MCID: PRN021
MIFTS: 51

Paranasal Sinus Disease

Categories: Respiratory diseases

Aliases & Classifications for Paranasal Sinus Disease

MalaCards integrated aliases for Paranasal Sinus Disease:

Name: Paranasal Sinus Disease 12 14
Paranasal Sinus Diseases 41 69
Disorder of Nasal Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1352
MeSH 41 D010254
NCIt 46 C26843
SNOMED-CT 64 195823002 7393007
UMLS 69 C0030469

Summaries for Paranasal Sinus Disease

MalaCards based summary : Paranasal Sinus Disease, also known as paranasal sinus diseases, is related to aging and aspergillosis. An important gene associated with Paranasal Sinus Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Amoxicillin and Cefditoren have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and lung, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 72 Paranasal sinuses are a group of four paired air-filled spaces that surround the nasal cavity. The... more...

Related Diseases for Paranasal Sinus Disease

Diseases related to Paranasal Sinus Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 aging 29.6 IL10 SERPINE1 TGFB1
2 aspergillosis 29.5 CD79A IFNG IL10 IL4 IL5
3 asthma 28.2 ALOX5 CD79A GATA3 IFNG IL10 IL13
4 cytokine deficiency 10.6 IL13 IL5
5 mycoplasmal pneumonia 10.6 IFNG IL4
6 eosinophilic fasciitis 10.6 IFNG IL5
7 tropical endomyocardial fibrosis 10.5 IL10 IL4
8 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL13 IL5
9 ascaridiasis 10.5 IL10 IL13
10 respiratory syncytial virus infectious disease 10.5 IL13 IL5
11 tungiasis 10.5 IL10 IL4
12 b-cell growth factor 10.5 IFNG IL4
13 endomyocardial fibrosis 10.5 IL10 IL4
14 african tick-bite fever 10.5 IFNG IL13
15 cough variant asthma 10.5 IL4 IL5
16 paragonimiasis 10.5 IL13 IL5
17 inflammatory bowel disease 4 10.5 IL13 IL4 IL5
18 latex allergy 10.5 IL13 IL4 IL5
19 atopic keratoconjunctivitis 10.5 IFNG IL4 IL5
20 intestinal schistosomiasis 10.5 IL13 IL4 IL5
21 chronic conjunctivitis 10.5 IL13 IL4 IL5
22 eosinophilic gastritis 10.5 IL13 IL4 IL5
23 chronic tic disorder 10.5 IL13 IL4 IL5
24 vernal keratoconjunctivitis 10.5 IL13 IL4 IL5
25 penicillin allergy 10.4 IFNG IL13 IL4
26 folliculitis 10.4 IFNG IL4 IL5
27 toxic oil syndrome 10.4 IFNG IL4 IL5
28 hyperlucent lung 10.4 IFNG IL10 IL4
29 pulmonary eosinophilia 10.4 IL13 IL4 IL5
30 necatoriasis 10.4 IL10 IL5
31 onchocerciasis 10.4 IL13 IL4 IL5
32 beta-lactam allergy 10.4 IL10 IL13 IL4
33 baylisascariasis 10.4 IFNG IL10 IL4
34 neurosyphilis 10.4 IL10 IL17A
35 leukocyte disease 10.4 IL13 IL4 IL5
36 multicentric castleman disease 10.4 IFNG IL10 IL5
37 buruli ulcer 10.4 IFNG IL10 IL4
38 perforated corneal ulcer 10.4 PLAU PLAUR
39 poliomyelitis 10.4 IFNG IL10 IL4
40 eales disease 10.4 IFNG IL10 IL4
41 peanut allergy 10.4 IFNG IL10 IL13
42 trichosporonosis 10.4 IFNG IL17A
43 sezary's disease 10.4 IFNG IL4 IL5
44 acute graft versus host disease 10.4 IFNG IL10 IL4
45 juvenile myasthenia gravis 10.4 IL10 TGFB1
46 brucellosis 10.4 IFNG IL10 IL4
47 filariasis 10.4 IFNG IL10 IL5
48 retinitis pigmentosa 22 10.4 IL10 IL4
49 immune suppression 10.4 IFNG IL10
50 toxic shock syndrome 10.3 IFNG IL10 IL4

Graphical network of the top 20 diseases related to Paranasal Sinus Disease:



Diseases related to Paranasal Sinus Disease

Symptoms & Phenotypes for Paranasal Sinus Disease

MGI Mouse Phenotypes related to Paranasal Sinus Disease:

43 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 TGFB1 GATA3 ALOX5 CD79A IFNG FLNC
2 hematopoietic system MP:0005397 10.37 TGFB1 ALOX5 CD79A IFNG GATA3 IL10
3 growth/size/body region MP:0005378 10.35 TGFB1 GATA3 IFNG FLNC IL13 IL10
4 immune system MP:0005387 10.34 TGFB1 GATA3 ALOX5 CD79A IFNG IL10
5 cellular MP:0005384 10.32 TGFB1 GATA3 ALOX5 CD79A IFNG IL4
6 cardiovascular system MP:0005385 10.24 SERPINE1 TGFB1 IFNG GATA3 ALOX5 FLNC
7 digestive/alimentary MP:0005381 10.21 TGFB1 GATA3 IFNG IL13 IL10 IL17A
8 mortality/aging MP:0010768 10.17 SERPINE1 TGFB1 IFNG GATA3 FLNC IL13
9 endocrine/exocrine gland MP:0005379 10.15 TGFB1 IFNG GATA3 IL13 IL17A IL10
10 integument MP:0010771 10.13 TGFB1 GATA3 IFNG FLNC IL4 IL13
11 craniofacial MP:0005382 10.11 TGFB1 IFNG GATA3 IL4 IL17A IL10
12 liver/biliary system MP:0005370 10.11 TGFB1 CD79A IFNG IL10 IL4 PLAU
13 muscle MP:0005369 10.01 TGFB1 GATA3 FLNC IFNG IL13 IL10
14 neoplasm MP:0002006 9.91 TGFB1 CD79A IFNG IL10 SERPINE1 PLAU
15 no phenotypic analysis MP:0003012 9.87 IFNG GATA3 CD79A IL13 IL17A IL10
16 renal/urinary system MP:0005367 9.86 TGFB1 GATA3 CD79A IFNG IL4 IL17A
17 reproductive system MP:0005389 9.76 TGFB1 IFNG GATA3 IL13 IL10 IL4
18 respiratory system MP:0005388 9.73 TGFB1 IFNG FLNC IL10 IL17A IL4
19 skeleton MP:0005390 9.28 TGFB1 GATA3 ALOX5 IFNG IL4 IL13

Drugs & Therapeutics for Paranasal Sinus Disease

Drugs for Paranasal Sinus Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 322)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
2
Cefditoren Approved, Investigational Phase 4 104145-95-1, 117467-28-4 9870843 9571074
3
Montelukast Approved Phase 4 158966-92-8 5281040
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 1 53-03-2 5865
5
Epinephrine Approved, Vet_approved Phase 4,Phase 3 51-43-4 5816
6 Racepinephrine Approved Phase 4,Phase 3 329-65-7
7
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 53477736 447043 55185
8
Budesonide Approved Phase 4,Phase 2,Phase 3,Phase 1 51333-22-3 5281004 63006
9
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
10
Cocaine Approved, Illicit Phase 4 50-36-2 446220 5760
11
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
12
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
13
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
14
Remifentanil Approved Phase 4 132875-61-7 60815
15
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
16
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
17
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
18
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
19
Ethinyl Estradiol Approved Phase 4,Phase 3 57-63-6 5991
20
Moxifloxacin Approved, Investigational Phase 4,Phase 3 151096-09-2, 354812-41-2 152946
21
Norgestimate Approved, Investigational Phase 4,Phase 3 35189-28-7 6540478
22
Cefdinir Approved Phase 4 91832-40-5 6915944
23
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
24
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
25
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
26
Acetaminophen Approved Phase 4,Phase 2,Phase 3 103-90-2 1983
27
Dextromethorphan Approved Phase 4 125-71-3 5362449 5360696
28
Ephedrine Approved Phase 4,Phase 2 299-42-3 9294
29
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
30
Pseudoephedrine Approved Phase 4,Phase 2 90-82-4 7028
31
Thrombin Approved, Investigational Phase 4
32
Telithromycin Approved Phase 4,Phase 3 191114-48-4 0 5462516
33
Omalizumab Approved, Investigational Phase 4,Phase 3,Phase 2 242138-07-4
34
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
35
Almotriptan Approved, Investigational Phase 4 154323-57-6, 181183-52-8 123606
36
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
37
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
38
Bacitracin Approved, Vet_approved Phase 4,Phase 2 1405-87-4 10909430 439542
39
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
40
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
41
Citalopram Approved Phase 4 59729-33-8 2771
42 Strawberry Approved, Nutraceutical Phase 4,Phase 3
43 Amoxicillin-Potassium Clavulanate Combination Phase 4,Phase 3
44 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
46 beta-Lactamase Inhibitors Phase 4,Phase 3
47 Clavulanic Acid Phase 4,Phase 3
48 Cefditoren pivoxil Phase 4
49 Cephalosporins Phase 4
50 Anti-Allergic Agents Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 354)

# Name Status NCT ID Phase Drugs
1 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
2 Study of Cefditoren Pivoxil in Treatment of Childhood With Acute Rhinosinusitis Unknown status NCT01553006 Phase 4 cefditoren pivoxil
3 Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery Unknown status NCT02110654 Phase 4 Montelukast;mometasone furoate nasal spray
4 Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis Completed NCT00396162 Phase 4 probiotic containing L.rhamnosus R0011 strain
5 The PIO II Study of In-office Placement of a Steroid-eluting Sinus Implant Completed NCT02668302 Phase 4
6 Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate Completed NCT02340000 Phase 4 standard dose amoxicillin/clavulanate;high dose amoxicillin/clavulanate
7 Azithromycin for Patients With Chronic Rhinosinusitis Failing Medical and Surgical Therapy Completed NCT02307825 Phase 4 Azithromycin;Placebo
8 Efficacy and Safety of Sinusitis Hevert SL Tablets Compared to Placebo in Adult Patients With Acute, Uncomplicated Rhinosinusitis Completed NCT02296814 Phase 4 Sinusitis Hevert SL Tablet;Placebo for Sinusitis Hevert SL Tablet
9 The Optimal Head Position for Distributing Topical Nasal Medication Using the Mucosal Atomization Device Completed NCT02079792 Phase 4
10 Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis Completed NCT01825408 Phase 4 Doxycycline;Azithromycin;Augmentin
11 Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery Completed NCT01706952 Phase 4 Cocaine;Adrenaline
12 Saline Irrigation After Surgery in Patients With Chronic Sinusitis Completed NCT01575223 Phase 4
13 Randomized Controlled Trial to Evaluate of Dexmedetomidine for the Effect on Operative Visibility in Patients Undergoing Endoscopic Sinus Surgery Completed NCT01569048 Phase 4 Propofol and dexmedetomidine;propofol and remifentanil
14 Medicated Punctured-Glove-Finger Spacer Study Completed NCT01420471 Phase 4 Triamcinolone
15 Systemic Methylprednisolone in Chronic Rhinosinusitis Completed NCT01205984 Phase 4 methylprednisolone
16 Sinuclean's Treatment Of Sinusitis' Symptoms Completed NCT00747747 Phase 4
17 Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox Completed NCT00668304 Phase 4 Avelox (Moxifloxacin, BAY12-8039)
18 Study of the Safety and Efficacy of Cefdinir and Levofloxacin for the Treatment of Subjects With Acute Bacterial Sinusitis Completed NCT00645073 Phase 4 cefdinir (Omnicef);levofloxacin
19 Study to Evaluate Safety and Effectiveness of AdvaCoat Sinus Gel Completed NCT00554190 Phase 4
20 Treatment of Acute Sinusitis Completed NCT00377403 Phase 4 Acetaminophen;Amoxicillin;Dextromethorphan hydrobromide with guaifenesin;Guaifenesin;Pseudoephedrine Sustained Action;Saline spray (0.65%)
21 Zmax Compared to Augmentin in Sinusitis Completed NCT00367120 Phase 4 Azithromycin Extended Release;Amoxicillin/Clavulanate
22 Hemostatic Matrix in Endoscopic Sinus Surgery Completed NCT00242437 Phase 4
23 CHOOSE : Telithromycin, Acute Bacterial Sinusitis Completed NCT00174694 Phase 4 Telithromycin
24 Comparison Study Between Cefdinir & Amoxicilline/Clavulanate in Acute Sinusitis and Assessment of Quality of Life Completed NCT00147914 Phase 4 Cefdinir (drug);amoxicillin/clavulanate
25 The Impact Of The Addition Of Budesonide To Low-Pressure, High-Volume Saline Sinus Irrigation For Chronic Rhinosinusitis Completed NCT02696850 Phase 4 Budesonide;Saline alone
26 Xolair in Patients With Chronic Sinusitis Completed NCT00117611 Phase 4 Anti-IgE antibody omalizumab or placebo
27 Omeprazole 20 mg in Patients With Laryngopharyngeal reflux and Comorbid Chronic Rhinosinusitis Completed NCT03086070 Phase 4 Omeprazole 20mg;Placebo oral capsule
28 Study of Asthma and Nasal Steroids Completed NCT01118312 Phase 4 Mometasone Furoate monohydrate
29 Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers Completed NCT00208065 Phase 4 almotriptan or pseudoephedrine
30 Total Intravenous Anesthesia in Sinus Surgery Recruiting NCT02578862 Phase 4 Propofol;Sevoflurane
31 The Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis and Recurrent Sinusitis Recruiting NCT02582099 Phase 4 Gentamicin nasal irrigation;Normal saline nasal irrigation
32 Systemic Corticosteroids in the Perioperative Management of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) Recruiting NCT02119273 Phase 4 Prednisone;Placebo
33 Response of the Airway in Sinusitis and Asthma Recruiting NCT03011632 Phase 4 Mometasone Nasal;placebo mometasone
34 Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study Active, not recruiting NCT00841802 Phase 4 Prednisone
35 Prophylactic Antibiotics After Functional Endoscopic Sinus Surgery: a Randomized, Double-blind Placebo Controlled Trial Active, not recruiting NCT01919411 Phase 4 Amoxicillin-Potassium Clavulanate;Placebo
36 Treatment of Acute Sinusitis With High-Dose vs. Standard-Dose Amoxicillin/Clavulanate Not yet recruiting NCT03431337 Phase 4 Amoxicillin 875 mg
37 Use of Perioperative Antibiotics in Endoscopic Sinus Surgery Not yet recruiting NCT03369717 Phase 4 Amoxi Clavulanate
38 Canadian Health Economics, Outcome, and Effectiveness Comparison of Treatment in Patients With Chronic Rhinosinusitis Terminated NCT01455948 Phase 4
39 Corticosteroid Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) Terminated NCT01676415 Phase 4 Prednisone;Topical mometasone
40 Study of the Use of LUMA Lightwire Terminated NCT00705237 Phase 4
41 Study to Evaluate the Efficacy and Safety of Moxifloxacin Versus Amoxicillin/Clavulanate in the Treatment of Acute Bacterial Rhinosinusitis Terminated NCT00493038 Phase 4 Moxifloxacin (Avelox, BAY12-8039);Amoxicillin/Clavulanate
42 Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis Terminated NCT00245440 Phase 4 Azithromycin;Telithromycin
43 Sinusitis and Facial Pain Disorders Anti-Depression Trial Terminated NCT00754793 Phase 4 escitalopram;placebo
44 Nasospore Stent For Use in Enodscopic Sinus Surgery Withdrawn NCT00671541 Phase 4 Merogel Nasal Stent and Nasopore Stent;Nasopore Stent and either Gentamycin or Bacitracin
45 Effects of Anti-IgE Antibody Omalizumab on Patients With Chronic Sinusitis Withdrawn NCT00603785 Phase 4 Placebo;Xolair
46 Mitomicin C for Prevention Postoperative Endoscopic Sinus Surgery Synechia and QOL in Chronic Rhinosinusitis Unknown status NCT02106793 Phase 3 Mitomicin C;Identical placebo solution
47 The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery Unknown status NCT00852410 Phase 3 1% lidocaine with 1:100,000 adrenaline;1% lidocaine with 1:200,000 adrenaline
48 Prednisone in Chronic Rhinosinusitis Without Nasal Polyps Unknown status NCT02367118 Phase 3 Prednisone;Placebo
49 The Effect of RF Turbinoplasty in Polypoid Change of Middle Turbinates Unknown status NCT01906697 Phase 3
50 A Study of Luffa Operculate Nasal Solution 5mg/mL Compared With Saline (NaCl 09%) for the Relief of Nasal Obstruction Unknown status NCT01248325 Phase 3 Luffa Operculate Nasal Solution 5mg/mL;Saline Solution (NaCl 0,9%)

Search NIH Clinical Center for Paranasal Sinus Disease

Cochrane evidence based reviews: paranasal sinus diseases

Genetic Tests for Paranasal Sinus Disease

Anatomical Context for Paranasal Sinus Disease

MalaCards organs/tissues related to Paranasal Sinus Disease:

38
Eye, Bone, Lung, Colon, Breast, Liver, Kidney

Publications for Paranasal Sinus Disease

Articles related to Paranasal Sinus Disease:

(show all 49)
# Title Authors Year
1
Paranasal Sinus Disease in Children With Headache. ( 28831857 )
2017
2
Higher Body Mass Index and Increased Prevalence of Paranasal Sinus Disease. ( 26830349 )
2016
3
Pretransplant paranasal sinus disease is associated with a high incidence of transplant-related mortality in hematopoietic stem cell transplantation for children and adolescents. ( 27748554 )
2016
4
Association between diabetes and increased prevalence of paranasal sinus disease: a cross-sectional study in Japanese adults. ( 25728620 )
2015
5
A stereological study on the correlation of inferior turbinate hypertrophy and paranasal sinus disease. ( 24389985 )
2014
6
Headaches caused by nasal and paranasal sinus disease. ( 24703542 )
2014
7
The impact of a patient's age on the clinical presentation of inflammatory paranasal sinus disease. ( 23702318 )
2013
8
Prognosis for sixth nerve palsy arising from paranasal sinus disease. ( 24119609 )
2013
9
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): treatments and long-term results of treatments. ( 21812808 )
2012
10
Ophthalmic manifestations of paranasal sinus disease: a clinical grading system. ( 22411699 )
2012
11
Clinical consensus statement: appropriate use of computed tomography for paranasal sinus disease. ( 23054429 )
2012
12
Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): ancillary diagnostic findings and involvement of the various sinus compartments. ( 21812807 )
2012
13
Complications of nose and paranasal sinus disease. ( 23272436 )
2011
14
The expression of fibrinolytic components in chronic paranasal sinus disease. ( 21711960 )
2011
15
Paranasal sinus disease in horses. ( 21870345 )
2011
16
Paranasal sinus disease and sputum eosinophilia in prednisone-dependent asthma. ( 21144367 )
2010
17
Thyroid Eye Disease and Paranasal Sinus Disease. ( 20924307 )
2010
18
Significance of blood-tinged post-nasal drip in paranasal sinus disease. ( 17888198 )
2008
19
T-cell regulation in chronic paranasal sinus disease. ( 18423831 )
2008
20
The incidence of concha bullosa and its relationship to nasal septal deviation and paranasal sinus disease. ( 15502150 )
2004
21
Headaches due to nasal and paranasal sinus disease. ( 15062525 )
2004
22
The role of leukotriene inhibitors in patients with paranasal sinus disease. ( 12923360 )
2003
23
CT characterization of inflammatory paranasal sinus disease in cystic fibrosis. ( 11972457 )
2002
24
Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. ( 11195032 )
2000
25
Use of standard radiography to diagnose paranasal sinus disease of asthmatic children in Taiwan: comparison with computed tomography. ( 10466541 )
1999
26
Optic nerve blindness due to paranasal sinus disease. ( 10420111 )
1999
27
[Cytokines and chemokines in paranasal sinus diseases]. ( 10535064 )
1999
28
Relative value of MR imaging as compared with CT in the diagnosis of inflammatory paranasal sinus disease. ( 9885603 )
1999
29
Imaging of paranasal sinus disease. ( 9168874 )
1997
30
Imaging in paranasal sinus disease. ( 9619203 )
1997
31
Correlation of clinical examination with computer tomography in paranasal sinus disease. ( 9209590 )
1997
32
Paranasal sinus disease in patients with cystic fibrosis. ( 8834282 )
1996
33
Malignant plasmacytoma appearing as invasive paranasal sinus disease after cardiac transplantation. ( 8883660 )
1996
34
Efficacy of systemic corticosteroid treatment for anosmia with nasal and paranasal sinus disease. ( 8560170 )
1995
35
Nasal and paranasal sinus disease in patients with congenital velopharyngeal insufficiency. ( 8049050 )
1994
36
Paranasal sinus disease in HIV antibody positive patients. ( 8335314 )
1993
37
The prevalence of paranasal sinus disease in HIV infection and AIDS on cranial MR imaging. ( 8472478 )
1993
38
Inflammatory paranasal sinus disease in Bell's palsy demonstrated by magnetic resonance imaging. ( 8372929 )
1993
39
Effect of a topical vasoconstrictor on computed tomography of paranasal sinus disease. ( 8421421 )
1993
40
Endoscopic examination and treatment of paranasal sinus disease in 16 horses. ( 8116208 )
1993
41
Limited-slice CT in the evaluation of paranasal sinus disease in children. ( 1898816 )
1991
42
Paranasal sinus disease with intracranial extension: aspergillosis versus malignancy. ( 3131605 )
1988
43
Computed tomography in nasal and paranasal sinus disease. ( 6482629 )
1984
44
Comparison between transillumination and the roentgenogram in diagnosing paranasal sinus disease. ( 7451769 )
1981
45
Enzyme therapy in the triad of paranasal sinus disease, allergic asthmatic bronchitis, and bronchiectasis. ( 14446650 )
1959
46
The changing years: their impact upon the management of paranasal sinus disease. ( 13583895 )
1958
47
The changing years: their impact upon the management of paranasal sinus disease. ( 13647565 )
1958
48
Chronic paranasal sinus disease in adults; factors influencing treatment. ( 18124358 )
1949
49
Modern trends in diagnosis and treatment of paranasal sinus disease with particular reference to allergic manifestations. ( 20261616 )
1947

Variations for Paranasal Sinus Disease

Expression for Paranasal Sinus Disease

Search GEO for disease gene expression data for Paranasal Sinus Disease.

Pathways for Paranasal Sinus Disease

Pathways related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 ALOX5 CD79A GATA3 IFNG IL10 IL13
2
Show member pathways
13.63 ALOX5 IFNG IL10 IL13 IL17A IL4
3
Show member pathways
13.35 ALOX5 GATA3 IFNG IL10 IL13 IL17A
4
Show member pathways
13.28 FLNC IL10 IL13 IL17A IL4 IL5
5
Show member pathways
12.85 IFNG IL10 IL13 IL17A IL4 IL5
6 12.82 IFNG IL13 IL4 IL5 TGFB1
7
Show member pathways
12.59 ALOX5 CD79A IL13 IL4 IL5
8 12.57 ALOX5 CD79A GATA3 IFNG IL10 IL17A
9
Show member pathways
12.57 GATA3 IFNG IL10 IL13 IL17A IL4
10
Show member pathways
12.49 IFNG IL10 SERPINE1 TGFB1
11
Show member pathways
12.43 GATA3 IFNG IL10 IL17A IL4 IL5
12
Show member pathways
12.38 IFNG IL10 IL13 IL4 IL5
13
Show member pathways
12.35 IFNG IL13 IL17A IL4 IL5 MUC5B
14
Show member pathways
12.32 ALOX5 IFNG IL4 SERPINE1
15 12.29 FLNC PLAU PLAUR TGFB1
16
Show member pathways
12.29 ALOX5 IFNG IL10 IL4 TGFB1
17
Show member pathways
12.18 IFNG IL10 IL13 IL17A IL4 IL5
18 12.02 CD79A IFNG IL10 IL4 IL5
19 11.97 IFNG PLAU SERPINE1 TGFB1
20 11.96 IFNG IL4 TGFB1
21
Show member pathways
11.96 GATA3 IFNG IL10 IL17A TGFB1
22 11.92 ALOX5 GATA3 IL10 IL13 IL17A IL4
23
Show member pathways
11.9 IFNG IL17A IL4 TGFB1
24 11.86 IFNG IL10 TGFB1
25 11.84 GATA3 IFNG IL13 IL4 IL5
26 11.83 IFNG IL17A TGFB1
27 11.82 GATA3 IL10 IL5 SERPINE1
28
Show member pathways
11.8 GATA3 IFNG IL4 IL5
29 11.74 IFNG IL10 TGFB1
30 11.73 IL10 IL4 IL5 TGFB1
31 11.66 IL10 IL4 IL5
32 11.64 PLAU PLAUR SERPINE1
33 11.64 IL13 IL4 IL5 MUC5B PLAU TGFB1
34 11.62 IFNG SERPINE1 TGFB1
35 11.6 GATA3 IFNG IL10 IL13 IL17A IL4
36 11.54 IL10 IL13 IL4
37 11.53 IFNG IL10 TGFB1
38 11.4 GATA3 IFNG IL10 IL13 IL4 IL5
39
Show member pathways
11.39 IFNG IL10 TGFB1
40 11.35 IFNG IL4 IL5
41 11.27 IFNG IL13 TGFB1
42 11.24 IL10 IL13 IL17A IL4 IL5
43 11.22 IFNG IL10 IL13 IL4 IL5
44 11.04 GATA3 IL4 TGFB1
45 11.03 IL10 IL13 IL17A IL4 IL5 TGFB1
46 10.94 GATA3 IFNG IL13 IL17A IL4 IL5
47 10.88 PLAU PLAUR SERPINE1
48 10.84 IL13 IL4 IL5 TGFB1
49 10.58 IFNG IL10 IL13 IL4 IL5 TGFB1

GO Terms for Paranasal Sinus Disease

Cellular components related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ALOX5 IFNG IL10 IL13 IL17A IL4
2 extracellular space GO:0005615 9.36 ALOX5 IFNG IL10 IL13 IL17A IL4

Biological processes related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.96 GATA3 IL10 IL4 IL5 TGFB1
2 immune response GO:0006955 9.8 IFNG IL10 IL13 IL17A IL4 IL5
3 movement of cell or subcellular component GO:0006928 9.71 IFNG IL13 PLAUR
4 B cell differentiation GO:0030183 9.69 CD79A IL10 IL4
5 inflammatory response GO:0006954 9.63 ALOX5 IL10 IL13 IL17A IL5 TGFB1
6 positive regulation of T cell differentiation GO:0045582 9.61 GATA3 IL4
7 myeloid dendritic cell differentiation GO:0043011 9.61 IL4 TGFB1
8 positive regulation of macrophage activation GO:0043032 9.6 IL10 IL13
9 positive regulation of transcription regulatory region DNA binding GO:2000679 9.59 GATA3 TGFB1
10 cell activation GO:0001775 9.58 GATA3 TGFB1
11 regulation of regulatory T cell differentiation GO:0045589 9.58 IFNG TGFB1
12 positive regulation of B cell proliferation GO:0030890 9.58 IL13 IL4 IL5
13 negative regulation of interleukin-17 production GO:0032700 9.55 IFNG TGFB1
14 positive regulation of interleukin-13 production GO:0032736 9.52 GATA3 IL4
15 positive regulation of MHC class II biosynthetic process GO:0045348 9.49 IL10 IL4
16 type 2 immune response GO:0042092 9.48 IL10 IL4
17 positive regulation of interleukin-23 production GO:0032747 9.46 IFNG IL17A
18 regulation of isotype switching GO:0045191 9.43 IL10 IL4
19 fibrinolysis GO:0042730 9.43 PLAU PLAUR SERPINE1
20 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL13 IL4
21 negative regulation of endothelial cell apoptotic process GO:2000352 9.35 GATA3 IL10 IL13 IL4 SERPINE1
22 regulation of receptor activity GO:0010469 9.28 IFNG IL10 IL13 IL17A IL4 IL5
23 positive regulation of transcription by RNA polymerase II GO:0045944 10.04 GATA3 IL10 IL17A IL4 SERPINE1 TGFB1

Molecular functions related to Paranasal Sinus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.86 ALOX5 CD79A FLNC GATA3 IFNG IL10
2 growth factor activity GO:0008083 9.46 IL10 IL4 IL5 TGFB1
3 cytokine activity GO:0005125 9.17 IFNG IL10 IL13 IL17A IL4 IL5

Sources for Paranasal Sinus Disease

3 CDC
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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