of reporting for paralytic poliomyelitis, United States, 1980 through 1991. Implications for estimating the risk of vaccine-associated disease. (8180638)
1994
14
Paralytic poliomyelitis in Romania, 1984-1992. Evidence for a high risk of vaccine-associated disease and reintroduction of wild-virus infection. (7998593)
1994
15
Acute paralytic poliomyelitis in Delhi (1975-1992). (7927614)
1994
16
Ataxia-telangiectasia in a child with vaccine-associated paralytic poliomyelitis. (1517916)
1992
17
Update: eradication of paralytic poliomyelitis in the Americas. (1381040)
1992
18
Paralytic poliomyelitis. (1538863)
1992
19
AAEM case report #23: acute paralytic poliomyelitis. (1766446)
1991
20
Prevalence of paralytic poliomyelitis in a rural and urban community of Delhi. (2286434)
1990
21
Impact of annual immunisation programme with oral polio vaccine on the prevalence of paralytic poliomyelitis. (2807469)
1989
22
Paralytic poliomyelitis in vaccinated children. (3683754)
1987
23
Imported paralytic poliomyelitis--United States, 1986. (3095620)
1986
24
Paralytic poliomyelitis in children in Ethiopia: a review of 2604 cases. (3698975)
1986
25
Outbreak of paralytic poliomyelitis. (2857255)
1985
26
Paralytic poliomyelitis in Finland. (2863531)
1985
27
Paralytic poliomyelitis in children: some facts and figures from a hospital at Calcutta--1. (3835135)
1985
28
Antigenic analysis of polioviruses isolated from a child with agammaglobulinemia and paralytic poliomyelitis after Sabin vaccine administration. (6273701)
1981
29
A study of incidence of paralytic poliomyelitis in Bhopal: agglomeration from 1972-78. (7262985)
1981
30
Comparison of methods for estimating the frequency of paralytic poliomyelitis in developing countries. (312162)
1979
31
Observations on economic impact of paralytic poliomyelitis in children. (544523)
1979
32
Paralytic poliomyelitis in children. (924651)
1977
33
Acute paralytic poliomyelitis at Kenyatta National Hospital 1969-1971. (4845811)
1974
34
Guest editorial: outbreak of paralytic poliomyelitis. (4687474)
1973
35
Role of breast feeding in paralytic poliomyelitis with special reference to immunisation. (5028650)
1972
36
Surveillance of paralytic poliomyelitis in the United States. 1966 and 1967 cases, and 1965-1967 cases associated with oral poliovirus vaccine. (4309925)
1969
37
Studies on paralytic poliomyelitis in Cairo, U.A.R., 1957-1958. (13792243)
1960
38
Preconceptions about vaccination against paralytic poliomyelitis. (13637560)
1959
39
Recurrent paralytic poliomyelitis; report of a case, documented with virus isolations. (13657362)
1959
40
Are-assessment of the risk of provoking paralytic poliomyelitis by making prophylactic inoculations against diphtheria and pertussis. (13664982)
1959
41
Paralytic Poliomyelitis in Canada, Week ending October 4, 1958. (20325819)
1958
42
Prognosis of limb inequality following paralytic poliomyelitis. (13612205)
1958
43
A severe epidemic of paralytic poliomyelitis in western province of Tanganyika, 1956. (13502901)
1958
44
Study of cases of paralytic poliomyelitis in triply-vaccinated persons. (13569855)
1958
45
C reactive protein in serous meningitis and paralytic poliomyelitis. (13470510)
1957
46
Glossopharyngeal breathing as an aid to recovery from paralytic poliomyelitis. (13313534)
1956
47
Paralytic poliomyelitis. (14371167)
1955
48
Observations on the use of gamma globulin as a control measure in paralytic poliomyelitis in siblings; report of two cases. (13213643)
1954
49
POSSIBLE relationship between paralytic poliomyelitis and subcutaneous injection of immunizing agents and other medicinal substances. (14911309)
1952
50
An epidemic of paralytic poliomyelitis characterized by dual infections with poliomyelitis and Coxsackie viruses. (14897994)
1951

Variations for Paralytic Poliomyelitis

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Expression for genes affiliated with Paralytic Poliomyelitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paralytic Poliomyelitis

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Pathways for genes affiliated with Paralytic Poliomyelitis

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51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 58SinoBiological, 55R&D Systems, 54QIAGEN
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Compounds for genes affiliated with Paralytic Poliomyelitis

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46Novoseek, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 3BitterDB, 12DrugBank
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Compounds related to Paralytic Poliomyelitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ivig469.2CD40LG, BTK
2ionomycin469.2CD40LG, BTK
3fibrinogen469.1CD40LG, BTK
4arginine469.1CD40LG, BTK
5histamine46 30 2511.0BTK, CD40LG
6genistein46 30 62 3 25 1213.8CD40LG, BTK

GO Terms for genes affiliated with Paralytic Poliomyelitis

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17Gene Ontology
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Cellular components related to Paralytic Poliomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.5CD40LG, BTK, PVR

Biological processes related to Paralytic Poliomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:0507769.3CD40LG, PVR

Products for genes affiliated with Paralytic Poliomyelitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Paralytic Poliomyelitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet