MCID: PRN039
MIFTS: 47

Paraneoplastic Syndromes malady

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Summaries for Paraneoplastic Syndromes

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NINDS:43 Paraneoplastic syndromes are a group of rare disorders that are triggered by an abnormal immune system response to a cancerous tumor known as a "neoplasm." Paraneoplastic syndromes are thought to happen when cancer-fighting antibodies or white blood cells (known as T cells) mistakenly attack normal cells in the nervous system. These disorders typically affect middle-aged to older people and are most common in individuals with lung, ovarian, lymphatic, or breast cancer. Neurologic symptoms generally develop over a period of days to weeks and usually occur prior to the tumor being discovered. These symptoms may include difficulty in walking or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo or dizziness. Paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis, myasthenia gravis, cerebellar degeneration, limbic or brainstem encephalitis, neuromyotonia, opsoclonus, and sensory neuropathy.

MalaCards based summary: Paraneoplastic Syndromes is related to hypercalcemia and osteomalacia. An important gene associated with Paraneoplastic Syndromes is FGF23 (fibroblast growth factor 23), and among its related pathways are amb2 Integrin signaling and PAK Pathway. The compounds 25-hydroxyvitamin d and octreotide have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and t cells, and related mouse phenotypes are limbs/digits/tail and reproductive system.

Wikipedia:65 A paraneoplastic syndrome is a disease or symptom that is the consequence of cancer in the body but,... more...

Aliases & Classifications for Paraneoplastic Syndromes

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Sources:
43NINDS, 44Novoseek, 62UMLS
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Paraneoplastic Syndromes, Aliases & Descriptions:

Name: Paraneoplastic Syndromes 43 44 62


Related Diseases for Paraneoplastic Syndromes

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Diseases related to Paraneoplastic Syndromes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 196)
idRelated DiseaseScoreTop Affiliating Genes
1hypercalcemia30.8PTHLH, FGF23
2osteomalacia30.3PTHLH, FGF23, PHEX
3peritonitis30.1IL6, CTGF
4lung cancer10.6
5mccune albright syndrome10.5FGF23
6renal cell carcinoma10.4
7hepatocellular carcinoma10.3
8lambert-eaton myasthenic syndrome10.3
9breast cancer10.3
10adenocarcinoma10.3
11thymoma10.3
12lung adenocarcinoma10.3
13ovarian cancer10.3
14cerebellar degeneration10.3
15neuroendocrine carcinoma10.2
16neuronitis10.2
17prostatitis10.2
18oral cancer10.2
19syndrome of inappropriate antidiuretic hormone10.2
20pyridoxine-refractory autosomal recessive sideroblastic anemia10.2FGF23, AIRE
21primary hyperparathyroidism10.2FGF23, PTHLH
22secondary hyperparathyroidism of renal origin10.2FGF23, PTHLH
23hypophosphatemic rickets, autosomal dominant10.2FGF23, PHEX
24synovitis10.2IL6
25x-linked hypophosphatemia10.2FGF23, PHEX
26leukemia10.2
27myasthenia gravis10.2
28non-small cell lung carcinoma10.2
29prostate cancer10.2
30thrombocytosis10.2
31adult-onset still's disease10.2
32paraneoplastic polyneuropathy10.2
33acanthosis nigricans10.2
34dermatomyositis10.2
35fasciitis10.2
36ganglioneuroblastoma10.2
37laryngitis10.2
38melanoma10.2
39pancreatitis10.2
40sarcoma10.2
41thyroiditis10.2
42pheochromocytoma10.2
43oncogenic osteomalacia10.2
44polymyositis10.2
45subacute cerebellar degeneration10.2
46metaphyseal dysplasia10.2AIRE, PTHLH
47rickets10.2PHEX, FGF23
48infertility10.1DAZL, FGF23
49b-cell lymphomas10.1
50hodgkin's lymphoma10.1

Graphical network of the top 20 diseases related to Paraneoplastic Syndromes:



Diseases related to paraneoplastic syndromes

Symptoms for Paraneoplastic Syndromes

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Drugs & Therapeutics for Paraneoplastic Syndromes

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Drug clinical trials:

Search ClinicalTrials for Paraneoplastic Syndromes

Search NIH Clinical Center for Paraneoplastic Syndromes

Genetic Tests for Paraneoplastic Syndromes

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Anatomical Context for Paraneoplastic Syndromes

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MalaCards organs/tissues related to Paraneoplastic Syndromes:

32
Lung, Breast, T cells, Ovary, Colon, Prostate, Liver, Thyroid, Brain, Kidney, Testes, B cells, Spinal cord, Myeloid

Animal Models for Paraneoplastic Syndromes or affiliated genes

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Publications for Paraneoplastic Syndromes

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Articles related to Paraneoplastic Syndromes:

(show top 50)    (show all 366)
idTitleAuthorsYear
1
Myopathy as paraneoplastic syndrome of colon malignancy in an elderly patient. (23739910)
2013
2
Update on clinical and mechanistic aspects of paraneoplastic syndromes. (24052434)
2013
3
Lung cancer-induced paraneoplastic syndromes. (21577115)
2011
4
Unusual paraneoplastic syndromes of breast carcinoma: a combination of cerebellar degeneration and Lambert-Eaton Myasthenic Syndrome. (19005633)
2011
5
Paraneoplastic syndrome of inappropriate antidiuretic hormone mimicking limbic encephalitis. (22159058)
2011
6
Paraneoplastic syndromes related to lung cancer. (20529797)
2010
7
Oral cancer-associated paraneoplastic syndromes. (21180290)
2010
8
Neuromuscular paraneoplastic syndromes: the Lambert-Eaton myasthenic syndrome. (20836646)
2010
9
Review of paraneoplastic syndromes associated with oropharyngeal squamous cell carcinoma. (21731261)
2010
10
POEMS syndrome - a unique presentation of a rare paraneoplastic syndrome. (22798312)
2010
11
Paraneoplastic syndromes in patients with nasopharyngeal cancer. (19111998)
2009
12
Opsoclonus-myoclonus with multiple paraneoplastic syndromes and VGCC antibodies. (19650369)
2009
13
Marantic endocarditis as an unusual paraneoplastic syndrome of head and neck squamous cell carcinoma. (19442361)
2009
14
Acquired hypertrichosis lanuginosa: a rare cutaneous paraneoplastic syndrome. (17443005)
2007
15
Paraneoplastic syndromes affecting the nervous system. (16769417)
2006
16
Diagnosis and current treatment of neurological paraneoplastic syndromes. (17134967)
2006
17
Exacerbation of paraneoplastic syndrome of inappropriate antidiuretic hormone by parenteral nutrition in a patient affected by a large-cell neuroendocrine pancreatic cancer. (17085261)
2006
18
Parathyroid adenoma presenting as paraneoplastic syndrome secondary to renal cell carcinoma. (16048706)
2005
19
Keeping "Trk" of paraneoplastic syndromes. (16216932)
2005
20
Paraneoplastic syndromes and the nervous system. (16092599)
2005
21
Paraneoplastic syndromes associated with visual loss. (14615650)
2003
22
Some unusual paraneoplastic syndromes. Case 3. Metastatic pulmonary calcification causing hypoxemia in male breast cancer. (12829686)
2003
23
Amphiphysin paraneoplastic syndrome: a delayed diagnosis of breast carcinoma. (12846868)
2003
24
Some unusual paraneoplastic syndromes. Case 4. Paraneoplastic nephrotic syndrome in a patient with lung cancer. (12829687)
2003
25
Paraneoplastic syndromes associated with bronchogenic carcinoma. (11901915)
2002
26
New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes. (11179499)
2001
27
Paraneoplastic syndrome in the course of lung adenocarcinoma: morphological picture and immunohistochemical analysis of the inflammatory infiltrates and PECAM-1 expression. (11057031)
2000
28
Paraneoplastic syndromes of the nervous system. (10834398)
2000
29
Serum interleukin-6 levels in metastatic renal cell carcinoma before treatment with interleukin-2 correlates with paraneoplastic syndromes but not patient survival. (9474133)
1998
30
Mucocutaneous paraneoplastic syndromes (MCPS). A clinical-pathologic review. (10089068)
1998
31
Central neurological paraneoplastic syndromes. Part 1. Clinical features, pathophysiology and immunopharmacology. (15010705)
1998
32
Paraneoplastic syndromes. (9368783)
1997
33
Paraneoplastic syndromes associated with small cell lung cancer. (9001756)
1997
34
Oculomucocutaneous changes as paraneoplastic syndromes. (8803581)
1996
35
Serum biological markers and paraneoplastic syndromes in Wilms tumor. (8383282)
1993
36
Mechanisms of paraneoplastic syndromes of colon-26: involvement of interleukin 6 in hypercalcemia. (8142602)
1993
37
Paraneoplastic syndromes: fads and facts (1) and neurological manifestations of malignant diseases (2) (1452572)
1992
38
Paraneoplastic syndromes. (1620362)
1992
39
Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice. (1999505)
1991
40
Neurological paraneoplastic syndromes. (3284610)
1988
41
Antineuronal autoantibodies in neurologic paraneoplastic syndromes. (3207275)
1988
42
Autoantibodies in paraneoplastic syndromes associated with small-cell lung cancer. (2842702)
1988
43
Paraneoplastic syndromes, tumor markers, and other unusual features of malignant melanoma. (2869074)
1986
44
Paraneoplastic syndromes of the nervous system. (2992171)
1985
45
Paraneoplastic syndromes: introduction. (6755479)
1982
46
Paraneoplastic syndromes of the dog. (117002)
1979
47
Paraneoplastic syndromes associated with gastrointestinal cancer. (1022379)
1976
48
Paraneoplastic syndromes in children? (1107100)
1975
49
The paraneoplastic syndromes associated with carcinoma of the thyroid gland. (4362924)
1974
50
Paraneoplastic syndromes. A clinically relevant concept in cancer. (4354413)
1973

Variations for Paraneoplastic Syndromes

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Expression for genes affiliated with Paraneoplastic Syndromes

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Expression patterns in normal tissues for genes affiliated with Paraneoplastic Syndromes

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Pathways for genes affiliated with Paraneoplastic Syndromes

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Pathways related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2CTGF, IL6
2
Show member pathways
8.8CTGF, FGF23, IL6
3
Show member pathways
8.8CTGF, FGF23, IL6
4
Show member pathways
8.8IL6, CTGF, FGF23
5
Show member pathways
8.8IL6, CTGF, FGF23
6
Show member pathways
8.8IL6, FGF23, CTGF
7
Show member pathways
8.8FGF23, CTGF, IL6
8
Show member pathways
8.8FGF23, CTGF, IL6
9
Show member pathways
8.8FGF23, CTGF, IL6
10
Show member pathways
8.8FGF23, IL6, CTGF
11
Show member pathways
8.8FGF23, IL6, CTGF
12
Show member pathways
8.8FGF23, IL6, CTGF

Compounds for genes affiliated with Paraneoplastic Syndromes

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Compounds related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
125-hydroxyvitamin d4410.0FGF23, PTHLH
2octreotide44 61 28 1112.9PTHLH, FGF23
3hydroxyproline44 24 1111.9PTHLH, CTGF
4colchicine44 61 2 28 1113.8CTGF, PTHLH
5bleomycin44 1110.8PTHLH, CTGF
6nocodazole44 1110.7PTHLH, CTGF
7lovastatin44 50 61 28 1113.7PTHLH, CTGF
8hydroxyapatite449.5CTGF, FGF23, PTHLH
915-deoxy-delta-12,14-prostaglandin j2449.5IL6, CTGF
10pamidronate44 50 1111.5IL6, PTHLH
11clodronate44 50 1111.5PTHLH, IL6
12zoledronic acid449.5IL6, PTHLH
13pioglitazone28 44 50 1112.5IL6, CTGF
14heparin44 28 24 1112.5FGF23, CTGF, PTHLH
15pravastatin44 50 28 24 1113.5CTGF, IL6
16aprotinin44 1110.4PTHLH, IL6
17sp 60012544 6110.4CTGF, IL6
18phosphorus449.4FGF23, PHEX, PTHLH
191,25 dihydroxy vitamin d3449.4PHEX, FGF23, PTHLH
20prednisolone44 28 1111.3IL6, PTHLH
21hydrocortisone44 2 61 1112.2PTHLH, IL6
22nifedipine44 28 50 1112.2CTGF, PTHLH
23rosiglitazone28 44 50 24 1113.1PTHLH, IL6
24tgf beta1449.1IL6, PTHLH, CTGF
25simvastatin44 50 61 28 24 1114.1IL6, CTGF, PTHLH
26prostaglandin449.1CTGF, PTHLH, IL6
27sb 20358044 6110.1IL6, AIRE, CTGF
28pge2449.0PTHLH, IL6, CTGF
29lactate449.0PTHLH, IL6, CTGF
30troglitazone44 28 61 1112.0IL6, PTHLH
31thymidine44 2410.0IL6, PTHLH, CTGF
32cycloheximide449.0CTGF, IL6, PTHLH
33serine448.9AIRE, CTGF, FGF23, PTHLH
34dexamethasone44 50 28 1111.9IL6, PTHLH, CTGF
35vegf448.7PTHLH, CTGF, IL6
36creatinine448.7FGF23, CTGF, PTHLH, IL6
37nitric oxide44 24 1110.7IL6, CTGF, PTHLH
38calcitriol44 61 24 1111.6PHEX, PTHLH, FGF23, IL6
39vitamin d448.6PTHLH, PHEX, IL6, FGF23
40tyrosine448.2PTHLH, AIRE, FGF23, CTGF, IL6

GO Terms for genes affiliated with Paraneoplastic Syndromes

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Cellular components related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:0057948.9CTGF, PHEX, PTHLH
2extracellular spaceGO:0056158.2CTGF, PTHLH, IL6, FGF23
3extracellular regionGO:0055768.0FGF23, PTHLH, IL6, CTGF

Biological processes related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hormone secretionGO:0468889.4IL6, FGF23
2skeletal system developmentGO:0015019.3PTHLH, PHEX
3response to amino acidGO:0432009.3IL6, CTGF
4epidermis developmentGO:0085449.2CTGF, PTHLH
5humoral immune responseGO:0069599.1IL6, AIRE
6positive regulation of ERK1 and ERK2 cascadeGO:0703749.0IL6, CTGF, FGF23
7positive regulation of cell proliferationGO:0082848.7PTHLH, IL6, CTGF
8positive regulation of transcription, DNA-templatedGO:0458938.7AIRE, FGF23, IL6

Molecular functions related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080838.8FGF23, CTGF, IL6

Products for genes affiliated with Paraneoplastic Syndromes

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Sources for Paraneoplastic Syndromes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet