MCID: PRT029
MIFTS: 56

Parathyroid Adenoma malady

Endocrine diseases category

Summaries for Parathyroid Adenoma

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 A parathyroid adenoma is a benign tumor of the parathyroid gland. It generally causes... more...

MalaCards: Parathyroid Adenoma, also known as adenoma of the parathyroid gland, is related to adenoma and hyperparathyroidism. An important gene associated with Parathyroid Adenoma is CDC73 (cell division cycle 73), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Cell cycle. The compounds estrogen and forskolin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and pituitary, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Aliases & Classifications for Parathyroid Adenoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

parathyroid adenoma 8 10 44 60
adenoma of the parathyroid gland 8


External Ids:

Disease Ontology8 DOID:7608
NCIt39 C3916
SNOMED-CT56 128474007
MeSH34 D010282

Related Diseases for Parathyroid Adenoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Parathyroid Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma32.0LGALS3, PTH, CXADR, RET, CDKN2C, CDKN1B
2hyperparathyroidism31.4ALPP, PTH, PTHLH, CXADR, RET, CDKN1B
3primary hyperparathyroidism31.4ALPP, PTH, PTHLH, CXADR, RET, CDC73
4parathyroid carcinoma31.2PTH, CXADR, CDC73, MEN1, CASR
5thyroiditis31.2CALCA
6papillary carcinoma30.9LGALS3, RET, CDKN1B, CHGA, GNAS, CALCA
7papillary thyroid carcinoma30.9LGALS3, RET, MEN1, CALCA, CCND1
8hypercalcemia30.9ALPP, PTH, PTHLH, CXADR, CDC73, VDR
9osteitis fibrosa30.7ALPP, PTH, GNAS, CASR
10goiter30.6LGALS3, PTH, RET, GNAS, CALCA
11follicular adenoma30.5LGALS3, RET, GNAS, CALCA
12sarcoidosis30.4ALPP
13pancreatitis30.3ALPP, CASR
14meningioma30.2CXADR, FGFR2, CDKN2C, MEN1
15neurofibromatosis30.2RET
16multiple endocrine neoplasia type 2a30.2PTH, RET, CDC73, MEN1, CALCA
17follicular thyroid carcinoma30.2LGALS3, RET, CALCA
18myeloma30.2ALPP, PTHLH, ABCB1, CDKN2C, CCND1
19pheochromocytoma30.2RET, CHGB, CHGA, MEN1, GNAS, CALCA
20thyroid cancer30.2LGALS3, RET, CDKN1B, GNAS, CASR, CALCA
21thyroid medullary carcinoma30.2LGALS3, RET, CHGB, CHGA, PRKAR1A, MEN1
22breast cancer30.2LGALS3, PTHLH, ABCB1, FGFR2, CDKN1B, CHGB
23hepatocellular carcinoma30.2ALPP, ABCB1, CXADR, FGFR2, CDKN2C, CDKN1B
24multiple myeloma30.2ABCB1, CCND1
25obesity30.0GNAS
26hypertension30.0PTH, CALCA
27vipoma30.0CHGA, MEN1
28hyperthyroidism30.0ALPP, PTH, GNAS
29hypogonadism30.0CALCA
30cholangiocarcinoma30.0ALPP, LGALS3, CDKN1B
31rickets30.0ALPP, PTH, VDR, CASR
32familial medullary thyroid carcinoma30.0RET, CALCA
33hyperprolactinemia30.0PTHLH, GNAS
34hemangioma30.0RET, MEN1
35papilloma30.0CDKN1B
36squamous cell carcinoma30.0LGALS3, PTHLH, CCND1
37nodular goiter30.0LGALS3, RET, CALCA
38paraganglioma30.0RET, CHGB, CHGA, MEN1, CALCA
39ossifying fibroma30.0CDC73
40astrocytoma30.0LGALS3, CXADR, FGFR2, CDKN1B, CASR
41diabetes mellitus30.0ALPP, PTH, VDR, CASR, CALCA
42chondrosarcoma30.0PTHLH, FGFR2
43osteomalacia30.0ALPP, PTH, PTHLH, VDR, GNAS, CASR
44lung cancer30.0PTHLH, ABCB1, CXADR, CHGA
45pituitary adenoma30.0LGALS3, FGFR2, RET, CDKN1B, CHGB, CHGA
46mediastinitis10.9
47papillary adenoma10.6
48cervicitis10.6
49oxyphilic adenoma10.4
50multinodular goiter10.4

Graphical network of the top 20 diseases related to Parathyroid Adenoma:



Diseases related to parathyroid adenoma

Clinical Features for Parathyroid Adenoma

About this section

Drugs & Therapeutics for Parathyroid Adenoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Parathyroid Adenoma

Drug clinical trials:

Search ClinicalTrials for Parathyroid Adenoma

Search NIH Clinical Center for Parathyroid Adenoma

Search CenterWatch for Parathyroid Adenoma

Genetic Tests for Parathyroid Adenoma

About this section

Anatomical Context for Parathyroid Adenoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Parathyroid Adenoma:

32
Thyroid, Bone, Pituitary, Breast, Lymph node, Lung, Kidney, Thymus, Testes, Liver, Salivary gland

Animal Models for Parathyroid Adenoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Parathyroid Adenoma:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537710.3CDKN1B, GNAS
2MP:000536710.2CASR, GNAS, CHGA, CDC73, RET, FGFR2
3MP:000537510.2GNAS, PRKAR1A, CDC73
4MP:000536910.1CASR, MEN1, PRKAR1A, VDR, CDC73, RET
5MP:000539010.1CCND1, GNAS, PRKAR1A, FGFR2, PTHLH, LGALS3
6MP:000537910.1CXADR, FGFR2, RET, CDKN2C, CDKN1B, CDC73
7MP:000363110.1GNAS, CHGB, VDR, CDC73, RET, FGFR2
8MP:000538810.1CCND1, GNAS, PRKAR1A, CDKN1B, CDKN2C, FGFR2
9MP:000538910.0CCND1, MEN1, PRKAR1A, VDR, CDC73, CDKN1B
10MP:001077110.0CCND1, CALCA, CASR, GNAS, VDR, CDC73
11MP:000537010.0ABCB1, FGFR2, CDKN1B, CDC73, MEN1, GNAS
12MP:000538210.0CCND1, GNAS, MEN1, PRKAR1A, VDR, CDKN1B
13MP:00020069.9CCND1, CALCA, MEN1, PRKAR1A, CDKN1B, CDKN2C
14MP:00053769.9PRKAR1A, MEN1, GNAS, CASR, CALCA, CHGB
15MP:00053819.9VDR, PRKAR1A, MEN1, CASR, CCND1, CDC73
16MP:00053869.7VDR, GNAS, CASR, CALCA, CCND1, CDC73
17MP:00053809.7PRKAR1A, CDC73, RET, FGFR2, CXADR, ALPP
18MP:00053979.7CDC73, VDR, PRKAR1A, GNAS, CASR, CCND1
19MP:00053789.6CHGA, PRKAR1A, MEN1, GNAS, CASR, CCND1
20MP:00053879.6CDC73, VDR, PRKAR1A, MEN1, GNAS, CASR
21MP:00053849.6VDR, PRKAR1A, MEN1, GNAS, CASR, CCND1
22MP:00053859.6LGALS3, CALCA, CCND1, GNAS, MEN1, PTH
23MP:00107689.4VDR, CHGA, PRKAR1A, MEN1, GNAS, CASR

Publications for Parathyroid Adenoma

About this section
Sources:
50PubMed
See all sources

Articles related to Parathyroid Adenoma:

(show top 50)    (show all 614)
idTitleAuthorsYear
1
Coexistence of testicular microlithiasis with parathyroid adenoma in an obese child. (24030026)
2014
2
Spindle epithelial tumor with thymus-like differentiation of the thyroid (SETTLE): Report of two cases (one associated with a parathyroid adenoma). (22154337)
2013
3
A comparison of minimally invasive video-assisted parathyroidectomy and traditional parathyroidectomy for parathyroid adenoma. (23901344)
2013
4
Evidence of a stabilizing mutation of I^-catenin encoded by CTNNB1 exon 3 in a large series of sporadic parathyroid adenomas. (22576020)
2012
5
An unusual association of cerebral schwannoma, parathyroid adenoma, and papillary thyroid carcinoma. (22856482)
2012
6
Morphological evaluation of parathyroid adenomas and immunohistochemical analysis of PCNA and Ki-67 proliferation markers. (21935871)
2011
7
Parathyroid adenoma with hypertensive crisis and intracerebral hemorrhage mimicking hemolysis, elevated liver enzymes, low platelets syndrome. (21252803)
2011
8
Minimally invasive resection of mediastinal parathyroid adenoma using SPECT/CT and intact PTH monitoring. (21842464)
2011
9
Parathyroid adenoma and chondrosarcoma after treatment of pediatric Hodgkin disease. (20736843)
2010
10
Beta-catenin activation is not involved in sporadic parathyroid carcinomas and adenomas. (19755524)
2010
11
Successful removal of intrathyroidal parathyroid adenoma diagnosed and accurately located preoperatively by parathyroid scintigraphy (SPECT-CT). (21188066)
2010
12
Ectopic (mediastinal) parathyroid adenoma with prominent lymphocytic infiltration. (19115487)
2009
13
Role of single photon emission computed tomography/computed tomography in localization of ectopic parathyroid adenoma: a pictorial case series and review of the current literature. (19617725)
2009
14
Parathyroid fine-needle aspiration cytology in the evaluation of parathyroid adenoma: cytologic findings from 53 patients. (19283690)
2009
15
Regulation of vitamin D receptor function in MEN1-related parathyroid adenomas. (19729047)
2009
16
Synchronous parathyroid adenoma and thyroid papillary carcinoma: a case report. (20062698)
2009
17
Mediastinal parathyroid adenoma. (19736482)
2009
18
Giant parathyroid adenoma. (19183396)
2009
19
Dual phase MIBI scintigraphy in diagnosis of parathyroid adenoma followed by ultrasound guided percutaneous alcoholic ablation. (19610543)
2008
20
Recurrence of primary hyperparathyroidism following spontaneous remission with intracapsular hemorrhage of a parathyroid adenoma. (18470672)
2008
21
Outpatient video-assisted thoracoscopic surgery (VATS) for ectopic mediastinal parathyroid adenoma: a case report and review of the literature. (18503371)
2008
22
Solitary parathyroid adenoma: a rare cause of primary hyperparathyroidism in children. (17473702)
2007
23
A large intrathyroidal parathyroid adenoma presenting as a cold lesion on thyroid scintigraphy. (17314609)
2007
24
Risk of parathyroid adenomas in patients with thyrotoxicosis exposed to radioactive iodine. (17118839)
2006
25
An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma. (16724700)
2006
26
Existence and anatomic distribution of double parathyroid adenoma. (15933536)
2005
27
Increased sensitivity and confidence of SPECT over planar imaging in dual-phase sestamibi for parathyroid adenoma detection. (15604957)
2005
28
Asymptomatic intrathyroidal parathyroid adenoma. Report of a case with a cytologic differential diagnosis including thyroid neoplasms. (15192966)
2004
29
Multiple endocrine neoplasia type 1 parathyroid adenoma development over time. (15490065)
2004
30
Parathyroid adenoma without hyperparathyroidism. (15078912)
2004
31
"Disappearing" mediastinal parathyroid adenoma: retention at the tip of an intrathoracic catheter. (15483494)
2004
32
A difficult case of mediastinal parathyroid adenoma: theoretical and clinical considerations. (15739675)
2004
33
Spontaneous infarction of a parathyroid adenoma: two case reports and review of the literature. (11842966)
2002
34
Technetium-99m methoxyisobutylisonitrile imaging for parathyroid adenoma: relationship to P-glycoprotein or multidrug resistance-related protein expression. (12173014)
2002
35
Effect of parathyroid adenoma excision on interleukin-6 (IL-6) and IL-2 receptor levels. (10690943)
2000
36
Median sternotomy for parathyroid adenoma. (10098336)
1999
37
Parathyroid hyperplasia, adenomas, and carcinomas: differential expression of p27Kip1 protein. (10078919)
1999
38
Relationship between Ca-dependent change of serum PTH and extracellular Ca2+-sensing receptor expression in parathyroid adenoma. (10024390)
1999
39
Location of a small mediastinal parathyroid adenoma using Tc-99m MIBI SPECT. (9509943)
1998
40
Primary hyperparathyroidism caused by a functional parathyroid adenoma in a horse. (9638193)
1998
41
Plasma chromogranin A in pheochromocytoma, primary hyperparathyroidism and pituitary adenoma in comparison with catecholamine, parathyroid hormone and pituitary hormones. (9228469)
1997
42
Spontaneous vocal cord paresis and return to normocalcemia: an unusual presentation of parathyroid adenoma with concomitant abscess. (9186472)
1997
43
Differences in PTH (1-84) release in response to ambient calcium concentrations of parathyroid adenoma fragments and dispersed parathyroid adenoma cells in culture. (8844452)
1996
44
Cyclin D1/PRAD1 expression in parathyroid adenomas: an immunohistochemical study. (8626826)
1996
45
Absence of cyclin D1/PRAD1 point mutations in human breast cancers and parathyroid adenomas and identification of a new cyclin D1 gene polymorphism. (7621424)
1995
46
Hyperprolactinemia caused by lactation and pituitary adenomas is associated with altered serum calcium, phosphate, parathyroid hormone (PTH), and PTH-related peptide levels. (7559893)
1995
47
Clonal analysis of parathyroid adenomas by means of the polymerase chain reaction. (7910112)
1994
48
Light microscopical immunohistochemical study on parathyroid adenoma in primary hyperparathyroidism. (7515533)
1994
49
Multiple endocrine neoplasia. Pituitary adenoma, multicentric papillary thyroid carcinoma, bilateral carotid body paraganglioma, parathyroid hyperplasia, gastric leiomyoma, and systemic amyloidosis. (7137085)
1982
50
Multicentric thyroid carcinoma, parathyroid adenomas, and vagal neurilemmoma in a young man with antecedent tonsillar radiation. (7412405)
1980

Genetic Variations for Parathyroid Adenoma

About this section

Expression for genes affiliated with Parathyroid Adenoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Parathyroid Adenoma

Search GEO for disease gene expression data for Parathyroid Adenoma.

Pathways for genes affiliated with Parathyroid Adenoma

About this section
Sources:
12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 4Cell Signaling Technology
See all sources

Pathways related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.3PTH, VDR
2
Hide members
10.3MEN1, CDKN1B, CDKN2C
3
Hide members
10.3CDKN2C, CDKN1B, CCND1
4
Hide members
10.2CDKN2C, CDKN1B, CDC73, CCND1
5
Hide members
10.2CCND1, CDKN1B, CDKN2C, FGFR2
6
Hide members
10.2CDKN1B, VDR, PRKAR1A, GNAS
7
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
10.0PTH, CCND1, GNAS, PRKAR1A, VDR, PTHLH
8
Hide members
9.8CALCA, CASR, GNAS, MEN1, PRKAR1A, CDKN1B

Compounds for genes affiliated with Parathyroid Adenoma

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Parathyroid Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 136)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8VDR
2forskolin44 49 1112.7PTH, CALCA, PRKAR1A
3glutamate4410.7CASR, PRKAR1A, GNAS
422-oxacalcitriol4410.6ALPP, PTHLH, VDR, CASR
5calcium carbonate4410.5CALCA, ALPP, PTH, PTHLH
6pamidronate44 49 1112.5ALPP, PTH, CASR, CALCA, PTHLH
7cinacalcet44 28 1112.5CALCA, CASR, PRKAR1A, CXADR
8alendronate44 49 1112.5VDR, CALCA, PTHLH, PTH, ALPP
925-hydroxyvitamin d4410.5CASR, CALCA, VDR, ALPP, PTHLH, PTH
10phosphorus4410.5CALCA, CASR, VDR, PTHLH, PTH, ALPP
11deoxypyridinoline4410.4PTH, VDR, CALCA
12eb 108944 5911.4CCND1, CDKN1B, PTHLH, VDR
13bromodeoxyuridine4410.4FGFR2, PTHLH, CDKN1B, PTH, CCND1, CHGA
14neomycin4410.4CASR, PRKAR1A, ALPP, PTHLH, CXADR
15acth4410.4CASR, GNAS, CHGA, CHGB, LGALS3
16l-amino acid4410.4PRKAR1A, CHGA, CXADR, CASR
17etidronic acid44 49 1112.3ALPP, VDR, CALCA
181,25 dihydroxy vitamin d34410.3CALCA, CASR, ALPP, VDR, CDKN1B, CXADR
19dexamethasone44 49 28 1113.3ALPP, CHGB, ABCB1, VDR, CDKN1B, CXADR
20calcitriol44 59 11 2413.3PTH, ALPP, CASR, VDR, CDKN1B, CALCA
21guanine44 11 2412.3CCND1, GNAS, CHGA, VDR, CALCA, FGFR2
22agar4410.3FGFR2, RET, CDKN1B, PTHLH, CCND1, LGALS3
23ribonucleic acid4410.3PTHLH, RET, FGFR2, CHGA, GNAS, CXADR
24tamoxifen44 49 28 1113.2CDKN1B, FGFR2, ABCB1, CHGA, PTH, ALPP
25paraffin4410.2PTHLH, CHGA, CDKN1B, LGALS3, ALPP, RET
26cyclic amp44 2411.2CDKN1B, PTHLH, GNAS, CASR, RET, CHGA
27steroid4410.2GNAS, PRKAR1A, VDR, FGFR2, CXADR, CCND1
28genistein44 28 59 2 11 2415.2ABCB1, CCND1, CDKN1B, RET, FGFR2, VDR
29progesterone44 59 28 11 2414.2GNAS, PTHLH, ABCB1, FGFR2, CDKN1B, CHGA
30cisplatin44 49 59 1113.2FGFR2, CXADR, ABCB1, PTHLH, LGALS3, CHGA
31thymidine44 2411.2CXADR, ALPP, PTH, PTHLH, MEN1, FGFR2
3224,25-dihydroxyvitamin d34410.1ALPP, VDR, CALCA
33creatinine4410.1PTHLH, ALPP, PTH, CASR, CHGA, VDR
34threonine4410.1CDKN1B, CDKN2C, RET, FGFR2, PTHLH, LGALS3
35nitric oxide44 11 2412.1CXADR, CASR, CHGA, CDKN1B, CALCA, FGFR2
36adenylate4410.1GNAS, CASR, CALCA, CCND1, PRKAR1A, CHGA
37paclitaxel44 49 1112.1CDKN1B, CCND1, ABCB1, CHGA, FGFR2
38serine4410.1CDKN2C, RET, CXADR, CCND1, ALPP, CDKN1B
39vegf4410.1LGALS3, PTH, PTHLH, FGFR2, RET, CDKN1B
40alanine4410.1PTHLH, CASR, GNAS, VDR, ALPP, CDKN1B
41testosterone44 59 11 2413.1FGFR2, CCND1, VDR, CALCA, CHGA, ALPP
42vitamin d4410.0VDR, ALPP, PTHLH, PTH, LGALS3, CXADR
43retinoic acid44 2411.0LGALS3, CXADR, ALPP, PTHLH, CHGA, CCND1
44cycloheximide4410.0ALPP, PTH
45oligonucleotide4410.0CDKN1B, CHGB, RET, GNAS, CCND1, FGFR2
46norepinephrine44 11 2412.0CALCA, PTHLH, CHGB, CHGA, ALPP, GNAS
47cysteine4410.0CXADR, ALPP, CASR, GNAS, LGALS3, FGFR2
48tyrosine449.9CHGA, PTHLH, PTH, LGALS3, FGFR2, RET
49arginine449.9PRKAR1A, CASR, GNAS, CHGA, CDKN1B, ALPP
50calcium44 49 11 2412.8GNAS, CHGA, RET, PRKAR1A, ALPP, VDR

GO Terms for genes affiliated with Parathyroid Adenoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.9PTHLH, CXADR, FGFR2, CHGB, CHGA, GNAS

Biological processes related to Parathyroid Adenoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1cAMP metabolic processGO:04605810.4PTHLH, PTH
2adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.3CALCA, PTHLH, PTH
3positive regulation of cAMP biosynthetic processGO:03081910.3CALCA, GNAS, PTHLH, PTH
4skeletal system developmentGO:00150110.3LGALS3, PTH, PTHLH, VDR
5negative regulation of cell proliferationGO:00828510.2PTHLH, FGFR2, CDKN2C, CDKN1B, CDC73, VDR
6negative regulation of transcription from RNA polymerase II promoterGO:00012210.1PTH, FGFR2, CDC73, VDR, MEN1
7cell-cell signalingGO:00726710.1PTH, PTHLH, FGFR2, CALCA
8cellular calcium ion homeostasisGO:00687410.0CASR, VDR, PTH

Molecular functions related to Parathyroid Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.3CDKN2C, CDKN1B
2hormone activityGO:00517910.1CALCA, CHGB, PTHLH, PTH
3peptide hormone receptor bindingGO:05142810.1PTH, PTHLH
4protein bindingGO:0055159.3LGALS3, CCND1, CALCA, CASR, GNAS, MEN1

Products for genes affiliated with Parathyroid Adenoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Parathyroid Adenoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet