Paraneoplastic Neurologic Disorders malady

NIH Rare Diseases: Paraneoplastic neurologic disorders are a group of rare degenerative conditions that are triggered by a person's immune system response to a cancerous tumor. Researchers believe these disorders occur when cancer-fighting antibodies or white blood cells known as T cells mistakenly attack normal cells in the nervous system. Paraneoplastic neurologic disorders typically develop after mid-adulthood and are most common in people with lung, ovarian, lymphatic, or breast cancer. Symptoms generally develop over a period of days to weeks and usually occur prior to tumor detection. These symptoms may include difficulty in walking and/or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo. Paraneoplastic neurologic disorders include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis (inflammation of the brain and spinal cord), myasthenia gravis, cerebellar degeneration, limbic and/or brainstem encephalitis, neuromyotonia, and opsoclonus (involving eye movement) and sensory neuropathy.³⁰

MalaCards: Paraneoplastic Neurologic Disorders, also known as nervous system disorder, is related to neuronitis and blepharophimosis, ptosis, and epicanthus inversus syndrome. An important gene associated with Paraneoplastic Neurologic Disorders is PNMA1 (paraneoplastic Ma antigen 1). Affiliated tissues include brain, spinal cord and lung.

paraneoplastic neurologic disorders 30 nervous system disorder 43

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Diseases related to paraneoplastic neurologic disorders by text searches and GeneDecks gene sharing:

(show all 39)

id	Related Disease	Score	Top Affiliating Genes
1	neuronitis	22.4	ELAVL4, ELAVL3, ELAVL2, ELAVL1, NOVA2, NOVA1
2	blepharophimosis, ptosis, and epicanthus inversus syndrome	12.9	ZIC1, ZIC4
3	limbic encephalitis	12.9	ELAVL3, PNMA2
4	dandy-walker malformation	12.8	ZIC4, ZIC1
5	sensory peripheral neuropathy	12.6	ELAVL3, ELAVL4
6	myasthenic syndrome	12.6	ELAVL3, ELAVL4
7	lambert-eaton myasthenic syndrome	12.5	ELAVL3, ELAVL4
8	paraneoplastic cerebellar degeneration	12.4	ELAVL3, CDR2, CDR1, ZIC1
9	neurologic diseases	12.4	ELAVL4, PNMA3, PNMA2, PNMA1
10	paraneoplastic syndromes	12.2	ELAVL4, DAZL
11	cerebellar degeneration	11.8	ELAVL3, CDR2, CDR1, CDR3, ZIC4, ZIC1
12	medulloblastoma	11.0	ELAVL4, ELAVL2, ELAVL1, DAZL, ZIC1
13	encephalomyelitis	10.8	ELAVL4, ELAVL3, ELAVL2, ELAVL1, PNMA1, DAZL
14	autonomic nervous system disease	9.3
15	central nervous system cancer	6.8
16	horner's syndrome	6.8
17	myotonic dystrophy	6.8
18	pelizaeus-merzbacher disease	6.8
19	lung cancer	6.6
20	nervous system disease	5.9
21	oculopharyngeal muscular dystrophy	5.9
22	riley-day syndrome	5.9
23	venezuelan equine encephalitis	5.9
24	aids - neurological complications	5.9
25	autonomic dysfunction	5.9
26	bscl2-related neurologic disorders/seipinopathy	5.9
27	colpocephaly	5.9
28	central nervous system tuberculosis	5.9
29	canavan disease	5.9
30	dysautonomia	5.9
31	dysautonomia like disorder	5.9
32	nervous system cancer	5.9
33	pendred syndrome/dfnb4	5.6
34	pandas	5.6
35	familial melanoma	5.6
36	melanoma	5.6
37	neuroblastoma	5.6
38	pain disorder	5.6
39	pendred syndrome	5.6

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to paraneoplastic neurologic disorders:

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Articles related to paraneoplastic neurologic disorders:

id	Title	Authors	Year	Affiliating Genes
1	Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. (15007130)	Bataller L.... Dalmau J.	2004	ELAVL4, ZIC1, ZIC4
2	Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. (10050892)	Dalmau J.... Rosenfeld M.R.	1999	PNMA2, PNMA1
3	Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. (9344654)	Fletcher C.F.... Darnell R.B.	1997	DAZL, CDR2, NOVA2

Genes related to paraneoplastic neurologic disorders according to GeneCards:

(show all 15)

id	Symbol	Description	Score	GeneCards Section Context
1	PNMA1	paraneoplastic Ma antigen 1	11.1	Publications, Summaries
2	CDR3	Cerebellar degeneration-related autoantigen-3	11.0	Publications
3	CDR1	cerebellar degeneration-related protein 1, 34kDa	11.0	Functions
4	PNMA3	paraneoplastic Ma antigen 3	11.0	UniProt Related
5	PNMA2	paraneoplastic Ma antigen 2	11.0	Publications, UniProt Related
6	ZIC4	Zic family member 4	11.0	Publications
7	NOVA2	neuro-oncological ventral antigen 2	11.0	Publications
8	CDR2	cerebellar degeneration-related protein 2, 62kDa	11.0	Publications, Functions
9	ELAVL3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	11.0	Orthologs
10	ZIC1	Zic family member 1	11.0	Publications
11	DAZL	deleted in azoospermia-like	11.0	Publications
12	ELAVL4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4	11.0	Orthologs, Publications
13	NOVA1	neuro-oncological ventral antigen 1	11.0	Functions
14	ELAVL1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	11.0	Orthologs
15	ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	11.0	Orthologs

Molecular functions related to paraneoplastic neurologic disorders according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mRNA 3-UTR binding	GO:003730	8.9	ELAVL4, ELAVL2, DAZL
2	AU-rich element binding	GO:017091	8.8	ELAVL4, ELAVL3, ELAVL1
3	RNA binding	GO:003723	7.7	NOVA2, NOVA1, ELAVL4, DAZL, ELAVL1
4	nucleotide binding	GO:000166	7.5	DAZL, ELAVL4, ELAVL3, ELAVL2, ELAVL1