MCID: PRN033
MIFTS: 23

Paraneoplastic Neurologic Disorders

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Paraneoplastic Neurologic Disorders

MalaCards integrated aliases for Paraneoplastic Neurologic Disorders:

Name: Paraneoplastic Neurologic Disorders 50
Pnd 50

Classifications:



Summaries for Paraneoplastic Neurologic Disorders

NIH Rare Diseases : 50 paraneoplastic neurologic disorders are a group of rare degenerative conditions that are triggered by a person's immune system response to a cancerous tumor. researchers believe these disorders occur when cancer-fighting antibodies or white blood cells known as t cells mistakenly attack normal cells in the nervous system. paraneoplastic neurologic disorders typically develop after mid-adulthood and are most common in people with lung, ovarian, lymphatic, or breast cancer. symptoms generally develop over a period of days to weeks and usually occur prior to tumor detection. these symptoms may include difficulty in walking and/or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo. paraneoplastic neurologic disorders include lambert-eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis (inflammation of the brain and spinal cord), myasthenia gravis, cerebellar degeneration, limbic and/or brainstem encephalitis, neuromyotonia, and opsoclonus (involving eye movement) and sensory neuropathy. treatment involves treatment of the underlying tumor, immunotherapy, and supportive therapy. last updated: 6/9/2016

MalaCards based summary : Paraneoplastic Neurologic Disorders, also known as pnd, is related to stiff-person syndrome and lung cancer. An important gene associated with Paraneoplastic Neurologic Disorders is AP3B2 (Adaptor Related Protein Complex 3 Beta 2 Subunit). The drugs Mitoxantrone and Interferon beta-1a have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and brain, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Paraneoplastic Neurologic Disorders

Diseases related to Paraneoplastic Neurologic Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 stiff-person syndrome 10.8
2 lung cancer 9.8
3 neuronitis 9.8
4 encephalitis 9.6
5 limbic encephalitis 9.6
6 parathyroid cancer, childhood 9.5 ELAVL4 ZIC1
7 autoimmune pancreatitis type 1 9.3 ZIC1 ZIC4
8 distal monosomy 12p 9.1 ZIC1 ZIC4
9 parkinson disease type 3 8.4 AP3B2 ELAVL4 ZIC1 ZIC4

Graphical network of the top 20 diseases related to Paraneoplastic Neurologic Disorders:



Diseases related to Paraneoplastic Neurologic Disorders

Symptoms & Phenotypes for Paraneoplastic Neurologic Disorders

MGI Mouse Phenotypes related to Paraneoplastic Neurologic Disorders:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.26 AP3B2 ELAVL4 ZIC1 ZIC4
2 nervous system MP:0003631 8.92 AP3B2 ELAVL4 ZIC1 ZIC4

Drugs & Therapeutics for Paraneoplastic Neurologic Disorders

Drugs for Paraneoplastic Neurologic Disorders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
2
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
3 Peripheral Nervous System Agents Phase 4,Phase 3
4 Analgesics Phase 4
5 Topoisomerase Inhibitors Phase 4
6 Adjuvants, Immunologic Phase 4
7 Anti-Infective Agents Phase 4
8 Antiviral Agents Phase 4
9 Interferon-beta Phase 4
10 interferons Phase 4
11
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
12
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
13 Antiemetics Phase 3
14 Anti-Inflammatory Agents Phase 3
15 Autonomic Agents Phase 3
16 Gastrointestinal Agents Phase 3
17 glucocorticoids Phase 3,Phase 1
18 Hormone Antagonists Phase 3,Phase 1
19 Hormones Phase 3,Phase 1
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
21 Methylprednisolone acetate Phase 3
22 Methylprednisolone Hemisuccinate Phase 3
23 Neuroprotective Agents Phase 3
24 Prednisolone acetate Phase 3
25 Prednisolone hemisuccinate Phase 3
26 Prednisolone phosphate Phase 3
27 Protective Agents Phase 3
28
4-Aminopyridine Approved Phase 2 504-24-5 1727
29
rituximab Approved Phase 2 174722-31-7 10201696
30 Potassium Channel Blockers Phase 2
31 Antirheumatic Agents Phase 2
32 Autoantibodies Phase 2
33 Antibodies Phase 2,Phase 1
34 gamma-Globulins Phase 2
35 Immunoglobulins Phase 2,Phase 1
36 Immunoglobulins, Intravenous Phase 2
37 Rho(D) Immune Globulin Phase 2
38 Antibodies, Monoclonal Phase 1
39
Prednisone Approved, Vet_approved 53-03-2 5865
40
Tacrolimus Approved, Investigational 104987-11-3 445643 439492
41
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
42
Diflunisal Approved 22494-42-4 3059
43 Calcineurin Inhibitors
44 Immunosuppressive Agents
45 Analgesics, Non-Narcotic
46 Anti-Inflammatory Agents, Non-Steroidal
47 Cyclooxygenase Inhibitors
48 3,4-diaminopyridine

Interventional clinical trials:

(show all 18)

id Name Status NCT ID Phase Drugs
1 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease) Completed NCT00304291 Phase 4 Mitoxantrone
2 Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis Completed NCT00179478 Phase 4 interferon beta 1a 30 ug IM once weekly
3 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
4 MC-5A for Chemotherapy Induced Peripheral Neuropathy Completed NCT01261780 Phase 2 Sham device
5 Immunotherapy and Paraneoplastic Neurological Syndromes Active, not recruiting NCT02343211 Phase 2 Immunoglobulin
6 Safety and Efficacy of Sustained Release Dalfampridine in Transverse Myelitis (Re-Launch) Active, not recruiting NCT02166346 Phase 2 Dalfampridine;Placebo
7 Immunoadsorption Therapy in Managing NMDAR Antibodies Encephalitis Not yet recruiting NCT03274375 Phase 2 IA session;Rituximab
8 IVIG Treatment for Refractory Immune-Related Adult Epilepsy Terminated NCT01545518 Phase 2 IVIG
9 Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses Active, not recruiting NCT02276963 Phase 1 Ublituximab
10 Immunotherapy of the Paraneoplastic Syndromes Completed NCT00378326 Tacrolimus
11 Prevalence+Significance of Paraneoplastic Autoantibodies in Many Cancers Completed NCT00608452
12 Study of Cytokines in Children With Opsoclonus-Myoclonus Syndrome Completed NCT00806182
13 The Effect of Diflunisal on Familial Transthyretin Amyloidosis Completed NCT01432587 Diflunisal
14 Randomized Study of 3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome Completed NCT00004832 3,4-diaminopyridine
15 The Study of Immune Cell (T Cell) Activity in Patients With Paraneoplastic Neurologic Syndromes Recruiting NCT00327236
16 Biobank For MS And Other Demyelinating Diseases Active, not recruiting NCT00445367
17 Serum Auto-Antibodies in Neurological Diseases Enrolling by invitation NCT00704626
18 Treatment of Lambert-Eaton Myasthenic Syndrome (LEMS) With 3, 4 DAP No longer available NCT01378546 3,4-diaminopyridine

Search NIH Clinical Center for Paraneoplastic Neurologic Disorders

Genetic Tests for Paraneoplastic Neurologic Disorders

Anatomical Context for Paraneoplastic Neurologic Disorders

MalaCards organs/tissues related to Paraneoplastic Neurologic Disorders:

39
T Cells, Lung, Brain, Spinal Cord, Eye, Testis

Publications for Paraneoplastic Neurologic Disorders

Articles related to Paraneoplastic Neurologic Disorders:

(show all 19)
id Title Authors Year
1
Paraneoplastic neurologic disorders in small cell lung carcinoma: A prospective study. ( 26109714 )
2015
2
Diagnosis and management of paraneoplastic neurologic disorders. ( 23900965 )
2013
3
Paraneoplastic Neurologic Disorders: A Brief Overview. ( 23264806 )
2012
4
Paraneoplastic neurologic disorders in children. ( 21161703 )
2011
5
Update on paraneoplastic neurologic disorders. ( 21572897 )
2010
6
Update on paraneoplastic neurologic disorders. ( 20479279 )
2010
7
Treatment of paraneoplastic neurologic disorders. ( 20842583 )
2010
8
Positron emission tomography-computed tomography in paraneoplastic neurologic disorders: systematic analysis and review. ( 20065123 )
2010
9
Clinical and immunological diversity of limbic encephalitis: a model for paraneoplastic neurologic disorders. ( 17113466 )
2006
10
Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. ( 15477575 )
2004
11
Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. ( 15007130 )
2004
12
Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity. ( 14732616 )
2004
13
Spectrum of paraneoplastic neurologic disorders in women with breast and gynecologic cancer. ( 12792307 )
2003
14
The importance of defining the paraneoplastic neurologic disorders. ( 10362830 )
1999
15
Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. ( 10050892 )
1999
16
Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. ( 9344654 )
1997
17
Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain. ( 8643438 )
1996
18
Immune modulation of paraneoplastic neurologic disorders. ( 7788966 )
1995
19
Clinical enigmas of paraneoplastic neurologic disorders. ( 7788978 )
1995

Variations for Paraneoplastic Neurologic Disorders

Expression for Paraneoplastic Neurologic Disorders

Search GEO for disease gene expression data for Paraneoplastic Neurologic Disorders.

Pathways for Paraneoplastic Neurologic Disorders

GO Terms for Paraneoplastic Neurologic Disorders

Sources for Paraneoplastic Neurologic Disorders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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