Paranasal Sinus Disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Paranasal Sinus Disease

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⁶³Wikipedia, ³²MalaCards
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Wikipedia:⁶³ Paranasal sinuses are a group of four paired air-filled spaces that surround the nasal cavity (maxillary... more...

MalaCards: Paranasal Sinus Disease, also known as paranasal sinus disorder, is related to cystic fibrosis and aspergillosis. An important gene associated with Paranasal Sinus Disease is IL17A (interleukin 17A), and among its related pathways are Senescence and Autophagy and PEDF Induced Signaling. The compounds pge2 and nickel have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and thyroid, and related mouse phenotypes are respiratory system and tumorigenesis.

Aliases & Classifications for Paranasal Sinus Disease

Sources:
⁸Disease Ontology, ⁶⁰UMLS, ⁵⁶SNOMED-CT, ³⁹NCIt, ³⁴MeSH
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Aliases & Descriptions:

paranasal sinus disease ⁸

paranasal sinus disorder ⁸

paranasal sinus diseases ⁶⁰

disorder of nasal sinus ⁸

External Ids:

Disease Ontology⁸ DOID:1352

NCIt³⁹ C26843

SNOMED-CT⁵⁶ 7393007

MeSH³⁴ D010254

UMLS⁶⁰ C0030469

Related Diseases for Paranasal Sinus Disease

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Paranasal Sinus Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 124)

id	Related Disease	Score	Top Affiliating Genes
1	cystic fibrosis	30.4	IL17A
2	aspergillosis	30.1	IFNG
3	bronchitis	30.1	IL17A, ALOX5
4	eosinophilia	30.1	IL5, IFNG, ALOX5
5	asthma	30.1	IL5, IFNG, IL17A, PLAUR, ALOX5
6	nose disease	10.3
7	bell's palsy	10.1
8	bronchiectasis	10.1
9	eye disease	10.1
10	optic nerve disease	10.1
11	plasmacytoma	10.1
12	thyroiditis	10.1
13	gingivitis	10.0	IL17A
14	infertility	10.0	IL17A
15	gastritis	10.0	IL17A
16	nephrotic syndrome	10.0	IL17A
17	encephalitis	10.0	IL17A
18	cervical cancer	10.0	IL17A
19	cholera	10.0	IL17A
20	rhinitis	10.0	IL5
21	bladder carcinoma	10.0	PLAUR
22	esophagitis	10.0	IL5
23	polymyositis	10.0	IL17A
24	hypersensitivity reaction type ii disease	10.0	IL17A
25	diphtheria	10.0	PLAUR
26	churg-strauss syndrome	10.0	IL5
27	dermatomyositis	10.0	IL17A
28	bronchiolitis	10.0	IL5
29	eosinophilic fasciitis	10.0	IL5
30	pleurisy	10.0	ALOX5
31	peritonitis	10.0	ALOX5
32	glomerulonephritis	10.0	ALOX5
33	mycosis fungoides	10.0	IL5
34	eosinophilia-myalgia syndrome	10.0	IL5
35	vascular disease	10.0	PLAU
36	lung cancer	10.0	PLAU
37	thrombocytopenia	10.0	ALOX5
38	strongyloidiasis	10.0	IL5
39	myocardial infarction	10.0	SERPINE1
40	aids dementia complex	10.0	PLAUR
41	pulmonary eosinophilia	10.0	IL5
42	omenn syndrome	10.0	IL5
43	meningioma	10.0	ALOX5
44	polycystic ovary syndrome	10.0	SERPINE1
45	acute myocardial infarction	10.0	SERPINE1
46	eosinophilic esophagitis	10.0	IL5
47	arteriosclerosis	10.0	SERPINE1
48	onchocerciasis	10.0	IL5
49	nephritis	10.0	IL17A
50	hypertension	10.0	SERPINE1

Graphical network of the top 20 diseases related to Paranasal Sinus Disease:

Clinical Features for Paranasal Sinus Disease

Drugs & Therapeutics for Paranasal Sinus Disease

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Approved drugs:

Search CenterWatch for Paranasal Sinus Disease

Drug clinical trials:

Search ClinicalTrials for Paranasal Sinus Disease

Search NIH Clinical Center for Paranasal Sinus Disease

Search CenterWatch for Paranasal Sinus Disease

Genetic Tests for Paranasal Sinus Disease

Anatomical Context for Paranasal Sinus Disease

Sources:
³²MalaCards
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MalaCards organs/tissues related to Paranasal Sinus Disease:

³²

Eye, Bone, Thyroid, T cells

Animal Models for Paranasal Sinus Disease or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Paranasal Sinus Disease:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.7	PLAUR, PLAU
2	tumorigenesis	MP:0002006	9.2	IL5, IFNG
3	digestive/alimentary phenotype	MP:0005381	8.3	PLAU, IL17A, IL5, IFNG
4	homeostasis/metabolism phenotype	MP:0005376	8.2	ALOX5, SERPINE1, IL5, IFNG
5	renal/urinary system phenotype	MP:0005367	7.9	IFNG, IL17A, PLAUR, SERPINE1
6	liver/biliary system phenotype	MP:0005370	7.7	IFNG, IL5, PLAU, PLAUR, SERPINE1
7	cardiovascular system phenotype	MP:0005385	7.5	IFNG, PLAU, PLAUR, SERPINE1, ALOX5
8	hematopoietic system phenotype	MP:0005397	6.9	ALOX5, IFNG, IL5, IL17A, PLAU, PLAUR
9	immune system phenotype	MP:0005387	6.9	IFNG, IL5, IL17A, PLAU, PLAUR, SERPINE1

Publications for Paranasal Sinus Disease

Sources:
⁵⁰PubMed
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Articles related to Paranasal Sinus Disease:

(show all 49)

id	Title	Authors	Year
1	A stereological study on the correlation of inferior turbinate hypertrophy and paranasal sinus disease. (24389985)	Ural A.... Candan H.	2014
2	The impact of a patient's age on the clinical presentation of inflammatory paranasal sinus disease. (23702318)	Busaba N.Y.	2013
3	Immunoglobulin G4-related sclerosing disease of the paranasal sinus. (23047661)	Lindau R.H.... Smith R.B.	2013
4	Prognosis for sixth nerve palsy arising from paranasal sinus disease. (24119609)	Miller C.... Chiu A.G.	2013
5	Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): treatments and long-term results of treatments. (21812808)	Dixon P.M.... Barakzai S.Z.	2012
6	Ophthalmic manifestations of paranasal sinus disease: a clinical grading system. (22411699)	Al Anazy F.H.... Al Dousary S.H.	2012
7	Clinical consensus statement: appropriate use of computed tomography for paranasal sinus disease. (23054429)	Setzen G.... Patel M.M.	2012
8	Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): ancillary diagnostic findings and involvement of the various sinus compartments. (21812807)	Dixon P.M.... Barakzai S.Z.	2012
9	Ophthalmic complications following treatment of paranasal sinus rhabdomyosarcoma in comparison to orbital disease. (21242849)	Gandhi P.D.... Wilson M.W.	2011
10	Paranasal sinus disease in horses. (21870345)	Waguespack R.W.... Taintor J.	2011
11	Complications of nose and paranasal sinus disease. (23272436)	Sajid T.... Khan J.	2011
12	The expression of fibrinolytic components in chronic paranasal sinus disease. (21711960)	Sejima T.... Bachert C.	2011
13	Thyroid Eye Disease and Paranasal Sinus Disease. (20924307)	Wiwanitkit V.	2010
14	Paranasal sinus disease and sputum eosinophilia in prednisone-dependent asthma. (21144367)	Lui B.T.... Nair P.	2010
15	T-cell regulation in chronic paranasal sinus disease. (18423831)	Van Bruaene N.... Gevaert P.	2008
16	Significance of blood-tinged post-nasal drip in paranasal sinus disease. (17888198)	Chao T.K.... Huang W.H.	2008
17	Total IgE levels and peripheral eosinophilia: correlation with mucosal disease based on computed tomographic imaging of the paranasal sinus. (17638784)	Poznanovic S.A.... Kingdom T.T.	2007
18	Nasal and paranasal sinus manifestation of Rosai-Dorfman disease. (16218519)	Hagemann M.... Caversaccio M.	2005
19	Extranodal Rosai-Dorfman disease of bone, subcutaneous tissue and paranasal sinus mucosa with a review of its pathogenesis. (16096753)	Yoon A.J.... Young-In Lee F.	2005
20	The incidence of concha bullosa and its relationship to nasal septal deviation and paranasal sinus disease. (15502150)	Stallman J.S.... Som P.M.	2004
21	Headaches due to nasal and paranasal sinus disease. (15062525)	Silberstein S.D.	2004
22	The role of leukotriene inhibitors in patients with paranasal sinus disease. (12923360)	Parnes S.M.	2003
23	CT characterization of inflammatory paranasal sinus disease in cystic fibrosis. (11972457)	EggesbA... Kolmannskog F.	2002
24	Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. (11195032)	Bachmann G.... Michel O.	2000
25	Use of standard radiography to diagnose paranasal sinus disease of asthmatic children in Taiwan: comparison with computed tomography. (10466541)	Chen L.C.... Lin S.J.	1999
26	Optic nerve blindness due to paranasal sinus disease. (10420111)	Fujimoto N.... Nagata H.	1999
27	Cytokines and chemokines in paranasal sinus diseases]. (10535064)	Rudack C.... Bachert C.	1999
28	Relative value of MR imaging as compared with CT in the diagnosis of inflammatory paranasal sinus disease. (9885603)	HAohnel S.... Jansen O.	1999
29	Imaging of paranasal sinus disease. (9168874)	Bangert B.A.	1997
30	Imaging in paranasal sinus disease. (9619203)	Teh J.... Smith A.	1997
31	Correlation of clinical examination with computer tomography in paranasal sinus disease. (9209590)	Casiano R.R.	1997
32	Malignant plasmacytoma appearing as invasive paranasal sinus disease after cardiac transplantation. (8883660)	Kramer G.S.... Gatenby R.A.	1996
33	Paranasal sinus disease in patients with cystic fibrosis. (8834282)	Nishioka G.J.... Cook P.R.	1996
34	Efficacy of systemic corticosteroid treatment for anosmia with nasal and paranasal sinus disease. (8560170)	Ikeda K.... Takasaka T.	1995
35	Nasal and paranasal sinus disease in patients with congenital velopharyngeal insufficiency. (8049050)	Ishikawa Y.... Amitani R.	1994
36	Effect of a topical vasoconstrictor on computed tomography of paranasal sinus disease. (8421421)	Stringer S.P.... Avino A.J.	1993
37	Endoscopic examination and treatment of paranasal sinus disease in 16 horses. (8116208)	Ruggles A.J.... Freeman D.E.	1993
38	Inflammatory paranasal sinus disease in Bell's palsy demonstrated by magnetic resonance imaging. (8372929)	Stenquist M.... Jonsson L.	1993
39	Paranasal sinus disease in HIV antibody positive patients. (8335314)	Grant A.... Miller R.F.	1993
40	The prevalence of paranasal sinus disease in HIV infection and AIDS on cranial MR imaging. (8472478)	Chong W.K.... Harrison M.J.	1993
41	Limited-slice CT in the evaluation of paranasal sinus disease in children. (1898816)	Gross G.W.... Ehrlich S.M.	1991
42	Paranasal sinus disease with intracranial extension: aspergillosis versus malignancy. (3131605)	Sarti E.J.... Camins M.B.	1988
43	Computed tomography in nasal and paranasal sinus disease. (6482629)	Unger J.M.... Duncavage J.A.	1984
44	Comparison between transillumination and the roentgenogram in diagnosing paranasal sinus disease. (7451769)	Spector S.L.... Philpot I.	1981
45	Enzyme therapy in the triad of paranasal sinus disease, allergic asthmatic bronchitis, and bronchiectasis. (14446650)	SILBERT N.E.	1959
46	The changing years: their impact upon the management of paranasal sinus disease. (13647565)	HILL F.T.	1958
47	The changing years: their impact upon the management of paranasal sinus disease. (13583895)	HILL F.T.	1958
48	Chronic paranasal sinus disease in adults; factors influencing treatment. (18124358)	Gill J.P.	1949
49	Modern trends in diagnosis and treatment of paranasal sinus disease with particular reference to allergic manifestations. (20261616)	GILL E.K.	1947

Genes related to Paranasal Sinus Disease

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Paranasal Sinus Disease:

id	Symbol	Description	Score	Implication
1	IL17A	interleukin 17A	21.47	GeneCards inferred : Publications, Disorders (show sections)
2	PLAUR	plasminogen activator, urokinase receptor	18.61	GeneCards inferred : Publications, Disorders (show sections)
3	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	15.75	GeneCards inferred : Publications, Disorders (show sections)
4	PLAU	plasminogen activator, urokinase	12.89	GeneCards inferred : Publications, Disorders (show sections)
5	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	10.04	GeneCards inferred : Publications, Disorders (show sections)
6	IFNG	interferon, gamma	7.18	GeneCards inferred : Publications, Disorders (show sections)
7	ALOX5	arachidonate 5-lipoxygenase	2.83	GeneCards inferred : Publications (show sections)

Products for genes related to Paranasal Sinus Disease disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	7	7	7
2	LSBio	-	-	7

Genetic Variations for Paranasal Sinus Disease

Expression for genes affiliated with Paranasal Sinus Disease

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paranasal Sinus Disease

Search GEO for disease gene expression data for Paranasal Sinus Disease.

Pathways for genes affiliated with Paranasal Sinus Disease

Sources:
³⁷NCBI BioSystems Database, ⁵¹QIAGEN, ²⁹KEGG, ⁵³Reactome, ⁵²R&D Systems, ¹²EMD Millipore
See all sources

Pathways related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show all 20)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Senescence and Autophagy³⁷	9.9	SERPINE1
2	PEDF Induced Signaling⁵¹ Hide members Cytokine-cytokine receptor interaction²⁹ all-trans-Retinoic Acid Signaling in Brain⁵¹ NFAT Signaling and Lymphocyte Interactions⁵¹ STAT3 Pathway⁵¹ RAR-Gamma-RXR-Alpha Degradation⁵¹ PGC1Alpha Pathway⁵¹ Glucocorticoid Receptor Signaling⁵¹ IL-6 Pathway⁵¹ Endothelin-1 Signaling Pathway⁵¹ MIF Regulation of Innate Immune Cells⁵¹ MIF Mediated Glucocorticoid Regulation⁵¹	9.6	IL5, IL17A
3	Validated transcriptional targets of AP1 family members Fra1 and Fra2³⁷	9.5	PLAUR, PLAU
4	FGF signaling pathway³⁷	9.5	PLAUR, PLAU
5	amb2 Integrin signaling³⁷	9.5	PLAUR, PLAU
6	Formation of Fibrin Clot (Clotting Cascade)⁵³ Hide members Blood Clotting Cascade³⁷ Blood Coagulation Signaling Pathways⁵²	9.3	PLAU, SERPINE1
7	IL27-mediated signaling events³⁷ Hide members Th1 Differentiation⁵²	9.3	IL17A, IFNG
8	Cytokine Network⁵¹	9.2	IFNG, IL5
9	Calcium signaling in the CD4+ TCR pathway³⁷ Hide members Calcineurin-regulated NFAT-dependent transcription in lymphocytes³⁷	9.2	IFNG, IL5
10	Inflammatory Response Pathway³⁷	9.2	IL5, IFNG
11	OX40 Pathway⁵¹	9.2	IL5, IFNG
12	ATF-2 transcription factor network³⁷	9.1	PLAU, IFNG
13	Platelet activation, signaling and aggregation⁵³ Hide members Hemostasis⁵³	8.9	PLAU, PLAUR, SERPINE1
14	Complement and coagulation cascades²⁹ Hide members Complement and Coagulation Cascades³⁷	8.9	SERPINE1, PLAUR, PLAU
15	Dissolution of Fibrin Clot⁵³	8.9	SERPINE1, PLAUR, PLAU
16	Cell adhesion ECM remodeling Hide members Cell adhesion ECM remodeling¹²	8.9	SERPINE1, PLAUR, PLAU
17	Translation Insulin regulation of translation Hide members Cell adhesion PLAU signaling¹²	8.9	SERPINE1, PLAUR, PLAU
18	B cell receptor signaling pathway²⁹ Hide members TCR Signaling Pathway³⁷ T cell receptor signaling pathway²⁹	8.8	IL17A, IL5, IFNG
19	Selenium Pathway³⁷	8.5	IFNG, SERPINE1, ALOX5
20	Leishmaniasis²⁹ Hide members Toxoplasmosis²⁹ Inflammatory bowel disease (IBD)²⁹	8.3	IFNG, IL5, IL17A, ALOX5

Compounds for genes affiliated with Paranasal Sinus Disease

Sources:
⁴⁴Novoseek, ²⁴HMDB, ²⁸IUPHAR, ¹¹DrugBank, ⁵⁹Tocris Bioscience, ²BitterDB, ⁴⁹PharmGKB
See all sources

Compounds related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show top 50) (show all 108)

id	Compound	Score	Top Affiliating Genes
1	pge2⁴⁴	10.4	PLAU
2	nickel⁴⁴ ²⁴	11.4	IL5
3	heparin⁴⁴ ²⁸ ¹¹ ²⁴	13.4	ALOX5
4	butyrate⁴⁴	10.4	IL5
5	rolipram⁴⁴ ⁵⁹ ²⁸	12.3	ALOX5
6	hydrocortisone⁴⁴ ² ⁵⁹ ¹¹	13.0	PLAU
7	endotoxin⁴⁴	9.8	PLAUR, SERPINE1
8	Reteplase¹¹	9.7	PLAUR, SERPINE1
9	Anistreplase¹¹	9.7	SERPINE1, PLAUR
10	Alteplase¹¹	9.7	SERPINE1, PLAUR
11	notoginsenoside r1⁴⁴	9.7	SERPINE1, PLAU
12	nickel subsulfide⁴⁴	9.6	PLAU, SERPINE1
13	dexamethasone⁴⁴ ⁴⁹ ²⁸ ¹¹	12.5	ALOX5, IL5, PLAUR
14	5-oxoete⁴⁴	9.5	IL5, PLAUR, ALOX5
15	aa861⁴⁴	9.5	IL5, ALOX5
16	n-formylmethionyl-leucylphenylalanine⁴⁴	9.4	PLAUR, ALOX5, IL5
17	eaca⁴⁴	9.4	PLAU, SERPINE1, PLAUR
18	p-amino benzamidine⁴⁴	9.4	PLAU, PLAUR, SERPINE1
19	Urokinase¹¹	9.3	PLAU, PLAUR, SERPINE1
20	tranexamic acid⁴⁴ ¹¹	10.3	PLAU, SERPINE1, PLAUR
21	epsilon aminocaproic acid⁴⁴	9.3	PLAUR, PLAU, SERPINE1
22	thapsigargin⁴⁴ ⁵⁹	10.3	SERPINE1, PLAU, PLAUR
23	diisopropylfluorophosphate⁴⁴	9.3	SERPINE1, PLAU, PLAUR
24	cerivastatin⁴⁴ ⁴⁹ ²⁸ ¹¹	12.3	PLAUR, SERPINE1, PLAU
25	hirudin⁴⁴	9.3	PLAUR, PLAU, SERPINE1
26	saporin⁴⁴	9.2	PLAU, PLAUR
27	kininogen⁴⁴	9.2	SERPINE1, PLAU, PLAUR
28	glucosamine⁴⁴ ¹¹ ²⁴	11.1	IFNG, IL5, PLAUR
29	creatinine⁴⁴	9.1	PLAUR, PLAU, IL17A
30	curcumin⁴⁴	9.0	PLAUR, PLAU, IL17A, ALOX5
31	aprotinin⁴⁴ ¹¹	10.0	SERPINE1, PLAU, PLAUR
32	sp 600125⁴⁴ ⁵⁹	10.0	PLAU, SERPINE1, IL17A
33	dmso⁴⁴	9.0	PLAUR, ALOX5, PLAU, IL5
34	vitamin d⁴⁴	8.8	PLAUR, SERPINE1, IL5, ALOX5
35	aspirin⁴⁴ ⁴⁹ ²⁸ ²⁴	11.8	PLAUR, ALOX5, SERPINE1, PLAU
36	pd 98,059⁴⁴	8.8	SERPINE1, PLAUR, PLAU, IL17A
37	ly294002⁴⁴	8.7	SERPINE1, IL17A, PLAU, IL5
38	15-deoxy-delta-12,14-prostaglandin j2⁴⁴	8.7	PLAU, IFNG, SERPINE1
39	calcitriol⁴⁴ ⁵⁹ ¹¹ ²⁴	11.6	ALOX5, PLAU, PLAUR, IFNG
40	histamine⁴⁴ ²⁸ ²⁴	10.4	IFNG, ALOX5, IL5, PLAU
41	thymidine⁴⁴ ²⁴	9.3	PLAUR, PLAU, IL17A, IFNG, IL5
42	herbimycin a⁴⁴ ⁵⁹	9.2	ALOX5, IFNG, IL5, PLAU, PLAUR
43	actinomycin d⁴⁴	8.1	PLAUR, IL17A, IFNG, PLAU, SERPINE1
44	tacrolimus⁴⁴ ⁴⁹ ¹¹	10.1	IFNG, IL17A, SERPINE1, IL5, ALOX5
45	arginine⁴⁴	8.1	IFNG, IL5, PLAU, PLAUR, ALOX5
46	indomethacin⁴⁴ ⁵⁹ ²⁸ ¹¹	10.8	IL5, IL17A, PLAU, PLAUR, IFNG, ALOX5
47	retinoic acid⁴⁴ ²⁴	8.8	PLAUR, IFNG, IL5, PLAU, SERPINE1
48	genistein⁴⁴ ²⁸ ⁵⁹ ² ¹¹ ²⁴	12.6	IFNG, IL5, PLAU, PLAUR, SERPINE1, ALOX5
49	sb 203580⁴⁴ ⁵⁹	8.2	ALOX5, PLAUR, PLAU, IL17A, IL5, IFNG
50	vegf⁴⁴	7.2	PLAU, SERPINE1, ALOX5, PLAUR, IFNG, IL5

GO Terms for genes affiliated with Paranasal Sinus Disease

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	7.6	IL5, PLAU, PLAUR, SERPINE1, IFNG
2	extracellular space	GO:005615	7.4	SERPINE1, PLAU, IL17A, IL5, IFNG

Biological processes related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of osteoclast differentiation	GO:045672	9.3	IL17A, IFNG
2	positive regulation of interleukin-23 production	GO:032747	9.2	IL17A, IFNG
3	regulation of receptor activity	GO:010469	9.0	SERPINE1, PLAU
4	fibrinolysis	GO:042730	8.9	SERPINE1, PLAUR, PLAU