MCID: PRN039
MIFTS: 45

Paraneoplastic Syndromes malady

Summaries for Paraneoplastic Syndromes

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Paraneoplastic syndromes are a group of rare disorders that are triggered by an abnormal immune system response to a cancerous tumor known as a "neoplasm." Paraneoplastic syndromes are thought to happen when cancer-fighting antibodies or white blood cells (known as T cells) mistakenly attack normal cells in the nervous system. These disorders typically affect middle-aged to older people and are most common in individuals with lung, ovarian, lymphatic, or breast cancer. Neurologic symptoms generally develop over a period of days to weeks and usually occur prior to the tumor being discovered. These symptoms may include difficulty in walking or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo or dizziness. Paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis, myasthenia gravis, cerebellar degeneration, limbic or brainstem encephalitis, neuromyotonia, opsoclonus, and sensory neuropathy.

MalaCards: Paraneoplastic Syndromes is related to hypercalcemia and thymoma. An important gene associated with Paraneoplastic Syndromes is FGF23 (fibroblast growth factor 23), and among its related pathways are Malaria and PAK Pathway. The compounds estrogen and 1,25 dihydroxy vitamin d3 have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and spinal cord, and related mouse phenotypes are renal/urinary system and respiratory system.

Wikipedia:64 A paraneoplastic syndrome is a disease or symptom that is the consequence of the presence of cancer in... more...

Aliases & Classifications for Paraneoplastic Syndromes

Sources:
44NINDS, 45Novoseek, 61UMLS
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Aliases & Descriptions:

paraneoplastic syndromes 44 45 61


Related Diseases for Paraneoplastic Syndromes

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Paraneoplastic Syndromes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1hypercalcemia30.5PTHLH, FGF23
2thymoma30.4AIRE, DPYSL5
3adenocarcinoma30.4CTGF, PTHLH, ENO2, PECAM1
4osteomalacia30.3SFRP4, PHEX, MEPE, FGF23, PTHLH
5thrombocytosis30.2THPO, IL6, CSF3
6vasculitis30.0TRIM21, SAG
7adenoma30.0ENO2, SAG
8uveitis29.8SAG, RCVRN
9arthritis29.8PECAM1, IL6, CTGF
10n syndrome10.9
11small cell carcinoma10.4
12squamous cell carcinoma10.4
13lambert-eaton myasthenic syndrome10.3
14lambert syndrome10.3
15paraneoplastic cerebellar degeneration10.3
16cerebellar degeneration10.2
17paraneoplastic polyneuropathy10.2
18oral cancer10.2
19neuroendocrine carcinoma10.1
20acanthosis nigricans10.1
21adult syndrome10.1
22conn's syndrome10.1
23adult-onset still's disease10.1
24thymic carcinoma10.1
25pheochromocytoma10.1
26char syndrome10.1
27cerebellar degeneration, subacute10.1
28oncogenic osteomalacia10.1
29polymyositis10.1
30relapsing polychondritis10.0
31leukemoid reaction10.0
32lymphosarcoma10.0
33bladder carcinoma10.0
34hypereosinophilic syndrome10.0
35kid syndrome10.0
36myelodysplastic syndromes10.0
37foot drop10.0
38blindness10.0RCVRN
39adult t-cell leukemia10.0PTHLH
40fibrous dysplasia10.0FGF23
41hepatitis10.0AIRE
42neuropathy10.0DPYSL5
43calcinosis10.0FGF23
44optic neuritis10.0RCVRN
45viral hepatitis10.0CTGF
46retinitis10.0SAG
47hyperthyroidism10.0FGF23
48down syndrome10.0AIRE
49pancreatitis10.0IL6
50systemic scleroderma10.0CTGF

Graphical network of the top 20 diseases related to Paraneoplastic Syndromes:



Diseases related to paraneoplastic syndromes

Clinical Features for Paraneoplastic Syndromes

Drugs & Therapeutics for Paraneoplastic Syndromes

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Paraneoplastic Syndromes

Drug clinical trials:

Search ClinicalTrials for Paraneoplastic Syndromes

Search NIH Clinical Center for Paraneoplastic Syndromes

Search CenterWatch for Paraneoplastic Syndromes

Genetic Tests for Paraneoplastic Syndromes

Anatomical Context for Paraneoplastic Syndromes

Sources:
33MalaCards
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MalaCards organs/tissues related to Paraneoplastic Syndromes:

33
Ovary, Liver, Spinal cord, Brain, Kidney, Lung, Colon, Thyroid, Breast, Prostate, Myeloid, T cells

Animal Models for Paraneoplastic Syndromes or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Paraneoplastic Syndromes

Sources:
51PubMed
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Articles related to Paraneoplastic Syndromes:

(show top 50)    (show all 277)
idTitleAuthorsYear
1
Paraneoplastic syndromes and autoimmune encephalitis: Five new things. (23634368)
2012
2
Unusual paraneoplastic syndromes of breast carcinoma: a combination of cerebellar degeneration and Lambert-Eaton Myasthenic Syndrome. (19005633)
2011
3
Paraneoplastic syndromes causing movement disorders. (21496591)
2011
4
Cerebrospinal fluid study in paraneoplastic syndromes. (19324868)
2010
5
HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes. (20547426)
2010
6
Paraneoplastic syndromes and the kidney. (20228504)
2010
7
Hypothetical review: thymic aberrations and type-I interferons; attempts to deduce autoimmunizing mechanisms from unexpected clues in monogenic and paraneoplastic syndromes. (18727623)
2008
8
Paraneoplastic syndromes of the CNS. (18339348)
2008
9
Neuro-ophthalmologic manifestations of paraneoplastic syndromes. (18347462)
2008
10
Neurologic paraneoplastic syndromes. (14664757)
2004
11
Immunological features of neurological paraneoplastic syndromes. (15171814)
2004
12
Some unusual paraneoplastic syndromes. Case 4. Paraneoplastic nephrotic syndrome in a patient with lung cancer. (12829687)
2003
13
Some unusual paraneoplastic syndromes. Case 2. Digital ulceration as a paraneoplastic syndrome in ovarian cancer. (12829684)
2003
14
New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes. (11179499)
2001
15
FDG-PET imaging in patients with paraneoplastic syndromes and suspected small cell lung cancer. (11292210)
2001
16
Paraneoplastic syndromes associated with anti-Hu antibodies. (11344832)
2001
17
Peptide neurotoxins, small-cell lung carcinoma andneurological paraneoplastic syndromes. (11086222)
2000
18
Paraneoplastic syndromes in patients with laryngeal and hypopharyngeal cancers. (10651424)
2000
19
Paraneoplastic syndromes of leukocytosis, thrombocytosis, and hypercalcemia associated with squamous cell carcinoma. (10405479)
1999
20
Mechanisms of paraneoplastic syndromes in mice bearing a spontaneous lung adenocarcinoma. (10567876)
1999
21
Paraneoplastic syndromes in patients with hepatocellular carcinoma in Taiwan. (10463978)
1999
22
Paraneoplastic syndromes. (10219742)
1999
23
Serum interleukin-6 levels in metastatic renal cell carcinoma before treatment with interleukin-2 correlates with paraneoplastic syndromes but not patient survival. (9474133)
1998
24
Immunoadsorption therapy for paraneoplastic syndromes. (9892095)
1998
25
Peripheral neurological paraneoplastic syndromes. (14988762)
1998
26
Paraneoplastic syndromes affecting the nervous system. (9208887)
1997
27
Mucocutaneous paraneoplastic syndromes. (9208889)
1997
28
Oculomucocutaneous changes as paraneoplastic syndromes. (8803581)
1996
29
Cutaneous paraneoplastic syndromes and genodermatoses with malignant potential. (7915473)
1994
30
Paraneoplastic syndromes in primary liver cell carcinoma in Nigeria. (8165731)
1994
31
Cutaneous paraneoplastic syndromes associated with lung cancer. (8497142)
1993
32
Comparative dermatology: veterinary cutaneous paraneoplastic syndromes. (8339191)
1993
33
Paraneoplastic syndromes: fads and facts (1) and neurological manifestations of malignant diseases (2) (1452572)
1992
34
Paraneoplastic syndromes in lung cancer. (1591305)
1992
35
Clinical and pathological advances on central nervous system paraneoplastic syndromes. (1448670)
1992
36
Paraneoplastic syndromes: fads and facts. (1960150)
1991
37
Mechanism of host cell membrane modification by tumour: a model for paraneoplastic syndromes. (1714881)
1990
38
Paraneoplastic syndromes. (2190065)
1990
39
Paraneoplastic syndromes. (2183311)
1990
40
Clinical management of tumours in geriatric dogs and cats: systemic effects of tumours and paraneoplastic syndromes. (2368262)
1990
41
Studies on the pathophysiology of paraneoplastic syndromes: both cancer cells and host immune cells are responsible for the pathophysiology of leukocytosis associated with oral cancer]. (1725787)
1990
42
Autoantibodies in paraneoplastic syndromes associated with small-cell lung cancer. (2842702)
1988
43
Paraneoplastic syndromes associated with prostatic carcinoma. (3312637)
1987
44
Paraneoplastic syndromes in hypernephroma. (3306861)
1987
45
Neurological paraneoplastic syndromes. (4024635)
1985
46
Paraneoplastic syndromes of the dog. (117002)
1979
47
Paraneoplastic syndromes: unusual manifestations of malignant disease. (255402)
1979
48
A review of paraneoplastic syndromes associated with tumors of the gastrointestinal tract, liver, colon, and other commonly encountered sites. (274599)
1978
49
The paraneoplastic syndromes associated with carcinoma of the thyroid gland. (4362924)
1974
50
The paraneoplastic syndromes. (4992883)
1968

Genetic Variations for Paraneoplastic Syndromes

Expression for genes affiliated with Paraneoplastic Syndromes

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paraneoplastic Syndromes

Search GEO for disease gene expression data for Paraneoplastic Syndromes.

Pathways for genes affiliated with Paraneoplastic Syndromes

Sources:
30KEGG, 52QIAGEN
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Pathways related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4PECAM1
2
Hide members
10.1CSF3, CTGF, FGF23
310.1CSF3, THPO, IL6
4
Hide members
10.0IL6, FGF23, CTGF, THPO
5
Hide members
9.9IL6, FGF23, CSF3, THPO, CTGF
6
Hide members
9.9THPO, CTGF, MEPE, FGF23, IL6
7
Hide members
9.7FGF23, IL6, CSF3, MEPE, CTGF, THPO

Compounds for genes affiliated with Paraneoplastic Syndromes

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB
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Compounds related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6THPO
21,25 dihydroxy vitamin d34510.6PTHLH, FGF23, PHEX
3creatinine4510.6FGF23, THPO, PTHLH
4sodium45 2411.6PHEX, SFRP4
5phosphorus4510.6PTHLH, FGF23, PHEX
6il 114510.5IL6, CSF3
7carbimazole45 1111.5PECAM1, CSF3
8pixy3214510.5CSF3, IL6, THPO
9hydroxyapatite4510.5CTGF, FGF23, PTHLH
10filgrastim45 1111.5CSF3, IL6, THPO
1125-hydroxyvitamin d4510.5SFRP4, FGF23, PTHLH
12mafosfamide4510.5THPO, CSF3
13gm-csf45 2911.5CSF3, IL6, THPO
14heparin45 29 11 2413.5CTGF, FGF23, THPO, PECAM1
15octreotide45 60 29 1113.5FGF23, PTHLH, ENO2
16tgf beta14510.4PTHLH, THPO, IL6, CTGF
17oxygen45 2411.4PECAM1, PTHLH, SAG
18vesnarinone4510.4IL6, CSF3
19agar4510.4PECAM1, PTHLH, THPO, CTGF
20bleomycin45 1111.4CSF3, CTGF, PTHLH
21methylcellulose4510.3CSF3, IL6, THPO, ENO2
22carboplatin45 50 1112.3CSF3, THPO, ENO2
23rantes4510.3CSF3, IL6, THPO, PECAM1
24ribonucleic acid4510.3CTGF, PTHLH, ENO2, PECAM1
25sb 20358045 6011.3THPO, IL6, AIRE, CTGF
26vitamin d4510.3PHEX, FGF23, IL6, PTHLH
27lactate4510.2CTGF, IL6, THPO, PTHLH, ENO2
28cyclosporin a45 29 6012.2SAG, CSF3, CTGF, IL6, PECAM1
29gp 1304510.2THPO, IL6, CSF3
30fibrinogen4510.2CTGF, IL6, THPO, PECAM1
31calcitriol45 60 11 2413.2PTHLH, IL6, FGF23, MEPE, PHEX, SFRP4
32nitric oxide45 11 2412.1CTGF, IL6, THPO, PTHLH, ENO2, PECAM1
33adenylate4510.1SAG, DAZL, THPO, PTHLH, ENO2, ELAVL4
34amifostine45 1111.1THPO, CSF3
35dexamethasone45 50 29 1113.1CSF3, CTGF, IL6, THPO, PTHLH, ENO2
36phospholipid4510.0SAG, RCVRN, PTHLH, PECAM1
37thymidine45 2411.0CSF3, CTGF, IL6, THPO, PTHLH, ENO2
38vegf4510.0CSF3, CTGF, IL6, THPO, PTHLH, ENO2
39pd 98,0594510.0ENO2, THPO, IL6, CTGF
40glucose4510.0CTGF, IL6, THPO, PTHLH, ENO2, PECAM1
41acetylcholine45 50 29 11 2413.9AMPH, THPO, PTHLH, ENO2
42retinoic acid45 2410.9CSF3, CTGF, RCVRN, IL6, THPO, PTHLH
43lipid459.8AMPH, SAG, CTGF, RCVRN, IL6, PTHLH
44p003459.8CTGF, THPO, PECAM1
45tyrosine459.7SAG, CSF3, CTGF, AIRE, FGF23, IL6
46calcium45 50 11 2412.5CTGF, SAG, SFRP4, AMPH, PHEX, FGF23

GO Terms for genes affiliated with Paraneoplastic Syndromes

Sources:
16Gene Ontology
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Cellular components related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.5PECAM1, PTHLH, THPO, IL6, FGF23, CTGF

Biological processes related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphate ion homeostasisGO:05506210.3FGF23, SFRP4
2negative regulation of bone mineralizationGO:03050210.2FGF23, MEPE
3negative regulation of neuron deathGO:190121510.2IL6, CSF3
4negative regulation of hormone secretionGO:04688810.2FGF23, IL6
5positive regulation of ERK1 and ERK2 cascadeGO:0703749.9IL6, FGF23, CTGF

Molecular functions related to Paraneoplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.9THPO, IL6, FGF23, CTGF, CSF3

Products for genes affiliated with Paraneoplastic Syndromes

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  • Proteins
  • Lysates
  • Antibodies

Sources for Paraneoplastic Syndromes

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet