MCID: PRN009
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Paranoid Schizophrenia malady

Neuronal diseases category

Summaries for Paranoid Schizophrenia

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A schizophrenia that involves delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening.

MalaCards: Paranoid Schizophrenia, also known as chronic paranoid schizophrenia, is related to schizophrenia and psychotic disorder. An important gene associated with Paranoid Schizophrenia is COMT (catechol-O-methyltransferase), and among its related pathways are Taurine and hypotaurine metabolism and GABA synthesis. The drug chlorprothixene and the compounds succinic semialdehyde and oleamide have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related mouse phenotypes are respiratory system and no phenotypic analysis.

Wikipedia:63 Paranoid schizophrenia, also called schizophrenia, paranoid type is a sub-type of schizophrenia as... more...

Aliases & Classifications for Paranoid Schizophrenia

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

paranoid schizophrenia 8 44 60
chronic paranoid schizophrenia 8 60
paranoid type schizophrenia subchronic state 8
paranoid type schizophrenia 8
paraphrenic schizophrenia 8
paraphrenia - late 8


Related Diseases for Paranoid Schizophrenia

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17GeneCards, 18GeneDecks
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Diseases related to Paranoid Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.9GLS, PAX6, CYP1A2, GLUL, CNR1, MAOA
2psychotic disorder30.4MAOA, CNR1, BDNF, GAD1, COMT
3parkinson's disease30.4COMT, CNR1, MAOA, BDNF, GAD2, DDC
4alcohol dependence30.1MAOA, CNR1
5thyroiditis30.1GAD2, POMC
6narcolepsy30.1TNFRSF1B, COMT
7obsessive-compulsive disorder30.1MAOA, BDNF, COMT
8dementia30.1MAOA, COMT, BDNF, GLS, TNFRSF1B
9graves' disease30.1GAD2, GAD1, DDC
10mood disorder30.1POMC, MAOA, CNR1, BDNF, COMT, GAD1
11bipolar disorder30.1BDNF, GAD1, DDC, COMT, MAOA, CNR1
12delusional disorder10.3
13klinefelter's syndrome10.3
14vascular dementia10.1
15capgras syndrome10.1
16major depressive disorder10.1
17kallmann syndrome10.1
18paranoid personality disorder10.1
19alexithymia10.1
20priapism10.1
21peripartum cardiomyopathy10.1
22post-traumatic stress disorder10.1
23ulcerative colitis10.1
24mutism10.1
25neuroleptic malignant syndrome10.1
26large cell carcinoma10.1
27esophagitis10.1
28factitious disorder10.1
29influenza10.1
30personality disorder10.1
31scleroderma10.1
32squamous cell carcinoma10.1
33fibromyalgia10.0COMT
34substance abuse10.0CNR1
35autoimmune polyendocrine syndrome10.0DDC
36borderline personality disorder10.0MAOA
37galactosemia10.0CYP1A2
38intellectual disability10.0PAX6
39l-2-hydroxyglutaric aciduria10.0GLS2
40hepatitis c10.0CYP1A2
41hypertension10.0POMC
42neuroblastoma10.0BDNF
43lung cancer10.0POMC
44substance dependence10.0COMT, CNR1
45lennox-gastaut syndrome10.0ABAT
46drug dependence10.0MAOA, CNR1
47cocaine dependence10.0POMC
48schizoaffective disorder10.0COMT, BDNF
49encephalitis10.0GAD2, CNR1
50cannabis dependence10.0CNR1

Graphical network of the top 20 diseases related to Paranoid Schizophrenia:



Diseases related to paranoid schizophrenia

Clinical Features for Paranoid Schizophrenia

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Drugs & Therapeutics for Paranoid Schizophrenia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Paranoid Schizophrenia

Drug clinical trials:

Search ClinicalTrials for Paranoid Schizophrenia

Search NIH Clinical Center for Paranoid Schizophrenia

Search CenterWatch for Paranoid Schizophrenia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Paranoid Schizophrenia

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Anatomical Context for Paranoid Schizophrenia

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32MalaCards
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MalaCards organs/tissues related to Paranoid Schizophrenia:

32
Testes, Brain, Eye, Pituitary, Thyroid, Amygdala, Cortex, Prefrontal cortex

Animal Models for Paranoid Schizophrenia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Paranoid Schizophrenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.6BDNF, TNFRSF1B, GAD2, GAD1, GLS, CYP1A2
2MP:00030129.6GAD2, GAD1, POMC, CNR1, CYP1A2, BDNF
3MP:00053679.5COMT, TNFRSF1B, GADD45A, DDC, POMC, PAX6
4MP:00053859.0COMT, TNFRSF1B, GADD45A, DDC, POMC, MAOA
5MP:00053788.9BDNF, GAD2, GAD1, GADD45A, DDC, POMC
6MP:00036318.8COMT, BDNF, TNFRSF1B, GAD2, GAD1, GADD45A
7MP:00053868.8ALDH5A1, COMT, BDNF, TNFRSF1B, GAD2, GAD1
8MP:00107688.7GADD45A, GAD1, GAD2, TNFRSF1B, BDNF, DDC
9MP:00053768.7GADD45A, GAD1, GAD2, TNFRSF1B, BDNF, COMT

Publications for Paranoid Schizophrenia

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Sources:
50PubMed
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Articles related to Paranoid Schizophrenia:

(show top 50)    (show all 272)
idTitleAuthorsYear
1
Lack of association of IL-6 (-174 G>C) and TNF-I+ (-238 G>A) variants with paranoid schizophrenia in Indian Bengalee population. (23265967)
2013
2
Abnormal auditory sensory gating-out in first-episode and never-medicated paranoid schizophrenia patients: an fMRI study. (23820976)
2013
3
Paranoid personality disorder and the schizophrenia spectrum-Where to draw the line? (24343968)
2013
4
Clinico-epidemiological comparison of delusion prominent and hallucination prominent clinical subgroups of paranoid schizophrenia. (23518786)
2013
5
A case of paranoid schizophrenia and severe antipsychotic-induced Parkinson's disorder treated with a combination of olanzapine and lurasidone. (24307974)
2013
6
Capgras delusion in paranoid schizophrenia complicated by vascular dementia. (23037670)
2012
7
Delusional disorders--are they simply paranoid schizophrenia? (21078814)
2012
8
Association study between BDNF C-281A polymorphism and paranoid schizophrenia in Polish population. (21710362)
2012
9
Religious content of hallucinations in paranoid schizophrenia. (22945191)
2012
10
Facial emotion linked cooperation in patients with paranoid schizophrenia: a test on the Interpersonal Communication Model. (20603270)
2011
11
A case-control study between gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and paranoid schizophrenia of Han ethnicity in Jilin Province]. (21560298)
2011
12
Is the highest density of CB1 receptors in paranoid schizophrenia a correlate of endocannabinoid system functioning? (21797651)
2011
13
Differential responses to emotional interference in paranoid schizophrenia and bipolar mania. (20980782)
2011
14
Quantitative criteria of narrative coherence and complexity in persons with paranoid schizophrenia. (20458197)
2010
15
Large squamous cell carcinoma of the face and paranoid schizophrenia: a calamitous combination. (20642803)
2010
16
An exploratory analysis of neurocognition in methamphetamine-induced psychotic disorder and paranoid schizophrenia. (18541986)
2008
17
Lamotrigine-associated exacerbation of positive symptoms in paranoid schizophrenia. (17851040)
2008
18
Prolactin serum levels in paranoid versus nonparanoid male schizophrenia patients treated with risperidone. (17519641)
2007
19
Aberrantly flattened responsivity to emotional pictures in paranoid schizophrenia. (16884781)
2006
20
Association of functional genes polymorphisms of key enzymes in the metabolism of biogenic amines with paranoid schizophrenia susceptibility and the influence of these polymorphisms on PANSS results in antipsychotic treatment]. (17217235)
2006
21
Greater impairment in negative emotion evaluation ability in patients with paranoid schizophrenia. (16807983)
2006
22
Paranoid schizophrenia and idiopathic Parkinson's disease do coexist: a challenge for clinicians. (16958952)
2006
23
A case of de ClAcrambault syndrome in a male stalker with paranoid schizophrenia. (15362260)
2004
24
'Theory of mind' in violent and nonviolent patients with paranoid schizophrenia. (15145470)
2004
25
The influence of some antipsychotics on erythrocyte magnesium and plasma magnesium, calcium, copper and zinc in patients with paranoid schizophrenia. (15466963)
2004
26
Characteristics of trees drawn by patients with paranoid schizophrenia. (12839513)
2003
27
Anterior cingulate metabolism correlates with stroop errors in paranoid schizophrenia patients. (11377927)
2001
28
Jerusalem syndrome or paranoid schizophrenia? (11058201)
2000
29
Psychotic relapse and maintenance therapy in paranoid schizophrenia: a 15 year follow up. (10369153)
1999
30
Insight in paranoid schizophrenia--its relationship to psychopathology and premorbid adjustment. (9777276)
1998
31
On an engaging patient with paranoid schizophrenia. (9247427)
1997
32
On an engaging patient with paranoid schizophrenia. (9247426)
1997
33
Rehabilitation psychiatry in the inpatient treatment of a woman with paranoid schizophrenia. (7868098)
1994
34
Violence and paranoid schizophrenia. (7995685)
1994
35
Paranoid schizophrenia: prognosis under DSM-II and DSM-III-R. (2731425)
1989
36
A three-year prospective follow-up of psychopathology and social reintegration in paranoid schizophrenia in relation to age at onset. (3399822)
1988
37
Is paranoid schizophrenia really camouflaged depression? (3382102)
1988
38
Paranoid schizophrenia and homosexuality: a case study. (7139150)
1982
39
Demography of paranoid psychosis (delusional disorder): a review and comparison with schizophrenia and affective illness. (7103678)
1982
40
Paranoid psychosis (delusional disorder) and schizophrenia. A family history study. (7235856)
1981
41
Amphetamine models of paranoid schizophrenia: an overview and elaboration of animal experimentation. (7003640)
1980
42
HLA--Cw4 in paranoid schizophrenia. (850917)
1977
43
Effects of chronic d-amphetamine on social behavior of the rat: implications for an animal model of paranoid schizophrenia. (826965)
1976
44
Criteria for subtyping schizophrenia. Clinical differentiation of hebephrenic and paranoid schizophrenia. (4599411)
1974
45
Projection of eyes in paranoid schizophrenia. (4557227)
1972
46
Chronic paranoid schizophrenia complicated by epilepsy. (4989879)
1970
47
Intercorrelation of Orgel's diagnostic rating criteria with other measures of paranoid schizophrenia. (5917885)
1966
48
Acute paranoid schizophrenia. (Treatment with chlorpromazine, trifluoperazine and placebo). (5936140)
1966
49
PARANOID SCHIZOPHRENIA IN A PATIENT WITH KLINEFELTER'S SYNDROME. (14220862)
1964
50
VICISSITUDES OF INTERNALIZED OBJECTS IN PARANOID SCHIZOPHRENIA AND MANIC-DEPRESSIVE STATES. (14073181)
1963

Genetic Variations for Paranoid Schizophrenia

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Expression for genes affiliated with Paranoid Schizophrenia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paranoid Schizophrenia

Search GEO for disease gene expression data for Paranoid Schizophrenia.

Pathways for genes affiliated with Paranoid Schizophrenia

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Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB
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Pathways related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2GAD1, GAD2
210.2GAD1, GAD2
3
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10.2CYP1A2, MAOA
4
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10.2ALDH5A1, ABAT
5
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10.2GLS2, GLS
6
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10.1COMT, DDC, MAOA
710.1GLUL, GAD1, GAD2
8
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10.1ALDH3B1, ALDH3A1
9
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10.1CYP1A2, MAOA, DDC
10
Hide members
10.1CYP1A2, MAOA, DDC
1110.1ABAT, GAD1, GAD2
1210.1ABAT, GAD1, GAD2
13
Hide members
10.1ABAT, GAD1, GAD2
14
Hide members
10.0GLS2, GLS, MAOA
1510.0GLS2, GLUL, GLS
16
Hide members
10.0CYP1A2, ALDH3A1, ALDH5A1
17
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10.0MAOA, DDC, GAD1, GAD2
189.9MAOA, GLS, GLUL, GLS2
19
Tyrosine metabolism p.1 (dopamine)
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9.9COMT, DDC, MAOA, ALDH3A1
209.9DDC, GLS, GLUL, GLS2
219.8DDC, MAOA, ALDH3B1, ALDH3A1
229.8BDNF, DDC, MAOA, YWHAZ
23
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9.8MAOA, CYP1A2, ALDH3B1, ALDH3A1
24
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9.7ALDH3A1, ALDH3B1, MAOA, DDC, COMT
259.7GAD2, GAD1, ABAT, ALDH3B1, ALDH3A1
26
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9.5GAD2, GAD1, MAOA, GLS, GLS2, ABAT
279.5ALDH5A1, GAD2, GAD1, GLS, GLUL, GLS2
28
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9.3COMT, GAD2, GAD1, MAOA, GLS, GLUL
29
Hide members
9.3COMT, GAD2, GAD1, DDC, MAOA, GLS
30
Hide members
9.1COMT, GAD2, GAD1, DDC, MAOA, CNR1

Compounds for genes affiliated with Paranoid Schizophrenia

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1succinic semialdehyde4410.4GAD1, ABAT, ALDH5A1
2oleamide44 28 2412.4CNR1, DDC, MAOA
3mhpg4410.3DDC, MAOA, BDNF, COMT
4vigabatrin44 28 1112.3ALDH5A1, ABAT, POMC
5maoa4410.3COMT, BDNF, POMC, MAOA
6quinolinic acid44 2411.3BDNF, GAD1, GLUL, GLS
7heroin44 49 1112.3CNR1, POMC, COMT, ABAT
8paroxetine44 49 28 1113.3BDNF, CYP1A2, COMT, MAOA
93,4-dihydroxyphenylacetaldehyde44 2411.2ALDH3B1, ALDH3A1, MAOA
10taurine44 59 2412.2GAD1, GLS, ABAT, GAD2
11selegiline44 1111.2BDNF, DDC, COMT, MAOA, CYP1A2
12vitamin b64410.2ALDH5A1, GAD1, GLS, ABAT, DDC
13desipramine44 49 1112.1BDNF, CNR1, CYP1A2, MAOA
14famotidine44 2 11 2413.1ABAT, GAD1, GAD2, GLS2, GLS
15phenylacetaldehyde44 2411.1ALDH3B1, ALDH3A1, MAOA
16ornithine44 2411.1GAD2, GAD1, ABAT, GLUL, GLS
17catecholamine4410.1MAOA, POMC, DDC, BDNF, COMT
18mptp4410.1COMT, BDNF, GAD1, MAOA, DDC, GAD2
19bromocriptine28 44 1112.1COMT, CYP1A2, POMC, DDC
20fluoxetine49 44 28 1113.1CYP1A2, BDNF, MAOA, CNR1
21alpha-ketoglutarate4410.1ABAT, GLS2, GLUL, GLS, GAD1, ALDH5A1
22l-glutamic acid28 11 2412.0GAD2, GAD1, GLS, GLS2, GLUL, ABAT
235-hydroxytryptamine4410.0CNR1, COMT, MAOA, DDC, POMC
24clozapine44 28 49 1113.0GAD1, CYP1A2, TNFRSF1B, POMC, COMT, BDNF
25cocaine44 1111.0COMT, BDNF, ABAT, CNR1, POMC
26homovanillic acid44 2411.0BDNF, ALDH3B1, ALDH3A1, MAOA, DDC, COMT
27valproic acid44 49 11 2413.0BDNF, GAD1, POMC, CYP1A2, ABAT, ALDH5A1
28Pyridoxal Phosphate1110.0ABAT, GAD2, DDC, GAD1
29nmda44 2811.0GAD1, GLS, CNR1, COMT, BDNF, GAD2
30epinephrine44 11 2411.9POMC, BDNF, COMT, MAOA, DDC, CYP1A2
31pyridoxal 5-phosphate449.9ABAT, GLS, GAD1, POMC, GAD2, COMT
326-hydroxydopamine449.9MAOA, COMT, DDC, BDNF
33diazepam44 49 28 1112.9POMC, BDNF, ABAT, CYP1A2
34norepinephrine44 11 2411.9CNR1, DDC, BDNF, POMC, CYP1A2, GLUL
35levodopa44 1110.8GAD2, ABAT, GAD1, DDC, COMT, MAOA
36choline44 11 2411.8DDC, COMT, BDNF, GLS, MAOA, GAD1
37glutamine449.8ALDH5A1, GAD1, POMC, ABAT, GLS2, GLUL
38dopamine44 28 11 2412.8GAD1, ABAT, CNR1, MAOA, COMT, BDNF
39nicotine44 49 28 1112.8CYP1A2, MAOA, ABAT, CNR1, COMT
40ethanol44 49 11 2412.8GLUL, ABAT, COMT, ALDH3A1, ALDH3B1, CYP1A2
41nadph44 2410.7ABAT, ALDH3A1, GAD1, BDNF, ALDH3B1, CYP1A2
42vanillylmandelic acid44 2410.7COMT, ALDH3A1, ALDH3B1
43aspartate449.7GLUL, ABAT, GAD1, GLS2, CNR1, BDNF
44arginine449.6TNFRSF1B, POMC, GLS, GAD1, GLUL, GLS2
45glucose449.6ABAT, POMC, TNFRSF1B, GAD2, GAD1, DDC
46alanine449.3DDC, ALDH5A1, GAD1, GADD45A, CNR1, GLS
47h2o2449.3TNFRSF1B, BDNF, GAD1, MAOA, GADD45A, POMC
48gaba449.2DDC, ALDH5A1, GLS2, GLUL, GLS, CNR1
49oxygen44 2410.2CYP1A2, GLS2, GLUL, GLS, MAOA, GADD45A
50glutamate449.2PAX6, ABAT, GLS2, GLUL, GLS, CNR1

GO Terms for genes affiliated with Paranoid Schizophrenia

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16Gene Ontology
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Cellular components related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:0612029.9GAD1, GAD2
2mitochondrial matrixGO:0057599.9ALDH5A1, ABAT, GLS2, GLS
3mitochondrionGO:0057399.3ALDH5A1, COMT, GLS, GLUL, GLS2, YWHAZ

Biological processes related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylation to succinateGO:00654010.4GAD1, GAD2
2dopamine catabolic processGO:04242010.3COMT, MAOA
3gamma-aminobutyric acid catabolic processGO:00945010.3ALDH5A1, ABAT
4cellular amino acid biosynthetic processGO:00865210.3GLS, GLUL, GLS2
5neurotransmitter biosynthetic processGO:04213610.3COMT, GAD2, GAD1, MAOA
6neurotransmitter catabolic processGO:04213510.2COMT, MAOA, ABAT, ALDH5A1
7glutamate catabolic processGO:00653810.2GAD1, GLUL
8methylationGO:03225910.2CYP1A2, COMT
9glutamate secretionGO:01404710.2GLS2, GLS, BDNF
10behaviorGO:00761010.2ABAT, GLS, CNR1, MAOA
11response to drugGO:0424939.9COMT, GAD2, GAD1, ABAT, ALDH3A1
12neurotransmitter secretionGO:0072699.8ALDH5A1, GAD2, GAD1, MAOA, GLS, GLS2
13cellular nitrogen compound metabolic processGO:0346419.8GLS2, GLUL, GLS, DDC
14synaptic transmissionGO:0072689.6COMT, GAD2, GAD1, MAOA, GLS, GLUL
15small molecule metabolic processGO:0442819.2COMT, DDC, MAOA, GLS, GLUL, GLS2

Molecular functions related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylase activityGO:00435110.2GLUL, GAD1, GAD2
2glutamate bindingGO:01659510.2GLUL, GAD1, GAD2
3aldehyde dehydrogenase [NAD(P)+] activityGO:00403010.1ALDH3A1, ALDH3B1
4glutaminase activityGO:00435910.1GLS2, GLS
5pyridoxal phosphate bindingGO:0301709.9GAD2, GAD1, DDC, ABAT
63-chloroallyl aldehyde dehydrogenase activityGO:0040289.8ALDH3A1, ALDH3B1

Products for genes affiliated with Paranoid Schizophrenia

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Sources for Paranoid Schizophrenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet