PND
MCID: PRN033
MIFTS: 26

Paraneoplastic Neurologic Disorders (PND) malady

Neuronal category

Summaries for Paraneoplastic Neurologic Disorders

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Paraneoplastic neurologic disorders are a group of rare degenerative conditions that are triggered by a person's immune system response to a cancerous tumor. researchers believe these disorders occur when cancer-fighting antibodies or white blood cells known as t cells mistakenly attack normal cells in the nervous system. paraneoplastic neurologic disorders typically develop after mid-adulthood and are most common in people with lung, ovarian, lymphatic, or breast cancer. symptoms generally develop over a period of days to weeks and usually occur prior to tumor detection. these symptoms may include difficulty in walking and/or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo. paraneoplastic neurologic disorders include lambert-eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis (inflammation of the brain and spinal cord), myasthenia gravis, cerebellar degeneration, limbic and/or brainstem encephalitis, neuromyotonia, and opsoclonus (involving eye movement) and sensory neuropathy. last updated: 11/25/2008

MalaCards: Paraneoplastic Neurologic Disorders, also known as dyspnea, paroxysmal, is related to stiff-person syndrome and brain cancer. An important gene associated with Paraneoplastic Neurologic Disorders is CDR1 (cerebellar degeneration-related protein 1, 34kDa). The drugs nesiritide and nesiritide recombinant have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and lung.

Aliases & Classifications for Paraneoplastic Neurologic Disorders

Sources:
43NIH Rare Diseases, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

paraneoplastic neurologic disorders 43
dyspnea, paroxysmal 61
pnd 43


Related Diseases for Paraneoplastic Neurologic Disorders

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Paraneoplastic Neurologic Disorders via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1stiff-person syndrome10.1
2brain cancer10.1
3limbic encephalitis10.1
4hiv1 infection10.0
5cerebellar degeneration10.0CDR2
6paraneoplastic cerebellar degeneration10.0CDR2
7dandy-walker syndrome10.0ZIC4, ZIC1
8paraneoplastic syndromes10.0DAZL, ELAVL4
9blepharophimosis, ptosis, and epicanthus inversus syndrome type 110.0ZIC4, ZIC1
10sensory peripheral neuropathy10.0ELAVL4, ELAVL3
11medulloblastoma10.0ZIC1, ELAVL1, ELAVL2, ELAVL4

Graphical network of diseases related to Paraneoplastic Neurologic Disorders:



Diseases related to paraneoplastic neurologic disorders

Clinical Features for Paraneoplastic Neurologic Disorders

Drugs & Therapeutics for Paraneoplastic Neurologic Disorders

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Paraneoplastic Neurologic Disorders

Drug clinical trials:

Search ClinicalTrials for Paraneoplastic Neurologic Disorders

Search NIH Clinical Center for Paraneoplastic Neurologic Disorders

Search CenterWatch for Paraneoplastic Neurologic Disorders

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Paraneoplastic Neurologic Disorders

Anatomical Context for Paraneoplastic Neurologic Disorders

Sources:
33MalaCards
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MalaCards organs/tissues related to Paraneoplastic Neurologic Disorders:

33
Brain, Spinal cord, Lung, Breast, Testis, T cells

Animal Models for Paraneoplastic Neurologic Disorders or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Paraneoplastic Neurologic Disorders

Sources:
51PubMed
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Articles related to Paraneoplastic Neurologic Disorders:

(show all 17)
idTitleAuthorsYear
1
Diagnosis and management of paraneoplastic neurologic disorders. (23900965)
2013
2
Paraneoplastic Neurologic Disorders: A Brief Overview. (23264806)
2012
3
Paraneoplastic neurologic disorders in children. (21161703)
2011
4
Update on paraneoplastic neurologic disorders. (21572897)
2010
5
Positron emission tomography-computed tomography in paraneoplastic neurologic disorders: systematic analysis and review. (20065123)
2010
6
Update on paraneoplastic neurologic disorders. (20479279)
2010
7
Treatment of paraneoplastic neurologic disorders. (20842583)
2010
8
Clinical and immunological diversity of limbic encephalitis: a model for paraneoplastic neurologic disorders. (17113466)
2006
9
Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. (15007130)
2004
10
Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity. (14732616)
2004
11
Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. (15477575)
2004
12
Spectrum of paraneoplastic neurologic disorders in women with breast and gynecologic cancer. (12792307)
2003
13
The importance of defining the paraneoplastic neurologic disorders. (10362830)
1999
14
Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. (10050892)
1999
15
Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain. (8643438)
1996
16
Clinical enigmas of paraneoplastic neurologic disorders. (7788978)
1995
17
Immune modulation of paraneoplastic neurologic disorders. (7788966)
1995

Genetic Variations for Paraneoplastic Neurologic Disorders

Expression for genes affiliated with Paraneoplastic Neurologic Disorders

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paraneoplastic Neurologic Disorders

Search GEO for disease gene expression data for Paraneoplastic Neurologic Disorders.

Pathways for genes affiliated with Paraneoplastic Neurologic Disorders

Compounds for genes affiliated with Paraneoplastic Neurologic Disorders

GO Terms for genes affiliated with Paraneoplastic Neurologic Disorders

Sources:
16Gene Ontology
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Molecular functions related to Paraneoplastic Neurologic Disorders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mRNA 3-UTR bindingGO:0037309.6ELAVL2, ELAVL4
2AU-rich element bindingGO:0170918.8ELAVL1, ELAVL3, ELAVL4
3nucleotide bindingGO:0001668.2ELAVL4, DAZL, ELAVL3, ELAVL1, ELAVL2
4RNA bindingGO:0037237.5ELAVL4, NOVA1, DAZL, NOVA2, ELAVL1

Products for genes affiliated with Paraneoplastic Neurologic Disorders

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Paraneoplastic Neurologic Disorders

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet