Paranasal Sinus Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PRN021 MIFTS: 51	Paranasal Sinus Disease Categories: Respiratory diseases
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Aliases & Classifications for Paranasal Sinus Disease

MalaCards integrated aliases for Paranasal Sinus Disease:

Name: Paranasal Sinus Disease ¹² ¹⁴

Paranasal Sinus Diseases ⁴¹ ⁶⁹

Disorder of Nasal Sinus ¹²

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1352

MeSH ⁴¹ D010254

NCIt ⁴⁶ C26843

SNOMED-CT ⁶⁴ 195823002 7393007

UMLS ⁶⁹ C0030469

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Summaries for Paranasal Sinus Disease

MalaCards based summary : Paranasal Sinus Disease, also known as paranasal sinus diseases, is related to aging and aspergillosis. An important gene associated with Paranasal Sinus Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Amoxicillin and Cefditoren have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and lung, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : ⁷² Paranasal sinuses are a group of four paired air-filled spaces that surround the nasal cavity. The... more...

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Related Diseases for Paranasal Sinus Disease

Diseases related to Paranasal Sinus Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)

#	Related Disease	Score	Top Affiliating Genes
1	aging	29.6	IL10 SERPINE1 TGFB1
2	aspergillosis	29.5	CD79A IFNG IL10 IL4 IL5
3	asthma	28.2	ALOX5 CD79A GATA3 IFNG IL10 IL13
4	cytokine deficiency	10.6	IL13 IL5
5	mycoplasmal pneumonia	10.6	IFNG IL4
6	eosinophilic fasciitis	10.6	IFNG IL5
7	tropical endomyocardial fibrosis	10.5	IL10 IL4
8	angioimmunoblastic lymphadenopathy with dysproteinemia	10.5	IL13 IL5
9	ascaridiasis	10.5	IL10 IL13
10	respiratory syncytial virus infectious disease	10.5	IL13 IL5
11	tungiasis	10.5	IL10 IL4
12	b-cell growth factor	10.5	IFNG IL4
13	endomyocardial fibrosis	10.5	IL10 IL4
14	african tick-bite fever	10.5	IFNG IL13
15	cough variant asthma	10.5	IL4 IL5
16	paragonimiasis	10.5	IL13 IL5
17	inflammatory bowel disease 4	10.5	IL13 IL4 IL5
18	latex allergy	10.5	IL13 IL4 IL5
19	atopic keratoconjunctivitis	10.5	IFNG IL4 IL5
20	intestinal schistosomiasis	10.5	IL13 IL4 IL5
21	chronic conjunctivitis	10.5	IL13 IL4 IL5
22	eosinophilic gastritis	10.5	IL13 IL4 IL5
23	chronic tic disorder	10.5	IL13 IL4 IL5
24	vernal keratoconjunctivitis	10.5	IL13 IL4 IL5
25	penicillin allergy	10.4	IFNG IL13 IL4
26	folliculitis	10.4	IFNG IL4 IL5
27	toxic oil syndrome	10.4	IFNG IL4 IL5
28	hyperlucent lung	10.4	IFNG IL10 IL4
29	pulmonary eosinophilia	10.4	IL13 IL4 IL5
30	necatoriasis	10.4	IL10 IL5
31	onchocerciasis	10.4	IL13 IL4 IL5
32	beta-lactam allergy	10.4	IL10 IL13 IL4
33	baylisascariasis	10.4	IFNG IL10 IL4
34	neurosyphilis	10.4	IL10 IL17A
35	leukocyte disease	10.4	IL13 IL4 IL5
36	multicentric castleman disease	10.4	IFNG IL10 IL5
37	buruli ulcer	10.4	IFNG IL10 IL4
38	perforated corneal ulcer	10.4	PLAU PLAUR
39	poliomyelitis	10.4	IFNG IL10 IL4
40	eales disease	10.4	IFNG IL10 IL4
41	peanut allergy	10.4	IFNG IL10 IL13
42	trichosporonosis	10.4	IFNG IL17A
43	sezary's disease	10.4	IFNG IL4 IL5
44	acute graft versus host disease	10.4	IFNG IL10 IL4
45	juvenile myasthenia gravis	10.4	IL10 TGFB1
46	brucellosis	10.4	IFNG IL10 IL4
47	filariasis	10.4	IFNG IL10 IL5
48	retinitis pigmentosa 22	10.4	IL10 IL4
49	immune suppression	10.4	IFNG IL10
50	toxic shock syndrome	10.3	IFNG IL10 IL4

Graphical network of the top 20 diseases related to Paranasal Sinus Disease:

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Symptoms & Phenotypes for Paranasal Sinus Disease

MGI Mouse Phenotypes related to Paranasal Sinus Disease:

⁴³ (show all 19)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.39	TGFB1 GATA3 ALOX5 CD79A IFNG FLNC
2	hematopoietic system	MP:0005397	10.37	TGFB1 ALOX5 CD79A IFNG GATA3 IL10
3	growth/size/body region	MP:0005378	10.35	TGFB1 GATA3 IFNG FLNC IL13 IL10
4	immune system	MP:0005387	10.34	TGFB1 GATA3 ALOX5 CD79A IFNG IL10
5	cellular	MP:0005384	10.32	TGFB1 GATA3 ALOX5 CD79A IFNG IL4
6	cardiovascular system	MP:0005385	10.24	SERPINE1 TGFB1 IFNG GATA3 ALOX5 FLNC
7	digestive/alimentary	MP:0005381	10.21	TGFB1 GATA3 IFNG IL13 IL10 IL17A
8	mortality/aging	MP:0010768	10.17	SERPINE1 TGFB1 IFNG GATA3 FLNC IL13
9	endocrine/exocrine gland	MP:0005379	10.15	TGFB1 IFNG GATA3 IL13 IL17A IL10
10	integument	MP:0010771	10.13	TGFB1 GATA3 IFNG FLNC IL4 IL13
11	craniofacial	MP:0005382	10.11	TGFB1 IFNG GATA3 IL4 IL17A IL10
12	liver/biliary system	MP:0005370	10.11	TGFB1 CD79A IFNG IL10 IL4 PLAU
13	muscle	MP:0005369	10.01	TGFB1 GATA3 FLNC IFNG IL13 IL10
14	neoplasm	MP:0002006	9.91	TGFB1 CD79A IFNG IL10 SERPINE1 PLAU
15	no phenotypic analysis	MP:0003012	9.87	IFNG GATA3 CD79A IL13 IL17A IL10
16	renal/urinary system	MP:0005367	9.86	TGFB1 GATA3 CD79A IFNG IL4 IL17A
17	reproductive system	MP:0005389	9.76	TGFB1 IFNG GATA3 IL13 IL10 IL4
18	respiratory system	MP:0005388	9.73	TGFB1 IFNG FLNC IL10 IL17A IL4
19	skeleton	MP:0005390	9.28	TGFB1 GATA3 ALOX5 IFNG IL4 IL13

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Drugs & Therapeutics for Paranasal Sinus Disease

Drugs for Paranasal Sinus Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 322)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Amoxicillin

Approved, Vet_approved

Phase 4,Phase 3,Phase 2

26787-78-0

33613 2171

Cefditoren

Approved, Investigational

Phase 4

104145-95-1, 117467-28-4

9870843 9571074

Montelukast

Approved

Phase 4

158966-92-8

5281040

Prednisone

Approved, Vet_approved

Phase 4,Phase 3,Phase 1

53-03-2

5865

Epinephrine

Approved, Vet_approved

Phase 4,Phase 3

51-43-4

5816

Racepinephrine

Approved

Phase 4,Phase 3

329-65-7

Azithromycin

Approved

Phase 4,Phase 3,Phase 2

83905-01-5

53477736 447043 55185

Budesonide

Approved

Phase 4,Phase 2,Phase 3,Phase 1

51333-22-3

5281004 63006

Doxycycline

Approved, Investigational, Vet_approved

Phase 4,Phase 2

564-25-0

54671203

Cocaine

Approved, Illicit

Phase 4

50-36-2

446220 5760

Dopamine

Approved

Phase 4,Phase 2

51-61-6, 62-31-7

681

Dexmedetomidine

Approved, Vet_approved

Phase 4

76631-46-4, 113775-47-6

5311068 56032 68602

Propofol

Approved, Investigational, Vet_approved

Phase 4

2078-54-8

4943

Remifentanil

Approved

Phase 4

132875-61-7

60815

Triamcinolone

Approved, Vet_approved

Phase 4,Phase 3

124-94-7

31307

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 2,Phase 3

83-43-2

6741

Prednisolone

Approved, Vet_approved

Phase 4,Phase 2,Phase 3

50-24-8

5755

Estradiol

Approved, Investigational, Vet_approved

Phase 4,Phase 3

50-28-2

5757

Ethinyl Estradiol

Approved

Phase 4,Phase 3

57-63-6

5991

Moxifloxacin

Approved, Investigational

Phase 4,Phase 3

151096-09-2, 354812-41-2

152946

Norgestimate

Approved, Investigational

Phase 4,Phase 3

35189-28-7

6540478

Cefdinir

Approved

Phase 4

91832-40-5

6915944

Levofloxacin

Approved, Investigational

Phase 4,Phase 3

100986-85-4

149096

Ofloxacin

Approved

Phase 4,Phase 3

82419-36-1

4583

Hyaluronic acid

Approved, Vet_approved

Phase 4

9004-61-9

53477741 24759

Acetaminophen

Approved

Phase 4,Phase 2,Phase 3

103-90-2

1983

Dextromethorphan

Approved

Phase 4

125-71-3

5362449 5360696

Ephedrine

Approved

Phase 4,Phase 2

299-42-3

9294

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4,Phase 2

93-14-1

3516

Pseudoephedrine

Approved

Phase 4,Phase 2

90-82-4

7028

Thrombin

Approved, Investigational

Phase 4

Telithromycin

Approved

Phase 4,Phase 3

191114-48-4

0 5462516

Omalizumab

Approved, Investigational

Phase 4,Phase 3,Phase 2

242138-07-4

Omeprazole

Approved, Investigational, Vet_approved

Phase 4

73590-58-6

4594

Almotriptan

Approved, Investigational

Phase 4

154323-57-6, 181183-52-8

123606

Histamine

Approved, Investigational

Phase 4

51-45-6, 75614-87-8

774

Clarithromycin

Approved

Phase 4,Phase 3

81103-11-9

84029

Bacitracin

Approved, Vet_approved

Phase 4,Phase 2

1405-87-4

10909430 439542

Isoflurane

Approved, Vet_approved

Phase 4

26675-46-7

3763

Sevoflurane

Approved, Vet_approved

Phase 4

28523-86-6

5206

Citalopram

Approved

Phase 4

59729-33-8

2771

Strawberry

Approved, Nutraceutical

Phase 4,Phase 3

Amoxicillin-Potassium Clavulanate Combination

Phase 4,Phase 3

Anti-Bacterial Agents

Phase 4,Phase 3,Phase 2,Phase 1

Anti-Infective Agents

Phase 4,Phase 3,Phase 2,Phase 1

beta-Lactamase Inhibitors

Phase 4,Phase 3

Clavulanic Acid

Phase 4,Phase 3

Cefditoren pivoxil

Phase 4

Cephalosporins

Phase 4

Anti-Allergic Agents

Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 354)

#	Name	Status	NCT ID	Phase	Drugs
1	Middle Meatal Bacteriology During Acute Respiratory Infection in Children	Unknown status	NCT00545961	Phase 4	placebo;amoxicillin clavulanate acid
2	Study of Cefditoren Pivoxil in Treatment of Childhood With Acute Rhinosinusitis	Unknown status	NCT01553006	Phase 4	cefditoren pivoxil
3	Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery	Unknown status	NCT02110654	Phase 4	Montelukast;mometasone furoate nasal spray
4	Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis	Completed	NCT00396162	Phase 4	probiotic containing L.rhamnosus R0011 strain
5	The PIO II Study of In-office Placement of a Steroid-eluting Sinus Implant	Completed	NCT02668302	Phase 4
6	Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate	Completed	NCT02340000	Phase 4	standard dose amoxicillin/clavulanate;high dose amoxicillin/clavulanate
7	Azithromycin for Patients With Chronic Rhinosinusitis Failing Medical and Surgical Therapy	Completed	NCT02307825	Phase 4	Azithromycin;Placebo
8	Efficacy and Safety of Sinusitis Hevert SL Tablets Compared to Placebo in Adult Patients With Acute, Uncomplicated Rhinosinusitis	Completed	NCT02296814	Phase 4	Sinusitis Hevert SL Tablet;Placebo for Sinusitis Hevert SL Tablet
9	The Optimal Head Position for Distributing Topical Nasal Medication Using the Mucosal Atomization Device	Completed	NCT02079792	Phase 4
10	Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis	Completed	NCT01825408	Phase 4	Doxycycline;Azithromycin;Augmentin
11	Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery	Completed	NCT01706952	Phase 4	Cocaine;Adrenaline
12	Saline Irrigation After Surgery in Patients With Chronic Sinusitis	Completed	NCT01575223	Phase 4
13	Randomized Controlled Trial to Evaluate of Dexmedetomidine for the Effect on Operative Visibility in Patients Undergoing Endoscopic Sinus Surgery	Completed	NCT01569048	Phase 4	Propofol and dexmedetomidine;propofol and remifentanil
14	Medicated Punctured-Glove-Finger Spacer Study	Completed	NCT01420471	Phase 4	Triamcinolone
15	Systemic Methylprednisolone in Chronic Rhinosinusitis	Completed	NCT01205984	Phase 4	methylprednisolone
16	Sinuclean's Treatment Of Sinusitis' Symptoms	Completed	NCT00747747	Phase 4
17	Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox	Completed	NCT00668304	Phase 4	Avelox (Moxifloxacin, BAY12-8039)
18	Study of the Safety and Efficacy of Cefdinir and Levofloxacin for the Treatment of Subjects With Acute Bacterial Sinusitis	Completed	NCT00645073	Phase 4	cefdinir (Omnicef);levofloxacin
19	Study to Evaluate Safety and Effectiveness of AdvaCoat Sinus Gel	Completed	NCT00554190	Phase 4
20	Treatment of Acute Sinusitis	Completed	NCT00377403	Phase 4	Acetaminophen;Amoxicillin;Dextromethorphan hydrobromide with guaifenesin;Guaifenesin;Pseudoephedrine Sustained Action;Saline spray (0.65%)
21	Zmax Compared to Augmentin in Sinusitis	Completed	NCT00367120	Phase 4	Azithromycin Extended Release;Amoxicillin/Clavulanate
22	Hemostatic Matrix in Endoscopic Sinus Surgery	Completed	NCT00242437	Phase 4
23	CHOOSE : Telithromycin, Acute Bacterial Sinusitis	Completed	NCT00174694	Phase 4	Telithromycin
24	Comparison Study Between Cefdinir & Amoxicilline/Clavulanate in Acute Sinusitis and Assessment of Quality of Life	Completed	NCT00147914	Phase 4	Cefdinir (drug);amoxicillin/clavulanate
25	The Impact Of The Addition Of Budesonide To Low-Pressure, High-Volume Saline Sinus Irrigation For Chronic Rhinosinusitis	Completed	NCT02696850	Phase 4	Budesonide;Saline alone
26	Xolair in Patients With Chronic Sinusitis	Completed	NCT00117611	Phase 4	Anti-IgE antibody omalizumab or placebo
27	Omeprazole 20 mg in Patients With Laryngopharyngeal reﬂux and Comorbid Chronic Rhinosinusitis	Completed	NCT03086070	Phase 4	Omeprazole 20mg;Placebo oral capsule
28	Study of Asthma and Nasal Steroids	Completed	NCT01118312	Phase 4	Mometasone Furoate monohydrate
29	Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers	Completed	NCT00208065	Phase 4	almotriptan or pseudoephedrine
30	Total Intravenous Anesthesia in Sinus Surgery	Recruiting	NCT02578862	Phase 4	Propofol;Sevoflurane
31	The Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis and Recurrent Sinusitis	Recruiting	NCT02582099	Phase 4	Gentamicin nasal irrigation;Normal saline nasal irrigation
32	Systemic Corticosteroids in the Perioperative Management of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)	Recruiting	NCT02119273	Phase 4	Prednisone;Placebo
33	Response of the Airway in Sinusitis and Asthma	Recruiting	NCT03011632	Phase 4	Mometasone Nasal;placebo mometasone
34	Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study	Active, not recruiting	NCT00841802	Phase 4	Prednisone
35	Prophylactic Antibiotics After Functional Endoscopic Sinus Surgery: a Randomized, Double-blind Placebo Controlled Trial	Active, not recruiting	NCT01919411	Phase 4	Amoxicillin-Potassium Clavulanate;Placebo
36	Treatment of Acute Sinusitis With High-Dose vs. Standard-Dose Amoxicillin/Clavulanate	Not yet recruiting	NCT03431337	Phase 4	Amoxicillin 875 mg
37	Use of Perioperative Antibiotics in Endoscopic Sinus Surgery	Not yet recruiting	NCT03369717	Phase 4	Amoxi Clavulanate
38	Canadian Health Economics, Outcome, and Effectiveness Comparison of Treatment in Patients With Chronic Rhinosinusitis	Terminated	NCT01455948	Phase 4
39	Corticosteroid Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)	Terminated	NCT01676415	Phase 4	Prednisone;Topical mometasone
40	Study of the Use of LUMA Lightwire	Terminated	NCT00705237	Phase 4
41	Study to Evaluate the Efficacy and Safety of Moxifloxacin Versus Amoxicillin/Clavulanate in the Treatment of Acute Bacterial Rhinosinusitis	Terminated	NCT00493038	Phase 4	Moxifloxacin (Avelox, BAY12-8039);Amoxicillin/Clavulanate
42	Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis	Terminated	NCT00245440	Phase 4	Azithromycin;Telithromycin
43	Sinusitis and Facial Pain Disorders Anti-Depression Trial	Terminated	NCT00754793	Phase 4	escitalopram;placebo
44	Nasospore Stent For Use in Enodscopic Sinus Surgery	Withdrawn	NCT00671541	Phase 4	Merogel Nasal Stent and Nasopore Stent;Nasopore Stent and either Gentamycin or Bacitracin
45	Effects of Anti-IgE Antibody Omalizumab on Patients With Chronic Sinusitis	Withdrawn	NCT00603785	Phase 4	Placebo;Xolair
46	Mitomicin C for Prevention Postoperative Endoscopic Sinus Surgery Synechia and QOL in Chronic Rhinosinusitis	Unknown status	NCT02106793	Phase 3	Mitomicin C;Identical placebo solution
47	The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery	Unknown status	NCT00852410	Phase 3	1% lidocaine with 1:100,000 adrenaline;1% lidocaine with 1:200,000 adrenaline
48	Prednisone in Chronic Rhinosinusitis Without Nasal Polyps	Unknown status	NCT02367118	Phase 3	Prednisone;Placebo
49	The Effect of RF Turbinoplasty in Polypoid Change of Middle Turbinates	Unknown status	NCT01906697	Phase 3
50	A Study of Luffa Operculate Nasal Solution 5mg/mL Compared With Saline (NaCl 09%) for the Relief of Nasal Obstruction	Unknown status	NCT01248325	Phase 3	Luffa Operculate Nasal Solution 5mg/mL;Saline Solution (NaCl 0,9%)

Search NIH Clinical Center for Paranasal Sinus Disease

Cochrane evidence based reviews: paranasal sinus diseases

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Genetic Tests for Paranasal Sinus Disease

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Anatomical Context for Paranasal Sinus Disease

MalaCards organs/tissues related to Paranasal Sinus Disease:

³⁸

Eye, Bone, Lung, Colon, Breast, Liver, Kidney

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Publications for Paranasal Sinus Disease

Articles related to Paranasal Sinus Disease:

(show all 49)

#	Title	Authors	Year
1	Paranasal Sinus Disease in Children With Headache. ( 28831857 )	Vieira Neto R.J....Montenegro M.A.	2017
2	Higher Body Mass Index and Increased Prevalence of Paranasal Sinus Disease. ( 26830349 )	Kabeya Y....Shimada A.	2016
3	Pretransplant paranasal sinus disease is associated with a high incidence of transplant-related mortality in hematopoietic stem cell transplantation for children and adolescents. ( 27748554 )	Kishimoto K....Kobayashi K.	2016
4	Association between diabetes and increased prevalence of paranasal sinus disease: a cross-sectional study in Japanese adults. ( 25728620 )	Kabeya Y....Shimada A.	2015
5	A stereological study on the correlation of inferior turbinate hypertrophy and paranasal sinus disease. ( 24389985 )	Ural A....Candan H.	2014
6	Headaches caused by nasal and paranasal sinus disease. ( 24703542 )	Marmura M.J....Silberstein S.D.	2014
7	The impact of a patient's age on the clinical presentation of inflammatory paranasal sinus disease. ( 23702318 )	BuSaba N.Y.	2013
8	Prognosis for sixth nerve palsy arising from paranasal sinus disease. ( 24119609 )	Miller C....Chiu A.G.	2013
9	Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): treatments and long-term results of treatments. ( 21812808 )	Dixon P.M....Barakzai S.Z.	2012
10	Ophthalmic manifestations of paranasal sinus disease: a clinical grading system. ( 22411699 )	Al Anazy F.H....Al Dousary S.H.	2012
11	Clinical consensus statement: appropriate use of computed tomography for paranasal sinus disease. ( 23054429 )	Setzen G....Patel M.M.	2012
12	Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): ancillary diagnostic findings and involvement of the various sinus compartments. ( 21812807 )	Dixon P.M....Barakzai S.Z.	2012
13	Complications of nose and paranasal sinus disease. ( 23272436 )	Sajid T....Khan J.	2011
14	The expression of fibrinolytic components in chronic paranasal sinus disease. ( 21711960 )	Sejima T....Bachert C.	2011
15	Paranasal sinus disease in horses. ( 21870345 )	Waguespack R.W....Taintor J.	2011
16	Paranasal sinus disease and sputum eosinophilia in prednisone-dependent asthma. ( 21144367 )	Lui B.T....Nair P.	2010
17	Thyroid Eye Disease and Paranasal Sinus Disease. ( 20924307 )	Wiwanitkit V.	2010
18	Significance of blood-tinged post-nasal drip in paranasal sinus disease. ( 17888198 )	Chao T.K....Huang W.H.	2008
19	T-cell regulation in chronic paranasal sinus disease. ( 18423831 )	Van Bruaene N....Gevaert P.	2008
20	The incidence of concha bullosa and its relationship to nasal septal deviation and paranasal sinus disease. ( 15502150 )	Stallman J.S....Som P.M.	2004
21	Headaches due to nasal and paranasal sinus disease. ( 15062525 )	Silberstein S.D.	2004
22	The role of leukotriene inhibitors in patients with paranasal sinus disease. ( 12923360 )	Parnes S.M.	2003
23	CT characterization of inflammatory paranasal sinus disease in cystic fibrosis. ( 11972457 )	EggesbA...Kolmannskog F.	2002
24	Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. ( 11195032 )	Bachmann G....Michel O.	2000
25	Use of standard radiography to diagnose paranasal sinus disease of asthmatic children in Taiwan: comparison with computed tomography. ( 10466541 )	Chen L.C....Lin S.J.	1999
26	Optic nerve blindness due to paranasal sinus disease. ( 10420111 )	Fujimoto N....Nagata H.	1999
27	[Cytokines and chemokines in paranasal sinus diseases]. ( 10535064 )	Rudack C....Bachert C.	1999
28	Relative value of MR imaging as compared with CT in the diagnosis of inflammatory paranasal sinus disease. ( 9885603 )	HAohnel S....Jansen O.	1999
29	Imaging of paranasal sinus disease. ( 9168874 )	Bangert B.A.	1997
30	Imaging in paranasal sinus disease. ( 9619203 )	Teh J....Smith A.	1997
31	Correlation of clinical examination with computer tomography in paranasal sinus disease. ( 9209590 )	Casiano R.R.	1997
32	Paranasal sinus disease in patients with cystic fibrosis. ( 8834282 )	Nishioka G.J....Cook P.R.	1996
33	Malignant plasmacytoma appearing as invasive paranasal sinus disease after cardiac transplantation. ( 8883660 )	Kramer G.S....Gatenby R.A.	1996
34	Efficacy of systemic corticosteroid treatment for anosmia with nasal and paranasal sinus disease. ( 8560170 )	Ikeda K....Takasaka T.	1995
35	Nasal and paranasal sinus disease in patients with congenital velopharyngeal insufficiency. ( 8049050 )	Ishikawa Y....Amitani R.	1994
36	Paranasal sinus disease in HIV antibody positive patients. ( 8335314 )	Grant A....Miller R.F.	1993
37	The prevalence of paranasal sinus disease in HIV infection and AIDS on cranial MR imaging. ( 8472478 )	Chong W.K....Harrison M.J.	1993
38	Inflammatory paranasal sinus disease in Bell's palsy demonstrated by magnetic resonance imaging. ( 8372929 )	Stenquist M....Jonsson L.	1993
39	Effect of a topical vasoconstrictor on computed tomography of paranasal sinus disease. ( 8421421 )	Stringer S.P....Avino A.J.	1993
40	Endoscopic examination and treatment of paranasal sinus disease in 16 horses. ( 8116208 )	Ruggles A.J....Freeman D.E.	1993
41	Limited-slice CT in the evaluation of paranasal sinus disease in children. ( 1898816 )	Gross G.W....Ehrlich S.M.	1991
42	Paranasal sinus disease with intracranial extension: aspergillosis versus malignancy. ( 3131605 )	Sarti E.J....Camins M.B.	1988
43	Computed tomography in nasal and paranasal sinus disease. ( 6482629 )	Unger J.M....Duncavage J.A.	1984
44	Comparison between transillumination and the roentgenogram in diagnosing paranasal sinus disease. ( 7451769 )	Spector S.L....Philpot I.	1981
45	Enzyme therapy in the triad of paranasal sinus disease, allergic asthmatic bronchitis, and bronchiectasis. ( 14446650 )	SILBERT N.E.	1959
46	The changing years: their impact upon the management of paranasal sinus disease. ( 13583895 )	HILL F.T.	1958
47	The changing years: their impact upon the management of paranasal sinus disease. ( 13647565 )	HILL F.T.	1958
48	Chronic paranasal sinus disease in adults; factors influencing treatment. ( 18124358 )	Gill J.P.	1949
49	Modern trends in diagnosis and treatment of paranasal sinus disease with particular reference to allergic manifestations. ( 20261616 )	GILL E.K.	1947

Sources

Genes for Paranasal Sinus Disease

Genes related to Paranasal Sinus Disease (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Implication
1	IL5	Interleukin 5	Protein Coding	23.54	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	IL4	Interleukin 4	Protein Coding	22.83	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	IL13	Interleukin 13	Protein Coding	22.71	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	IFNG	Interferon Gamma	Protein Coding	21.47	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	IL10	Interleukin 10	Protein Coding	20.95	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
6	ALOX5	Arachidonate 5-Lipoxygenase	Protein Coding	20.92	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
7	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	17.68	GeneCards inferred via : Publications (show sections)
8	GATA3	GATA Binding Protein 3	Protein Coding	17.68	GeneCards inferred via : Publications (show sections)
9	IL17A	Interleukin 17A	Protein Coding	17.68	GeneCards inferred via : Publications (show sections)
10	PLAU	Plasminogen Activator, Urokinase	Protein Coding	17.68	GeneCards inferred via : Publications (show sections)
11	SERPINE1	Serpin Family E Member 1	Protein Coding	17.68	GeneCards inferred via : Publications (show sections)
12	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	17.68	GeneCards inferred via : Publications (show sections)
13	MUC5B	Mucin 5B, Oligomeric Mucus/Gel-Forming	Protein Coding	17.67	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
14	RHNO1	RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1	Protein Coding	17.37	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
15	FLNC	Filamin C	Protein Coding	16.65	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
16	CD79A	CD79a Molecule	Protein Coding	16.28	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)

Sources

Variations for Paranasal Sinus Disease

Sources

Expression for Paranasal Sinus Disease

Search GEO for disease gene expression data for Paranasal Sinus Disease.

Sources

Pathways for Paranasal Sinus Disease

Pathways related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

(show all 49)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶² Show member pathways Immune System ⁶² Neutrophil degranulation ⁶²	13.98	ALOX5 CD79A GATA3 IFNG IL10 IL13
2	PEDF Induced Signaling ⁶⁰ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁰ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶⁰ Glucocorticoid Receptor Signaling ⁶⁰ IL-6 Pathway ⁶⁰ MIF Mediated Glucocorticoid Regulation ⁶⁰ MIF Regulation of Innate Immune Cells ⁶⁰ NFAT Signaling and Lymphocyte Interactions ⁶⁰ PGC1Alpha Pathway ⁶⁰ RAR-Gamma-RXR-Alpha Degradation ⁶⁰ STAT3 Pathway ⁶⁰	13.63	ALOX5 IFNG IL10 IL13 IL17A IL4
3	Cytokine Signaling in Immune system ⁶² Show member pathways Signaling by Interleukins ⁶²	13.35	ALOX5 GATA3 IFNG IL10 IL13 IL17A
4	PAK Pathway ⁶⁰ Show member pathways Antioxidant Action of Vitamin-C ⁶⁰ Epithelial Adherens Junctions ⁶⁰	13.28	FLNC IL10 IL13 IL17A IL4 IL5
5	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶⁰ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶⁰ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.85	IFNG IL10 IL13 IL17A IL4 IL5
6	Pathways in cancer ³⁶	12.82	IFNG IL13 IL4 IL5 TGFB1
7	Immune response Fc epsilon RI pathway ²¹ Show member pathways Fc epsilon RI signaling pathway ³⁶ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²¹ VEGF signaling pathway ³⁶	12.59	ALOX5 CD79A IL13 IL4 IL5
8	NF-kappaB Signaling ⁴	12.57	ALOX5 CD79A GATA3 IFNG IL10 IL17A
9	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶⁰ Immune response IL-22 signaling pathway ²¹ Inflammatory bowel disease (IBD) ³⁶ Th1 and Th2 cell differentiation ³⁶	12.57	GATA3 IFNG IL10 IL13 IL17A IL4
10	Toll-like receptor signaling pathway ¹ ³⁶ Show member pathways Chagas disease (American trypanosomiasis) ³⁶	12.49	IFNG IL10 SERPINE1 TGFB1
11	T cell receptor signaling pathway ³⁶ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.43	GATA3 IFNG IL10 IL17A IL4 IL5
12	Jak-STAT signaling pathway (KEGG) ³⁶ Show member pathways B-Cell Development ⁶⁰ IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶¹ Interleukin-19, 20, 22, 24 ⁶² Jak/STAT Signaling Pathway ⁶¹	12.38	IFNG IL10 IL13 IL4 IL5
13	IL-17 Family Signaling Pathways ⁶¹ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶² Mucin expression in CF via IL-6, IL-17 signaling pathways ²¹	12.35	IFNG IL13 IL17A IL4 IL5 MUC5B
14	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶² thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.32	ALOX5 IFNG IL4 SERPINE1
15	Proteoglycans in cancer ³⁶	12.29	FLNC PLAU PLAUR TGFB1
16	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.29	ALOX5 IFNG IL10 IL4 TGFB1
17	Immune response IFN alpha/beta signaling pathway ²¹ Show member pathways Cytokine Network ⁶⁰ Interferon alpha/beta signaling ⁶² Regulation of IFNA signaling ⁶²	12.18	IFNG IL10 IL13 IL17A IL4 IL5
18	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶¹	12.02	CD79A IFNG IL10 IL4 IL5
19	Senescence and Autophagy in Cancer ¹	11.97	IFNG PLAU SERPINE1 TGFB1
20	Spinal Cord Injury ¹	11.96	IFNG IL4 TGFB1
21	IL27-mediated signaling events ¹ Show member pathways IL-12 Family Signaling Pathways ⁶¹ Interleukin-12 signaling ⁶² Th1 Differentiation Pathway ⁶¹	11.96	GATA3 IFNG IL10 IL17A TGFB1
22	Interleukin-4 and 13 signaling ⁶²	11.92	ALOX5 GATA3 IL10 IL13 IL17A IL4
23	Th17 Differentiation Pathway ⁶¹ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶¹	11.9	IFNG IL17A IL4 TGFB1
24	Amoebiasis ³⁶	11.86	IFNG IL10 TGFB1
25	Glucocorticoid receptor regulatory network ¹	11.84	GATA3 IFNG IL13 IL4 IL5
26	Rheumatoid arthritis ³⁶	11.83	IFNG IL17A TGFB1
27	Regulation of nuclear SMAD2/3 signaling ¹	11.82	GATA3 IL10 IL5 SERPINE1
28	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.8	GATA3 IFNG IL4 IL5
29	Dendritic Cells Developmental Lineage Pathway ⁶¹	11.74	IFNG IL10 TGFB1
30	IgA-Producing B Cells in the Intestine ⁶¹	11.73	IL10 IL4 IL5 TGFB1
31	IL4-mediated signaling events ¹	11.66	IL10 IL4 IL5
32	Cell adhesion_ECM remodeling ²¹	11.64	PLAU PLAUR SERPINE1
33	Lung fibrosis ¹	11.64	IL13 IL4 IL5 MUC5B PLAU TGFB1
34	TGF-beta Receptor Signaling (WikiPathways) ¹	11.62	IFNG SERPINE1 TGFB1
35	Innate Lymphoid Cell Differentiation Pathways ⁶¹	11.6	GATA3 IFNG IL10 IL13 IL17A IL4
36	Interleukin-10 signaling ⁶²	11.54	IL10 IL13 IL4
37	Malaria ³⁶	11.53	IFNG IL10 TGFB1
38	Th2 Differentiation Pathway ⁶¹	11.4	GATA3 IFNG IL10 IL13 IL4 IL5
39	IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶¹ Show member pathways IL-2 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶¹	11.39	IFNG IL10 TGFB1
40	Inflammatory Response Pathway ¹	11.35	IFNG IL4 IL5
41	IL12 signaling mediated by STAT4 ¹	11.27	IFNG IL13 TGFB1
42	G-protein signaling_RhoB regulation pathway ²¹	11.24	IL10 IL13 IL17A IL4 IL5
43	OX40 Pathway ⁶⁰	11.22	IFNG IL10 IL13 IL4 IL5
44	IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶¹	11.04	GATA3 IL4 TGFB1
45	G-protein signaling_Rap2B regulation pathway ²¹	11.03	IL10 IL13 IL17A IL4 IL5 TGFB1
46	Development and heterogeneity of the ILC family ¹	10.94	GATA3 IFNG IL13 IL17A IL4 IL5
47	Dissolution of Fibrin Clot ⁶²	10.88	PLAU PLAUR SERPINE1
48	IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶¹	10.84	IL13 IL4 IL5 TGFB1
49	Cytokines and Inflammatory Response ¹	10.58	IFNG IL10 IL13 IL4 IL5 TGFB1

Sources

GO Terms for Paranasal Sinus Disease

Cellular components related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.73	ALOX5 IFNG IL10 IL13 IL17A IL4
2	extracellular space	GO:0005615	9.36	ALOX5 IFNG IL10 IL13 IL17A IL4

Biological processes related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

(show all 23)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	9.96	GATA3 IL10 IL4 IL5 TGFB1
2	immune response	GO:0006955	9.8	IFNG IL10 IL13 IL17A IL4 IL5
3	movement of cell or subcellular component	GO:0006928	9.71	IFNG IL13 PLAUR
4	B cell differentiation	GO:0030183	9.69	CD79A IL10 IL4
5	inflammatory response	GO:0006954	9.63	ALOX5 IL10 IL13 IL17A IL5 TGFB1
6	positive regulation of T cell differentiation	GO:0045582	9.61	GATA3 IL4
7	myeloid dendritic cell differentiation	GO:0043011	9.61	IL4 TGFB1
8	positive regulation of macrophage activation	GO:0043032	9.6	IL10 IL13
9	positive regulation of transcription regulatory region DNA binding	GO:2000679	9.59	GATA3 TGFB1
10	cell activation	GO:0001775	9.58	GATA3 TGFB1
11	regulation of regulatory T cell differentiation	GO:0045589	9.58	IFNG TGFB1
12	positive regulation of B cell proliferation	GO:0030890	9.58	IL13 IL4 IL5
13	negative regulation of interleukin-17 production	GO:0032700	9.55	IFNG TGFB1
14	positive regulation of interleukin-13 production	GO:0032736	9.52	GATA3 IL4
15	positive regulation of MHC class II biosynthetic process	GO:0045348	9.49	IL10 IL4
16	type 2 immune response	GO:0042092	9.48	IL10 IL4
17	positive regulation of interleukin-23 production	GO:0032747	9.46	IFNG IL17A
18	regulation of isotype switching	GO:0045191	9.43	IL10 IL4
19	fibrinolysis	GO:0042730	9.43	PLAU PLAUR SERPINE1
20	negative regulation of complement-dependent cytotoxicity	GO:1903660	9.37	IL13 IL4
21	negative regulation of endothelial cell apoptotic process	GO:2000352	9.35	GATA3 IL10 IL13 IL4 SERPINE1
22	regulation of receptor activity	GO:0010469	9.28	IFNG IL10 IL13 IL17A IL4 IL5
23	positive regulation of transcription by RNA polymerase II	GO:0045944	10.04	GATA3 IL10 IL17A IL4 SERPINE1 TGFB1

Molecular functions related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.86	ALOX5 CD79A FLNC GATA3 IFNG IL10
2	growth factor activity	GO:0008083	9.46	IL10 IL4 IL5 TGFB1
3	cytokine activity	GO:0005125	9.17	IFNG IL10 IL13 IL17A IL4 IL5

Sources

Sources for Paranasal Sinus Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ ExPASy

¹⁷ FDA Approved Drugs

¹⁸ FMA

¹⁹ GeneAnalytics

²⁰ GeneCards

²¹ GeneGo (Thomson Reuters)

²² GeneHancer via GeneCards

²³ GeneReviews

²⁴ Genetics Home Reference

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HGMD

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ MalaCards

³⁹ MedGen

⁴⁰ MedlinePlus

⁴¹ MeSH

⁴² MESH via Orphanet

⁴³ MGI

⁴⁴ NCBI Bookshelf

⁴⁵ NCI

⁴⁶ NCIt

⁴⁷ NDF-RT

⁴⁸ NIH Clinical Center

⁴⁹ NIH Rare Diseases

⁵⁰ NINDS

⁵¹ Novoseek

⁵² Novus Biologicals

⁵³ OMIM

⁵⁴ OMIM via Orphanet

⁵⁵ Orphanet

⁵⁶ PathCards

⁵⁷ PharmGKB

⁵⁸ PubMed

⁵⁹ PubMed Health

⁶⁰ QIAGEN

⁶¹ R&D Systems

⁶² Reactome

⁶³ Sino Biological

⁶⁴ SNOMED-CT

⁶⁵ SNOMED-CT via HPO

⁶⁶ SNOMED-CT via Orphanet

⁶⁷ TGDB

⁶⁸ Tocris

⁶⁹ UMLS

⁷⁰ UMLS via Orphanet

⁷¹ UniProtKB/Swiss-Prot

⁷² Wikipedia