MCID: PRT029
MIFTS: 56

Parathyroid Adenoma malady

Endocrine diseases category

Summaries for Parathyroid Adenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A parathyroid adenoma is a benign tumor of the parathyroid gland. It generally causes... more...

MalaCards: Parathyroid Adenoma, also known as adenoma of the parathyroid gland, is related to adenoma and hyperparathyroidism. An important gene associated with Parathyroid Adenoma is CDC73 (cell division cycle 73), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Cell cycle. The compounds estrogen and forskolin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and breast, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Aliases & Classifications for Parathyroid Adenoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

parathyroid adenoma 8 10 44 60
adenoma of the parathyroid gland 8


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Disease Ontology8 DOID:7608
NCIt39 C3916
SNOMED-CT56 128474007
MeSH34 D010282

Related Diseases for Parathyroid Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Parathyroid Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma32.0LGALS3, PTH, CXADR, RET, CDKN2C, CDKN1B
2hyperparathyroidism31.4ALPP, PTH, PTHLH, CXADR, RET, CDKN1B
3primary hyperparathyroidism31.4ALPP, PTH, PTHLH, CXADR, RET, CDC73
4parathyroid carcinoma31.2PTH, CXADR, CDC73, MEN1, CASR
5thyroiditis31.2CALCA
6papillary carcinoma30.9LGALS3, RET, CDKN1B, CHGA, GNAS, CALCA
7papillary thyroid carcinoma30.9LGALS3, RET, MEN1, CALCA, CCND1
8hypercalcemia30.9ALPP, PTH, PTHLH, CXADR, CDC73, VDR
9osteitis fibrosa30.7ALPP, PTH, GNAS, CASR
10goiter30.6LGALS3, PTH, RET, GNAS, CALCA
11follicular adenoma30.5LGALS3, RET, GNAS, CALCA
12sarcoidosis30.4ALPP
13pancreatitis30.3ALPP, CASR
14meningioma30.2CXADR, FGFR2, CDKN2C, MEN1
15neurofibromatosis30.2RET
16multiple endocrine neoplasia type 2a30.2PTH, RET, CDC73, MEN1, CALCA
17follicular thyroid carcinoma30.2LGALS3, RET, CALCA
18myeloma30.2ALPP, PTHLH, ABCB1, CDKN2C, CCND1
19pheochromocytoma30.2RET, CHGB, CHGA, MEN1, GNAS, CALCA
20thyroid cancer30.2LGALS3, RET, CDKN1B, GNAS, CASR, CALCA
21thyroid medullary carcinoma30.2LGALS3, RET, CHGB, CHGA, PRKAR1A, MEN1
22breast cancer30.2LGALS3, PTHLH, ABCB1, FGFR2, CDKN1B, CHGB
23hepatocellular carcinoma30.2ALPP, ABCB1, CXADR, FGFR2, CDKN2C, CDKN1B
24multiple myeloma30.2ABCB1, CCND1
25obesity30.0GNAS
26hypertension30.0PTH, CALCA
27vipoma30.0CHGA, MEN1
28hyperthyroidism30.0ALPP, PTH, GNAS
29hypogonadism30.0CALCA
30cholangiocarcinoma30.0ALPP, LGALS3, CDKN1B
31rickets30.0ALPP, PTH, VDR, CASR
32familial medullary thyroid carcinoma30.0RET, CALCA
33hyperprolactinemia30.0PTHLH, GNAS
34hemangioma30.0RET, MEN1
35papilloma30.0CDKN1B
36squamous cell carcinoma30.0LGALS3, PTHLH, CCND1
37nodular goiter30.0LGALS3, RET, CALCA
38paraganglioma30.0RET, CHGB, CHGA, MEN1, CALCA
39ossifying fibroma30.0CDC73
40astrocytoma30.0LGALS3, CXADR, FGFR2, CDKN1B, CASR
41diabetes mellitus30.0ALPP, PTH, VDR, CASR, CALCA
42chondrosarcoma30.0PTHLH, FGFR2
43osteomalacia30.0ALPP, PTH, PTHLH, VDR, GNAS, CASR
44lung cancer30.0PTHLH, ABCB1, CXADR, CHGA
45pituitary adenoma30.0LGALS3, FGFR2, RET, CDKN1B, CHGB, CHGA
46mediastinitis10.9
47papillary adenoma10.6
48cervicitis10.6
49oxyphilic adenoma10.4
50multinodular goiter10.4

Graphical network of the top 20 diseases related to Parathyroid Adenoma:



Diseases related to parathyroid adenoma

Clinical Features for Parathyroid Adenoma

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Drugs & Therapeutics for Parathyroid Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Parathyroid Adenoma

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Anatomical Context for Parathyroid Adenoma

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32MalaCards
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MalaCards organs/tissues related to Parathyroid Adenoma:

32
Thyroid, Bone, Breast, Pituitary, Lymph node, Kidney, Thymus, Lung, Liver, Salivary gland, Testes

Animal Models for Parathyroid Adenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Parathyroid Adenoma:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537710.3CDKN1B, GNAS
2MP:000536710.2CASR, GNAS, CHGA, CDC73, RET, FGFR2
3MP:000537510.2GNAS, PRKAR1A, CDC73
4MP:000536910.1CASR, MEN1, PRKAR1A, VDR, CDC73, RET
5MP:000539010.1CCND1, GNAS, PRKAR1A, FGFR2, PTHLH, LGALS3
6MP:000537910.1CXADR, FGFR2, RET, CDKN2C, CDKN1B, CDC73
7MP:000363110.1GNAS, CHGB, VDR, CDC73, RET, FGFR2
8MP:000538810.1CCND1, GNAS, PRKAR1A, CDKN1B, CDKN2C, FGFR2
9MP:000538910.0CCND1, MEN1, PRKAR1A, VDR, CDC73, CDKN1B
10MP:001077110.0CCND1, CALCA, CASR, GNAS, VDR, CDC73
11MP:000537010.0ABCB1, FGFR2, CDKN1B, CDC73, MEN1, GNAS
12MP:000538210.0CCND1, GNAS, MEN1, PRKAR1A, VDR, CDKN1B
13MP:00020069.9CCND1, CALCA, MEN1, PRKAR1A, CDKN1B, CDKN2C
14MP:00053769.9PRKAR1A, MEN1, GNAS, CASR, CALCA, CHGB
15MP:00053819.9VDR, PRKAR1A, MEN1, CASR, CCND1, CDC73
16MP:00053869.7VDR, GNAS, CASR, CALCA, CCND1, CDC73
17MP:00053809.7PRKAR1A, CDC73, RET, FGFR2, CXADR, ALPP
18MP:00053979.7CDC73, VDR, PRKAR1A, GNAS, CASR, CCND1
19MP:00053789.6CHGA, PRKAR1A, MEN1, GNAS, CASR, CCND1
20MP:00053879.6CDC73, VDR, PRKAR1A, MEN1, GNAS, CASR
21MP:00053849.6VDR, PRKAR1A, MEN1, GNAS, CASR, CCND1
22MP:00053859.6LGALS3, CALCA, CCND1, GNAS, MEN1, PTH
23MP:00107689.4VDR, CHGA, PRKAR1A, MEN1, GNAS, CASR

Publications for Parathyroid Adenoma

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50PubMed
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Articles related to Parathyroid Adenoma:

(show top 50)    (show all 614)
idTitleAuthorsYear
1
Delayed surgery for parathyroid adenoma misdiagnosed as a thyroid nodule and treated with radiofrequency ablation. (24396684)
2013
2
Parathyroid carcinoma and oxyphil parathyroid adenoma: an uncommon case of misinterpretation in clinical practice. (23268928)
2013
3
A Case of a Retroesophageal Parathyroid Adenoma with an Aberrant Right Subclavian Artery: A Potential Surgical Pitfall. (23411847)
2013
4
A Case of an Acute Cervicomediastinal Hematoma Secondary to the Spontaneous Rupture of a Parathyroid Adenoma. (23445790)
2013
5
Incidental finding of parathyroid adenoma with 11C-choline PET/CT. (22614195)
2012
6
Primary hyperparathyroidism: fifth parathyroid intrathymic adenoma in a young patient. (23155710)
2012
7
Giant parathyroid adenoma. (22610816)
2011
8
Acute airway compromise from a hemorrhagic posterior cervical-mediastinal mass: Rare presentation of a parathyroid adenoma. (22263063)
2011
9
Interesting image. Unusual parathyroid adenoma avid for both Tc-99m sestamibi and I-123 iodine. (20940552)
2010
10
Granulomatous infiltration of a parathyroid adenoma presenting as primary hyperparathyroidism in a woman: a case report. (21143903)
2010
11
Cystic parathyroid adenoma: sonographic features and correlation with 99mTc-sestamibi SPECT findings. (21098199)
2010
12
Surgical treatment of mediastinal parathyroid adenoma: rationale for intraoperative parathyroid hormone monitoring. (20494022)
2010
13
Ipsilateral double parathyroid adenoma and thyroid hemiagenesis. (20733341)
2010
14
Normal parathyroid hormone levels in a diabetic patient with parathyroid adenoma. (19116787)
2009
15
Beneficial effect of endocrinologist-performed ultrasonography on preoperative parathyroid adenoma localization. (19211392)
2009
16
Radio-guided surgical excision of an ectopic mediastinal parathyroid adenoma demonstrated on Tc-99m sestamibi hybrid imaging. (19220551)
2009
17
Giant mediastinal parathyroid adenoma: a case report. (19537125)
2009
18
Parathyroid adenoma as a cause of vocal fold paralysis. (19620594)
2009
19
Substernal oxyphil parathyroid adenoma producing PTHrP with hypercalcemia and normal PTH level. (18291038)
2008
20
Absence of stabilizing mutations of beta-catenin encoded by CTNNB1 exon 3 in a large series of sporadic parathyroid adenomas. (17284619)
2007
21
Distribution of solitary parathyroid adenoma over the parathyroid glands and its surgical management. (17999854)
2007
22
Video-assisted mediastinoscopy (VAM) for surgical resection of ectopic parathyroid adenoma. (17937802)
2007
23
Cholangiocarcinoma, renal cell carcinoma and parathyroid adenoma found synchronously in a patient on long-term methotrexate. (18333265)
2006
24
Minimally invasive management of the mediastinal parathyroid adenoma. (16540913)
2006
25
Correlations between parathyroid adenoma weight and biochemical values. (17103097)
2006
26
Parathyroid adenoma presenting as paraneoplastic syndrome secondary to renal cell carcinoma. (16048706)
2005
27
Excision of a mediastinal parathyroid adenoma after coronary artery bypass surgery. (16122500)
2005
28
Mediastinal parathyroid adenoma. (15734465)
2005
29
Parathyroid adenoma with ectopic intrathymic parathyroid--a case report. (16758787)
2005
30
Expression of GCMB by intrathymic parathyroid hormone-secreting adenomas indicates their parathyroid cell origin. (14715818)
2004
31
Preoperative diagnosis of suspicious parathyroid adenomas by RT-PCR using mRNA extracted from leftover cells in a needle used for ultrasonically guided fine needle aspiration cytology. (12585024)
2003
32
Secondary hyperparathyroidism after removal of a parathyroid adenoma. (15260008)
2002
33
Mutational analysis of Smad3, a candidate tumor suppressor implicated in TGF-beta and menin pathways, in parathyroid adenomas and enteropancreatic endocrine tumors. (12161532)
2002
34
Underexpression of Gcm2, a master regulatory gene of parathyroid gland development, in adenomas of primary hyperparathyroidism. (12354132)
2002
35
An unusual cause of hypercalcemia in polycythemia vera: parathyroid adenoma. (12108588)
2002
36
Large carotid sheath parathyroid adenoma localized by Tc-99m sestamibi. (11139048)
2001
37
Identification and management of intravagal parathyroid adenoma. (11344391)
2001
38
99mTc-Sestamibi scan in a patient with an ectopic parathyroid adenoma. (11310395)
2000
39
No evidence for mutations in the calcium-sensing receptor gene in sporadic parathyroid adenomas. (10352095)
1999
40
A peculiar Factor VIII-related antigen staining of an oxyphilic cell nodule within an intrathyroidal parathyroid adenoma. (10338086)
1999
41
Partial ablation of mediastinal parathyroid adenoma by angiography: documentation with Tc-99m sestamibi scintigraphy. (9509938)
1998
42
Radiological case of the month. Ectopic parathyroid adenoma of the upper mediastinum. (9114650)
1997
43
Water-clear cell adenoma of the parathyroid. A case report with immunohistochemistry and electron microscopy. (7487410)
1995
44
Tc-99m sestamibi uptake by parathyroid carcinoma. False-positive localization of parathyroid adenoma. (7586884)
1995
45
Documentation of parathyroid carcinoma fifteen years after resection of a parathyroid 'adenoma'. (8334754)
1993
46
Fungal superinfection: geotrichosis of the urinary tract in association with parathyroid adenoma. (4872500)
1968
47
Comparison between the results of radiocalcium studies and histological findings in a case of primary hyperparathyroidism (osteitis fibrosa cystica generalisata of von Recklinghausen) before and after removal of parathyroid adenoma. (5921154)
1966
48
Parathyroid adenoma in a child; report of a case presenting as central nervous system disease and complicated by magnesium deficiency. (13301145)
1956
49
Parathyroid adenoma with generalized osteitis fibrosa cystica. (13027296)
1953
50
Hyperparathyroidism--osteitis fibrosa cystica parathyroid adenoma--with report of a case. (14880989)
1951

Genetic Variations for Parathyroid Adenoma

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Expression for genes affiliated with Parathyroid Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Parathyroid Adenoma

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Pathways for genes affiliated with Parathyroid Adenoma

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12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 4Cell Signaling Technology
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Pathways related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.3PTH, VDR
2
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10.3MEN1, CDKN1B, CDKN2C
3
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10.3CDKN2C, CDKN1B, CCND1
4
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10.2CDKN2C, CDKN1B, CDC73, CCND1
5
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10.2CCND1, CDKN1B, CDKN2C, FGFR2
6
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10.2CDKN1B, VDR, PRKAR1A, GNAS
7
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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10.0PTH, CCND1, GNAS, PRKAR1A, VDR, PTHLH
8
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9.8CALCA, CASR, GNAS, MEN1, PRKAR1A, CDKN1B

Compounds for genes affiliated with Parathyroid Adenoma

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Parathyroid Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 136)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8VDR
2forskolin44 49 1112.7PTH, CALCA, PRKAR1A
3glutamate4410.7CASR, PRKAR1A, GNAS
422-oxacalcitriol4410.6ALPP, PTHLH, VDR, CASR
5calcium carbonate4410.5CALCA, ALPP, PTH, PTHLH
6pamidronate44 49 1112.5ALPP, PTH, CASR, CALCA, PTHLH
7cinacalcet44 28 1112.5CALCA, CASR, PRKAR1A, CXADR
8alendronate44 49 1112.5VDR, CALCA, PTHLH, PTH, ALPP
925-hydroxyvitamin d4410.5CASR, CALCA, VDR, ALPP, PTHLH, PTH
10phosphorus4410.5CALCA, CASR, VDR, PTHLH, PTH, ALPP
11deoxypyridinoline4410.4PTH, VDR, CALCA
12eb 108944 5911.4CCND1, CDKN1B, PTHLH, VDR
13bromodeoxyuridine4410.4FGFR2, PTHLH, CDKN1B, PTH, CCND1, CHGA
14neomycin4410.4CASR, PRKAR1A, ALPP, PTHLH, CXADR
15acth4410.4CASR, GNAS, CHGA, CHGB, LGALS3
16l-amino acid4410.4PRKAR1A, CHGA, CXADR, CASR
17etidronic acid44 49 1112.3ALPP, VDR, CALCA
181,25 dihydroxy vitamin d34410.3CALCA, CASR, ALPP, VDR, CDKN1B, CXADR
19dexamethasone44 49 28 1113.3ALPP, CHGB, ABCB1, VDR, CDKN1B, CXADR
20calcitriol44 59 11 2413.3PTH, ALPP, CASR, VDR, CDKN1B, CALCA
21guanine44 11 2412.3CCND1, GNAS, CHGA, VDR, CALCA, FGFR2
22agar4410.3FGFR2, RET, CDKN1B, PTHLH, CCND1, LGALS3
23ribonucleic acid4410.3PTHLH, RET, FGFR2, CHGA, GNAS, CXADR
24tamoxifen44 49 28 1113.2CDKN1B, FGFR2, ABCB1, CHGA, PTH, ALPP
25paraffin4410.2PTHLH, CHGA, CDKN1B, LGALS3, ALPP, RET
26cyclic amp44 2411.2CDKN1B, PTHLH, GNAS, CASR, RET, CHGA
27steroid4410.2GNAS, PRKAR1A, VDR, FGFR2, CXADR, CCND1
28genistein44 28 59 2 11 2415.2ABCB1, CCND1, CDKN1B, RET, FGFR2, VDR
29progesterone44 59 28 11 2414.2GNAS, PTHLH, ABCB1, FGFR2, CDKN1B, CHGA
30cisplatin44 49 59 1113.2FGFR2, CXADR, ABCB1, PTHLH, LGALS3, CHGA
31thymidine44 2411.2CXADR, ALPP, PTH, PTHLH, MEN1, FGFR2
3224,25-dihydroxyvitamin d34410.1ALPP, VDR, CALCA
33creatinine4410.1PTHLH, ALPP, PTH, CASR, CHGA, VDR
34threonine4410.1CDKN1B, CDKN2C, RET, FGFR2, PTHLH, LGALS3
35nitric oxide44 11 2412.1CXADR, CASR, CHGA, CDKN1B, CALCA, FGFR2
36adenylate4410.1GNAS, CASR, CALCA, CCND1, PRKAR1A, CHGA
37paclitaxel44 49 1112.1CDKN1B, CCND1, ABCB1, CHGA, FGFR2
38serine4410.1CDKN2C, RET, CXADR, CCND1, ALPP, CDKN1B
39vegf4410.1LGALS3, PTH, PTHLH, FGFR2, RET, CDKN1B
40alanine4410.1PTHLH, CASR, GNAS, VDR, ALPP, CDKN1B
41testosterone44 59 11 2413.1FGFR2, CCND1, VDR, CALCA, CHGA, ALPP
42vitamin d4410.0VDR, ALPP, PTHLH, PTH, LGALS3, CXADR
43retinoic acid44 2411.0LGALS3, CXADR, ALPP, PTHLH, CHGA, CCND1
44cycloheximide4410.0ALPP, PTH
45oligonucleotide4410.0CDKN1B, CHGB, RET, GNAS, CCND1, FGFR2
46norepinephrine44 11 2412.0CALCA, PTHLH, CHGB, CHGA, ALPP, GNAS
47cysteine4410.0CXADR, ALPP, CASR, GNAS, LGALS3, FGFR2
48tyrosine449.9CHGA, PTHLH, PTH, LGALS3, FGFR2, RET
49arginine449.9PRKAR1A, CASR, GNAS, CHGA, CDKN1B, ALPP
50calcium44 49 11 2412.8GNAS, CHGA, RET, PRKAR1A, ALPP, VDR

GO Terms for genes affiliated with Parathyroid Adenoma

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16Gene Ontology
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Cellular components related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.9PTHLH, CXADR, FGFR2, CHGB, CHGA, GNAS

Biological processes related to Parathyroid Adenoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1cAMP metabolic processGO:04605810.4PTHLH, PTH
2adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.3CALCA, PTHLH, PTH
3positive regulation of cAMP biosynthetic processGO:03081910.3CALCA, GNAS, PTHLH, PTH
4skeletal system developmentGO:00150110.3LGALS3, PTH, PTHLH, VDR
5negative regulation of cell proliferationGO:00828510.2PTHLH, FGFR2, CDKN2C, CDKN1B, CDC73, VDR
6negative regulation of transcription from RNA polymerase II promoterGO:00012210.1PTH, FGFR2, CDC73, VDR, MEN1
7cell-cell signalingGO:00726710.1PTH, PTHLH, FGFR2, CALCA
8cellular calcium ion homeostasisGO:00687410.0CASR, VDR, PTH

Molecular functions related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.3CDKN2C, CDKN1B
2hormone activityGO:00517910.1CALCA, CHGB, PTHLH, PTH
3peptide hormone receptor bindingGO:05142810.1PTH, PTHLH
4protein bindingGO:0055159.3LGALS3, CCND1, CALCA, CASR, GNAS, MEN1

Products for genes affiliated with Parathyroid Adenoma

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Sources for Parathyroid Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet