MCID: PRN021
MIFTS: 47

Paranasal Sinus Disease malady

Respiratory diseases category
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Summaries for Paranasal Sinus Disease

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65Wikipedia, 33MalaCards
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Wikipedia:65 Paranasal sinuses are a group of four paired air-filled spaces that surround the nasal cavity (maxillary... more...

MalaCards: Paranasal Sinus Disease, also known as paranasal sinus disorder, is related to aspergillosis and bronchitis. An important gene associated with Paranasal Sinus Disease is IL17A (interleukin 17A), and among its related pathways are Th1 Differentiation and Th17 Differentiation. The compounds aa861 and notoginsenoside r1 have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and thyroid, and related mouse phenotypes are skeleton and digestive/alimentary.

Aliases & Classifications for Paranasal Sinus Disease

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8Disease Ontology, 62UMLS, 35MeSH, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

paranasal sinus disease 8
paranasal sinus disorder 8
paranasal sinus diseases 62
disorder of nasal sinus 8


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Disease Ontology8 DOID:1352
MeSH35 D010254
SNOMED-CT58 7393007
NCIt40 C26843

Related Diseases for Paranasal Sinus Disease

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17GeneCards, 18GeneDecks
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Diseases related to Paranasal Sinus Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1aspergillosis30.3IFNG
2bronchitis30.3ALOX5, IL17A
3cystic fibrosis10.3
4bronchiectasis10.1
5bell's palsy10.1
6eye disease10.1
7plasmacytoma10.1
8thyroiditis10.1
9headache10.1
10blindness10.1
11pleurisy10.1ALOX5
12malaria10.1IFNG
13eosinophilic fasciitis10.1IL5
14eosinophilia-myalgia syndrome10.1IL5
15strongyloidiasis10.1IL5
16encephalitis10.1IL17A
17bronchiolitis10.1IL5
18carotid artery thrombosis10.1SERPINE1
19ureter cancer10.1PLAU, PLAUR
20paroxysmal nocturnal hemoglobinuria10.1PLAU, PLAUR
21pemphigus10.1PLAUR, PLAU
22pneumonia10.1IL5, IL17A
23allergic contact dermatitis10.0IL17A, IL5
24hepatitis b10.0IFNG, IL17A
25pemphigus vulgaris10.0PLAU, PLAUR
26allergic rhinitis10.0ALOX5, IL5
27angioedema10.0IL5, ALOX5
28uveitis10.0IL17A, IFNG
29sinusitis10.0IL5, ALOX5
30cutaneous leishmaniasis10.0IFNG, IL5
31anaplastic astrocytoma10.0PLAU, PLAUR
32sezary's disease10.0IFNG, IL5
33idiopathic pulmonary fibrosis10.0IFNG, ALOX5
34leishmaniasis10.0IFNG, IL5
35schistosomiasis10.0IL5, IFNG
36cutaneous t cell lymphoma10.0IFNG, IL5
37encephalomyelitis10.0IL17A, ALOX5, IFNG
38severe combined immunodeficiency10.0IL5, IFNG
39ulcerative colitis10.0IL17A, ALOX5, IFNG
40inflammatory bowel disease10.0IFNG, IL17A, ALOX5
41oral cancer10.0PLAU, PLAUR, ALOX5
42glioblastoma multiforme10.0PLAUR, PLAU, ALOX5
43systemic lupus erythematosus10.0IL17A, ALOX5, IFNG
44atopy10.0IL5, IFNG
45brain cancer10.0PLAU, PLAUR, ALOX5
46arthritis10.0IFNG, IL17A, ALOX5
47colorectal cancer10.0ALOX5, PLAU, PLAUR
48atopic dermatitis10.0IL5, IFNG, IL17A
49tetanus10.0IFNG, IL5
50skin disease10.0IL5, IFNG, IL17A

Graphical network of the top 20 diseases related to Paranasal Sinus Disease:



Diseases related to paranasal sinus disease

Symptoms for Paranasal Sinus Disease

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Drugs & Therapeutics for Paranasal Sinus Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Paranasal Sinus Disease

Search NIH Clinical Center for Paranasal Sinus Disease

Genetic Tests for Paranasal Sinus Disease

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Anatomical Context for Paranasal Sinus Disease

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33MalaCards
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MalaCards organs/tissues related to Paranasal Sinus Disease:

33
Eye, Bone, Thyroid, T cells

Animal Models for Paranasal Sinus Disease or affiliated genes

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37MGI
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Publications for Paranasal Sinus Disease

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52PubMed
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Articles related to Paranasal Sinus Disease:

(show all 43)
idTitleAuthorsYear
1
A stereological study on the correlation of inferior turbinate hypertrophy and paranasal sinus disease. (24389985)
2014
2
The impact of a patient's age on the clinical presentation of inflammatory paranasal sinus disease. (23702318)
2013
3
Prognosis for sixth nerve palsy arising from paranasal sinus disease. (24119609)
2013
4
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): treatments and long-term results of treatments. (21812808)
2012
5
Ophthalmic manifestations of paranasal sinus disease: a clinical grading system. (22411699)
2012
6
Clinical consensus statement: appropriate use of computed tomography for paranasal sinus disease. (23054429)
2012
7
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): ancillary diagnostic findings and involvement of the various sinus compartments. (21812807)
2012
8
Paranasal sinus disease in horses. (21870345)
2011
9
Complications of nose and paranasal sinus disease. (23272436)
2011
10
The expression of fibrinolytic components in chronic paranasal sinus disease. (21711960)
2011
11
Thyroid Eye Disease and Paranasal Sinus Disease. (20924307)
2010
12
T-cell regulation in chronic paranasal sinus disease. (18423831)
2008
13
Significance of blood-tinged post-nasal drip in paranasal sinus disease. (17888198)
2008
14
The incidence of concha bullosa and its relationship to nasal septal deviation and paranasal sinus disease. (15502150)
2004
15
Headaches due to nasal and paranasal sinus disease. (15062525)
2004
16
The role of leukotriene inhibitors in patients with paranasal sinus disease. (12923360)
2003
17
CT characterization of inflammatory paranasal sinus disease in cystic fibrosis. (11972457)
2002
18
Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. (11195032)
2000
19
Use of standard radiography to diagnose paranasal sinus disease of asthmatic children in Taiwan: comparison with computed tomography. (10466541)
1999
20
Optic nerve blindness due to paranasal sinus disease. (10420111)
1999
21
Cytokines and chemokines in paranasal sinus diseases]. (10535064)
1999
22
Relative value of MR imaging as compared with CT in the diagnosis of inflammatory paranasal sinus disease. (9885603)
1999
23
Imaging of paranasal sinus disease. (9168874)
1997
24
Imaging in paranasal sinus disease. (9619203)
1997
25
Correlation of clinical examination with computer tomography in paranasal sinus disease. (9209590)
1997
26
Malignant plasmacytoma appearing as invasive paranasal sinus disease after cardiac transplantation. (8883660)
1996
27
Paranasal sinus disease in patients with cystic fibrosis. (8834282)
1996
28
Efficacy of systemic corticosteroid treatment for anosmia with nasal and paranasal sinus disease. (8560170)
1995
29
Nasal and paranasal sinus disease in patients with congenital velopharyngeal insufficiency. (8049050)
1994
30
Effect of a topical vasoconstrictor on computed tomography of paranasal sinus disease. (8421421)
1993
31
Endoscopic examination and treatment of paranasal sinus disease in 16 horses. (8116208)
1993
32
Inflammatory paranasal sinus disease in Bell's palsy demonstrated by magnetic resonance imaging. (8372929)
1993
33
Paranasal sinus disease in HIV antibody positive patients. (8335314)
1993
34
The prevalence of paranasal sinus disease in HIV infection and AIDS on cranial MR imaging. (8472478)
1993
35
Limited-slice CT in the evaluation of paranasal sinus disease in children. (1898816)
1991
36
Paranasal sinus disease with intracranial extension: aspergillosis versus malignancy. (3131605)
1988
37
Computed tomography in nasal and paranasal sinus disease. (6482629)
1984
38
Comparison between transillumination and the roentgenogram in diagnosing paranasal sinus disease. (7451769)
1981
39
Enzyme therapy in the triad of paranasal sinus disease, allergic asthmatic bronchitis, and bronchiectasis. (14446650)
1959
40
The changing years: their impact upon the management of paranasal sinus disease. (13647565)
1958
41
The changing years: their impact upon the management of paranasal sinus disease. (13583895)
1958
42
Chronic paranasal sinus disease in adults; factors influencing treatment. (18124358)
1949
43
Modern trends in diagnosis and treatment of paranasal sinus disease with particular reference to allergic manifestations. (20261616)
1947

Variations for Paranasal Sinus Disease

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Expression for genes affiliated with Paranasal Sinus Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paranasal Sinus Disease

Search GEO for disease gene expression data for Paranasal Sinus Disease.

Pathways for genes affiliated with Paranasal Sinus Disease

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Sources:
50PathCards, 54R&D Systems, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 5Cell Signaling Technology, 55Reactome, 60Thomson Reuters, 12EMD Millipore
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Pathways related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL27-mediated signaling events38
9.6IFNG, IL17A
2
Show member pathways
9.6IFNG, IL17A
39.6IL17A, IFNG
49.5PLAU, PLAUR
59.5PLAU, PLAUR
69.5PLAUR, PLAU
79.4ALOX5, IL5
89.4IFNG, PLAU
9
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.3IFNG, IL5
109.3IFNG, IL5
119.3IFNG, IL5
129.3IL5, IFNG
139.3IL5, IFNG
149.3IL5, IFNG
159.2PLAUR, SERPINE1
169.1PLAU, SERPINE1
17
Show member pathways
9.1SERPINE1, PLAU
189.1SERPINE1, IFNG
199.0IL5, SERPINE1
20
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.0IL17A, IL5, IFNG
21
Show member pathways
thioredoxin pathway38
8.7ALOX5, IFNG, SERPINE1
22
Show member pathways
8.7SERPINE1, PLAUR, PLAU
23
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.7PLAU, PLAUR, SERPINE1
24
Show member pathways
8.7PLAU, PLAUR, SERPINE1
258.7PLAU, PLAUR, SERPINE1
26
Show member pathways
8.7PLAU, PLAUR, SERPINE1
27
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
8.7SERPINE1, PLAUR, PLAU
288.6SERPINE1, IFNG, PLAU
29
Show member pathways
8.5ALOX5, IL17A, IL5, IFNG
30
Show member pathways
8.5ALOX5, IL17A, IL5, IFNG

Compounds for genes affiliated with Paranasal Sinus Disease

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Sources:
45Novoseek, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 51PharmGKB, 3BitterDB
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Compounds related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1aa861459.4ALOX5, IL5
2notoginsenoside r1459.4PLAU, SERPINE1
35-oxoete459.4ALOX5, PLAUR, IL5
4saporin459.4PLAUR, PLAU
5nickel45 2410.4IL5, PLAUR, IL17A
6nickel subsulfide459.3PLAU, SERPINE1
7n-formylmethionyl-leucylphenylalanine459.3IL5, ALOX5, PLAUR
8rolipram45 61 2911.3IFNG, IL5, ALOX5
9glucosamine45 24 1111.2PLAUR, IL5, IFNG
10curcumin459.1PLAU, IL17A, ALOX5, PLAUR
11eaca459.1PLAUR, SERPINE1, PLAU
12p-amino benzamidine459.1PLAU, PLAUR, SERPINE1
13tranexamic acid45 1110.1PLAU, PLAUR, SERPINE1
14epsilon aminocaproic acid459.1PLAUR, SERPINE1, PLAU
15diisopropylfluorophosphate459.1SERPINE1, PLAU, PLAUR
16cerivastatin51 45 29 1112.0SERPINE1, PLAU, PLAUR
17hirudin459.0PLAU, SERPINE1, PLAUR
18calcitriol45 61 24 1112.0IFNG, ALOX5, PLAU, PLAUR
19kininogen458.9PLAU, PLAUR, SERPINE1
20hydrocortisone45 3 61 1111.9PLAU, IL5, IFNG
21sp 60012545 619.9IL17A, SERPINE1, PLAU
22dmso458.9PLAUR, PLAU, ALOX5, IL5
23aprotinin45 119.9PLAUR, SERPINE1, PLAU
2415-deoxy-delta-12,14-prostaglandin j2458.8PLAU, IFNG, SERPINE1
25histamine45 29 2410.7ALOX5, PLAU, IL5, IFNG
26endotoxin458.7IL17A, IFNG, PLAUR, SERPINE1
27butyrate458.7IFNG, PLAU, PLAUR, IL5
28tgf beta1458.7PLAUR, PLAU, SERPINE1
29thapsigargin45 619.7PLAU, PLAUR, ALOX5, SERPINE1
30aspirin45 51 29 2411.6PLAU, SERPINE1, ALOX5, PLAUR
31pd 98,059458.6IL17A, SERPINE1, PLAUR, PLAU
32vitamin d458.5IL5, PLAUR, ALOX5, SERPINE1
33creatinine458.5PLAU, PLAUR, SERPINE1, IL17A
34thymidine45 249.4IL17A, PLAUR, IFNG, PLAU, IL5
35ly294002458.4IL5, SERPINE1, IL17A, PLAU
36herbimycin a45 619.4IL5, PLAUR, ALOX5, IFNG, PLAU
37arginine458.3PLAU, ALOX5, IL5, PLAUR, IFNG
38actinomycin d458.2PLAUR, SERPINE1, PLAU, IFNG, IL17A
39estrogen458.2ALOX5, PLAU, PLAUR, IL17A, SERPINE1
40h2o2458.2ALOX5, PLAU, PLAUR, IL5
41tacrolimus45 51 1110.2ALOX5, IL17A, IL5, IFNG, SERPINE1
42heparin45 29 24 1111.1IL5, ALOX5, SERPINE1, PLAUR, PLAU
43indomethacin45 29 61 1111.0PLAU, IFNG, PLAUR, IL17A, ALOX5, IL5
44pge2458.0ALOX5, IFNG, IL5, IL17A, PLAUR, PLAU
45retinoic acid45 248.8PLAU, SERPINE1, IFNG, PLAUR, IL5
46dexamethasone45 51 29 1110.7SERPINE1, IFNG, IL5, IL17A, PLAUR, ALOX5
47genistein45 29 61 3 24 1112.6ALOX5, PLAUR, IFNG, SERPINE1, PLAU, IL5
48cycloheximide457.6SERPINE1, ALOX5, IFNG, IL5, PLAUR, PLAU
49sb 20358045 618.2IL5, ALOX5, PLAU, PLAUR, IL17A, IFNG
50vegf457.2ALOX5, PLAU, PLAUR, IL17A, SERPINE1, IL5

GO Terms for genes affiliated with Paranasal Sinus Disease

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16Gene Ontology
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Cellular components related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5PLAU, PLAUR, IL5, IFNG, SERPINE1
2extracellular spaceGO:0056156.9ALOX5, SERPINE1, IFNG, IL5, IL17A, PLAU

Biological processes related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-23 productionGO:0327479.7IL17A, IFNG
2positive regulation of osteoclast differentiationGO:0456729.6IFNG, IL17A
3cellular component movementGO:0069289.5PLAUR, IFNG
4regulation of receptor activityGO:0104699.2PLAU, SERPINE1
5cellular response to lipopolysaccharideGO:0712228.8IFNG, SERPINE1
6fibrinolysisGO:0427308.8PLAU, PLAUR, SERPINE1
7blood coagulationGO:0075968.6PLAU, PLAUR, SERPINE1

Molecular functions related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL17A, IL5, IFNG

Products for genes affiliated with Paranasal Sinus Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Paranasal Sinus Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet