MCID: PRN021
MIFTS: 47

Paranasal Sinus Disease malady

Respiratory diseases category

Summaries for Paranasal Sinus Disease

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66Wikipedia, 34MalaCards
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Wikipedia:66 Paranasal sinuses are a group of four paired air-filled spaces that surround the nasal cavity (maxillary... more...

MalaCards: Paranasal Sinus Disease, also known as paranasal sinus disorder, is related to aspergillosis and bronchitis. An important gene associated with Paranasal Sinus Disease is IL17A (interleukin 17A), and among its related pathways are Th1 Differentiation and Th17 Differentiation. The compounds aa861 and notoginsenoside r1 have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and thyroid, and related mouse phenotypes are skeleton and digestive/alimentary.

Aliases & Classifications for Paranasal Sinus Disease

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Sources:
9Disease Ontology, 63UMLS, 36MeSH, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

paranasal sinus disease 9
paranasal sinus disorder 9
paranasal sinus diseases 63
disorder of nasal sinus 9


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Disease Ontology9 DOID:1352
MeSH36 D010254
SNOMED-CT59 7393007
NCIt41 C26843

Related Diseases for Paranasal Sinus Disease

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Paranasal Sinus Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1aspergillosis30.3IFNG
2bronchitis30.3ALOX5, IL17A
3cystic fibrosis10.3
4bronchiectasis10.1
5bell's palsy10.1
6eye disease10.1
7plasmacytoma10.1
8thyroiditis10.1
9headache10.1
10blindness10.1
11pleurisy10.1ALOX5
12malaria10.1IFNG
13eosinophilic fasciitis10.1IL5
14eosinophilia-myalgia syndrome10.1IL5
15strongyloidiasis10.1IL5
16encephalitis10.1IL17A
17bronchiolitis10.1IL5
18carotid artery thrombosis10.1SERPINE1
19ureter cancer10.1PLAU, PLAUR
20paroxysmal nocturnal hemoglobinuria10.1PLAU, PLAUR
21pemphigus10.1PLAUR, PLAU
22pneumonia10.1IL5, IL17A
23allergic contact dermatitis10.0IL17A, IL5
24hepatitis b10.0IFNG, IL17A
25pemphigus vulgaris10.0PLAU, PLAUR
26allergic rhinitis10.0ALOX5, IL5
27angioedema10.0IL5, ALOX5
28uveitis10.0IL17A, IFNG
29sinusitis10.0IL5, ALOX5
30cutaneous leishmaniasis10.0IFNG, IL5
31anaplastic astrocytoma10.0PLAU, PLAUR
32sezary's disease10.0IFNG, IL5
33idiopathic pulmonary fibrosis10.0IFNG, ALOX5
34leishmaniasis10.0IFNG, IL5
35schistosomiasis10.0IL5, IFNG
36cutaneous t cell lymphoma10.0IFNG, IL5
37encephalomyelitis10.0IL17A, ALOX5, IFNG
38severe combined immunodeficiency10.0IL5, IFNG
39ulcerative colitis10.0IL17A, ALOX5, IFNG
40inflammatory bowel disease10.0IFNG, IL17A, ALOX5
41oral cancer10.0PLAU, PLAUR, ALOX5
42glioblastoma multiforme10.0PLAUR, PLAU, ALOX5
43systemic lupus erythematosus10.0IL17A, ALOX5, IFNG
44atopy10.0IL5, IFNG
45brain cancer10.0PLAU, PLAUR, ALOX5
46arthritis10.0IFNG, IL17A, ALOX5
47colorectal cancer10.0ALOX5, PLAU, PLAUR
48atopic dermatitis10.0IL5, IFNG, IL17A
49tetanus10.0IFNG, IL5
50skin disease10.0IL5, IFNG, IL17A

Graphical network of the top 20 diseases related to Paranasal Sinus Disease:



Diseases related to paranasal sinus disease

Symptoms for Paranasal Sinus Disease

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Drugs & Therapeutics for Paranasal Sinus Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Paranasal Sinus Disease

Drug clinical trials:

Search ClinicalTrials for Paranasal Sinus Disease

Search NIH Clinical Center for Paranasal Sinus Disease

Search CenterWatch for Paranasal Sinus Disease

Genetic Tests for Paranasal Sinus Disease

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Anatomical Context for Paranasal Sinus Disease

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34MalaCards
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MalaCards organs/tissues related to Paranasal Sinus Disease:

34
Eye, Bone, Thyroid, T cells

Animal Models for Paranasal Sinus Disease or affiliated genes

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Sources:
38MGI
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Publications for Paranasal Sinus Disease

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53PubMed
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Articles related to Paranasal Sinus Disease:

(show all 43)
idTitleAuthorsYear
1
A stereological study on the correlation of inferior turbinate hypertrophy and paranasal sinus disease. (24389985)
2014
2
The impact of a patient's age on the clinical presentation of inflammatory paranasal sinus disease. (23702318)
2013
3
Prognosis for sixth nerve palsy arising from paranasal sinus disease. (24119609)
2013
4
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): treatments and long-term results of treatments. (21812808)
2012
5
Ophthalmic manifestations of paranasal sinus disease: a clinical grading system. (22411699)
2012
6
Clinical consensus statement: appropriate use of computed tomography for paranasal sinus disease. (23054429)
2012
7
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): ancillary diagnostic findings and involvement of the various sinus compartments. (21812807)
2012
8
Paranasal sinus disease in horses. (21870345)
2011
9
Complications of nose and paranasal sinus disease. (23272436)
2011
10
The expression of fibrinolytic components in chronic paranasal sinus disease. (21711960)
2011
11
Thyroid Eye Disease and Paranasal Sinus Disease. (20924307)
2010
12
T-cell regulation in chronic paranasal sinus disease. (18423831)
2008
13
Significance of blood-tinged post-nasal drip in paranasal sinus disease. (17888198)
2008
14
The incidence of concha bullosa and its relationship to nasal septal deviation and paranasal sinus disease. (15502150)
2004
15
Headaches due to nasal and paranasal sinus disease. (15062525)
2004
16
The role of leukotriene inhibitors in patients with paranasal sinus disease. (12923360)
2003
17
CT characterization of inflammatory paranasal sinus disease in cystic fibrosis. (11972457)
2002
18
Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. (11195032)
2000
19
Use of standard radiography to diagnose paranasal sinus disease of asthmatic children in Taiwan: comparison with computed tomography. (10466541)
1999
20
Optic nerve blindness due to paranasal sinus disease. (10420111)
1999
21
Cytokines and chemokines in paranasal sinus diseases]. (10535064)
1999
22
Relative value of MR imaging as compared with CT in the diagnosis of inflammatory paranasal sinus disease. (9885603)
1999
23
Imaging of paranasal sinus disease. (9168874)
1997
24
Imaging in paranasal sinus disease. (9619203)
1997
25
Correlation of clinical examination with computer tomography in paranasal sinus disease. (9209590)
1997
26
Malignant plasmacytoma appearing as invasive paranasal sinus disease after cardiac transplantation. (8883660)
1996
27
Paranasal sinus disease in patients with cystic fibrosis. (8834282)
1996
28
Efficacy of systemic corticosteroid treatment for anosmia with nasal and paranasal sinus disease. (8560170)
1995
29
Nasal and paranasal sinus disease in patients with congenital velopharyngeal insufficiency. (8049050)
1994
30
Effect of a topical vasoconstrictor on computed tomography of paranasal sinus disease. (8421421)
1993
31
Endoscopic examination and treatment of paranasal sinus disease in 16 horses. (8116208)
1993
32
Inflammatory paranasal sinus disease in Bell's palsy demonstrated by magnetic resonance imaging. (8372929)
1993
33
Paranasal sinus disease in HIV antibody positive patients. (8335314)
1993
34
The prevalence of paranasal sinus disease in HIV infection and AIDS on cranial MR imaging. (8472478)
1993
35
Limited-slice CT in the evaluation of paranasal sinus disease in children. (1898816)
1991
36
Paranasal sinus disease with intracranial extension: aspergillosis versus malignancy. (3131605)
1988
37
Computed tomography in nasal and paranasal sinus disease. (6482629)
1984
38
Comparison between transillumination and the roentgenogram in diagnosing paranasal sinus disease. (7451769)
1981
39
Enzyme therapy in the triad of paranasal sinus disease, allergic asthmatic bronchitis, and bronchiectasis. (14446650)
1959
40
The changing years: their impact upon the management of paranasal sinus disease. (13647565)
1958
41
The changing years: their impact upon the management of paranasal sinus disease. (13583895)
1958
42
Chronic paranasal sinus disease in adults; factors influencing treatment. (18124358)
1949
43
Modern trends in diagnosis and treatment of paranasal sinus disease with particular reference to allergic manifestations. (20261616)
1947

Variations for Paranasal Sinus Disease

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Expression for genes affiliated with Paranasal Sinus Disease

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paranasal Sinus Disease

Search GEO for disease gene expression data for Paranasal Sinus Disease.

Pathways for genes affiliated with Paranasal Sinus Disease

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Sources:
51PathCards, 55R&D Systems, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 5Cell Signaling Technology, 56Reactome, 61Thomson Reuters, 13EMD Millipore
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Pathways related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL27-mediated signaling events39
9.6IFNG, IL17A
2
Show member pathways
9.6IFNG, IL17A
39.6IL17A, IFNG
49.5PLAU, PLAUR
59.5PLAU, PLAUR
69.5PLAUR, PLAU
79.4ALOX5, IL5
89.4IFNG, PLAU
9
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.3IFNG, IL5
109.3IFNG, IL5
119.3IFNG, IL5
129.3IL5, IFNG
139.3IL5, IFNG
149.3IL5, IFNG
159.2PLAUR, SERPINE1
169.1PLAU, SERPINE1
17
Show member pathways
9.1SERPINE1, PLAU
189.1SERPINE1, IFNG
199.0IL5, SERPINE1
20
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.0IL17A, IL5, IFNG
21
Show member pathways
thioredoxin pathway39
8.7ALOX5, IFNG, SERPINE1
22
Show member pathways
8.7SERPINE1, PLAUR, PLAU
23
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
8.7PLAU, PLAUR, SERPINE1
24
Show member pathways
8.7PLAU, PLAUR, SERPINE1
258.7PLAU, PLAUR, SERPINE1
26
Show member pathways
8.7PLAU, PLAUR, SERPINE1
27
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
8.7SERPINE1, PLAUR, PLAU
288.6SERPINE1, IFNG, PLAU
29
Show member pathways
8.5ALOX5, IL17A, IL5, IFNG
30
Show member pathways
8.5ALOX5, IL17A, IL5, IFNG

Compounds for genes affiliated with Paranasal Sinus Disease

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Sources:
46Novoseek, 25HMDB, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 3BitterDB
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Compounds related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1aa861469.4ALOX5, IL5
2notoginsenoside r1469.4PLAU, SERPINE1
35-oxoete469.4ALOX5, PLAUR, IL5
4saporin469.4PLAUR, PLAU
5nickel46 2510.4IL5, PLAUR, IL17A
6nickel subsulfide469.3PLAU, SERPINE1
7n-formylmethionyl-leucylphenylalanine469.3IL5, ALOX5, PLAUR
8rolipram46 62 3011.3IFNG, IL5, ALOX5
9glucosamine46 25 1211.2PLAUR, IL5, IFNG
10curcumin469.1PLAU, IL17A, ALOX5, PLAUR
11eaca469.1PLAUR, SERPINE1, PLAU
12p-amino benzamidine469.1PLAU, PLAUR, SERPINE1
13tranexamic acid46 1210.1PLAU, PLAUR, SERPINE1
14epsilon aminocaproic acid469.1PLAUR, SERPINE1, PLAU
15diisopropylfluorophosphate469.1SERPINE1, PLAU, PLAUR
16cerivastatin52 46 30 1212.0SERPINE1, PLAU, PLAUR
17hirudin469.0PLAU, SERPINE1, PLAUR
18calcitriol46 62 25 1212.0IFNG, ALOX5, PLAU, PLAUR
19kininogen468.9PLAU, PLAUR, SERPINE1
20hydrocortisone46 3 62 1211.9PLAU, IL5, IFNG
21sp 60012546 629.9IL17A, SERPINE1, PLAU
22dmso468.9PLAUR, PLAU, ALOX5, IL5
23aprotinin46 129.9PLAUR, SERPINE1, PLAU
2415-deoxy-delta-12,14-prostaglandin j2468.8PLAU, IFNG, SERPINE1
25histamine46 30 2510.7ALOX5, PLAU, IL5, IFNG
26endotoxin468.7IL17A, IFNG, PLAUR, SERPINE1
27butyrate468.7IFNG, PLAU, PLAUR, IL5
28tgf beta1468.7PLAUR, PLAU, SERPINE1
29thapsigargin46 629.7PLAU, PLAUR, ALOX5, SERPINE1
30aspirin46 52 30 2511.6PLAU, SERPINE1, ALOX5, PLAUR
31pd 98,059468.6IL17A, SERPINE1, PLAUR, PLAU
32vitamin d468.5IL5, PLAUR, ALOX5, SERPINE1
33creatinine468.5PLAU, PLAUR, SERPINE1, IL17A
34thymidine46 259.4IL17A, PLAUR, IFNG, PLAU, IL5
35ly294002468.4IL5, SERPINE1, IL17A, PLAU
36herbimycin a46 629.4IL5, PLAUR, ALOX5, IFNG, PLAU
37arginine468.3PLAU, ALOX5, IL5, PLAUR, IFNG
38actinomycin d468.2PLAUR, SERPINE1, PLAU, IFNG, IL17A
39estrogen468.2ALOX5, PLAU, PLAUR, IL17A, SERPINE1
40h2o2468.2ALOX5, PLAU, PLAUR, IL5
41tacrolimus46 52 1210.2ALOX5, IL17A, IL5, IFNG, SERPINE1
42heparin46 30 25 1211.1IL5, ALOX5, SERPINE1, PLAUR, PLAU
43indomethacin46 30 62 1211.0PLAU, IFNG, PLAUR, IL17A, ALOX5, IL5
44pge2468.0ALOX5, IFNG, IL5, IL17A, PLAUR, PLAU
45retinoic acid46 258.8PLAU, SERPINE1, IFNG, PLAUR, IL5
46dexamethasone46 52 30 1210.7SERPINE1, IFNG, IL5, IL17A, PLAUR, ALOX5
47genistein46 30 62 3 25 1212.6ALOX5, PLAUR, IFNG, SERPINE1, PLAU, IL5
48cycloheximide467.6SERPINE1, ALOX5, IFNG, IL5, PLAUR, PLAU
49sb 20358046 628.2IL5, ALOX5, PLAU, PLAUR, IL17A, IFNG
50vegf467.2ALOX5, PLAU, PLAUR, IL17A, SERPINE1, IL5

GO Terms for genes affiliated with Paranasal Sinus Disease

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17Gene Ontology
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Cellular components related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5PLAU, PLAUR, IL5, IFNG, SERPINE1
2extracellular spaceGO:0056156.9ALOX5, SERPINE1, IFNG, IL5, IL17A, PLAU

Biological processes related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-23 productionGO:0327479.7IL17A, IFNG
2positive regulation of osteoclast differentiationGO:0456729.6IFNG, IL17A
3cellular component movementGO:0069289.5PLAUR, IFNG
4regulation of receptor activityGO:0104699.2PLAU, SERPINE1
5cellular response to lipopolysaccharideGO:0712228.8IFNG, SERPINE1
6fibrinolysisGO:0427308.8PLAU, PLAUR, SERPINE1
7blood coagulationGO:0075968.6PLAU, PLAUR, SERPINE1

Molecular functions related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL17A, IL5, IFNG

Products for genes affiliated with Paranasal Sinus Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Paranasal Sinus Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet