MCID: PRN021
MIFTS: 48

Paranasal Sinus Disease malady

Respiratory diseases category
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Summaries for Paranasal Sinus Disease

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Wikipedia:65 Paranasal sinuses are a group of four paired air-filled spaces that surround the nasal cavity (maxillary... more...

MalaCards based summary: Paranasal Sinus Disease, also known as disorder of nasal sinus, is related to aspergillosis and eosinophilia. An important gene associated with Paranasal Sinus Disease is IL17A (interleukin 17A), and among its related pathways are Th1 Differentiation and Th17 Differentiation. The compounds aa861 and notoginsenoside r1 have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and thyroid, and related mouse phenotypes are skeleton and digestive/alimentary.

Aliases & Classifications for Paranasal Sinus Disease

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Paranasal Sinus Disease, Aliases & Descriptions:

Name: Paranasal Sinus Disease 8
Disorder of Nasal Sinus 8 62
 
Paranasal Sinus Disorder 8
Paranasal Sinus Diseases 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:1352
NCIt39 C26843
SNOMED-CT57 7393007
MeSH34 D010254

Related Diseases for Paranasal Sinus Disease

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Diseases related to Paranasal Sinus Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1aspergillosis30.8IFNG
2eosinophilia30.2IFNG, IL5, ALOX5
3asthma29.7ALOX5, PLAUR, IL17A, IL5, IFNG
4pleurisy10.5ALOX5
5malaria10.4IFNG
6eosinophilic fasciitis10.4IL5
7eosinophilia-myalgia syndrome10.4IL5
8strongyloidiasis10.4IL5
9encephalitis10.4IL17A
10bronchiolitis10.4IL5
11carotid artery thrombosis10.3SERPINE1
12cystic fibrosis10.3
13headache10.3
14non-suppurative otitis media10.3ALOX5, IL17A
15ureter cancer10.2PLAUR, PLAU
16demyelinating disease10.2IL17A, IFNG
17paroxysmal nocturnal hemoglobinuria, somatic10.2PLAU, PLAUR
18pemphigus10.2PLAUR, PLAU
19pneumonia10.2IL17A, IL5
20allergic contact dermatitis10.2IL17A, IL5
21hepatitis b10.2IL17A, IFNG
22pemphigus vulgaris10.2PLAU, PLAUR
23allergic rhinitis10.2IL5, ALOX5
24uveitis10.2IFNG, IL17A
25angioedema10.2ALOX5, IL5
26sinusitis10.2ALOX5, IL5
27cutaneous leishmaniasis10.2IFNG, IL5
28grade iii astrocytoma10.1PLAUR, PLAU
29sezary's disease10.1IFNG, IL5
30bronchitis10.1
31bronchiectasis10.1
32bell's palsy10.1
33eye disease10.1
34plasmacytoma10.1
35thyroiditis10.1
36blindness10.1
37idiopathic pulmonary fibrosis10.1ALOX5, IFNG
38leishmaniasis10.1IL5, IFNG
39schistosomiasis10.1IL5, IFNG
40cutaneous t cell lymphoma10.1IL5, IFNG
41colitis10.1ALOX5, IL17A, IFNG
42severe combined immunodeficiency10.1IL5, IFNG
43ulcerative colitis10.1ALOX5, IL17A, IFNG
44inflammatory bowel disease10.1ALOX5, IL17A, IFNG
45oral cancer10.1ALOX5, PLAU, PLAUR
46glioblastoma multiforme10.1PLAUR, PLAU, ALOX5
47systemic lupus erythematosus10.1IFNG, IL17A, ALOX5
48atopy10.1IL5, IFNG
49brain cancer10.0PLAUR, PLAU, ALOX5
50arthritis10.0ALOX5, IL17A, IFNG

Graphical network of the top 20 diseases related to Paranasal Sinus Disease:



Diseases related to paranasal sinus disease

Symptoms for Paranasal Sinus Disease

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Drugs & Therapeutics for Paranasal Sinus Disease

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Drug clinical trials:

Search ClinicalTrials for Paranasal Sinus Disease

Search NIH Clinical Center for Paranasal Sinus Disease

Genetic Tests for Paranasal Sinus Disease

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Anatomical Context for Paranasal Sinus Disease

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MalaCards organs/tissues related to Paranasal Sinus Disease:

32
Eye, Bone, Thyroid, T cells

Animal Models for Paranasal Sinus Disease or affiliated genes

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Publications for Paranasal Sinus Disease

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Articles related to Paranasal Sinus Disease:

(show all 44)
idTitleAuthorsYear
1
Headaches caused by nasal and paranasal sinus disease. (24703542)
2014
2
A stereological study on the correlation of inferior turbinate hypertrophy and paranasal sinus disease. (24389985)
2014
3
The impact of a patient's age on the clinical presentation of inflammatory paranasal sinus disease. (23702318)
2013
4
Prognosis for sixth nerve palsy arising from paranasal sinus disease. (24119609)
2013
5
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): treatments and long-term results of treatments. (21812808)
2012
6
Ophthalmic manifestations of paranasal sinus disease: a clinical grading system. (22411699)
2012
7
Clinical consensus statement: appropriate use of computed tomography for paranasal sinus disease. (23054429)
2012
8
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): ancillary diagnostic findings and involvement of the various sinus compartments. (21812807)
2012
9
Paranasal sinus disease in horses. (21870345)
2011
10
Complications of nose and paranasal sinus disease. (23272436)
2011
11
The expression of fibrinolytic components in chronic paranasal sinus disease. (21711960)
2011
12
Thyroid Eye Disease and Paranasal Sinus Disease. (20924307)
2010
13
Paranasal sinus disease and sputum eosinophilia in prednisone-dependent asthma. (21144367)
2010
14
T-cell regulation in chronic paranasal sinus disease. (18423831)
2008
15
Significance of blood-tinged post-nasal drip in paranasal sinus disease. (17888198)
2008
16
The incidence of concha bullosa and its relationship to nasal septal deviation and paranasal sinus disease. (15502150)
2004
17
Headaches due to nasal and paranasal sinus disease. (15062525)
2004
18
The role of leukotriene inhibitors in patients with paranasal sinus disease. (12923360)
2003
19
CT characterization of inflammatory paranasal sinus disease in cystic fibrosis. (11972457)
2002
20
Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. (11195032)
2000
21
Optic nerve blindness due to paranasal sinus disease. (10420111)
1999
22
Cytokines and chemokines in paranasal sinus diseases]. (10535064)
1999
23
Relative value of MR imaging as compared with CT in the diagnosis of inflammatory paranasal sinus disease. (9885603)
1999
24
Imaging of paranasal sinus disease. (9168874)
1997
25
Imaging in paranasal sinus disease. (9619203)
1997
26
Correlation of clinical examination with computer tomography in paranasal sinus disease. (9209590)
1997
27
Malignant plasmacytoma appearing as invasive paranasal sinus disease after cardiac transplantation. (8883660)
1996
28
Paranasal sinus disease in patients with cystic fibrosis. (8834282)
1996
29
Efficacy of systemic corticosteroid treatment for anosmia with nasal and paranasal sinus disease. (8560170)
1995
30
Nasal and paranasal sinus disease in patients with congenital velopharyngeal insufficiency. (8049050)
1994
31
Effect of a topical vasoconstrictor on computed tomography of paranasal sinus disease. (8421421)
1993
32
Endoscopic examination and treatment of paranasal sinus disease in 16 horses. (8116208)
1993
33
Inflammatory paranasal sinus disease in Bell's palsy demonstrated by magnetic resonance imaging. (8372929)
1993
34
Paranasal sinus disease in HIV antibody positive patients. (8335314)
1993
35
The prevalence of paranasal sinus disease in HIV infection and AIDS on cranial MR imaging. (8472478)
1993
36
Limited-slice CT in the evaluation of paranasal sinus disease in children. (1898816)
1991
37
Paranasal sinus disease with intracranial extension: aspergillosis versus malignancy. (3131605)
1988
38
Computed tomography in nasal and paranasal sinus disease. (6482629)
1984
39
Comparison between transillumination and the roentgenogram in diagnosing paranasal sinus disease. (7451769)
1981
40
Enzyme therapy in the triad of paranasal sinus disease, allergic asthmatic bronchitis, and bronchiectasis. (14446650)
1959
41
The changing years: their impact upon the management of paranasal sinus disease. (13647565)
1958
42
The changing years: their impact upon the management of paranasal sinus disease. (13583895)
1958
43
Chronic paranasal sinus disease in adults; factors influencing treatment. (18124358)
1949
44
Modern trends in diagnosis and treatment of paranasal sinus disease with particular reference to allergic manifestations. (20261616)
1947

Variations for Paranasal Sinus Disease

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Expression for genes affiliated with Paranasal Sinus Disease

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Expression patterns in normal tissues for genes affiliated with Paranasal Sinus Disease

Search GEO for disease gene expression data for Paranasal Sinus Disease.

Pathways for genes affiliated with Paranasal Sinus Disease

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Pathways related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL27-mediated signaling events37
9.6IFNG, IL17A
2
Show member pathways
9.6IFNG, IL17A
39.6IL17A, IFNG
49.5PLAU, PLAUR
59.5PLAU, PLAUR
69.5PLAUR, PLAU
79.4ALOX5, IL5
89.4IFNG, PLAU
9
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.3IFNG, IL5
109.3IFNG, IL5
119.3IFNG, IL5
129.3IL5, IFNG
139.3IL5, IFNG
149.3IL5, IFNG
159.2PLAUR, SERPINE1
169.1PLAU, SERPINE1
17
Show member pathways
9.1SERPINE1, PLAU
189.1SERPINE1, IFNG
199.0IL5, SERPINE1
20
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.0IL17A, IL5, IFNG
21
Show member pathways
thioredoxin pathway37
8.7ALOX5, IFNG, SERPINE1
22
Show member pathways
8.7SERPINE1, PLAUR, PLAU
23
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.7PLAU, PLAUR, SERPINE1
24
Show member pathways
8.7PLAU, PLAUR, SERPINE1
258.7PLAU, PLAUR, SERPINE1
26
Show member pathways
8.7PLAU, PLAUR, SERPINE1
27
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.7SERPINE1, PLAUR, PLAU
288.6SERPINE1, IFNG, PLAU
29
Show member pathways
8.5ALOX5, IL17A, IL5, IFNG
30
Show member pathways
8.5ALOX5, IL17A, IL5, IFNG

Compounds for genes affiliated with Paranasal Sinus Disease

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Compounds related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1aa861449.4IL5, ALOX5
2notoginsenoside r1449.4PLAU, SERPINE1
35-oxoete449.4ALOX5, PLAUR, IL5
4saporin449.4PLAU, PLAUR
5nickel44 2410.4PLAUR, IL17A, IL5
6nickel subsulfide449.3PLAU, SERPINE1
7n-formylmethionyl-leucylphenylalanine449.3ALOX5, PLAUR, IL5
8rolipram44 61 2811.3IFNG, IL5, ALOX5
9glucosamine44 24 1111.2PLAUR, IL5, IFNG
10curcumin449.1ALOX5, PLAU, PLAUR, IL17A
11eaca449.1SERPINE1, PLAUR, PLAU
12p-amino benzamidine449.1PLAU, PLAUR, SERPINE1
13tranexamic acid44 1110.1SERPINE1, PLAUR, PLAU
14epsilon aminocaproic acid449.1PLAU, PLAUR, SERPINE1
15diisopropylfluorophosphate449.1PLAU, PLAUR, SERPINE1
16cerivastatin50 44 28 1112.0SERPINE1, PLAUR, PLAU
17hirudin449.0SERPINE1, PLAUR, PLAU
18calcitriol44 61 24 1112.0IFNG, PLAUR, PLAU, ALOX5
19kininogen448.9PLAU, PLAUR, SERPINE1
20hydrocortisone44 2 61 1111.9PLAU, IL5, IFNG
21sp 60012544 619.9SERPINE1, IL17A, PLAU
22dmso448.9IL5, PLAUR, PLAU, ALOX5
23aprotinin44 119.9SERPINE1, PLAUR, PLAU
2415-deoxy-delta-12,14-prostaglandin j2448.8SERPINE1, IFNG, PLAU
25histamine44 28 2410.7IFNG, IL5, PLAU, ALOX5
26endotoxin448.7SERPINE1, IFNG, IL17A, PLAUR
27butyrate448.7PLAU, PLAUR, IL5, IFNG
28tgf beta1448.7PLAU, PLAUR, SERPINE1
29thapsigargin44 619.7SERPINE1, PLAUR, PLAU, ALOX5
30aspirin44 50 28 2411.6SERPINE1, PLAUR, PLAU, ALOX5
31pd 98,059448.6PLAU, PLAUR, IL17A, SERPINE1
32vitamin d448.5SERPINE1, IL5, PLAUR, ALOX5
33creatinine448.5PLAU, PLAUR, IL17A, SERPINE1
34thymidine44 249.4IFNG, IL5, IL17A, PLAUR, PLAU
35ly294002448.4SERPINE1, IL5, IL17A, PLAU
36herbimycin a44 619.4IFNG, IL5, PLAUR, PLAU, ALOX5
37arginine448.3IFNG, IL5, PLAUR, PLAU, ALOX5
38actinomycin d448.2SERPINE1, IFNG, IL17A, PLAUR, PLAU
39estrogen448.2SERPINE1, IL17A, PLAUR, PLAU, ALOX5
40h2o2448.2IL5, PLAUR, PLAU, ALOX5
41tacrolimus44 50 1110.2SERPINE1, IFNG, IL5, IL17A, ALOX5
42heparin44 28 24 1111.1SERPINE1, IL5, PLAUR, PLAU, ALOX5
43indomethacin44 28 61 1111.0IFNG, IL5, IL17A, PLAUR, PLAU, ALOX5
44pge2448.0IFNG, IL5, IL17A, PLAUR, PLAU, ALOX5
45retinoic acid44 248.8SERPINE1, IFNG, IL5, PLAUR, PLAU
46dexamethasone44 50 28 1110.7SERPINE1, IFNG, IL5, IL17A, PLAUR, ALOX5
47genistein44 28 61 2 24 1112.6SERPINE1, IFNG, IL5, PLAUR, PLAU, ALOX5
48cycloheximide447.6SERPINE1, IFNG, IL5, PLAUR, PLAU, ALOX5
49sb 20358044 618.2ALOX5, SERPINE1, IFNG, IL5, IL17A, PLAUR
50vegf447.2SERPINE1, IFNG, IL5, IL17A, PLAUR, PLAU

GO Terms for genes affiliated with Paranasal Sinus Disease

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Cellular components related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5PLAU, PLAUR, IL5, IFNG, SERPINE1
2extracellular spaceGO:0056156.9ALOX5, SERPINE1, IFNG, IL5, IL17A, PLAU

Biological processes related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-23 productionGO:0327479.7IL17A, IFNG
2positive regulation of osteoclast differentiationGO:0456729.6IFNG, IL17A
3cellular component movementGO:0069289.5PLAUR, IFNG
4regulation of receptor activityGO:0104699.2PLAU, SERPINE1
5cellular response to lipopolysaccharideGO:0712228.8IFNG, SERPINE1
6fibrinolysisGO:0427308.8PLAU, PLAUR, SERPINE1
7blood coagulationGO:0075968.6PLAU, PLAUR, SERPINE1

Molecular functions related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL17A, IL5, IFNG

Products for genes affiliated with Paranasal Sinus Disease

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Sources for Paranasal Sinus Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet