MCID: PRN009
MIFTS: 59

Paranoid Schizophrenia malady

Neuronal diseases category

Summaries for Paranoid Schizophrenia

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A schizophrenia that involves delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening.

MalaCards: Paranoid Schizophrenia, also known as chronic paranoid schizophrenia, is related to schizophrenia and psychotic disorder. An important gene associated with Paranoid Schizophrenia is COMT (catechol-O-methyltransferase), and among its related pathways are Taurine and hypotaurine metabolism and GABA synthesis. The drug chlorprothixene and the compounds succinic semialdehyde and oleamide have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and brain, and related mouse phenotypes are respiratory system and no phenotypic analysis.

Wikipedia:63 Paranoid schizophrenia, also called schizophrenia, paranoid type is a sub-type of schizophrenia as... more...

Aliases & Classifications for Paranoid Schizophrenia

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

paranoid schizophrenia 8 44 60
chronic paranoid schizophrenia 8 60
paranoid type schizophrenia subchronic state 8
paranoid type schizophrenia 8
paraphrenic schizophrenia 8
paraphrenia - late 8


Related Diseases for Paranoid Schizophrenia

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17GeneCards, 18GeneDecks
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Diseases related to Paranoid Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.9GLS, PAX6, CYP1A2, GLUL, CNR1, MAOA
2psychotic disorder30.4MAOA, CNR1, BDNF, GAD1, COMT
3parkinson's disease30.4COMT, CNR1, MAOA, BDNF, GAD2, DDC
4alcohol dependence30.1MAOA, CNR1
5thyroiditis30.1GAD2, POMC
6narcolepsy30.1TNFRSF1B, COMT
7obsessive-compulsive disorder30.1MAOA, BDNF, COMT
8dementia30.1MAOA, COMT, BDNF, GLS, TNFRSF1B
9graves' disease30.1GAD2, GAD1, DDC
10mood disorder30.1POMC, MAOA, CNR1, BDNF, COMT, GAD1
11bipolar disorder30.1BDNF, GAD1, DDC, COMT, MAOA, CNR1
12delusional disorder10.3
13klinefelter's syndrome10.3
14vascular dementia10.1
15capgras syndrome10.1
16major depressive disorder10.1
17kallmann syndrome10.1
18paranoid personality disorder10.1
19alexithymia10.1
20priapism10.1
21peripartum cardiomyopathy10.1
22post-traumatic stress disorder10.1
23ulcerative colitis10.1
24mutism10.1
25neuroleptic malignant syndrome10.1
26large cell carcinoma10.1
27esophagitis10.1
28factitious disorder10.1
29influenza10.1
30personality disorder10.1
31scleroderma10.1
32squamous cell carcinoma10.1
33fibromyalgia10.0COMT
34substance abuse10.0CNR1
35autoimmune polyendocrine syndrome10.0DDC
36borderline personality disorder10.0MAOA
37galactosemia10.0CYP1A2
38intellectual disability10.0PAX6
39l-2-hydroxyglutaric aciduria10.0GLS2
40hepatitis c10.0CYP1A2
41hypertension10.0POMC
42neuroblastoma10.0BDNF
43lung cancer10.0POMC
44substance dependence10.0COMT, CNR1
45lennox-gastaut syndrome10.0ABAT
46drug dependence10.0MAOA, CNR1
47cocaine dependence10.0POMC
48schizoaffective disorder10.0COMT, BDNF
49encephalitis10.0GAD2, CNR1
50cannabis dependence10.0CNR1

Graphical network of the top 20 diseases related to Paranoid Schizophrenia:



Diseases related to paranoid schizophrenia

Clinical Features for Paranoid Schizophrenia

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Drugs & Therapeutics for Paranoid Schizophrenia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Paranoid Schizophrenia

Drug clinical trials:

Search ClinicalTrials for Paranoid Schizophrenia

Search NIH Clinical Center for Paranoid Schizophrenia

Search CenterWatch for Paranoid Schizophrenia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Paranoid Schizophrenia

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Anatomical Context for Paranoid Schizophrenia

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32MalaCards
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MalaCards organs/tissues related to Paranoid Schizophrenia:

32
Testes, Eye, Brain, Pituitary, Cortex, Thyroid, Prefrontal cortex, Amygdala

Animal Models for Paranoid Schizophrenia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Paranoid Schizophrenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.6BDNF, TNFRSF1B, GAD2, GAD1, GLS, CYP1A2
2MP:00030129.6GAD2, GAD1, POMC, CNR1, CYP1A2, BDNF
3MP:00053679.5COMT, TNFRSF1B, GADD45A, DDC, POMC, PAX6
4MP:00053859.0COMT, TNFRSF1B, GADD45A, DDC, POMC, MAOA
5MP:00053788.9BDNF, GAD2, GAD1, GADD45A, DDC, POMC
6MP:00036318.8COMT, BDNF, TNFRSF1B, GAD2, GAD1, GADD45A
7MP:00053868.8ALDH5A1, COMT, BDNF, TNFRSF1B, GAD2, GAD1
8MP:00107688.7GADD45A, GAD1, GAD2, TNFRSF1B, BDNF, DDC
9MP:00053768.7GADD45A, GAD1, GAD2, TNFRSF1B, BDNF, COMT

Publications for Paranoid Schizophrenia

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50PubMed
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Articles related to Paranoid Schizophrenia:

(show top 50)    (show all 272)
idTitleAuthorsYear
1
BDNF val66met polymorphism is associated with age at onset and intensity of symptoms of paranoid schizophrenia in a Polish population. (23487199)
2013
2
Electroconvulsive Therapy for Long-term Mutism in a Case of Noncatatonic Paranoid Schizophrenia. (24062967)
2013
3
Do patients with paranoid and disorganized schizophrenia respond differently to antipsychotic drugs? (24299424)
2013
4
The interaction of BDNF and NTRK2 gene increases the susceptibility of paranoid schizophrenia. (24069289)
2013
5
Distinct structural alterations independently contributing to working memory deficits and symptomatology in paranoid schizophrenia. (23040316)
2013
6
Relationship between genetic polymorphisms in the HTR1A gene and paranoid schizophrenia in a northern Han Chinese population. (23192369)
2013
7
Functional polymorphism of genes inactivating biogenic amines and cognitive deficits in paranoid schizophrenia]. (23888755)
2013
8
Challenges in managing a mother with a dual diagnosis of peripartum cardiomyopathy and paranoid schizophrenia - a case report. (23742788)
2013
9
History of Religious Delusions and Psychosocial Functioning Among Mexican Patients with Paranoid Schizophrenia. (23674244)
2013
10
Relationship between genetic polymorphisms of 3 SNP loci in 5-HTT gene and paranoid schizophrenia]. (23484320)
2012
11
Antipsychotic treatment of acute paranoid schizophrenia patients with olanzapine results in altered glycosylation of serum glycoproteins. (22594947)
2012
12
Morphological and functional abnormalities of salience network in the early-stage of paranoid schizophrenia. (22910405)
2012
13
A study of theory of mind in paranoid schizophrenia: a theory or many theories? (23162496)
2012
14
Association study of interferon gamma (IFN-I^) +874T/A gene polymorphism in patients with paranoid schizophrenia. (20821074)
2011
15
Different aspects of theory of mind in paranoid schizophrenia: evidence from a video-based assessment. (20947175)
2011
16
Association of the Met-196-Arg variation of human tumor necrosis factor receptor 2 (TNFR2) with paranoid schizophrenia. (20842464)
2011
17
Alexithymia and personality disorder functioning styles in paranoid schizophrenia. (21847004)
2011
18
Assessment of white matter abnormalities in paranoid schizophrenia and bipolar mania patients. (22079662)
2011
19
Polymorphisms of the 5-HT2A receptor gene and clinical response to olanzapine in paranoid schizophrenia. (21912188)
2011
20
Decision making on ambiguous stimuli such as prosody by subjects suffering from paranoid schizophrenia, alcohol dependence, and without psychiatric diagnosis. (21506945)
2011
21
Working memory and multi-tasking in paranoid schizophrenia with and without comorbid substance use disorder. (18412756)
2008
22
Prolactin and estradiol serum levels in unmedicated male paranoid schizophrenia patients. (17110010)
2007
23
Functional disintegration in paranoid schizophrenia using resting-state fMRI. (17628434)
2007
24
Avoidant personality disorder is a separable schizophrenia-spectrum personality disorder even when controlling for the presence of paranoid and schizotypal personality disorders The UCLA family study. (17306508)
2007
25
A patient's journey: living with paranoid schizophrenia. (16990323)
2006
26
Cochlear implantation in severe traumatic brain-injury and paranoid schizophrenia: two case studies. (16220855)
2005
27
Subtelomeric deletion of 18p in an adult with paranoid schizophrenia and mental retardation. (14708108)
2004
28
The human dihydropyrimidinase-related protein 2 gene on chromosome 8p21 is associated with paranoid-type schizophrenia. (12679234)
2003
29
Hemispheric processing deficits in patients with paranoid schizophrenia. (10705587)
2000
30
Is paranoid schizophrenia the most common subtype? Comparison of subtype diagnoses by Japanese and European psychiatrists, using the summaries of the same patients. (10026454)
1999
31
Paranoid schizophrenia--malingering or factitious disorder? (10080579)
1999
32
Interhemispheric EEG coherence in never-medicated patients with paranoid schizophrenia: analysis at rest and during photic stimulation. (9783090)
1998
33
Conjugate lateral eye movements during exacerbation of paranoid schizophrenia and the acute episode of major depression. (9129787)
1997
34
Paranoid schizophrenia with delusions regarding the Internet. (9074309)
1997
35
First person account: paranoid schizophrenia--a sibling's story. (8873305)
1996
36
Quantitative EEG analysis at rest and during photic stimulation in drug-naive patients with first-episode paranoid schizophrenia. (7893770)
1994
37
Early longitudinal course of acute-chronic and paranoid--undifferentiated schizophrenia subtypes and schizophreniform disorder. (1757674)
1991
38
A study of thought disorder in paranoid and non-paranoid schizophrenia. (1754647)
1991
39
CSF phenylacetic acid and hostility in paranoid schizophrenia. (2616681)
1989
40
The need to test hypotheses about paranoid schizophrenia: reply to Clementz and Sweeney. (2757298)
1989
41
Alpha-adrenoceptor function in acute paranoid schizophrenia. (2854277)
1988
42
Sleep-onset REM period in paranoid schizophrenia. (4005342)
1985
43
Loxapine versus chlorpromazine in paranoid schizophrenia: a double-blind study. (6370967)
1984
44
Alcoholic hallucinosis and paranoid schizophrenia-a comparative (clinical and follow up) study. (22058494)
1980
45
Amphetamine psychosis or paranoid schizophrenia? (1130030)
1975
46
Manic-depressive illness and paranoid schizophrenia. A phenomenologic, family history, and treatment-response study. (4441237)
1974
47
LOGICAL THINKING AND PARANOID SCHIZOPHRENIA. (14330442)
1965
48
Paranoid schizophrenia. (13903633)
1962
49
A short scale for rating paranoid schizophrenia. (13841648)
1959
50
Aspects of thematic apperception testing: paranoid schizophrenia. (14804028)
1950

Genetic Variations for Paranoid Schizophrenia

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Expression for genes affiliated with Paranoid Schizophrenia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paranoid Schizophrenia

Search GEO for disease gene expression data for Paranoid Schizophrenia.

Pathways for genes affiliated with Paranoid Schizophrenia

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Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB
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Pathways related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2GAD1, GAD2
210.2GAD1, GAD2
3
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10.2CYP1A2, MAOA
4
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10.2ALDH5A1, ABAT
5
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10.2GLS2, GLS
6
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10.1COMT, DDC, MAOA
710.1GLUL, GAD1, GAD2
8
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10.1ALDH3B1, ALDH3A1
9
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10.1CYP1A2, MAOA, DDC
10
Hide members
10.1CYP1A2, MAOA, DDC
1110.1ABAT, GAD1, GAD2
1210.1ABAT, GAD1, GAD2
13
Hide members
10.1ABAT, GAD1, GAD2
14
Hide members
10.0GLS2, GLS, MAOA
1510.0GLS2, GLUL, GLS
16
Hide members
10.0CYP1A2, ALDH3A1, ALDH5A1
17
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10.0MAOA, DDC, GAD1, GAD2
189.9MAOA, GLS, GLUL, GLS2
19
Tyrosine metabolism p.1 (dopamine)
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9.9COMT, DDC, MAOA, ALDH3A1
209.9DDC, GLS, GLUL, GLS2
219.8DDC, MAOA, ALDH3B1, ALDH3A1
229.8BDNF, DDC, MAOA, YWHAZ
23
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9.8MAOA, CYP1A2, ALDH3B1, ALDH3A1
24
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9.7ALDH3A1, ALDH3B1, MAOA, DDC, COMT
259.7GAD2, GAD1, ABAT, ALDH3B1, ALDH3A1
26
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9.5GAD2, GAD1, MAOA, GLS, GLS2, ABAT
279.5ALDH5A1, GAD2, GAD1, GLS, GLUL, GLS2
28
Hide members
9.3COMT, GAD2, GAD1, MAOA, GLS, GLUL
29
Hide members
9.3COMT, GAD2, GAD1, DDC, MAOA, GLS
30
Hide members
9.1COMT, GAD2, GAD1, DDC, MAOA, CNR1

Compounds for genes affiliated with Paranoid Schizophrenia

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1succinic semialdehyde4410.4GAD1, ABAT, ALDH5A1
2oleamide44 28 2412.4CNR1, DDC, MAOA
3mhpg4410.3DDC, MAOA, BDNF, COMT
4vigabatrin44 28 1112.3ALDH5A1, ABAT, POMC
5maoa4410.3COMT, BDNF, POMC, MAOA
6quinolinic acid44 2411.3BDNF, GAD1, GLUL, GLS
7heroin44 49 1112.3CNR1, POMC, COMT, ABAT
8paroxetine44 49 28 1113.3BDNF, CYP1A2, COMT, MAOA
93,4-dihydroxyphenylacetaldehyde44 2411.2ALDH3B1, ALDH3A1, MAOA
10taurine44 59 2412.2GAD1, GLS, ABAT, GAD2
11selegiline44 1111.2BDNF, DDC, COMT, MAOA, CYP1A2
12vitamin b64410.2ALDH5A1, GAD1, GLS, ABAT, DDC
13desipramine44 49 1112.1BDNF, CNR1, CYP1A2, MAOA
14famotidine44 2 11 2413.1ABAT, GAD1, GAD2, GLS2, GLS
15phenylacetaldehyde44 2411.1ALDH3B1, ALDH3A1, MAOA
16ornithine44 2411.1GAD2, GAD1, ABAT, GLUL, GLS
17catecholamine4410.1MAOA, POMC, DDC, BDNF, COMT
18mptp4410.1COMT, BDNF, GAD1, MAOA, DDC, GAD2
19bromocriptine28 44 1112.1COMT, CYP1A2, POMC, DDC
20fluoxetine49 44 28 1113.1CYP1A2, BDNF, MAOA, CNR1
21alpha-ketoglutarate4410.1ABAT, GLS2, GLUL, GLS, GAD1, ALDH5A1
22l-glutamic acid28 11 2412.0GAD2, GAD1, GLS, GLS2, GLUL, ABAT
235-hydroxytryptamine4410.0CNR1, COMT, MAOA, DDC, POMC
24clozapine44 28 49 1113.0GAD1, CYP1A2, TNFRSF1B, POMC, COMT, BDNF
25cocaine44 1111.0COMT, BDNF, ABAT, CNR1, POMC
26homovanillic acid44 2411.0BDNF, ALDH3B1, ALDH3A1, MAOA, DDC, COMT
27valproic acid44 49 11 2413.0BDNF, GAD1, POMC, CYP1A2, ABAT, ALDH5A1
28Pyridoxal Phosphate1110.0ABAT, GAD2, DDC, GAD1
29nmda44 2811.0GAD1, GLS, CNR1, COMT, BDNF, GAD2
30epinephrine44 11 2411.9POMC, BDNF, COMT, MAOA, DDC, CYP1A2
31pyridoxal 5-phosphate449.9ABAT, GLS, GAD1, POMC, GAD2, COMT
326-hydroxydopamine449.9MAOA, COMT, DDC, BDNF
33diazepam44 49 28 1112.9POMC, BDNF, ABAT, CYP1A2
34norepinephrine44 11 2411.9CNR1, DDC, BDNF, POMC, CYP1A2, GLUL
35levodopa44 1110.8GAD2, ABAT, GAD1, DDC, COMT, MAOA
36choline44 11 2411.8DDC, COMT, BDNF, GLS, MAOA, GAD1
37glutamine449.8ALDH5A1, GAD1, POMC, ABAT, GLS2, GLUL
38dopamine44 28 11 2412.8GAD1, ABAT, CNR1, MAOA, COMT, BDNF
39nicotine44 49 28 1112.8CYP1A2, MAOA, ABAT, CNR1, COMT
40ethanol44 49 11 2412.8GLUL, ABAT, COMT, ALDH3A1, ALDH3B1, CYP1A2
41nadph44 2410.7ABAT, ALDH3A1, GAD1, BDNF, ALDH3B1, CYP1A2
42vanillylmandelic acid44 2410.7COMT, ALDH3A1, ALDH3B1
43aspartate449.7GLUL, ABAT, GAD1, GLS2, CNR1, BDNF
44arginine449.6TNFRSF1B, POMC, GLS, GAD1, GLUL, GLS2
45glucose449.6ABAT, POMC, TNFRSF1B, GAD2, GAD1, DDC
46alanine449.3DDC, ALDH5A1, GAD1, GADD45A, CNR1, GLS
47h2o2449.3TNFRSF1B, BDNF, GAD1, MAOA, GADD45A, POMC
48gaba449.2DDC, ALDH5A1, GLS2, GLUL, GLS, CNR1
49oxygen44 2410.2CYP1A2, GLS2, GLUL, GLS, MAOA, GADD45A
50glutamate449.2PAX6, ABAT, GLS2, GLUL, GLS, CNR1

GO Terms for genes affiliated with Paranoid Schizophrenia

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16Gene Ontology
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Cellular components related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:0612029.9GAD1, GAD2
2mitochondrial matrixGO:0057599.9ALDH5A1, ABAT, GLS2, GLS
3mitochondrionGO:0057399.3ALDH5A1, COMT, GLS, GLUL, GLS2, YWHAZ

Biological processes related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylation to succinateGO:00654010.4GAD1, GAD2
2dopamine catabolic processGO:04242010.3COMT, MAOA
3gamma-aminobutyric acid catabolic processGO:00945010.3ALDH5A1, ABAT
4cellular amino acid biosynthetic processGO:00865210.3GLS, GLUL, GLS2
5neurotransmitter biosynthetic processGO:04213610.3COMT, GAD2, GAD1, MAOA
6neurotransmitter catabolic processGO:04213510.2COMT, MAOA, ABAT, ALDH5A1
7glutamate catabolic processGO:00653810.2GAD1, GLUL
8methylationGO:03225910.2CYP1A2, COMT
9glutamate secretionGO:01404710.2GLS2, GLS, BDNF
10behaviorGO:00761010.2ABAT, GLS, CNR1, MAOA
11response to drugGO:0424939.9COMT, GAD2, GAD1, ABAT, ALDH3A1
12neurotransmitter secretionGO:0072699.8ALDH5A1, GAD2, GAD1, MAOA, GLS, GLS2
13cellular nitrogen compound metabolic processGO:0346419.8GLS2, GLUL, GLS, DDC
14synaptic transmissionGO:0072689.6COMT, GAD2, GAD1, MAOA, GLS, GLUL
15small molecule metabolic processGO:0442819.2COMT, DDC, MAOA, GLS, GLUL, GLS2

Molecular functions related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylase activityGO:00435110.2GLUL, GAD1, GAD2
2glutamate bindingGO:01659510.2GLUL, GAD1, GAD2
3aldehyde dehydrogenase [NAD(P)+] activityGO:00403010.1ALDH3A1, ALDH3B1
4glutaminase activityGO:00435910.1GLS2, GLS
5pyridoxal phosphate bindingGO:0301709.9GAD2, GAD1, DDC, ABAT
63-chloroallyl aldehyde dehydrogenase activityGO:0040289.8ALDH3A1, ALDH3B1

Products for genes affiliated with Paranoid Schizophrenia

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Sources for Paranoid Schizophrenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet