PND
MCID: PRN033
MIFTS: 23

Paraneoplastic Neurologic Disorders (PND) malady

Neuronal diseases category

Summaries for Paraneoplastic Neurologic Disorders

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Paraneoplastic neurologic disorders are a group of rare degenerative conditions that are triggered by a person's immune system response to a cancerous tumor. researchers believe these disorders occur when cancer-fighting antibodies or white blood cells known as t cells mistakenly attack normal cells in the nervous system. paraneoplastic neurologic disorders typically develop after mid-adulthood and are most common in people with lung, ovarian, lymphatic, or breast cancer. symptoms generally develop over a period of days to weeks and usually occur prior to tumor detection. these symptoms may include difficulty in walking and/or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo. paraneoplastic neurologic disorders include lambert-eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis (inflammation of the brain and spinal cord), myasthenia gravis, cerebellar degeneration, limbic and/or brainstem encephalitis, neuromyotonia, and opsoclonus (involving eye movement) and sensory neuropathy. last updated: 11/25/2008

MalaCards: Paraneoplastic Neurologic Disorders, also known as dyspnea, paroxysmal, is related to neuronitis and lung cancer. An important gene associated with Paraneoplastic Neurologic Disorders is CDR1 (cerebellar degeneration-related protein 1, 34kDa). The drugs nesiritide and nesiritide recombinant have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and spinal cord.

Aliases & Classifications for Paraneoplastic Neurologic Disorders

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42NIH Rare Diseases, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

paraneoplastic neurologic disorders 42
dyspnea, paroxysmal 60
pnd 42


Related Diseases for Paraneoplastic Neurologic Disorders

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17GeneCards, 18GeneDecks
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Diseases related to Paraneoplastic Neurologic Disorders via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1neuronitis10.2
2lung cancer10.2
3stiff-person syndrome10.1
4brain cancer10.1
5breast cancer10.1
6encephalitis10.1
7cerebellar degeneration10.0CDR2
8paraneoplastic cerebellar degeneration10.0CDR2
9dandy-walker syndrome10.0ZIC4, ZIC1
10paraneoplastic syndromes10.0ELAVL4, DAZL
11blepharophimosis, ptosis, and epicanthus inversus syndrome type 110.0ZIC4, ZIC1
12sensory peripheral neuropathy10.0ELAVL3, ELAVL4
13medulloblastoma10.0ELAVL4, ZIC1, ELAVL2, ELAVL1

Graphical network of diseases related to Paraneoplastic Neurologic Disorders:



Diseases related to paraneoplastic neurologic disorders

Clinical Features for Paraneoplastic Neurologic Disorders

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Drugs & Therapeutics for Paraneoplastic Neurologic Disorders

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Paraneoplastic Neurologic Disorders

Drug clinical trials:

Search ClinicalTrials for Paraneoplastic Neurologic Disorders

Search NIH Clinical Center for Paraneoplastic Neurologic Disorders

Search CenterWatch for Paraneoplastic Neurologic Disorders

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Paraneoplastic Neurologic Disorders

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Anatomical Context for Paraneoplastic Neurologic Disorders

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32MalaCards
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MalaCards organs/tissues related to Paraneoplastic Neurologic Disorders:

32
Eye, Brain, Spinal cord, Lung, Breast, T cells

Animal Models for Paraneoplastic Neurologic Disorders or affiliated genes

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Publications for Paraneoplastic Neurologic Disorders

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Genetic Variations for Paraneoplastic Neurologic Disorders

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Expression for genes affiliated with Paraneoplastic Neurologic Disorders

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paraneoplastic Neurologic Disorders

Search GEO for disease gene expression data for Paraneoplastic Neurologic Disorders.

Pathways for genes affiliated with Paraneoplastic Neurologic Disorders

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Compounds for genes affiliated with Paraneoplastic Neurologic Disorders

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GO Terms for genes affiliated with Paraneoplastic Neurologic Disorders

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Sources:
16Gene Ontology
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Molecular functions related to Paraneoplastic Neurologic Disorders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mRNA 3-UTR bindingGO:0037309.6ELAVL4, ELAVL2
2AU-rich element bindingGO:0170918.8ELAVL4, ELAVL3, ELAVL1
3nucleotide bindingGO:0001668.2DAZL, ELAVL1, ELAVL2, ELAVL3, ELAVL4
4RNA bindingGO:0037237.5ELAVL4, ELAVL1, NOVA1, NOVA2, DAZL

Products for genes affiliated with Paraneoplastic Neurologic Disorders

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Paraneoplastic Neurologic Disorders

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet