MCID: PRT029
MIFTS: 56

Parathyroid Adenoma malady

Endocrine diseases category

Summaries for Parathyroid Adenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A parathyroid adenoma is a benign tumor of the parathyroid gland. It generally causes... more...

MalaCards: Parathyroid Adenoma, also known as adenoma of the parathyroid gland, is related to adenoma and hyperparathyroidism. An important gene associated with Parathyroid Adenoma is CDC73 (cell division cycle 73), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Cell cycle. The compounds estrogen and forskolin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and breast, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Aliases & Classifications for Parathyroid Adenoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

parathyroid adenoma 8 10 44 60
adenoma of the parathyroid gland 8


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Disease Ontology8 DOID:7608
NCIt39 C3916
SNOMED-CT56 128474007
MeSH34 D010282

Related Diseases for Parathyroid Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Parathyroid Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma32.0LGALS3, PTH, CXADR, RET, CDKN2C, CDKN1B
2hyperparathyroidism31.4ALPP, PTH, PTHLH, CXADR, RET, CDKN1B
3primary hyperparathyroidism31.4ALPP, PTH, PTHLH, CXADR, RET, CDC73
4parathyroid carcinoma31.2PTH, CXADR, CDC73, MEN1, CASR
5thyroiditis31.2CALCA
6papillary carcinoma30.9LGALS3, RET, CDKN1B, CHGA, GNAS, CALCA
7papillary thyroid carcinoma30.9LGALS3, RET, MEN1, CALCA, CCND1
8hypercalcemia30.9ALPP, PTH, PTHLH, CXADR, CDC73, VDR
9osteitis fibrosa30.7ALPP, PTH, GNAS, CASR
10goiter30.6LGALS3, PTH, RET, GNAS, CALCA
11follicular adenoma30.5LGALS3, RET, GNAS, CALCA
12sarcoidosis30.4ALPP
13pancreatitis30.3ALPP, CASR
14meningioma30.2CXADR, FGFR2, CDKN2C, MEN1
15neurofibromatosis30.2RET
16multiple endocrine neoplasia type 2a30.2PTH, RET, CDC73, MEN1, CALCA
17follicular thyroid carcinoma30.2LGALS3, RET, CALCA
18myeloma30.2ALPP, PTHLH, ABCB1, CDKN2C, CCND1
19pheochromocytoma30.2RET, CHGB, CHGA, MEN1, GNAS, CALCA
20thyroid cancer30.2LGALS3, RET, CDKN1B, GNAS, CASR, CALCA
21thyroid medullary carcinoma30.2LGALS3, RET, CHGB, CHGA, PRKAR1A, MEN1
22breast cancer30.2LGALS3, PTHLH, ABCB1, FGFR2, CDKN1B, CHGB
23hepatocellular carcinoma30.2ALPP, ABCB1, CXADR, FGFR2, CDKN2C, CDKN1B
24multiple myeloma30.2ABCB1, CCND1
25obesity30.0GNAS
26hypertension30.0PTH, CALCA
27vipoma30.0CHGA, MEN1
28hyperthyroidism30.0ALPP, PTH, GNAS
29hypogonadism30.0CALCA
30cholangiocarcinoma30.0ALPP, LGALS3, CDKN1B
31rickets30.0ALPP, PTH, VDR, CASR
32familial medullary thyroid carcinoma30.0RET, CALCA
33hyperprolactinemia30.0PTHLH, GNAS
34hemangioma30.0RET, MEN1
35papilloma30.0CDKN1B
36squamous cell carcinoma30.0LGALS3, PTHLH, CCND1
37nodular goiter30.0LGALS3, RET, CALCA
38paraganglioma30.0RET, CHGB, CHGA, MEN1, CALCA
39ossifying fibroma30.0CDC73
40astrocytoma30.0LGALS3, CXADR, FGFR2, CDKN1B, CASR
41diabetes mellitus30.0ALPP, PTH, VDR, CASR, CALCA
42chondrosarcoma30.0PTHLH, FGFR2
43osteomalacia30.0ALPP, PTH, PTHLH, VDR, GNAS, CASR
44lung cancer30.0PTHLH, ABCB1, CXADR, CHGA
45pituitary adenoma30.0LGALS3, FGFR2, RET, CDKN1B, CHGB, CHGA
46mediastinitis10.9
47papillary adenoma10.6
48cervicitis10.6
49oxyphilic adenoma10.4
50multinodular goiter10.4

Graphical network of the top 20 diseases related to Parathyroid Adenoma:



Diseases related to parathyroid adenoma

Clinical Features for Parathyroid Adenoma

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Drugs & Therapeutics for Parathyroid Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Parathyroid Adenoma

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Anatomical Context for Parathyroid Adenoma

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32MalaCards
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MalaCards organs/tissues related to Parathyroid Adenoma:

32
Thyroid, Bone, Breast, Pituitary, Lymph node, Kidney, Thymus, Lung, Liver, Salivary gland, Testes

Animal Models for Parathyroid Adenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Parathyroid Adenoma:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537710.3CDKN1B, GNAS
2MP:000536710.2CASR, GNAS, CHGA, CDC73, RET, FGFR2
3MP:000537510.2GNAS, PRKAR1A, CDC73
4MP:000536910.1CASR, MEN1, PRKAR1A, VDR, CDC73, RET
5MP:000539010.1CCND1, GNAS, PRKAR1A, FGFR2, PTHLH, LGALS3
6MP:000537910.1CXADR, FGFR2, RET, CDKN2C, CDKN1B, CDC73
7MP:000363110.1GNAS, CHGB, VDR, CDC73, RET, FGFR2
8MP:000538810.1CCND1, GNAS, PRKAR1A, CDKN1B, CDKN2C, FGFR2
9MP:000538910.0CCND1, MEN1, PRKAR1A, VDR, CDC73, CDKN1B
10MP:001077110.0CCND1, CALCA, CASR, GNAS, VDR, CDC73
11MP:000537010.0ABCB1, FGFR2, CDKN1B, CDC73, MEN1, GNAS
12MP:000538210.0CCND1, GNAS, MEN1, PRKAR1A, VDR, CDKN1B
13MP:00020069.9CCND1, CALCA, MEN1, PRKAR1A, CDKN1B, CDKN2C
14MP:00053769.9PRKAR1A, MEN1, GNAS, CASR, CALCA, CHGB
15MP:00053819.9VDR, PRKAR1A, MEN1, CASR, CCND1, CDC73
16MP:00053869.7VDR, GNAS, CASR, CALCA, CCND1, CDC73
17MP:00053809.7PRKAR1A, CDC73, RET, FGFR2, CXADR, ALPP
18MP:00053979.7CDC73, VDR, PRKAR1A, GNAS, CASR, CCND1
19MP:00053789.6CHGA, PRKAR1A, MEN1, GNAS, CASR, CCND1
20MP:00053879.6CDC73, VDR, PRKAR1A, MEN1, GNAS, CASR
21MP:00053849.6VDR, PRKAR1A, MEN1, GNAS, CASR, CCND1
22MP:00053859.6LGALS3, CALCA, CCND1, GNAS, MEN1, PTH
23MP:00107689.4VDR, CHGA, PRKAR1A, MEN1, GNAS, CASR

Publications for Parathyroid Adenoma

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50PubMed
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Articles related to Parathyroid Adenoma:

(show top 50)    (show all 614)
idTitleAuthorsYear
1
Predictors of accuracy in preoperative parathyroid adenoma localization using ultrasound and Tc-99m-Sestamibi: a 4-quadrant analysis. (23759694)
2013
2
Percutaneous sonographically-guided radiofrequency ablation in the management of parathyroid adenoma. (23665699)
2013
3
Spectral Doppler analysis of parathyroid adenoma: correlation between resistive index and serum parathyroid hormone concentration. (23883247)
2013
4
Intraoperative 3-D mapping of parathyroid adenoma using freehand SPECT. (23014191)
2012
5
A challenging case of an ectopic parathyroid adenoma. (23565445)
2012
6
A rare S33C mutation of CTNNB1 encoding I^-catenin in a parathyroid adenoma found in an Italian primary hyperparathyroid cohort. (22095489)
2012
7
Hungry bone disease in a pregnant woman with parathyroid adenoma. (22837946)
2012
8
Sensitivity of HRPT2 mutation screening to detect parathyroid carcinoma and atypical parathyroid adenoma of Thai patients. (21717873)
2011
9
MRI localization of mildly symptomatic ectopic retropharyngeal parathyroid adenoma: the impact on surgical approach. A case report. (24059902)
2011
10
Fluorodeoxyglucose-avid parathyroid adenoma mimicking thyroid incidentaloma. (21040351)
2010
11
Cervical approach by lifting the superior sternum for mediastinal parathyroid adenoma. (19238073)
2009
12
Reoperation for parathyroid adenoma: a contemporary experience. (19958942)
2009
13
Association of parathyroid adenoma and familial hypocalciuric hypercalcaemia in a teenager. (19423559)
2009
14
Ectopic mediastinal parathyroid adenoma: a cause of acute pancreatitis. (19598003)
2009
15
Radio-guided thoracoscopic surgery with (99m)Tc-methoxy-isobutylisonitrile for treating an ectopic mediastinal parathyroid adenoma in an adolescent girl. (20013101)
2009
16
Neck emergency due to parathyroid adenoma bleeding: a case report. (19830200)
2009
17
Prolonged hungry bone syndrome in a 10-year-old child with parathyroid adenoma. (19242040)
2009
18
Dual-phase 99mTc-MIBI parathyroid imaging reveals synchronous parathyroid adenoma and papillary thyroid carcinoma: a case report. (19181586)
2008
19
Impact of adenoma weight and ectopic location of parathyroid adenoma on localization study results. (18210183)
2008
20
Giant posterior mediastinal parathyroid adenoma. (18399771)
2008
21
Primary hyperparathyroidism due to parathyroid adenoma. (17268723)
2007
22
Benign parathyroid adenoma presenting with unusual parathyroid crisis, anemia and myelofibrosis. (17493890)
2007
23
Sestamibi scan-directed, minimally invasive video-assisted parathyroidectomy: an effective treatment for solitary parathyroid adenoma. (17724570)
2007
24
Intrathyroid parathyroid adenoma in primary hyperparathyroidism: can it be predicted preoperatively? (17354026)
2007
25
Loss of nuclear expression of parafibromin distinguishes parathyroid carcinomas and hyperparathyroidism-jaw tumor (HPT-JT) syndrome-related adenomas from sporadic parathyroid adenomas and hyperplasias. (16931959)
2006
26
Parathyroid adenoma localization: surgeon-performed ultrasound versus sestamibi. (16885740)
2006
27
Demonstration of an ectopic mediastinal parathyroid adenoma on Tc-99m sestamibi myocardial perfusion scintigraphy. (16945752)
2006
28
A case of primary hyperparathyrodism due to parathyroid adenoma Doppler ultrasound diagnosis. (17370440)
2006
29
Expression of nitric oxide synthases in parathyroid gland adenoma and parathyroid gland hyperplasia. (16136006)
2005
30
Thoracoscopic resection of a mediastinal intrathymic parathyroid adenoma. (16447483)
2005
31
Distinction in gene expression profiles demonstrated in parathyroid adenomas by high-density oligoarray technology. (15757864)
2005
32
Intraoperative measurement of parathyroid hormone in minimally invasive surgery for parathyroid adenoma. (15515656)
2004
33
Ectopic paraesophageal mediastinal parathyroid adenoma, a rare cause of acute pancreatitis. (15571624)
2004
34
Coexistence of a parathyroid adenoma and parathyroid cyst causing primary hyperparathyroidism. (14594122)
2003
35
Marked uptake of technetium-99m pertechnetate by parathyroid adenoma. (11446675)
2001
36
Non-secreting atypical parathyroid adenoma. (11263467)
2001
37
Effect of parathyroid adenoma resection on bone density in primary hyperparathyroidism and osteitis fibrosa cystica. (11688767)
2001
38
Cloning and characterization of two promoters for the human calcium-sensing receptor (CaSR) and changes of CaSR expression in parathyroid adenomas. (10713061)
2000
39
Supernumerary mediastinal parathyroid adenoma: role of 99mTc sestamibi scanning. (10636556)
1999
40
Unsuspected intrathyroidal parathyroid adenoma: mimic of lymphocytic thyroiditis in fine-needle aspiration specimens-a case report. (10495322)
1999
41
Aspiration cytology of parathyroid adenoma: radioimmunoassay of parathormone in aspirate as a helpful diagnostic tool. (9622722)
1998
42
Intraoperative use of methylene blue to localize parathyroid adenoma. (9591562)
1998
43
Nuclear area measurements of parathyroid adenoma, parathyroid hyperplasia and thyroid follicular adenoma. A comparison. (9051185)
1997
44
Remission of non-insulin-dependent diabetes mellitus following resection of a parathyroid adenoma. (9017358)
1997
45
Extracapsular haemorrhage from a parathyroid adenoma presenting as a massive cervical haematoma. (9231101)
1997
46
High-resolution ultrasonography: highly sensitive, specific technique for preoperative localization of parathyroid adenoma in the absence of multinodular thyroid disease. (9015172)
1997
47
Technetium-99m-methoxyisobutylisonitrile in localization of ectopic parathyroid adenoma. (8691254)
1996
48
Tc-99m sestamibi SPECT imaging of a retroesophageal parathyroid adenoma. (8922853)
1996
49
Concurrent Plummer's disease and parathyroid adenoma. Diagnostic and therapeutic approaches to a difficult clinical problem. (8062469)
1994
50
Osteitis fibrosa cystica secondary to parathyroid adenoma with normocalcemia. (6460745)
1982

Genetic Variations for Parathyroid Adenoma

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Expression for genes affiliated with Parathyroid Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Parathyroid Adenoma

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Pathways for genes affiliated with Parathyroid Adenoma

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12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 4Cell Signaling Technology
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Pathways related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.3PTH, VDR
2
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10.3MEN1, CDKN1B, CDKN2C
3
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10.3CDKN2C, CDKN1B, CCND1
4
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10.2CDKN2C, CDKN1B, CDC73, CCND1
5
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10.2CCND1, CDKN1B, CDKN2C, FGFR2
6
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10.2CDKN1B, VDR, PRKAR1A, GNAS
7
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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10.0PTH, CCND1, GNAS, PRKAR1A, VDR, PTHLH
8
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9.8CALCA, CASR, GNAS, MEN1, PRKAR1A, CDKN1B

Compounds for genes affiliated with Parathyroid Adenoma

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Parathyroid Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 136)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8VDR
2forskolin44 49 1112.7PTH, CALCA, PRKAR1A
3glutamate4410.7CASR, PRKAR1A, GNAS
422-oxacalcitriol4410.6ALPP, PTHLH, VDR, CASR
5calcium carbonate4410.5CALCA, ALPP, PTH, PTHLH
6pamidronate44 49 1112.5ALPP, PTH, CASR, CALCA, PTHLH
7cinacalcet44 28 1112.5CALCA, CASR, PRKAR1A, CXADR
8alendronate44 49 1112.5VDR, CALCA, PTHLH, PTH, ALPP
925-hydroxyvitamin d4410.5CASR, CALCA, VDR, ALPP, PTHLH, PTH
10phosphorus4410.5CALCA, CASR, VDR, PTHLH, PTH, ALPP
11deoxypyridinoline4410.4PTH, VDR, CALCA
12eb 108944 5911.4CCND1, CDKN1B, PTHLH, VDR
13bromodeoxyuridine4410.4FGFR2, PTHLH, CDKN1B, PTH, CCND1, CHGA
14neomycin4410.4CASR, PRKAR1A, ALPP, PTHLH, CXADR
15acth4410.4CASR, GNAS, CHGA, CHGB, LGALS3
16l-amino acid4410.4PRKAR1A, CHGA, CXADR, CASR
17etidronic acid44 49 1112.3ALPP, VDR, CALCA
181,25 dihydroxy vitamin d34410.3CALCA, CASR, ALPP, VDR, CDKN1B, CXADR
19dexamethasone44 49 28 1113.3ALPP, CHGB, ABCB1, VDR, CDKN1B, CXADR
20calcitriol44 59 11 2413.3PTH, ALPP, CASR, VDR, CDKN1B, CALCA
21guanine44 11 2412.3CCND1, GNAS, CHGA, VDR, CALCA, FGFR2
22agar4410.3FGFR2, RET, CDKN1B, PTHLH, CCND1, LGALS3
23ribonucleic acid4410.3PTHLH, RET, FGFR2, CHGA, GNAS, CXADR
24tamoxifen44 49 28 1113.2CDKN1B, FGFR2, ABCB1, CHGA, PTH, ALPP
25paraffin4410.2PTHLH, CHGA, CDKN1B, LGALS3, ALPP, RET
26cyclic amp44 2411.2CDKN1B, PTHLH, GNAS, CASR, RET, CHGA
27steroid4410.2GNAS, PRKAR1A, VDR, FGFR2, CXADR, CCND1
28genistein44 28 59 2 11 2415.2ABCB1, CCND1, CDKN1B, RET, FGFR2, VDR
29progesterone44 59 28 11 2414.2GNAS, PTHLH, ABCB1, FGFR2, CDKN1B, CHGA
30cisplatin44 49 59 1113.2FGFR2, CXADR, ABCB1, PTHLH, LGALS3, CHGA
31thymidine44 2411.2CXADR, ALPP, PTH, PTHLH, MEN1, FGFR2
3224,25-dihydroxyvitamin d34410.1ALPP, VDR, CALCA
33creatinine4410.1PTHLH, ALPP, PTH, CASR, CHGA, VDR
34threonine4410.1CDKN1B, CDKN2C, RET, FGFR2, PTHLH, LGALS3
35nitric oxide44 11 2412.1CXADR, CASR, CHGA, CDKN1B, CALCA, FGFR2
36adenylate4410.1GNAS, CASR, CALCA, CCND1, PRKAR1A, CHGA
37paclitaxel44 49 1112.1CDKN1B, CCND1, ABCB1, CHGA, FGFR2
38serine4410.1CDKN2C, RET, CXADR, CCND1, ALPP, CDKN1B
39vegf4410.1LGALS3, PTH, PTHLH, FGFR2, RET, CDKN1B
40alanine4410.1PTHLH, CASR, GNAS, VDR, ALPP, CDKN1B
41testosterone44 59 11 2413.1FGFR2, CCND1, VDR, CALCA, CHGA, ALPP
42vitamin d4410.0VDR, ALPP, PTHLH, PTH, LGALS3, CXADR
43retinoic acid44 2411.0LGALS3, CXADR, ALPP, PTHLH, CHGA, CCND1
44cycloheximide4410.0ALPP, PTH
45oligonucleotide4410.0CDKN1B, CHGB, RET, GNAS, CCND1, FGFR2
46norepinephrine44 11 2412.0CALCA, PTHLH, CHGB, CHGA, ALPP, GNAS
47cysteine4410.0CXADR, ALPP, CASR, GNAS, LGALS3, FGFR2
48tyrosine449.9CHGA, PTHLH, PTH, LGALS3, FGFR2, RET
49arginine449.9PRKAR1A, CASR, GNAS, CHGA, CDKN1B, ALPP
50calcium44 49 11 2412.8GNAS, CHGA, RET, PRKAR1A, ALPP, VDR

GO Terms for genes affiliated with Parathyroid Adenoma

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16Gene Ontology
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Cellular components related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.9PTHLH, CXADR, FGFR2, CHGB, CHGA, GNAS

Biological processes related to Parathyroid Adenoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1cAMP metabolic processGO:04605810.4PTHLH, PTH
2adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.3CALCA, PTHLH, PTH
3positive regulation of cAMP biosynthetic processGO:03081910.3CALCA, GNAS, PTHLH, PTH
4skeletal system developmentGO:00150110.3LGALS3, PTH, PTHLH, VDR
5negative regulation of cell proliferationGO:00828510.2PTHLH, FGFR2, CDKN2C, CDKN1B, CDC73, VDR
6negative regulation of transcription from RNA polymerase II promoterGO:00012210.1PTH, FGFR2, CDC73, VDR, MEN1
7cell-cell signalingGO:00726710.1PTH, PTHLH, FGFR2, CALCA
8cellular calcium ion homeostasisGO:00687410.0CASR, VDR, PTH

Molecular functions related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.3CDKN2C, CDKN1B
2hormone activityGO:00517910.1CALCA, CHGB, PTHLH, PTH
3peptide hormone receptor bindingGO:05142810.1PTH, PTHLH
4protein bindingGO:0055159.3LGALS3, CCND1, CALCA, CASR, GNAS, MEN1

Products for genes affiliated with Parathyroid Adenoma

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  • Antibodies
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Sources for Parathyroid Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet