MCID: PRT029
MIFTS: 50

Parathyroid Adenoma

Categories: Endocrine diseases, Cancer diseases

Aliases & Classifications for Parathyroid Adenoma

MalaCards integrated aliases for Parathyroid Adenoma:

Name: Parathyroid Adenoma 12 28 51 14 69
Adenoma of the Parathyroid Gland 12
Adenoma of Parathyroid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7608
MeSH 41 D010282
NCIt 46 C3916
SNOMED-CT 64 128474007
UMLS 69 C0262587

Summaries for Parathyroid Adenoma

MalaCards based summary : Parathyroid Adenoma, also known as adenoma of the parathyroid gland, is related to hyperparathyroidism 1 and hyperparathyroidism 2 with jaw tumors. An important gene associated with Parathyroid Adenoma is CDC73 (Cell Division Cycle 73), and among its related pathways/superpathways are Mesodermal Commitment Pathway and G alpha (s) signalling events. The drugs Denosumab and Vitamin D have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related phenotypes are endocrine/exocrine gland and cardiovascular system

Wikipedia : 72 A parathyroid adenoma is a benign tumor of the parathyroid gland. It generally causes... more...

Related Diseases for Parathyroid Adenoma

Diseases related to Parathyroid Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
# Related Disease Score Top Affiliating Genes
1 hyperparathyroidism 1 33.4 CDC73 MEN1
2 hyperparathyroidism 2 with jaw tumors 32.4 CASR CCND1 CDC73 MEN1 RET
3 chief cell adenoma 32.1 GCM2 PTH
4 parathyroid carcinoma 31.7 CALCA CASR CCND1 CDC73 MEN1 PTH
5 osteitis fibrosa 31.7 BGLAP CALCA CASR PTH
6 multiple endocrine neoplasia, type iia 31.6 CALCA CDC73 MEN1 PTH RET
7 adenoma 31.5 CCND1 CDC73 CTNNB1 MEN1 RET
8 hypercalcemia, infantile, 1 30.3 CALCA CASR PTH PTHLH
9 invasive malignant thymoma 30.1 PTH PTHLH
10 familial hypocalciuric hypercalcemia 30.0 CASR CDC73 PTH
11 thyroid cancer, nonmedullary, 1 29.9 CALCA CCND1 CTNNB1 MEN1 RET
12 multiple endocrine neoplasia 29.7 CALCA CHGA MEN1 RET
13 vipoma 29.6 CALCA CHGA
14 thyroid cancer 29.6 CALCA CCND1 CTNNB1 RET
15 pheochromocytoma 29.5 CALCA CHGA MEN1 RET
16 thyroid carcinoma, familial medullary 29.4 CALCA CHGA MEN1 RET
17 paraganglioma 29.4 CALCA CHGA RET
18 secondary hyperparathyroidism of renal origin 29.4 BGLAP CALCA CASR PTH
19 thyroid cancer, nonmedullary, 2 29.2 CALCA CHGA MEN1 RET
20 osteomalacia 29.1 BGLAP CALCA CASR PTHLH
21 multiple endocrine neoplasia, type i 28.7 CASR CDC73 CDKN2C CHGA MEN1 PTH
22 hyperparathyroidism 28.4 BGLAP CALCA CASR CDC73 CHGA GCM2
23 primary hyperparathyroidism 28.0 BGLAP CALCA CASR CCND1 CDC73 CHGA
24 mixed cell type adenoma of parathyroid 12.1
25 birt-hogg-dube syndrome 11.3
26 mediastinitis 10.6
27 thyroiditis 10.5
28 parathyroid transitional clear cell adenoma 10.5 MEN1 PTH
29 hemimegalencephaly 10.5 CCND1 CTNNB1
30 multiple endocrine neoplasia type 1 and type 2 10.5 MEN1 RET
31 hypocalciuric hypercalcemia, familial, type iii 10.4 CASR PTHLH
32 calciphylaxis 10.4 CASR PTH
33 multiple endocrine neoplasia, type iv 10.4 CDKN2C MEN1
34 juxtacortical chondroma 10.4 CTNNB1 PTHLH
35 hypocalciuric hypercalcemia, familial, type ii 10.4 CASR PTH
36 oncogenic osteomalacia 10.3 PTH PTHLH
37 goblet cell carcinoid 10.3 CHGA CTNNB1
38 endocrine organ benign neoplasm 10.3 CDC73 MEN1 PTH
39 periosteal chondrosarcoma 10.3 CTNNB1 PTHLH
40 pancreatic somatostatinoma 10.3 CALCA MEN1
41 pancreatic islet cell tumors 10.3 CALCA MEN1
42 cervicitis 10.3
43 axial osteomalacia 10.3 BGLAP PTH
44 liver sarcoma 10.3 CHGA PTHLH
45 hypoparathyroidism, familial isolated 10.3 GCM2 PTH
46 pulmonary sclerosing hemangioma 10.3 CHGA CTNNB1
47 fibrogenesis imperfecta ossium 10.3 CALCA PTH
48 hyperparathyroidism 3 10.2 CDC73 GCM2 MEN1
49 cell type cancer 10.2 CCND1 CHGA CTNNB1
50 pancreatic gastrinoma 10.2 CHGA MEN1 PTHLH

Graphical network of the top 20 diseases related to Parathyroid Adenoma:



Diseases related to Parathyroid Adenoma

Symptoms & Phenotypes for Parathyroid Adenoma

MGI Mouse Phenotypes related to Parathyroid Adenoma:

43 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.27 CHGA MEN1 CTNNB1 PTH PTHLH GCM2
2 cardiovascular system MP:0005385 10.25 MEN1 CHGA CTNNB1 PTH ABCB1 CDC73
3 cellular MP:0005384 10.24 GCM2 MEN1 CTNNB1 PTH CDKN2C CCND1
4 growth/size/body region MP:0005378 10.22 CHGA MEN1 CTNNB1 PTH CDKN2C ABCB1
5 homeostasis/metabolism MP:0005376 10.21 CHGA MEN1 CTNNB1 PTH GCM2 ABCB1
6 mortality/aging MP:0010768 10.15 CHGA MEN1 CTNNB1 PTH GCM2 ABCB1
7 digestive/alimentary MP:0005381 10.11 MEN1 CTNNB1 ABCB1 CDC73 CASR CCND1
8 hematopoietic system MP:0005397 10.11 CTNNB1 PTH CDKN2C CCND1 ABCB1 CDC73
9 immune system MP:0005387 10.1 MEN1 CTNNB1 PTH CDKN2C CCND1 ABCB1
10 craniofacial MP:0005382 10.07 GCM2 MEN1 CTNNB1 PTH CCND1 CDC73
11 nervous system MP:0003631 9.91 CDKN2C GCM2 MEN1 CTNNB1 CCND1 ABCB1
12 neoplasm MP:0002006 9.8 MEN1 CTNNB1 CDKN2C CCND1 CDC73 RET
13 renal/urinary system MP:0005367 9.76 CHGA CTNNB1 GCM2 CDC73 CASR CDKN2C
14 reproductive system MP:0005389 9.61 CHGA MEN1 CTNNB1 ABCB1 CDC73 CCND1
15 respiratory system MP:0005388 9.1 CDKN2C CTNNB1 CCND1 CDC73 RET PTHLH

Drugs & Therapeutics for Parathyroid Adenoma

Drugs for Parathyroid Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 3 615258-40-7
2
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
3 Bone Density Conservation Agents Phase 3
4 Calcium, Dietary Phase 3
5 Vitamins Phase 3
6 Hormones Phase 3
7 Hormone Antagonists Phase 3
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
9 Calcimimetic Agents Phase 3
10 Cinacalcet Hydrochloride Phase 3
11
Choline Approved, Nutraceutical Phase 2 62-49-7 305
12 Antimetabolites Phase 2
13 Gastrointestinal Agents Phase 2
14 Hypolipidemic Agents Phase 2
15 Lipid Regulating Agents Phase 2
16 Nootropic Agents Phase 2
17 Micronutrients
18 Trace Elements
19 Anesthetics
20 Fluorides

Interventional clinical trials:

(show all 18)

# Name Status NCT ID Phase Drugs
1 Treatment of Primary Hyperparathyroidism With Denosumab and Cinacalcet. Enrolling by invitation NCT03027557 Phase 3 Cinacalcet 30 mg Tablet;Denosumab Inj 60 mg/ml
2 Interest of the F18-choline as a Second Line of the Tracer for Detection of Parathyroid Adenomas Completed NCT02432599 Phase 2
3 Input of C11-Choline PET/CT in Localization of Parathyroid Adenoma Unknown status NCT01221896
4 Evaluation of a New CZT System Unknown status NCT01084356
5 Differentially Expressed Proteins in Sporadic Parathyroid Tumors Unknown status NCT01647503
6 Regulation of Vitamin D Receptor (VDR),Calcium Sensing Receptor (CaSR), Cyclin D1,Ki67 and Proliferating Cell Nuclear Antigen (PCNA) in Primary Hyperparathyroidism Unknown status NCT01228786
7 Observation of Histological Changes in Parathyroid Adenomas Following High Intensity Focused Ultrasound (HIFU) Treatment Procedure Completed NCT01060982
8 Using X-Ray Dye to Locate Hidden Parathyroid Tumors Completed NCT00001394
9 Minimally Invasive Radioguided Parathyroidectomy Completed NCT01530919
10 Open Versus Video-Assisted Minimal-Invasive Parathyroid Surgery Completed NCT00877981
11 Anti-3-[18F]FACBC Imaging of Parathyroid Adenomas Recruiting NCT01574287 FACBC
12 Omission of Intact Parathyroid Hormone Testing During Surgery in Treating Patients With Primary Hyperparathyroidism Recruiting NCT03011736
13 Molecular and IHC Profiling of PTH Tumors to Evaluate Targeted Agents Recruiting NCT03039439
14 Localization of Parathyroid Adenoma by Fluorocholine PET/MRI (Positron Emission Tomography -MRI) Not yet recruiting NCT02843542
15 FCH PET/MRI Parathyroid Localization Not yet recruiting NCT03324893
16 High Intensity Focused Ultrasound (HIFU) for Parathyroid Adenoma Terminated NCT01291498
17 Evaluation of MRI and SPECT Fusion Software to Localize Parathyroid Adenomas Terminated NCT00639405
18 Multicenter Registry Comparing Preoperative Imaging for Primary Hyperparathyroidism Withdrawn NCT02381925

Search NIH Clinical Center for Parathyroid Adenoma

Genetic Tests for Parathyroid Adenoma

Genetic tests related to Parathyroid Adenoma:

# Genetic test Affiliating Genes
1 Parathyroid Adenoma 28

Anatomical Context for Parathyroid Adenoma

MalaCards organs/tissues related to Parathyroid Adenoma:

38
Thyroid, Bone, Testes, Breast, Lymph Node, Lung, Thymus

Publications for Parathyroid Adenoma

Articles related to Parathyroid Adenoma:

(show top 50) (show all 736)
# Title Authors Year
1
A Migratory Mishap: Giant Mediastinal Parathyroid Adenoma. ( 29360437 )
2018
2
Role of fine needle aspiration cytology in diagnosis of brown tumor secondary to parathyroid adenoma. ( 29403220 )
2018
3
Ectopic Undescended Parathyroid Adenoma-SPECT/CT Avoids False-Negative Interpretation on 99mTc-MIBI Dual-Phase Scintigraphy. ( 29293139 )
2018
4
Giant parathyroid adenoma: differential aspects compared to parathyroid carcinoma. ( 28491324 )
2017
5
Percentage arterial enhancement: An objective index for accurate identification of parathyroid adenoma/hyperplasia inA primary hyperparathyroidism. ( 28656592 )
2017
6
Comparative Diagnostic Performance of Ultrasonography and 99mTc-Sestamibi Scintigraphy for Parathyroid Adenoma in Primary Hyperparathyroidism; Systematic Review and Meta- Analysis ( 29281866 )
2017
7
Excision of an Elusive Tiny Ectopic Parathyroid Adenoma. ( 29430234 )
2017
8
Concomitant occurrence of primary hyperparathyroidism (PHPT) due to mediastinal parathyroid adenoma and sublingual thyroid gland: the role of parathyroid technetium-99m-MIBI scintigraphy. ( 29152292 )
2017
9
Sensitive Detection of a Small Parathyroid Adenoma Using Fluorocholine PET/CT: A Case Report. ( 28559945 )
2017
10
Non-traumatic rupture of the superior thyroid artery with concomitant parathyroid adenoma and multinodular goiter. ( 28811931 )
2017
11
Parathyroid adenoma with concurrent toxic thyroid adenoma: a rare combination. ( 28876558 )
2017
12
Decrease in size and activity of parathyroid adenoma after ultrasound guided biopsy. ( 28914043 )
2017
13
EZH2 copy number and mutational analyses in sporadic parathyroid adenomas. ( 27738890 )
2017
14
Management of mediastinal parathyroid adenoma via minimally invasive thoracoscopic surgery: Case report. ( 28988020 )
2017
15
Synchronous parathyroid adenoma and papillary thyroid carcinoma: 99mTc-MIBI Scan Findings. ( 29303141 )
2017
16
Molecular profiles of oxyphilic and chief cell parathyroid adenoma. ( 28986304 )
2017
17
Ambulatory surgery under local anesthesia for parathyroid adenoma: Feasibility and outcome. ( 29275894 )
2017
18
Giant mediastinal parathyroid adenoma presenting as bilateral brown tumour of mandible: a rare presentation of primary hyperparathyroidism. ( 29066636 )
2017
19
Parathyroid carcinoma in a patient with three prior parathyroid adenomas. ( 28636744 )
2017
20
A Case of Hyperparathyroidism due to a Large Intrathyroid Parathyroid Adenoma with Recurrent Episodes of Acute Pancreatitis. ( 28815093 )
2017
21
An unusual cause of hypercalcemic crisis: Water-clear cell double parathyroid adenoma. ( 29260127 )
2017
22
Ureteropelvic Junction Obstruction and Parathyroid Adenoma: Coincidence or Link? ( 29181209 )
2017
23
Protean Presentations of Parathyroid Adenoma in Childhood. ( 28082776 )
2017
24
Comparative Effectiveness of Ultrasonography, 99mTc-Sestamibi, and 18F-Fluorocholine PET/CT in Detecting Parathyroid Adenomas in Patients With Primary Hyperparathyroidism. ( 28902729 )
2017
25
An occult ectopic parathyroid adenoma in a pediatric patient: a case report and management algorithm. ( 28809753 )
2017
26
Atypical Parathyroid Adenoma with Multiple Brown Tumors as Initial Presentation: A Rare Entity. ( 28533644 )
2017
27
Descended right superior parathyroid adenoma mimicking as inferior adenoma in primary hyperparathyroidism. ( 28775111 )
2017
28
Intrathymic Parathyroid Adenoma. ( 28502343 )
2017
29
Clinical Images: Four-Dimensional Computed Tomography-Future of Preoperative Parathyroid Adenoma Imaging. ( 29026351 )
2017
30
A Herald of Plasma Cell Myeloma: A Report of Malignant Plasma Cells Identified in Parathyroid Adenoma and a Review of Non-parathyroid Malignancies in Parathyroid Glands. ( 29030756 )
2017
31
Typifying the Atypical Parathyroid Adenoma. ( 28680226 )
2017
32
Loss of p27 expression is associated with MEN1 gene mutations in sporadic parathyroid adenomas. ( 27038812 )
2017
33
Surgery for Ectopic Parathyroid Adenoma in Lower Part of Superior Mediastinum through a Transcervical Incision. ( 28524839 )
2017
34
Percutaneous Transsternal Cryoablation of Ectopic Parathyroid Adenoma in the Anterior Mediastinum. ( 29264453 )
2017
35
Diffuse hematoma caused by spontaneous rupture of a parathyroid adenoma: a case report. ( 28728949 )
2017
36
Intravagal Parathyroid Adenoma With Direct Surgery. ( 28756868 )
2017
37
A case of severe acute necrotizing pancreatitis in a 38-year-old woman postpartum due to a parathyroid adenoma. ( 28868227 )
2017
38
Ectopic Parathyroid Adenoma Presenting as a Mediastinal Mass. ( 28658791 )
2017
39
Primary hyperparathyroidism caused by mediastinal ectopic parathyroid adenoma. ( 28775222 )
2017
40
Unilateral Exploration for Parathyroid Adenoma. ( 28546708 )
2017
41
Ectopic parathyroid adenoma in the pyriform sinus. ( 28741786 )
2017
42
Gestational Primary Hyperparathyroidism Due to Ectopic Parathyroid Adenoma: Case Report and Literature Review. ( 29264569 )
2017
43
(11)C-Methionine positron emission tomography-computed tomography in localization of methoxyisobutyl isonitrile negative ectopic parathyroid adenoma. ( 26917896 )
2016
44
Hybrid-fusion SPECT/CT systems in parathyroid adenoma: Technological improvements and added clinical diagnostic value. ( 27554661 )
2016
45
Detection of Synchronous Parathyroid Adenoma and Breast Cancer with (18)F-Fluorocholine PET-CT. ( 27275374 )
2016
46
Shear wave elastography and parathyroid adenoma: A new tool for diagnosing parathyroid adenomas. ( 27501893 )
2016
47
Parathyroid adenoma: a comprehensive biochemical and histological correlative study. ( 27696726 )
2016
48
Outcomes of minimally invasive parathyroidectomy in pediatric patients with primary hyperparathyroidism owing to parathyroid adenoma: A single institution experience. ( 26898682 )
2016
49
Multiple Brown Tumors Caused by a Parathyroid Adenoma Mimicking Metastatic Bone Disease from Giant Cell Tumor. ( 26912981 )
2016
50
Allocation of parathyroid adenoma and suspicious thyroid nodule by real-time (99m)Tc-MIBI SPECT/US fusion imaging. ( 27259507 )
2016

Variations for Parathyroid Adenoma

ClinVar genetic disease variations for Parathyroid Adenoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CDC73 CDC73, 4-BP DEL, 685AGAG deletion Pathogenic
2 MEN1 NM_000244.3(MEN1): c.669+1delG deletion Pathogenic rs1057518903 GRCh37 Chromosome 11, 64575362: 64575362

Copy number variations for Parathyroid Adenoma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 25580 1 191357783 191487679 Loss HRPT2 Parathyroid adenoma
2 33979 1 51206195 51212897 Loss CDKN2C Parathyroid adenoma
3 33993 1 51300000 56200000 Loss RNF11 Parathyroid adenoma
4 48482 11 1 48800000 Losse MEN1 Parathyroid adenoma
5 192952 5 121500000 127300000 Gaine LMNB1 Parathyroid adenoma
6 192953 5 121500000 127300000 Gaine PIK3R1 Parathyroid adenoma

Expression for Parathyroid Adenoma

Search GEO for disease gene expression data for Parathyroid Adenoma.

Pathways for Parathyroid Adenoma

GO Terms for Parathyroid Adenoma

Biological processes related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.85 CDC73 CDKN2C CTNNB1 MEN1 PTHLH
2 response to organic cyclic compound GO:0014070 9.75 BGLAP CASR CCND1
3 response to ethanol GO:0045471 9.74 BGLAP CCND1 PTH
4 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.69 CALCA PTH PTHLH
5 skeletal system development GO:0001501 9.67 BGLAP CTNNB1 PTH PTHLH
6 vasculature development GO:0001944 9.63 CALCA CTNNB1
7 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.62 CDKN2C MEN1
8 vasodilation GO:0042311 9.62 CALCA CASR
9 bone resorption GO:0045453 9.61 CTNNB1 PTH
10 negative regulation of osteoclast differentiation GO:0045671 9.61 CALCA CTNNB1
11 positive regulation of cAMP biosynthetic process GO:0030819 9.61 CALCA PTH PTHLH
12 response to vitamin D GO:0033280 9.59 BGLAP PTH
13 response to pain GO:0048265 9.58 CALCA RET
14 beta-catenin-TCF complex assembly GO:1904837 9.58 CDC73 CTNNB1 MEN1
15 regulation of osteoclast differentiation GO:0045670 9.56 BGLAP CTNNB1
16 cellular calcium ion homeostasis GO:0006874 9.56 CALCA CASR GCM2 PTH
17 positive regulation of ossification GO:0045778 9.55 CALCA PTH
18 positive regulation of cAMP metabolic process GO:0030816 9.54 CALCA CHGA
19 cellular response to vitamin D GO:0071305 9.52 BGLAP CASR
20 response to fibroblast growth factor GO:0071774 9.49 CASR PTH
21 endodermal cell fate commitment GO:0001711 9.48 CDC73 CTNNB1
22 negative regulation of chondrocyte differentiation GO:0032331 9.33 CTNNB1 PTH PTHLH
23 cAMP metabolic process GO:0046058 9.32 PTH PTHLH
24 osteoblast development GO:0002076 9.13 BGLAP MEN1 PTHLH
25 response to drug GO:0042493 9.1 ABCB1 BGLAP CCND1 CTNNB1 PTH RET
26 negative regulation of transcription by RNA polymerase II GO:0000122 10 CCND1 CDC73 CTNNB1 MEN1 PTH

Molecular functions related to Parathyroid Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 CALCA PTH PTHLH
2 peptide hormone receptor binding GO:0051428 8.62 PTH PTHLH

Sources for Parathyroid Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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