Paraneoplastic Syndromes malady

NINDS: Paraneoplastic syndromes are a group of rare disorders that are triggered by an abnormal immune system response to a cancerous tumor known as a "neoplasm." Paraneoplastic syndromes are thought to happen when cancer-fighting antibodies or white blood cells (known as T cells) mistakenly attack normal cells in the nervous system. These disorders typically affect middle-aged to older people and are most common in individuals with lung, ovarian, lymphatic, or breast cancer. Neurologic symptoms generally develop over a period of days to weeks and usually occur prior to the tumor being discovered. These symptoms may include difficulty in walking or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo or dizziness. Paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis, myasthenia gravis, cerebellar degeneration, limbic or brainstem encephalitis, neuromyotonia, opsoclonus, and sensory neuropathy.³¹

MalaCards: Paraneoplastic Syndromes is related to myelitis and lambert-eaton myasthenic syndrome. An important gene associated with Paraneoplastic Syndromes is PNMA1 (paraneoplastic Ma antigen 1), and among its related pathways are 14-3-3 Induced Intracellular Signaling and Glioma Invasiveness. The compounds phosphorus and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include lung, ovary and colon, and related mouse phenotypes are respiratory system and reproductive system.

Wikipedia: A paraneoplastic syndrome is a disease or symptom that is the consequence of the presence of cancer in...⁴⁴ more...

paraneoplastic syndromes 31 32 43

Diseases related to paraneoplastic syndromes by text searches and GeneDecks gene sharing:

(show top 50)    (show all 561)

id	Related Disease	Score	Top Affiliating Genes
1	myelitis	28.7	IL6, AMPH, DPYSL5
2	lambert-eaton myasthenic syndrome	28.3	ENO2, AMPH, ELAVL4
3	oncogenic osteomalacia	27.9	SFRP4, FGF23, FGF7, MEPE, CALCA, PHEX
4	osteomalacia	27.7	SFRP4, FGF23, FGF7, MEPE, CALCA, PTHLH
5	thrombocytosis	27.2	CD79A, IL6, ALB, THPO, CSF3
6	lung adenocarcinoma	26.4	RCVRN, CHKA, CTGF, EGFR, TGFA, PECAM1
7	pheochromocytoma	26.3	VIP, CHKA, IL6, ENO2, CALCA, PTHLH
8	wilms tumor	25.6	FGF7, ENO2, CTGF, EGFR, TGFA, CSF3
9	hypercalcemia	25.5	FGF23, IL2, IL6, ALB, CALCA, PTHLH
10	squamous cell carcinoma	25.4	CHKA, FGF7, ENO2, PTHLH, RHO, EGFR
11	renal cell carcinoma	25.3	CHKA, FGF7, IL2, ENO2, PTHLH, EGFR
12	eosinophilia	25.0	CD79A, IL2, IL5, IL6, ALB, EGFR
13	oral cancer	24.6	SFRP4, CD79A, GSR, MEPE, IL6, ALB
14	glomerulonephritis	24.5	CD79A, GSR, IL2, IL6, ALB, CTGF
15	hepatocellular carcinoma	24.1	SFRP4, VIP, CHKA, GSR, FGF7, IL2
16	lung carcinoma	23.8	RCVRN, CHKA, GSR, FGF7, ENO2, TRB@
17	breast carcinoma	21.8	SFRP4, RCVRN, CHKA, GSR, FGF7, IL2
18	lupus erythematosus	21.6	VIP, CD79A, IL2, IL5, IL6, ALB
19	cervicitis	21.5	VIP, CD79A, GSR, FGF7, IL2, IL5
20	adenoma	21.4	VIP, CHKA, SAG, GSR, IL2, IL5
21	breast cancer	20.9	RCVRN, VIP, CHKA, SAG, GSR, FGF7
22	carcinoma	20.8	SFRP4, RCVRN, VIP, CHKA, CD79A, GSR
23	neuronitis	19.2	SFRP4, RCVRN, VIP, SAG, CD79A, GSR
24	adenocarcinoma	19.2	SFRP4, RCVRN, VIP, CHKA, GSR, FGF7
25	paraneoplastic neurologic disorders	13.7	DAZL, PNMA1, ELAVL4
26	hereditary hypophosphatemic rickets	13.7	SFRP4, FGF23, MEPE
27	familial hypophosphatemia	13.6	FGF23, MEPE, PHEX
28	cyclic thrombocytopenia	13.6	IL6, THPO
29	hypophosphatemic rickets, autosomal dominant	13.6	SFRP4, FGF23, MEPE, PHEX
30	x-linked hypophosphatemia	13.5	FGF23, PHEX
31	limbic encephalitis	13.5	GSR, IL6, AMPH
32	pineocytoma	13.5	SAG, ENO2, RHO
33	persian gulf syndrome	13.4	VIP, PON1
34	primary hyperparathyroidism	13.4	FGF23, CALCA, PTHLH
35	ovarian sex cord tumors	13.4	ENO2, PTHLH, AFP
36	fibrous dysplasia	13.4	FGF23, IL6, CALCA, PTHLH
37	calcinosis	13.4	FGF23, MEPE, CALCA, PHEX
38	secondary syphilis	13.4	FGF23, CALCA, PTHLH, PHEX
39	hypoparathyroidism	13.4	FGF23, CALCA, AIRE, PTHLH
40	familial medullary thyroid carcinoma	13.4	ENO2, CALCA, PTHLH
41	paraproteinemia	13.3	CD79A, IL6
42	somatostatinoma	13.3	VIP, ENO2, CALCA
43	pseudohypoparathyroidism	13.3	CHKA, CALCA, PTHLH
44	coronary stenosis	13.3	IL6, PON1, PECAM1
45	wdha syndrome	13.3	VIP, CALCA
46	craniopharyngioma	13.3	CHKA, IL6, CALCA, PTHLH
47	gastroschisis	13.3	IL6, NPPA, AFP
48	ocular cicatricial pemphigoid	13.2	CD79A, IL5, CTGF
49	glucagonoma	13.2	VIP, ENO2, CALCA
50	asbestosis	13.2	IL6, ENO2, TGFA

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to paraneoplastic syndromes:

²²

MGI Mouse Phenotypes related to paraneoplastic syndromes:

²⁵ (show all 15)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.1	SFRP4, FGF23, CALCA
2	reproductive system phenotype	MP:0005389	9.5	ELAVL4, AFP, DAZL, AMPH, IL6, FGF23
3	renal/urinary system phenotype	MP:0005367	9.1	NPPA, EGFR, PHEX, PTHLH, FGF23, TRIM21
4	hematopoietic system phenotype	MP:0005397	9.0	CSF3, FGF23, FGF7, IL5, TRB@, TRIM21
5	liver/biliary system phenotype	MP:0005370	8.5	TRB@, AIRE, IL6, IL2, CHKA, EGFR
6	nervous system phenotype	MP:0003631	8.2	EGFR, FGF7, GRIK1, AMPH, AIRE, PTHLH
7	integument phenotype	MP:0010771	8.1	CSF3, TGFA, PTHLH, TRIM21, TRB@, CALCA
8	digestive/alimentary phenotype	MP:0005381	8.1	TRB@, PHEX, PECAM1, TGFA, FGF23, SFRP4
9	vision/eye phenotype	MP:0005391	7.8	RCVRN, TGFA, IL6, AIRE, EGFR, PTHLH
10	skeleton phenotype	MP:0005390	7.5	MEPE, CTGF, PLAT, PHEX, EGFR, TGFA
11	behavior/neurological phenotype	MP:0005386	7.1	IL2, GRIK1, VIP, IL5, IL6, ENO2
12	immune system phenotype	MP:0005387	7.1	PTHLH, PLAT, PHEX, EGFR, PECAM1, CD79A
13	cardiovascular system phenotype	MP:0005385	6.3	SFRP4, GSR, CTGF, PON1, NPPA, PECAM1
14	cellular phenotype	MP:0005384	6.2	PECAM1, AIRE, IL6, IL2, CD79A, PON1
15	homeostasis/metabolism phenotype	MP:0005376	4.1	FGF7, PON1, EGFR, RHO, PHEX, PLAT

Articles related to paraneoplastic syndromes:

(show all 35)

id	Title	Authors	Year	Affiliating Genes
1	Transverse myelitis: amphiphysin autoimmunity paraneoplastic syndrome in a woman with breast cancer. (19398941)	Virani S.... Abraham J.	2009	AMPH
2	Superior vena cava syndrome arising from subclavian vein port catheter implantation and paraneoplastic syndrome. (19404035)	DaA9delen S.	2009	PLAT
3	Oncogenic osteomalacia, a rare paraneoplastic syndrome due to phosphate wasting--a case report and review of the literature. (19000546)	Woznowski M.... Buchner N.	2008	FGF7, SFRP4, FGF23
4	Hypothetical review: thymic aberrations and type-I interferons; attempts to deduce autoimmunizing mechanisms from unexpected clues in monogenic and paraneoplastic syndromes. (18727623)	Meager A.... Willcox N.	2008	AIRE
5	Paraoxonase 1 (PON1) status in gastroesophageal malignancies and associated paraneoplastic syndromes - connection with inflammation. (18423402)	Krzystek-Korpacka M.... Gamian A.	2008	PON1
6	Non-small-cell lung cancer associated with excessive eosinophilia and secretion of interleukin-5 as a paraneoplastic syndrome. (17160990)	Pandit R.... Dimitrov N.	2007	IL5
7	Paraneoplastic syndromes in neuro-ophthalmology. (18162997)	Alabduljalil T.... Behbehani R.	2007	RHO, SAG, IMMT
8	Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes. (16083340)	Barton B.E.	2005	IL6
9	The incidence and clinical significance of paraneoplastic syndromes in patients with hepatocellular carcinoma (16177554)	Huh U.Y.... Chang R.	2005	AFP
10	Neuro-ophthalmology and paraneoplastic syndromes. (15090871)	Bataller L.... Dalmau J.	2004	RCVRN
11	Thrombocytosis: a paraneoplastic syndrome in patients with hepatocellular carcinoma. (15300887)	Hwang S.J.... Lee S.D.	2004	THPO
12	Paraneoplastic syndromes associated with visual loss. (14615650)	Ling C.P.... Pavesio C.	2003	RCVRN
13	Paraneoplastic syndromes in ganglioneuroblastoma: contrasting symptoms of constipation and diarrhoea. (12739135)	Wildhaber B.... Sacher P.	2003	VIP
14	Amphiphysin paraneoplastic syndrome: a delayed diagnosis of breast carcinoma. (12846868)	Georgian-Smith D.... Kraft G.H.	2003	AMPH
15	A case of pseudoscleroderma as paraneoplastic syndrome due to carcinoma of cervical uteri (14635403)	Yamamoto M.... Imai K.	2003	CTGF
16	Atypical paraneoplastic syndrome associated with anti -Yo antibodies. (12809356)	Finsterer J.... Drlicek M.	2003	CHKA
17	Identification of the amino acids on a neuronal glutamate receptor recognized by an autoantibody from a patient with paraneoplastic syndrome. (11241583)	Carlson N.G.... Rogers S.W.	2001	GSR, GRIK1
18	Identification of human antitumor cytotoxic T lymphocytes epitopes of recoverin, a cancer-associated retinopathy antigen, possibly related with a better prognosis in a paraneoplastic syndrome. (11180121)	Maeda A.... Sato N.	2001	RCVRN
19	Paraneoplastic syndrome in the course of lung adenocarcinoma: morphological picture and immunohistochemical analysis of the inflammatory infiltrates and PECAM-1 expression. (11057031)	Dziewulska D.... RafaA8owska J.	2000	PECAM1
20	Paraneoplastic syndromes in patients with hepatocellular carcinoma in Taiwan. (10463978)	Luo J.C.... Lee S.D.	1999	AFP
21	Cutaneous paraneoplastic syndrome as an immunologic phenomenon exemplified by paraneoplastic subacute cutaneous lupus erythematosus (10584550)	TrA1eb R.F.... TrA1eb R.M.	1999	TRIM21
22	Serum interleukin-6 levels in metastatic renal cell carcinoma before treatment with interleukin-2 correlates with paraneoplastic syndromes but not patient survival. (9474133)	Walther M.M.... Rosenberg S.A.	1998	IL6, IL2, ALB
23	Glomerulonephritis associated with basaloid squamous cell carcinoma of the oesophagus. A possible unusual paraneoplastic syndrome. (9561579)	Lam K.Y.... Yuen M.C.	1998	CD79A
24	Stiff-man syndrome in a woman with breast cancer: an uncommon central nervous system paraneoplastic syndrome. (9443464)	Rosin L.... Meinck H.M.	1998	AMPH
25	Transforming growth factor-alpha (TGF alpha)-producing gastric carcinoma with acanthosis nigricans: an endocrine effect of TGF alpha in the pathogenesis of cutaneous paraneoplastic syndrome and epithelial hyperplasia of the esophagus. (9058298)	Koyama S.... Fujiwara K.	1997	TGFA
26	Triple paraneoplastic syndrome of hypercalcemia, leukocytosis and cachexia in two human tumor xenografts in nude mice. (8609700)	Tanaka R.... Yamaguchi K.	1996	PTHLH
27	Non-small-cell lung cancer with multiple paraneoplastic syndromes. (7589410)	Monsieur I.... Vincken W.	1995	CALCA
28	Establishment and characterization of a human small cell lung carcinoma cell line (MT-428) derived from the patient who showed neur ological paraneoplastic syndrome (8025019)	Yamaji Y.... Irino S.	1994	ENO2
29	Serum biological markers and paraneoplastic syndromes in Wilms tumor. (8383282)	Coppes M.J.	1993	ENO2
30	Mechanisms of paraneoplastic syndromes of colon-26: involvement of interleukin 6 in hypercalcemia. (8142602)	Strassmann G.... Bertolini D.R.	1993	IL6
31	Pheochromocytoma with pyrexia and marked inflammatory signs: a paraneoplastic syndrome with possible relation to interleukin-6 production. (1890158)	Fukumoto S.... Ogata E.	1991	IL6
32	Metabolic disturbance as paraneoplastic syndrome (1825908)	Ariyoshi Y.	1991	PTHLH, NPPA
33	Dependence of a human squamous carcinoma and associated paraneoplastic syndromes on the epidermal growth factor receptor pathway in nude mice. (2015605)	Yoneda T.... Mundy G.R.	1991	EGFR
34	Concurrent eosinophilic fasciitis and cutaneous T-cel l lymphoma. Eosinophilic fasciitis as a paraneoplastic syndrome of T-cell malig nant neoplasms? (2036034)	Chan L.S.... Cooper K.D.	1991	TRB@
35	Studies on the pathophysiology of paraneoplastic syndromes: both cancer cells and host immune cells are responsible for the pathophysiology of leukocytosis associated with oral cancer (1725787)	Nishimura R.	1990	CSF3

Genes related to paraneoplastic syndromes according to GeneCards:

(show all 39)

id	Symbol	Description	Score	GeneCards Section Context
1	PNMA1	paraneoplastic Ma antigen 1	11.0	Summaries
2	DPYSL5	dihydropyrimidinase-like 5	11.0	Summaries
3	RCVRN	recoverin	11.0	Publications
4	DAZL	deleted in azoospermia-like	11.0
5	FGF23	fibroblast growth factor 23	11.0	Publications
6	AMPH	amphiphysin	11.0	Publications
7	CTGF	connective tissue growth factor	11.0	Publications
8	PTHLH	parathyroid hormone-like hormone	11.0	Publications
9	ELAVL4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4	11.0
10	PHEX	phosphate regulating endopeptidase homolog, X-linked	11.0
11	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
12	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
13	MEPE	matrix extracellular phosphoglycoprotein	11.0	Publications
14	SFRP4	secreted frizzled-related protein 4	11.0	Publications
15	IMMT	inner membrane protein, mitochondrial	11.0	Publications
16	AIRE	autoimmune regulator	11.0	Publications
17	FGF7	fibroblast growth factor 7	11.0	Publications
18	TRIM21	tripartite motif containing 21	11.0	Publications
19	SAG	S-antigen; retina and pineal gland (arrestin)	11.0	Publications
20	THPO	thrombopoietin	11.0	Publications
21	PECAM1	platelet/endothelial cell adhesion molecule 1	11.0	Publications
22	VIP	vasoactive intestinal peptide	11.0	Publications
23	RHO	rhodopsin	11.0	Publications
24	CHKA	choline kinase alpha	11.0	Publications
25	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
26	PON1	paraoxonase 1	11.0	Publications
27	GRIK1	glutamate receptor, ionotropic, kainate 1	11.0	Publications
28	AFP	alpha-fetoprotein	11.0	Publications
29	GSR	glutathione reductase	11.0	Publications
30	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
31	TRB@	T cell receptor beta locus	11.0	Publications
32	TGFA	transforming growth factor, alpha	11.0	Publications
33	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
34	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
35	NPPA	natriuretic peptide A	11.0	Publications
36	PLAT	plasminogen activator, tissue	11.0	Publications
37	IL2	interleukin 2	11.0	Publications
38	ALB	albumin	11.0	Publications
39	EGFR	epidermal growth factor receptor	11.0	Publications

Pathways related to paraneoplastic syndromes according to GeneDecks:

(show top 50)    (show all 58)

id	Pathway	Score	Top Affiliating Genes
1	14-3-3 Induced Intracellular Signaling36	10.2	FGF7, FGF23, THPO, CTGF
2	Glioma Invasiveness36	9.9	FGF7, THPO, TGFA, FGF23
3	Actin-Based Motility by Rho Family GTPases36	9.6	IL2, FGF23, CTGF, THPO, FGF7
4	Rac1 Pathway36	9.5	CTGF, IL6, IL2, FGF23, THPO, FGF7
5	Akt Signaling36	9.5	FGF23, CTGF, IL6, IL2, THPO, FGF7
6	Ras Pathway36	9.5	TGFA, EGFR, CTGF, FGF7, FGF23
7	JNK Pathway36	9.4	FGF7, THPO, IL2, IL6
8	Paxillin Interactions36	9.4	FGF7, EGFR, TGFA, THPO, FGF23, CTGF
9	ILK Signaling36	9.2	MEPE, CTGF, FGF7, EGFR, TGFA, FGF23
10	Rho Family GTPases36	9.1	CTGF, THPO, CSF3, IL2, FGF23, FGF7
11	PPAR Pathway36	9.0	IL2, FGF23, IL6, CTGF, EGFR, THPO
12	PTEN Pathway36	9.0	MEPE, CTGF, THPO, EGFR, FGF23, FGF7
13	eNOS Signaling36	8.7	EGFR, FGF23, IL2, THPO, TGFA, FGF7
14	Apoptotic Pathways in Synovial Fibroblasts36	8.7	THPO, EGFR, TGFA, IL6, CTGF, FGF23
15	p53 Mediated Apoptosis36	8.7	CTGF, IL2, FGF7, FGF23, TGFA, THPO
16	Telomerase Components in Cell Signaling36	8.7	TGFA, FGF23, FGF7, IL2, IL6, CTGF
17	Mitochondrial Apoptosis36	8.7	FGF7, FGF23, TGFA, THPO, EGFR, CTGF
18	NF-KappaB (p50-p65) Pathway36	8.7	TGFA, THPO, EGFR, CTGF, IL6, IL2
19	DHA Signaling36	8.7	IL6, FGF23, TGFA, THPO, EGFR, FGF7
20	mTOR Pathway36	8.7	IL6, CTGF, TGFA, THPO, IL2, FGF7
21	NF-KappaB Family Pathway36	8.7	IL2, IL6, CTGF, THPO, TGFA, FGF23
22	ERK5 Signaling36	8.7	CTGF, TGFA, EGFR, IL6, IL2, FGF7
23	Cellular Apoptosis Pathway36	8.7	TGFA, THPO, EGFR, CTGF, IL6, IL2
24	eIF2 Pathway36	8.7	FGF23, THPO, EGFR, FGF7, IL2, IL6
25	Nanog in Mammalian ESC Pluripotency36	8.7	CTGF, IL6, FGF23, IL2, THPO, TGFA
26	Nuclear Receptor Activation by Vitamin-A36	8.6	IL6, TGFA, EGFR, CTGF, FGF7, FGF23
27	p70S6K Signaling36	8.6	FGF23, FGF7, IL2, IL6, CTGF, EGFR
28	Activation of PKC through GPCR36	8.6	FGF23, IL6, CTGF, EGFR, TGFA, FGF7
29	Renin-Angiotensin Pathway36	8.6	FGF7, EGFR, FGF23, TGFA, THPO, IL2
30	Rap1 Pathway36	8.6	TGFA, FGF7, IL2, IL6, CTGF, EGFR
31	Pancreatic Adenocarcinoma36	8.5	FGF23, IL6, TGFA, THPO, EGFR, CTGF
32	CREB Pathway36	8.4	EGFR, CTGF, IL6, IL2, FGF7, GRIK1
33	Epithelial Adherens Junctions36	8.4	IL2, EGFR, FGF23, IL6, CTGF, THPO
34	IP3 Pathway36	8.4	FGF7, FGF23, CD79A, CTGF, THPO, EGFR
35	GSK3 Signaling36	8.4	TGFA, FGF23, FGF7, IL2, CTGF, EGFR
36	NFAT in Immune Response36	8.4	IL6, CD79A, FGF23, FGF7, IL2, CTGF
37	Estrogen Pathway36	8.4	CTGF, EGFR, FGF7, TGFA, FGF23, THPO
38	GPCR Pathway36	8.3	CTGF, TGFA, THPO, EGFR, IL6, IL2
39	TGF-Beta Pathway36	8.3	IL2, FGF7, FGF23, IL5, TGFA, THPO
40	Intracellular Calcium Signaling36	8.3	THPO, EGFR, FGF23, FGF7, GRIK1, IL2
41	Molecular Mechanisms of Cancer36	8.3	IL2, EGFR, TGFA, MEPE, IL6, FGF23
42	Phospholipase-C Pathway36	8.2	TGFA, CD79A, FGF23, MEPE, CTGF, EGFR
43	MAPK Family Pathway36	8.2	EGFR, FGF23, FGF7, IL2, IL5, IL6
44	JAK-STAT Pathway36	8.2	CTGF, EGFR, IL6, IL5, IL2, FGF7
45	Tec Kinases Signaling36	8.2	THPO, EGFR, CTGF, IL6, TGFA, IL5
46	PAK Pathway36	8.2	FGF7, IL5, IL6, CTGF, EGFR, THPO
47	Antioxidant Action of Vitamin-C36	8.1	TGFA, THPO, EGFR, CSF3, IL2, CTGF
48	p38 Signaling36	8.1	EGFR, IL6, IL2, CTGF, THPO, FGF23
49	ERK Signaling36	8.0	CSF3, TGFA, EGFR, THPO, FGF23, FGF7
50	MAPK Signaling36	7.8	IL6, FGF23, TGFA, FGF7, THPO, MEPE

Compounds related to paraneoplastic syndromes according to GeneDecks:

(show top 50)    (show all 182)

id	Compound	Score	Top Affiliating Genes
1	phosphorus32	10.0	PHEX, FGF23, CHKA, CALCA
2	cyclophosphamide32 34 9 9	12.9	TRB@
3	agar32	9.8	CTGF, AFP, TGFA, THPO, FGF7
4	aspartate32	9.6	RHO, PHEX, FGF7, GSR, SAG, VIP
5	polyethylene glycol32	9.6	PON1, VIP, NPPA, AFP
6	h2o232	9.5	THPO, VIP, CD79A, IL5, PON1
7	bleomycin32 9 9	11.2	CSF3, PTHLH, AFP, IL5, FGF7, CTGF
8	tgf beta132	9.1	THPO, IL6, PTHLH, FGF7, CTGF, AFP
9	gm-csf32	9.0	IL5, IL2, THPO, IL6, TGFA, CSF3
10	simvastatin32 34 42 9 18 9	14.0	PLAT, CTGF, AFP, PON1, PTHLH, IL6
11	carboplatin32 34 9 9	11.9	CSF3, EGFR, ENO2, GSR, AFP, THPO
12	phosphatidylcholine32	8.9	PON1, VIP, RHO, CHKA, PTHLH, CALCA
13	betacarotene32	8.9	CHKA, PON1, EGFR, RHO, GSR, CD79A
14	pge232	8.8	GSR, SAG, IL5, EGFR, TGFA, VIP
15	creatinine32	8.8	CHKA, AFP, PON1, TGFA, CTGF, FGF23
16	epinephrine32 9 18 9	11.6	NPPA, THPO, TGFA, RHO, GSR, CD79A
17	rantes32	8.5	THPO, VIP, FGF7, IL2, IL5, IL6
18	prostacyclin32	8.5	VIP, CTGF, PLAT, RHO, TGFA, NPPA
19	captopril32 42 9 9	11.5	VIP, CD79A, ALB, CALCA, CTGF, NPPA
20	hydrocortisone32 9 9	10.5	PTHLH, TGFA, CALCA, IL5, IL2, IL6
21	glutamine32	8.4	TGFA, VIP, PON1, FGF7, SAG, AFP
22	vegf32	8.3	THPO, PECAM1, NPPA, AFP, RHO, CTGF
23	fibrinogen32	8.2	IL6, ALB, CTGF, THPO, PON1, PECAM1
24	acetylcholine32 9 18 9	11.2	ENO2, CD79A, CHKA, VIP, AMPH, THPO
25	prednisolone32 9 9	10.1	CSF3, PTHLH, ALB, IL6, IL2, CD79A
26	glutamate32	8.0	AMPH, TGFA, RHO, VIP, CHKA, CD79A
27	heparin32 9 18 9	11.0	SAG, PTHLH, CD79A, ENO2, ALB, AFP
28	calcitriol32 42 9 18 9	11.9	IL6, CALCA, PTHLH, PHEX, IL2, TGFA
29	methotrexate32 34 42 9 9	11.9	CSF3, ALB, ENO2, IL6, IL5, CD79A
30	cysteine32	7.9	TGFA, RCVRN, CD79A, FGF7, IL5, ALB
31	actinomycin d32	7.8	THPO, TGFA, PECAM1, AFP, PLAT, PTHLH
32	testosterone32 9 18 9	10.7	CHKA, CALCA, VIP, CD79A, FGF7, IL5
33	dexamethasone32 42 34 9 9	11.7	CHKA, CD79A, CTGF, PTHLH, VIP, ENO2
34	estrogen32	7.7	AFP, NPPA, PON1, TGFA, CTGF, CALCA
35	thymidine32 18	8.5	PECAM1, AFP, CSF3, THPO, VIP, CHKA
36	vitamin d32	7.5	PHEX, CALCA, ALB, CHKA, IL5, TGFA
37	cycloheximide32	7.4	PLAT, TGFA, CSF3, PECAM1, CTGF, PTHLH
38	adenylate32	7.4	CALCA, ENO2, IL5, VIP, CHKA, SAG
39	lipid32	7.4	CTGF, RCVRN, CHKA, SAG, IL6, GSR
40	lactate32	7.3	ALB, ENO2, CD79A, AFP, GSR, CHKA
41	paraffin32	7.2	PTHLH, PLAT, EGFR, TGFA, PECAM1, AFP
42	calcium32 9 18 9	10.2	CTGF, TRB@, AFP, SFRP4, PECAM1, THPO
43	thyroxine32 18	8.1	CALCA, VIP, CHKA, CD79A, PTHLH, IL5
44	cyclosporin a32 42	8.1	VIP, TRB@, PLAT, TGFA, NPPA, SAG
45	alanine32	7.1	RHO, GSR, PTHLH, TGFA, ALB, ENO2
46	retinoic acid32 42 18	8.7	IL5, PLAT, TGFA, THPO, EGFR, PTHLH
47	histamine32 18	7.4	ALB, PLAT, CD79A, VIP, CALCA, RHO
48	indomethacin32 9 9	8.4	THPO, TGFA, IL2, IL6, ENO2, ALB
49	tyrosine32	6.2	AFP, FGF7, CHKA, SAG, FGF23, IL2
50	serine32	6.2	IL2, IL5, AIRE, CHKA, PTHLH, CTGF

Cellular components related to paraneoplastic syndromes according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	6.2	FGF23, FGF7, IL2, IL5, IL6, ALB
2	extracellular space	GO:005615	4.7	AFP, IL5, IL6, ALB, CALCA, PTHLH

Biological processes related to paraneoplastic syndromes according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	rhodopsin mediated phototransduction	GO:009586	10.1	SAG, RHO
2	rhodopsin mediated signaling pathway	GO:016056	9.8	SAG, RHO
3	positive regulation of immunoglobulin secretion	GO:051024	9.2	IL5, IL2, IL6
4	positive regulation of cell proliferation	GO:008284	8.3	VIP, CSF3, THPO, EGFR, CTGF, PTHLH

Molecular functions related to paraneoplastic syndromes according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:005125	9.0	CSF3, THPO, IL6, IL5, IL2
2	hormone activity	GO:005179	8.8	NPPA, THPO, PTHLH, CALCA, VIP
3	growth factor activity	GO:008083	8.1	CSF3, TGFA, THPO, CTGF, IL6, IL5