MCID: PRT029
MIFTS: 49

Parathyroid Adenoma malady

Summaries for Parathyroid Adenoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A parathyroid adenoma is a benign tumor of the parathyroid gland. It generally causes... more...

MalaCards: Parathyroid Adenoma, also known as adenoma of the parathyroid gland, is related to adenoma and primary hyperparathyroidism. An important gene associated with Parathyroid Adenoma is CDC73 (cell division cycle 73), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Cell cycle. The compounds estrogen and forskolin have been mentioned in the context of this disorder. Related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Aliases & Classifications for Parathyroid Adenoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT
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Aliases & Descriptions:

parathyroid adenoma 8 10 45 61
adenoma of the parathyroid gland 8


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Disease Ontology8 DOID:7608
NCIt40 C3916
SNOMED-CT57 128474007
MeSH35 D010282

Related Diseases for Parathyroid Adenoma

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Parathyroid Adenoma family:

parathyroid adenoma with cystic changes

Diseases related to Parathyroid Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 219)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma32.1LGALS3, PTH, CXADR, RET, CDKN2C, CDKN1B
2primary hyperparathyroidism31.4ALPP, PTH, PTHLH, CXADR, RET, CDC73
3parathyroid carcinoma31.3PTH, CXADR, CDC73, MEN1, CASR
4thyroid adenoma31.3LGALS3, RET, PRKAR1A, GNAS
5papillary carcinoma31.0LGALS3, RET, CDKN1B, CHGA, GNAS, CALCA
6hypercalcemia30.9ALPP, PTH, PTHLH, CXADR, CDC73, VDR
7osteitis fibrosa30.8ALPP, PTH, GNAS, CASR
8multiple endocrine neoplasia30.5RET, CDKN1B, CDC73, CHGB, CHGA, PRKAR1A
9thyroiditis30.4CALCA
10neurofibromatosis30.3RET
11multiple endocrine neoplasia type 2a30.3PTH, RET, CDC73, MEN1, CALCA
12thyroid cancer30.3LGALS3, RET, CALCA
13pheochromocytoma30.3RET, CHGB, CHGA, MEN1, GNAS, CALCA
14thyroid medullary carcinoma30.3LGALS3, RET, CHGB, CHGA, PRKAR1A, MEN1
15insulin resistance30.0GNAS
16vipoma30.0CHGA, MEN1
17rickets30.0ALPP, PTH, VDR, CASR
18hyperprolactinemia30.0PTHLH, GNAS
19familial medullary thyroid carcinoma30.0RET, CALCA
20squamous cell carcinoma30.0LGALS3, PTHLH, CCND1
21nodular goiter30.0LGALS3, RET, CALCA
22paraganglioma30.0RET, CHGB, CHGA, MEN1, CALCA
23ossifying fibroma30.0CDC73
24astrocytoma30.0LGALS3, CXADR, FGFR2, CDKN1B, CASR
25osteomalacia30.0ALPP, PTH, PTHLH, VDR, GNAS, CASR
26papillary adenoma10.7
27multinodular goiter10.4
28clear cell adenoma10.3
29breast adenoma10.3
30mixed cell type adenoma of parathyroid10.3
31oxyphilic adenoma10.3
32pregnancy adenoma10.3
33thymoma10.3
34aortopulmonary window10.3
35parathyroid adenoma, somatic10.3
36bone fracture10.2
37nontoxic goiter10.2
38acute pancreatitis10.2
39parathyroid oncocytic adenoma10.2
40water-clear cell adenoma10.2
41medullary sponge kidney10.2
42parathyroid adenoma with cystic changes10.2
43hepatocellular adenoma10.2
44endemic goiter10.0
45geotrichosis10.0
46rothmund-thomson syndrome10.0
47bone carcinoma10.0
48polycythemia vera10.0
49invasive malignant thymoma10.0
50sipple syndrome10.0

Graphical network of the top 20 diseases related to Parathyroid Adenoma:



Diseases related to parathyroid adenoma

Clinical Features for Parathyroid Adenoma

Drugs & Therapeutics for Parathyroid Adenoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Parathyroid Adenoma

Drug clinical trials:

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Search NIH Clinical Center for Parathyroid Adenoma

Search CenterWatch for Parathyroid Adenoma

Genetic Tests for Parathyroid Adenoma

Anatomical Context for Parathyroid Adenoma

Animal Models for Parathyroid Adenoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Parathyroid Adenoma:

37 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537710.3GNAS, CDKN1B
2MP:000536710.2GNAS, FGFR2, RET, LGALS3, CASR, CDC73
3MP:000537510.2CDC73, GNAS, PRKAR1A
4MP:000536910.1MEN1, CXADR, RET, CDC73, VDR, PRKAR1A
5MP:000539010.1PRKAR1A, PTHLH, LGALS3, GNAS, CCND1, FGFR2
6MP:000537910.1CCND1, CDKN2C, RET, FGFR2, CXADR, CDC73
7MP:000363110.1CHGB, GNAS, VDR, CDC73, RET, FGFR2
8MP:000538810.1FGFR2, CXADR, GNAS, PRKAR1A, LGALS3, CCND1
9MP:000538910.0FGFR2, PRKAR1A, VDR, CDC73, CDKN1B, CDKN2C
10MP:001077110.0CDKN2C, CCND1, FGFR2, CALCA, CDKN1B, CDC73
11MP:000537010.0ABCB1, CDKN1B, FGFR2, CDC73, GNAS, MEN1
12MP:000538210.0PTH, PTHLH, FGFR2, CDKN1B, VDR, GNAS
13MP:00020069.9CDKN2C, FGFR2, RET, CALCA, CDKN1B, PRKAR1A
14MP:00053769.9CXADR, FGFR2, GNAS, CDKN2C, CDC73, VDR
15MP:00053819.9CCND1, MEN1, PRKAR1A, VDR, CDC73, RET
16MP:00053869.7CCND1, PTHLH, ABCB1, CXADR, CDKN1B, CDC73
17MP:00053809.7ALPP, CXADR, FGFR2, RET, PRKAR1A, CDC73
18MP:00053979.7CDKN1B, CCND1, CASR, PRKAR1A, VDR, LGALS3
19MP:00053789.6CDKN1B, CDKN2C, RET, CDC73, VDR, CHGA
20MP:00053879.6GNAS, MEN1, PRKAR1A, VDR, CDC73, CDKN1B
21MP:00053849.6CDKN1B, CDKN2C, CDC73, CCND1, CASR, GNAS
22MP:00053859.6LGALS3, CALCA, CCND1, GNAS, MEN1, PTH
23MP:00107689.4CDKN2C, CDKN1B, CDC73, VDR, RET, FGFR2

Publications for Parathyroid Adenoma

Sources:
51PubMed
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Articles related to Parathyroid Adenoma:

(show top 50)    (show all 619)
idTitleAuthorsYear
1
Multiple organ dysfunction caused by parathyroid adenoma-induced primary hyperparathyroidism. (24326822)
2014
2
Parathyroid adenoma associated with thymoma in a female adult with primary hyperparathyroidism. (23147776)
2013
3
Parathyroid adenoma screening efficacies of different imaging tools and factors affecting the success rates. (23153996)
2012
4
Intra-operative ultrasound localisation of a parathyroid adenoma. (22041156)
2011
5
Preoperative parathyroid hormone levels are correlated with parathyroid adenoma volume and bone mineral density but not serum calcium levels. (21519321)
2011
6
Unusual parathyroid adenoma avid for both Tc-99m sestamibi and I-123 iodine due to acquisition protocol. (21637048)
2011
7
Ectopic parathyroid adenoma located inside the hypoglossal nerve. (19691113)
2010
8
A parathyroid adenoma: benign disease presenting with hyperparathyroid crisis. (21209735)
2010
9
Pivotal role of paricalcitol in the treatment of calcific uremic arteriolopathy in the presence of a parathyroid adenoma. (19481317)
2010
10
Unusual recurrence of hypercalcemia due to concurrent parathyroid adenoma and parathyroid sarcoidosis with lymph node involvement. (20061287)
2010
11
The use of gamma probe for the intraoperative localization of an ectopic parathyroid adenoma. (19714514)
2009
12
F-18 FDG-avid intrathyroidal parathyroid adenoma mimicking follicular neoplasm. (19352286)
2009
13
Revival of parathyroid adenoma: a rare cause of recurrent hyperparathyroidism. (18522581)
2008
14
Simultaneous imaging of pericardial thymoma and parathyroid adenoma by sestamibi scan. (18645372)
2008
15
SPECT/CT in localization of parathyroid adenoma or hyperplasia in patients with previous neck surgery. (18496444)
2008
16
Parathyroid chief cell adenoma associated with massive chronic parathyroiditis in a woman with hyperparathyroidism. (17652800)
2007
17
Ossifying fibroma of the mandible with primary hyperparathyroidism due to non-familial parathyroid adenoma. (17134536)
2007
18
Surveillance for early detection of aggressive parathyroid disease: carcinoma and atypical adenoma in familial isolated hyperparathyroidism associated with a germline HRPT2 mutation. (16995822)
2006
19
Preoperative localization of parathyroid adenomas with technetium-99m methoxyisobutylisonitrile imaging: relationship with P-glycoprotein expression, oxyphilic cell content, and tumoral tissue volume. (17257073)
2006
20
Parathyroid adenoma disclosed by a massive cervical hematoma. (16564403)
2006
21
Incidental parathyroid adenoma mimicking tumor recurrence in a patient with follicular thyroid carcinoma. (16424689)
2006
22
Use of fusion imaging to localize an ectopic thoracic parathyroid adenoma. (16863795)
2006
23
Ectopic parathyroid adenoma with Tc-99m MIBI washout: role of SPECT. (17053393)
2006
24
Best cases from the AFIP: primary hyperparathyroidism due to parathyroid adenoma. (15888628)
2005
25
Unusual presentation of a giant parathyroid adenoma: report of a case. (15772795)
2005
26
Mutational analysis of Smad3, a candidate tumor suppressor implicated in TGF-beta and menin pathways, in parathyroid adenomas and enteropancreatic endocrine tumors. (12161532)
2002
27
Retrotracheal parathyroid adenoma. (11881169)
2002
28
Dose-response relationship for parathyroid adenoma after exposure to ionizing radiation in infancy. (12236809)
2002
29
Visual vignette. Hyperparathyroidism due to a parathyroid adenoma. (11441818)
2000
30
Intrathymic parathyroid adenoma: planar and SPECT Tc-99m sestamibi scintigraphy. (10634536)
2000
31
Is unilateral neck exploration for parathyroid adenoma appropriate? (10997226)
2000
32
A newly recognized germline mutation of MEN1 gene identified in a patient with parathyroid adenoma and carcinoma. (10963041)
2000
33
Effect of vitamin D nutrition on parathyroid adenoma weight: pathogenetic and clinical implications. (10720039)
2000
34
Bilateral hemothorax revealing mediastinal parathyroid adenoma. (10202326)
1999
35
A retroesophageal parathyroid adenoma detected with Tc-99m sestamibi and MRI. (10595493)
1999
36
Expression of cyclin D1 in parathyroid carcinomas, adenomas, and hyperplasias: a paraffin immunohistochemical study. (10229506)
1999
37
A peculiar Factor VIII-related antigen staining of an oxyphilic cell nodule within an intrathyroidal parathyroid adenoma. (10338086)
1999
38
Technetium-99m pertechnetate uptake in ectopic parathyroid adenoma. (10355956)
1999
39
You're the flight surgeon. Parathyroid adenoma with primary hyperparathyroidism, recurrent renal calculi, and brown tumor. (9773908)
1998
40
Oxyphilic parathyroid adenoma and lithium therapy. (9759787)
1998
41
Remission of primary hyperparathyroidism due to spontaneous infarction of a parathyroid adenoma. Case report and review of the literature. (9854603)
1998
42
SPECT and subtraction imaging of an ectopic parathyroid adenoma. (9227867)
1997
43
Kinetics of Tc-99m sestamibi and Tc-99m tetrofosmin in a case of parathyroid adenoma. (8879870)
1996
44
Multiple lipomas, angiolipomas, and parathyroid adenomas in a patient with Birt-Hogg-Dube syndrome. (8734663)
1996
45
The role of pre-operative thallium-technetium subtraction scintigraphy in the surgical management of patients with solitary parathyroid adenoma. (8641112)
1996
46
Preoperative localization of a parathyroid adenoma with Tc-99m sestamibi imaging in a patient with concomitant nontoxic multinodular goiter. (7895432)
1995
47
Tc-99m sestamibi uptake by parathyroid carcinoma. False-positive localization of parathyroid adenoma. (7586884)
1995
48
Peptide-containing nerve fibres in normal human parathyroid glands and in human parathyroid adenomas. (7581983)
1995
49
Tc-99m sestamibi imaging of a pancreatic VIPoma and parathyroid adenoma in a patient with multiple type I endocrine neoplasia. (7914844)
1994
50
Immunohistochemical localization of parathyroid hormone-related protein in parathyroid adenoma and hyperplasia. (2196348)
1990

Genetic Variations for Parathyroid Adenoma

Expression for genes affiliated with Parathyroid Adenoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Parathyroid Adenoma

Search GEO for disease gene expression data for Parathyroid Adenoma.

Pathways for genes affiliated with Parathyroid Adenoma

Sources:
12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 4Cell Signaling Technology
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Pathways related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.3VDR, PTH
2
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10.3CDKN2C, CDKN1B, MEN1
3
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10.3CDKN1B, CDKN2C, CCND1
4
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10.2CDC73, CDKN1B, CDKN2C, CCND1
5
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10.2FGFR2, CDKN2C, CDKN1B, CCND1
6
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10.2GNAS, PRKAR1A, VDR, CDKN1B
7
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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10.0CCND1, PTH, PTHLH, VDR, PRKAR1A, GNAS
8
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9.8PTHLH, FGFR2, CDKN1B, PRKAR1A, MEN1, GNAS

Compounds for genes affiliated with Parathyroid Adenoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Parathyroid Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 136)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8VDR
2forskolin45 50 1112.7PTH, CALCA, PRKAR1A
3glutamate4510.7CASR, PRKAR1A, GNAS
422-oxacalcitriol4510.6ALPP, PTHLH, VDR, CASR
5calcium carbonate4510.5CALCA, ALPP, PTH, PTHLH
6pamidronate45 50 1112.5ALPP, PTH, CASR, CALCA, PTHLH
7cinacalcet45 29 1112.5CALCA, CASR, PRKAR1A, CXADR
8alendronate45 50 1112.5VDR, CALCA, PTHLH, PTH, ALPP
925-hydroxyvitamin d4510.5CASR, CALCA, VDR, ALPP, PTHLH, PTH
10phosphorus4510.5CALCA, CASR, VDR, PTHLH, PTH, ALPP
11deoxypyridinoline4510.4PTH, VDR, CALCA
12eb 108945 6011.4CCND1, CDKN1B, PTHLH, VDR
13bromodeoxyuridine4510.4FGFR2, PTHLH, CDKN1B, PTH, CCND1, CHGA
14neomycin4510.4CASR, PRKAR1A, ALPP, PTHLH, CXADR
15acth4510.4CASR, GNAS, CHGA, CHGB, LGALS3
16l-amino acid4510.4PRKAR1A, CHGA, CXADR, CASR
17etidronic acid45 50 1112.3ALPP, VDR, CALCA
181,25 dihydroxy vitamin d34510.3CALCA, CASR, ALPP, VDR, CDKN1B, CXADR
19dexamethasone45 50 29 1113.3ALPP, CHGB, ABCB1, VDR, CDKN1B, CXADR
20calcitriol45 60 11 2413.3PTH, ALPP, CASR, VDR, CDKN1B, CALCA
21guanine45 11 2412.3CCND1, GNAS, CHGA, VDR, CALCA, FGFR2
22agar4510.3FGFR2, RET, CDKN1B, PTHLH, CCND1, LGALS3
23ribonucleic acid4510.3PTHLH, RET, FGFR2, CHGA, GNAS, CXADR
24tamoxifen45 50 29 1113.2CDKN1B, FGFR2, ABCB1, CHGA, PTH, ALPP
25paraffin4510.2PTHLH, CHGA, CDKN1B, LGALS3, ALPP, RET
26cyclic amp45 2411.2CDKN1B, PTHLH, GNAS, CASR, RET, CHGA
27steroid4510.2GNAS, PRKAR1A, VDR, FGFR2, CXADR, CCND1
28genistein45 29 60 2 11 2415.2ABCB1, CCND1, CDKN1B, RET, FGFR2, VDR
29progesterone45 60 29 11 2414.2GNAS, PTHLH, ABCB1, FGFR2, CDKN1B, CHGA
30cisplatin45 50 60 1113.2FGFR2, CXADR, ABCB1, PTHLH, LGALS3, CHGA
31thymidine45 2411.2CXADR, ALPP, PTH, PTHLH, MEN1, FGFR2
3224,25-dihydroxyvitamin d34510.1ALPP, VDR, CALCA
33creatinine4510.1PTHLH, ALPP, PTH, CASR, CHGA, VDR
34threonine4510.1CDKN1B, CDKN2C, RET, FGFR2, PTHLH, LGALS3
35nitric oxide45 11 2412.1CXADR, CASR, CHGA, CDKN1B, CALCA, FGFR2
36adenylate4510.1GNAS, CASR, CALCA, CCND1, PRKAR1A, CHGA
37paclitaxel45 50 1112.1CDKN1B, CCND1, ABCB1, CHGA, FGFR2
38serine4510.1CDKN2C, RET, CXADR, CCND1, ALPP, CDKN1B
39vegf4510.1LGALS3, PTH, PTHLH, FGFR2, RET, CDKN1B
40alanine4510.1PTHLH, CASR, GNAS, VDR, ALPP, CDKN1B
41testosterone45 60 11 2413.1FGFR2, CCND1, VDR, CALCA, CHGA, ALPP
42vitamin d4510.0VDR, ALPP, PTHLH, PTH, LGALS3, CXADR
43retinoic acid45 2411.0LGALS3, CXADR, ALPP, PTHLH, CHGA, CCND1
44cycloheximide4510.0ALPP, PTH
45oligonucleotide4510.0CDKN1B, CHGB, RET, GNAS, CCND1, FGFR2
46norepinephrine45 11 2412.0CALCA, PTHLH, CHGB, CHGA, ALPP, GNAS
47cysteine4510.0CXADR, ALPP, CASR, GNAS, LGALS3, FGFR2
48tyrosine459.9CHGA, PTHLH, PTH, LGALS3, FGFR2, RET
49arginine459.9PRKAR1A, CASR, GNAS, CHGA, CDKN1B, ALPP
50calcium45 50 11 2412.8GNAS, CHGA, RET, PRKAR1A, ALPP, VDR

GO Terms for genes affiliated with Parathyroid Adenoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.9PTHLH, CXADR, FGFR2, CHGB, CHGA, GNAS

Biological processes related to Parathyroid Adenoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1cAMP metabolic processGO:04605810.4PTHLH, PTH
2adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.3CALCA, PTHLH, PTH
3positive regulation of cAMP biosynthetic processGO:03081910.3CALCA, GNAS, PTHLH, PTH
4skeletal system developmentGO:00150110.3LGALS3, PTH, PTHLH, VDR
5negative regulation of cell proliferationGO:00828510.2PTHLH, FGFR2, CDKN2C, CDKN1B, CDC73, VDR
6negative regulation of transcription from RNA polymerase II promoterGO:00012210.1PTH, FGFR2, CDC73, VDR, MEN1
7cell-cell signalingGO:00726710.1PTH, PTHLH, FGFR2, CALCA
8cellular calcium ion homeostasisGO:00687410.0CASR, VDR, PTH

Molecular functions related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.3CDKN2C, CDKN1B
2hormone activityGO:00517910.1CALCA, CHGB, PTHLH, PTH
3peptide hormone receptor bindingGO:05142810.1PTH, PTHLH
4protein bindingGO:0055159.3LGALS3, CCND1, CALCA, CASR, GNAS, MEN1

Products for genes affiliated with Parathyroid Adenoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Parathyroid Adenoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet