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MCID: PRN021
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Paranasal Sinus Disease malady
7 genes, 121 related diseases, clinical trials.

Summaries for Paranasal Sinus Disease

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64Wikipedia, 33MalaCards
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Wikipedia:64 Paranasal sinuses are a group of four paired air-filled spaces that surround the nasal cavity (maxillary... more...

MalaCards: Paranasal Sinus Disease, also known as paranasal sinus disorder, is related to asthma and cystic fibrosis. An important gene associated with Paranasal Sinus Disease is IL17A (interleukin 17A), and among its related pathways are Senescence and Autophagy and PEDF Induced Signaling. The compounds pge2 and nickel have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and tumorigenesis.

Aliases & Classifications for Paranasal Sinus Disease

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Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

paranasal sinus disease 8
paranasal sinus disorder 8
paranasal sinus diseases 61
disorder of nasal sinus 8


External Ids:

Disease Ontology8 DOID:1352
NCIt40 C26843
SNOMED-CT57 7393007
MeSH35 D010254

Related Diseases for Paranasal Sinus Disease

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17GeneCards, 18GeneDecks
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Diseases related to Paranasal Sinus Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1asthma30.5IFNG, IL5, IL17A, PLAUR, ALOX5
2cystic fibrosis30.4IL17A
3aspergillosis30.2IFNG
4bronchitis30.2ALOX5, IL17A
5allergic asthma30.2IFNG, IL5, IL17A, ALOX5
6bell's palsy10.2
7bronchiectasis10.2
8headache10.2
9blindness10.2
10gingivitis10.0IL17A
11infertility10.0IL17A
12gastritis10.0IL17A
13nephrotic syndrome10.0IL17A
14encephalitis10.0IL17A
15cervical cancer10.0IL17A
16cholera10.0IL17A
17rhinitis10.0IL5
18bladder carcinoma10.0PLAUR
19esophagitis10.0IL5
20polymyositis10.0IL17A
21hypersensitivity reaction type ii disease10.0IL17A
22diphtheria10.0PLAUR
23churg-strauss syndrome10.0IL5
24dermatomyositis10.0IL17A
25bronchiolitis10.0IL5
26eosinophilic fasciitis10.0IL5
27pleurisy10.0ALOX5
28peritonitis10.0ALOX5
29glomerulonephritis10.0ALOX5
30mycosis fungoides10.0IL5
31eosinophilia-myalgia syndrome10.0IL5
32vascular disease10.0PLAU
33lung cancer10.0PLAU
34thrombocytopenia10.0ALOX5
35strongyloidiasis10.0IL5
36myocardial infarction10.0SERPINE1
37pulmonary eosinophilia10.0IL5
38aids dementia complex10.0PLAUR
39omenn syndrome10.0IL5
40meningioma10.0ALOX5
41polycystic ovary syndrome10.0SERPINE1
42acute myocardial infarction10.0SERPINE1
43eosinophilic esophagitis10.0IL5
44arteriosclerosis10.0SERPINE1
45onchocerciasis10.0IL5
46nephritis10.0IL17A
47hypertension10.0SERPINE1
48insulin resistance10.0SERPINE1
49primary hyperoxaluria10.0SERPINE1
50benign meningioma10.0PLAU

Graphical network of the top 20 diseases related to Paranasal Sinus Disease:



Diseases related to paranasal sinus disease

Clinical Features for Paranasal Sinus Disease

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Drugs & Therapeutics for Paranasal Sinus Disease

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Paranasal Sinus Disease

Drug clinical trials:

Search ClinicalTrials for Paranasal Sinus Disease

Search NIH Clinical Center for Paranasal Sinus Disease

Search CenterWatch for Paranasal Sinus Disease

Genetic Tests for Paranasal Sinus Disease

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Anatomical Context for Paranasal Sinus Disease

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Animal Models for Paranasal Sinus Disease or affiliated genes

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Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Paranasal Sinus Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
respiratory system phenotype
MP:00053889.7PLAUR, PLAU
2
tumorigenesis
MP:00020069.2IL5, IFNG
3
digestive/alimentary phenotype
MP:00053818.3PLAU, IL17A, IL5, IFNG
4
homeostasis/metabolism phenotype
MP:00053768.2ALOX5, SERPINE1, IL5, IFNG
5
renal/urinary system phenotype
MP:00053677.9IFNG, IL17A, PLAUR, SERPINE1
6
liver/biliary system phenotype
MP:00053707.7IFNG, IL5, PLAU, PLAUR, SERPINE1
7
cardiovascular system phenotype
MP:00053857.5IFNG, PLAU, PLAUR, SERPINE1, ALOX5
8
hematopoietic system phenotype
MP:00053976.9ALOX5, IFNG, IL5, IL17A, PLAU, PLAUR
9
immune system phenotype
MP:00053876.9IFNG, IL5, IL17A, PLAU, PLAUR, SERPINE1

Publications for Paranasal Sinus Disease

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Sources:
51PubMed
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Articles related to Paranasal Sinus Disease:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
The impact of a patient's age on the clinical presentation of inflammatory paranasal sinus disease. (23702318)
2013
2
Immunoglobulin G4-related sclerosing disease of the paranasal sinus. (23047661)
2013
3
Prognosis for sixth nerve palsy arising from paranasal sinus disease. (24119609)
2013
4
Ophthalmic manifestations of paranasal sinus disease: a clinical grading system. (22411699)
2012
5
Clinical consensus statement: appropriate use of computed tomography for paranasal sinus disease. (23054429)
2012
6
Immunoglobulin G4-related sclerosing disease mimicking invasive tumor in the nasal cavity and paranasal sinuses. (21546462)
2012
7
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): ancillary diagnostic findings and involvement of the various sinus compartments. (21812807)
2012
8
Intercurrent infectious diseases in post-stem cell transplant patients: paranasal sinusitis. (22337395)
2012
9
Rosai-Dorfman disease of the paranasal sinuses and orbit. (21727770)
2011
10
Ophthalmic complications following treatment of paranasal sinus rhabdomyosarcoma in comparison to orbital disease. (21242849)
2011
11
Paranasal sinus disease in horses. (21870345)
2011
12
Complications of nose and paranasal sinus disease. (23272436)
2011
13
The expression of fibrinolytic components in chronic paranasal sinus disease. (21711960)
2011
14
Thyroid Eye Disease and Paranasal Sinus Disease. (20924307)
2010
15
Paranasal sinus disease and sputum eosinophilia in prednisone-dependent asthma. (21144367)
2010
16
T-cell regulation in chronic paranasal sinus disease. (18423831)
2008
17
Total IgE levels and peripheral eosinophilia: correlation with mucosal disease based on computed tomographic imaging of the paranasal sinus. (17638784)
2007
18
Nasal and paranasal sinus manifestation of Rosai-Dorfman disease. (16218519)
2005
19
A rare case of Rosai-Dorfman disease of the paranasal sinuses. (23120220)
2005
20
Rosai-Dorfman disease involving the cranial base, paranasal sinuses and spinal cord. (16033137)
2005
21
Extranodal Rosai-Dorfman disease of bone, subcutaneous tissue and paranasal sinus mucosa with a review of its pathogenesis. (16096753)
2005
22
The incidence of concha bullosa and its relationship to nasal septal deviation and paranasal sinus disease. (15502150)
2004
23
Headaches due to nasal and paranasal sinus disease. (15062525)
2004
24
The role of leukotriene inhibitors in patients with paranasal sinus disease. (12923360)
2003
25
CT characterization of inflammatory paranasal sinus disease in cystic fibrosis. (11972457)
2002
26
Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. (11195032)
2000
27
Use of standard radiography to diagnose paranasal sinus disease of asthmatic children in Taiwan: comparison with computed tomography. (10466541)
1999
28
Optic nerve blindness due to paranasal sinus disease. (10420111)
1999
29
Cytokines and chemokines in paranasal sinus diseases]. (10535064)
1999
30
Relative value of MR imaging as compared with CT in the diagnosis of inflammatory paranasal sinus disease. (9885603)
1999
31
Imaging in paranasal sinus disease. (9619203)
1997
32
Correlation of clinical examination with computer tomography in paranasal sinus disease. (9209590)
1997
33
Malignant plasmacytoma appearing as invasive paranasal sinus disease after cardiac transplantation. (8883660)
1996
34
Paranasal sinus disease in patients with cystic fibrosis. (8834282)
1996
35
Efficacy of systemic corticosteroid treatment for anosmia with nasal and paranasal sinus disease. (8560170)
1995
36
Nasal and paranasal sinus disease in patients with congenital velopharyngeal insufficiency. (8049050)
1994
37
Effect of a topical vasoconstrictor on computed tomography of paranasal sinus disease. (8421421)
1993
38
Endoscopic examination and treatment of paranasal sinus disease in 16 horses. (8116208)
1993
39
Inflammatory paranasal sinus disease in Bell's palsy demonstrated by magnetic resonance imaging. (8372929)
1993
40
Paranasal sinus disease in HIV antibody positive patients. (8335314)
1993
41
Limited-slice CT in the evaluation of paranasal sinus disease in children. (1898816)
1991
42
Paranasal sinus disease with intracranial extension: aspergillosis versus malignancy. (3131605)
1988
43
Computed tomography in nasal and paranasal sinus disease. (6482629)
1984
44
Comparison between transillumination and the roentgenogram in diagnosing paranasal sinus disease. (7451769)
1981
45
Myospherulosis of the paranasal sinuses, nose and middle ear. A possible iatrogenic disease. (836618)
1977
46
Enzyme therapy in the triad of paranasal sinus disease, allergic asthmatic bronchitis, and bronchiectasis. (14446650)
1959
47
The changing years: their impact upon the management of paranasal sinus disease. (13647565)
1958
48
The changing years: their impact upon the management of paranasal sinus disease. (13583895)
1958
49
Chronic paranasal sinus disease in adults; factors influencing treatment. (18124358)
1949
50
Modern trends in diagnosis and treatment of paranasal sinus disease with particular reference to allergic manifestations. (20261616)
1947

Genetic Variations for Paranasal Sinus Disease

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Expression for genes affiliated with Paranasal Sinus Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paranasal Sinus Disease

Search GEO for disease gene expression data for Paranasal Sinus Disease.

Pathways for genes affiliated with Paranasal Sinus Disease

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Sources:
38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 54Reactome, 53R&D Systems, 12EMD Millipore
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Pathways related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Senescence and Autophagy38
9.9SERPINE1
2
PEDF Induced Signaling52
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9.6IL5, IL17A
3
Validated transcriptional targets of AP1 family members Fra1 and Fra238
9.5PLAUR, PLAU
4
FGF signaling pathway38
9.5PLAUR, PLAU
5
amb2 Integrin signaling38
9.5PLAUR, PLAU
6
Formation of Fibrin Clot (Clotting Cascade)54
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9.3PLAU, SERPINE1
7
IL27-mediated signaling events38
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9.3IL17A, IFNG
8
Cytokine Network52
9.2IFNG, IL5
9
Calcium signaling in the CD4+ TCR pathway38
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9.2IFNG, IL5
10
Inflammatory Response Pathway38
9.2IL5, IFNG
11
OX40 Pathway52
9.2IL5, IFNG
12
ATF-2 transcription factor network38
9.1PLAU, IFNG
13
Platelet activation, signaling and aggregation54
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8.9PLAU, PLAUR, SERPINE1
14
Complement and coagulation cascades30
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8.9SERPINE1, PLAUR, PLAU
15
Dissolution of Fibrin Clot54
8.9SERPINE1, PLAUR, PLAU
16
Cell adhesion ECM remodeling
Hide members
8.9SERPINE1, PLAUR, PLAU
17
Translation Insulin regulation of translation
Hide members
8.9SERPINE1, PLAUR, PLAU
18
B cell receptor signaling pathway30
Hide members
8.8IL17A, IL5, IFNG
19
Selenium Pathway38
8.5IFNG, SERPINE1, ALOX5
20
Leishmaniasis30
Hide members
8.3IFNG, IL5, IL17A, ALOX5

Compounds for genes affiliated with Paranasal Sinus Disease

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Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 2BitterDB, 50PharmGKB
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Compounds related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1pge24510.4PLAU
2nickel45 2411.4IL5
3heparin45 29 11 2413.4ALOX5
4butyrate4510.4IL5
5rolipram45 60 2912.3ALOX5
6hydrocortisone45 2 60 1113.0PLAU
7endotoxin459.8PLAUR, SERPINE1
8Reteplase119.7PLAUR, SERPINE1
9Anistreplase119.7SERPINE1, PLAUR
10Alteplase119.7SERPINE1, PLAUR
11notoginsenoside r1459.7SERPINE1, PLAU
12nickel subsulfide459.6PLAU, SERPINE1
13dexamethasone45 50 29 1112.5ALOX5, IL5, PLAUR
145-oxoete459.5IL5, PLAUR, ALOX5
15aa861459.5IL5, ALOX5
16n-formylmethionyl-leucylphenylalanine459.4PLAUR, ALOX5, IL5
17eaca459.4PLAU, SERPINE1, PLAUR
18p-amino benzamidine459.4PLAU, PLAUR, SERPINE1
19Urokinase119.3PLAU, PLAUR, SERPINE1
20tranexamic acid45 1110.3PLAU, SERPINE1, PLAUR
21epsilon aminocaproic acid459.3PLAUR, PLAU, SERPINE1
22thapsigargin45 6010.3SERPINE1, PLAU, PLAUR
23diisopropylfluorophosphate459.3SERPINE1, PLAU, PLAUR
24cerivastatin45 50 29 1112.3PLAUR, SERPINE1, PLAU
25hirudin459.3PLAUR, PLAU, SERPINE1
26saporin459.2PLAU, PLAUR
27kininogen459.2SERPINE1, PLAU, PLAUR
28glucosamine45 11 2411.1IFNG, IL5, PLAUR
29creatinine459.1PLAUR, PLAU, IL17A
30curcumin459.0PLAUR, PLAU, IL17A, ALOX5
31aprotinin45 1110.0SERPINE1, PLAU, PLAUR
32sp 60012545 6010.0PLAU, SERPINE1, IL17A
33dmso459.0PLAUR, ALOX5, PLAU, IL5
34vitamin d458.8PLAUR, SERPINE1, IL5, ALOX5
35aspirin45 50 29 2411.8PLAUR, ALOX5, SERPINE1, PLAU
36pd 98,059458.8SERPINE1, PLAUR, PLAU, IL17A
37ly294002458.7SERPINE1, IL17A, PLAU, IL5
3815-deoxy-delta-12,14-prostaglandin j2458.7PLAU, IFNG, SERPINE1
39calcitriol45 60 11 2411.6ALOX5, PLAU, PLAUR, IFNG
40histamine45 29 2410.4IFNG, ALOX5, IL5, PLAU
41thymidine45 249.3PLAUR, PLAU, IL17A, IFNG, IL5
42herbimycin a45 609.2ALOX5, IFNG, IL5, PLAU, PLAUR
43actinomycin d458.1PLAUR, IL17A, IFNG, PLAU, SERPINE1
44tacrolimus45 50 1110.1IFNG, IL17A, SERPINE1, IL5, ALOX5
45arginine458.1IFNG, IL5, PLAU, PLAUR, ALOX5
46indomethacin45 60 29 1110.8IL5, IL17A, PLAU, PLAUR, IFNG, ALOX5
47retinoic acid45 248.8PLAUR, IFNG, IL5, PLAU, SERPINE1
48genistein45 29 60 2 11 2412.6IFNG, IL5, PLAU, PLAUR, SERPINE1, ALOX5
49sb 20358045 608.2ALOX5, PLAUR, PLAU, IL17A, IL5, IFNG
50vegf457.2PLAU, SERPINE1, ALOX5, PLAUR, IFNG, IL5

GO Terms for genes affiliated with Paranasal Sinus Disease

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Sources:
16Gene Ontology
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Cellular components related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.6IL5, PLAU, PLAUR, SERPINE1, IFNG
2extracellular spaceGO:0056157.4SERPINE1, PLAU, IL17A, IL5, IFNG

Biological processes related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoclast differentiationGO:0456729.3IL17A, IFNG
2positive regulation of interleukin-23 productionGO:0327479.2IL17A, IFNG
3regulation of receptor activityGO:0104699.0SERPINE1, PLAU
4fibrinolysisGO:0427308.9SERPINE1, PLAUR, PLAU

Molecular functions related to Paranasal Sinus Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.8IL17A, IL5, IFNG

Products for genes affiliated with Paranasal Sinus Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Paranasal Sinus Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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