Aliases & Classifications for Paranasal Sinus Disease

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Aliases & Descriptions for Paranasal Sinus Disease:

Name: Paranasal Sinus Disease 8
Paranasal Sinus Disorder 8
 
Paranasal Sinus Diseases 61
Disorder of Nasal Sinus 8


External Ids:

Disease Ontology8 DOID:1352
MeSH33 D010254
SNOMED-CT56 7393007
NCIt39 C26843

Summaries for Paranasal Sinus Disease

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Wikipedia:64 Paranasal sinuses are a group of four paired air-filled spaces that surround the nasal cavity (maxillary... more...

MalaCards based summary: Paranasal Sinus Disease, also known as paranasal sinus disorder, is related to aspergillosis and eosinophilia. An important gene associated with Paranasal Sinus Disease is IL17A (interleukin 17A), and among its related pathways are Th1 Differentiation and Th17 Differentiation. The compounds aa861 and notoginsenoside r1 have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and thyroid, and related mouse phenotypes are skeleton and digestive/alimentary.

Related Diseases for Paranasal Sinus Disease

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Diseases related to Paranasal Sinus Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1aspergillosis30.8IFNG
2eosinophilia30.2ALOX5, IFNG, IL5
3asthma29.7IFNG, IL5, PLAUR, ALOX5, IL17A
4pleurisy10.5ALOX5
5malaria10.4IFNG
6eosinophilic fasciitis10.4IL5
7eosinophilia-myalgia syndrome10.4IL5
8strongyloidiasis10.4IL5
9encephalitis10.4IL17A
10bronchiolitis10.3IL5
11carotid artery thrombosis10.3SERPINE1
12cystic fibrosis10.3
13headache10.3
14non-suppurative otitis media10.2ALOX5, IL17A
15ureter cancer10.2PLAU, PLAUR
16demyelinating disease10.2IL17A, IFNG
17paroxysmal nocturnal hemoglobinuria10.2PLAU, PLAUR
18pemphigus10.2PLAUR, PLAU
19pneumonia10.2IL5, IL17A
20allergic contact dermatitis10.2IL17A, IL5
21hepatitis b10.2IFNG, IL17A
22pemphigus vulgaris10.2PLAU, PLAUR
23allergic rhinitis10.2ALOX5, IL5
24angioedema10.2IL5, ALOX5
25sinusitis10.2IL5, ALOX5
26uveitis10.2IL17A, IFNG
27cutaneous leishmaniasis10.2IFNG, IL5
28grade iii astrocytoma10.1PLAU, PLAUR
29bronchiectasis10.1
30bronchitis10.1
31bell's palsy10.1
32eye disease10.1
33plasmacytoma10.1
34thyroiditis10.1
35blindness10.1
36sezary's disease10.1IFNG, IL5
37pulmonary fibrosis, idiopathic10.1IFNG, ALOX5
38leishmaniasis10.1IFNG, IL5
39schistosomiasis10.1IL5, IFNG
40cutaneous t cell lymphoma10.1IFNG, IL5
41colitis10.1IFNG, ALOX5, IL17A
42severe combined immunodeficiency10.1IL5, IFNG
43ulcerative colitis10.1IL17A, ALOX5, IFNG
44inflammatory bowel disease10.1IFNG, IL17A, ALOX5
45oral cancer10.1PLAU, PLAUR, ALOX5
46glioblastoma multiforme10.1PLAUR, PLAU, ALOX5
47systemic lupus erythematosus10.1IL17A, ALOX5, IFNG
48atopy10.0IL5, IFNG
49brain cancer10.0PLAU, PLAUR, ALOX5
50arthritis10.0IFNG, IL17A, ALOX5

Graphical network of the top 20 diseases related to Paranasal Sinus Disease:



Diseases related to paranasal sinus disease

Symptoms for Paranasal Sinus Disease

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Drugs & Therapeutics for Paranasal Sinus Disease

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Drug clinical trials:

Search ClinicalTrials for Paranasal Sinus Disease

Search NIH Clinical Center for Paranasal Sinus Disease

Genetic Tests for Paranasal Sinus Disease

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Anatomical Context for Paranasal Sinus Disease

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MalaCards organs/tissues related to Paranasal Sinus Disease:

31
Eye, Bone, Thyroid, T cells

Animal Models for Paranasal Sinus Disease or affiliated genes

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Publications for Paranasal Sinus Disease

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Articles related to Paranasal Sinus Disease:

(show all 46)
idTitleAuthorsYear
1
Association between diabetes and increased prevalence of paranasal sinus disease: a cross-sectional study in Japanese adults. (25728620)
2015
2
Headaches caused by nasal and paranasal sinus disease. (24703542)
2014
3
A stereological study on the correlation of inferior turbinate hypertrophy and paranasal sinus disease. (24389985)
2014
4
The impact of a patient's age on the clinical presentation of inflammatory paranasal sinus disease. (23702318)
2013
5
Prognosis for sixth nerve palsy arising from paranasal sinus disease. (24119609)
2013
6
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): treatments and long-term results of treatments. (21812808)
2012
7
Ophthalmic manifestations of paranasal sinus disease: a clinical grading system. (22411699)
2012
8
Clinical consensus statement: appropriate use of computed tomography for paranasal sinus disease. (23054429)
2012
9
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): ancillary diagnostic findings and involvement of the various sinus compartments. (21812807)
2012
10
Paranasal sinus disease in horses. (21870345)
2011
11
Complications of nose and paranasal sinus disease. (23272436)
2011
12
The expression of fibrinolytic components in chronic paranasal sinus disease. (21711960)
2011
13
Thyroid Eye Disease and Paranasal Sinus Disease. (20924307)
2010
14
Paranasal sinus disease and sputum eosinophilia in prednisone-dependent asthma. (21144367)
2010
15
T-cell regulation in chronic paranasal sinus disease. (18423831)
2008
16
Significance of blood-tinged post-nasal drip in paranasal sinus disease. (17888198)
2008
17
The incidence of concha bullosa and its relationship to nasal septal deviation and paranasal sinus disease. (15502150)
2004
18
Headaches due to nasal and paranasal sinus disease. (15062525)
2004
19
The role of leukotriene inhibitors in patients with paranasal sinus disease. (12923360)
2003
20
CT characterization of inflammatory paranasal sinus disease in cystic fibrosis. (11972457)
2002
21
Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. (11195032)
2000
22
Use of standard radiography to diagnose paranasal sinus disease of asthmatic children in Taiwan: comparison with computed tomography. (10466541)
1999
23
Optic nerve blindness due to paranasal sinus disease. (10420111)
1999
24
Cytokines and chemokines in paranasal sinus diseases]. (10535064)
1999
25
Relative value of MR imaging as compared with CT in the diagnosis of inflammatory paranasal sinus disease. (9885603)
1999
26
Imaging of paranasal sinus disease. (9168874)
1997
27
Imaging in paranasal sinus disease. (9619203)
1997
28
Correlation of clinical examination with computer tomography in paranasal sinus disease. (9209590)
1997
29
Malignant plasmacytoma appearing as invasive paranasal sinus disease after cardiac transplantation. (8883660)
1996
30
Paranasal sinus disease in patients with cystic fibrosis. (8834282)
1996
31
Efficacy of systemic corticosteroid treatment for anosmia with nasal and paranasal sinus disease. (8560170)
1995
32
Nasal and paranasal sinus disease in patients with congenital velopharyngeal insufficiency. (8049050)
1994
33
Effect of a topical vasoconstrictor on computed tomography of paranasal sinus disease. (8421421)
1993
34
Endoscopic examination and treatment of paranasal sinus disease in 16 horses. (8116208)
1993
35
Inflammatory paranasal sinus disease in Bell's palsy demonstrated by magnetic resonance imaging. (8372929)
1993
36
Paranasal sinus disease in HIV antibody positive patients. (8335314)
1993
37
The prevalence of paranasal sinus disease in HIV infection and AIDS on cranial MR imaging. (8472478)
1993
38
Limited-slice CT in the evaluation of paranasal sinus disease in children. (1898816)
1991
39
Paranasal sinus disease with intracranial extension: aspergillosis versus malignancy. (3131605)
1988
40
Computed tomography in nasal and paranasal sinus disease. (6482629)
1984
41
Comparison between transillumination and the roentgenogram in diagnosing paranasal sinus disease. (7451769)
1981
42
Enzyme therapy in the triad of paranasal sinus disease, allergic asthmatic bronchitis, and bronchiectasis. (14446650)
1959
43
The changing years: their impact upon the management of paranasal sinus disease. (13647565)
1958
44
The changing years: their impact upon the management of paranasal sinus disease. (13583895)
1958
45
Chronic paranasal sinus disease in adults; factors influencing treatment. (18124358)
1949
46
Modern trends in diagnosis and treatment of paranasal sinus disease with particular reference to allergic manifestations. (20261616)
1947

Variations for Paranasal Sinus Disease

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Expression for genes affiliated with Paranasal Sinus Disease

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Search GEO for disease gene expression data for Paranasal Sinus Disease.

Pathways for genes affiliated with Paranasal Sinus Disease

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Pathways related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL27-mediated signaling events36
9.6IFNG, IL17A
2
Show member pathways
9.6IFNG, IL17A
39.6IL17A, IFNG
49.5PLAUR, PLAU
59.5PLAUR, PLAU
69.5PLAU, PLAUR
79.4ALOX5, IL5
89.4PLAU, IFNG
99.3IFNG, IL5
109.3IFNG, IL5
119.3IFNG, IL5
129.3IL5, IFNG
13
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.3IL5, IFNG
149.3IL5, IFNG
159.2PLAUR, SERPINE1
169.1PLAU, SERPINE1
17
Show member pathways
9.1PLAU, SERPINE1
189.1SERPINE1, IFNG
199.0IL5, SERPINE1
20
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.0IL17A, IL5, IFNG
21
Show member pathways
thioredoxin pathway36
8.7ALOX5, IFNG, SERPINE1
22
Show member pathways
8.7PLAUR, SERPINE1, PLAU
23
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.7PLAUR, SERPINE1, PLAU
24
Show member pathways
Metalloproteases in connective tissue degradation
8.7PLAUR, PLAU, SERPINE1
25
Show member pathways
8.7PLAU, PLAUR, SERPINE1
26
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
8.7PLAUR, SERPINE1, PLAU
278.7SERPINE1, PLAU, PLAUR
288.6SERPINE1, PLAU, IFNG
29
Show member pathways
8.5ALOX5, IL5, IL17A, IFNG
30
Show member pathways
8.5IL17A, ALOX5, IL5, IFNG

Compounds for genes affiliated with Paranasal Sinus Disease

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Compounds related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1aa861449.4ALOX5, IL5
2notoginsenoside r1449.4PLAU, SERPINE1
35-oxoete449.4ALOX5, PLAUR, IL5
4saporin449.4PLAUR, PLAU
5nickel44 2410.4IL5, PLAUR, IL17A
6nickel subsulfide449.3PLAU, SERPINE1
7n-formylmethionyl-leucylphenylalanine449.3IL5, ALOX5, PLAUR
8rolipram44 60 2811.3IFNG, IL5, ALOX5
9glucosamine44 24 1111.2PLAUR, IL5, IFNG
10curcumin449.1PLAU, IL17A, ALOX5, PLAUR
11eaca449.1PLAUR, SERPINE1, PLAU
12p-amino benzamidine449.1PLAU, PLAUR, SERPINE1
13tranexamic acid44 1110.1PLAU, PLAUR, SERPINE1
14epsilon aminocaproic acid449.1PLAUR, SERPINE1, PLAU
15diisopropylfluorophosphate449.1SERPINE1, PLAU, PLAUR
16cerivastatin50 44 28 1112.0SERPINE1, PLAU, PLAUR
17hirudin449.0PLAU, SERPINE1, PLAUR
18calcitriol44 60 24 1112.0IFNG, ALOX5, PLAU, PLAUR
19kininogen448.9PLAU, PLAUR, SERPINE1
20hydrocortisone44 1 60 1111.9PLAU, IL5, IFNG
21sp 60012544 609.9IL17A, SERPINE1, PLAU
22dmso448.9PLAUR, PLAU, ALOX5, IL5
23aprotinin44 119.9PLAUR, SERPINE1, PLAU
2415-deoxy-delta-12,14-prostaglandin j2448.8PLAU, IFNG, SERPINE1
25histamine44 28 2410.7ALOX5, PLAU, IL5, IFNG
26endotoxin448.7IL17A, IFNG, PLAUR, SERPINE1
27butyrate448.7IFNG, PLAU, PLAUR, IL5
28tgf beta1448.7PLAUR, PLAU, SERPINE1
29thapsigargin44 609.7PLAU, PLAUR, ALOX5, SERPINE1
30aspirin44 50 28 2411.6PLAU, SERPINE1, ALOX5, PLAUR
31pd 98,059448.6IL17A, SERPINE1, PLAUR, PLAU
32vitamin d448.5IL5, PLAUR, ALOX5, SERPINE1
33creatinine448.5PLAU, PLAUR, SERPINE1, IL17A
34thymidine44 249.4IL17A, PLAUR, IFNG, PLAU, IL5
35ly294002448.4IL5, SERPINE1, IL17A, PLAU
36herbimycin a44 609.4IL5, PLAUR, ALOX5, IFNG, PLAU
37arginine448.3PLAU, ALOX5, IL5, PLAUR, IFNG
38actinomycin d448.2PLAUR, SERPINE1, PLAU, IFNG, IL17A
39estrogen448.2ALOX5, PLAU, PLAUR, IL17A, SERPINE1
40h2o2448.2ALOX5, PLAU, PLAUR, IL5
41tacrolimus44 50 1110.2ALOX5, IL17A, IL5, IFNG, SERPINE1
42heparin44 28 24 1111.1IL5, ALOX5, SERPINE1, PLAUR, PLAU
43indomethacin44 28 60 1111.0PLAU, IFNG, PLAUR, IL17A, ALOX5, IL5
44pge2448.0ALOX5, IFNG, IL5, IL17A, PLAUR, PLAU
45retinoic acid44 248.8PLAU, SERPINE1, IFNG, PLAUR, IL5
46dexamethasone44 50 28 1110.7SERPINE1, IFNG, IL5, IL17A, PLAUR, ALOX5
47genistein44 28 60 1 24 1112.6ALOX5, PLAUR, IFNG, SERPINE1, PLAU, IL5
48cycloheximide447.6SERPINE1, ALOX5, IFNG, IL5, PLAUR, PLAU
49sb 20358044 608.2IL5, ALOX5, PLAU, PLAUR, IL17A, IFNG
50vegf447.2ALOX5, PLAU, PLAUR, IL17A, SERPINE1, IL5

GO Terms for genes affiliated with Paranasal Sinus Disease

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Cellular components related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.5PLAU, PLAUR, IL5, IFNG, SERPINE1
2extracellular spaceGO:00056156.9ALOX5, SERPINE1, IFNG, IL5, IL17A, PLAU

Biological processes related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-23 productionGO:00327479.7IL17A, IFNG
2positive regulation of osteoclast differentiationGO:00456729.6IFNG, IL17A
3cellular component movementGO:00069289.5PLAUR, IFNG
4regulation of receptor activityGO:00104699.2PLAU, SERPINE1
5cellular response to lipopolysaccharideGO:00712228.8IFNG, SERPINE1
6fibrinolysisGO:00427308.8PLAU, PLAUR, SERPINE1
7blood coagulationGO:00075968.6PLAU, PLAUR, SERPINE1

Molecular functions related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.0IL17A, IL5, IFNG

Sources for Paranasal Sinus Disease

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet