Paranasal Sinus Disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Paranasal Sinus Disease

Sources:
⁶⁴Wikipedia, ³²MalaCards
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Wikipedia:⁶⁴ Paranasal sinuses are a group of four paired air-filled spaces that surround the nasal cavity (maxillary... more...

MalaCards based summary: Paranasal Sinus Disease, also known as disorder of nasal sinus, is related to aspergillosis and eosinophilia. An important gene associated with Paranasal Sinus Disease is IL17A (interleukin 17A), and among its related pathways are Th1 Differentiation and Th17 Differentiation. The compounds aa861 and notoginsenoside r1 have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and thyroid, and related mouse phenotypes are skeleton and digestive/alimentary.

Aliases & Classifications for Paranasal Sinus Disease

Sources:
⁹Disease Ontology, ⁶¹UMLS, ³⁹NCIt, ⁵⁶SNOMED-CT, ³⁴MeSH
See all sources

Paranasal Sinus Disease, Aliases & Descriptions:

Name: Paranasal Sinus Disease ⁹

Disorder of Nasal Sinus ⁹ ⁶¹

Paranasal Sinus Disorder ⁹

Paranasal Sinus Diseases ⁶¹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases

External Ids:

Disease Ontology⁹ DOID:1352

NCIt³⁹ C26843

SNOMED-CT⁵⁶ 7393007

MeSH³⁴ D010254

UMLS⁶¹ C0030469

Related Diseases for Paranasal Sinus Disease

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Paranasal Sinus Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 78)

id	Related Disease	Score	Top Affiliating Genes
1	aspergillosis	30.8	IFNG
2	eosinophilia	30.2	IFNG, IL5, ALOX5
3	asthma	29.7	ALOX5, PLAUR, IL17A, IL5, IFNG
4	pleurisy	10.5	ALOX5
5	malaria	10.4	IFNG
6	eosinophilic fasciitis	10.4	IL5
7	eosinophilia-myalgia syndrome	10.4	IL5
8	strongyloidiasis	10.4	IL5
9	encephalitis	10.4	IL17A
10	bronchiolitis	10.4	IL5
11	carotid artery thrombosis	10.3	SERPINE1
12	cystic fibrosis	10.3
13	headache	10.3
14	non-suppurative otitis media	10.3	ALOX5, IL17A
15	ureter cancer	10.2	PLAUR, PLAU
16	demyelinating disease	10.2	IL17A, IFNG
17	paroxysmal nocturnal hemoglobinuria, somatic	10.2	PLAU, PLAUR
18	pemphigus	10.2	PLAUR, PLAU
19	pneumonia	10.2	IL17A, IL5
20	allergic contact dermatitis	10.2	IL17A, IL5
21	hepatitis b	10.2	IL17A, IFNG
22	pemphigus vulgaris	10.2	PLAU, PLAUR
23	allergic rhinitis	10.2	IL5, ALOX5
24	uveitis	10.2	IFNG, IL17A
25	angioedema	10.2	ALOX5, IL5
26	sinusitis	10.2	ALOX5, IL5
27	cutaneous leishmaniasis	10.2	IFNG, IL5
28	grade iii astrocytoma	10.1	PLAUR, PLAU
29	sezary's disease	10.1	IFNG, IL5
30	idiopathic pulmonary fibrosis	10.1	ALOX5, IFNG
31	bronchitis	10.1
32	bronchiectasis	10.1
33	bell's palsy	10.1
34	eye disease	10.1
35	plasmacytoma	10.1
36	thyroiditis	10.1
37	blindness	10.1
38	leishmaniasis	10.1	IL5, IFNG
39	schistosomiasis	10.1	IL5, IFNG
40	cutaneous t cell lymphoma	10.1	IL5, IFNG
41	colitis	10.1	ALOX5, IL17A, IFNG
42	severe combined immunodeficiency	10.1	IL5, IFNG
43	ulcerative colitis	10.1	ALOX5, IL17A, IFNG
44	inflammatory bowel disease	10.1	ALOX5, IL17A, IFNG
45	oral cancer	10.1	ALOX5, PLAU, PLAUR
46	glioblastoma multiforme	10.1	PLAUR, PLAU, ALOX5
47	systemic lupus erythematosus	10.1	IFNG, IL17A, ALOX5
48	atopy	10.1	IL5, IFNG
49	brain cancer	10.0	PLAUR, PLAU, ALOX5
50	arthritis	10.0	ALOX5, IL17A, IFNG

Graphical network of the top 20 diseases related to Paranasal Sinus Disease:

Symptoms for Paranasal Sinus Disease

Drugs & Therapeutics for Paranasal Sinus Disease

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Paranasal Sinus Disease

Search NIH Clinical Center for Paranasal Sinus Disease

Genetic Tests for Paranasal Sinus Disease

Anatomical Context for Paranasal Sinus Disease

Sources:
³²MalaCards
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MalaCards organs/tissues related to Paranasal Sinus Disease:

³²

Eye, Bone, Thyroid, T cells

Animal Models for Paranasal Sinus Disease or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Paranasal Sinus Disease:

³⁶ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	skeleton phenotype	MP:0005390	8.6	ALOX5, PLAU, IL17A, IFNG
2	digestive/alimentary phenotype	MP:0005381	8.3	PLAU, IL17A, IL5, IFNG
3	renal/urinary system phenotype	MP:0005367	8.3	SERPINE1, IFNG, IL17A, PLAUR
4	tumorigenesis	MP:0002006	8.1	PLAU, IL5, IFNG, SERPINE1
5	cardiovascular system phenotype	MP:0005385	7.9	SERPINE1, IFNG, PLAUR, PLAU, ALOX5
6	liver/biliary system phenotype	MP:0005370	7.7	SERPINE1, IFNG, IL5, PLAUR, PLAU
7	respiratory system phenotype	MP:0005388	7.4	SERPINE1, IFNG, IL5, IL17A, PLAUR, PLAU
8	growth/size/body phenotype	MP:0005378	7.2	SERPINE1, IFNG, IL5, PLAUR, PLAU
9	hematopoietic system phenotype	MP:0005397	7.0	ALOX5, SERPINE1, IFNG, IL5, IL17A, PLAUR
10	immune system phenotype	MP:0005387	6.9	SERPINE1, IFNG, IL5, IL17A, PLAUR, PLAU
11	homeostasis/metabolism phenotype	MP:0005376	6.9	SERPINE1, IFNG, IL5, IL17A, PLAUR, PLAU

Publications for Paranasal Sinus Disease

Sources:
⁵¹PubMed
See all sources

Articles related to Paranasal Sinus Disease:

(show all 44)

id	Title	Authors	Year
1	Headaches caused by nasal and paranasal sinus disease. (24703542)	Marmura M.J.... Silberstein S.D.	2014
2	A stereological study on the correlation of inferior turbinate hypertrophy and paranasal sinus disease. (24389985)	Ural A.... Candan H.	2014
3	The impact of a patient's age on the clinical presentation of inflammatory paranasal sinus disease. (23702318)	Busaba N.Y.	2013
4	Prognosis for sixth nerve palsy arising from paranasal sinus disease. (24119609)	Miller C.... Chiu A.G.	2013
5	Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): treatments and long-term results of treatments. (21812808)	Dixon P.M.... Barakzai S.Z.	2012
6	Ophthalmic manifestations of paranasal sinus disease: a clinical grading system. (22411699)	Al Anazy F.H.... Al Dousary S.H.	2012
7	Clinical consensus statement: appropriate use of computed tomography for paranasal sinus disease. (23054429)	Setzen G.... Patel M.M.	2012
8	Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): ancillary diagnostic findings and involvement of the various sinus compartments. (21812807)	Dixon P.M.... Barakzai S.Z.	2012
9	Paranasal sinus disease in horses. (21870345)	Waguespack R.W.... Taintor J.	2011
10	Complications of nose and paranasal sinus disease. (23272436)	Sajid T.... Khan J.	2011
11	The expression of fibrinolytic components in chronic paranasal sinus disease. (21711960)	Sejima T.... Bachert C.	2011
12	Thyroid Eye Disease and Paranasal Sinus Disease. (20924307)	Wiwanitkit V.	2010
13	Paranasal sinus disease and sputum eosinophilia in prednisone-dependent asthma. (21144367)	Lui B.T.... Nair P.	2010
14	T-cell regulation in chronic paranasal sinus disease. (18423831)	Van Bruaene N.... Gevaert P.	2008
15	Significance of blood-tinged post-nasal drip in paranasal sinus disease. (17888198)	Chao T.K.... Huang W.H.	2008
16	The incidence of concha bullosa and its relationship to nasal septal deviation and paranasal sinus disease. (15502150)	Stallman J.S.... Som P.M.	2004
17	Headaches due to nasal and paranasal sinus disease. (15062525)	Silberstein S.D.	2004
18	The role of leukotriene inhibitors in patients with paranasal sinus disease. (12923360)	Parnes S.M.	2003
19	CT characterization of inflammatory paranasal sinus disease in cystic fibrosis. (11972457)	EggesbA... Kolmannskog F.	2002
20	Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. (11195032)	Bachmann G.... Michel O.	2000
21	Optic nerve blindness due to paranasal sinus disease. (10420111)	Fujimoto N.... Nagata H.	1999
22	Cytokines and chemokines in paranasal sinus diseases]. (10535064)	Rudack C.... Bachert C.	1999
23	Relative value of MR imaging as compared with CT in the diagnosis of inflammatory paranasal sinus disease. (9885603)	HAohnel S.... Jansen O.	1999
24	Imaging of paranasal sinus disease. (9168874)	Bangert B.A.	1997
25	Imaging in paranasal sinus disease. (9619203)	Teh J.... Smith A.	1997
26	Correlation of clinical examination with computer tomography in paranasal sinus disease. (9209590)	Casiano R.R.	1997
27	Malignant plasmacytoma appearing as invasive paranasal sinus disease after cardiac transplantation. (8883660)	Kramer G.S.... Gatenby R.A.	1996
28	Paranasal sinus disease in patients with cystic fibrosis. (8834282)	Nishioka G.J.... Cook P.R.	1996
29	Efficacy of systemic corticosteroid treatment for anosmia with nasal and paranasal sinus disease. (8560170)	Ikeda K.... Takasaka T.	1995
30	Nasal and paranasal sinus disease in patients with congenital velopharyngeal insufficiency. (8049050)	Ishikawa Y.... Amitani R.	1994
31	Effect of a topical vasoconstrictor on computed tomography of paranasal sinus disease. (8421421)	Stringer S.P.... Avino A.J.	1993
32	Endoscopic examination and treatment of paranasal sinus disease in 16 horses. (8116208)	Ruggles A.J.... Freeman D.E.	1993
33	Inflammatory paranasal sinus disease in Bell's palsy demonstrated by magnetic resonance imaging. (8372929)	Stenquist M.... Jonsson L.	1993
34	Paranasal sinus disease in HIV antibody positive patients. (8335314)	Grant A.... Miller R.F.	1993
35	The prevalence of paranasal sinus disease in HIV infection and AIDS on cranial MR imaging. (8472478)	Chong W.K.... Harrison M.J.	1993
36	Limited-slice CT in the evaluation of paranasal sinus disease in children. (1898816)	Gross G.W.... Ehrlich S.M.	1991
37	Paranasal sinus disease with intracranial extension: aspergillosis versus malignancy. (3131605)	Sarti E.J.... Camins M.B.	1988
38	Computed tomography in nasal and paranasal sinus disease. (6482629)	Unger J.M.... Duncavage J.A.	1984
39	Comparison between transillumination and the roentgenogram in diagnosing paranasal sinus disease. (7451769)	Spector S.L.... Philpot I.	1981
40	Enzyme therapy in the triad of paranasal sinus disease, allergic asthmatic bronchitis, and bronchiectasis. (14446650)	SILBERT N.E.	1959
41	The changing years: their impact upon the management of paranasal sinus disease. (13647565)	HILL F.T.	1958
42	The changing years: their impact upon the management of paranasal sinus disease. (13583895)	HILL F.T.	1958
43	Chronic paranasal sinus disease in adults; factors influencing treatment. (18124358)	Gill J.P.	1949
44	Modern trends in diagnosis and treatment of paranasal sinus disease with particular reference to allergic manifestations. (20261616)	GILL E.K.	1947

Genes related to Paranasal Sinus Disease

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Paranasal Sinus Disease:

- Elite gene

id	Symbol	Description	Score	Implication
1	IL17A	interleukin 17A	21.50	GeneCards inferred via : Publications (show sections)
2	ALOX5	arachidonate 5-lipoxygenase	18.64	GeneCards inferred via : Publications (show sections)
3	PLAUR	plasminogen activator, urokinase receptor	15.79	GeneCards inferred via : Publications (show sections)
4	PLAU	plasminogen activator, urokinase	12.93	GeneCards inferred via : Publications (show sections)
5	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	10.07	GeneCards inferred via : Publications (show sections)
6	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	7.21	GeneCards inferred via : Publications (show sections)
7	IFNG	interferon, gamma	4.36	GeneCards inferred via : Publications (show sections)

Products for genes related to Paranasal Sinus Disease disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	7	-	7	7
2	Novus Biologicals	6	6	7	-

Variations for Paranasal Sinus Disease

Expression for genes affiliated with Paranasal Sinus Disease

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Paranasal Sinus Disease

Search GEO for disease gene expression data for Paranasal Sinus Disease.

Pathways for genes affiliated with Paranasal Sinus Disease

Sources:
⁴⁹PathCards, ⁵³R&D Systems, ³⁷NCBI BioSystems Database, ³⁰KEGG, ⁵²QIAGEN, ⁵Cell Signaling Technology, ⁵⁴Reactome, ⁵⁹Thomson Reuters, ¹³EMD Millipore
See all sources

Pathways related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show all 30)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Th1 Differentiation⁵³ Show member pathways IL27-mediated signaling events³⁷	9.6	IFNG, IL17A
2	Th17 Differentiation⁵³ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types⁵³	9.6	IFNG, IL17A
3	Rheumatoid arthritis³⁰	9.6	IL17A, IFNG
4	amb2 Integrin signaling³⁷	9.5	PLAU, PLAUR
5	Validated transcriptional targets of AP1 family members Fra1 and Fra2³⁷	9.5	PLAU, PLAUR
6	FGF signaling pathway³⁷	9.5	PLAUR, PLAU
7	IL-5 Signaling Pathway³⁷	9.4	ALOX5, IL5
8	ATF-2 transcription factor network³⁷	9.4	IFNG, PLAU
9	Calcineurin-regulated NFAT-dependent transcription in lymphocytes³⁷ Show member pathways Calcium signaling in the CD4+ TCR pathway³⁷	9.3	IFNG, IL5
10	OX40 Pathway⁵²	9.3	IFNG, IL5
11	Cytokine Network⁵²	9.3	IFNG, IL5
12	Glucocorticoid receptor regulatory network³⁷	9.3	IL5, IFNG
13	Inflammatory Response Pathway³⁷	9.3	IL5, IFNG
14	Cytokines and Inflammatory Response³⁷	9.3	IL5, IFNG
15	Adhesion⁵	9.2	PLAUR, SERPINE1
16	E2F transcription factor network³⁷	9.1	PLAU, SERPINE1
17	Formation of Fibrin Clot (Clotting Cascade)⁵⁴ Show member pathways Common Pathway⁵⁴ Blood Clotting Cascade³⁷ Extrinsic Pathway⁵⁴ Intrinsic Pathway⁵⁴ Extrinsic Prothrombin Activation Pathway⁵² Blood Coagulation Signaling Pathways⁵³	9.1	SERPINE1, PLAU
18	TGF Beta Signaling Pathway³⁷	9.1	SERPINE1, IFNG
19	Regulation of nuclear SMAD2/3 signaling³⁷	9.0	IL5, SERPINE1
20	B Cell Receptor Signaling Pathway³⁷ Show member pathways B cell receptor signaling pathway³⁰ BCR signaling pathway³⁷ TCR Signaling Pathway³⁷ T cell receptor signaling pathway³⁰	9.0	IL17A, IL5, IFNG
21	Selenium Pathway³⁷ Show member pathways thioredoxin pathway³⁷	8.7	ALOX5, IFNG, SERPINE1
22	Integrin Pathway⁵² Show member pathways Inhibition of Angiogenesis by TSP1⁵² Transendothelial Migration of Leukocytes⁵² FAK1 Signaling⁵² GnRH Signaling⁵² UPA-UPAR Pathway⁵²	8.7	SERPINE1, PLAUR, PLAU
23	Translation Insulin regulation of translation⁵⁹ Show member pathways Transcription Receptor mediated HIF regulation⁵⁹ Development CNTF receptor signaling⁵⁹ Class IB PI3K non-lipid kinase events³⁷ mTOR signaling pathway³⁰ Insulin signaling pathway³⁰ ErbB2/ErbB3 signaling events³⁷ Development Growth hormone signaling via PI3K AKT and MAPK cascades⁵⁹ Translation Regulation activity of EIF2⁵⁹ Regulation of lipid metabolism Insulin signaling generic cascades⁵⁹ Transcription PPAR Pathway⁵⁹ Cell adhesion PLAU signaling⁵⁹ Recycling of eIF2-GDP⁵⁴ Translation Regulation activity of EIF4F⁵⁹	8.7	PLAU, PLAUR, SERPINE1
24	Cell adhesion ECM remodeling⁵⁹ Show member pathways Metalloproteases in connective tissue degradation¹³	8.7	PLAU, PLAUR, SERPINE1
25	Dissolution of Fibrin Clot⁵⁴	8.7	PLAU, PLAUR, SERPINE1
26	Hemostasis⁵⁴ Show member pathways Platelet activation, signaling and aggregation⁵⁴	8.7	PLAU, PLAUR, SERPINE1
27	Complement and coagulation cascades³⁰ Show member pathways Complement Activation, Classical Pathway³⁷ Complement and Coagulation Cascades³⁷	8.7	SERPINE1, PLAUR, PLAU
28	Senescence and Autophagy³⁷	8.6	SERPINE1, IFNG, PLAU
29	Leishmaniasis³⁰ Show member pathways Toxoplasmosis³⁰ Inflammatory bowel disease (IBD)³⁰	8.5	ALOX5, IL17A, IL5, IFNG
30	PEDF Induced Signaling⁵² Show member pathways all-trans-Retinoic Acid Signaling in Brain⁵² Cytokine-cytokine receptor interaction³⁰ NFAT Signaling and Lymphocyte Interactions⁵² STAT3 Pathway⁵² RAR-Gamma-RXR-Alpha Degradation⁵² PGC1Alpha Pathway⁵² Glucocorticoid Receptor Signaling⁵² IL-6 Pathway⁵² Endothelin-1 Signaling Pathway⁵² MIF Regulation of Innate Immune Cells⁵² MIF Mediated Glucocorticoid Regulation⁵²	8.5	ALOX5, IL17A, IL5, IFNG

Compounds for genes affiliated with Paranasal Sinus Disease

Sources:
⁴⁴Novoseek, ²⁵HMDB, ⁶⁰Tocris Bioscience, ²⁹IUPHAR, ¹²DrugBank, ⁵⁰PharmGKB, ³BitterDB
See all sources

Compounds related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show top 50) (show all 134)

id	Compound	Score	Top Affiliating Genes
1	aa861⁴⁴	9.4	ALOX5, IL5
2	notoginsenoside r1⁴⁴	9.4	PLAU, SERPINE1
3	5-oxoete⁴⁴	9.4	ALOX5, PLAUR, IL5
4	saporin⁴⁴	9.4	PLAUR, PLAU
5	nickel⁴⁴ ²⁵	10.4	IL5, PLAUR, IL17A
6	nickel subsulfide⁴⁴	9.3	PLAU, SERPINE1
7	n-formylmethionyl-leucylphenylalanine⁴⁴	9.3	IL5, ALOX5, PLAUR
8	rolipram⁴⁴ ⁶⁰ ²⁹	11.3	IFNG, IL5, ALOX5
9	glucosamine⁴⁴ ²⁵ ¹²	11.2	PLAUR, IL5, IFNG
10	curcumin⁴⁴	9.1	PLAU, IL17A, ALOX5, PLAUR
11	eaca⁴⁴	9.1	PLAUR, SERPINE1, PLAU
12	p-amino benzamidine⁴⁴	9.1	PLAU, PLAUR, SERPINE1
13	tranexamic acid⁴⁴ ¹²	10.1	PLAU, PLAUR, SERPINE1
14	epsilon aminocaproic acid⁴⁴	9.1	PLAUR, SERPINE1, PLAU
15	diisopropylfluorophosphate⁴⁴	9.1	SERPINE1, PLAU, PLAUR
16	cerivastatin⁵⁰ ⁴⁴ ²⁹ ¹²	12.0	SERPINE1, PLAU, PLAUR
17	hirudin⁴⁴	9.0	PLAU, SERPINE1, PLAUR
18	calcitriol⁴⁴ ⁶⁰ ²⁵ ¹²	12.0	IFNG, ALOX5, PLAU, PLAUR
19	kininogen⁴⁴	8.9	PLAU, PLAUR, SERPINE1
20	hydrocortisone⁴⁴ ³ ⁶⁰ ¹²	11.9	PLAU, IL5, IFNG
21	sp 600125⁴⁴ ⁶⁰	9.9	IL17A, SERPINE1, PLAU
22	dmso⁴⁴	8.9	PLAUR, PLAU, ALOX5, IL5
23	aprotinin⁴⁴ ¹²	9.9	PLAUR, SERPINE1, PLAU
24	15-deoxy-delta-12,14-prostaglandin j2⁴⁴	8.8	PLAU, IFNG, SERPINE1
25	histamine⁴⁴ ²⁹ ²⁵	10.7	ALOX5, PLAU, IL5, IFNG
26	endotoxin⁴⁴	8.7	IL17A, IFNG, PLAUR, SERPINE1
27	butyrate⁴⁴	8.7	IFNG, PLAU, PLAUR, IL5
28	tgf beta1⁴⁴	8.7	PLAUR, PLAU, SERPINE1
29	thapsigargin⁴⁴ ⁶⁰	9.7	PLAU, PLAUR, ALOX5, SERPINE1
30	aspirin⁴⁴ ⁵⁰ ²⁹ ²⁵	11.6	PLAU, SERPINE1, ALOX5, PLAUR
31	pd 98,059⁴⁴	8.6	IL17A, SERPINE1, PLAUR, PLAU
32	vitamin d⁴⁴	8.5	IL5, PLAUR, ALOX5, SERPINE1
33	creatinine⁴⁴	8.5	PLAU, PLAUR, SERPINE1, IL17A
34	thymidine⁴⁴ ²⁵	9.4	IL17A, PLAUR, IFNG, PLAU, IL5
35	ly294002⁴⁴	8.4	IL5, SERPINE1, IL17A, PLAU
36	herbimycin a⁴⁴ ⁶⁰	9.4	IL5, PLAUR, ALOX5, IFNG, PLAU
37	arginine⁴⁴	8.3	PLAU, ALOX5, IL5, PLAUR, IFNG
38	actinomycin d⁴⁴	8.2	PLAUR, SERPINE1, PLAU, IFNG, IL17A
39	estrogen⁴⁴	8.2	ALOX5, PLAU, PLAUR, IL17A, SERPINE1
40	h2o2⁴⁴	8.2	ALOX5, PLAU, PLAUR, IL5
41	tacrolimus⁴⁴ ⁵⁰ ¹²	10.2	ALOX5, IL17A, IL5, IFNG, SERPINE1
42	heparin⁴⁴ ²⁹ ²⁵ ¹²	11.1	IL5, ALOX5, SERPINE1, PLAUR, PLAU
43	indomethacin⁴⁴ ²⁹ ⁶⁰ ¹²	11.0	PLAU, IFNG, PLAUR, IL17A, ALOX5, IL5
44	pge2⁴⁴	8.0	ALOX5, IFNG, IL5, IL17A, PLAUR, PLAU
45	retinoic acid⁴⁴ ²⁵	8.8	PLAU, SERPINE1, IFNG, PLAUR, IL5
46	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	10.7	SERPINE1, IFNG, IL5, IL17A, PLAUR, ALOX5
47	genistein⁴⁴ ²⁹ ⁶⁰ ³ ²⁵ ¹²	12.6	ALOX5, PLAUR, IFNG, SERPINE1, PLAU, IL5
48	cycloheximide⁴⁴	7.6	SERPINE1, ALOX5, IFNG, IL5, PLAUR, PLAU
49	sb 203580⁴⁴ ⁶⁰	8.2	IL5, ALOX5, PLAU, PLAUR, IL17A, IFNG
50	vegf⁴⁴	7.2	ALOX5, PLAU, PLAUR, IL17A, SERPINE1, IL5

GO Terms for genes affiliated with Paranasal Sinus Disease

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	7.5	PLAU, PLAUR, IL5, IFNG, SERPINE1
2	extracellular space	GO:005615	6.9	ALOX5, SERPINE1, IFNG, IL5, IL17A, PLAU

Biological processes related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of interleukin-23 production	GO:032747	9.7	IL17A, IFNG
2	positive regulation of osteoclast differentiation	GO:045672	9.6	IFNG, IL17A
3	cellular component movement	GO:006928	9.5	PLAUR, IFNG
4	regulation of receptor activity	GO:010469	9.2	PLAU, SERPINE1
5	cellular response to lipopolysaccharide	GO:071222	8.8	IFNG, SERPINE1
6	fibrinolysis	GO:042730	8.8	PLAU, PLAUR, SERPINE1
7	blood coagulation	GO:007596	8.6	PLAU, PLAUR, SERPINE1

Molecular functions related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:005125	9.0	IL17A, IL5, IFNG

Products for genes affiliated with Paranasal Sinus Disease

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Paranasal Sinus Disease

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

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MCID: PRN021 MIFTS: 47	Paranasal Sinus Disease malady Respiratory diseases category
7 genes, 4 tissues, 78 related diseases, clinical trials Download this MalaCard Expand all tables

Paranasal Sinus Disease malady