MCID: PRN009
MIFTS: 55

Paranoid Schizophrenia malady

Mental diseases category
Download this MalaCard

Summaries for Paranoid Schizophrenia

About this section


Fully expand this MalaCard
Disease Ontology:8 A schizophrenia that involves delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening.

MalaCards based summary: Paranoid Schizophrenia, also known as chronic paranoid schizophrenia, is related to schizophrenia and obsessive-compulsive disorder. An important gene associated with Paranoid Schizophrenia is COMT (catechol-O-methyltransferase), and among its related pathways are Tyrosine metabolism p.1 dopamine and Phenylalanine metabolism. The drug chlorprothixene and the compounds 3-methoxytyramine and dopeg have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and brain, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Wikipedia:65 Paranoid schizophrenia, also called schizophrenia, paranoid type is a sub-type of schizophrenia as... more...

Aliases & Classifications for Paranoid Schizophrenia

About this section
Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 27ICD9CM, 57SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
See all sources

Paranoid Schizophrenia, Aliases & Descriptions:

Name: Paranoid Schizophrenia 8 44 62
Chronic Paranoid Schizophrenia 8 62
Paraphrenic Schizophrenia 8 62
Paranoid Type Schizophrenia Subchronic State 8
 
Schizophrenia, Paranoid Type 62
Paranoid Type Schizophrenia 8
Paraphrenia - Late 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Related Diseases for Paranoid Schizophrenia

About this section

Diseases related to Paranoid Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.7GLS, MAOA, COMT, CCKAR
2obsessive-compulsive disorder30.6COMT, MAOA
3psychotic disorder30.5MAOA, COMT
4mood disorder30.4MAOA, COMT
5parkinson's disease30.4MAOA, COMT
6dementia30.3COMT, MAOA, GLS
7mental retardation30.2COMT, MAOA, ALDH5A1
8generalized anxiety disorder10.4MAOA
9antisocial personality disorder10.4MAOA
10delusional disorder10.4
11blindness10.4
12klinefelter's syndrome10.3
13personality disorder10.3
14social phobia10.2MAOA, COMT
15conduct disorder10.2COMT, MAOA
16bulimia nervosa10.2MAOA, COMT
17gilles de la tourette syndrome10.2MAOA, COMT
18anxiety disorder10.2MAOA, COMT
19attention deficit hyperactivity disorder10.2COMT, MAOA
20hepatic encephalopathy10.2GLS, MAOA
21anorexia nervosa10.2COMT, MAOA
22alcohol abuse10.2
23brain injury10.2
24major depressive disorder10.2
25traumatic brain injury10.2
26ulcerative colitis10.2
27post-traumatic stress disorder10.2
28neuroleptic malignant syndrome10.2
29capgras syndrome10.2
30priapism10.2
31peripartum cardiomyopathy10.2
32vascular dementia10.2
33graves' disease10.2
34alcohol dependence10.2
35narcolepsy10.2
36alexithymia10.2
37mutism10.2
38kallmann syndrome10.2
39autism spectrum disorder10.2
40colitis10.2
41esophagitis10.2
42factitious disorder10.2
43influenza10.2
44scleroderma10.2
45thyroiditis10.2
46nephritis10.2
47eating disorder10.1COMT, CCKAR
48migraine10.1MAOA, COMT
49bipolar disorder10.1MAOA, COMT
50pancreatic cancer10.0MAOA, CCKAR

Graphical network of the top 20 diseases related to Paranoid Schizophrenia:



Diseases related to paranoid schizophrenia

Symptoms for Paranoid Schizophrenia

About this section

Drugs & Therapeutics for Paranoid Schizophrenia

About this section

Drug clinical trials:

Search ClinicalTrials for Paranoid Schizophrenia

Search NIH Clinical Center for Paranoid Schizophrenia

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Paranoid Schizophrenia

About this section

Anatomical Context for Paranoid Schizophrenia

About this section

MalaCards organs/tissues related to Paranoid Schizophrenia:

32
Testes, Eye, Brain, Pituitary, Cortex, Thyroid, Prefrontal cortex, Amygdala

Animal Models for Paranoid Schizophrenia or affiliated genes

About this section

MGI Mouse Phenotypes related to Paranoid Schizophrenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.8FADS2, CCKAR, COMT, ALDH5A1
2MP:00053767.6ALDH5A1, MAOA, COMT, CCKAR, FADS2
3MP:00053867.0GLS, ALDH5A1, MAOA, COMT, CCKAR, FADS2

Publications for Paranoid Schizophrenia

About this section

Articles related to Paranoid Schizophrenia:

(show top 50)    (show all 272)
idTitleAuthorsYear
1
TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese. (24668623)
2014
2
Alcohol abuse as the strongest risk factor for violent offending in patients with paranoid schizophrenia. (24778102)
2014
3
Lack of association of IL-6 (-174 G>C) and TNF-I+ (-238 G>A) variants with paranoid schizophrenia in Indian Bengalee population. (23265967)
2013
4
Abnormal auditory sensory gating-out in first-episode and never-medicated paranoid schizophrenia patients: an fMRI study. (23820976)
2013
5
BDNF val66met polymorphism is associated with age at onset and intensity of symptoms of paranoid schizophrenia in a Polish population. (23487199)
2013
6
Kallmann syndrome and paranoid schizophrenia: a rare combination. (23329708)
2013
7
Capgras delusion in paranoid schizophrenia complicated by vascular dementia. (23037670)
2012
8
Positron emission tomography experience with 2-[A^a8,F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[A^a8,F]FA) in the living human brain of smokers with paranoid schizophrenia. (22169936)
2012
9
Association study of interferon gamma (IFN-I^) +874T/A gene polymorphism in patients with paranoid schizophrenia. (20821074)
2011
10
Different aspects of theory of mind in paranoid schizophrenia: evidence from a video-based assessment. (20947175)
2011
11
Functional polymorphism in the interleukin-6 and interleukin-10 genes in patients with paranoid schizophrenia--a case-control study. (20393813)
2010
12
Olanzapine-induced neuroleptic malignant syndrome in a patient with paranoid schizophrenia. (19067992)
2009
13
The influence of emotion clarity on emotional prosody identification in paranoid schizophrenia. (19000339)
2009
14
Neuropsychological relationships in paranoid schizophrenia with and without delusional misidentification syndromes. A comparative study. (18539375)
2008
15
EEG phase synchronization in patients with paranoid schizophrenia. (18835328)
2008
16
Prolactin and estradiol serum levels in unmedicated male paranoid schizophrenia patients. (17110010)
2007
17
Functional disintegration in paranoid schizophrenia using resting-state fMRI. (17628434)
2007
18
Aberrantly flattened responsivity to emotional pictures in paranoid schizophrenia. (16884781)
2006
19
Genetic associations between delusional disorder and paranoid schizophrenia: A novel etiologic approach. (16786814)
2006
20
A patient's journey: living with paranoid schizophrenia. (16990323)
2006
21
Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. (14992974)
2004
22
Factor structure of paranoid schizophrenia: a prospective study. (12845284)
2003
23
Anterior cingulate metabolism correlates with stroop errors in paranoid schizophrenia patients. (11377927)
2001
24
Insight in paranoid schizophrenia--its relationship to psychopathology and premorbid adjustment. (9777276)
1998
25
Sex-specific expression of Heschl's gyrus functional and structural abnormalities in paranoid schizophrenia. (9396942)
1997
26
Conjugate lateral eye movements during exacerbation of paranoid schizophrenia and the acute episode of major depression. (9129787)
1997
27
Maintenance ECT for treatment of therapy-resistant paranoid schizophrenia and Parkinson's disease. (7548464)
1995
28
The Capgras syndrome in paranoid schizophrenia. (1448540)
1992
29
Wisconsin Card Sorting Test deficits in chronic paranoid schizophrenia. Evidence for a relatively discrete subgroup? (1515378)
1992
30
Paranoid schizophrenia: prognosis under DSM-II and DSM-III-R. (2731425)
1989
31
A three-year prospective follow-up of psychopathology and social reintegration in paranoid schizophrenia in relation to age at onset. (3399822)
1988
32
Motor and sighting dominance in schizophrenia and affective disorder. Evidence for right-hand grip strength prominence in paranoid schizophrenia and bipolar illness. (4016461)
1985
33
Is loxapine more effective than chlorpromazine in paranoid schizophrenia? (6388362)
1984
34
Illusory correlations in paranoid and non-paranoid schizophrenia. (6487859)
1984
35
Post-traumatic stress disorder masquerading as paranoid schizophrenia: case report. (6817230)
1982
36
Cross-cultural study of a biochemical abnormality in paranoid schizophrenia. (6948314)
1981
37
Paranoid schizophrenia and platelet MAO activity. (7435694)
1980
38
Possible implication of an inosinetriphosphate metabolic error and glutamic acid decarboxylase in paranoid schizophrenia. (110320)
1979
39
Manic-depressive illness or paranoid schizophrenia? (290045)
1979
40
Split decision: critique of complete audit of paranoid schizophrenia. (103052)
1978
41
Nursing care study. Paranoid schizophrenia: learning to cope with eccentricity. (252023)
1978
42
Iowa 500: the clinical and genetic distinction of hebephrenic and paranoid schizophrenia. (4835424)
1974
43
PARANOID SCHIZOPHRENIA IN A PATIENT WITH KLINEFELTER'S SYNDROME. (14220862)
1964
44
The Rorschach "eyes' hypothesis and paranoid schizophrenia. (13887991)
1962
45
A double-blind trial to investigate the effects of Thorazine (Largactil, chlorpromazine), Compazine (Stemetil, prochlorperazine) and Stelazine (trifluoperazine) in paranoid schizophrenia. (13785665)
1961
46
A short scale for rating paranoid schizophrenia. (13841648)
1959
47
Clinical aspects of paraphrenic (delusional paranoid) schizophrenia]. (13605174)
1958
48
Prognosis in paranoid schizophrenia on the basis of the Rorschach. (13061662)
1953
49
A dynamic factor correlated with the prognosis in paranoid schizophrenia. (14818482)
1951
50
The place of paranoid states in psychiatric classification with special reference to paranoid schizophrenia. (18875667)
1948

Variations for Paranoid Schizophrenia

About this section

Expression for genes affiliated with Paranoid Schizophrenia

About this section
Expression patterns in normal tissues for genes affiliated with Paranoid Schizophrenia

Search GEO for disease gene expression data for Paranoid Schizophrenia.

Pathways for genes affiliated with Paranoid Schizophrenia

About this section

Pathways related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MAOA, COMT
2
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
9.6MAOA, COMT
3
Show member pathways
catecholamine biosynthesis37
9.6MAOA, COMT
49.6MAOA, COMT
59.6MAOA, COMT
6
Show member pathways
9.6MAOA, COMT
7
Show member pathways
citrulline-nitric oxide cycle37
arginine degradation I (arginase pathway)37
proline degradation37
glutamine degradation I37
proline biosynthesis I37
superpathway of citrulline metabolism37
proline biosynthesis II (from arginine)37
citrulline biosynthesis37
arginine degradation VI (arginase 2 pathway)37
Urea cycle and metabolism of amino groups37
asparagine biosynthesis I37
4-hydroxyproline degradation I37
citrulline degradation37
9.5GLS, MAOA
89.4ALDH5A1, GLS
9
Show member pathways
9.1GLS, MAOA, COMT
10
Show member pathways
9.0GLS, ALDH5A1, MAOA
11
Show member pathways
8.6COMT, MAOA, ALDH5A1, GLS
12
Show member pathways
7.7FADS2, COMT, MAOA, ALDH5A1, GLS

Compounds for genes affiliated with Paranoid Schizophrenia

About this section
Sources:
44Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 28IUPHAR
See all sources

Compounds related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
13-methoxytyramine44 2411.0COMT, MAOA
2dopeg4410.0COMT, MAOA
3nialamide44 1111.0MAOA, COMT
4normetanephrine44 2411.0COMT, MAOA
5metanephrine44 2411.0MAOA, COMT
6dopac4410.0MAOA, COMT
7mhpg4410.0MAOA, COMT
8methylphenidate44 50 1112.0MAOA, COMT
9maoa4410.0COMT, MAOA
10homovanillic acid44 2411.0MAOA, COMT
11fluvoxamine44 50 1112.0COMT, MAOA
12tyramine44 28 2412.0COMT, MAOA
13selegiline44 1111.0MAOA, COMT
14paroxetine44 50 28 1113.0MAOA, COMT
15methamphetamine44 50 1111.9COMT, MAOA
166-hydroxydopamine449.9MAOA, COMT
17mptp449.9COMT, MAOA
18levodopa44 1110.9COMT, MAOA
19pyridoxal 5-phosphate449.8COMT, GLS
20Ammonia249.8MAOA, GLS
21amine449.8MAOA, COMT
22benzodiazepines449.8CCKAR, MAOA
23vitamin b6449.8ALDH5A1, GLS
24benzodiazepine449.8CCKAR, MAOA
25catecholamine449.8MAOA, COMT
26succinate449.8ALDH5A1, MAOA
27n-ethylmaleimide44 1110.7GLS, MAOA
28alpha-ketoglutarate449.7GLS, ALDH5A1
29carbon449.6MAOA, COMT
30nad+449.6ALDH5A1, GLS
31morphine44 50 28 1112.5COMT, CCKAR
32choline44 24 1111.5GLS, MAOA, COMT
33nmda44 2810.4COMT, MAOA, GLS
34cocaine44 1110.3CCKAR, COMT
35dopamine44 28 24 1112.3CCKAR, COMT, MAOA
365-hydroxytryptamine449.3MAOA, COMT
37glutamine449.1GLS, ALDH5A1, CCKAR
38Water249.1MAOA, ALDH5A1, GLS
39glutamate449.0COMT, MAOA, ALDH5A1, GLS
40alanine448.8GLS, ALDH5A1, CCKAR
41gaba448.8GLS, ALDH5A1, MAOA, CCKAR

GO Terms for genes affiliated with Paranoid Schizophrenia

About this section

Cellular components related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:0057398.6GLS, ALDH5A1, MAOA, COMT

Biological processes related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:0424209.7COMT, MAOA
2neurotransmitter biosynthetic processGO:0421369.6MAOA, COMT
3xenobiotic metabolic processGO:0068059.6MAOA, COMT
4neurotransmitter catabolic processGO:0421359.3ALDH5A1, MAOA, COMT
5protein homotetramerizationGO:0512899.1GLS, ALDH5A1
6neurotransmitter secretionGO:0072699.1MAOA, ALDH5A1, GLS
7synaptic transmissionGO:0072688.7GLS, ALDH5A1, MAOA, COMT
8small molecule metabolic processGO:0442818.2FADS2, COMT, MAOA, GLS

Products for genes affiliated with Paranoid Schizophrenia

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Paranoid Schizophrenia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet