Aliases & Classifications for Paraneoplastic Syndromes

Aliases & Descriptions for Paraneoplastic Syndromes:

Name: Paraneoplastic Syndromes 51 52 69

Summaries for Paraneoplastic Syndromes

NINDS : 51 Paraneoplastic syndromes are a group of rare disorders that are triggered by an abnormal immune system response to a cancerous tumor known as a "neoplasm." Paraneoplastic syndromes are thought to happen when cancer-fighting antibodies or white blood cells (known as T cells) mistakenly attack normal cells in the nervous system. These disorders typically affect middle-aged to older people and are most common in individuals with lung, ovarian, lymphatic, or breast cancer. Neurologic symptoms generally develop over a period of days to weeks and usually occur prior to the tumor being discovered. These symptoms may include difficulty in walking or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo or dizziness. Paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis, myasthenia gravis, cerebellar degeneration, limbic or brainstem encephalitis, neuromyotonia, opsoclonus, and sensory neuropathy.

MalaCards based summary : Paraneoplastic Syndromes is related to intrahepatic cholestasis and paraneoplastic cerebellar degeneration, and has symptoms including paraneoplastic opsoclonus ataxia An important gene associated with Paraneoplastic Syndromes is FGF23 (Fibroblast Growth Factor 23). The drugs Mitoxantrone and Lansoprazole have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and t cells.

Wikipedia : 71 A paraneoplastic syndrome is a syndrome (a set of signs and symptoms) that is the consequence of cancer... more...

Related Diseases for Paraneoplastic Syndromes

Diseases related to Paraneoplastic Syndromes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
id Related Disease Score Top Affiliating Genes
1 intrahepatic cholestasis 29.1 IL6 PTHLH
2 paraneoplastic cerebellar degeneration 11.3
3 lambert-eaton myasthenic syndrome 11.1
4 autoimmune encephalitis 11.1
5 adenoma 11.1
6 leiomyoma 10.7
7 carcinoid syndrome 10.7
8 multicentric reticulohistiocytosis 10.7
9 lung cancer 10.1
10 neutrophilia, hereditary 10.1 IL6 PTHLH
11 opthalmoplegia mental retardation lingua scrotalis 10.0 FGF23 PTHLH
12 maroteaux stanescu cousin syndrome 10.0 FGF23 PTHLH
13 toenail dystrophy, isolated 10.0 FGF23 PTHLH
14 opioid abuse 10.0 FGF23 PTHLH
15 pre-eclampsia 10.0 FGF23 PTHLH
16 indian tick typhus 10.0 FGF23 PTHLH
17 body dysmorphic disorder 10.0 IL6 PTHLH
18 parathyroid carcinoma 10.0 FGF23 PTHLH
19 parathyroid gland disease 10.0 FGF23 PTHLH
20 subserous uterine fibroid 9.9 FGF23 PTHLH
21 calcinosis 9.9 FGF23 IL6
22 lymphoma 9.9
23 renal cell carcinoma 9.9
24 squamous cell carcinoma 9.9
25 breast cancer 9.8
26 chronic myocardial ischemia 9.8 FGF23 IL6
27 carnitine deficiency, systemic primary 9.8 FGF23 IL6 PTHLH
28 hepatocellular carcinoma 9.8
29 thymoma 9.8
30 cerebellar degeneration 9.8
31 adenocarcinoma 9.8
32 leukemia 9.7
33 ovarian cancer 9.7
34 osteomalacia 9.7
35 acanthosis nigricans 9.7
36 ganglioneuroblastoma 9.7
37 oral cancer 9.7
38 encephalitis 9.7
39 polymyositis 9.7
40 laryngitis 9.7
41 neuronitis 9.7
42 adult-onset still's disease 9.7
43 syndrome of inappropriate antidiuretic hormone 9.7
44 small cell carcinoma 9.7
45 prostatitis 9.7
46 neuroblastoma 9.7
47 prostate cancer 9.6
48 limbic encephalitis 9.6
49 oncogenic osteomalacia 9.6
50 melanoma 9.6

Graphical network of the top 20 diseases related to Paraneoplastic Syndromes:



Diseases related to Paraneoplastic Syndromes

Symptoms & Phenotypes for Paraneoplastic Syndromes

UMLS symptoms related to Paraneoplastic Syndromes:


paraneoplastic opsoclonus ataxia

Drugs & Therapeutics for Paraneoplastic Syndromes

Drugs for Paraneoplastic Syndromes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 121)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
2
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
3
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
4 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
5 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
6
Dexlansoprazole Phase 4 138530-94-6, 103577-45-3 9578005
7
Proton pump inhibitors Phase 4,Phase 3,Phase 2
8 interferons Phase 4,Phase 2
9 Analgesics Phase 4
10 Adjuvants, Immunologic Phase 4
11 Topoisomerase Inhibitors Phase 4,Phase 2
12 Antacids Phase 4,Phase 3,Phase 2
13 Anti-Infective Agents Phase 4,Phase 2
14 Interferon-beta Phase 4
15 Anti-Ulcer Agents Phase 4,Phase 3,Phase 2
16 Antiviral Agents Phase 4,Phase 2
17
rituximab Approved Phase 3,Phase 2,Phase 1 174722-31-7 10201696
18
4-Aminopyridine Approved Phase 3,Phase 2 504-24-5 1727
19
Zoledronic acid Approved Phase 3,Phase 1,Phase 2 118072-93-8 68740
20
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
21
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
22
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
23
Esomeprazole Approved, Investigational Phase 3 161796-78-7, 119141-88-7 4594 9579578
24
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
25 Prednisolone acetate Phase 3
26 Ibandronic acid Phase 3
27 glucocorticoids Phase 3,Phase 1
28 Neuroprotective Agents Phase 3
29 Hormone Antagonists Phase 3,Phase 2,Phase 1,Early Phase 1
30 Diphosphonates Phase 3,Phase 1,Phase 2
31 Hormones Phase 3,Phase 2,Phase 1,Early Phase 1
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1,Early Phase 1
33 Potassium Channel Blockers Phase 3,Phase 2
34 Prednisolone hemisuccinate Phase 3
35 3,4-diaminopyridine Phase 3,Phase 2
36 Prednisolone phosphate Phase 3
37 Protective Agents Phase 3
38 Antiemetics Phase 3
39 Anti-Inflammatory Agents Phase 3
40 Methylprednisolone acetate Phase 3
41 Methylprednisolone Hemisuccinate Phase 3
42 Antirheumatic Agents Phase 3,Phase 2,Phase 1
43 Autonomic Agents Phase 3,Phase 1,Phase 2
44 Bone Density Conservation Agents Phase 3,Phase 1,Phase 2
45 Immunoglobulins Phase 3,Phase 1,Phase 2
46 Immunosuppressive Agents Phase 3,Phase 2
47 Antibodies Phase 3,Phase 1,Phase 2
48 Antineoplastic Agents, Hormonal Phase 3,Phase 2
49 Dexamethasone acetate Phase 3 1177-87-3
50 Alkylating Agents Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 74)
id Name Status NCT ID Phase
1 Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis Completed NCT00179478 Phase 4
2 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease) Completed NCT00304291 Phase 4
3 Treatment of Zollinger-Ellison Syndrome With Prevacid Completed NCT00204373 Phase 4
4 Ibandronate or Zoledronate in Treating Patients With Newly Diagnosed Bone Metastases From Breast Cancer Unknown status NCT00326820 Phase 3
5 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
6 Zoledronate in Treating Patients With Solid Tumors That Have Spread to the Bone Completed NCT00003884 Phase 3
7 A Phase 3 Study of Amifampridine Phosphate in Patients With Lambert Eaton Myasthenic Syndrome (LEMS) Completed NCT01377922 Phase 3
8 Esomeprazole In Patients With Gastric Acid Hypersecretory States Including Idiopathic Hypersecretion and Zollinger-Ellison Syndrome Completed NCT00079833 Phase 3
9 A Phase I/III Study of D961H 10 mg and 20 mg in Japanese Paediatric Patients With Gastrointestinal Acid Related Diseases Completed NCT02153398 Phase 3
10 Phase 3 Study to Evaluate Efficacy of Amifampridine Phosphate in Lambert-Eaton Myasthenic Syndrome (LEMS) Recruiting NCT02970162 Phase 3
11 Amifampridine Phosphate for the Treatment of Congenital Myasthenic Syndromes Recruiting NCT02562066 Phase 3
12 Opsoclonus Myoclonus Syndrome/Dancing Eye Syndrome (OMS/DES) in Children With and Without Neuroblastoma (NBpos and NBneg)Opsoclonus Myoclonus Syndrome/Dancing Eye Syndrome (OMS/DES) in Children With and Without Neuroblastoma (NBpos and NBneg) Recruiting NCT01868269 Phase 3
13 Use of 3,4-Diaminopyridine in the Treatment of Lambert-Eaton Syndrome Available NCT01825395 Phase 3
14 A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin Versus Standard Therapy for Transverse Myelitis Terminated NCT02398994 Phase 3
15 S0308 Zoledronate or Ibandronate in Preventing Bone Problems in Women With Stage IV Breast Cancer That Has Spread to the Bone Withdrawn NCT00301886 Phase 3
16 Effectiveness of 3,4-Diaminopyridine in Lambert-Eaton Myasthenic Syndrome Unknown status NCT01511978 Phase 2
17 Ephedrine for the Treatment of Congenital Myasthenia Unknown status NCT00541216 Phase 1, Phase 2
18 Use of Rituximab in Opsoclonus-Myoclonus in Children With Neuroblastoma Unknown status NCT00202930 Phase 2
19 Monoclonal Antibody Compared With Zoledronate in Treating Women With Breast Cancer and Bone Metastases Completed NCT00060138 Phase 1, Phase 2
20 MC-5A for Chemotherapy Induced Peripheral Neuropathy Completed NCT01261780 Phase 2
21 Effectiveness of Rituximab in Pediatric OMS Patients. Completed NCT00244361 Phase 1, Phase 2
22 Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium Completed NCT00896454 Phase 2
23 The Use of Oral Omeprazole and Intravenous Pantoprazole in Patients With Hypersecretion of Gastric Acid Completed NCT00001191 Phase 2
24 Interferon and Octreotide to Treat Zollinger-Ellison Syndrome and Advanced Non-B Islet Cell Cancer Completed NCT00001228 Phase 2
25 Combination Chemotherapy in Patients With Zollinger-Ellison Syndrome and Tumors of the Pancreas Completed NCT00001165 Phase 2
26 Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome Recruiting NCT02468193 Phase 2
27 SOM230 Ectopic ACTH-producing Tumors Recruiting NCT02780882 Phase 2
28 Immunotherapy and Paraneoplastic Neurological Syndromes Active, not recruiting NCT02343211 Phase 2
29 Safety and Efficacy of Sustained Release Dalfampridine in Transverse Myelitis (Re-Launch) Active, not recruiting NCT02166346 Phase 2
30 YF476 and Type II Gastric Carcinoids Enrolling by invitation NCT02454075 Phase 2
31 IVIG Treatment for Refractory Immune-Related Adult Epilepsy Terminated NCT01545518 Phase 2
32 Study of Pasireotide in Patients With Rare Tumors of Neuroendocrine Origin Terminated NCT00958841 Phase 2
33 Efficacy of Albuterol in the Treatment of Congenital Myasthenic Syndromes Completed NCT01203592 Phase 1
34 Safety and Tolerability of Rituximab in Neuromyelitis Optica Completed NCT00501748 Phase 1
35 Central Pain Study for ABX-1431 Recruiting NCT03138421 Phase 1
36 Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses Active, not recruiting NCT02276963 Phase 1
37 Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor Not yet recruiting NCT02831179 Phase 1
38 One Week Comparison Study of PTH and PTHrP Infusions Withdrawn NCT01333267 Phase 1
39 Comparison of Two Schedules of Zoledronic Acid in Treating Patients With Breast Cancer That Has Spread to the Bone Unknown status NCT00458796
40 Multicenter and Prospective Clinical Registry Study of Anti-N-methyl-D-aspartate Receptor Encephalitis in Beijing Area Unknown status NCT02443350
41 A Longitudinal Study of Neuromyelitis Optica and Transverse Myelitis Unknown status NCT01623076
42 Immunotherapy of the Paraneoplastic Syndromes Completed NCT00378326
43 Studies of Neurological Paraneoplastic Syndromes Completed NCT00587106
44 Study of Cytokines in Children With Opsoclonus-Myoclonus Syndrome Completed NCT00806182
45 One Week Parathyroid Hormone-related Protein (PTHrP) IV Dose Escalation Study Completed NCT00580788 Early Phase 1
46 Pregnancy Outcomes in Congenital Myasthenie Syndrome Completed NCT01474980
47 Randomized Study of 3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome Completed NCT00004832
48 Transcranial Direct Current Stimulation on Cortical Plasticity in Patients With Anti-NMDA Receptor Encephalitis Completed NCT01865578
49 Treatment of Zollinger-Ellison Syndrome Completed NCT00001241
50 Evaluating Pancreatic Tumors in Patients With Zollinger-Ellison Syndrome Completed NCT00001254

Search NIH Clinical Center for Paraneoplastic Syndromes

Genetic Tests for Paraneoplastic Syndromes

Anatomical Context for Paraneoplastic Syndromes

MalaCards organs/tissues related to Paraneoplastic Syndromes:

39
Lung, Breast, T Cells, Colon, Prostate, Myeloid, Thyroid

Publications for Paraneoplastic Syndromes

Articles related to Paraneoplastic Syndromes:

(show top 50) (show all 413)
id Title Authors Year
1
Alopecia areata as a paraneoplastic syndrome of gastric cancer. ( 27990839 )
2017
2
Intermittent Fever, Progressive Weight Gain, and Personality Changes in a Five-Year-Old Girl: Unusual Paraneoplastic Syndrome due to Presacral Ganglioneuroma. ( 27413558 )
2016
3
Paraneoplastic syndromes are associated with adverse prognosis among patients with renal cell carcinoma undergoing nephrectomy. ( 26914818 )
2016
4
Paraneoplastic syndromes (PNS) associated with Merkel cell carcinoma (MCC): A case series of 8 patients highlighting different clinical manifestations. ( 27177440 )
2016
5
Aggressive cervical neuroblastoma with a rare paraneoplastic syndrome: A therapeutic dilemma. ( 27695211 )
2016
6
Severe Hyponatremia Presenting as Paraneoplastic Syndrome in a Patient with Small Cell Carcinoma of Gallbladder. ( 27225161 )
2016
7
Comments on Kristensen et al.: Clinical value of FDG-PET/CT in suspected paraneoplastic syndromes: a retrospective analysis of 137 patients. ( 26666237 )
2016
8
Laryngeal carcinoma presenting as polymyositis: A paraneoplastic syndrome. ( 27011653 )
2016
9
Caution is Needed in Diagnosing IgG4-Related Disease: A Possible Paraneoplastic Syndrome. ( 27863169 )
2016
10
Intrathecal synthesis of onconeural antibodies in patients with paraneoplastic syndromes. ( 26711581 )
2016
11
Paraneoplastic Syndrome in Splenic Marginal Zone Lymphoma: A Rare Phenomenon of Paraplegia as an Atypical Presenting Manifestation. ( 27293921 )
2016
12
Autoantibody diversity in paraneoplastic syndromes and related disorders: The need for a more guided screening approach. ( 27287529 )
2016
13
Papilledema secondary to a superior sagittal sinus thrombosis. Mantle cell lymphoma paraneoplastic syndrome. ( 26596713 )
2016
14
A case of acanthosis nigricans as a paraneoplastic syndrome with squamous cell lung cancer. ( 27536145 )
2016
15
Tumour-induced osteomalacia: An emergent paraneoplastic syndrome. ( 26718193 )
2016
16
The lung cancer nurse role in the management of paraneoplastic syndromes in lung cancer. ( 27413699 )
2016
17
Reply to: "Comments on Kristensen et al.: Clinical value of FDG-PET/CT in suspected paraneoplastic syndromes: a retrospective analysis of 137 patients": By BetA1l Vatankulu, Sabire Yilmaz Aksoy, Sait Sager, Metin HalaAs. ( 26669307 )
2016
18
Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS syndrome): a paraneoplastic syndrome. ( 26634133 )
2015
19
Paraneoplastic syndromes in olfactory neuroblastoma. ( 26199564 )
2015
20
Paraneoplastic syndrome: a masquerade of autoimmune inner ear disease. ( 25427223 )
2015
21
Cerebellar Degeneration as a Rare Paraneoplastic Syndrome in a Child With Hodgkin Lymphoma. ( 26599987 )
2015
22
Paraneoplastic Syndrome of Angiomatoid Fibrous Histiocytoma May Be Caused by EWSR1-CREB1 Fusion-induced Excessive Interleukin-6 Production. ( 26165403 )
2015
23
Eosinophilic esophagitis as paraneoplastic syndrome in a patient with ganglioneuroblastoma. ( 25985452 )
2015
24
Possible paraneoplastic syndrome case of bullous pemphigoid with immunoglobulin G anti-BP180 C-terminal domain antibodies associated with psoriasis and primary macroglobulinemia. ( 26507447 )
2015
25
A rare thymoma case with seven paraneoplastic syndromes. ( 26770603 )
2015
26
Bicytopenia as a paraneoplastic syndrome for pseudomyxoma peritonei. Hematologic manifestations of a subtle disease. ( 25767403 )
2015
27
Resolution of hypercalcemia of malignancy following radical cystectomy in a patient with paraneoplastic syndrome associated with urothelial carcinoma of the bladder. ( 25657552 )
2015
28
Different Kinds of Paraneoplastic Syndromes in Childhood Neuroblastoma. ( 26199695 )
2015
29
Leukemoid reaction as a paraneoplastic syndrome in hypopharyngeal squamous cell carcinoma with cutaneous metastasis: an exceedingly rare occurrence. ( 26670890 )
2015
30
Update on neurological paraneoplastic syndromes. ( 26335665 )
2015
31
Membranous glomerulonephritis as a novel paraneoplastic syndrome in a young man with chronic myeloid leukemia. ( 26062944 )
2015
32
Piriform sinus carcinoma with a paraneoplastic syndrome misdiagnosed as adult onset Still's disease: a case report. ( 26770614 )
2015
33
Clinical value of FDG-PET/CT in suspected paraneoplastic syndromes: a retrospective analysis of 137 patients. ( 26194717 )
2015
34
Paraneoplastic Syndromes in Palliative Care: A literature review from a nursing perspective. ( 26514024 )
2015
35
Paraneoplastic syndromes: the way to an early diagnosis of lung cancer. ( 26506668 )
2015
36
Paraneoplastic Syndromes in Neuro-Ophthalmology. ( 26172160 )
2015
37
Paraneoplastic cerebellar ataxia and the paraneoplastic syndromes. ( 25829659 )
2015
38
A rare case of severe myositis as paraneoplastic syndrome on breast cancer. ( 25890160 )
2015
39
Hyperamylasaemia and dual paraneoplastic syndromes in small cell lung cancer. ( 24048720 )
2014
40
Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance. ( 25351497 )
2014
41
Paraneoplastic limbic encephalitis--neurologic paraneoplastic syndrome associated with ovarian malignancy--the importance of clinical recognition. ( 25507435 )
2014
42
Leukemoid reaction: a rare paraneoplastic syndrome in bladder cancer associated with a grave prognosis. ( 24044914 )
2014
43
Lung squamous carcinoma with two paraneoplastic syndromes -Dermatomyositis and Lambert-Eaton myasthenic syndrome. ( 25335449 )
2014
44
Ectopic Cushing syndrome secondary to metastatic medullary thyroid cancer in a child with multiple endocrine neoplasia syndrome type 2B: clues to early diagnosis of the paraneoplastic syndromes. ( 24859505 )
2014
45
RNA polymerase III autoantibody scleroderma as a paraneoplastic syndrome: Comment on the article by Stojan et al. ( 25303107 )
2014
46
Prognostic role and significance of paraneoplastic syndromes in hepatocellular carcinoma. ( 24480222 )
2014
47
Multiple paraneoplastic syndromes revealing non-small cell lung carcinoma. ( 25838865 )
2014
48
Paraneoplastic limbic encephalitis--neurologic paraneoplastic syndrome associated with ovarian malignancy--the importance of clinical recognition. ( 25423712 )
2014
49
Paraneoplastic syndromes in rheumatology. ( 25136782 )
2014
50
Eosinophilic fasciitis as a paraneoplastic syndrome, a case report and review of the literature. ( 24525268 )
2014

Variations for Paraneoplastic Syndromes

Expression for Paraneoplastic Syndromes

Search GEO for disease gene expression data for Paraneoplastic Syndromes.

Pathways for Paraneoplastic Syndromes

GO Terms for Paraneoplastic Syndromes

Biological processes related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 8.96 FGF23 IL6
2 negative regulation of hormone secretion GO:0046888 8.62 FGF23 IL6

Molecular functions related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.62 FGF23 IL6

Sources for Paraneoplastic Syndromes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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