MCID: PRN021
MIFTS: 45

Paranasal Sinus Disease malady

Summaries for Paranasal Sinus Disease

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63Wikipedia, 32MalaCards
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Wikipedia:63 Paranasal sinuses are a group of four paired air-filled spaces that surround the nasal cavity (maxillary... more...

MalaCards: Paranasal Sinus Disease, also known as paranasal sinus disorder, is related to cystic fibrosis and aspergillosis. An important gene associated with Paranasal Sinus Disease is IL17A (interleukin 17A), and among its related pathways are Senescence and Autophagy and PEDF Induced Signaling. The compounds pge2 and nickel have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and thyroid, and related mouse phenotypes are respiratory system and tumorigenesis.

Aliases & Classifications for Paranasal Sinus Disease

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

paranasal sinus disease 8
paranasal sinus disorder 8
paranasal sinus diseases 60
disorder of nasal sinus 8


External Ids:

Disease Ontology8 DOID:1352
NCIt39 C26843
SNOMED-CT56 7393007
MeSH34 D010254

Related Diseases for Paranasal Sinus Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Paranasal Sinus Disease:



Diseases related to paranasal sinus disease

Clinical Features for Paranasal Sinus Disease

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Drugs & Therapeutics for Paranasal Sinus Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Paranasal Sinus Disease

Drug clinical trials:

Search ClinicalTrials for Paranasal Sinus Disease

Search NIH Clinical Center for Paranasal Sinus Disease

Search CenterWatch for Paranasal Sinus Disease

Genetic Tests for Paranasal Sinus Disease

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Anatomical Context for Paranasal Sinus Disease

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32MalaCards
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MalaCards organs/tissues related to Paranasal Sinus Disease:

32
Eye, Bone, Thyroid, T cells

Animal Models for Paranasal Sinus Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Paranasal Sinus Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.7PLAUR, PLAU
2MP:00020069.2IL5, IFNG
3MP:00053818.3PLAU, IL17A, IL5, IFNG
4MP:00053768.2ALOX5, SERPINE1, IL5, IFNG
5MP:00053677.9IFNG, IL17A, PLAUR, SERPINE1
6MP:00053707.7IFNG, IL5, PLAU, PLAUR, SERPINE1
7MP:00053857.5IFNG, PLAU, PLAUR, SERPINE1, ALOX5
8MP:00053976.9ALOX5, IFNG, IL5, IL17A, PLAU, PLAUR
9MP:00053876.9IFNG, IL5, IL17A, PLAU, PLAUR, SERPINE1

Publications for Paranasal Sinus Disease

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50PubMed
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Articles related to Paranasal Sinus Disease:

(show all 49)
idTitleAuthorsYear
1
A stereological study on the correlation of inferior turbinate hypertrophy and paranasal sinus disease. (24389985)
2014
2
The impact of a patient's age on the clinical presentation of inflammatory paranasal sinus disease. (23702318)
2013
3
Immunoglobulin G4-related sclerosing disease of the paranasal sinus. (23047661)
2013
4
Prognosis for sixth nerve palsy arising from paranasal sinus disease. (24119609)
2013
5
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): treatments and long-term results of treatments. (21812808)
2012
6
Ophthalmic manifestations of paranasal sinus disease: a clinical grading system. (22411699)
2012
7
Clinical consensus statement: appropriate use of computed tomography for paranasal sinus disease. (23054429)
2012
8
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): ancillary diagnostic findings and involvement of the various sinus compartments. (21812807)
2012
9
Ophthalmic complications following treatment of paranasal sinus rhabdomyosarcoma in comparison to orbital disease. (21242849)
2011
10
Paranasal sinus disease in horses. (21870345)
2011
11
Complications of nose and paranasal sinus disease. (23272436)
2011
12
The expression of fibrinolytic components in chronic paranasal sinus disease. (21711960)
2011
13
Thyroid Eye Disease and Paranasal Sinus Disease. (20924307)
2010
14
Paranasal sinus disease and sputum eosinophilia in prednisone-dependent asthma. (21144367)
2010
15
T-cell regulation in chronic paranasal sinus disease. (18423831)
2008
16
Significance of blood-tinged post-nasal drip in paranasal sinus disease. (17888198)
2008
17
Total IgE levels and peripheral eosinophilia: correlation with mucosal disease based on computed tomographic imaging of the paranasal sinus. (17638784)
2007
18
Nasal and paranasal sinus manifestation of Rosai-Dorfman disease. (16218519)
2005
19
Extranodal Rosai-Dorfman disease of bone, subcutaneous tissue and paranasal sinus mucosa with a review of its pathogenesis. (16096753)
2005
20
The incidence of concha bullosa and its relationship to nasal septal deviation and paranasal sinus disease. (15502150)
2004
21
Headaches due to nasal and paranasal sinus disease. (15062525)
2004
22
The role of leukotriene inhibitors in patients with paranasal sinus disease. (12923360)
2003
23
CT characterization of inflammatory paranasal sinus disease in cystic fibrosis. (11972457)
2002
24
Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. (11195032)
2000
25
Use of standard radiography to diagnose paranasal sinus disease of asthmatic children in Taiwan: comparison with computed tomography. (10466541)
1999
26
Optic nerve blindness due to paranasal sinus disease. (10420111)
1999
27
Cytokines and chemokines in paranasal sinus diseases]. (10535064)
1999
28
Relative value of MR imaging as compared with CT in the diagnosis of inflammatory paranasal sinus disease. (9885603)
1999
29
Imaging of paranasal sinus disease. (9168874)
1997
30
Imaging in paranasal sinus disease. (9619203)
1997
31
Correlation of clinical examination with computer tomography in paranasal sinus disease. (9209590)
1997
32
Malignant plasmacytoma appearing as invasive paranasal sinus disease after cardiac transplantation. (8883660)
1996
33
Paranasal sinus disease in patients with cystic fibrosis. (8834282)
1996
34
Efficacy of systemic corticosteroid treatment for anosmia with nasal and paranasal sinus disease. (8560170)
1995
35
Nasal and paranasal sinus disease in patients with congenital velopharyngeal insufficiency. (8049050)
1994
36
Effect of a topical vasoconstrictor on computed tomography of paranasal sinus disease. (8421421)
1993
37
Endoscopic examination and treatment of paranasal sinus disease in 16 horses. (8116208)
1993
38
Inflammatory paranasal sinus disease in Bell's palsy demonstrated by magnetic resonance imaging. (8372929)
1993
39
Paranasal sinus disease in HIV antibody positive patients. (8335314)
1993
40
The prevalence of paranasal sinus disease in HIV infection and AIDS on cranial MR imaging. (8472478)
1993
41
Limited-slice CT in the evaluation of paranasal sinus disease in children. (1898816)
1991
42
Paranasal sinus disease with intracranial extension: aspergillosis versus malignancy. (3131605)
1988
43
Computed tomography in nasal and paranasal sinus disease. (6482629)
1984
44
Comparison between transillumination and the roentgenogram in diagnosing paranasal sinus disease. (7451769)
1981
45
Enzyme therapy in the triad of paranasal sinus disease, allergic asthmatic bronchitis, and bronchiectasis. (14446650)
1959
46
The changing years: their impact upon the management of paranasal sinus disease. (13647565)
1958
47
The changing years: their impact upon the management of paranasal sinus disease. (13583895)
1958
48
Chronic paranasal sinus disease in adults; factors influencing treatment. (18124358)
1949
49
Modern trends in diagnosis and treatment of paranasal sinus disease with particular reference to allergic manifestations. (20261616)
1947

Genetic Variations for Paranasal Sinus Disease

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Expression for genes affiliated with Paranasal Sinus Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paranasal Sinus Disease

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Pathways for genes affiliated with Paranasal Sinus Disease

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37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 53Reactome, 52R&D Systems, 12EMD Millipore
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Pathways related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9SERPINE1
2
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9.6IL5, IL17A
39.5PLAUR, PLAU
49.5PLAUR, PLAU
59.5PLAUR, PLAU
6
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9.3PLAU, SERPINE1
7
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9.3IL17A, IFNG
89.2IFNG, IL5
9
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9.2IFNG, IL5
109.2IL5, IFNG
119.2IL5, IFNG
129.1PLAU, IFNG
13
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8.9PLAU, PLAUR, SERPINE1
14
Hide members
8.9SERPINE1, PLAUR, PLAU
158.9SERPINE1, PLAUR, PLAU
16
Cell adhesion ECM remodeling
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8.9SERPINE1, PLAUR, PLAU
17
Translation Insulin regulation of translation
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8.9SERPINE1, PLAUR, PLAU
18
Hide members
8.8IL17A, IL5, IFNG
198.5IFNG, SERPINE1, ALOX5
20
Hide members
8.3IFNG, IL5, IL17A, ALOX5

Compounds for genes affiliated with Paranasal Sinus Disease

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
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Compounds related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1pge24410.4PLAU
2nickel44 2411.4IL5
3heparin44 28 11 2413.4ALOX5
4butyrate4410.4IL5
5rolipram44 59 2812.3ALOX5
6hydrocortisone44 2 59 1113.0PLAU
7endotoxin449.8PLAUR, SERPINE1
8Reteplase119.7PLAUR, SERPINE1
9Anistreplase119.7SERPINE1, PLAUR
10Alteplase119.7SERPINE1, PLAUR
11notoginsenoside r1449.7SERPINE1, PLAU
12nickel subsulfide449.6PLAU, SERPINE1
13dexamethasone44 49 28 1112.5ALOX5, IL5, PLAUR
145-oxoete449.5IL5, PLAUR, ALOX5
15aa861449.5IL5, ALOX5
16n-formylmethionyl-leucylphenylalanine449.4PLAUR, ALOX5, IL5
17eaca449.4PLAU, SERPINE1, PLAUR
18p-amino benzamidine449.4PLAU, PLAUR, SERPINE1
19Urokinase119.3PLAU, PLAUR, SERPINE1
20tranexamic acid44 1110.3PLAU, SERPINE1, PLAUR
21epsilon aminocaproic acid449.3PLAUR, PLAU, SERPINE1
22thapsigargin44 5910.3SERPINE1, PLAU, PLAUR
23diisopropylfluorophosphate449.3SERPINE1, PLAU, PLAUR
24cerivastatin44 49 28 1112.3PLAUR, SERPINE1, PLAU
25hirudin449.3PLAUR, PLAU, SERPINE1
26saporin449.2PLAU, PLAUR
27kininogen449.2SERPINE1, PLAU, PLAUR
28glucosamine44 11 2411.1IFNG, IL5, PLAUR
29creatinine449.1PLAUR, PLAU, IL17A
30curcumin449.0PLAUR, PLAU, IL17A, ALOX5
31aprotinin44 1110.0SERPINE1, PLAU, PLAUR
32sp 60012544 5910.0PLAU, SERPINE1, IL17A
33dmso449.0PLAUR, ALOX5, PLAU, IL5
34vitamin d448.8PLAUR, SERPINE1, IL5, ALOX5
35aspirin44 49 28 2411.8PLAUR, ALOX5, SERPINE1, PLAU
36pd 98,059448.8SERPINE1, PLAUR, PLAU, IL17A
37ly294002448.7SERPINE1, IL17A, PLAU, IL5
3815-deoxy-delta-12,14-prostaglandin j2448.7PLAU, IFNG, SERPINE1
39calcitriol44 59 11 2411.6ALOX5, PLAU, PLAUR, IFNG
40histamine44 28 2410.4IFNG, ALOX5, IL5, PLAU
41thymidine44 249.3PLAUR, PLAU, IL17A, IFNG, IL5
42herbimycin a44 599.2ALOX5, IFNG, IL5, PLAU, PLAUR
43actinomycin d448.1PLAUR, IL17A, IFNG, PLAU, SERPINE1
44tacrolimus44 49 1110.1IFNG, IL17A, SERPINE1, IL5, ALOX5
45arginine448.1IFNG, IL5, PLAU, PLAUR, ALOX5
46indomethacin44 59 28 1110.8IL5, IL17A, PLAU, PLAUR, IFNG, ALOX5
47retinoic acid44 248.8PLAUR, IFNG, IL5, PLAU, SERPINE1
48genistein44 28 59 2 11 2412.6IFNG, IL5, PLAU, PLAUR, SERPINE1, ALOX5
49sb 20358044 598.2ALOX5, PLAUR, PLAU, IL17A, IL5, IFNG
50vegf447.2PLAU, SERPINE1, ALOX5, PLAUR, IFNG, IL5

GO Terms for genes affiliated with Paranasal Sinus Disease

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16Gene Ontology
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Cellular components related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.6IL5, PLAU, PLAUR, SERPINE1, IFNG
2extracellular spaceGO:0056157.4SERPINE1, PLAU, IL17A, IL5, IFNG

Biological processes related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoclast differentiationGO:0456729.3IL17A, IFNG
2positive regulation of interleukin-23 productionGO:0327479.2IL17A, IFNG
3regulation of receptor activityGO:0104699.0SERPINE1, PLAU
4fibrinolysisGO:0427308.9SERPINE1, PLAUR, PLAU

Molecular functions related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.8IL17A, IL5, IFNG

Products for genes affiliated with Paranasal Sinus Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Paranasal Sinus Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet