MCID: PRL013
MIFTS: 28

Paralytic Poliomyelitis malady

Categories: Infectious diseases

Aliases & Classifications for Paralytic Poliomyelitis

Aliases & Descriptions for Paralytic Poliomyelitis:

Name: Paralytic Poliomyelitis 12 14
Poliomyelitis, Paralytic 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050515

Summaries for Paralytic Poliomyelitis

Disease Ontology : 12 A poliomyelitis that results_in destruction located in motor neurons of central nervous system, has material basis in Human poliovirus 1, has material basis in Human poliovirus 2, or has material basis in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has symptom loss of reflexes, has symptom muscle spasms, and has symptom acute flaccid paralysis.

MalaCards based summary : Paralytic Poliomyelitis, also known as poliomyelitis, paralytic, is related to poliomyelitis and spinal polio, and has symptoms including loss of reflexes, muscle spasms and acute flaccid paralysis. An important gene associated with Paralytic Poliomyelitis is PVR (Poliovirus Receptor), and among its related pathways/superpathways are G12-G13 in Cellular Signaling and Platelet activation. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include breast, spinal cord and bone.

Related Diseases for Paralytic Poliomyelitis

Diseases related to Paralytic Poliomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
id Related Disease Score Top Affiliating Genes
1 poliomyelitis 11.4
2 spinal polio 11.1
3 bulbospinal polio 11.1
4 bulbar polio 11.1
5 diphtheria 10.0
6 meningitis 10.0
7 pertussis 10.0
8 neurotic disorder 10.0 BTK PVR
9 tetanus 9.9
10 aseptic meningitis 9.9
11 agammaglobulinemia 9.9
12 respiratory failure 9.8
13 west nile virus 9.8
14 lateral sclerosis 9.8
15 leprosy 9.8
16 ataxia-telangiectasia 9.8
17 syringomyelia 9.8
18 common variable immunodeficiency 9.8
19 tuberculosis 9.8
20 severe combined immunodeficiency 9.8
21 spinal cord injury 9.8
22 mhc class ii deficiency 9.8
23 restless legs syndrome 9.8
24 myocarditis 9.8
25 osteomyelitis 9.8
26 hansen's disease 9.8
27 mumps 9.8
28 ataxia 9.8
29 spasticity 9.8
30 ross river fever 8.9 ARHGEF1 BTK NDUFAF3 NID1 PVR TDP2

Graphical network of the top 20 diseases related to Paralytic Poliomyelitis:



Diseases related to Paralytic Poliomyelitis

Symptoms & Phenotypes for Paralytic Poliomyelitis

Symptoms:

12
  • loss of reflexes
  • muscle spasms
  • acute flaccid paralysis

Drugs & Therapeutics for Paralytic Poliomyelitis

Drugs for Paralytic Poliomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 Polio End-game Strategies - Poliovirus Type 2 Challenge Study Completed NCT02189811 Phase 4
2 Randomized Controlled Trial for Immunogenicity and Safety Evaluation of Bivalent Types 1 and 3 Oral Poliovirus Vaccine Completed NCT02785705 Phase 3
3 Study of Mental Fatigue in Polio Survivors Unknown status NCT00487487

Search NIH Clinical Center for Paralytic Poliomyelitis

Genetic Tests for Paralytic Poliomyelitis

Anatomical Context for Paralytic Poliomyelitis

MalaCards organs/tissues related to Paralytic Poliomyelitis:

39
Breast, Spinal Cord, Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Paralytic Poliomyelitis:

18
Motor Neurons Of Central Nervous System

Publications for Paralytic Poliomyelitis

Articles related to Paralytic Poliomyelitis:

(show top 50) (show all 354)
id Title Authors Year
1
Vaccine Associated Paralytic Poliomyelitis Unmasking Common Variable Immunodeficiency. ( 28361789 )
2017
2
A cluster of paralytic poliomyelitis cases due to transmission of slightly diverged Sabin-2 vaccine virus. ( 27099315 )
2016
3
Vaccine associated paralytic poliomyelitis cases from children presenting with acute flaccid paralysis in Uganda. ( 26058454 )
2015
4
An unusual case of vaccine-associated paralytic poliomyelitis. ( 25285130 )
2014
5
Vaccine-associated paralytic poliomyelitis in the postelimination era in Latin America and the Caribbean, 1992-2011. ( 24520126 )
2014
6
Vaccine-associated paralytic poliomyelitis and BCG-osis in an immigrant child with severe combined immunodeficiency syndrome - Texas, 2013. ( 25144542 )
2014
7
Outbreaks of paralytic poliomyelitis during 1996-2012: the changing epidemiology of a disease in the final stages of eradication. ( 25316846 )
2014
8
Examination of motor unit control properties of the vastus lateralis in an individual that had acute paralytic poliomyelitis. ( 25083857 )
2014
9
Circadian variation of fatigue in paralytic poliomyelitis and postpolio syndrome: just fatigue or masked restless legs syndrome? ( 24964120 )
2014
10
Effectiveness of oral polio vaccination against paralytic poliomyelitis: a matched case-control study in somalia. ( 25316835 )
2014
11
Vaccine-associated paralytic poliomyelitis: a case report. ( 24647260 )
2014
12
Vaccine-associated paralytic poliomyelitis: a review of the epidemiology and estimation of the global burden. ( 25316859 )
2014
13
Combined immunodeficiency presenting with vaccine-associated paralytic poliomyelitis: a case report and narrative review of literature. ( 24294834 )
2013
14
Circadian variation of fatigue in both patients with paralytic poliomyelitis and post-polio syndrome. ( 23857622 )
2013
15
Children with paralytic poliomyelitis: utilization of physiotherapy services in Zamfara State, Nigeria. ( 22871225 )
2013
16
Apropos risks associated with the use of live-attenuated vaccine poliovirus strains and the strategies for control and eradication of paralytic poliomyelitis. ( 23249227 )
2012
17
Children with paralytic poliomyelitis: a cross-sectional study of knowledge, attitudes and beliefs of parents in Zamfara state, Nigeria. ( 23083466 )
2012
18
Vaccine-associated paralytic poliomyelitis in Japan. ( 22325660 )
2012
19
Risks associated with the use of live-attenuated vaccine poliovirus strains and the strategies for control and eradication of paralytic poliomyelitis. ( 22827246 )
2012
20
Paralytic poliomyelitis associated with Sabin monovalent and bivalent oral polio vaccines in Hungary. ( 21685412 )
2011
21
MRI findings in an infant with vaccine-associated paralytic poliomyelitis. ( 20440488 )
2010
22
MR finding in vaccine-associated paralytic poliomyelitis. ( 20567967 )
2010
23
A case of paralytic poliomyelitis associated with poliovirus vaccine strains in Hokkaido, Japan. ( 20495280 )
2010
24
Vaccine-associated paralytic poliomyelitis in a non-immunocompromised infant. ( 20880307 )
2010
25
Vaccine-associated paralytic poliomyelitis in an infant with perianal abscesses. ( 20449625 )
2010
26
Vaccine-associated paralytic poliomyelitis in immunodeficient children, Iran, 1995-2008. ( 20587188 )
2010
27
Molecular characterization of poliovirus isolates from children who contracted vaccine-associated paralytic poliomyelitis (VAPP) following administration of monovalent type 3 oral poliovirus vaccine in the 1960s in Hungary. ( 19863665 )
2010
28
Ala67Thr mutation in the poliovirus receptor CD155 is a potential risk factor for vaccine and wild-type paralytic poliomyelitis. ( 19319949 )
2009
29
Three cases of paralytic poliomyelitis associated with type 3 vaccine poliovirus strains in Bulgaria. ( 19626606 )
2009
30
Vaccine - associated paralytic poliomyelitis in a pre-vaccinated infant. ( 18626544 )
2008
31
Vaccine-associated paralytic poliomyelitis in a pre-vaccinated infant. ( 18998027 )
2008
32
Novel BTK mutation presenting with vaccine-associated paralytic poliomyelitis. ( 18317803 )
2008
33
Poisson-model analysis of the risk of vaccine-associated paralytic poliomyelitis in Japan between 1971 and 2000. ( 18362395 )
2008
34
Effectiveness of immunization against paralytic poliomyelitis in Nigeria. ( 18923171 )
2008
35
Paralytic poliomyelitis during the pre-, peri- and post-suspension periods of a polio immunization campaign. ( 18628551 )
2008
36
Vaccine-associated paralytic poliomyelitis: a case report of flaccid monoparesis after oral polio vaccine. ( 17449951 )
2007
37
Characterization of mutations in the VP(1) region of Sabin strain type 1 polioviruses isolated from vaccine-associated paralytic poliomyelitis cases in Iran. ( 17590391 )
2007
38
Vaccine-associated paralytic poliomyelitis in a patient with MHC class II deficiency. ( 17509935 )
2007
39
[Cellular and humoral immunodeficiency in children with vaccine-associated paralytic poliomyelitis]. ( 17297880 )
2006
40
Clinical presentations of acute paralytic poliomyelitis. ( 16386337 )
2006
41
Vaccine-associated paralytic poliomyelitis caused by contact infection. ( 16617188 )
2006
42
No evidence for prolonged excretion of polioviruses in persons with residual paralytic poliomyelitis in Ethiopia, Pakistan and Guatemala. ( 16682222 )
2006
43
Imported vaccine-associated paralytic poliomyelitis--United States, 2005. ( 16456525 )
2006
44
Strength and endurance of knee extensors in subjects after paralytic poliomyelitis. ( 16096231 )
2005
45
Incidence of adaptive equipment use in subjects with a remote history of paralytic poliomyelitis. ( 16186550 )
2005
46
Clinical presentations of acute paralytic poliomyelitis. ( 15970362 )
2005
47
A developing country perspective on vaccine-associated paralytic poliomyelitis. ( 15106301 )
2004
48
Framework for evaluating the risks of paralytic poliomyelitis after global interruption of wild poliovirus transmission. ( 15106299 )
2004
49
Electrodiagnostic features of acute paralytic poliomyelitis associated with West Nile virus infection. ( 14981736 )
2004
50
Persistence of vaccine-derived polioviruses among immunodeficient persons with vaccine-associated paralytic poliomyelitis. ( 14673763 )
2003

Variations for Paralytic Poliomyelitis

Expression for Paralytic Poliomyelitis

Search GEO for disease gene expression data for Paralytic Poliomyelitis.

Pathways for Paralytic Poliomyelitis

Pathways related to Paralytic Poliomyelitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.05 ARHGEF1 BTK
2 10.71 ARHGEF1 BTK

GO Terms for Paralytic Poliomyelitis

Sources for Paralytic Poliomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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