Aliases & Classifications for Paraplegia

MalaCards integrated aliases for Paraplegia:

Name: Paraplegia 12 50 42 14 69
Severe or Complete Loss of Motor Function in the Lower Extremities and Lower Portions of the Trunk 50
Paraplegia, Lower 12

Classifications:



External Ids:

Disease Ontology 12 DOID:607
ICD10 33 G82.2 G82.20
ICD9CM 35 344.1
MeSH 42 D010264
NCIt 47 C50687
SNOMED-CT 64 155031004 60389000
UMLS 69 C0030486

Summaries for Paraplegia

MalaCards based summary : Paraplegia, also known as severe or complete loss of motor function in the lower extremities and lower portions of the trunk, is related to spastic paraplegia 47, autosomal recessive and spastic paraplegia 44, autosomal recessive, and has symptoms including hemiplegia, ophthalmoplegia and paraparesis. An important gene associated with Paraplegia is SPG7 (SPG7, Paraplegin Matrix AAA Peptidase Subunit), and among its related pathways/superpathways is Endocytosis. The drugs Acetazolamide and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 72 Paraplegia is an impairment in motor or sensory function of the lower extremities. The word comes from... more...

Related Diseases for Paraplegia

Diseases related to Paraplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 473)
id Related Disease Score Top Affiliating Genes
1 spastic paraplegia 47, autosomal recessive 33.9 REEP1 WASHC5
2 spastic paraplegia 44, autosomal recessive 33.8 SPG21 ZFYVE27
3 spastic paraplegia 13 33.2 KIF1A SPAST SPG11
4 spastic paraplegia 31, autosomal dominant 33.0 ATL1 REEP1 RTN2 SPAST ZFYVE27
5 hereditary spastic paraplegia 62 32.2 ATL1 NIPA1 REEP1 RTN2 SPAST SPG11
6 spastic paraplegia 4, autosomal dominant 31.7 ATL1 NIPA1 REEP1 RTN2 SLC33A1 SPAST
7 leukodystrophy, hypomyelinating, 4 31.4 ATL1 HSPD1 SPAST WASHC5
8 spastic ataxia 3, autosomal recessive 30.0 HSPD1 PLP1
9 hereditary spastic paraplegia 12.3
10 spastic paraplegia 7, autosomal recessive 12.2
11 spastic paraplegia 2, x-linked 12.2
12 silver spastic paraplegia syndrome 12.2
13 spastic paraplegia 11 12.1
14 spastic paraplegia 23 12.1
15 spastic paraplegia 4 12.1
16 spastic paraplegia 11, autosomal recessive 12.1
17 spastic paraplegia, optic atrophy, and neuropathy 12.1
18 spastic paraplegia 49, autosomal recessive 12.1
19 spastic paraplegia 39, autosomal recessive 12.1
20 spastic paraplegia 15, autosomal recessive 12.1
21 spastic paraplegia 72, autosomal recessive 12.1
22 spastic paraplegia 5a, autosomal recessive 12.1
23 spastic paraplegia 6, autosomal dominant 12.1
24 spastic paraplegia 54, autosomal recessive 12.1
25 spastic paraplegia 8 12.1
26 spastic paraplegia 35, autosomal recessive 12.1
27 spastic paraplegia 10, autosomal dominant 12.1
28 spastic paraplegia 45, autosomal recessive 12.1
29 spastic paraplegia 30, autosomal recessive 12.1
30 spastic paraplegia 56, autosomal recessive 12.1
31 spastic paraplegia 46, autosomal recessive 12.1
32 spastic paraplegia 28, autosomal recessive 12.1
33 spastic paraplegia 43, autosomal recessive 12.1
34 spastic paraplegia 3a 12.1
35 spastic paraplegia 9a, autosomal dominant 12.1
36 spastic paraplegia 18, autosomal recessive 12.1
37 spastic paraplegia 8, autosomal dominant 12.1
38 spastic paraplegia 26, autosomal recessive 12.1
39 spastic paraplegia 61, autosomal recessive 12.1
40 spastic paraplegia 12, autosomal dominant 12.1
41 spastic paraplegia 57, autosomal recessive 12.0
42 spastic paraplegia 42, autosomal dominant 12.0
43 spastic paraplegia 48, autosomal recessive 12.0
44 spastic paraplegia 55, autosomal recessive 12.0
45 troyer syndrome 12.0
46 spastic paraplegia 9b, autosomal recessive 12.0
47 spastic paraplegia 75, autosomal recessive 12.0
48 spastic paraplegia 63 12.0
49 spastic paraplegia 53, autosomal recessive 12.0
50 spastic paraplegia 77, autosomal recessive 12.0

Comorbidity relations with Paraplegia via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Hypertension, Essential Multiple Sclerosis, Disease Progression, Modifier of
Neurogenic Bladder Osteoporosis
Paralytic Ileus Prostate Cancer
Protein-Energy Malnutrition Spinal Cord Disease
Vascular Myelopathy

Graphical network of the top 20 diseases related to Paraplegia:



Diseases related to Paraplegia

Symptoms & Phenotypes for Paraplegia

UMLS symptoms related to Paraplegia:


hemiplegia, ophthalmoplegia, paraparesis, paraplegia, ataxic, monoparesis, paraplegia, cerebral, paraplegia, spinal, monoplegia of lower limb affecting unspecified side, paraplegia, flaccid

MGI Mouse Phenotypes related to Paraplegia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.77 ATL1 DDHD2 HSPD1 KIF1A KIF5A PLP1
2 nervous system MP:0003631 9.4 PLP1 PNPLA6 REEP1 SLC33A1 SPAST SPG11

Drugs & Therapeutics for Paraplegia

Drugs for Paraplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
2 Anticonvulsants Phase 4
3 Carbonic Anhydrase Inhibitors Phase 4
4 diuretics Phase 4
5 Natriuretic Agents Phase 4
6
Minocycline Approved, Investigational Phase 2, Phase 3 10118-90-8 5281021
7
Acetylcholine Approved Phase 2, Phase 3 51-84-3 187
8
Fenofibrate Approved Phase 2, Phase 3 49562-28-9 3339
9 Cortivazol Investigational Phase 3 1110-40-3
10 Anti-Bacterial Agents Phase 2, Phase 3
11 Anti-Infective Agents Phase 2, Phase 3
12 Anti-Inflammatory Agents Phase 3,Phase 2
13 Botulinum Toxins Phase 2, Phase 3
14 Cholinergic Agents Phase 2, Phase 3
15 Neurotransmitter Agents Phase 2, Phase 3,Phase 1
16 Fibrin Tissue Adhesive Phase 2, Phase 3,Phase 1
17 Antimetabolites Phase 2, Phase 3
18 Hypolipidemic Agents Phase 2, Phase 3
19 Lipid Regulating Agents Phase 2, Phase 3
20
Buspirone Approved, Investigational Phase 1, Phase 2 36505-84-7 2477
21
Carbidopa Approved Phase 1, Phase 2 28860-95-9 34359 38101
22
Dopamine Approved Phase 1, Phase 2 51-61-6, 62-31-7 681
23
Levodopa Approved Phase 1, Phase 2 59-92-7 6047
24
chenodeoxycholic acid Approved Phase 2 474-25-9 10133
25
Resveratrol Experimental, Investigational Phase 2 501-36-0 445154
26 abobotulinumtoxinA Phase 2
27 Botulinum Toxins, Type A Phase 2
28 Hemagglutinins Phase 2
29 incobotulinumtoxinA Phase 2
30 Neuromuscular Agents Phase 2
31 onabotulinumtoxinA Phase 2
32 Peripheral Nervous System Agents Phase 2
33 Pharmaceutical Solutions Phase 2
34 Anti-Anxiety Agents Phase 1, Phase 2
35 Antiparkinson Agents Phase 1, Phase 2
36 Carbidopa, levodopa drug combination Phase 1, Phase 2
37 Central Nervous System Depressants Phase 1, Phase 2
38 Dopamine Agents Phase 1, Phase 2
39 Psychotropic Drugs Phase 1, Phase 2
40
Serotonin Phase 1, Phase 2 50-67-9 5202
41 Serotonin Agents Phase 1, Phase 2
42 Tranquilizing Agents Phase 1, Phase 2
43 Analgesics Phase 2
44 Analgesics, Non-Narcotic Phase 2
45 Anticholesteremic Agents Phase 2
46 Anti-Inflammatory Agents, Non-Steroidal Phase 2
47 Antineoplastic Agents, Phytogenic Phase 2
48 Antioxidants Phase 2
49 Antirheumatic Agents Phase 2
50 Atorvastatin Calcium Phase 2 134523-03-8

Interventional clinical trials:

(show top 50) (show all 100)

id Name Status NCT ID Phase Drugs
1 Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery Unknown status NCT01889498 Phase 4 Acetazolamide
2 Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions Completed NCT01208584 Phase 4
3 Effect of Heat Exposure on Cognition in Persons With Tetraplegia Recruiting NCT02488824 Phase 4
4 Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement Unknown status NCT01813240 Phase 2, Phase 3 Minocycline;placebo
5 Comparison of a Cortivazol (ALTIM®) Infiltration of Posterior Epidural Space at L3-L4 Stage Versus an Epidural Infiltration of Cortivazol (ALTIM®) on Contact With Disco Radicular Conflict in Discal Sciatica Unknown status NCT02151045 Phase 3
6 Retraining Walking After Spinal Cord Injury Unknown status NCT00059553 Phase 2, Phase 3
7 Fenofibrate Treatment in SCI Recruiting NCT02455336 Phase 2, Phase 3 Fenofibrate
8 Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia Active, not recruiting NCT02604186 Phase 2, Phase 3
9 Study of the Impact of the Use of a Corset on the Respiratory Function of Patients With Spinal Cord Injury Withdrawn NCT01569360 Phase 3
10 Cethrin in Acute Cervical Spinal Cord Injury Withdrawn NCT02053883 Phase 2, Phase 3 Cethrin (BA-210);Placebo
11 Spinal Cord Injury Leg Rehabilitation Completed NCT01498991 Phase 1, Phase 2
12 Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral Palsy Completed NCT02188277 Phase 2 Xeomin;Botox®
13 The Effects of Passive Gait Training in Complete Motor Spinal Cord Injury (SCI) Completed NCT01349478 Phase 1, Phase 2
14 A Safety Study for Cethrin (BA-210) in the Treatment of Acute Thoracic and Cervical Spinal Cord Injuries Completed NCT00500812 Phase 1, Phase 2 Cethrin
15 Study to Assess Safety, Tolerability and MTD of a Central Pattern Generator-activating Tritherapy (SPINALON) in Patients With Chronic Spinal Cord Injury Completed NCT01484184 Phase 1, Phase 2 SPINALON (buspirone + levodopa + cardidopa)
16 Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5 Active, not recruiting NCT02314208 Phase 2 Xenbilox;Tahor
17 Neural Stem Cell Transplantation in Traumatic Spinal Cord Injury Active, not recruiting NCT02326662 Phase 1, Phase 2
18 Autologous Mesenchymal Stem Cells Transplantation in Thoracolumbar Chronic and Complete Spinal Cord Injury Spinal Cord Injury Not yet recruiting NCT02574585 Phase 2
19 Autologous Incubated Macrophages for Patients With Complete Spinal Cord Injuries Suspended NCT00073853 Phase 2
20 Pressure Ulcer Formation Prevention in Paraplegics Using Computer and Sensory Substitution Via the Tongue. Terminated NCT00429013 Phase 2
21 The ReWalk Exoskeletal Walking System for Persons With Paraplegia Unknown status NCT01454570 Phase 1
22 SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias Unknown status NCT00140829 Phase 1
23 Natural History, Genetic Bases and Phenotype-genotype Correlations in Autosomal Dominant Spinocerebellar Degenerations Unknown status NCT00136630 Phase 1
24 Orthostatic Tolerance During FES (Functional Electrical Stimulation)-Walking in Paraplegia Completed NCT00108043 Phase 1
25 Safety of Autologous Human Schwann Cells (ahSC) in Subjects With Subacute SCI Completed NCT01739023 Phase 1
26 Use of Interactive Gaming for Enhanced Function After Spinal Cord Injury Completed NCT01537978 Phase 1
27 Safety Study of Local Administration of Autologous Bone Marrow Stromal Cells in Chronic Paraplegia Completed NCT01909154 Phase 1
28 The Safety of ahSC in Chronic SCI With Rehabilitation Recruiting NCT02354625 Phase 1
29 Improving Ambulatory Community Access After Paralysis Active, not recruiting NCT01570816 Phase 1
30 Cohorts and Collections: Clinical and Genetic Study of Parkinson's Disease and Epilepsies Terminated NCT00142363 Phase 1
31 Evaluation of a Hybrid Prototype Strategy (Electrostimulation of Lower Limb Muscles Associated With Voluntary Strengthening of the Upper Limbs) in Reconditioning to Effort in Patients With Chronic Paraplegia. Unknown status NCT02042508
32 Reciprocating Gait Orthoses for Paraplegia Patients Unknown status NCT02227407
33 Adjusting Wheelchair Set-Up to Minimize Shoulder Joint Forces During Propulsion Unknown status NCT00785278
34 Home/Work, Community Mobility Skills in the ReWalk Exoskeleton in Persons With SCI Unknown status NCT02118194
35 Abdominal Functional Electrical Stimulation in Tetraplegia Unknown status NCT00202631
36 Effect of Intense Multi-modal Training on Bone Health and Quality of Life in Persons With Spinal Cord Injury Unknown status NCT01386762 Early Phase 1
37 Body Composition Assessment in Spinal Cord Injury Unknown status NCT00957762
38 Genetic and Morphological Analysis of Thyrotoxic Periodic Paralysis Unknown status NCT02287363
39 Paraplegic Cycling: Improving Health After Spinal Cord Injury Unknown status NCT00204100
40 Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis Completed NCT00023075
41 Safety and Tolerance of Local Heat Application in the Paralyzed Area of Patients With Complete Paraplegia Completed NCT03001531
42 Effects of Exercise in People With Paraplegia Completed NCT01203150
43 Efficacy of Nebido on Bone Mineral Density (BMD) in Hypogonadal Paraplegic Patients With Confirmed Osteoporosis Completed NCT00838838 Testosterone Undeconate (Nebido-R, BAY86-5037)
44 A Study Testing Safety and Tolerance of the ReWalk Exoskeleton Suit Completed NCT00627107
45 Safety and Performance Evaluation of ReWalk Reciprocating Gait Orthosis (RGO) Completed NCT01251549
46 Exercise to Reduce Obesity in Spinal Cord Injury Completed NCT00270855
47 Robotically Assisted Treadmill Training in Spinal Cord Injury (SCI) Completed NCT00385918
48 Finding the Optimal Voluntary Exercise Parameters for Those Living With Quadriplegia Completed NCT03146728
49 Medico-economical Impact of the Brindley Neurosurgical Technique in France Completed NCT00221767
50 Study of an Implantable Functional Neuromuscular Stimulation System for Patients With Spinal Cord Injuries Completed NCT00004445

Search NIH Clinical Center for Paraplegia

Cochrane evidence based reviews: paraplegia

Genetic Tests for Paraplegia

Anatomical Context for Paraplegia

MalaCards organs/tissues related to Paraplegia:

39
Spinal Cord, Brain, Bone, Testes, Bone Marrow, Colon, Tongue

Publications for Paraplegia

Articles related to Paraplegia:

(show top 50) (show all 1294)
id Title Authors Year
1
Effect of exoskeletal joint constraint and passive resistance on metabolic energy expenditure: Implications for walking in paraplegia. ( 28817701 )
2017
2
Considering Spastic Paraplegia Type 7 and Adult-Onset Alexander Disease. ( 28459923 )
2017
3
Effects of resistance-guided high intensity interval functional electrical stimulation cycling on an individual with paraplegia: A case report. ( 28868988 )
2017
4
Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2. ( 28836307 )
2017
5
SPG20 mutation in three siblings with familial hereditary spastic paraplegia. ( 28679690 )
2017
6
Long-term performance and user satisfaction with implanted neuroprostheses for upright mobility after paraplegia: Two to 14-year follow-up. ( 28899825 )
2017
7
TFG associated hereditary spastic paraplegia: an addition to the phenotypic spectrum. ( 28124177 )
2017
8
Febrile ataxia and myokymia broaden the SPG26 hereditary spastic paraplegia phenotype. ( 28626794 )
2017
9
Identification of novel SPG11 mutations in a cohort of Chinese families with hereditary spastic paraplegia. ( 28933964 )
2017
10
Progressive hereditary spastic paraplegia caused by a homozygous KY mutation. ( 28488683 )
2017
11
ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia. ( 28158749 )
2017
12
Active lower limb orthosis with one degree of freedom for people with paraplegia. ( 28813828 )
2017
13
PLA2G6 mutations associated with a continuous clinical spectrum from neuroaxonal dystrophy to hereditary spastic paraplegia. ( 28295203 )
2017
14
Delayed leg paraplegia associated with hyperextension injury in patients with diffuse idiopathic skeletal hyperostosis (DISH): case report and review of the literature. ( 28458848 )
2017
15
De novo REEP2 missense mutation in pure hereditary spastic paraplegia. ( 28491902 )
2017
16
Novel UBQLN2 mutations linked to amyotrophic lateral sclerosis and atypical hereditary spastic paraplegia phenotype through defective HSP70-mediated proteolysis. ( 28716533 )
2017
17
Targeted high throughput sequencing in hereditary ataxia and spastic paraplegia. ( 28362824 )
2017
18
Rapid Recovery from Paraplegia in a Patient with Foix-Alajouanine Syndrome. ( 27794514 )
2017
19
ALS and MMN mimics in patients with BSCL2 mutations: the expanding clinical spectrum of SPG17 hereditary spastic paraplegia. ( 27738760 )
2017
20
Successful spinal cord stimulation for neuropathic below-level spinal cord injury pain following complete paraplegia: a case report. ( 28808583 )
2017
21
Beneficial effects of rapamycin in a Drosophila model for hereditary spastic paraplegia. ( 27909242 )
2017
22
Spastic paraplegia type 4: A novel SPAST splice site donor mutation and expansion of the phenotype variability. ( 28870597 )
2017
23
Energy balance components in persons with paraplegia: daily variation and appropriate measurement duration. ( 28950900 )
2017
24
Author response: Clinical Reasoning: A young woman with respiratory failure, hearing loss, and paraplegia. ( 28847836 )
2017
25
Structural annotation of Beta-1,4-N-acetyl galactosaminyltransferase 1 (B4GALNT1) causing Hereditary Spastic Paraplegia 26. ( 28536081 )
2017
26
Expert's comment concerning Grand Rounds case entitled "Acute complete paraplegia of a 8-year-old girl caused by spinal cord infarction following minor trauma complicated with longitudinal signal change of spinal cord" by K. Nagata et al. (Eur Spine J, 2017: doi:10.1007/s00586-017-4995-9). ( 28409289 )
2017
27
Novel mutations c. [453dupA] + [663G > A] of the SPG11 gene associated with hereditary spastic paraplegia with a thin corpus callosum. ( 28681766 )
2017
28
Epidural Haematoma Causing Paraplegia in a Patient with Ankylosing Spondylitis: A Case Report. ( 28824860 )
2017
29
Acute complete paraplegia of 8-year-old girl caused by spinal cord infarction following minor trauma complicated with longitudinal signal change of spinal cord. ( 28281001 )
2017
30
Paraplegia in Subarachnoid Hemorrhage Complicated With Coarctation of Aorta: An Unusual Complication. ( 28816884 )
2017
31
Letter re: Clinical Reasoning: A young woman with respiratory failure, hearing loss, and paraplegia. ( 28847833 )
2017
32
Sequential bilateral complete rupture of the rectus femoris muscle in a patient with hereditary spastic paraplegia. ( 28264543 )
2017
33
Pathophysiology, diagnostic work-up and management of balance impairments and falls in patients with hereditary spastic paraplegia. ( 28471471 )
2017
34
Cannabinoids for spasticity due to multiple sclerosis or paraplegia: A systematic review and meta-analysis of randomized clinical trials. ( 28917371 )
2017
35
Hypertension, acute stent thrombosis and paraplegia 6 months after TEVAR for blunt thoracic aortic injury in a 22 year old patient. ( 28893706 )
2017
36
Clinical and genetic study of hereditary spastic paraplegia in Canada. ( 27957547 )
2017
37
A Case of Acute Paraplegia Due to Aortic Dissection in Marfan Syndrome. ( 28479826 )
2017
38
Disease-Causing Variants in the ATL1 Gene Are a Rare Cause of Hereditary Spastic Paraplegia among Czech Patients. ( 28736820 )
2017
39
Clinical exome sequencing for cerebellar ataxia and spastic paraplegia uncovers novel gene-disease associations and unanticipated rare disorders. ( 28179632 )
2017
40
Novel homozygous missense mutation in NT5C2 underlying hereditary spastic paraplegia SPG45. ( 28884889 )
2017
41
A novel mutation in KIF5A in a Malian family with spastic paraplegia and sensory loss. ( 28382308 )
2017
42
Posterior-only vertebral column resection for revision surgery in post-laminectomy rotokyphoscoliosis associated with late-onset paraplegia: A case report and literature review. ( 28072705 )
2017
43
Incomplete paraplegia caused by extramedullary hematopoiesis in a patient with thalassemia intermedia. ( 28503326 )
2017
44
Studies on truncating mutations of SPAST associated with Hereditary Spastic Paraplegia indicate greater accumulation and toxicity of the M1 isoform of spastin. ( 28495799 )
2017
45
New genetic causes for complex hereditary spastic paraplegia. ( 28716262 )
2017
46
A new phenotype associated with homozygous GRN mutations: complicated spastic paraplegia. ( 28000352 )
2017
47
Considering Spastic Paraplegia Type 7 and Adult-Onset Alexander Disease-Reply. ( 28459933 )
2017
48
Characterization of kinesin switch I mutations that cause hereditary spastic paraplegia. ( 28678816 )
2017
49
First patient with hereditary spastic paraplegia type 8 in Poland. ( 28878906 )
2017
50
Exome sequencing reveals two FA2H mutations in a family with a complicated form of Hereditary Spastic Paraplegia and psychiatric impairments. ( 28017243 )
2017

Variations for Paraplegia

Copy number variations for Paraplegia from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 170541 3 155544315 155572167 Copy number SLC33A1 Paraplegias

Expression for Paraplegia

Search GEO for disease gene expression data for Paraplegia.

Pathways for Paraplegia

Pathways related to Paraplegia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.44 KIF5A SPART SPG21 WASHC5 ZFYVE27

GO Terms for Paraplegia

Cellular components related to Paraplegia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.81 ATL1 CYP7B1 PNPLA6 REEP1 RTN2 SLC33A1
2 axon GO:0030424 9.62 ATL1 KIF1A SPG11 ZFYVE27
3 endoplasmic reticulum membrane GO:0005789 9.56 ATL1 CYP7B1 PNPLA6 REEP1 RTN2 SLC33A1
4 axon cytoplasm GO:1904115 9.43 KIF1A SPAST SPG7
5 midbody GO:0030496 9.4 SPAST ZFYVE26
6 endoplasmic reticulum tubular network GO:0071782 8.8 ATL1 REEP1 ZFYVE27
7 membrane GO:0016020 10.24 ATL1 CYP7B1 DDHD2 HSPD1 KIF5A NIPA1

Biological processes related to Paraplegia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 anterograde axonal transport GO:0008089 8.8 KIF1A SPAST SPG7
2 lipid particle organization GO:0034389 8.65 DDHD2

Molecular functions related to Paraplegia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 microtubule binding GO:0008017 8.92 KIF1A KIF5A REEP1 SPAST

Sources for Paraplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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