MCID: PRN009
MIFTS: 49

Paranoid Schizophrenia

Categories: Mental diseases

Aliases & Classifications for Paranoid Schizophrenia

MalaCards integrated aliases for Paranoid Schizophrenia:

Name: Paranoid Schizophrenia 12 51 14 69
Chronic Paranoid Schizophrenia 12 69
Paranoid Type Schizophrenia Subchronic State 12
Paranoid Type Schizophrenia 12
Paraphrenic Schizophrenia 12
Schizophrenia, Paranoid 41
Paraphrenia - Late 12

Classifications:



Summaries for Paranoid Schizophrenia

Disease Ontology : 12 A schizophrenia that involves delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening.

MalaCards based summary : Paranoid Schizophrenia, also known as chronic paranoid schizophrenia, is related to alexithymia and traumatic brain injury. An important gene associated with Paranoid Schizophrenia is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways are Neuroscience and Amphetamine addiction. The drugs Cycloserine and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 72 Paranoid schizophrenia is the most common type of schizophrenia. Schizophrenia is defined as “a chronic... more...

Related Diseases for Paranoid Schizophrenia

Diseases related to Paranoid Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 alexithymia 29.9 COMT SLC6A4
2 traumatic brain injury 29.8 BDNF COMT S100B
3 brain injury 29.8 BDNF COMT S100B
4 schizoaffective disorder 29.7 BDNF COMT HTR2A SLC6A4
5 anxiety 29.2 BDNF COMT HTR2A MAOA SLC6A4 TPH2
6 post-traumatic stress disorder 29.2 BDNF COMT HTR2A MAOA SLC6A4
7 disease of mental health 29.2 BDNF COMT HTR2A MAOA SLC6A4
8 personality disorder 29.1 BDNF COMT HTR2A MAOA SLC6A4 TPH2
9 psychotic disorder 28.9 BDNF COMT HTR2A S100B SLC6A4
10 mood disorder 28.8 BDNF COMT HTR2A MAOA SLC6A4 TPH2
11 obsessive-compulsive disorder 28.8 BDNF COMT HTR2A MAOA SLC6A4 TPH2
12 autism spectrum disorder 28.8 BDNF COMT HTR2A MAOA SLC6A4 TPH2
13 alcohol dependence 28.8 BDNF COMT HTR2A MAOA SLC6A4 TPH2
14 autism 28.8 BDNF COMT HTR2A MAOA SLC6A4 TPH2
15 major depressive disorder 28.4 BDNF COMT HTR2A MAOA NTRK2 SLC6A4
16 schizophrenia 28.2 BDNF CCKAR COMT HTR2A MAOA MIAT
17 phobia, specific 10.4 COMT MAOA
18 nodular ganglioneuroblastoma 10.3 BDNF NTRK2
19 tardive dyskinesia 10.3 COMT HTR2A
20 atypical depressive disorder 10.2 MAOA SLC6A4
21 vertebral artery occlusion 10.2 BDNF NTRK2
22 social phobia 10.2 MAOA SLC6A4
23 alzheimer disease 5 10.2 HTR2A SLC6A4
24 tobacco addiction 10.2 COMT HTR2A MAOA
25 kleptomania 10.2 MAOA SLC6A4
26 psychosexual disorder 10.1 HTR2A SLC6A4
27 premature ejaculation 10.1 COMT SLC6A4
28 alcoholic psychosis 10.1 HTR2A SLC6A4
29 tic disorder 10.1 HTR2A TPH2
30 periodic limb movement disorder 10.1 HTR2A SLC6A4
31 phobic disorder 10.1 COMT MAOA SLC6A4
32 brunner syndrome 10.1 COMT MAOA SLC6A4
33 antisocial personality disorder 10.1 COMT MAOA SLC6A4
34 bruxism 10.1 HTR2A SLC6A4
35 aging 10.1
36 delusional disorder 10.1
37 conduct disorder 10.1 COMT MAOA SLC6A4
38 eating disorder 10.0 BDNF COMT SLC6A4
39 specific developmental disorder 10.0 BDNF COMT SLC6A4
40 substance dependence 10.0 BDNF MAOA SLC6A4
41 dysthymic disorder 10.0 HTR2A MAOA SLC6A4
42 pathological gambling 10.0 HTR2A MAOA SLC6A4
43 agoraphobia 10.0 MAOA SLC6A4
44 serotonin syndrome 10.0 HTR2A MAOA SLC6A4
45 hypogonadotropic hypogonadism 10.0
46 epilepsy 10.0
47 mutism 10.0
48 dystonia 1, torsion, autosomal dominant 10.0 COMT MAOA
49 central nervous system disease 9.9 BDNF HTR2A SLC6A4
50 postpartum depression 9.9 BDNF COMT MAOA SLC6A4

Comorbidity relations with Paranoid Schizophrenia via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Alzheimer Disease
Deficiency Anemia Delusional Disorder
Hypertension, Essential Hypothyroidism
Major Depressive Disorder Paranoid Personality Disorder
Parkinson Disease, Late-Onset Protein-Energy Malnutrition
Schizophrenia Schizophreniform Disorder
Tardive Dyskinesia

Graphical network of the top 20 diseases related to Paranoid Schizophrenia:



Diseases related to Paranoid Schizophrenia

Symptoms & Phenotypes for Paranoid Schizophrenia

MGI Mouse Phenotypes related to Paranoid Schizophrenia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.96 NTRK2 S100B SLC18A1 SLC6A4 TPH2 BDNF
2 nervous system MP:0003631 9.76 NTRK2 SLC18A1 SLC6A4 TPH2 BDNF CCKAR
3 normal MP:0002873 9.43 NTRK2 S100B SLC18A1 SLC6A4 TPH2 BDNF
4 taste/olfaction MP:0005394 8.8 TPH2 BDNF CCKAR

Drugs & Therapeutics for Paranoid Schizophrenia

Drugs for Paranoid Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cycloserine Approved Phase 4 68-41-7 6234 401
2 Anti-Bacterial Agents Phase 4
3 Antibiotics, Antitubercular Phase 4
4 Anti-Infective Agents Phase 4
5 Antimetabolites Phase 4
6 Antitubercular Agents Phase 4
7 Renal Agents Phase 4
8
Risperidone Approved, Investigational Phase 2 106266-06-2 5073
9
Aripiprazole Approved, Investigational Phase 2 129722-12-9 60795
10
Olanzapine Approved, Investigational Phase 2 132539-06-1 4585
11 Antipsychotic Agents Phase 2
12 Quetiapine Fumarate Phase 2 111974-72-2
13 sultopride Phase 2
14
Dopamine Approved 51-61-6, 62-31-7 681
15 Central Nervous System Depressants
16 Dopamine Agents
17 Dopamine Antagonists
18 Neurotransmitter Agents
19 Psychotropic Drugs
20
Serotonin 50-67-9 5202
21 Serotonin Agents
22 Serotonin Antagonists
23 Tranquilizing Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Using D-cycloserine to Enhance the Benefits of Cognitive Behavioral Therapy for Schizophrenia Completed NCT00742079 Phase 4 D-cycloserine
2 MK0249 for the Treatment of Cognitive Impairment in Patients With Schizophrenia (0249-016) Completed NCT00506077 Phase 2 MK0249;Comparator: Placebo (unspecified)
3 MK0557 for the Treatment of Cognitive Impairment in Patients With Schizophrenia (0557-027) Completed NCT00482430 Phase 2 MK0557;Comparator: Placebo (unspecified)
4 Transcutaneous Non-invasive Vagus Nerve Stimulation (t-VNS) in the Treatment of Schizophrenia Completed NCT01176721 Phase 2
5 Enhancing Recovery in Early Schizophrenia Recruiting NCT02926859 Phase 2 Cannabidiol as add-on;Placebo as add-on
6 Evaluation of Efficacy and Safety of Long-acting Risperidone Microspheres in Patients With Schizophrenia or Other Psychotic Disorders When Switching From Typical Antipsychotic (Oral/Depot) or Atypical Oral Other Than Risperidone Unknown status NCT00563017 Long-acting Risperidone microspheres injection

Search NIH Clinical Center for Paranoid Schizophrenia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: schizophrenia, paranoid

Genetic Tests for Paranoid Schizophrenia

Anatomical Context for Paranoid Schizophrenia

MalaCards organs/tissues related to Paranoid Schizophrenia:

38
Testes, Brain, Eye, Pituitary, Amygdala, Thyroid, Cortex

Publications for Paranoid Schizophrenia

Articles related to Paranoid Schizophrenia:

(show top 50) (show all 308)
# Title Authors Year
1
Altered corticostriatal pathway in first-episode paranoid schizophrenia: Resting-state functional and causal connectivity analyses. ( 29122402 )
2018
2
Zotepine-induced convulsion at a low dose in a case of paranoid schizophrenia. ( 29363876 )
2018
3
Day/night changes in serum S100B protein concentrations in acute paranoid schizophrenia. ( 28188811 )
2017
4
Paranoid schizophrenia in a woman with Marfan syndrome. ( 29424882 )
2017
5
A three-month longitudinal study of changes in day/night serum total antioxidant capacity in paranoid schizophrenia. ( 29220388 )
2017
6
Short Sleep in Patients With Chronic Paranoid Schizophrenia. ( 28841274 )
2017
7
Intracranial Foreign Body in a Patient With Paranoid Schizophrenia. ( 28885436 )
2017
8
Treatment Compliance in the Long-Term Paranoid Schizophrenia Telemedicine Study. ( 29082310 )
2017
9
Successful treatment with risperidone increases 5-HT 3A receptor gene expression in patients with paranoid schizophrenia - data from a prospective study. ( 28948091 )
2017
10
Cognitive deficit in patients with paranoid schizophrenia: Its clinical and laboratory correlates. ( 28951142 )
2017
11
Association of the IFN-I^ (+874A/T) Genetic Polymorphism with Paranoid Schizophrenia in Tunisian Population. ( 27819519 )
2017
12
Low levels of serum total antioxidant capacity and presence at admission and absence at discharge of a day/night change as a marker of acute paranoid schizophrenia relapse. ( 28126575 )
2017
13
Evidence for Distinguishable Treatment Costs among Paranoid Schizophrenia and Schizoaffective Disorder. ( 27391238 )
2016
14
Huntington's disease in a patient with 15-year history of Capgras delusion misdiagnosed as paranoid schizophrenia. ( 26719104 )
2016
15
Discriminating between first- and second-order cognition in first-episode paranoid schizophrenia. ( 28005458 )
2016
16
GABAergic system impairment in the hippocampus and superior temporal gyrus of patients with paranoid schizophrenia: A post-mortem study. ( 26922657 )
2016
17
Variants in TERT influencing telomere length are associated with paranoid schizophrenia risk. ( 26799699 )
2016
18
IFNGR2 genetic polymorphism associated with sex-specific paranoid schizophrenia risk. ( 27563937 )
2016
19
Long term telemedicine study of compliance in paranoid schizophrenia. ( 26417777 )
2015
20
Spinocerebellar ataxia-10 with paranoid schizophrenia. ( 25745322 )
2015
21
Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients. ( 26925374 )
2015
22
Paranoid Schizophrenia versus Schizoaffective Disorder: Neuropsychological Aspects. ( 26506747 )
2015
23
A novel psychoactive substance poses a new challenge in the management of paranoid schizophrenia. ( 25948854 )
2015
24
[The Role of Neurotrophins and Neurexins Genes in the Risk of Paranoid Schizophrenia in Russians and Tatars]. ( 26410934 )
2015
25
Chronic non-fatal Datura abuse in a patient of paranoid schizophrenia: a case report. ( 25544354 )
2015
26
Abnormal inter- and intra-hemispheric integration in male paranoid schizophrenia: a graph-theoretical analysis. ( 26300598 )
2015
27
Evidence from paranoid schizophrenia for more than one component of theory of mind. ( 26579026 )
2015
28
Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia. ( 26315603 )
2015
29
Genetic variants in long non-coding RNA MIAT contribute to risk of paranoid schizophrenia in a Chinese Han population. ( 26004688 )
2015
30
A paired case-control comparison of ziprasidone on visual sustained attention and visual selective attention in patients with paranoid schizophrenia. ( 26367712 )
2015
31
Facial emotion recognition in paranoid schizophrenia and autism spectrum disorder. ( 25278104 )
2014
32
Ribosomal DNA transcription in the dorsal raphe nucleus is increased in residual but not in paranoid schizophrenia. ( 25091423 )
2014
33
EEG Theta Power and Coherence to Octave Illusion in First-Episode Paranoid Schizophrenia with Auditory Hallucinations. ( 25359515 )
2014
34
Alcohol abuse as the strongest risk factor for violent offending in patients with paranoid schizophrenia. ( 24778102 )
2014
35
Demographic features and premorbid personality disorder traits in relation to age of onset and sex in paranoid schizophrenia. ( 24495576 )
2014
36
Hiccups associated with switching from olanzapine to aripiprazole in a patient with paranoid schizophrenia. ( 24824665 )
2014
37
[The association of polymorphisms in SLC18A1, TPH1 and RELN genes with risk of paranoid schizophrenia]. ( 25842846 )
2014
38
Rapid Response of Long-Standing, Treatment-Resistant Non-Catatonic Mutism in Paranoid Schizophrenia with Single ECT session. ( 25535609 )
2014
39
Decreased resting-state interhemispheric coordination in first-episode, drug-naive paranoid schizophrenia. ( 24075897 )
2014
40
Is the comprehension of idiomatic sentences indeed impaired in paranoid Schizophrenia? A window into semantic processing deficits. ( 25346676 )
2014
41
Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese. ( 24668635 )
2014
42
Clozapine induced tubulointerstitial nephritis in a patient with paranoid schizophrenia. ( 24849641 )
2014
43
[Glutamate receptors genes polymorphism and the risk of paranoid schizophrenia in Russians and tatars from the Republic of Bashkortostan]. ( 25842862 )
2014
44
Genetic association between the dopamine D1-receptor gene and paranoid schizophrenia in a northern Han Chinese population. ( 24790447 )
2014
45
Cognitive restructuring and graded behavioural exposure for delusional appraisals of auditory hallucinations and comorbid anxiety in paranoid schizophrenia. ( 25302129 )
2014
46
Subjective experience of emotions and emotional empathy in paranoid schizophrenia. ( 25288043 )
2014
47
TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese. ( 24668623 )
2014
48
Clinico-epidemiological comparison of delusion prominent and hallucination prominent clinical subgroups of paranoid schizophrenia. ( 23518786 )
2013
49
History of Religious Delusions and Psychosocial Functioning Among Mexican Patients with Paranoid Schizophrenia. ( 23674244 )
2013
50
Kallmann syndrome and paranoid schizophrenia: a rare combination. ( 23329708 )
2013

Variations for Paranoid Schizophrenia

Expression for Paranoid Schizophrenia

Search GEO for disease gene expression data for Paranoid Schizophrenia.

Pathways for Paranoid Schizophrenia

GO Terms for Paranoid Schizophrenia

Biological processes related to Paranoid Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 circadian rhythm GO:0007623 9.58 NTRK2 SLC6A4 TPH2
2 long-term synaptic potentiation GO:0060291 9.48 NTRK2 S100B
3 neurotransmitter catabolic process GO:0042135 9.46 COMT MAOA
4 catecholamine metabolic process GO:0006584 9.43 COMT MAOA
5 memory GO:0007613 9.43 HTR2A S100B SLC6A4
6 monoamine transport GO:0015844 9.37 SLC18A1 SLC6A4
7 dopamine catabolic process GO:0042420 9.32 COMT MAOA
8 regulation of hormone secretion GO:0046883 9.16 CCKAR HTR2A
9 brain-derived neurotrophic factor receptor signaling pathway GO:0031547 8.96 BDNF NTRK2
10 serotonin transport GO:0006837 8.62 SLC18A1 SLC6A4

Molecular functions related to Paranoid Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monoamine transmembrane transporter activity GO:0008504 8.96 SLC18A1 SLC6A4
2 serotonin transmembrane transporter activity GO:0015222 8.62 SLC18A1 SLC6A4

Sources for Paranoid Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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