MCID: PRN039
MIFTS: 36

Paraneoplastic Syndromes malady

Summaries for Paraneoplastic Syndromes

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Paraneoplastic syndromes are a group of rare disorders that are triggered by an abnormal immune system response to a cancerous tumor known as a "neoplasm." Paraneoplastic syndromes are thought to happen when cancer-fighting antibodies or white blood cells (known as T cells) mistakenly attack normal cells in the nervous system. These disorders typically affect middle-aged to older people and are most common in individuals with lung, ovarian, lymphatic, or breast cancer. Neurologic symptoms generally develop over a period of days to weeks and usually occur prior to the tumor being discovered. These symptoms may include difficulty in walking or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo or dizziness. Paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis, myasthenia gravis, cerebellar degeneration, limbic or brainstem encephalitis, neuromyotonia, opsoclonus, and sensory neuropathy.

MalaCards: Paraneoplastic Syndromes is related to lung cancer and lung small cell carcinoma. An important gene associated with Paraneoplastic Syndromes is FGF23 (fibroblast growth factor 23), and among its related pathways are Malaria and PAK Pathway. The compounds estrogen and 1,25 dihydroxy vitamin d3 have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and ovary, and related mouse phenotypes are renal/urinary system and respiratory system.

Wikipedia:63 A paraneoplastic syndrome is a disease or symptom that is the consequence of cancer in the body but,... more...

Aliases & Classifications for Paraneoplastic Syndromes

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43NINDS, 44Novoseek, 60UMLS
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Aliases & Descriptions:

paraneoplastic syndromes 43 44 60


Related Diseases for Paraneoplastic Syndromes

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17GeneCards, 18GeneDecks
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Diseases related to Paraneoplastic Syndromes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.8CSF3, CTGF, RCVRN, PTHLH, ENO2, PECAM1
2lung small cell carcinoma30.6ELAVL4, ENO2, PTHLH, RCVRN, CSF3
3hypercalcemia30.5PTHLH, FGF23
4thymoma30.4AIRE, DPYSL5
5ovarian cancer30.4CTGF, CSF3
6adenocarcinoma30.4CTGF, PTHLH, ENO2, PECAM1
7osteomalacia30.2SFRP4, PHEX, MEPE, FGF23, PTHLH
8leukemia30.2PECAM1, THPO, IL6, RCVRN, CSF3
9pancreatitis30.1IL6
10pancreatic cancer30.1CTGF, PTHLH
11thrombocytosis30.1THPO, IL6, CSF3
12sarcoma30.1THPO, ENO2, PECAM1
13melanoma30.1SAG, RCVRN, ENO2, PECAM1
14non-small cell lung carcinoma30.1CSF3, RCVRN, THPO, ENO2, PECAM1
15prostate cancer30.1PECAM1, ENO2, PTHLH, IL6, CTGF, SFRP4
16encephalitis30.0AMPH, DPYSL5, PNMA1
17vasculitis30.0TRIM21, SAG
18peritonitis30.0CTGF, IL6, PECAM1
19adenoma30.0ENO2, SAG
20uveitis29.8SAG, RCVRN
21neuroblastoma29.8ENO2
22arthritis29.8PECAM1, IL6, CTGF
23ischemia29.8PECAM1, CTGF
24small cell carcinoma10.4
25renal cell carcinoma10.4
26squamous cell carcinoma10.4
27breast cancer10.3
28lambert-eaton myasthenic syndrome10.3
29hepatocellular carcinoma10.3
30lung adenocarcinoma10.2
31neuronitis10.2
32paraneoplastic polyneuropathy10.2
33prostatitis10.2
34neuroendocrine carcinoma10.1
35acanthosis nigricans10.1
36adult syndrome10.1
37adult-onset still's disease10.1
38ganglioneuroblastoma10.1
39myasthenia gravis10.1
40thymic carcinoma10.1
41pheochromocytoma10.1
42relapsing polychondritis10.0
43leukemoid reaction10.0
44lymphoepithelioma-like carcinoma10.0
45lymphosarcoma10.0
46bladder carcinoma10.0
47choriocarcinoma10.0
48dermatomyositis10.0
49eosinophilia10.0
50fasciitis10.0

Graphical network of the top 20 diseases related to Paraneoplastic Syndromes:



Diseases related to paraneoplastic syndromes

Clinical Features for Paraneoplastic Syndromes

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Drugs & Therapeutics for Paraneoplastic Syndromes

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Paraneoplastic Syndromes

Drug clinical trials:

Search ClinicalTrials for Paraneoplastic Syndromes

Search NIH Clinical Center for Paraneoplastic Syndromes

Search CenterWatch for Paraneoplastic Syndromes

Genetic Tests for Paraneoplastic Syndromes

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Anatomical Context for Paraneoplastic Syndromes

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32MalaCards
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MalaCards organs/tissues related to Paraneoplastic Syndromes:

32
Lung, Breast, Ovary, T cells

Animal Models for Paraneoplastic Syndromes or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Paraneoplastic Syndromes:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.1PECAM1, FGF23, TRIM21, PHEX, SFRP4
2MP:00053889.7SFRP4, CTGF, AIRE, IL6, PTHLH, ENO2
3MP:00053819.7SFRP4, CTGF, PHEX, AIRE, FGF23, IL6
4MP:00053909.7CTGF, PHEX, MEPE, FGF23, IL6, PTHLH
5MP:00053879.3CSF3, PHEX, MEPE, AIRE, TRIM21, FGF23
6MP:00053849.3PHEX, AIRE, TRIM21, IL6, PTHLH, ENO2
7MP:00053769.3AIRE, PHEX, CTGF, SFRP4, TRIM21, FGF23
8MP:00053979.2CSF3, AIRE, TRIM21, FGF23, IL6, THPO
9MP:00036319.2AMPH, SAG, PHEX, AIRE, DPYSL5, IL6

Publications for Paraneoplastic Syndromes

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Genetic Variations for Paraneoplastic Syndromes

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Expression for genes affiliated with Paraneoplastic Syndromes

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paraneoplastic Syndromes

Search GEO for disease gene expression data for Paraneoplastic Syndromes.

Pathways for genes affiliated with Paraneoplastic Syndromes

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29KEGG, 51QIAGEN
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Pathways related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4PECAM1
2
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10.1CSF3, CTGF, FGF23
310.1THPO, IL6, CSF3
4
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10.0CTGF, FGF23, IL6, THPO
5
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9.9CSF3, CTGF, FGF23, IL6, THPO
6
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9.9THPO, IL6, FGF23, MEPE, CTGF
7
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9.7CTGF, MEPE, FGF23, IL6, THPO, CSF3

Compounds for genes affiliated with Paraneoplastic Syndromes

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6THPO
21,25 dihydroxy vitamin d34410.6PTHLH, FGF23, PHEX
3creatinine4410.6FGF23, THPO, PTHLH
4sodium44 2411.6PHEX, SFRP4
5phosphorus4410.6PTHLH, FGF23, PHEX
6il 114410.5IL6, CSF3
7carbimazole44 1111.5PECAM1, CSF3
8pixy3214410.5CSF3, IL6, THPO
9hydroxyapatite4410.5CTGF, FGF23, PTHLH
10filgrastim44 1111.5CSF3, IL6, THPO
1125-hydroxyvitamin d4410.5SFRP4, FGF23, PTHLH
12mafosfamide4410.5THPO, CSF3
13gm-csf44 2811.5CSF3, IL6, THPO
14heparin44 28 11 2413.5CTGF, FGF23, THPO, PECAM1
15octreotide44 59 28 1113.5FGF23, PTHLH, ENO2
16tgf beta14410.4PTHLH, THPO, IL6, CTGF
17oxygen44 2411.4PECAM1, PTHLH, SAG
18vesnarinone4410.4IL6, CSF3
19agar4410.4PECAM1, PTHLH, THPO, CTGF
20bleomycin44 1111.4CSF3, CTGF, PTHLH
21methylcellulose4410.3CSF3, IL6, THPO, ENO2
22carboplatin44 49 1112.3CSF3, THPO, ENO2
23rantes4410.3CSF3, IL6, THPO, PECAM1
24ribonucleic acid4410.3CTGF, PTHLH, ENO2, PECAM1
25sb 20358044 5911.3THPO, IL6, AIRE, CTGF
26vitamin d4410.3PHEX, FGF23, IL6, PTHLH
27lactate4410.2CTGF, IL6, THPO, PTHLH, ENO2
28cyclosporin a44 28 5912.2SAG, CSF3, CTGF, IL6, PECAM1
29gp 1304410.2THPO, IL6, CSF3
30fibrinogen4410.2CTGF, IL6, THPO, PECAM1
31calcitriol44 59 11 2413.2PTHLH, IL6, FGF23, MEPE, PHEX, SFRP4
32nitric oxide44 11 2412.1CTGF, IL6, THPO, PTHLH, ENO2, PECAM1
33adenylate4410.1SAG, DAZL, THPO, PTHLH, ENO2, ELAVL4
34amifostine44 1111.1THPO, CSF3
35dexamethasone44 49 28 1113.1CSF3, CTGF, IL6, THPO, PTHLH, ENO2
36phospholipid4410.0SAG, RCVRN, PTHLH, PECAM1
37thymidine44 2411.0CSF3, CTGF, IL6, THPO, PTHLH, ENO2
38vegf4410.0CSF3, CTGF, IL6, THPO, PTHLH, ENO2
39pd 98,0594410.0ENO2, THPO, IL6, CTGF
40glucose4410.0CTGF, IL6, THPO, PTHLH, ENO2, PECAM1
41acetylcholine44 49 28 11 2413.9AMPH, THPO, PTHLH, ENO2
42retinoic acid44 2410.9CSF3, CTGF, RCVRN, IL6, THPO, PTHLH
43lipid449.8AMPH, SAG, CTGF, RCVRN, IL6, PTHLH
44p003449.8CTGF, THPO, PECAM1
45tyrosine449.7SAG, CSF3, CTGF, AIRE, FGF23, IL6
46calcium44 49 11 2412.5CTGF, SAG, SFRP4, AMPH, PHEX, FGF23

GO Terms for genes affiliated with Paraneoplastic Syndromes

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16Gene Ontology
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Cellular components related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.5PECAM1, PTHLH, THPO, IL6, FGF23, CTGF

Biological processes related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphate ion homeostasisGO:05506210.3FGF23, SFRP4
2negative regulation of bone mineralizationGO:03050210.2FGF23, MEPE
3negative regulation of neuron deathGO:190121510.2IL6, CSF3
4negative regulation of hormone secretionGO:04688810.2FGF23, IL6
5positive regulation of ERK1 and ERK2 cascadeGO:0703749.9IL6, FGF23, CTGF

Molecular functions related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.9THPO, IL6, FGF23, CTGF, CSF3

Products for genes affiliated with Paraneoplastic Syndromes

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  • Antibodies
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Sources for Paraneoplastic Syndromes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet