MCID: PRN009
MIFTS: 53

Paranoid Schizophrenia malady

Mental diseases category
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Summaries for Paranoid Schizophrenia

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A schizophrenia that involves delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening.

MalaCards: Paranoid Schizophrenia, also known as chronic paranoid schizophrenia, is related to schizophrenia and parkinson's disease. An important gene associated with Paranoid Schizophrenia is COMT (catechol-O-methyltransferase), and among its related pathways are Tyrosine metabolism p.1 dopamine and Phenylalanine metabolism. The drug chlorprothixene and the compounds dopeg and 3-methoxytyramine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Wikipedia:65 Paranoid schizophrenia, also called schizophrenia, paranoid type is a sub-type of schizophrenia as... more...

Aliases & Classifications for Paranoid Schizophrenia

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Sources:
8Disease Ontology, 45Novoseek, 62UMLS, 27ICD9CM, 58SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

paranoid schizophrenia 8 45 62
chronic paranoid schizophrenia 8 62
paranoid type schizophrenia subchronic state 8
paranoid type schizophrenia 8
paraphrenic schizophrenia 8
paraphrenia - late 8


Related Diseases for Paranoid Schizophrenia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Paranoid Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.9GLS, MAOA, COMT, CCKAR
2parkinson's disease30.4MAOA, COMT
3obsessive-compulsive disorder30.3COMT, MAOA
4psychotic disorder30.3MAOA, COMT
5mood disorder30.3MAOA, COMT
6dementia30.2COMT, MAOA, GLS
7mental retardation30.2COMT, MAOA, ALDH5A1
8delusional disorder10.4
9blindness10.4
10klinefelter's syndrome10.3
11vascular dementia10.1
12narcolepsy10.1
13major depressive disorder10.1
14capgras syndrome10.1
15alexithymia10.1
16priapism10.1
17peripartum cardiomyopathy10.1
18post-traumatic stress disorder10.1
19ulcerative colitis10.1
20mutism10.1
21kallmann syndrome10.1
22graves' disease10.1
23alcohol dependence10.1
24neuroleptic malignant syndrome10.1
25esophagitis10.1
26factitious disorder10.1
27influenza10.1
28personality disorder10.1
29scleroderma10.1
30thyroiditis10.1
31brain injury10.1
32traumatic brain injury10.1
33generalized anxiety disorder10.1MAOA
34antisocial personality disorder10.1MAOA
35social phobia10.1MAOA, COMT
36conduct disorder10.1COMT, MAOA
37bulimia nervosa10.1MAOA, COMT
38gilles de la tourette syndrome10.1MAOA, COMT
39anxiety disorder10.0MAOA, COMT
40attention deficit hyperactivity disorder10.0COMT, MAOA
41hepatic encephalopathy10.0GLS, MAOA
42anorexia nervosa10.0COMT, MAOA
43eating disorder10.0COMT, CCKAR
44migraine10.0MAOA, COMT
45bipolar disorder10.0MAOA, COMT
46pancreatic cancer10.0MAOA, CCKAR
47panic disorder10.0MAOA, COMT, CCKAR
48obesity10.0MAOA, COMT, CCKAR
49alzheimer's disease10.0COMT, MAOA, GLS

Graphical network of the top 20 diseases related to Paranoid Schizophrenia:



Diseases related to paranoid schizophrenia

Symptoms for Paranoid Schizophrenia

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Drugs & Therapeutics for Paranoid Schizophrenia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Paranoid Schizophrenia

Search NIH Clinical Center for Paranoid Schizophrenia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Paranoid Schizophrenia

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Anatomical Context for Paranoid Schizophrenia

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33MalaCards
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MalaCards organs/tissues related to Paranoid Schizophrenia:

33
Testes, Brain, Eye, Pituitary, Thyroid, Cortex, Amygdala, Prefrontal cortex

Animal Models for Paranoid Schizophrenia or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Paranoid Schizophrenia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.8CCKAR, COMT, ALDH5A1, FADS2
2MP:00053767.6FADS2, CCKAR, COMT, MAOA, ALDH5A1
3MP:00053867.0MAOA, FADS2, GLS, ALDH5A1, CCKAR, COMT

Publications for Paranoid Schizophrenia

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Sources:
52PubMed
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Articles related to Paranoid Schizophrenia:

(show top 50)    (show all 258)
idTitleAuthorsYear
1
Lack of association of IL-6 (-174 G>C) and TNF-I+ (-238 G>A) variants with paranoid schizophrenia in Indian Bengalee population. (23265967)
2013
2
Abnormal auditory sensory gating-out in first-episode and never-medicated paranoid schizophrenia patients: an fMRI study. (23820976)
2013
3
BDNF val66met polymorphism is associated with age at onset and intensity of symptoms of paranoid schizophrenia in a Polish population. (23487199)
2013
4
Kallmann syndrome and paranoid schizophrenia: a rare combination. (23329708)
2013
5
Capgras delusion in paranoid schizophrenia complicated by vascular dementia. (23037670)
2012
6
Positron emission tomography experience with 2-[A^a8,F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[A^a8,F]FA) in the living human brain of smokers with paranoid schizophrenia. (22169936)
2012
7
Association study of interferon gamma (IFN-I^) +874T/A gene polymorphism in patients with paranoid schizophrenia. (20821074)
2011
8
Different aspects of theory of mind in paranoid schizophrenia: evidence from a video-based assessment. (20947175)
2011
9
Functional polymorphism in the interleukin-6 and interleukin-10 genes in patients with paranoid schizophrenia--a case-control study. (20393813)
2010
10
Sensitization, epileptic-like symptoms and local synchronization in patients with paranoid schizophrenia. (19878702)
2010
11
Olanzapine-induced neuroleptic malignant syndrome in a patient with paranoid schizophrenia. (19067992)
2009
12
The influence of emotion clarity on emotional prosody identification in paranoid schizophrenia. (19000339)
2009
13
Neuropsychological relationships in paranoid schizophrenia with and without delusional misidentification syndromes. A comparative study. (18539375)
2008
14
EEG phase synchronization in patients with paranoid schizophrenia. (18835328)
2008
15
Relationship between cardiovagal modulation and psychotic state in patients with paranoid schizophrenia. (17919737)
2008
16
Prolactin and estradiol serum levels in unmedicated male paranoid schizophrenia patients. (17110010)
2007
17
Functional disintegration in paranoid schizophrenia using resting-state fMRI. (17628434)
2007
18
Aberrantly flattened responsivity to emotional pictures in paranoid schizophrenia. (16884781)
2006
19
Genetic associations between delusional disorder and paranoid schizophrenia: A novel etiologic approach. (16786814)
2006
20
A patient's journey: living with paranoid schizophrenia. (16990323)
2006
21
Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. (14992974)
2004
22
Factor structure of paranoid schizophrenia: a prospective study. (12845284)
2003
23
Anterior cingulate metabolism correlates with stroop errors in paranoid schizophrenia patients. (11377927)
2001
24
Insight in paranoid schizophrenia--its relationship to psychopathology and premorbid adjustment. (9777276)
1998
25
Sex-specific expression of Heschl's gyrus functional and structural abnormalities in paranoid schizophrenia. (9396942)
1997
26
Conjugate lateral eye movements during exacerbation of paranoid schizophrenia and the acute episode of major depression. (9129787)
1997
27
Maintenance ECT for treatment of therapy-resistant paranoid schizophrenia and Parkinson's disease. (7548464)
1995
28
The Capgras syndrome in paranoid schizophrenia. (1448540)
1992
29
Wisconsin Card Sorting Test deficits in chronic paranoid schizophrenia. Evidence for a relatively discrete subgroup? (1515378)
1992
30
Paranoid schizophrenia: prognosis under DSM-II and DSM-III-R. (2731425)
1989
31
A three-year prospective follow-up of psychopathology and social reintegration in paranoid schizophrenia in relation to age at onset. (3399822)
1988
32
Motor and sighting dominance in schizophrenia and affective disorder. Evidence for right-hand grip strength prominence in paranoid schizophrenia and bipolar illness. (4016461)
1985
33
Is loxapine more effective than chlorpromazine in paranoid schizophrenia? (6388362)
1984
34
Illusory correlations in paranoid and non-paranoid schizophrenia. (6487859)
1984
35
Post-traumatic stress disorder masquerading as paranoid schizophrenia: case report. (6817230)
1982
36
Cross-cultural study of a biochemical abnormality in paranoid schizophrenia. (6948314)
1981
37
Paranoid schizophrenia and platelet MAO activity. (7435694)
1980
38
Possible implication of an inosinetriphosphate metabolic error and glutamic acid decarboxylase in paranoid schizophrenia. (110320)
1979
39
Manic-depressive illness or paranoid schizophrenia? (290045)
1979
40
Split decision: critique of complete audit of paranoid schizophrenia. (103052)
1978
41
Nursing care study. Paranoid schizophrenia: learning to cope with eccentricity. (252023)
1978
42
Iowa 500: the clinical and genetic distinction of hebephrenic and paranoid schizophrenia. (4835424)
1974
43
PARANOID SCHIZOPHRENIA IN A PATIENT WITH KLINEFELTER'S SYNDROME. (14220862)
1964
44
The Rorschach "eyes' hypothesis and paranoid schizophrenia. (13887991)
1962
45
A double-blind trial to investigate the effects of Thorazine (Largactil, chlorpromazine), Compazine (Stemetil, prochlorperazine) and Stelazine (trifluoperazine) in paranoid schizophrenia. (13785665)
1961
46
A short scale for rating paranoid schizophrenia. (13841648)
1959
47
Clinical aspects of paraphrenic (delusional paranoid) schizophrenia]. (13605174)
1958
48
Prognosis in paranoid schizophrenia on the basis of the Rorschach. (13061662)
1953
49
A dynamic factor correlated with the prognosis in paranoid schizophrenia. (14818482)
1951
50
The place of paranoid states in psychiatric classification with special reference to paranoid schizophrenia. (18875667)
1948

Variations for Paranoid Schizophrenia

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Expression for genes affiliated with Paranoid Schizophrenia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paranoid Schizophrenia

Search GEO for disease gene expression data for Paranoid Schizophrenia.

Pathways for genes affiliated with Paranoid Schizophrenia

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Sources:
50PathCards, 60Thomson Reuters, 30KEGG, 38NCBI BioSystems Database, 55Reactome
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Pathways related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MAOA, COMT
2
Show member pathways
phenylalanine utilization38
noradrenaline and adrenaline degradation38
phenylalanine degradation IV38
9.6COMT, MAOA
3
Show member pathways
catecholamine biosynthesis38
9.6COMT, MAOA
49.6COMT, MAOA
59.6COMT, MAOA
6
Show member pathways
9.6MAOA, COMT
7
Show member pathways
citrulline-nitric oxide cycle38
arginine degradation I (arginase pathway)38
proline degradation38
glutamine degradation I38
proline biosynthesis I38
superpathway of citrulline metabolism38
proline biosynthesis II (from arginine)38
citrulline biosynthesis38
arginine degradation VI (arginase 2 pathway)38
Urea cycle and metabolism of amino groups38
asparagine biosynthesis I38
4-hydroxyproline degradation I38
citrulline degradation38
9.5MAOA, GLS
89.4ALDH5A1, GLS
9
Show member pathways
9.1COMT, MAOA, GLS
10
Show member pathways
9.0GLS, ALDH5A1, MAOA
11
Show member pathways
8.6COMT, MAOA, ALDH5A1, GLS
12
Show member pathways
7.7MAOA, COMT, FADS2, ALDH5A1, GLS

Compounds for genes affiliated with Paranoid Schizophrenia

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 29IUPHAR
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Compounds related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1dopeg4510.0MAOA, COMT
23-methoxytyramine45 2411.0COMT, MAOA
3nialamide45 1111.0COMT, MAOA
4normetanephrine45 2411.0COMT, MAOA
5metanephrine45 2411.0COMT, MAOA
6dopac4510.0MAOA, COMT
7mhpg4510.0COMT, MAOA
8methylphenidate45 51 1112.0COMT, MAOA
9maoa4510.0COMT, MAOA
10homovanillic acid45 2411.0COMT, MAOA
11fluvoxamine45 51 1112.0COMT, MAOA
12tyramine45 29 2412.0COMT, MAOA
13selegiline45 1111.0MAOA, COMT
14paroxetine45 51 29 1113.0COMT, MAOA
15methamphetamine45 51 1111.9COMT, MAOA
166-hydroxydopamine459.9MAOA, COMT
17mptp459.9COMT, MAOA
18levodopa45 1110.9MAOA, COMT
19pyridoxal 5-phosphate459.8COMT, GLS
20Ammonia249.8MAOA, GLS
21amine459.8COMT, MAOA
22benzodiazepines459.8MAOA, CCKAR
23vitamin b6459.8GLS, ALDH5A1
24benzodiazepine459.8MAOA, CCKAR
25catecholamine459.8COMT, MAOA
26succinate459.8MAOA, ALDH5A1
27n-ethylmaleimide45 1110.7MAOA, GLS
28alpha-ketoglutarate459.7ALDH5A1, GLS
29carbon459.6MAOA, COMT
30nad+459.6ALDH5A1, GLS
31morphine45 51 29 1112.5CCKAR, COMT
32choline45 24 1111.5GLS, MAOA, COMT
33nmda45 2910.4GLS, MAOA, COMT
34cocaine45 1110.3CCKAR, COMT
35dopamine45 29 24 1112.3COMT, MAOA, CCKAR
365-hydroxytryptamine459.3COMT, MAOA
37glutamine459.1CCKAR, ALDH5A1, GLS
38Water249.1GLS, ALDH5A1, MAOA
39glutamate459.0COMT, MAOA, ALDH5A1, GLS
40alanine458.8CCKAR, ALDH5A1, GLS
41gaba458.8MAOA, ALDH5A1, GLS, CCKAR

GO Terms for genes affiliated with Paranoid Schizophrenia

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16Gene Ontology
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Cellular components related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:0057398.6GLS, ALDH5A1, MAOA, COMT

Biological processes related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:0424209.7MAOA, COMT
2neurotransmitter biosynthetic processGO:0421369.6MAOA, COMT
3xenobiotic metabolic processGO:0068059.6COMT, MAOA
4neurotransmitter catabolic processGO:0421359.3COMT, MAOA, ALDH5A1
5protein homotetramerizationGO:0512899.1GLS, ALDH5A1
6neurotransmitter secretionGO:0072699.1MAOA, GLS, ALDH5A1
7synaptic transmissionGO:0072688.7ALDH5A1, GLS, COMT, MAOA
8small molecule metabolic processGO:0442818.2MAOA, GLS, FADS2, COMT

Products for genes affiliated with Paranoid Schizophrenia

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Sources for Paranoid Schizophrenia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet