MCID: PRS034
MIFTS: 38

Parasitic Helminthiasis Infectious Disease malady

Categories: Rare diseases, Infectious diseases, Gastrointestinal diseases

Aliases & Classifications for Parasitic Helminthiasis Infectious Disease

Aliases & Descriptions for Parasitic Helminthiasis Infectious Disease:

Name: Parasitic Helminthiasis Infectious Disease 12 14
Helminthiasis 12 50 52 42 69
Intestinal Helminthiasis 50 69
Helminth Infection 12
Worm Infections 50
Worm Infection 12
Helminthosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:883
ICD10 33 B65-B83 B83.9
MeSH 42 D006373
NCIt 47 C84751
UMLS 69 C0018889

Summaries for Parasitic Helminthiasis Infectious Disease

Disease Ontology : 12 A parasitic infectious disease that occurs when part of the body is infested with parasitic worms such as cestodes, nematodes and trematodes.

MalaCards based summary : Parasitic Helminthiasis Infectious Disease, also known as helminthiasis, is related to trichostrongyloidiasis and sparganosis. An important gene associated with Parasitic Helminthiasis Infectious Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. The drugs Iron and Ivermectin have been mentioned in the context of this disorder.

Related Diseases for Parasitic Helminthiasis Infectious Disease

Diseases related to Parasitic Helminthiasis Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
id Related Disease Score Top Affiliating Genes
1 trichostrongyloidiasis 31.8 CD40LG CD79A EPGN
2 sparganosis 31.8 CD79A IL4 MT-CO1 STH
3 coenurosis 31.7 CD79A CTSL IL4 IL5
4 keratomalacia 29.9 CD40LG CD79A IL10 IL4
5 screw worm infectious disease 11.1
6 philophthalmiasis 11.0
7 mesocestoidiasis 11.0
8 acanthocephaliasis 11.0
9 angiostrongyliasis 11.0
10 baylisascariasis 11.0
11 dioctophymiasis 11.0
12 taeniasis 11.0
13 hymenolepiasis 11.0
14 diphyllobothriasis 11.0
15 paragonimiasis 11.0
16 filariasis 11.0
17 strongyloidiasis 11.0
18 gnathomiasis 11.0
19 fascioloidiasis 11.0
20 echinostomiasis 11.0
21 dicrocoeliasis 11.0
22 capillariasis 11.0
23 trichuriasis 11.0
24 ancylostomiasis 11.0
25 clonorchiasis 11.0
26 opisthorchiasis 11.0
27 schistosomiasis 11.0
28 dracunculiasis 11.0
29 echinococcosis 11.0
30 necatoriasis 11.0
31 toxascariasis 11.0
32 ascaridiasis 11.0
33 oesophagostomiasis 11.0
34 ascariasis 11.0
35 anisakiasis 11.0
36 enterobiasis 11.0
37 heterophyiasis 11.0
38 metagonimiasis 11.0
39 fascioliasis 11.0
40 fasciolopsiasis 11.0
41 monieziasis 11.0
42 trichinosis 11.0
43 toxocariasis 11.0
44 dahlberg borer newcomer syndrome 10.4 IL13 IL5
45 exudative vitreoretinopathy 2, x-linked 10.3 IL13 IL5 MT-CO1
46 marasmus 10.3 IL4 IL5 RNASE3
47 thelaziasis 10.3 IL13 IL4 IL5
48 lens-induced iridocyclitis 10.3 IL4 IL5 RNASE3
49 lymphoblastic leukemia 10.3 IL13 IL4 IL5
50 alcoholic neuropathy 10.3 CD40LG CD79A

Graphical network of the top 20 diseases related to Parasitic Helminthiasis Infectious Disease:



Diseases related to Parasitic Helminthiasis Infectious Disease

Symptoms & Phenotypes for Parasitic Helminthiasis Infectious Disease

Drugs & Therapeutics for Parasitic Helminthiasis Infectious Disease

Drugs for Parasitic Helminthiasis Infectious Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 166)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 1 7439-89-6 23925
2
Ivermectin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 70288-86-7 6474909 46936176
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Praziquantel Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 55268-74-1 4891
5
Albendazole Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 54965-21-8 2082
6
Lumefantrine Approved Phase 4 82186-77-4 6437380
7
Artemether Approved Phase 4 71963-77-4 119380 68911
8
Zinc Approved Phase 4 7440-66-6 32051 23994
9
Copper Approved Phase 4 15158-11-9, 7440-50-8 27099
10
Azithromycin Approved Phase 4,Phase 2 83905-01-5 55185 53477736 447043
11
Piperazine Approved, Vet_approved Phase 4,Phase 3 110-85-0 4837
12
Mebendazole Approved, Vet_approved Phase 4,Phase 3 31431-39-7 4030
13
Diethylcarbamazine Approved, Vet_approved Phase 4,Phase 2,Phase 1 90-89-1 3052
14
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 5460373 44475014
15
Vitamin C Approved, Nutraceutical Phase 4,Phase 3 50-81-7 5785 54670067
16
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
17
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
18
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 11103-57-4, 68-26-8 445354
19
leucovorin Approved, Nutraceutical Phase 4 58-05-9 54575, 6560146 143
20
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
21
Nicotinamide Approved, Nutraceutical Phase 4 98-92-0 936
22
Thiamine Approved, Nutraceutical, Vet_approved Phase 4 59-43-8 1130
23
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
24
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
26
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
27
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
28 Benzimidazole Experimental Phase 4,Phase 1 51-17-2
29 Trace Elements Phase 4,Phase 2,Phase 3
30 Anthelmintics Phase 4,Phase 3,Phase 2,Phase 1
31 Vitamins Phase 4,Phase 3
32 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Protective Agents Phase 4,Phase 3
34 Antifungal Agents Phase 4
35 Antimalarials Phase 4,Phase 3,Phase 2
36 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Micronutrients Phase 4,Phase 2,Phase 3
38 Artemether-lumefantrine combination Phase 4
39 Artemisinine Phase 4
40 Artemisinins Phase 4
41 Antioxidants Phase 4,Phase 3
42 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1
44 vitamin d Phase 4
45
Iodine Phase 4 7553-56-2 807
46 cadexomer iodine Phase 4
47 Adjuvants, Immunologic Phase 4,Phase 1
48 Neuromuscular Agents Phase 4
49 Neuromuscular Blocking Agents Phase 4
50 Neuromuscular Depolarizing Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 207)
id Name Status NCT ID Phase
1 Artemisinin-based Combination Therapy-Intermittent Preventive Treatment (ACT-IPT) Trial Among Schoolchildren in Kassena-Nankana, Ghana Unknown status NCT01459146 Phase 4
2 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles Unknown status NCT00658294 Phase 4
3 Study to Evaluate Efficacy and Safety of a Double Treatment Plan Using a Combination of Mebendazole and Quinfamide for Treating Intestinal Helminthiasis and Amebiasis in the Mexican Population Completed NCT02385058 Phase 4
4 Efficacy of Albendazole to Treat Intestinal Helminths and Its Effect on Gut Microflora Completed NCT01192802 Phase 4
5 Efficacy Albendazole and Levamisole Against STH on Unguja Completed NCT00659997 Phase 4
6 Effect of Hookworm Elimination and Vitamin A Intervention on Iron Status of Preschool Children in Sichuan, China Completed NCT02675140 Phase 4
7 Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya Completed NCT01088958 Phase 4
8 The Effect of a Deworming Intervention to Improve Early Childhood Growth and Development in Resource-poor Areas Completed NCT01314937 Phase 4
9 Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis Completed NCT01593722 Phase 4
10 A Multinational Trial of the Efficacy of Albendazole Against Soil-transmitted Nematode Infections in Children Completed NCT01087099 Phase 4
11 Evaluation of Praziquantel Dosage for Treatment of Schistosomiasis in Brazil Completed NCT00403611 Phase 4
12 Effect of Schistosomiasis Mansoni on HIV Susceptibility and Female Genital Immunology Completed NCT02878564 Phase 4
13 The Efficacy of Five Anthelmintic Regimes Against Trichuris Trichiura Infections in Schoolchildren in Jimma, Ethiopia Completed NCT01327469 Phase 4
14 Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali Completed NCT02784743 Phase 4
15 Impact of Alternative Treatment Strategies and Delivery Systems for Soil-transmitted Helminths in Kenya Recruiting NCT02397772 Phase 4
16 Twice Yearly Treatment for the Control of LF Recruiting NCT03036059 Phase 4
17 Clinical Trial of Efficacy and Safety of Ergoferon in the Treatment of Viral Intestinal Infections in Children Recruiting NCT03039699 Phase 4
18 Postpartum Deworming: Improving Breastfeeding and Optimizing Infant Growth Active, not recruiting NCT01748929 Phase 4
19 Intestinal Microbiome Post-Azythromycin/Albendazole Treatment Not yet recruiting NCT03032042 Phase 4
20 Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH) Not yet recruiting NCT03014167 Phase 4
21 Repeated Doses of Praziquantel in Schistosomiasis Treatment (RePST) Not yet recruiting NCT02868385 Phase 4
22 Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis Not yet recruiting NCT02734186 Phase 4
23 Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy Not yet recruiting NCT03052998 Phase 4
24 The Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in Vietnamese School Children Withdrawn NCT02597556 Phase 4
25 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4
26 Ivermectin Versus Albendazole for Chronic Strongyloidiasis Unknown status NCT00765024 Phase 3
27 A Study to Assess the Efficacy and Safety of Mebendazole for the Treatment of Helminth Infections in Pediatric Participants Completed NCT02034162 Phase 3
28 Comparative Efficacy of Different Mebendazole Polymorphs in the Treatment of Soil-transmitted Helminth Infections Completed NCT01350271 Phase 3
29 Design and Clinical Evaluation of a School Meal With Deworming Properties Completed NCT02725255 Phase 2, Phase 3
30 Deworming and Vitamin A (DEVTA) Prepilot Study Completed NCT00396500 Phase 3
31 Effects of 2 Different Duration of Albendazole Therapy in Patients With Neurocysticercosis in Brain ≤ 5 Lesions on CT Completed NCT02243644 Phase 3
32 A Pilot Study of Neurocysticercosis Treatment Completed NCT00283699 Phase 3
33 Neurocysticercosis: Combined Treatment With Praziquantel (PZQ) and Albendazole (ABZ) Completed NCT00441285 Phase 2, Phase 3
34 Corticosteroids to Reduce Frequency of Seizures in Neurocysticercosis Patients Completed NCT00290823 Phase 3
35 Schistosoma Haematobium Infections and Praziquantel Completed NCT01558336 Phase 3
36 Safety and Efficacy of Mirazid for Schistosomiasis Treatment Completed NCT01529710 Phase 3
37 Efficacy of Bilhvax in Association With Praziquantel for Prevention of Clinical Recurrences of Schistosoma Haematobium Completed NCT00870649 Phase 3
38 Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection Completed NCT00790998 Phase 3
39 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
40 Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study Completed NCT02509481 Phase 2, Phase 3
41 Treatment of Peri-calcification Edema in Neurocysticercosis (NCC) Recruiting NCT02945527 Phase 2, Phase 3
42 The Chinese-made Praziquantel for Treatment of Schistosoma Haematobium Recruiting NCT03133832 Phase 3
43 Multiple Versus Single Dose of Ivermectin for the Treatment of Strongyloidiasis Active, not recruiting NCT01570504 Phase 3
44 Treatment of Asymptomatic Toxocariasis With Albendazole in Children Active, not recruiting NCT00755560 Phase 3
45 Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana Not yet recruiting NCT02078024 Phase 3
46 Sub Arachnoid Neurocysticercosis Treatment Outcome (SANTO) Not yet recruiting NCT02947581 Phase 3
47 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Not yet recruiting NCT02929134 Phase 3
48 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3
49 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Not yet recruiting NCT02927496 Phase 3
50 RCT ALB for SA Cysticercosis Withdrawn NCT00133458 Phase 3

Search NIH Clinical Center for Parasitic Helminthiasis Infectious Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: helminthiasis

Genetic Tests for Parasitic Helminthiasis Infectious Disease

Anatomical Context for Parasitic Helminthiasis Infectious Disease

Publications for Parasitic Helminthiasis Infectious Disease

Variations for Parasitic Helminthiasis Infectious Disease

Expression for Parasitic Helminthiasis Infectious Disease

Search GEO for disease gene expression data for Parasitic Helminthiasis Infectious Disease.

Pathways for Parasitic Helminthiasis Infectious Disease

Pathways related to Parasitic Helminthiasis Infectious Disease according to GeneCards Suite gene sharing:

(show all 20)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.18 CD40LG IL10 IL13 IL4 IL5 SNAI1
2
Show member pathways
12.54 CD40LG CTSL IL10 IL13 IL4 IL5
3
Show member pathways
12.3 CD40LG IL10 IL4 IL5
4
Show member pathways
12.09 IL10 IL13 IL4 IL5
5
Show member pathways
12.03 IL10 IL13 IL4 IL5
6 11.86 CD79A IL10 IL4 IL5
7 11.67 IL13 IL4 IL5
8 11.66 IL10 IL13 IL4 IL5
9
Show member pathways
11.63 CD40LG IL4 IL5
10 11.55 CD40LG IL10 IL4 IL5
11 11.53 IL13 IL4 IL5
12 11.42 CD40LG IL10 IL4 IL5
13 11.4 IL10 IL13 IL4
14 11.2 CD40LG IL4 IL5
15 11.16 IL13 IL4 IL5
16 11.13 IL10 IL13 IL4 IL5
17 11.06 CD40LG IL10 IL13 IL4 IL5
18 10.73 IL10 IL13 IL4 IL5
19 10.72 IL13 IL4 IL5
20 10.34 IL10 IL13 IL4 IL5

GO Terms for Parasitic Helminthiasis Infectious Disease

Cellular components related to Parasitic Helminthiasis Infectious Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.26 CD40LG CD79A IL13 IL4
2 extracellular space GO:0005615 9.23 CD40LG CTSL EPGN IL10 IL13 IL4

Biological processes related to Parasitic Helminthiasis Infectious Disease according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.91 CD40LG IL10 IL13 IL4 IL5
2 microglial cell activation GO:0001774 9.55 IL13 IL4
3 negative regulation of nitric oxide biosynthetic process GO:0045019 9.54 IL10 IL4
4 positive regulation of macrophage activation GO:0043032 9.52 IL10 IL13
5 positive regulation of B cell proliferation GO:0030890 9.5 IL13 IL4 IL5
6 positive regulation of mast cell degranulation GO:0043306 9.49 IL13 IL4
7 positive regulation of MHC class II biosynthetic process GO:0045348 9.48 IL10 IL4
8 positive regulation of immunoglobulin production GO:0002639 9.46 IL13 IL4
9 type 2 immune response GO:0042092 9.43 IL10 IL4
10 B cell proliferation GO:0042100 9.43 CD40LG CD79A IL10
11 regulation of isotype switching GO:0045191 9.4 IL10 IL4
12 regulation of proton transport GO:0010155 9.37 IL13 IL4
13 negative regulation of complement-dependent cytotoxicity GO:1903660 9.16 IL13 IL4
14 negative regulation of endothelial cell apoptotic process GO:2000352 9.13 IL10 IL13 IL4
15 B cell differentiation GO:0030183 8.92 CD40LG CD79A IL10 IL4

Molecular functions related to Parasitic Helminthiasis Infectious Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 EPGN IL10 IL4 IL5
2 cytokine activity GO:0005125 9.02 CD40LG IL10 IL13 IL4 IL5

Sources for Parasitic Helminthiasis Infectious Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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