PND
MCID: PRN033
MIFTS: 31

Paraneoplastic Neurologic Disorders (PND) malady

Rare diseases, Neuronal diseases categories

Summaries for Paraneoplastic Neurologic Disorders

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44NIH Rare Diseases, 34MalaCards
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NIH Rare Diseases:44 Paraneoplastic neurologic disorders are a group of rare degenerative conditions that are triggered by a person's immune system response to a cancerous tumor.Ā researchers believe theseĀ disorders occur when cancer-fighting antibodies or white blood cells known as t cells mistakenly attack normal cells in the nervous system. paraneoplastic neurologic disorders typically develop after mid-adulthood and are most common in people with lung, ovarian, lymphatic, or breast cancer. symptoms generally develop over a period of days to weeks and usually occur prior to tumor detection. these symptoms may include difficulty in walking and/or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo. paraneoplastic neurologic disorders include lambert-eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis (inflammation of the brain and spinal cord), myasthenia gravis, cerebellar degeneration, limbic and/or brainstem encephalitis, neuromyotonia, and opsoclonus (involving eye movement) and sensory neuropathy. last updated: 11/25/2008

MalaCards: Paraneoplastic Neurologic Disorders, also known as dyspnea, paroxysmal, is related to neuronitis and lung cancer. An important gene associated with Paraneoplastic Neurologic Disorders is CDR1 (cerebellar degeneration-related protein 1, 34kDa). The drugs nesiritide and nesiritide recombinant have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and breast, and related mouse phenotypes are mortality/aging and nervous system.

Aliases & Classifications for Paraneoplastic Neurologic Disorders

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

paraneoplastic neurologic disorders 44
dyspnea, paroxysmal 63
pnd 44


Related Diseases for Paraneoplastic Neurologic Disorders

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18GeneCards, 19GeneDecks
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Diseases related to Paraneoplastic Neurologic Disorders via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1neuronitis10.3
2lung cancer10.3
3stiff-person syndrome10.1
4encephalitis10.1
5limbic encephalitis10.1
6hiv1 infection10.1
7paraneoplastic cerebellar degeneration10.1CDR2
8cerebellar degeneration10.1CDR2
9blepharophimosis, ptosis, and epicanthus inversus syndrome type 110.0ZIC4, ZIC1
10medulloblastoma10.0ZIC1, ELAVL4
11paraneoplastic syndromes9.9ELAVL4, DAZL

Graphical network of diseases related to Paraneoplastic Neurologic Disorders:



Diseases related to paraneoplastic neurologic disorders

Symptoms for Paraneoplastic Neurologic Disorders

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Drugs & Therapeutics for Paraneoplastic Neurologic Disorders

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Paraneoplastic Neurologic Disorders

Drug clinical trials:

Search ClinicalTrials for Paraneoplastic Neurologic Disorders

Search NIH Clinical Center for Paraneoplastic Neurologic Disorders

Search CenterWatch for Paraneoplastic Neurologic Disorders

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Paraneoplastic Neurologic Disorders

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Anatomical Context for Paraneoplastic Neurologic Disorders

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34MalaCards
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MalaCards organs/tissues related to Paraneoplastic Neurologic Disorders:

34
Lung, Brain, Breast, Eye, Spinal cord, T cells, Testis

Animal Models for Paraneoplastic Neurologic Disorders or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Paraneoplastic Neurologic Disorders:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.7ELAVL4, ZIC1, ZIC4, NOVA1, NOVA2
2MP:00036317.4ELAVL4, ZIC1, ZIC4, NOVA1, NOVA2

Publications for Paraneoplastic Neurologic Disorders

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53PubMed
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Articles related to Paraneoplastic Neurologic Disorders:

(show all 17)
idTitleAuthorsYear
1
Diagnosis and management of paraneoplastic neurologic disorders. (23900965)
2013
2
Paraneoplastic Neurologic Disorders: A Brief Overview. (23264806)
2012
3
Paraneoplastic neurologic disorders in children. (21161703)
2011
4
Update on paraneoplastic neurologic disorders. (21572897)
2010
5
Positron emission tomography-computed tomography in paraneoplastic neurologic disorders: systematic analysis and review. (20065123)
2010
6
Update on paraneoplastic neurologic disorders. (20479279)
2010
7
Treatment of paraneoplastic neurologic disorders. (20842583)
2010
8
Clinical and immunological diversity of limbic encephalitis: a model for paraneoplastic neurologic disorders. (17113466)
2006
9
Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. (15007130)
2004
10
Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity. (14732616)
2004
11
Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. (15477575)
2004
12
Spectrum of paraneoplastic neurologic disorders in women with breast and gynecologic cancer. (12792307)
2003
13
Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. (10050892)
1999
14
Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. (9344654)
1997
15
Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain. (8643438)
1996
16
Clinical enigmas of paraneoplastic neurologic disorders. (7788978)
1995
17
Immune modulation of paraneoplastic neurologic disorders. (7788966)
1995

Variations for Paraneoplastic Neurologic Disorders

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Expression for genes affiliated with Paraneoplastic Neurologic Disorders

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paraneoplastic Neurologic Disorders

Search GEO for disease gene expression data for Paraneoplastic Neurologic Disorders.

Pathways for genes affiliated with Paraneoplastic Neurologic Disorders

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Compounds for genes affiliated with Paraneoplastic Neurologic Disorders

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GO Terms for genes affiliated with Paraneoplastic Neurologic Disorders

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17Gene Ontology
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Biological processes related to Paraneoplastic Neurologic Disorders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA processingGO:0063969.1NOVA1, ELAVL4

Molecular functions related to Paraneoplastic Neurologic Disorders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mRNA 3-UTR bindingGO:0037309.3ELAVL4, DAZL
2RNA bindingGO:0037237.8NOVA2, NOVA1, ELAVL4, DAZL

Products for genes affiliated with Paraneoplastic Neurologic Disorders

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  • Antibodies
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  • Antibodies

Sources for Paraneoplastic Neurologic Disorders

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet