MCID: PRN009
MIFTS: 57

Paranoid Schizophrenia malady

Neuronal category

Summaries for Paranoid Schizophrenia

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A schizophrenia that involves delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening.

MalaCards: Paranoid Schizophrenia, also known as chronic paranoid schizophrenia, is related to parkinson's disease and alcohol dependence. An important gene associated with Paranoid Schizophrenia is COMT (catechol-O-methyltransferase), and among its related pathways are Taurine and hypotaurine metabolism and GABA synthesis. The drug chlorprothixene and the compounds succinic semialdehyde and oleamide have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and thyroid, and related mouse phenotypes are respiratory system and no phenotypic analysis.

Wikipedia:64 Paranoid schizophrenia, also called schizophrenia, paranoid type is a sub-type of schizophrenia as... more...

Aliases & Classifications for Paranoid Schizophrenia

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

paranoid schizophrenia 8 45 61
chronic paranoid schizophrenia 8 61
paranoid type schizophrenia subchronic state 8
paranoid type schizophrenia 8
paraphrenic schizophrenia 8
paraphrenia - late 8


Related Diseases for Paranoid Schizophrenia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Paranoid Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease30.4COMT, BDNF, GAD2, DDC, MAOA, CNR1
2alcohol dependence30.2CNR1, MAOA
3narcolepsy30.2TNFRSF1B, COMT
4obsessive-compulsive disorder30.2COMT, BDNF, MAOA
5mental retardation30.2COMT, BDNF, MAOA, PAX6, ALDH5A1
6graves' disease30.2GAD2, GAD1, DDC
7bipolar disorder30.2COMT, BDNF, GAD2, GAD1, DDC, MAOA
8klinefelter's syndrome10.3
9n syndrome10.3
10vascular dementia10.1
11capgras syndrome10.1
12major depressive disorder10.1
13kallmann syndrome10.1
14paranoid personality disorder10.1
15alexithymia10.1
16priapism10.1
17peripartum cardiomyopathy10.1
18post-traumatic stress disorder10.1
19ulcerative colitis10.1
20mutism10.1
21neuroleptic malignant syndrome10.1
22bipolar i disorder10.1
23large cell carcinoma10.1
24squamous cell carcinoma10.1
25brain injury10.1
26traumatic brain injury10.1
27early-onset schizophrenia10.1
28fibromyalgia10.0COMT
29substance abuse10.0CNR1
30autoimmune polyendocrine syndrome10.0DDC
31borderline personality disorder10.0MAOA
32galactosemia10.0CYP1A2
33intellectual disability10.0PAX6
34l-2-hydroxyglutaric aciduria10.0GLS2
35hepatitis c10.0CYP1A2
36hypertension10.0POMC
37neuroblastoma10.0BDNF
38lung cancer10.0POMC
39substance dependence10.0COMT, CNR1
40lennox-gastaut syndrome10.0ABAT
41drug dependence10.0CNR1, MAOA
42cocaine dependence10.0POMC
43schizoaffective disorder10.0BDNF, COMT
44encephalitis10.0CNR1, GAD2
45conduct disorder10.0COMT, MAOA
46social phobia10.0MAOA, COMT
47cannabis dependence10.0CNR1
48rett syndrome10.0BDNF
49migraine10.0COMT, MAOA, CNR1
50wagr syndrome10.0BDNF, PAX6

Graphical network of the top 20 diseases related to Paranoid Schizophrenia:



Diseases related to paranoid schizophrenia

Clinical Features for Paranoid Schizophrenia

Drugs & Therapeutics for Paranoid Schizophrenia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Paranoid Schizophrenia

Drug clinical trials:

Search ClinicalTrials for Paranoid Schizophrenia

Search NIH Clinical Center for Paranoid Schizophrenia

Search CenterWatch for Paranoid Schizophrenia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Paranoid Schizophrenia

Anatomical Context for Paranoid Schizophrenia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Paranoid Schizophrenia:

33
Brain, Cortex, Thyroid, Prefrontal cortex, Cingulate cortex, Amygdala, Adrenal cortex, Pituitary

Animal Models for Paranoid Schizophrenia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Paranoid Schizophrenia

Sources:
51PubMed
See all sources

Articles related to Paranoid Schizophrenia:

(show top 50)    (show all 273)
idTitleAuthorsYear
1
Are there differential deficits in facial emotion recognition between paranoid and non-paranoid schizophrenia? A signal detection analysis. (23598059)
2013
2
Zotepine-induced convulsive seizures in a chronic case of treatment resistant paranoid schizophrenia. (23543675)
2013
3
Positron emission tomography experience with 2-[A^a8,F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[A^a8,F]FA) in the living human brain of smokers with paranoid schizophrenia. (22169936)
2012
4
Detection of visual events along the apparent motion trace in patients with paranoid schizophrenia. (22546415)
2012
5
Right lateralized white matter abnormalities in first-episode, drug-naive paranoid schizophrenia. (23022507)
2012
6
Striatal mitochondria in subjects with chronic undifferentiated vs. chronic paranoid schizophrenia. (21905126)
2012
7
Processing environmental stimuli in paranoid schizophrenia: recognizing facial emotions and performing executive functions. (23228840)
2012
8
Intermetamorphosis syndrome in a patient with paranoid schizophrenia. (23359896)
2012
9
Subjective emotional over-arousal to neutral social scenes in paranoid schizophrenia. (21792533)
2012
10
Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese population. (22162429)
2012
11
Dose dependent, new onset QTc prolongation in a patient with paranoid schizophrenia receiving Clozapine. (23051123)
2011
12
Sensitization, epileptic-like symptoms and local synchronization in patients with paranoid schizophrenia. (19878702)
2010
13
Dissociative symptoms and interregional EEG cross-correlations in paranoid schizophrenia. (20381169)
2010
14
Neuropsychological relationships in paranoid schizophrenia with and without delusional misidentification syndromes. A comparative study. (18539375)
2008
15
EEG phase synchronization in patients with paranoid schizophrenia. (18835328)
2008
16
Hypothesis: grandiosity and guilt cause paranoia; paranoid schizophrenia is a psychotic mood disorder; a review. (18056109)
2008
17
A case of paranoid schizophrenia complicated by scleroderma with associated esophageal dysmotility. (18360200)
2008
18
Aripiprazole worsening positive symptoms and memantine reducing negative symptoms in a patient with paranoid schizophrenia. (17435943)
2007
19
Genetic associations between delusional disorder and paranoid schizophrenia: A novel etiologic approach. (16786814)
2006
20
Male patients with paranoid schizophrenia have greater ACTH and cortisol secretion in response to metoclopramide-induced AVP release. (15721055)
2005
21
No association between polymorphisms in three genes of cytochrome p450 family and paranoid schizophrenia in northern Chinese Han population. (15363478)
2004
22
Ego functions in relation to stressful life events and indices of psychopathology in paranoid schizophrenia. (15762408)
2004
23
Changes in the lipid phase of erythrocyte membranes in patients with paranoid schizophrenia. (12170315)
2002
24
Jerusalem syndrome or paranoid schizophrenia? (11058200)
2000
25
Functional PAX-6 gene-linked polymorphic region: potential association with paranoid schizophrenia. (10376119)
1999
26
The quality of life of patients with paranoid schizophrenia in London and Berlin. (9257520)
1997
27
Discussion of Bogerts' temporolimbic system theory of paranoid schizophrenia. (9327519)
1997
28
Interpersonal relatedness and paranoid schizophrenia. (8678178)
1996
29
Paranoid schizophrenia may be caused by dopamine hyperactivity of CA1 hippocampus. (1349833)
1992
30
Paranoid schizophrenia in adolescence. (1894588)
1991
31
Plasma dopamine-beta-hydroxylase in familial and sporadic paranoid schizophrenia. (2340326)
1990
32
Zotepine vs. haloperidol in paranoid schizophrenia: a double-blind trial. (2570438)
1989
33
Motor and sighting dominance in schizophrenia and affective disorder. Evidence for right-hand grip strength prominence in paranoid schizophrenia and bipolar illness. (4016461)
1985
34
Is loxapine more effective than chlorpromazine in paranoid schizophrenia? (6388362)
1984
35
Illusory correlations in paranoid and non-paranoid schizophrenia. (6487859)
1984
36
A search for association of HLA antigens with paranoid schizophrenia. A9 appears as a possible marker. (6579723)
1983
37
Reduced serum dopamine-beta-hydroxylase activity in paranoid schizophrenia. (6126229)
1982
38
Cannibalism and vampirism in paranoid schizophrenia. (7240115)
1981
39
Information processing dysfunction in paranoid schizophrenia: a two-factor deficit. (7258380)
1981
40
Possible implication of an inosinetriphosphate metabolic error and glutamic acid decarboxylase in paranoid schizophrenia. (110320)
1979
41
Paranoid schizophrenia in a 47, XYY male. (869036)
1977
42
Criteria for subtyping poor prognosis schizophrenia: a numerical model for differentiating paranoid from non-paranoid schizophrenia. (4617768)
1974
43
Nursing care study: paranoid schizophrenia. (4494706)
1974
44
NONSPECIFICITY OF DIAGNOSIS OF PARANOID SCHIZOPHRENIA. (14237618)
1964
45
Homosexuality and paranoid schizophrenia: a survey of 150 cases and controls. (14409564)
1960
46
Trifluoperazine dihydrochloride (stelazine) in paranoid schizophrenia. (13629044)
1959
47
Paranoid schizophrenia in a mongoloid defective: some theoretical considerations derived from an unusual case. (13665305)
1959
48
Psychosexual identification in paranoid schizophrenia. (14354715)
1955
49
Distortion in paranoid schizophrenia. (13034969)
1953
50
The place of paranoid states in psychiatric classification with special reference to paranoid schizophrenia. (18875667)
1948

Genetic Variations for Paranoid Schizophrenia

Expression for genes affiliated with Paranoid Schizophrenia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Paranoid Schizophrenia

Search GEO for disease gene expression data for Paranoid Schizophrenia.

Pathways for genes affiliated with Paranoid Schizophrenia

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2GAD1, GAD2
210.2GAD1, GAD2
3
Hide members
10.2CYP1A2, MAOA
4
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10.2ALDH5A1, ABAT
5
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10.2GLS2, GLS
6
Hide members
10.1COMT, DDC, MAOA
710.1GLUL, GAD1, GAD2
8
Hide members
10.1ALDH3B1, ALDH3A1
9
Hide members
10.1CYP1A2, MAOA, DDC
10
Hide members
10.1CYP1A2, MAOA, DDC
1110.1ABAT, GAD1, GAD2
1210.1ABAT, GAD1, GAD2
13
Hide members
10.1ABAT, GAD1, GAD2
14
Hide members
10.0GLS2, GLS, MAOA
1510.0GLS2, GLUL, GLS
16
Hide members
10.0CYP1A2, ALDH3A1, ALDH5A1
17
Hide members
10.0MAOA, DDC, GAD1, GAD2
189.9MAOA, GLS, GLUL, GLS2
19
Tyrosine metabolism p.1 (dopamine)
Hide members
9.9COMT, DDC, MAOA, ALDH3A1
209.9DDC, GLS, GLUL, GLS2
219.8DDC, MAOA, ALDH3B1, ALDH3A1
229.8BDNF, DDC, MAOA, YWHAZ
23
Hide members
9.8MAOA, CYP1A2, ALDH3B1, ALDH3A1
24
Hide members
9.7ALDH3A1, ALDH3B1, MAOA, DDC, COMT
259.7GAD2, GAD1, ABAT, ALDH3B1, ALDH3A1
26
Hide members
9.5GAD2, GAD1, MAOA, GLS, GLS2, ABAT
279.5ALDH5A1, GAD2, GAD1, GLS, GLUL, GLS2
28
Hide members
9.3COMT, GAD2, GAD1, MAOA, GLS, GLUL
29
Hide members
9.3COMT, GAD2, GAD1, DDC, MAOA, GLS
30
Hide members
9.1COMT, GAD2, GAD1, DDC, MAOA, CNR1

Compounds for genes affiliated with Paranoid Schizophrenia

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1succinic semialdehyde4510.4GAD1, ABAT, ALDH5A1
2oleamide45 29 2412.4CNR1, DDC, MAOA
3mhpg4510.3DDC, MAOA, BDNF, COMT
4vigabatrin45 29 1112.3ALDH5A1, ABAT, POMC
5maoa4510.3COMT, BDNF, POMC, MAOA
6quinolinic acid45 2411.3BDNF, GAD1, GLUL, GLS
7heroin45 50 1112.3CNR1, POMC, COMT, ABAT
8paroxetine45 50 29 1113.3BDNF, CYP1A2, COMT, MAOA
93,4-dihydroxyphenylacetaldehyde45 2411.2ALDH3B1, ALDH3A1, MAOA
10taurine45 60 2412.2GAD1, GLS, ABAT, GAD2
11selegiline45 1111.2BDNF, DDC, COMT, MAOA, CYP1A2
12vitamin b64510.2ALDH5A1, GAD1, GLS, ABAT, DDC
13desipramine45 50 1112.1BDNF, CNR1, CYP1A2, MAOA
14famotidine45 2 11 2413.1ABAT, GAD1, GAD2, GLS2, GLS
15phenylacetaldehyde45 2411.1ALDH3B1, ALDH3A1, MAOA
16ornithine45 2411.1GAD2, GAD1, ABAT, GLUL, GLS
17catecholamine4510.1MAOA, POMC, DDC, BDNF, COMT
18mptp4510.1COMT, BDNF, GAD1, MAOA, DDC, GAD2
19bromocriptine29 45 1112.1COMT, CYP1A2, POMC, DDC
20fluoxetine50 45 29 1113.1CYP1A2, BDNF, MAOA, CNR1
21alpha-ketoglutarate4510.1ABAT, GLS2, GLUL, GLS, GAD1, ALDH5A1
22l-glutamic acid29 11 2412.0GAD2, GAD1, GLS, GLS2, GLUL, ABAT
235-hydroxytryptamine4510.0CNR1, COMT, MAOA, DDC, POMC
24clozapine45 29 50 1113.0GAD1, CYP1A2, TNFRSF1B, POMC, COMT, BDNF
25cocaine45 1111.0COMT, BDNF, ABAT, CNR1, POMC
26homovanillic acid45 2411.0BDNF, ALDH3B1, ALDH3A1, MAOA, DDC, COMT
27valproic acid45 50 11 2413.0BDNF, GAD1, POMC, CYP1A2, ABAT, ALDH5A1
28Pyridoxal Phosphate1110.0ABAT, GAD2, DDC, GAD1
29nmda45 2911.0GAD1, GLS, CNR1, COMT, BDNF, GAD2
30epinephrine45 11 2411.9POMC, BDNF, COMT, MAOA, DDC, CYP1A2
31pyridoxal 5-phosphate459.9ABAT, GLS, GAD1, POMC, GAD2, COMT
326-hydroxydopamine459.9MAOA, COMT, DDC, BDNF
33diazepam45 50 29 1112.9POMC, BDNF, ABAT, CYP1A2
34norepinephrine45 11 2411.9CNR1, DDC, BDNF, POMC, CYP1A2, GLUL
35levodopa45 1110.8GAD2, ABAT, GAD1, DDC, COMT, MAOA
36choline45 11 2411.8DDC, COMT, BDNF, GLS, MAOA, GAD1
37glutamine459.8ALDH5A1, GAD1, POMC, ABAT, GLS2, GLUL
38dopamine45 29 11 2412.8GAD1, ABAT, CNR1, MAOA, COMT, BDNF
39nicotine45 50 29 1112.8CYP1A2, MAOA, ABAT, CNR1, COMT
40ethanol45 50 11 2412.8GLUL, ABAT, COMT, ALDH3A1, ALDH3B1, CYP1A2
41nadph45 2410.7ABAT, ALDH3A1, GAD1, BDNF, ALDH3B1, CYP1A2
42vanillylmandelic acid45 2410.7COMT, ALDH3A1, ALDH3B1
43aspartate459.7GLUL, ABAT, GAD1, GLS2, CNR1, BDNF
44arginine459.6TNFRSF1B, POMC, GLS, GAD1, GLUL, GLS2
45glucose459.6ABAT, POMC, TNFRSF1B, GAD2, GAD1, DDC
46alanine459.3DDC, ALDH5A1, GAD1, GADD45A, CNR1, GLS
47h2o2459.3TNFRSF1B, BDNF, GAD1, MAOA, GADD45A, POMC
48gaba459.2DDC, ALDH5A1, GLS2, GLUL, GLS, CNR1
49oxygen45 2410.2CYP1A2, GLS2, GLUL, GLS, MAOA, GADD45A
50glutamate459.2PAX6, ABAT, GLS2, GLUL, GLS, CNR1

GO Terms for genes affiliated with Paranoid Schizophrenia

Sources:
16Gene Ontology
See all sources

Cellular components related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:0612029.9GAD1, GAD2
2mitochondrial matrixGO:0057599.9ALDH5A1, ABAT, GLS2, GLS
3mitochondrionGO:0057399.3ALDH5A1, COMT, GLS, GLUL, GLS2, YWHAZ

Biological processes related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1gamma-aminobutyric acid catabolic processGO:00945010.3ALDH5A1, ABAT
2glutamate decarboxylation to succinateGO:00654010.3GAD2, GAD1
3dopamine catabolic processGO:04242010.3COMT, MAOA
4cellular amino acid biosynthetic processGO:00865210.3GLS2, GLS, GLUL
5neurotransmitter biosynthetic processGO:04213610.3COMT, MAOA, GAD1, GAD2
6neurotransmitter catabolic processGO:04213510.2ABAT, MAOA, COMT, ALDH5A1
7glutamate catabolic processGO:00653810.2GAD1, GLUL
8methylationGO:03225910.2COMT, CYP1A2
9glutamate secretionGO:01404710.2BDNF, GLS, GLS2
10behaviorGO:00761010.2ABAT, MAOA, CNR1, GLS
11response to drugGO:0424939.9COMT, GAD2, GAD1, ABAT, ALDH3A1
12neurotransmitter secretionGO:0072699.8ABAT, GAD2, GAD1, MAOA, GLS, GLS2
13cellular nitrogen compound metabolic processGO:0346419.8GLS2, GLUL, GLS, DDC
14synaptic transmissionGO:0072689.6GLUL, ALDH5A1, ABAT, GLS2, COMT, GAD2
15small molecule metabolic processGO:0442819.2MAOA, DDC, GLS, GLUL, GLS2, CYP1A2

Molecular functions related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylase activityGO:00435110.2GLUL, GAD1, GAD2
2glutamate bindingGO:01659510.2GLUL, GAD1, GAD2
3aldehyde dehydrogenase [NAD(P)+] activityGO:00403010.1ALDH3A1, ALDH3B1
4glutaminase activityGO:00435910.1GLS2, GLS
5pyridoxal phosphate bindingGO:0301709.9GAD2, GAD1, DDC, ABAT
63-chloroallyl aldehyde dehydrogenase activityGO:0040289.8ALDH3A1, ALDH3B1

Products for genes affiliated with Paranoid Schizophrenia

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Sources for Paranoid Schizophrenia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet