MCID: PRP016
MIFTS: 48

Paraplegia malady

Neuronal diseases category

Summaries for Paraplegia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Paraplegia is an impairment in motor or sensory function of the lower extremities. The word comes from... more...

MalaCards: Paraplegia, also known as severe or complete loss of motor function in the lower extremities and lower portions of the trunk, is related to hereditary spastic paraplegia and spastic paraplegia 3a. An important gene associated with Paraplegia is SPAST (spastin). Affiliated tissues include spinal cord, bone and heart, and related mouse phenotype behavior/neurological.

Aliases & Classifications for Paraplegia

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

paraplegia 8 42 10 60
severe or complete loss of motor function in the lower extremities and lower portions of the trunk 42
paraplegia, lower 8


External Ids:

Disease Ontology8 DOID:607
ICD9CM27 344.1
MeSH34 D010264
SNOMED-CT56 60389000, 155031004
NCIt39 C50687
ICD1025 G82.2

Related Diseases for Paraplegia

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17GeneCards, 18GeneDecks
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Diseases related to Paraplegia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 346)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary spastic paraplegia31.6SPAST, SPG7, SPG20, KIF5A, HSPD1, NIPA1
2spastic paraplegia 3a30.7SPAST, ATL1
3intellectual disability29.9L1CAM
4multiple sclerosis29.8HSPD1, PLP1
5opa3-related 3-methylglutaconic aciduria29.6SPG7
6motor neuron disease29.6SPAST
7spastic paraplegia 1110.5
8spastic paraplegia 410.5
9neuropathy10.5
10spastic paraplegia 710.5
11spastic paraplegia 810.5
12aortic aneurysm10.4
13spastic paraplegia 1710.4
14spastic paraplegia 210.4
15quadriplegia10.4
16ischemia10.3
17troyer syndrome10.3
18spastic paraplegia 1510.3
19thoracic aortic aneurysm10.3
20spinal cord ischemia10.3
21neuronitis10.3
22spastic paraplegia 39, autosomal recessive10.3
23optic atrophy10.2
24spastic paraplegia 2310.2
25spastic paraplegia with precocious puberty10.2
26spastic paraplegia 3110.2
27spastic paraplegia 3a, autosomal dominant10.2
28axonal neuropathy10.2
29hereditary sensory neuropathy10.2
30hereditary ataxia10.2
31spastic paraplegia 110.2
32spastic paraplegia neuropathy poikiloderma10.2
33spastic paraplegia 5a, autosomal recessive10.2
34pelizaeus-merzbacher disease10.2
35spastic paraplegia 5a10.2
36spastic paraplegia 25, autosomal recessive10.2
37spastic paraplegia 15, autosomal recessive10.2
38spastic paraplegia 49, autosomal recessive10.2
39spastic paraplegia 7, autosomal recessive10.2
40spastic paraplegia 2, x-linked10.2
41x-linked spastic paraplegia type 1610.2
42arteriovenous fistula10.1
43myelitis10.1
44cerebritis10.1
45cervicitis10.1
46fatty acid hydroxylase-associated neurodegeneration10.1
47spastic paraplegia 1010.1
48spastic paraplegia 610.1
49spastic paraplegia 30, autosomal recessive10.1
50spastic paraplegia 14, autosomal recessive10.1

Graphical network of the top 20 diseases related to Paraplegia:



Diseases related to paraplegia

Clinical Features for Paraplegia

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Drugs & Therapeutics for Paraplegia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Paraplegia

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Anatomical Context for Paraplegia

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32MalaCards
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MalaCards organs/tissues related to Paraplegia:

32
Spinal cord, Bone, Heart, Thyroid, Testes, Brain, Bone marrow, B lymphoblasts, Prostate, Pancreas, Pituitary, B cells, T cells, Testis, Breast, Skeletal muscle, Lung, Cerebellum, Temporal lobe

Animal Models for Paraplegia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Paraplegia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.8SPAST, SPG7, SPG20, KIF5A, KIF1A, PLP1

Publications for Paraplegia

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50PubMed
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Articles related to Paraplegia:

(show top 50)    (show all 999)
idTitleAuthorsYear
1
Vertical ground reaction force-based analysis of powered exoskeleton-assisted walking in persons with motor-complete paraplegia. (23820147)
2013
2
Thoracic vertebral hemangioma causing paraplegia in Klippel-Trenaunay-Weber syndrome: case report. (24101274)
2013
3
SPG3A-linked hereditary spastic paraplegia associated with cerebral glucose hypometabolism. (23233086)
2013
4
Regarding "Low incidence of paraplegia after thoracic endovascular aneurysm repair with proactive spinal cord protective protocols". (23972252)
2013
5
Isolated intraspinal juvenile xanthogranuloma in an infant presenting as acute paraplegia. (23254572)
2013
6
Post-myelography paraplegia in a woman with thoracic stenosis. (23809597)
2013
7
Paraplegia after epidural anaesthesia. (23487803)
2013
8
Novel B4GALNT1 mutations in a complicated form of hereditary spastic paraplegia. (24283893)
2013
9
Mechanisms of postural instability in hereditary spastic paraplegia. (23784609)
2013
10
Pott's paraplegia secondary to Scrofuloderma is a rare association. (24042993)
2013
11
How "healthy" is circuit resistance training following paraplegia? Kinematic analysis associated with shoulder mechanical impingement risk. (24030158)
2013
12
Tract-based spatial statistics of diffusion tensor imaging in hereditary spastic paraplegia with thin corpus callosum reveals widespread white matter changes. (23302284)
2013
13
Low incidence of paraplegia after thoracic endovascular aneurysm repair with proactive spinal cord protective protocols. (23490292)
2013
14
Hereditary spastic paraplegia caused by a mutation in the VCP gene. (22991237)
2012
15
Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia. (22392442)
2012
16
A Method for the Autonomous Control of Lower Limb Exo-skeletons for Persons with Paraplegia. (23505407)
2012
17
Reduced perceptual sensitivity for biological motion in paraplegia patients. (22115454)
2011
18
A novel factor XII mutation, FXII R84P, causing factor XII deficiency in a patient with hereditary spastic paraplegia. (21297451)
2011
19
The patient with acute paraplegia: a problem-based review. (21573266)
2011
20
Hereditary spastic paraplegia associated with axonal neuropathy: a novel mutation of SPG3A in a large family. (21321493)
2011
21
Adaptor protein complex 4 deficiency causes severe autosomal- recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature. (21620353)
2011
22
Rapid ischemic preconditioning with a short reperfusion time prevents delayed paraplegia in a rabbit model. (21997656)
2011
23
Gait evaluation of a novel hip constraint orthosis with implication for walking in paraplegia. (20378478)
2010
24
Experimental two-stage simulated repair of extensive thoracoabdominal aneurysms reduces paraplegia risk. (20732484)
2010
25
Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice. (20393889)
2010
26
Effects of paraplegia on cardiac autonomic regulation during static exercise. (20855982)
2010
27
Hereditary spastic paraplegia: identification of an SPG3A gene mutation in a Chinese family. (19652243)
2009
28
A modern theory of paraplegia in the treatment of aneurysms of the thoracoabdominal aorta: An analysis of technique specific observed/expected ratios for paralysis. (19394541)
2009
29
Pott's spinal caries: Pott's paraplegia. (19672082)
2009
30
Primary plasma cell leukemia presented as progressive paraplegia: a case report. (19077786)
2009
31
Novel compound heterozygous mutations of the SPG11 gene in Korean families with hereditary spastic paraplegia with thin corpus callosum. (19513778)
2009
32
Chinese patients with Machado-Joseph disease presenting with complicated hereditary spastic paraplegia. (19453404)
2009
33
Loss of spastic paraplegia gene atlastin induces age-dependent death of dopaminergic neurons in Drosophila. (17030474)
2008
34
Possible anticipation in hereditary spastic paraplegia type 4 (SPG4). (17598599)
2007
35
Hereditary spastic paraplegia with hypoplastic corpus callosum in a Turkish family. (17621486)
2007
36
Sudden paraplegia due to an anterior spinal artery syndrome during the course of Staphylococcus aureus septicemia. (17675832)
2007
37
Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein. (16602018)
2006
38
Primary lateral sclerosis, hereditary spastic paraplegia and amyotrophic lateral sclerosis: discrete entities or spectrum? (16036421)
2005
39
Spinal cord magnetic resonance imaging in autosomal dominant hereditary spastic paraplegia. (16143870)
2005
40
Meta-analysis of age at onset in spastin-associated hereditary spastic paraplegia provides no evidence for a correlation with mutational class. (12960222)
2003
41
Pathophysiology of paraplegia following endovascular thoracic aortic aneurysm repair. (12869184)
2003
42
Hereditary spastic paraplegia. (12512341)
2002
43
Is the transportation highway the right road for hereditary spastic paraplegia? (12355399)
2002
44
Paraplegia after epidural anesthesia in a patient with peripheral vascular disease: case report and review of the literature with a description of an original technique for hematoma evacuation. (10710156)
2000
45
Complicated hereditary spastic paraplegia with peripheral neuropathy, optic atrophy and mental retardation. (11071149)
2000
46
Evoked potentials in hereditary spastic paraplegia. (8282519)
1993
47
Possible role of collagen in transverse myelitis and chymopapain-induced paraplegia. (3964120)
1986
48
Paraplegia resulting from rupture of previously asymptomatic intramedullary hemangioblastoma during coitus. (4039910)
1985
49
Cervical fracture and paraplegia complicating diffuse idiopathic skeletal hyperostosis. (6712762)
1984
50
Paraplegia associated with cystinuria. (5541353)
1971

Genetic Variations for Paraplegia

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Expression for genes affiliated with Paraplegia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paraplegia

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Pathways for genes affiliated with Paraplegia

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Compounds for genes affiliated with Paraplegia

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GO Terms for genes affiliated with Paraplegia

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16Gene Ontology
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Cellular components related to Paraplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to membraneGO:01602110.8L1CAM, NIPA1, ATL1, AFG3L2, CYP2U1, PLP1
2midbodyGO:03049610.3ZFYVE26, SPG20, SPAST

Biological processes related to Paraplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:00821911.1SPG21, PLP1, ZFYVE26, CYP2U1, AFG3L2, ATL1
2protein catabolic processGO:03016310.5SPG7, AFG3L2
3axonogenesisGO:00740910.5ATL1, AFG3L2, SPAST
4anterograde axon cargo transportGO:00808910.3SPG7, KIF1A

Molecular functions related to Paraplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.6HSPD1, AP5Z1, ATL1, AFG3L2, ZFYVE26, KIF5A
2microtubule bindingGO:00801710.6SPAST, KIF1A, KIF5A
3unfolded protein bindingGO:05108210.5HSPD1, AFG3L2, SPG7

Products for genes affiliated with Paraplegia

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Sources for Paraplegia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet