MCID: PRT029
MIFTS: 52

Parathyroid Adenoma malady

Cancer diseases, Endocrine diseases categories
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Summaries for Parathyroid Adenoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 A parathyroid adenoma is a benign tumor of the parathyroid gland. It generally causes... more...

MalaCards: Parathyroid Adenoma, also known as adenoma of the parathyroid gland, is related to adenoma and hyperparathyroidism. An important gene associated with Parathyroid Adenoma is MEN1 (multiple endocrine neoplasia I), and among its related pathways are Endochondral Ossification and Development Hedgehog and PTH signaling pathways in bone and cartilage development. The compounds calcium carbonate and alendronate have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and breast, and related mouse phenotypes are digestive/alimentary and integument.

Aliases & Classifications for Parathyroid Adenoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 35MeSH, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

parathyroid adenoma 8 10 45 62
adenoma of the parathyroid gland 8


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Disease Ontology8 DOID:7608
NCIt40 C3916
SNOMED-CT58 128474007
MeSH35 D010282

Related Diseases for Parathyroid Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Parathyroid Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.8CHGA, CDKN2C, CDC73, CASR, MEN1, CHGB
2hyperparathyroidism31.3MEN1, CDC73, PTH, PTHLH, CHGA, CASR
3primary hyperparathyroidism31.2CDC73, CASR, MEN1, CHGA, PTHLH, PTH
4parathyroid carcinoma31.0CASR, MEN1, CDC73, PTH
5osteitis fibrosa30.9PTH, CASR
6hypercalcemia30.7CDC73, PTH, PTHLH, CHGA, MEN1, CASR
7multiple endocrine neoplasia type 2a30.5CDC73, MEN1, PTH
8multiple endocrine neoplasia30.3MEN1, CDC73, CHGA, CHGB
9thyroid cancer30.3PTH, CHGA
10pheochromocytoma30.3CHGB, CHGA, MEN1
11rickets30.2PTH, CASR
12breast cancer30.2CHGA, CHGB, PTHLH
13vipoma30.1CHGA, MEN1
14osteomalacia30.1PTHLH, CASR, PTH
15paraganglioma30.0CHGB, CHGA, MEN1
16mediastinitis11.0
17thyroiditis10.9
18cervicitis10.6
19papillary thyroid carcinoma10.6
20papillary carcinoma10.5
21goiter10.5
22multinodular goiter10.4
23sarcoidosis10.4
24follicular adenoma10.3
25pancreatitis10.3
26thymoma10.3
27aortopulmonary window10.3
28mixed cell type adenoma of parathyroid10.3
29water-clear cell adenoma10.3
30clear cell adenoma10.3
31neurofibromatosis10.2
32acute pancreatitis10.2
33cerebritis10.2
34hepatocellular carcinoma10.2
35laryngitis10.2
36meningioma10.2
37multiple myeloma10.2
38myeloma10.2
39renal cell carcinoma10.2
40medullary sponge kidney10.2
41parathyroid adenoma with cystic changes10.2
42parathyroid adenoma, somatic10.2
43hyperparathyroidism-jaw tumor syndrome10.1CDC73
44brachydactyly10.1PTH
45familial isolated hyperparathyroidism10.1CDC73, MEN1
46pseudohypoparathyroidism type 1b10.1PTH, PTHLH
47bone fracture10.1
48ossifying fibroma10.1
49polycythemia vera10.1
50geotrichosis10.1

Graphical network of the top 20 diseases related to Parathyroid Adenoma:



Diseases related to parathyroid adenoma

Symptoms for Parathyroid Adenoma

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Drugs & Therapeutics for Parathyroid Adenoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Search NIH Clinical Center for Parathyroid Adenoma

Genetic Tests for Parathyroid Adenoma

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Anatomical Context for Parathyroid Adenoma

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33MalaCards
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MalaCards organs/tissues related to Parathyroid Adenoma:

33
Thyroid, Bone, Breast, Lymph node, Lung, Kidney, Thymus, Liver, Salivary gland, Testes, Pituitary

Animal Models for Parathyroid Adenoma or affiliated genes

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37MGI
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Publications for Parathyroid Adenoma

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52PubMed
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Articles related to Parathyroid Adenoma:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Successful Detection and Removal of a Functional Parathyroid Adenoma in a Pony Using Technetium Tc 99m Sestamibi Scintigraphy. (24417704)
2014
2
Intrathymic parathyroid adenoma presenting with seizures. (23550471)
2013
3
The role of single-photon emission computed tomography/computed tomography in localizing parathyroid adenoma. (23660759)
2013
4
Delayed surgery for parathyroid adenoma misdiagnosed as a thyroid nodule and treated with radiofrequency ablation. (24396684)
2013
5
Octreotide uptake in parathyroid adenoma. (23487397)
2012
6
SPECT-CT in the localization of an ectopic retropharyngeal parathyroid adenoma as a cause for persistent primary hyperparathyroidism. (23067531)
2012
7
Giant parathyroid adenoma. (22610816)
2011
8
Interesting image. Unusual parathyroid adenoma avid for both Tc-99m sestamibi and I-123 iodine. (20940552)
2010
9
The use of gamma probe for the intraoperative localization of an ectopic parathyroid adenoma. (19714514)
2009
10
Normal parathyroid hormone levels in a diabetic patient with parathyroid adenoma. (19116787)
2009
11
Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism. (19491068)
2009
12
Cervical approach by lifting the superior sternum for mediastinal parathyroid adenoma. (19238073)
2009
13
Tc-99m sestamibi uptake mimicking parathyroid adenoma in a patient with primary hyperparathyroidism and occult multiple myeloma. (18287846)
2008
14
Ectopic parathyroid adenoma in child. (19548602)
2008
15
Dual-phase 99mTc-MIBI parathyroid imaging reveals synchronous parathyroid adenoma and papillary thyroid carcinoma: a case report. (19181586)
2008
16
Intraoperative parathyroid hormone assay improves outcomes of minimally invasive parathyroidectomy mainly in patients with a presumed solitary parathyroid adenoma and missing concordance of preoperative imaging. (17437518)
2007
17
Primary hyperparathyroidism due to parathyroid adenoma. (17268723)
2007
18
Water-clear cell parathyroid adenoma causing primary hyperparathyroidism in a patient with neurofibromatosis type 1: report of a case. (17879040)
2007
19
High resolution MRI in the detection of an intrathymic parathyroid adenoma. (16940365)
2006
20
Intrathyroidal parathyroid adenoma. (15965320)
2005
21
Parathyroid adenoma presenting as paraneoplastic syndrome secondary to renal cell carcinoma. (16048706)
2005
22
A case of Costello with parathyroid adenoma and hyperprolactinemia. (14699620)
2004
23
Preoperative diagnosis of suspicious parathyroid adenomas by RT-PCR using mRNA extracted from leftover cells in a needle used for ultrasonically guided fine needle aspiration cytology. (12585024)
2003
24
Distinct target regions for chromosome 1p deletions in parathyroid adenomas and carcinomas. (12239610)
2002
25
Using technetium 99m tetrofosmin parathyroid imaging to detect parathyroid adenoma and its relation to P-glycoprotein expression. (12324759)
2002
26
Large carotid sheath parathyroid adenoma localized by Tc-99m sestamibi. (11139048)
2001
27
Thoracoscopically managed parathyroid adenoma in the upper anterior mediastinum. (11822866)
2001
28
Frequent loss of heterozygosity at 1p36.3 and p73 abnormality in parathyroid adenomas. (11301342)
2001
29
Visual vignette. Hyperparathyroidism due to a parathyroid adenoma. (11441818)
2000
30
Multiple brown tumors simulating bone metastases: a case of parathyroid adenoma coexisting with papillary carcinoma of the thyroid. (11043714)
2000
31
Median sternotomy for parathyroid adenoma. (10098336)
1999
32
Loss of wild-type MEN1 gene expression in multiple endocrine neoplasia type 1-associated parathyroid adenoma. (10580746)
1999
33
False-positive Tc-99m sestamibi examination for parathyroid adenoma in a case of asymmetrical salivary gland enlargement. (10478765)
1999
34
Bilateral hemothorax revealing mediastinal parathyroid adenoma. (10202326)
1999
35
The ectopic parathyroid adenoma: a cost justification for routine preoperative localization with technetium Tc 99m sestamibi scan. (9639474)
1998
36
Aspiration cytology of parathyroid adenoma: radioimmunoassay of parathormone in aspirate as a helpful diagnostic tool. (9622722)
1998
37
Papillary thyroid carcinoma, parathyroid adenoma, and unexplained hypercalcitoninemia: an unusual presentation of multiple endocrine neoplasia type 2A? (9777749)
1998
38
Dyshormonogenetic goitre with clear cell change resembling parathyroid adenoma--a case report. (9866911)
1998
39
Intraoperative use of methylene blue to localize parathyroid adenoma. (9591562)
1998
40
Parathyroid adenoma, hyperplasia, and carcinoma: localization, technical details of primary neck exploration, and treatment of hypercalcemic crisis. (9735131)
1998
41
You're the flight surgeon. Parathyroid adenoma with primary hyperparathyroidism, recurrent renal calculi, and brown tumor. (9773908)
1998
42
Location of a small mediastinal parathyroid adenoma using Tc-99m MIBI SPECT. (9509943)
1998
43
Kinetics of Tc-99m sestamibi and Tc-99m tetrofosmin in a case of parathyroid adenoma. (8879870)
1996
44
Differences in PTH (1-84) release in response to ambient calcium concentrations of parathyroid adenoma fragments and dispersed parathyroid adenoma cells in culture. (8844452)
1996
45
Persistent elevated serum levels of intact parathyroid hormone after operation for sporadic parathyroid adenoma: evidence of detrimental effects of severe parathyroid disease. (8650602)
1996
46
Absence of cyclin D1/PRAD1 point mutations in human breast cancers and parathyroid adenomas and identification of a new cyclin D1 gene polymorphism. (7621424)
1995
47
Preoperative localization of a parathyroid adenoma with Tc-99m sestamibi imaging in a patient with concomitant nontoxic multinodular goiter. (7895432)
1995
48
Clonal analysis of parathyroid adenomas by means of the polymerase chain reaction. (7910112)
1994
49
Tc-99m sestamibi imaging of a pancreatic VIPoma and parathyroid adenoma in a patient with multiple type I endocrine neoplasia. (7914844)
1994
50
Immunohistochemical localization of parathyroid hormone-related protein in parathyroid adenoma and hyperplasia. (2196348)
1990

Variations for Parathyroid Adenoma

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Expression for genes affiliated with Parathyroid Adenoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Parathyroid Adenoma

Search GEO for disease gene expression data for Parathyroid Adenoma.

Pathways for genes affiliated with Parathyroid Adenoma

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters
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Pathways related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6PTHLH, PTH
29.6PTHLH, PTH

Compounds for genes affiliated with Parathyroid Adenoma

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45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Parathyroid Adenoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1calcium carbonate4510.0PTHLH, PTH
2alendronate45 51 1111.9PTHLH, PTH
3leupeptin459.9PTH, PTHLH
422-oxacalcitriol459.9CASR, PTHLH
5hydroxyproline45 24 1111.9PTHLH, PTH
6bicarbonate459.7PTHLH, PTH
7hydroxyapatite459.7CASR, PTHLH
8ag 1478459.7PTHLH, PTH
9neomycin459.7PTHLH, CASR
10aprotinin45 1110.6PTH, PTHLH
11pamidronate45 51 1111.5PTH, PTHLH, CASR
1225-hydroxyvitamin d459.5PTH, PTHLH, CASR
13thymidine45 2410.5PTH, PTHLH, MEN1
14phosphorus459.5PTH, PTHLH, CASR
151,25 dihydroxy vitamin d3459.5PTH, PTHLH, CASR
16l-amino acid459.5CHGA, CASR
17calcitriol45 61 24 1112.5CASR, PTHLH, PTH
18secretoneurin459.4CHGA, CHGB
19octreotide45 61 29 1112.4CHGA, PTHLH
20peptidylglycine459.4CHGB, CHGA
21acth459.4CHGB, CHGA
22pge2459.4PTH, PTHLH, CASR
23sodium45 2410.3CASR, PTHLH, PTH
24bromodeoxyuridine459.2PTH, PTHLH, CHGA
25isoproterenol45 1110.2CHGA, PTHLH, PTH
26tamoxifen45 51 29 1112.1CHGA, PTHLH, PTH
27catecholamine459.0CHGA, CHGB
28magnesium45 24 1111.0CASR, PTHLH, PTH
29hydrogen45 2410.0CASR, CHGA, PTHLH
30cycloheximide458.9CHGA, PTHLH, PTH
31norepinephrine45 24 1110.9PTHLH, CHGB, CHGA
32potassium45 24 1110.9CASR, CHGB, PTHLH, PTH
33vegf458.8PTH, PTHLH, CHGA, MEN1
34ribonucleic acid458.7PTH, PTHLH, CHGA, CASR
35forskolin45 51 1110.7PTH, PTHLH, CHGA, CASR
36creatinine458.7CASR, CHGA, PTHLH, PTH
37adenylate458.7PTH, PTHLH, CHGA, CASR
38cyclic amp45 249.7CASR, CHGA, PTHLH, PTH
39arginine458.6PTH, PTHLH, CHGA, CASR
40nitric oxide45 24 1110.6PTH, PTHLH, CHGA, CASR
41glucose458.6CASR, CHGA, PTHLH, PTH
42dexamethasone45 51 29 1111.5CHGA, CHGB, PTHLH, PTH
43inositol 1,4,5 trisphosphate458.5CASR, CHGA, CHGB, PTH
44testosterone45 61 24 1111.5CHGA, PTHLH, PTH
45vitamin d458.4CASR, MEN1, CHGA, PTHLH, PTH
46estrogen457.7PTH, PTHLH, CHGB, CHGA, MEN1, CASR
47tyrosine457.7PTH, PTHLH, CHGB, CHGA, MEN1, CASR
48calcium45 51 24 1110.7PTH, PTHLH, CHGB, CHGA, MEN1, CASR
49serine457.6PTHLH, CHGB, CHGA, MEN1, CASR, CDKN2C

GO Terms for genes affiliated with Parathyroid Adenoma

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16Gene Ontology
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Cellular components related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301418.7CHGA, CHGB
2extracellular regionGO:0055768.2CHGA, CHGB, PTHLH, PTH

Biological processes related to Parathyroid Adenoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1osteoblast developmentGO:0020769.8MEN1, PTHLH
2cAMP metabolic processGO:0460589.8PTHLH, PTH
3positive regulation of cAMP biosynthetic processGO:0308199.7PTHLH, PTH
4adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.7PTH, PTHLH
5regulation of gene expressionGO:0104689.6PTHLH, PTH
6negative regulation of sequence-specific DNA binding transcription factor activityGO:0434339.6MEN1, PTHLH
7negative regulation of transcription from RNA polymerase II promoterGO:0001229.3CDC73, MEN1, PTH
8cellular calcium ion homeostasisGO:0068749.2PTH, CASR
9negative regulation of cell proliferationGO:0082859.0PTHLH, MEN1, CDC73, CDKN2C

Molecular functions related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:0514289.6PTHLH, PTH
2hormone activityGO:0051798.7CHGB, PTHLH, PTH

Products for genes affiliated with Parathyroid Adenoma

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Sources for Parathyroid Adenoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet