MCID: PRT029
MIFTS: 46

Parathyroid Adenoma malady

Genetic diseases, Endocrine diseases, Cancer diseases, Rare diseases categories

Summaries for Parathyroid Adenoma

About this section


Wikipedia:63 A parathyroid adenoma is a benign tumor of the parathyroid gland. It generally causes... more...

MalaCards based summary: Parathyroid Adenoma, also known as adenoma of the parathyroid gland, is related to osteitis fibrosa and hyperparathyroidism-jaw tumor syndrome. An important gene associated with Parathyroid Adenoma is MEN1 (multiple endocrine neoplasia I), and among its related pathways are Endochondral Ossification and Development Hedgehog and PTH signaling pathways in bone and cartilage development. The compounds calcium carbonate and alendronate have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and lymph node, and related mouse phenotypes are digestive/alimentary and integument.

Aliases & Classifications for Parathyroid Adenoma

About this section
Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt
See all sources

Parathyroid Adenoma, Aliases & Descriptions:

Name: Parathyroid Adenoma 9 11 43 60
 
Adenoma of the Parathyroid Gland 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Cancer diseases, Rare diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:7608
MeSH33 D010282
SNOMED-CT55 128474007
NCIt38 C3916

Related Diseases for Parathyroid Adenoma

About this section

Diseases in the Parathyroid Adenoma family:

Familial Parathyroid Adenoma

Diseases related to Parathyroid Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1osteitis fibrosa31.2CASR, PTH
2hyperparathyroidism-jaw tumor syndrome31.1CDC73
3parathyroid carcinoma30.9PTH, MEN1, CASR, CDC73
4adenoma30.8PTH, CHGB, CHGA, MEN1, CASR, CDC73
5hyperparathyroidism30.7PTH, PTHLH, CDC73, CASR, MEN1, CHGA
6multiple endocrine neoplasia iia30.6CDC73, MEN1, PTH
7primary hyperparathyroidism30.6CDC73, CASR, MEN1, CHGA, PTHLH, PTH
8rickets30.4CASR, PTH
9vipoma30.3MEN1, CHGA
10thyroid cancer30.2CHGA, PTH
11osteomalacia30.2PTH, PTHLH, CASR
12hypercalcemia30.1PTH, PTHLH, CHGA, MEN1, CASR, CDC73
13multiple endocrine neoplasia 130.1CDC73, MEN1, CHGA
14pheochromocytoma30.1MEN1, CHGA, CHGB
15multiple endocrine neoplasia30.0CDC73, MEN1, CHGA, CHGB
16paraganglioma29.9CHGB, CHGA, MEN1
17breast cancer29.7PTHLH, CHGB, CHGA
18mediastinitis11.0
19thyroiditis10.9
20cervicitis10.7
21papillary carcinoma10.5
22goiter10.5
23pancreatitis10.4
24familial parathyroid adenoma10.4
25brachydactyly10.4PTH
26acute pancreatitis10.4
27multinodular goiter10.4
28thymoma10.4
29aortopulmonary window10.4
30hyperparathyroidism, familial primary10.3CDC73, MEN1
31follicular adenoma10.3
32laryngitis10.3
33mixed cell type adenoma of parathyroid10.3
34water-clear cell adenoma10.3
35clear cell adenoma10.3
36pseudohypoparathyroidism, type ib10.3PTHLH, PTH
37pseudohypoparathyroidism10.2PTH, PTHLH
38hepatocellular carcinoma10.2
39lung cancer10.2
40renal cell carcinoma10.2
41multiple myeloma10.2
42neurofibromatosis, type 110.2
43neurofibromatosis10.2
44cerebritis10.2
45myeloma10.2
46medullary sponge kidney10.2
47thyroid hemiagenesis10.2
48hypophosphatemia10.2PTHLH, PTH
49osteoporosis10.2PTHLH, PTH
50renal osteodystrophy10.2PTH, CASR

Graphical network of the top 20 diseases related to Parathyroid Adenoma:



Diseases related to parathyroid adenoma

Symptoms for Parathyroid Adenoma

About this section

Drugs & Therapeutics for Parathyroid Adenoma

About this section

Drug clinical trials:

Search ClinicalTrials for Parathyroid Adenoma

Search NIH Clinical Center for Parathyroid Adenoma

Genetic Tests for Parathyroid Adenoma

About this section

Anatomical Context for Parathyroid Adenoma

About this section

MalaCards organs/tissues related to Parathyroid Adenoma:

31
Thyroid, Bone, Lymph node, Lung, Breast, Thymus, Kidney, Eye, Liver, Salivary gland, Testes, Endothelial, Pituitary

Animal Models for Parathyroid Adenoma or affiliated genes

About this section

Publications for Parathyroid Adenoma

About this section

Articles related to Parathyroid Adenoma:

(show top 50)    (show all 618)
idTitleAuthorsYear
1
A rare case of a parathyroid adenoma inside a parathyroid cyst. (25372589)
2014
2
Brown tumor in a patient with ectopic mediastinal parathyroid adenoma: A case report. (25408600)
2014
3
Hemosuccus pancreaticus following Parathyroidectomy for Primary parathyroid adenoma. (25910312)
2014
4
Parathyroid adenoma in third pharyngeal pouch cyst as a rare case of primary hyperparathyroidism. (25245714)
2014
5
Parathyroid adenoma in a patient with familial hypocalciuric hypercalcaemia. (25320261)
2014
6
Ectopic thymic parathyroid adenoma. (25257890)
2014
7
Humeral brown tumor as first presentation of primary hyperparathyroidism caused by ectopic parathyroid adenomas: report of two cases and review of literature. (25400803)
2014
8
Management of ectopic parathyroid adenoma in pregnancy. (25004326)
2014
9
Thoracoscopic removal of ectopic mediastinal parathyroid adenoma. (25207237)
2014
10
Successful Detection and Removal of a Functional Parathyroid Adenoma in a Pony Using Technetium Tc 99m Sestamibi Scintigraphy. (24417704)
2014
11
Intrathymic parathyroid adenoma presenting with seizures. (23550471)
2013
12
The role of single-photon emission computed tomography/computed tomography in localizing parathyroid adenoma. (23660759)
2013
13
Delayed surgery for parathyroid adenoma misdiagnosed as a thyroid nodule and treated with radiofrequency ablation. (24396684)
2013
14
Octreotide uptake in parathyroid adenoma. (23487397)
2012
15
Giant parathyroid adenoma. (22610816)
2011
16
The use of gamma probe for the intraoperative localization of an ectopic parathyroid adenoma. (19714514)
2009
17
Normal parathyroid hormone levels in a diabetic patient with parathyroid adenoma. (19116787)
2009
18
Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism. (19491068)
2009
19
Cervical approach by lifting the superior sternum for mediastinal parathyroid adenoma. (19238073)
2009
20
Tc-99m sestamibi uptake mimicking parathyroid adenoma in a patient with primary hyperparathyroidism and occult multiple myeloma. (18287846)
2008
21
Ectopic parathyroid adenoma in child. (19548602)
2008
22
Intraoperative parathyroid hormone assay improves outcomes of minimally invasive parathyroidectomy mainly in patients with a presumed solitary parathyroid adenoma and missing concordance of preoperative imaging. (17437518)
2007
23
Primary hyperparathyroidism due to parathyroid adenoma. (17268723)
2007
24
Water-clear cell parathyroid adenoma causing primary hyperparathyroidism in a patient with neurofibromatosis type 1: report of a case. (17879040)
2007
25
High resolution MRI in the detection of an intrathymic parathyroid adenoma. (16940365)
2006
26
Intrathyroidal parathyroid adenoma. (15965320)
2005
27
Parathyroid adenoma presenting as paraneoplastic syndrome secondary to renal cell carcinoma. (16048706)
2005
28
A case of Costello with parathyroid adenoma and hyperprolactinemia. (14699620)
2004
29
Distinct target regions for chromosome 1p deletions in parathyroid adenomas and carcinomas. (12239610)
2002
30
Using technetium 99m tetrofosmin parathyroid imaging to detect parathyroid adenoma and its relation to P-glycoprotein expression. (12324759)
2002
31
Large carotid sheath parathyroid adenoma localized by Tc-99m sestamibi. (11139048)
2001
32
Thoracoscopically managed parathyroid adenoma in the upper anterior mediastinum. (11822866)
2001
33
Visual vignette. Hyperparathyroidism due to a parathyroid adenoma. (11441818)
2000
34
Multiple brown tumors simulating bone metastases: a case of parathyroid adenoma coexisting with papillary carcinoma of the thyroid. (11043714)
2000
35
Median sternotomy for parathyroid adenoma. (10098336)
1999
36
Loss of wild-type MEN1 gene expression in multiple endocrine neoplasia type 1-associated parathyroid adenoma. (10580746)
1999
37
The ectopic parathyroid adenoma: a cost justification for routine preoperative localization with technetium Tc 99m sestamibi scan. (9639474)
1998
38
Aspiration cytology of parathyroid adenoma: radioimmunoassay of parathormone in aspirate as a helpful diagnostic tool. (9622722)
1998
39
Papillary thyroid carcinoma, parathyroid adenoma, and unexplained hypercalcitoninemia: an unusual presentation of multiple endocrine neoplasia type 2A? (9777749)
1998
40
Dyshormonogenetic goitre with clear cell change resembling parathyroid adenoma--a case report. (9866911)
1998
41
Parathyroid adenoma, hyperplasia, and carcinoma: localization, technical details of primary neck exploration, and treatment of hypercalcemic crisis. (9735131)
1998
42
You're the flight surgeon. Parathyroid adenoma with primary hyperparathyroidism, recurrent renal calculi, and brown tumor. (9773908)
1998
43
Location of a small mediastinal parathyroid adenoma using Tc-99m MIBI SPECT. (9509943)
1998
44
Kinetics of Tc-99m sestamibi and Tc-99m tetrofosmin in a case of parathyroid adenoma. (8879870)
1996
45
Differences in PTH (1-84) release in response to ambient calcium concentrations of parathyroid adenoma fragments and dispersed parathyroid adenoma cells in culture. (8844452)
1996
46
Persistent elevated serum levels of intact parathyroid hormone after operation for sporadic parathyroid adenoma: evidence of detrimental effects of severe parathyroid disease. (8650602)
1996
47
Absence of cyclin D1/PRAD1 point mutations in human breast cancers and parathyroid adenomas and identification of a new cyclin D1 gene polymorphism. (7621424)
1995
48
Preoperative localization of a parathyroid adenoma with Tc-99m sestamibi imaging in a patient with concomitant nontoxic multinodular goiter. (7895432)
1995
49
Clonal analysis of parathyroid adenomas by means of the polymerase chain reaction. (7910112)
1994
50
Immunohistochemical localization of parathyroid hormone-related protein in parathyroid adenoma and hyperplasia. (2196348)
1990

Variations for Parathyroid Adenoma

About this section

Expression for genes affiliated with Parathyroid Adenoma

About this section
Search GEO for disease gene expression data for Parathyroid Adenoma.

Pathways for genes affiliated with Parathyroid Adenoma

About this section

Pathways related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6PTHLH, PTH
29.6PTHLH, PTH

Compounds for genes affiliated with Parathyroid Adenoma

About this section

Compounds related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

(show all 49)
idCompoundScoreTop Affiliating Genes
1calcium carbonate4310.0PTHLH, PTH
2alendronate43 49 1211.9PTHLH, PTH
3leupeptin439.9PTH, PTHLH
422-oxacalcitriol439.9CASR, PTHLH
5hydroxyproline43 24 1211.9PTHLH, PTH
6bicarbonate439.7PTHLH, PTH
7hydroxyapatite439.7CASR, PTHLH
8ag 1478439.7PTHLH, PTH
9neomycin439.7PTHLH, CASR
10aprotinin43 1210.6PTH, PTHLH
11pamidronate43 49 1211.5PTH, PTHLH, CASR
1225-hydroxyvitamin d439.5PTH, PTHLH, CASR
13thymidine43 2410.5PTH, PTHLH, MEN1
14phosphorus439.5PTH, PTHLH, CASR
151,25 dihydroxy vitamin d3439.5PTH, PTHLH, CASR
16l-amino acid439.5CHGA, CASR
17calcitriol43 59 24 1212.5CASR, PTHLH, PTH
18secretoneurin439.4CHGA, CHGB
19octreotide43 59 28 1212.4CHGA, PTHLH
20peptidylglycine439.4CHGB, CHGA
21acth439.4CHGB, CHGA
22pge2439.4PTH, PTHLH, CASR
23sodium43 2410.3CASR, PTHLH, PTH
24bromodeoxyuridine439.2PTH, PTHLH, CHGA
25isoproterenol43 1210.2CHGA, PTHLH, PTH
26tamoxifen43 49 28 1212.1CHGA, PTHLH, PTH
27catecholamine439.0CHGA, CHGB
28magnesium43 24 1211.0CASR, PTHLH, PTH
29hydrogen43 2410.0CASR, CHGA, PTHLH
30cycloheximide438.9CHGA, PTHLH, PTH
31norepinephrine43 24 1210.9PTHLH, CHGB, CHGA
32potassium43 24 1210.9CASR, CHGB, PTHLH, PTH
33vegf438.8PTH, PTHLH, CHGA, MEN1
34ribonucleic acid438.7PTH, PTHLH, CHGA, CASR
35forskolin43 49 1210.7PTH, PTHLH, CHGA, CASR
36creatinine438.7CASR, CHGA, PTHLH, PTH
37adenylate438.7PTH, PTHLH, CHGA, CASR
38cyclic amp43 249.7CASR, CHGA, PTHLH, PTH
39arginine438.6PTH, PTHLH, CHGA, CASR
40nitric oxide43 24 1210.6PTH, PTHLH, CHGA, CASR
41glucose438.6CASR, CHGA, PTHLH, PTH
42dexamethasone43 49 28 1211.5CHGA, CHGB, PTHLH, PTH
43inositol 1,4,5 trisphosphate438.5CASR, CHGA, CHGB, PTH
44testosterone43 59 24 1211.5CHGA, PTHLH, PTH
45vitamin d438.4CASR, MEN1, CHGA, PTHLH, PTH
46estrogen437.7PTH, PTHLH, CHGB, CHGA, MEN1, CASR
47tyrosine437.7PTH, PTHLH, CHGB, CHGA, MEN1, CASR
48calcium43 49 24 1210.7PTH, PTHLH, CHGB, CHGA, MEN1, CASR
49serine437.6PTHLH, CHGB, CHGA, MEN1, CASR, CDKN2C

GO Terms for genes affiliated with Parathyroid Adenoma

About this section

Cellular components related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301418.7CHGA, CHGB
2extracellular regionGO:00055768.2CHGA, CHGB, PTHLH, PTH

Biological processes related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1osteoblast developmentGO:00020769.8MEN1, PTHLH
2cAMP metabolic processGO:00460589.8PTHLH, PTH
3positive regulation of cAMP biosynthetic processGO:00308199.7PTHLH, PTH
4adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.7PTH, PTHLH
5regulation of gene expressionGO:00104689.6PTHLH, PTH
6negative regulation of sequence-specific DNA binding transcription factor activityGO:00434339.6MEN1, PTHLH
7negative regulation of transcription from RNA polymerase II promoterGO:00001229.3CDC73, MEN1, PTH
8cellular calcium ion homeostasisGO:00068749.2PTH, CASR
9negative regulation of cell proliferationGO:00082859.0PTHLH, MEN1, CDC73, CDKN2C

Molecular functions related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:00514289.6PTHLH, PTH
2hormone activityGO:00051798.7CHGB, PTHLH, PTH

Products for genes affiliated with Parathyroid Adenoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Parathyroid Adenoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet