MCID: PRT029
MIFTS: 48

Parathyroid Adenoma malady

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Parathyroid Adenoma

Aliases & Descriptions for Parathyroid Adenoma:

Name: Parathyroid Adenoma 12 52 14 69
Adenoma of Parathyroid 12 29
Adenoma of the Parathyroid Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7608
MeSH 42 D010282
NCIt 47 C3916
SNOMED-CT 64 128474007
UMLS 69 C0262587

Summaries for Parathyroid Adenoma

MalaCards based summary : Parathyroid Adenoma, also known as adenoma of parathyroid, is related to hyperparathyroidism, familial primary and parathyroid carcinoma. An important gene associated with Parathyroid Adenoma is CCND1 (Cyclin D1), and among its related pathways/superpathways are DNA Damage and Cell cycle. The drugs Denosumab and vitamin d have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and breast, and related phenotypes are endocrine/exocrine gland and cardiovascular system

Wikipedia : 71 A parathyroid adenoma is a benign tumor of the parathyroid gland. It generally causes... more...

Related Diseases for Parathyroid Adenoma

Diseases related to Parathyroid Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
id Related Disease Score Top Affiliating Genes
1 hyperparathyroidism, familial primary 31.3 CASR CCND1 CDC73 MEN1 RET
2 parathyroid carcinoma 30.7 CASR CDC73 CHGA GCM2 MEN1 PTH
3 pheochromocytoma 29.4 CHGA MEN1 RET
4 mixed cell type adenoma of parathyroid 12.0
5 birt-hogg-dube syndrome 11.2
6 adenoma 11.0
7 chief cell adenoma 10.9
8 hyperparathyroidism-jaw tumor syndrome 10.9
9 multiple endocrine neoplasia iia 10.9
10 hyperparathyroidism 10.6
11 mediastinitis 10.5
12 thyroiditis 10.5
13 restless legs syndrome 7 10.3 CDC73 MEN1
14 cervicitis 10.2
15 macular holes 10.2 MEN1 PTH
16 striatonigral degeneration 10.2 CASR PTH
17 mesenchymal cell neoplasm 10.2 CASR PTH
18 cerebrooculofacioskeletal syndrome 4 10.2 CASR PTHLH
19 toxicodendron dermatitis 10.2 PTH PTHLH
20 mixed germ cell cancer 10.2 PTH PTHLH
21 opthalmoplegia mental retardation lingua scrotalis 10.2 PTH PTHLH
22 bowen-conradi syndrome 10.2 CDKN2C MEN1
23 gastric antral vascular ectasia 10.2 CASR PTH
24 macrocephaly/megalencephaly syndrome, autosomal recessive 10.2 GCM2 PTH
25 deafness, autosomal recessive 42 10.2 CASR GCM2
26 neuroretinitis 10.1 CCND1 MEN1
27 pes anserinus tendinitis or bursitis 10.1 CASR PTH
28 obesity, severe bmiq9 10.1 PTH PTHLH
29 prune belly syndome 10.1 GCM2 PTH
30 impotence 10.1 PTH PTHLH
31 familial chronic myelocytic leukemia-like syndrome 10.1 CASR CDC73 PTH
32 early-onset parkinson disease 10.1 MEN1 RET
33 osteitis fibrosa 10.1
34 hirschsprung disease 1 10.1 MEN1 RET
35 immune system organ benign neoplasm 10.1 CDC73 MEN1 PTH
36 waardenburg syndrome, type 4b 10.1 CASR PTH PTHLH
37 pre-eclampsia 10.1 CASR PTH PTHLH
38 indian tick typhus 10.1 CASR PTH PTHLH
39 goiter 10.1
40 strabismus 10.1 MEN1 PTH PTHLH
41 toenail dystrophy, isolated 10.0 PTH PTHLH
42 weill-marchesani syndrome 10.0 CASR GCM2 PTH
43 intracranial thrombosis 10.0 PTH PTHLH
44 papillary carcinoma 10.0
45 pancreatitis 10.0
46 mitochondrial complex ii deficiency 10.0 CHGA MEN1
47 progressive relapsing multiple sclerosis 10.0 CHGA MEN1
48 dysgerminoma of ovary 10.0 CHGA MEN1
49 pigmented villonodular synovitis 10.0 CHGA PTHLH
50 acute pyelonephritis 10.0 CHGA MEN1

Graphical network of the top 20 diseases related to Parathyroid Adenoma:



Diseases related to Parathyroid Adenoma

Symptoms & Phenotypes for Parathyroid Adenoma

MGI Mouse Phenotypes related to Parathyroid Adenoma:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.18 CASR CCND1 CDC73 CDKN2C CHGA GCM2
2 cardiovascular system MP:0005385 10.14 PTH PTHLH RET CCND1 CDC73 CDKN2C
3 cellular MP:0005384 10.13 CASR CCND1 CDC73 CDKN2C GCM2 MEN1
4 growth/size/body region MP:0005378 10.11 CASR CCND1 CDC73 CDKN2C CHGA MEN1
5 homeostasis/metabolism MP:0005376 10.1 CHGA GCM2 MEN1 PTH PTHLH RET
6 mortality/aging MP:0010768 10.02 CASR CCND1 CDC73 CDKN2C CHGA GCM2
7 hematopoietic system MP:0005397 9.98 CASR CCND1 CDC73 CDKN2C PTH PTHLH
8 digestive/alimentary MP:0005381 9.97 CCND1 CDC73 MEN1 PTHLH RET CASR
9 immune system MP:0005387 9.97 CASR CCND1 CDC73 CDKN2C MEN1 PTH
10 craniofacial MP:0005382 9.91 CCND1 GCM2 MEN1 PTH PTHLH
11 nervous system MP:0003631 9.8 GCM2 MEN1 PTHLH RET CCND1 CDC73
12 renal/urinary system MP:0005367 9.7 CASR CDC73 CDKN2C CHGA GCM2 PTHLH
13 reproductive system MP:0005389 9.5 CDKN2C CHGA MEN1 PTHLH RET CCND1
14 respiratory system MP:0005388 9.02 CCND1 CDC73 CDKN2C PTHLH RET

Drugs & Therapeutics for Parathyroid Adenoma

Drugs for Parathyroid Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 3 615258-40-7
2 vitamin d Phase 3
3 Vitamins Phase 3
4 Bone Density Conservation Agents Phase 3
5 Calcium, Dietary Phase 3
6 Hormones Phase 3
7 Hormone Antagonists Phase 3
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
9 Cinacalcet Hydrochloride Phase 3
10 Calcimimetic Agents Phase 3
11
Choline Approved, Nutraceutical Phase 2 62-49-7 305
12 Gastrointestinal Agents Phase 2
13 Nootropic Agents Phase 2
14 Hypolipidemic Agents Phase 2
15 Lipid Regulating Agents Phase 2
16 Antimetabolites Phase 2
17
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
18
Carboplatin Approved Phase 1 41575-94-4 10339178 498142 38904
19
Trastuzumab Approved, Investigational Phase 1 180288-69-1 9903
20 Adjuvants, Immunologic Phase 1
21 Albumin-Bound Paclitaxel Phase 1
22 Angiogenesis Inhibitors Phase 1
23 Angiogenesis Modulating Agents Phase 1
24 Interleukin-12 Phase 1
25 Antimitotic Agents Phase 1
26 Antineoplastic Agents, Phytogenic Phase 1
27
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
28 Trace Elements
29 Micronutrients
30 Anesthetics
31 Calcitonin Gene-Related Peptide
32 calcitonin

Interventional clinical trials:

(show all 22)
id Name Status NCT ID Phase
1 Treatment of Primary Hyperparathyroidism With Denosumab and Cinacalcet. Not yet recruiting NCT03027557 Phase 3
2 Interest of the F18-choline as a Second Line of the Tracer for Detection of Parathyroid Adenomas Recruiting NCT02432599 Phase 2
3 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
4 Input of C11-Choline PET/CT in Localization of Parathyroid Adenoma Unknown status NCT01221896
5 Evaluation of a New CZT System Unknown status NCT01084356
6 Differentially Expressed Proteins in Sporadic Parathyroid Tumors Unknown status NCT01647503
7 Regulation of Vitamin D Receptor (VDR),Calcium Sensing Receptor (CaSR), Cyclin D1,Ki67 and Proliferating Cell Nuclear Antigen (PCNA) in Primary Hyperparathyroidism Unknown status NCT01228786
8 Surgical Approach for Primary Hyperparathyroidism in the Elderly Unknown status NCT01484379
9 The ISET (Isolation by Size of Epithelial Tumor Cells) and the CellSearch Methods in Malignant Pleural Mesothelioma Unknown status NCT01776385
10 Observation of Histological Changes in Parathyroid Adenomas Following High Intensity Focused Ultrasound (HIFU) Treatment Procedure Completed NCT01060982
11 Using X-Ray Dye to Locate Hidden Parathyroid Tumors Completed NCT00001394
12 Minimally Invasive Radioguided Parathyroidectomy Completed NCT01530919
13 Open Versus Video-Assisted Minimal-Invasive Parathyroid Surgery Completed NCT00877981
14 Anti-3-[18F]FACBC Imaging of Parathyroid Adenomas Recruiting NCT01574287
15 Omission of Intact Parathyroid Hormone Testing During Surgery in Treating Patients With Primary Hyperparathyroidism Recruiting NCT03011736
16 Molecular and IHC Profiling of PTH Tumors to Evaluate Targeted Agents Recruiting NCT03039439
17 Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism. Recruiting NCT03091140
18 Variables That Are Correlated to Developing Multiple Endocrine Neoplasia (MEN) and Pancreatic Neuroendocrine Tumors (PNET) Recruiting NCT03053999
19 Localization of Parathyroid Adenoma by Fluorocholine PET/MRI (Positron Emission Tomography -MRI) Not yet recruiting NCT02843542
20 High Intensity Focused Ultrasound (HIFU) for Parathyroid Adenoma Terminated NCT01291498
21 Evaluation of MRI and SPECT Fusion Software to Localize Parathyroid Adenomas Terminated NCT00639405
22 Multicenter Registry Comparing Preoperative Imaging for Primary Hyperparathyroidism Withdrawn NCT02381925

Search NIH Clinical Center for Parathyroid Adenoma

Genetic Tests for Parathyroid Adenoma

Genetic tests related to Parathyroid Adenoma:

id Genetic test Affiliating Genes
1 Parathyroid Adenoma 29

Anatomical Context for Parathyroid Adenoma

MalaCards organs/tissues related to Parathyroid Adenoma:

39
Thyroid, Bone, Breast, Lymph Node, Lung, Kidney, Thymus

Publications for Parathyroid Adenoma

Articles related to Parathyroid Adenoma:

(show top 50) (show all 697)
id Title Authors Year
1
Giant parathyroid adenoma: differential aspects compared to parathyroid carcinoma. ( 28491324 )
2017
2
Protean Presentations of Parathyroid Adenoma in Childhood. ( 28082776 )
2017
3
A case report of mediastinal ectopic parathyroid adenoma presented as parathyroid crisis localized by SPECT/CT. ( 27741147 )
2016
4
Video Assisted Thoracoscopic Surgery (VATS) for Excision of an Ectopic Anterior Mediastinal Intra-Thymic Parathyroid Adenoma. ( 27504353 )
2016
5
Parathyroid adenoma arising within the sternocleidomastoid muscle: a rare complication of autotransplantation. ( 27440844 )
2016
6
Ultrasound-Guided Percutaneous Microwave Ablation of Parathyroid Adenoma. ( 27886957 )
2016
7
Parathyroid Adenoma Completely Impacted within the Thyroid Gland: A Case Report. ( 27504318 )
2016
8
Mediastinal giant parathyroid adenoma-a minimally invasive mediastinal surgical approach for an emergency presentation. ( 26904438 )
2016
9
5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma. ( 26973719 )
2016
10
Primary Hyperparathyroidism Through an Ectopic Parathyroid Adenoma. ( 27172530 )
2016
11
Surgical treatment for mediastinal parathyroid adenoma causing primary hyperparathyroidism. ( 27056365 )
2016
12
Allocation of parathyroid adenoma and suspicious thyroid nodule by real-time (99m)Tc-MIBI SPECT/US fusion imaging. ( 27259507 )
2016
13
Value of CT Density Measurements in Distinguishing Parathyroid Adenoma,Thyroid,and Lymph Node. ( 27469918 )
2016
14
Shear wave elastography and parathyroid adenoma: A new tool for diagnosing parathyroid adenomas. ( 27501893 )
2016
15
A Rare Case of Concomitant Maxilla and Mandible Brown Tumours, Papillary Thyroid Carcinoma, Parathyroid Adenoma, and Osteitis Fibrosa Cystica. ( 26881146 )
2016
16
Cervical vagus nerve neurilemmoma mimicking parathyroid adenoma. ( 27562903 )
2016
17
Multiple Brown Tumors Caused by a Parathyroid Adenoma Mimicking Metastatic Bone Disease from Giant Cell Tumor. ( 26912981 )
2016
18
Uncommon association of cerebral meningioma, parathyroid adenoma and papillary thyroid carcinoma in a patient harbouring a rare germline variant in the CDKN1B gene. ( 26762354 )
2016
19
(11)C-Methionine positron emission tomography-computed tomography in localization of methoxyisobutyl isonitrile negative ectopic parathyroid adenoma. ( 26917896 )
2016
20
Ectopic Intrathymic Parathyroid adenoma demonstrated on Tc-99m Sestamibi SPECT-CT. ( 27250890 )
2016
21
Methylene blue and parathyroid adenoma localization: Three new cases of a rare cutaneous complication. ( 26930332 )
2016
22
Childhood parathyroid adenoma: a rare but important cause of nephrolithiasis. ( 27054596 )
2016
23
The diagnostic and therapeutic challenges in the management of a double giant parathyroid adenoma. ( 27833320 )
2016
24
Acute presentation of a giant intrathyroidal parathyroid adenoma: a case report. ( 27756436 )
2016
25
Detection of Synchronous Parathyroid Adenoma and Breast Cancer with (18)F-Fluorocholine PET-CT. ( 27275374 )
2016
26
Intrathyroidal parathyroid adenoma: Diagnostic pitfalls on fine-needle aspiration: Two case reports and literature review. ( 27392021 )
2016
27
Mediastinal parathyroid adenoma removal by video assisted thoracoscopic surgery. ( 27728204 )
2016
28
Parathyroid adenoma: a comprehensive biochemical and histological correlative study. ( 27696726 )
2016
29
Resection of a large ectopic parathyroid adenoma: A case report. ( 27078868 )
2016
30
Challenging neck mass: non-functional giant parathyroid adenoma. ( 27535730 )
2016
31
Results of intraoperative gamma probe survey and frozen section in surgical treatment of parathyroid adenoma in children. ( 27132540 )
2016
32
Intrathyroid salivary adenocartinoma not otherwise specified and parathyroid adenoma in multinodular goiter. ( 27055746 )
2016
33
Huge Parathyroid Adenoma with Dysphagia Presentation; A Case Report from Southern Iran. ( 27582595 )
2016
34
Multiple endocrine neoplasia type 1 with anterior mediastinal parathyroid adenoma: successful localization using Tc-99m sestamibi SPECT/CT. ( 27904855 )
2016
35
Non-functioning parathyroid adenoma: a rare differential diagnosis for vocal-cord paralysis. ( 27055408 )
2016
36
Multiple endocrine neoplasia similar to human subtype 2A in a dog: Medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma. ( 27822452 )
2016
37
Utility of (18)F-choline photon emission tomography/computed tomography in the diagnosis of parathyroid adenoma. ( 27385893 )
2016
38
Ectopic parathyroid adenoma in the soft palate: a case report. ( 27756384 )
2016
39
Synchronous parathyroid adenoma and papillary thyroid cancer detected on (99m)Tc-sestamibi scintigraphy. ( 27867896 )
2016
40
Ectopic parathyroid adenoma presenting as facial expansile growths. ( 27097397 )
2016
41
Combined transcervical and thoracoscopic mediastinal parathyroid adenoma resection. ( 27206778 )
2016
42
Excision of middle mediastinal parathyroid adenoma by videoscopic assisted mediastinoscopy (VAM). ( 27747020 )
2016
43
Outcomes of minimally invasive parathyroidectomy in pediatric patients with primary hyperparathyroidism owing to parathyroid adenoma: A single institution experience. ( 26898682 )
2016
44
Erratum: Utility of 18F choline photon emission tomography/computed tomography in the diagnosis of parathyroid adenoma. ( 27833332 )
2016
45
A rare case of double parathyroid adenoma evidenced by (99m)Tc-sestaMIBI SPECT/CT. ( 26992641 )
2016
46
Hybrid-fusion SPECT/CT systems in parathyroid adenoma: Technological improvements and added clinical diagnostic value. ( 27554661 )
2016
47
Unusual Ectopic Parathyroid Adenoma: A Case Report. ( 27701727 )
2016
48
Parathyroid Adenoma Associated with Granulomatous Inflammation: A Curious Cause of Hypercalcaemia. ( 27190821 )
2016
49
A rare case of giant parathyroid adenoma presenting with recurrent episodes of pancreatitis. ( 26917892 )
2016
50
Variable sonographic spectrum of parathyroid adenoma with a novel ultrasound finding: dual concentric echo sign. ( 26052562 )
2015

Variations for Parathyroid Adenoma

ClinVar genetic disease variations for Parathyroid Adenoma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 CDC73 CDC73, 4-BP DEL, 685AGAG deletion Pathogenic
2 MEN1 NM_000244.3(MEN1): c.669+1delG deletion Pathogenic rs1057518903 GRCh38 Chromosome 11, 64807890: 64807890

Copy number variations for Parathyroid Adenoma from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 25580 1 191357783 191487679 Loss HRPT2 Parathyroid adenoma
2 33979 1 51206195 51212897 Loss CDKN2C Parathyroid adenoma
3 33993 1 51300000 56200000 Loss RNF11 Parathyroid adenoma
4 48482 11 1 48800000 Losse MEN1 Parathyroid adenoma
5 192952 5 121500000 127300000 Gaine LMNB1 Parathyroid adenoma
6 192953 5 121500000 127300000 Gaine PIK3R1 Parathyroid adenoma

Expression for Parathyroid Adenoma

Search GEO for disease gene expression data for Parathyroid Adenoma.

Pathways for Parathyroid Adenoma

Pathways related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.9 CCND1 CDC73 CDKN2C
2 11.69 CCND1 CDKN2C MEN1
3 10.42 CCND1 RET
4 10.39 CCND1 PTH PTHLH

GO Terms for Parathyroid Adenoma

Biological processes related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.8 CCND1 CDC73 MEN1 PTH
2 negative regulation of cell proliferation GO:0008285 9.56 CDC73 CDKN2C MEN1 PTHLH
3 positive regulation of cAMP biosynthetic process GO:0030819 9.48 PTH PTHLH
4 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.46 PTH PTHLH
5 beta-catenin-TCF complex assembly GO:1904837 9.43 CDC73 MEN1
6 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.4 CDKN2C MEN1
7 osteoblast development GO:0002076 9.37 MEN1 PTHLH
8 cellular calcium ion homeostasis GO:0006874 9.33 CASR GCM2 PTH
9 negative regulation of chondrocyte differentiation GO:0032331 9.32 PTH PTHLH
10 response to fibroblast growth factor GO:0071774 8.96 CASR PTH
11 cAMP metabolic process GO:0046058 8.62 PTH PTHLH

Molecular functions related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.62 PTH PTHLH

Sources for Parathyroid Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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