MCID: PRN039
MIFTS: 46

Paraneoplastic Syndromes malady

Summaries for Paraneoplastic Syndromes

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45NINDS, 66Wikipedia, 34MalaCards
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NINDS:45 Paraneoplastic syndromes are a group of rare disorders that are triggered by an abnormal immune system response to a cancerous tumor known as a "neoplasm." Paraneoplastic syndromes are thought to happen when cancer-fighting antibodies or white blood cells (known as T cells) mistakenly attack normal cells in the nervous system. These disorders typically affect middle-aged to older people and are most common in individuals with lung, ovarian, lymphatic, or breast cancer. Neurologic symptoms generally develop over a period of days to weeks and usually occur prior to the tumor being discovered. These symptoms may include difficulty in walking or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo or dizziness. Paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis, myasthenia gravis, cerebellar degeneration, limbic or brainstem encephalitis, neuromyotonia, opsoclonus, and sensory neuropathy.

MalaCards: Paraneoplastic Syndromes is related to hypercalcemia and osteomalacia. An important gene associated with Paraneoplastic Syndromes is FGF23 (fibroblast growth factor 23), and among its related pathways are amb2 Integrin signaling and PAK Pathway. The compounds 25-hydroxyvitamin d and octreotide have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and t cells, and related mouse phenotypes are limbs/digits/tail and reproductive system.

Wikipedia:66 A paraneoplastic syndrome is a disease or symptom that is the consequence of cancer in the body but,... more...

Aliases & Classifications for Paraneoplastic Syndromes

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45NINDS, 46Novoseek, 63UMLS
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Aliases & Descriptions:

paraneoplastic syndromes 45 46 63


Related Diseases for Paraneoplastic Syndromes

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Paraneoplastic Syndromes:



Diseases related to paraneoplastic syndromes

Symptoms for Paraneoplastic Syndromes

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Drugs & Therapeutics for Paraneoplastic Syndromes

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Paraneoplastic Syndromes

Drug clinical trials:

Search ClinicalTrials for Paraneoplastic Syndromes

Search NIH Clinical Center for Paraneoplastic Syndromes

Search CenterWatch for Paraneoplastic Syndromes

Genetic Tests for Paraneoplastic Syndromes

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Anatomical Context for Paraneoplastic Syndromes

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34MalaCards
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MalaCards organs/tissues related to Paraneoplastic Syndromes:

34
Lung, Breast, T cells, Ovary, Colon, Prostate, Liver, Myeloid, Testes, Brain, Thyroid, Kidney, B cells, Spinal cord

Animal Models for Paraneoplastic Syndromes or affiliated genes

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38MGI
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Publications for Paraneoplastic Syndromes

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53PubMed
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Articles related to Paraneoplastic Syndromes:

(show top 50)    (show all 355)
idTitleAuthorsYear
1
Myopathy as paraneoplastic syndrome of colon malignancy in an elderly patient. (23739910)
2013
2
Update on clinical and mechanistic aspects of paraneoplastic syndromes. (24052434)
2013
3
Lung cancer-induced paraneoplastic syndromes. (21577115)
2011
4
Paraneoplastic syndrome of inappropriate antidiuretic hormone mimicking limbic encephalitis. (22159058)
2011
5
Paraneoplastic syndromes related to lung cancer. (20529797)
2010
6
Oral cancer-associated paraneoplastic syndromes. (21180290)
2010
7
Neuromuscular paraneoplastic syndromes: the Lambert-Eaton myasthenic syndrome. (20836646)
2010
8
Review of paraneoplastic syndromes associated with oropharyngeal squamous cell carcinoma. (21731261)
2010
9
POEMS syndrome - a unique presentation of a rare paraneoplastic syndrome. (22798312)
2010
10
Paraneoplastic syndromes in patients with nasopharyngeal cancer. (19111998)
2009
11
Opsoclonus-myoclonus with multiple paraneoplastic syndromes and VGCC antibodies. (19650369)
2009
12
Marantic endocarditis as an unusual paraneoplastic syndrome of head and neck squamous cell carcinoma. (19442361)
2009
13
Acquired hypertrichosis lanuginosa: a rare cutaneous paraneoplastic syndrome. (17443005)
2007
14
Paraneoplastic syndromes affecting the nervous system. (16769417)
2006
15
Diagnosis and current treatment of neurological paraneoplastic syndromes. (17134967)
2006
16
Exacerbation of paraneoplastic syndrome of inappropriate antidiuretic hormone by parenteral nutrition in a patient affected by a large-cell neuroendocrine pancreatic cancer. (17085261)
2006
17
Parathyroid adenoma presenting as paraneoplastic syndrome secondary to renal cell carcinoma. (16048706)
2005
18
Keeping "Trk" of paraneoplastic syndromes. (16216932)
2005
19
Paraneoplastic syndromes and the nervous system. (16092599)
2005
20
Paraneoplastic syndromes associated with visual loss. (14615650)
2003
21
Some unusual paraneoplastic syndromes. Case 3. Metastatic pulmonary calcification causing hypoxemia in male breast cancer. (12829686)
2003
22
Amphiphysin paraneoplastic syndrome: a delayed diagnosis of breast carcinoma. (12846868)
2003
23
Some unusual paraneoplastic syndromes. Case 4. Paraneoplastic nephrotic syndrome in a patient with lung cancer. (12829687)
2003
24
Paraneoplastic syndromes associated with bronchogenic carcinoma. (11901915)
2002
25
New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes. (11179499)
2001
26
Paraneoplastic syndrome in the course of lung adenocarcinoma: morphological picture and immunohistochemical analysis of the inflammatory infiltrates and PECAM-1 expression. (11057031)
2000
27
Paraneoplastic syndromes of the nervous system. (10834398)
2000
28
Serum interleukin-6 levels in metastatic renal cell carcinoma before treatment with interleukin-2 correlates with paraneoplastic syndromes but not patient survival. (9474133)
1998
29
Mucocutaneous paraneoplastic syndromes (MCPS). A clinical-pathologic review. (10089068)
1998
30
Central neurological paraneoplastic syndromes. Part 1. Clinical features, pathophysiology and immunopharmacology. (15010705)
1998
31
Paraneoplastic syndromes. (9368783)
1997
32
Paraneoplastic syndromes associated with small cell lung cancer. (9001756)
1997
33
Oculomucocutaneous changes as paraneoplastic syndromes. (8803581)
1996
34
The immunobiology and clinical features of paraneoplastic syndromes. (8845924)
1995
35
Serum biological markers and paraneoplastic syndromes in Wilms tumor. (8383282)
1993
36
Mechanisms of paraneoplastic syndromes of colon-26: involvement of interleukin 6 in hypercalcemia. (8142602)
1993
37
Paraneoplastic syndromes: fads and facts (1) and neurological manifestations of malignant diseases (2) (1452572)
1992
38
Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice. (1999505)
1991
39
Neurological paraneoplastic syndromes. (3284610)
1988
40
Antineuronal autoantibodies in neurologic paraneoplastic syndromes. (3207275)
1988
41
Autoantibodies in paraneoplastic syndromes associated with small-cell lung cancer. (2842702)
1988
42
Paraneoplastic syndromes, tumor markers, and other unusual features of malignant melanoma. (2869074)
1986
43
Paraneoplastic syndromes of the nervous system. (2992171)
1985
44
Paraneoplastic syndromes: introduction. (6755479)
1982
45
Paraneoplastic syndromes in primary liver-cell carcinoma: experience in Ibadan, Nigeria. (6178279)
1980
46
Paraneoplastic syndromes of the dog. (117002)
1979
47
Paraneoplastic syndromes associated with gastrointestinal cancer. (1022379)
1976
48
Paraneoplastic syndromes in children? (1107100)
1975
49
The paraneoplastic syndromes associated with carcinoma of the thyroid gland. (4362924)
1974
50
Paraneoplastic syndromes. A clinically relevant concept in cancer. (4354413)
1973

Variations for Paraneoplastic Syndromes

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Expression for genes affiliated with Paraneoplastic Syndromes

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paraneoplastic Syndromes

Search GEO for disease gene expression data for Paraneoplastic Syndromes.

Pathways for genes affiliated with Paraneoplastic Syndromes

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Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN
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Pathways related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2CTGF, IL6
2
Show member pathways
8.8CTGF, FGF23, IL6
3
Show member pathways
8.8CTGF, FGF23, IL6
4
Show member pathways
8.8IL6, CTGF, FGF23
5
Show member pathways
8.8IL6, CTGF, FGF23
6
Show member pathways
8.8IL6, FGF23, CTGF
7
Show member pathways
8.8FGF23, CTGF, IL6
8
Show member pathways
8.8FGF23, CTGF, IL6
9
Show member pathways
8.8FGF23, CTGF, IL6
10
Show member pathways
8.8FGF23, IL6, CTGF
11
Show member pathways
8.8FGF23, IL6, CTGF
12
Show member pathways
8.8FGF23, IL6, CTGF

Compounds for genes affiliated with Paraneoplastic Syndromes

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 25HMDB, 3BitterDB, 52PharmGKB
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Compounds related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
125-hydroxyvitamin d4610.0FGF23, PTHLH
2octreotide46 62 30 1212.9FGF23, PTHLH
3hydroxyproline46 25 1211.9PTHLH, CTGF
4colchicine46 62 3 30 1213.8PTHLH, CTGF
5bleomycin46 1210.8PTHLH, CTGF
6nocodazole46 1210.7CTGF, PTHLH
7lovastatin46 52 62 30 1213.7CTGF, PTHLH
8hydroxyapatite469.5PTHLH, CTGF, FGF23
915-deoxy-delta-12,14-prostaglandin j2469.5CTGF, IL6
10pamidronate46 52 1211.5IL6, PTHLH
11clodronate46 52 1211.5IL6, PTHLH
12zoledronic acid469.5IL6, PTHLH
13pioglitazone30 46 52 1212.5CTGF, IL6
14heparin46 30 25 1212.5PTHLH, CTGF, FGF23
15pravastatin46 52 30 25 1213.5IL6, CTGF
16aprotinin46 1210.4IL6, PTHLH
17sp 60012546 6210.4IL6, CTGF
18phosphorus469.4PTHLH, PHEX, FGF23
191,25 dihydroxy vitamin d3469.4PTHLH, PHEX, FGF23
20prednisolone46 30 1211.3IL6, PTHLH
21hydrocortisone46 3 62 1212.2PTHLH, IL6
22nifedipine46 30 52 1212.2CTGF, PTHLH
23rosiglitazone30 46 52 25 1213.1IL6, PTHLH
24tgf beta1469.1CTGF, IL6, PTHLH
25simvastatin46 52 62 30 25 1214.1PTHLH, IL6, CTGF
26prostaglandin469.1PTHLH, IL6, CTGF
27sb 20358046 6210.1AIRE, IL6, CTGF
28pge2469.0PTHLH, IL6, CTGF
29lactate469.0CTGF, IL6, PTHLH
30troglitazone46 30 62 1212.0PTHLH, IL6
31thymidine46 2510.0CTGF, IL6, PTHLH
32cycloheximide469.0PTHLH, IL6, CTGF
33serine468.9FGF23, CTGF, PTHLH, AIRE
34dexamethasone46 52 30 1211.9CTGF, IL6, PTHLH
35vegf468.7CTGF, IL6, PTHLH
36creatinine468.7FGF23, CTGF, IL6, PTHLH
37nitric oxide46 25 1210.7CTGF, IL6, PTHLH
38calcitriol46 62 25 1211.6FGF23, PHEX, IL6, PTHLH
39vitamin d468.6FGF23, PHEX, IL6, PTHLH
40tyrosine468.2FGF23, CTGF, IL6, PTHLH, AIRE

GO Terms for genes affiliated with Paraneoplastic Syndromes

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17Gene Ontology
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Cellular components related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:0057948.9CTGF, PHEX, PTHLH
2extracellular spaceGO:0056158.2FGF23, CTGF, IL6, PTHLH
3extracellular regionGO:0055768.0PTHLH, IL6, CTGF, FGF23

Biological processes related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hormone secretionGO:0468889.4FGF23, IL6
2skeletal system developmentGO:0015019.3PHEX, PTHLH
3response to amino acidGO:0432009.3CTGF, IL6
4epidermis developmentGO:0085449.2CTGF, PTHLH
5humoral immune responseGO:0069599.1IL6, AIRE
6positive regulation of ERK1 and ERK2 cascadeGO:0703749.0FGF23, CTGF, IL6
7positive regulation of cell proliferationGO:0082848.7PTHLH, IL6, CTGF
8positive regulation of transcription, DNA-templatedGO:0458938.7AIRE, IL6, FGF23

Molecular functions related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080838.8FGF23, CTGF, IL6

Products for genes affiliated with Paraneoplastic Syndromes

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Sources for Paraneoplastic Syndromes

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet