MCID: PRN033
MIFTS: 23

Paraneoplastic Neurologic Disorders

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Paraneoplastic Neurologic Disorders

MalaCards integrated aliases for Paraneoplastic Neurologic Disorders:

Name: Paraneoplastic Neurologic Disorders 49
Pnd 49

Classifications:



Summaries for Paraneoplastic Neurologic Disorders

NIH Rare Diseases : 49 Paraneoplastic neurologic disorders are a group of rare degenerative conditions that are triggered by a person's immune system response to a cancerous tumor. Researchers believe these disorders occur when cancer-fighting antibodies or white blood cells known as T cells mistakenly attack normal cells in the nervous system. Paraneoplastic neurologic disorders typically develop after mid-adulthood and are most common in people with lung, ovarian, lymphatic, or breast cancer. Symptoms generally develop over a period of days to weeks and usually occur prior to tumor detection. These symptoms may include difficulty in walking and/or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo. Paraneoplastic neurologic disorders include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis (inflammation of the brain and spinal cord), myasthenia gravis, cerebellar degeneration, limbic and/or brainstem encephalitis, neuromyotonia, and opsoclonus (involving eye movement) and sensory neuropathy. Treatment involves treatment of the underlying tumor, immunotherapy, and supportive therapy. Last updated: 6/9/2016

MalaCards based summary : Paraneoplastic Neurologic Disorders, also known as pnd, is related to stiff-person syndrome and human immunodeficiency virus type 1. An important gene associated with Paraneoplastic Neurologic Disorders is AP3B2 (Adaptor Related Protein Complex 3 Beta 2 Subunit). The drugs Tacrolimus and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and brain, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Paraneoplastic Neurologic Disorders

Diseases related to Paraneoplastic Neurologic Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 stiff-person syndrome 10.9
2 human immunodeficiency virus type 1 10.0
3 small cell cancer of the lung 9.8
4 lung cancer 9.8
5 neuronitis 9.8
6 encephalitis 9.7
7 limbic encephalitis 9.7
8 isolated dandy-walker malformation without hydrocephalus 9.5 ZIC1 ZIC4
9 isolated dandy-walker malformation with hydrocephalus 9.4 ZIC1 ZIC4
10 paraneoplastic cerebellar degeneration 9.4 ELAVL4 ZIC1

Graphical network of the top 20 diseases related to Paraneoplastic Neurologic Disorders:



Diseases related to Paraneoplastic Neurologic Disorders

Symptoms & Phenotypes for Paraneoplastic Neurologic Disorders

MGI Mouse Phenotypes related to Paraneoplastic Neurologic Disorders:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.26 AP3B2 ELAVL4 ZIC1 ZIC4
2 nervous system MP:0003631 8.92 ELAVL4 ZIC1 ZIC4 AP3B2

Drugs & Therapeutics for Paraneoplastic Neurologic Disorders

Drugs for Paraneoplastic Neurologic Disorders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational 104987-11-3 445643 439492
2
Prednisone Approved, Vet_approved 53-03-2 5865
3 Immunosuppressive Agents
4 Calcineurin Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunotherapy of the Paraneoplastic Syndromes Completed NCT00378326 Tacrolimus

Search NIH Clinical Center for Paraneoplastic Neurologic Disorders

Genetic Tests for Paraneoplastic Neurologic Disorders

Anatomical Context for Paraneoplastic Neurologic Disorders

MalaCards organs/tissues related to Paraneoplastic Neurologic Disorders:

38
Lung, Breast, Brain, T Cells, Eye, Spinal Cord, Testis

Publications for Paraneoplastic Neurologic Disorders

Articles related to Paraneoplastic Neurologic Disorders:

(show all 19)
# Title Authors Year
1
Paraneoplastic neurologic disorders in small cell lung carcinoma: A prospective study. ( 26109714 )
2015
2
Diagnosis and management of paraneoplastic neurologic disorders. ( 23900965 )
2013
3
Paraneoplastic Neurologic Disorders: A Brief Overview. ( 23264806 )
2012
4
Paraneoplastic neurologic disorders in children. ( 21161703 )
2011
5
Update on paraneoplastic neurologic disorders. ( 21572897 )
2010
6
Positron emission tomography-computed tomography in paraneoplastic neurologic disorders: systematic analysis and review. ( 20065123 )
2010
7
Treatment of paraneoplastic neurologic disorders. ( 20842583 )
2010
8
Update on paraneoplastic neurologic disorders. ( 20479279 )
2010
9
Clinical and immunological diversity of limbic encephalitis: a model for paraneoplastic neurologic disorders. ( 17113466 )
2006
10
Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. ( 15007130 )
2004
11
Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. ( 15477575 )
2004
12
Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity. ( 14732616 )
2004
13
Spectrum of paraneoplastic neurologic disorders in women with breast and gynecologic cancer. ( 12792307 )
2003
14
Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. ( 10050892 )
1999
15
The importance of defining the paraneoplastic neurologic disorders. ( 10362830 )
1999
16
Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. ( 9344654 )
1997
17
Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain. ( 8643438 )
1996
18
Clinical enigmas of paraneoplastic neurologic disorders. ( 7788978 )
1995
19
Immune modulation of paraneoplastic neurologic disorders. ( 7788966 )
1995

Variations for Paraneoplastic Neurologic Disorders

Expression for Paraneoplastic Neurologic Disorders

Search GEO for disease gene expression data for Paraneoplastic Neurologic Disorders.

Pathways for Paraneoplastic Neurologic Disorders

GO Terms for Paraneoplastic Neurologic Disorders

Sources for Paraneoplastic Neurologic Disorders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....