MCID: PRN009
MIFTS: 53

Paranoid Schizophrenia malady

Mental diseases category

Summaries for Paranoid Schizophrenia

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A schizophrenia that involves delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening.

MalaCards: Paranoid Schizophrenia, also known as chronic paranoid schizophrenia, is related to schizophrenia and parkinson's disease. An important gene associated with Paranoid Schizophrenia is COMT (catechol-O-methyltransferase), and among its related pathways are Tyrosine metabolism p.1 dopamine and Phenylalanine metabolism. The drug chlorprothixene and the compounds dopeg and 3-methoxytyramine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Wikipedia:66 Paranoid schizophrenia, also called schizophrenia, paranoid type is a sub-type of schizophrenia as... more...

Aliases & Classifications for Paranoid Schizophrenia

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Sources:
9Disease Ontology, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

paranoid schizophrenia 9 46 63
chronic paranoid schizophrenia 9 63
paranoid type schizophrenia subchronic state 9
paranoid type schizophrenia 9
paraphrenic schizophrenia 9
paraphrenia - late 9


Related Diseases for Paranoid Schizophrenia

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Paranoid Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.9GLS, MAOA, COMT, CCKAR
2parkinson's disease30.4MAOA, COMT
3obsessive-compulsive disorder30.3COMT, MAOA
4psychotic disorder30.3MAOA, COMT
5mood disorder30.3MAOA, COMT
6dementia30.2COMT, MAOA, GLS
7mental retardation30.2COMT, MAOA, ALDH5A1
8delusional disorder10.4
9blindness10.4
10klinefelter's syndrome10.3
11vascular dementia10.1
12narcolepsy10.1
13major depressive disorder10.1
14capgras syndrome10.1
15alexithymia10.1
16priapism10.1
17peripartum cardiomyopathy10.1
18post-traumatic stress disorder10.1
19ulcerative colitis10.1
20mutism10.1
21kallmann syndrome10.1
22graves' disease10.1
23alcohol dependence10.1
24neuroleptic malignant syndrome10.1
25esophagitis10.1
26factitious disorder10.1
27influenza10.1
28personality disorder10.1
29scleroderma10.1
30thyroiditis10.1
31brain injury10.1
32traumatic brain injury10.1
33generalized anxiety disorder10.1MAOA
34antisocial personality disorder10.1MAOA
35social phobia10.1MAOA, COMT
36conduct disorder10.1COMT, MAOA
37bulimia nervosa10.1MAOA, COMT
38gilles de la tourette syndrome10.1MAOA, COMT
39anxiety disorder10.0MAOA, COMT
40attention deficit hyperactivity disorder10.0COMT, MAOA
41hepatic encephalopathy10.0GLS, MAOA
42anorexia nervosa10.0COMT, MAOA
43eating disorder10.0COMT, CCKAR
44migraine10.0MAOA, COMT
45bipolar disorder10.0MAOA, COMT
46pancreatic cancer10.0MAOA, CCKAR
47panic disorder10.0MAOA, COMT, CCKAR
48obesity10.0MAOA, COMT, CCKAR
49alzheimer's disease10.0COMT, MAOA, GLS

Graphical network of the top 20 diseases related to Paranoid Schizophrenia:



Diseases related to paranoid schizophrenia

Symptoms for Paranoid Schizophrenia

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Drugs & Therapeutics for Paranoid Schizophrenia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Paranoid Schizophrenia

Drug clinical trials:

Search ClinicalTrials for Paranoid Schizophrenia

Search NIH Clinical Center for Paranoid Schizophrenia

Search CenterWatch for Paranoid Schizophrenia

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Paranoid Schizophrenia

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Anatomical Context for Paranoid Schizophrenia

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Sources:
34MalaCards
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MalaCards organs/tissues related to Paranoid Schizophrenia:

34
Testes, Brain, Eye, Pituitary, Thyroid, Cortex, Amygdala, Prefrontal cortex

Animal Models for Paranoid Schizophrenia or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Paranoid Schizophrenia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.8CCKAR, COMT, ALDH5A1, FADS2
2MP:00053767.6FADS2, CCKAR, COMT, MAOA, ALDH5A1
3MP:00053867.0MAOA, FADS2, GLS, ALDH5A1, CCKAR, COMT

Publications for Paranoid Schizophrenia

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Sources:
53PubMed
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Articles related to Paranoid Schizophrenia:

(show top 50)    (show all 258)
idTitleAuthorsYear
1
Lack of association of IL-6 (-174 G>C) and TNF-I+ (-238 G>A) variants with paranoid schizophrenia in Indian Bengalee population. (23265967)
2013
2
Abnormal auditory sensory gating-out in first-episode and never-medicated paranoid schizophrenia patients: an fMRI study. (23820976)
2013
3
BDNF val66met polymorphism is associated with age at onset and intensity of symptoms of paranoid schizophrenia in a Polish population. (23487199)
2013
4
Kallmann syndrome and paranoid schizophrenia: a rare combination. (23329708)
2013
5
Capgras delusion in paranoid schizophrenia complicated by vascular dementia. (23037670)
2012
6
Positron emission tomography experience with 2-[A^a8,F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[A^a8,F]FA) in the living human brain of smokers with paranoid schizophrenia. (22169936)
2012
7
Association study of interferon gamma (IFN-I^) +874T/A gene polymorphism in patients with paranoid schizophrenia. (20821074)
2011
8
Different aspects of theory of mind in paranoid schizophrenia: evidence from a video-based assessment. (20947175)
2011
9
Functional polymorphism in the interleukin-6 and interleukin-10 genes in patients with paranoid schizophrenia--a case-control study. (20393813)
2010
10
Sensitization, epileptic-like symptoms and local synchronization in patients with paranoid schizophrenia. (19878702)
2010
11
Olanzapine-induced neuroleptic malignant syndrome in a patient with paranoid schizophrenia. (19067992)
2009
12
The influence of emotion clarity on emotional prosody identification in paranoid schizophrenia. (19000339)
2009
13
Neuropsychological relationships in paranoid schizophrenia with and without delusional misidentification syndromes. A comparative study. (18539375)
2008
14
EEG phase synchronization in patients with paranoid schizophrenia. (18835328)
2008
15
Relationship between cardiovagal modulation and psychotic state in patients with paranoid schizophrenia. (17919737)
2008
16
Prolactin and estradiol serum levels in unmedicated male paranoid schizophrenia patients. (17110010)
2007
17
Functional disintegration in paranoid schizophrenia using resting-state fMRI. (17628434)
2007
18
Aberrantly flattened responsivity to emotional pictures in paranoid schizophrenia. (16884781)
2006
19
Genetic associations between delusional disorder and paranoid schizophrenia: A novel etiologic approach. (16786814)
2006
20
A patient's journey: living with paranoid schizophrenia. (16990323)
2006
21
Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. (14992974)
2004
22
Factor structure of paranoid schizophrenia: a prospective study. (12845284)
2003
23
Anterior cingulate metabolism correlates with stroop errors in paranoid schizophrenia patients. (11377927)
2001
24
Insight in paranoid schizophrenia--its relationship to psychopathology and premorbid adjustment. (9777276)
1998
25
Sex-specific expression of Heschl's gyrus functional and structural abnormalities in paranoid schizophrenia. (9396942)
1997
26
Conjugate lateral eye movements during exacerbation of paranoid schizophrenia and the acute episode of major depression. (9129787)
1997
27
Maintenance ECT for treatment of therapy-resistant paranoid schizophrenia and Parkinson's disease. (7548464)
1995
28
The Capgras syndrome in paranoid schizophrenia. (1448540)
1992
29
Wisconsin Card Sorting Test deficits in chronic paranoid schizophrenia. Evidence for a relatively discrete subgroup? (1515378)
1992
30
Paranoid schizophrenia: prognosis under DSM-II and DSM-III-R. (2731425)
1989
31
A three-year prospective follow-up of psychopathology and social reintegration in paranoid schizophrenia in relation to age at onset. (3399822)
1988
32
Motor and sighting dominance in schizophrenia and affective disorder. Evidence for right-hand grip strength prominence in paranoid schizophrenia and bipolar illness. (4016461)
1985
33
Is loxapine more effective than chlorpromazine in paranoid schizophrenia? (6388362)
1984
34
Illusory correlations in paranoid and non-paranoid schizophrenia. (6487859)
1984
35
Post-traumatic stress disorder masquerading as paranoid schizophrenia: case report. (6817230)
1982
36
Cross-cultural study of a biochemical abnormality in paranoid schizophrenia. (6948314)
1981
37
Paranoid schizophrenia and platelet MAO activity. (7435694)
1980
38
Possible implication of an inosinetriphosphate metabolic error and glutamic acid decarboxylase in paranoid schizophrenia. (110320)
1979
39
Manic-depressive illness or paranoid schizophrenia? (290045)
1979
40
Split decision: critique of complete audit of paranoid schizophrenia. (103052)
1978
41
Nursing care study. Paranoid schizophrenia: learning to cope with eccentricity. (252023)
1978
42
Iowa 500: the clinical and genetic distinction of hebephrenic and paranoid schizophrenia. (4835424)
1974
43
PARANOID SCHIZOPHRENIA IN A PATIENT WITH KLINEFELTER'S SYNDROME. (14220862)
1964
44
The Rorschach "eyes' hypothesis and paranoid schizophrenia. (13887991)
1962
45
A double-blind trial to investigate the effects of Thorazine (Largactil, chlorpromazine), Compazine (Stemetil, prochlorperazine) and Stelazine (trifluoperazine) in paranoid schizophrenia. (13785665)
1961
46
A short scale for rating paranoid schizophrenia. (13841648)
1959
47
Clinical aspects of paraphrenic (delusional paranoid) schizophrenia]. (13605174)
1958
48
Prognosis in paranoid schizophrenia on the basis of the Rorschach. (13061662)
1953
49
A dynamic factor correlated with the prognosis in paranoid schizophrenia. (14818482)
1951
50
The place of paranoid states in psychiatric classification with special reference to paranoid schizophrenia. (18875667)
1948

Variations for Paranoid Schizophrenia

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Expression for genes affiliated with Paranoid Schizophrenia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paranoid Schizophrenia

Search GEO for disease gene expression data for Paranoid Schizophrenia.

Pathways for genes affiliated with Paranoid Schizophrenia

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Sources:
51PathCards, 61Thomson Reuters, 31KEGG, 39NCBI BioSystems Database, 56Reactome
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Pathways related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MAOA, COMT
2
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
9.6COMT, MAOA
3
Show member pathways
catecholamine biosynthesis39
9.6COMT, MAOA
49.6COMT, MAOA
59.6COMT, MAOA
6
Show member pathways
9.6MAOA, COMT
7
Show member pathways
citrulline-nitric oxide cycle39
arginine degradation I (arginase pathway)39
proline degradation39
glutamine degradation I39
proline biosynthesis I39
superpathway of citrulline metabolism39
proline biosynthesis II (from arginine)39
citrulline biosynthesis39
arginine degradation VI (arginase 2 pathway)39
Urea cycle and metabolism of amino groups39
asparagine biosynthesis I39
4-hydroxyproline degradation I39
citrulline degradation39
9.5MAOA, GLS
89.4ALDH5A1, GLS
9
Show member pathways
9.1COMT, MAOA, GLS
10
Show member pathways
9.0GLS, ALDH5A1, MAOA
11
Show member pathways
8.6COMT, MAOA, ALDH5A1, GLS
12
Show member pathways
7.7MAOA, COMT, FADS2, ALDH5A1, GLS

Compounds for genes affiliated with Paranoid Schizophrenia

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR
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Compounds related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1dopeg4610.0MAOA, COMT
23-methoxytyramine46 2511.0COMT, MAOA
3nialamide46 1211.0COMT, MAOA
4normetanephrine46 2511.0COMT, MAOA
5metanephrine46 2511.0COMT, MAOA
6dopac4610.0MAOA, COMT
7mhpg4610.0COMT, MAOA
8methylphenidate46 52 1212.0COMT, MAOA
9maoa4610.0COMT, MAOA
10homovanillic acid46 2511.0COMT, MAOA
11fluvoxamine46 52 1212.0COMT, MAOA
12tyramine46 30 2512.0COMT, MAOA
13selegiline46 1211.0MAOA, COMT
14paroxetine46 52 30 1213.0COMT, MAOA
15methamphetamine46 52 1211.9COMT, MAOA
166-hydroxydopamine469.9MAOA, COMT
17mptp469.9COMT, MAOA
18levodopa46 1210.9MAOA, COMT
19pyridoxal 5-phosphate469.8COMT, GLS
20Ammonia259.8MAOA, GLS
21amine469.8COMT, MAOA
22benzodiazepines469.8MAOA, CCKAR
23vitamin b6469.8GLS, ALDH5A1
24benzodiazepine469.8MAOA, CCKAR
25catecholamine469.8COMT, MAOA
26succinate469.8MAOA, ALDH5A1
27n-ethylmaleimide46 1210.7MAOA, GLS
28alpha-ketoglutarate469.7ALDH5A1, GLS
29carbon469.6MAOA, COMT
30nad+469.6ALDH5A1, GLS
31morphine46 52 30 1212.5CCKAR, COMT
32choline46 25 1211.5GLS, MAOA, COMT
33nmda46 3010.4GLS, MAOA, COMT
34cocaine46 1210.3CCKAR, COMT
35dopamine46 30 25 1212.3COMT, MAOA, CCKAR
365-hydroxytryptamine469.3COMT, MAOA
37glutamine469.1CCKAR, ALDH5A1, GLS
38Water259.1GLS, ALDH5A1, MAOA
39glutamate469.0COMT, MAOA, ALDH5A1, GLS
40alanine468.8CCKAR, ALDH5A1, GLS
41gaba468.8MAOA, ALDH5A1, GLS, CCKAR

GO Terms for genes affiliated with Paranoid Schizophrenia

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Sources:
17Gene Ontology
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Cellular components related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:0057398.6GLS, ALDH5A1, MAOA, COMT

Biological processes related to Paranoid Schizophrenia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:0424209.7MAOA, COMT
2neurotransmitter biosynthetic processGO:0421369.6MAOA, COMT
3xenobiotic metabolic processGO:0068059.6COMT, MAOA
4neurotransmitter catabolic processGO:0421359.3COMT, MAOA, ALDH5A1
5protein homotetramerizationGO:0512899.1GLS, ALDH5A1
6neurotransmitter secretionGO:0072699.1MAOA, GLS, ALDH5A1
7synaptic transmissionGO:0072688.7ALDH5A1, GLS, COMT, MAOA
8small molecule metabolic processGO:0442818.2MAOA, GLS, FADS2, COMT

Products for genes affiliated with Paranoid Schizophrenia

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Sources for Paranoid Schizophrenia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet