Aliases & Classifications for Paraneoplastic Syndromes

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Sources:
42NINDS, 43Novoseek, 60UMLS
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Paraneoplastic Syndromes, Aliases & Descriptions:

Name: Paraneoplastic Syndromes 42 43 60


Summaries for Paraneoplastic Syndromes

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NINDS:42 Paraneoplastic syndromes are a group of rare disorders that are triggered by an abnormal immune system response to a cancerous tumor known as a "neoplasm." Paraneoplastic syndromes are thought to happen when cancer-fighting antibodies or white blood cells (known as T cells) mistakenly attack normal cells in the nervous system. These disorders typically affect middle-aged to older people and are most common in individuals with lung, ovarian, lymphatic, or breast cancer. Neurologic symptoms generally develop over a period of days to weeks and usually occur prior to the tumor being discovered. These symptoms may include difficulty in walking or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo or dizziness. Paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis, myasthenia gravis, cerebellar degeneration, limbic or brainstem encephalitis, neuromyotonia, opsoclonus, and sensory neuropathy.

MalaCards based summary: Paraneoplastic Syndromes is related to hypercalcemia and osteomalacia. An important gene associated with Paraneoplastic Syndromes is FGF23 (fibroblast growth factor 23), and among its related pathways are amb2 Integrin signaling and Activation of cAMP-Dependent PKA. The compounds 25-hydroxyvitamin d and octreotide have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and t cells, and related mouse phenotypes are limbs/digits/tail and reproductive system.

Wikipedia:63 A paraneoplastic syndrome is a syndrome (a set of signs and symptoms) that is the consequence of cancer... more...

Related Diseases for Paraneoplastic Syndromes

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Diseases related to Paraneoplastic Syndromes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1hypercalcemia30.9PTHLH, FGF23
2osteomalacia30.3PTHLH, FGF23, PHEX
3peritonitis30.1IL6, CTGF
4lung cancer10.6
5mccune-albright syndrome, somatic, mosaic10.5FGF23
6renal cell carcinoma10.4
7breast cancer10.4
8hepatocellular carcinoma10.3
9lambert-eaton myasthenic syndrome10.3
10adenocarcinoma10.3
11thymoma10.3
12cerebellar degeneration10.3
13leukemia10.2
14neuroendocrine carcinoma10.2
15neuronitis10.2
16encephalitis10.2
17prostatitis10.2
18oral cancer10.2
19syndrome of inappropriate antidiuretic hormone10.2
20anemia, sideroblastic, pyridoxine-refractory, autosomal recessive10.2FGF23, AIRE
21primary hyperparathyroidism10.2FGF23, PTHLH
22secondary hyperparathyroidism of renal origin10.2FGF23, PTHLH
23hypophosphatemic rickets, autosomal dominant10.2FGF23, PHEX
24synovitis10.2IL6
25hypophosphatemic rickets, x-linked dominant10.2FGF23, PHEX
26prostate cancer10.2
27pheochromocytoma10.2
28myasthenia gravis10.2
29thrombocytosis10.2
30acanthosis nigricans10.2
31small cell carcinoma10.2
32adult-onset still's disease10.2
33dermatomyositis10.2
34fasciitis10.2
35ganglioneuroblastoma10.2
36laryngitis10.2
37melanoma10.2
38pancreatitis10.2
39sarcoma10.2
40thyroiditis10.2
41limbic encephalitis10.2
42oncogenic osteomalacia10.2
43polymyositis10.2
44subacute cerebellar degeneration10.2
45metaphyseal dysplasia10.2AIRE, PTHLH
46rickets10.1PHEX, FGF23
47infertility10.1DAZL, FGF23
48myelodysplastic syndrome10.1
49b-cell lymphomas10.1
50relapsing polychondritis10.1

Graphical network of the top 20 diseases related to Paraneoplastic Syndromes:



Diseases related to paraneoplastic syndromes

Symptoms for Paraneoplastic Syndromes

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Drugs & Therapeutics for Paraneoplastic Syndromes

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Drug clinical trials:

Search ClinicalTrials for Paraneoplastic Syndromes

Search NIH Clinical Center for Paraneoplastic Syndromes

Genetic Tests for Paraneoplastic Syndromes

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Anatomical Context for Paraneoplastic Syndromes

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MalaCards organs/tissues related to Paraneoplastic Syndromes:

31
Lung, Breast, T cells, Ovary, Colon, Prostate, Thyroid, Brain, Kidney, Liver, Testes, Myeloid, B cells, Spinal cord

Animal Models for Paraneoplastic Syndromes or affiliated genes

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Publications for Paraneoplastic Syndromes

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Articles related to Paraneoplastic Syndromes:

(show top 50)    (show all 373)
idTitleAuthorsYear
1
Myopathy as paraneoplastic syndrome of colon malignancy in an elderly patient. (23739910)
2013
2
Update on clinical and mechanistic aspects of paraneoplastic syndromes. (24052434)
2013
3
Lung cancer-induced paraneoplastic syndromes. (21577115)
2011
4
Unusual paraneoplastic syndromes of breast carcinoma: a combination of cerebellar degeneration and Lambert-Eaton Myasthenic Syndrome. (19005633)
2011
5
Paraneoplastic syndrome of inappropriate antidiuretic hormone mimicking limbic encephalitis. (22159058)
2011
6
Paraneoplastic syndromes related to lung cancer. (20529797)
2010
7
Oral cancer-associated paraneoplastic syndromes. (21180290)
2010
8
Neuromuscular paraneoplastic syndromes: the Lambert-Eaton myasthenic syndrome. (20836646)
2010
9
Review of paraneoplastic syndromes associated with oropharyngeal squamous cell carcinoma. (21731261)
2010
10
POEMS syndrome - a unique presentation of a rare paraneoplastic syndrome. (22798312)
2010
11
Paraneoplastic syndromes in patients with nasopharyngeal cancer. (19111998)
2009
12
Opsoclonus-myoclonus with multiple paraneoplastic syndromes and VGCC antibodies. (19650369)
2009
13
Acquired hypertrichosis lanuginosa: a rare cutaneous paraneoplastic syndrome. (17443005)
2007
14
Paraneoplastic syndromes affecting the nervous system. (16769417)
2006
15
Diagnosis and current treatment of neurological paraneoplastic syndromes. (17134967)
2006
16
Exacerbation of paraneoplastic syndrome of inappropriate antidiuretic hormone by parenteral nutrition in a patient affected by a large-cell neuroendocrine pancreatic cancer. (17085261)
2006
17
Parathyroid adenoma presenting as paraneoplastic syndrome secondary to renal cell carcinoma. (16048706)
2005
18
Keeping "Trk" of paraneoplastic syndromes. (16216932)
2005
19
Paraneoplastic syndromes and the nervous system. (16092599)
2005
20
Paraneoplastic syndromes associated with visual loss. (14615650)
2003
21
Some unusual paraneoplastic syndromes. Case 3. Metastatic pulmonary calcification causing hypoxemia in male breast cancer. (12829686)
2003
22
Amphiphysin paraneoplastic syndrome: a delayed diagnosis of breast carcinoma. (12846868)
2003
23
Some unusual paraneoplastic syndromes. Case 4. Paraneoplastic nephrotic syndrome in a patient with lung cancer. (12829687)
2003
24
Paraneoplastic syndromes associated with bronchogenic carcinoma. (11901915)
2002
25
New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes. (11179499)
2001
26
Paraneoplastic syndrome in the course of lung adenocarcinoma: morphological picture and immunohistochemical analysis of the inflammatory infiltrates and PECAM-1 expression. (11057031)
2000
27
Paraneoplastic syndromes of the nervous system. (10834398)
2000
28
Serum interleukin-6 levels in metastatic renal cell carcinoma before treatment with interleukin-2 correlates with paraneoplastic syndromes but not patient survival. (9474133)
1998
29
Mucocutaneous paraneoplastic syndromes (MCPS). A clinical-pathologic review. (10089068)
1998
30
Central neurological paraneoplastic syndromes. Part 1. Clinical features, pathophysiology and immunopharmacology. (15010705)
1998
31
Paraneoplastic syndromes. (9368783)
1997
32
Paraneoplastic syndromes associated with small cell lung cancer. (9001756)
1997
33
Oculomucocutaneous changes as paraneoplastic syndromes. (8803581)
1996
34
The immunobiology and clinical features of paraneoplastic syndromes. (8845924)
1995
35
Serum biological markers and paraneoplastic syndromes in Wilms tumor. (8383282)
1993
36
Mechanisms of paraneoplastic syndromes of colon-26: involvement of interleukin 6 in hypercalcemia. (8142602)
1993
37
Paraneoplastic syndromes: fads and facts (1) and neurological manifestations of malignant diseases (2) (1452572)
1992
38
Paraneoplastic syndromes. (1620362)
1992
39
Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice. (1999505)
1991
40
Neurological paraneoplastic syndromes. (3284610)
1988
41
Antineuronal autoantibodies in neurologic paraneoplastic syndromes. (3207275)
1988
42
Autoantibodies in paraneoplastic syndromes associated with small-cell lung cancer. (2842702)
1988
43
Paraneoplastic syndromes, tumor markers, and other unusual features of malignant melanoma. (2869074)
1986
44
Paraneoplastic syndromes of the nervous system. (2992171)
1985
45
Paraneoplastic syndromes: introduction. (6755479)
1982
46
Paraneoplastic syndromes of the dog. (117002)
1979
47
Paraneoplastic syndromes associated with gastrointestinal cancer. (1022379)
1976
48
Paraneoplastic syndromes in children? (1107100)
1975
49
The paraneoplastic syndromes associated with carcinoma of the thyroid gland. (4362924)
1974
50
Paraneoplastic syndromes. A clinically relevant concept in cancer. (4354413)
1973

Variations for Paraneoplastic Syndromes

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Expression for genes affiliated with Paraneoplastic Syndromes

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Search GEO for disease gene expression data for Paraneoplastic Syndromes.

Pathways for genes affiliated with Paraneoplastic Syndromes

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Pathways related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2CTGF, IL6
2
Show member pathways
8.8IL6, CTGF, FGF23
3
Show member pathways
8.8IL6, CTGF, FGF23
4
Show member pathways
8.8IL6, CTGF, FGF23
5
Show member pathways
8.8IL6, CTGF, FGF23
6
Show member pathways
8.8FGF23, CTGF, IL6
7
Show member pathways
8.8FGF23, CTGF, IL6
8
Show member pathways
8.8FGF23, CTGF, IL6
9
Show member pathways
8.8FGF23, CTGF, IL6
10
Show member pathways
8.8FGF23, CTGF, IL6
11
Show member pathways
8.8FGF23, CTGF, IL6
12
Show member pathways
8.8FGF23, CTGF, IL6

Compounds for genes affiliated with Paraneoplastic Syndromes

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Compounds related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

(show all 40)
idCompoundScoreTop Affiliating Genes
125-hydroxyvitamin d4310.0FGF23, PTHLH
2octreotide43 59 28 1212.9FGF23, PTHLH
3hydroxyproline43 24 1211.9PTHLH, CTGF
4colchicine43 59 2 28 1213.8PTHLH, CTGF
5bleomycin43 1210.8PTHLH, CTGF
6nocodazole43 1210.7CTGF, PTHLH
7lovastatin43 49 59 28 1213.7CTGF, PTHLH
8hydroxyapatite439.5PTHLH, CTGF, FGF23
915-deoxy-delta-12,14-prostaglandin j2439.5CTGF, IL6
10pamidronate43 49 1211.5IL6, PTHLH
11clodronate43 49 1211.5IL6, PTHLH
12zoledronic acid439.5IL6, PTHLH
13pioglitazone28 43 49 1212.5CTGF, IL6
14heparin43 28 24 1212.5PTHLH, CTGF, FGF23
15pravastatin43 49 28 24 1213.5IL6, CTGF
16aprotinin43 1210.4IL6, PTHLH
17sp 60012543 5910.4IL6, CTGF
18phosphorus439.4PTHLH, PHEX, FGF23
191,25 dihydroxy vitamin d3439.4PTHLH, PHEX, FGF23
20prednisolone43 28 1211.3IL6, PTHLH
21hydrocortisone43 2 59 1212.2PTHLH, IL6
22nifedipine43 28 49 1212.2CTGF, PTHLH
23rosiglitazone28 43 49 24 1213.1IL6, PTHLH
24tgf beta1439.1CTGF, IL6, PTHLH
25simvastatin43 49 59 28 24 1214.1PTHLH, IL6, CTGF
26prostaglandin439.1PTHLH, IL6, CTGF
27sb 20358043 5910.1AIRE, IL6, CTGF
28pge2439.0PTHLH, IL6, CTGF
29lactate439.0CTGF, IL6, PTHLH
30troglitazone43 28 59 1212.0PTHLH, IL6
31thymidine43 2410.0CTGF, IL6, PTHLH
32cycloheximide439.0PTHLH, IL6, CTGF
33serine438.9FGF23, CTGF, PTHLH, AIRE
34dexamethasone43 49 28 1211.9CTGF, IL6, PTHLH
35vegf438.7CTGF, IL6, PTHLH
36creatinine438.7FGF23, CTGF, IL6, PTHLH
37nitric oxide43 24 1210.7CTGF, IL6, PTHLH
38calcitriol43 59 24 1211.6FGF23, PHEX, IL6, PTHLH
39vitamin d438.6FGF23, PHEX, IL6, PTHLH
40tyrosine438.2FGF23, CTGF, IL6, PTHLH, AIRE

GO Terms for genes affiliated with Paraneoplastic Syndromes

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Cellular components related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:00057948.9CTGF, PHEX, PTHLH
2extracellular spaceGO:00056158.2FGF23, CTGF, IL6, PTHLH
3extracellular regionGO:00055768.0PTHLH, IL6, CTGF, FGF23

Biological processes related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hormone secretionGO:00468889.4FGF23, IL6
2skeletal system developmentGO:00015019.3PHEX, PTHLH
3response to amino acidGO:00432009.3CTGF, IL6
4epidermis developmentGO:00085449.2CTGF, PTHLH
5humoral immune responseGO:00069599.1IL6, AIRE
6positive regulation of ERK1 and ERK2 cascadeGO:00703749.0FGF23, CTGF, IL6
7positive regulation of cell proliferationGO:00082848.7PTHLH, IL6, CTGF
8positive regulation of transcription, DNA-templatedGO:00458938.7AIRE, IL6, FGF23

Molecular functions related to Paraneoplastic Syndromes according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080838.8FGF23, CTGF, IL6

Products for genes affiliated with Paraneoplastic Syndromes

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Sources for Paraneoplastic Syndromes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet