MCID: PRL014
MIFTS: 27

Paralytic Squint

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Paralytic Squint

MalaCards integrated aliases for Paralytic Squint:

Name: Paralytic Squint 12 14
Paralytic Strabismus 12 69
Incomitant Dissociation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10863
ICD10 32 H49 H49.9
ICD9CM 34 378.5 378.50
UMLS 69 C0152221

Summaries for Paralytic Squint

MalaCards based summary : Paralytic Squint, also known as paralytic strabismus, is related to kearns-sayre syndrome and strabismus. An important gene associated with Paralytic Squint is TUBB3 (Tubulin Beta 3 Class III), and among its related pathways/superpathways is Glypican 1 network. Affiliated tissues include eye.

Related Diseases for Paralytic Squint

Diseases related to Paralytic Squint via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 kearns-sayre syndrome 30.9 KIF21A PHOX2A TUBB3
2 strabismus 30.7 CHN1 KIF21A PHOX2A TUBB3
3 oculomotor nerve paralysis 30.4 CHN1 KANTR
4 tukel syndrome 30.4 CHN1 KIF21A PHOX2A TUBB2B TUBB3
5 fourth cranial nerve palsy 29.7 CHN1 HCK PRL PRNP
6 abducens nerve disease 10.6
7 tubulinopathy-associated dysgyria 10.5 TUBB2B TUBB3
8 fibrosis of extraocular muscles, congenital, 2 10.5 KIF21A PHOX2A
9 marcus gunn phenomenon 10.5 CHN1 TUBB3
10 ovarian carcinosarcoma 10.4 FUT2 TUBB3
11 neonatal anemia 10.4 TUBB2B TUBB3
12 congenital ptosis 10.4 CHN1 KIF21A TUBB3
13 deafness, autosomal dominant 28 10.4 CHN1 KIF21A TUBB3
14 moebius syndrome 10.4 PHOX2A TUBB3
15 ptosis 10.3 KIF21A PHOX2A TUBB3
16 alternating esotropia 10.3 CHN1 KANTR
17 esotropia 10.3 CHN1 TUBB3
18 exotropia 10.2 CHN1 KIF21A PHOX2A TUBB3
19 ocular motility disease 10.2 CHN1 KIF21A PHOX2A TUBB3
20 third cranial nerve disease 10.2 CHN1 KANTR
21 tolosa-hunt syndrome 10.2
22 duane retraction syndrome 10.2 CHN1 EPHA4 KIF21A TUBB3
23 pylorospasm 10.2 HCK KANTR
24 hyperhidrosis, gustatory 10.1 HCK KANTR
25 anismus 10.1 FUT2 KANTR
26 cerebellopontine angle meningioma 10.1 KANTR SAMHD1
27 auditory agnosia 10.1 KANTR PRNP
28 facial paralysis 10.1 CADM1 KANTR TUBB3
29 fourth cranial nerve palsy, familial congenital 10.1
30 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 1 10.1
31 gaze palsy, familial horizontal, with progressive scoliosis, 1 10.1
32 total third-nerve palsy 10.1
33 chronic progressive external ophthalmoplegia 10.1
34 trochlear nerve disease 10.1
35 autosomal dominant progressive external ophthalmoplegia 10.1
36 maternally-inherited progressive external ophthalmoplegia 10.1
37 congenital trochlear nerve palsy 10.1
38 anteroseptal myocardial infarction 10.1 FUT2 KANTR
39 tabes dorsalis 10.0 KANTR SH3BP5
40 peripheral nervous system disease 10.0 CHN1 KANTR KIF21A TUBB3
41 accommodative esotropia 10.0 CHN1 KANTR SAMHD1
42 dengue virus 10.0
43 dengue disease 10.0
44 nervous system disease 9.9 KANTR PRNP TUBB3
45 cranial nerve disease 9.9 CHN1 KANTR KIF21A PHOX2A TUBB3
46 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.8
47 keratopathy 9.8
48 thrombosis 9.8
49 lyme disease 9.8
50 blepharospasm 9.8

Graphical network of the top 20 diseases related to Paralytic Squint:



Diseases related to Paralytic Squint

Symptoms & Phenotypes for Paralytic Squint

Drugs & Therapeutics for Paralytic Squint

Search Clinical Trials , NIH Clinical Center for Paralytic Squint

Genetic Tests for Paralytic Squint

Anatomical Context for Paralytic Squint

MalaCards organs/tissues related to Paralytic Squint:

38
Eye

Publications for Paralytic Squint

Articles related to Paralytic Squint:

(show all 17)
# Title Authors Year
1
Paralytic strabismus and papilloedema caused by dural sinus thrombosis after bee sting. ( 25234425 )
2014
2
Acquired paralytic strabismus in Southern Taiwan. ( 23608076 )
2013
3
Paralytic strabismus in South African Black and mixed race children--a 15-year clinic-based review. ( 23171209 )
2012
4
Paralytic squint due to abducens nerve palsy: a rare consequence of dengue fever. ( 22799448 )
2012
5
Paralytic strabismus: third, fourth, and sixth nerve palsy. ( 20638001 )
2010
6
Five cases of paralytic strabismus as a rare feature of lyme disease. ( 19193112 )
2009
7
Filamentary keratopathy caused by corneal occlusion by large-angle paralytic strabismus. ( 17133065 )
2006
8
Botulinum toxin in the treatment of paralytic strabismus and essential blepharospasm. ( 8125543 )
1993
9
Paralytic squint treated with acupuncture. ( 6570146 )
1984
10
The use of prisms in paralytic squint. ( 900621 )
1977
11
A surgery on twenty six thousand and three hundred seventy eight patients with convergent squint (26378), thirteen thousand, one hundred and eighty one patients with divergent squint (13181), one thousand and twenty nine patients of vertical squint (1029), ten thousand and one hundred thirty nine patients of heterophoria (10139) and two thousand sixty one patients of paralytic squint (2061) seen during the past ten years at Giza Ophthalmic Hospital Squint Clinic from the year 1960 to the year 1970. ( 4666806 )
1972
12
Diagnosis of paralytic squint. ( 5154750 )
1971
13
NON-PARALYTIC squint. ( 13450382 )
1957
14
Paralytic squint. ( 20295367 )
1947
15
Clinical orthoptic procedure: paralytic squint. ( 20295365 )
1947
16
SOME CASES OF PARALYTIC SQUINT. ( 18169478 )
1937
17
Surgical Treatment of Non-Paralytic Squint. ( 29013305 )
1937

Variations for Paralytic Squint

Expression for Paralytic Squint

Search GEO for disease gene expression data for Paralytic Squint.

Pathways for Paralytic Squint

Pathways related to Paralytic Squint according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.04 HCK PRNP

GO Terms for Paralytic Squint

Cellular components related to Paralytic Squint according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 8.92 EPHA4 GABBR1 PRNP TUBB3

Biological processes related to Paralytic Squint according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to amyloid-beta GO:1904646 9.26 EPHA4 PRNP
2 regulation of axonogenesis GO:0050770 9.16 CHN1 EPHA4
3 motor neuron axon guidance GO:0008045 8.96 CHN1 EPHA4
4 negative regulation of long-term synaptic potentiation GO:1900272 8.62 EPHA4 PRNP

Molecular functions related to Paralytic Squint according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ephrin receptor binding GO:0046875 8.62 CHN1 EPHA4

Sources for Paralytic Squint

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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