MCID: PRL013
MIFTS: 27

Paralytic Poliomyelitis malady

Summaries for Paralytic Poliomyelitis

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A poliomyelitis that results in destruction located in motor neurons of central nervous system, has material basis in human poliovirus 1, has material basis in human poliovirus 2, or has material basis in human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. the infection has symptom loss of reflexes, has symptom muscle spasms, and has symptom acute flaccid paralysis.

MalaCards: Paralytic Poliomyelitis is related to agammaglobulinemia and spinal polio, and has symptoms including loss of reflexes, muscle spasms and acute flaccid paralysis. An important gene associated with Paralytic Poliomyelitis is PVR (poliovirus receptor), and among its related pathways are Cell adhesion molecules (CAMs) and TNF Signaling. The compounds ionomycin and ivig have been mentioned in the context of this disorder. Affiliated tissues include motor neurons of central nervous system.

Aliases & Classifications for Paralytic Poliomyelitis

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8Disease Ontology
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Aliases & Descriptions:

paralytic poliomyelitis 8


External Ids:

Disease Ontology8 DOID:0050515

Related Diseases for Paralytic Poliomyelitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Paralytic Poliomyelitis:



Diseases related to paralytic poliomyelitis

Clinical Features for Paralytic Poliomyelitis

Sources:
8Disease Ontology
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Symptoms:

8
  • loss of reflexes
  • muscle spasms
  • acute flaccid paralysis

Drugs & Therapeutics for Paralytic Poliomyelitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Paralytic Poliomyelitis

Drug clinical trials:

Search ClinicalTrials for Paralytic Poliomyelitis

Search NIH Clinical Center for Paralytic Poliomyelitis

Search CenterWatch for Paralytic Poliomyelitis

Genetic Tests for Paralytic Poliomyelitis

Anatomical Context for Paralytic Poliomyelitis

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14FMA
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FMA organs/tissues related to Paralytic Poliomyelitis:

14
Motor neurons of central nervous system

Animal Models for Paralytic Poliomyelitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Paralytic Poliomyelitis

Sources:
51PubMed
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Articles related to Paralytic Poliomyelitis:

(show top 50)    (show all 348)
idTitleAuthorsYear
1
Circadian variation of fatigue in both patients with paralytic poliomyelitis and post-polio syndrome. (23857622)
2013
2
Vaccine-associated paralytic poliomyelitis in Japan. (22325660)
2012
3
Vaccine-associated paralytic poliomyelitis in immunodeficient children, Iran, 1995-2008. (20587188)
2010
4
MRI findings in an infant with vaccine-associated paralytic poliomyelitis. (20440488)
2010
5
Vaccine-associated paralytic poliomyelitis in a patient with MHC class II deficiency. (17509935)
2007
6
Framework for evaluating the risks of paralytic poliomyelitis after global interruption of wild poliovirus transmission. (15106299)
2004
7
Isolation of an intertypic poliovirus capsid recombinant from a child with vaccine-associated paralytic poliomyelitis. (12368335)
2002
8
Vaccine-associated paralytic poliomyelitis: a retrospective cohort study of acute flaccid paralyses in Brazil. (10922356)
2000
9
Fibrillation potentials and positive sharp waves in patients with antecedent paralytic poliomyelitis. (9842478)
1998
10
OPV vs IPV--could placental immunity reduce the number of vaccine-associated paralytic poliomyelitis? (9364670)
1997
11
Vaccine-associated paralytic poliomyelitis. (8604208)
1996
12
Evidence for persistent enterovirus infection of the central nervous system in patients with previous paralytic poliomyelitis. (7611631)
1995
13
Vaccine-associated paralytic poliomyelitis. (7476613)
1995
14
Paralytic poliomyelitis in Romania, 1984-1992. Evidence for a high risk of vaccine-associated disease and reintroduction of wild-virus infection. (7998593)
1994
15
Intramuscular injection as a provocative factor in paralytic poliomyelitis. (7875883)
1994
16
Vaccine-associated paralytic poliomyelitis. (8350905)
1993
17
More on vaccine-associated paralytic poliomyelitis. (8247068)
1993
18
Management of common Third World orthopaedic problems: paralytic poliomyelitis, tuberculosis of bones and joints, Hansen's disease (leprosy), and chronic osteomyelitis. (1588097)
1992
19
Sero-epidemiological study of severe forms of paralytic poliomyelitis. (1660856)
1991
20
Outbreak of paralytic poliomyelitis in Oman: evidence for widespread transmission among fully vaccinated children. (1679866)
1991
21
Paralytic poliomyelitis in rural Kashmir. (2599617)
1989
22
An epidemiological study of paralytic poliomyelitis cases in Kasturba Hospital, Manipal. (2614046)
1989
23
Preliminary report: paralytic poliomyelitis--Senegal, 1986. (3108650)
1987
24
Paralytic poliomyelitis in children in Ethiopia: a review of 2604 cases. (3698975)
1986
25
Paralytic poliomyelitis and physiotherapy. (3765066)
1986
26
Paralytic poliomyelitis in children: some facts and figures from a hospital at Calcutta--1. (3835135)
1985
27
The problem of paralytic poliomyelitis in the urban and rural population around Lucknow, India. (701784)
1978
28
Paralytic poliomyelitis in children. (924651)
1977
29
Outbreak of type I paralytic poliomyelitis in Kampala City and the surrounding Mengo (East and West Buganda) Districts of Uganda during 1969. (4667457)
1972
30
Serum and urinary creatine and creatinine in paralytic poliomyelitis. (5121527)
1971
31
Paralytic poliomyelitis in a contact of a vaccinated child. (6023641)
1967
32
Paralytic poliomyelitis in a child with hypogammaglobulinemia: probable implication of type I vaccine strain. (5930025)
1966
33
Epidemiology of paralytic poliomyelitis. (5976571)
1966
34
Acupuncture in the treatment of paralytic poliomyelitis. (5873757)
1965
35
Paralytic poliomyelitis in Canada, 1960. (14460130)
1962
36
Preconceptions about vaccination against paralytic poliomyelitis. (13637560)
1959
37
Are-assessment of the risk of provoking paralytic poliomyelitis by making prophylactic inoculations against diphtheria and pertussis. (13664982)
1959
38
Paralytic Poliomyelitis in Canada, Week ending October 4, 1958. (20325819)
1958
39
Influence of prior active immunization on the presence of poliomyelitis virus in the pharynx and stools of family contacts of patients with paralytic poliomyelitis. (13542077)
1958
40
Glossopharyngeal breathing as an aid to recovery from paralytic poliomyelitis. (13313534)
1956
41
Progress in the control of paralytic poliomyelitis through vaccination. (13276873)
1955
42
Observations on the use of gamma globulin as a control measure in paralytic poliomyelitis in siblings; report of two cases. (13213643)
1954
43
The treatment of acute paralytic poliomyelitis. (13132157)
1954
44
Further investigation into the association between immunizing injections and paralytic poliomyelitis. (13188983)
1954
45
The present status of gamma globulin in the prevention of paralytic poliomyelitis. (13148180)
1954
46
The role of immunization procedures in the precipitation of paralytic poliomyelitis. (13019721)
1953
47
The prevention of paralytic poliomyelitis; recent research suggests cautious optimism. (13002806)
1952
48
Dual antibody response to coxsackie and poliomyelitis viruses in patients with paralytic poliomyelitis. (14781191)
1950
49
The diagnostic difficulties on non-paralytic poliomyelitis. (18132542)
1949
50
Non-paralytic poliomyelitis; some observations on differential diagnosis. (18124598)
1949

Genetic Variations for Paralytic Poliomyelitis

Expression for genes affiliated with Paralytic Poliomyelitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paralytic Poliomyelitis

Search GEO for disease gene expression data for Paralytic Poliomyelitis.

Pathways for genes affiliated with Paralytic Poliomyelitis

Sources:
30KEGG, 56SinoBiological, 53R&D Systems, 38NCBI BioSystems Database, 54Reactome
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Compounds for genes affiliated with Paralytic Poliomyelitis

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45Novoseek
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Compounds related to Paralytic Poliomyelitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ionomycin459.1CD40LG, BTK
2ivig458.8CD40LG, BTK

GO Terms for genes affiliated with Paralytic Poliomyelitis

Sources:
16Gene Ontology
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Biological processes related to Paralytic Poliomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:0507769.4CD40LG, PVR

Products for genes affiliated with Paralytic Poliomyelitis

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Sources for Paralytic Poliomyelitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet