Parathyroid Carcinoma malady

Wikipedia: Parathyroid carcinoma is a rare malignant neoplasm resulting in parathyroid adenoma to carcinoma...⁴⁴ more...

MalaCards: Parathyroid Carcinoma, also known as parathyroid neoplasms, is related to squamous cell carcinoma and papillary thyroid carcinoma. An important gene associated with Parathyroid Carcinoma is CDC73 (cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)), and among its related pathways are Pancreatic cancer and p53 Signaling. The drugs carmustine and prednisone and the compounds vincristine and pamidronate have been mentioned in the context of this disorder. Affiliated tissues include the parathyroid gl and thyroid, and related mouse phenotypes are respiratory system and limbs/digits/tail.

Disease Ontology: An endocrine gland cancer located in the parathyroid glands located in the neck.⁶

OMIM: 608266

Aliases & Descriptions:

parathyroid carcinoma 6 7 30 8 33 32 parathyroid neoplasms 32 43 parathyroid cancer 30 32 malignant tumor of parathyroid gland (disorder) 6 malignant neoplasm of parathyroid gland 6 malignant neoplasm of the parathyroid 6 parathyroid gland adenocarcinoma 43 carcinoma of parathyroid gland 6

neoplasm of parathyroid gland 6 parathyroid gland neoplasm 6 parathyroid gland cancer 6 parathyroid neoplasm 6 malignant neoplasms 43 carcinoma 43 neoplasms 43

Diseases related to parathyroid carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1892)

id	Related Disease	Score	Top Affiliating Genes
1	squamous cell carcinoma	40.9	LGALS3, MKI67, CCND1
2	papillary thyroid carcinoma	36.2	RET, LGALS3, MEN1, CCND1, CALCA
3	renal cell carcinoma	36.2	RB1, LGALS3, UCHL1, MKI67, CCND1, TP53
4	breast carcinoma	35.3	RB1, BRCA2, LGALS3, MKI67, CCND1, CALCA
5	oral squamous cell carcinoma	35.0	RB1, MKI67, CCND1, TP53, TERT, KRT14
6	colon carcinoma	34.6	LGALS3, MKI67, GSK3B, MEN1, CCND1, CASR
7	hepatocellular carcinoma	34.4	RET, RB1, BRCA2, SCT, LGALS3, UCHL1
8	nasopharyngitis	34.4	RB1, UCHL1, MKI67, CCND1, TP53, TERT
9	ovarian carcinoma	34.4	RB1, BRCA2, LGALS3, MKI67, CCND1, CALCA
10	renal carcinoma	34.0	LGALS3, MKI67, MEN1, CCND1, TP53
11	adenoid cystic carcinoma	33.6	LGALS3, MKI67, CCND1, TP53, KRT14
12	neuroendocrine carcinoma	33.4	MKI67, MEN1, CALCA, TP53
13	endometrial carcinoma	33.3	RB1, BRCA2, CGB5, MKI67, GSK3B, CCND1
14	non-small cell lung carcinoma	33.3	RB1, LGALS3, MKI67, CCND1, TP53, TERT
15	esophageal squamous cell carcinoma	33.2	RB1, BRCA2, LGALS3, CGB5, MKI67, CCND1
16	mucoepidermoid carcinoma	33.2	MKI67, CALCA, KRT14
17	familial medullary thyroid carcinoma	33.2	RET, CALCA
18	adrenocortical carcinoma	33.1	RB1, MEN1, CALCA, TP53
19	basal cell carcinoma	33.1	LGALS3, MKI67, GSK3B, CCND1, TP53, TERT
20	bladder carcinoma	32.9	RB1, LGALS3, CGB5, MKI67, CCND1, TP53
21	squamous cell carcinoma of the head and neck	32.9	MKI67, CCND1, TP53, TERT
22	laryngeal squamous cell carcinoma	32.7	RB1, LGALS3, MKI67, CCND1, TP53, TERT
23	adenoiditis	32.4	LGALS3, MKI67, CCND1, TP53, TERT, KRT14
24	small cell carcinoma	32.3	RB1, BRCA2, SCT, MKI67, CCND1, CALCA
25	tongue cancer	32.2	MKI67, TP53, TERT
26	laryngitis	32.0	RB1, BRCA2, LGALS3, CGB5, MKI67, CCND1
27	liver cirrhosis	31.5	RB1, SCT, LGALS3, CASR, TP53
28	bile duct carcinoma	31.3	CCND1, TP53, TERT
29	renal oncocytoma	31.0	CCND1, TP53, KRT14
30	esophagitis	31.0	RET, RB1, BRCA2, SCT, LGALS3, UCHL1
31	peritoneal carcinoma	30.9	RET, BRCA2, TP53
32	pleomorphic carcinoma	30.7	CGB5, TP53, KRT14
33	multiple endocrine neoplasia type 2a	30.6	RET, CDC73, MEN1, CALCA, PTH
34	basaloid squamous cell carcinoma	30.6	MKI67, TP53, KRT14
35	cervicitis	30.6	RET, RB1, BRCA2, LGALS3, UCHL1, UCHL5
36	hyperparathyroidism-jaw tumor syndrome	30.4	CDC73, CASR
37	hypoxia	30.4	RET, RB1, LGALS3, CGB5, MKI67, GSK3B
38	keratoacanthoma	30.4	UCHL1, MKI67, TP53, KRT14
39	prostatitis	30.3	RET, RB1, BRCA2, LGALS3, UCHL1, B3GALT2
40	cushing's syndrome	30.2	RET, MEN1, CALCA
41	ovarian cancer	29.9	RB1, BRCA2, CCND1
42	follicular adenoma	29.8	RET, LGALS3, CALCA
43	keratosis	29.6	RB1, MKI67, TP53, KRT14
44	actinic keratosis	29.5	RB1, MKI67, TP53
45	pleomorphic adenoma	29.5	MKI67, CCND1, TP53, TERT, KRT14
46	goiter	29.4	RET, LGALS3, CALCA, PTH
47	myoma	29.4	CCND1, CALCA, TERT
48	thyroid medullary carcinoma	29.4	RET, MKI67, CALCA, TP53
49	pancreatitis	29.3	RET, RB1, BRCA2, SCT, LGALS3, UCHL1
50	familial adenomatous polyposis	29.2	RB1, GSK3B, CCND1, TP53

Clinical features from OMIM: 608266

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carmustine, dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], diethylstilbestrol, diethylstilbestrol diphosphate, linolenic acid, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, nilutamide, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

MalaCards organs/tissues related to parathyroid carcinoma:

²²

FMA organs/tissues related to parathyroid carcinoma:

¹¹

MGI Mouse Phenotypes related to parathyroid carcinoma:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.9	CALCA, CDC73, RET
2	limbs/digits/tail phenotype	MP:0005371	8.2	PTH, TP53, UCHL1, BRCA2, RB1, RET
3	tumorigenesis	MP:0002006	7.9	KRT14, TERT, TP53, CCND1, MEN1, BRCA2
4	embryogenesis phenotype	MP:0005380	7.9	CALCA, MEN1, CDC73, UCHL5, BRCA2, RB1
5	digestive/alimentary phenotype	MP:0005381	7.8	RET, KRT14, TERT, CASR, MEN1, CDC73
6	renal/urinary system phenotype	MP:0005367	7.7	TP53, CALCA, CASR, GSK3B, CDC73, UCHL1
7	cardiovascular system phenotype	MP:0005385	7.7	PTH, TP53, CALCA, CCND1, MEN1, CDC73
8	skeleton phenotype	MP:0005390	7.6	PTH, TERT, TP53, CALCA, CASR, CCND1
9	behavior/neurological phenotype	MP:0005386	7.5	CALCA, CASR, GSK3B, CDC73, B3GALT2, UCHL1
10	integument phenotype	MP:0010771	7.5	KRT14, TP53, CALCA, CASR, CCND1, CDC73
11	reproductive system phenotype	MP:0005389	7.2	RTP2, KRT14, TERT, TP53, CCND1, MEN1
12	hematopoietic system phenotype	MP:0005397	7.1	CASR, TP53, TERT, PTH, CCND1, CDC73
13	immune system phenotype	MP:0005387	7.0	TP53, TERT, PTH, KRT14, CASR, CCND1
14	endocrine/exocrine gland phenotype	MP:0005379	6.9	PTH, TERT, TP53, CASR, CCND1, MEN1
15	cellular phenotype	MP:0005384	6.8	CCND1, CASR, TP53, TERT, KRT14, MEN1
16	mortality/aging	MP:0010768	6.2	MEN1, CCND1, CASR, TP53, PTH, KRT14
17	growth/size phenotype	MP:0005378	6.1	MEN1, CCND1, CASR, TP53, TERT, PTH
18	homeostasis/metabolism phenotype	MP:0005376	5.8	CCND1, CASR, CALCA, TP53, TERT, KRT14
19	nervous system phenotype	MP:0003631	5.7	GSK3B, MEN1, CCND1, CALCA, TP53, TERT

Articles related to parathyroid carcinoma:

(show all 32)

id	Title	Authors	Year	Affiliating Genes
1	High third generation/second generation PTH ratio in a patient with parathyroid carcinoma: clinical utility of third generation/seco nd generation PTH ratio in patients with primary hyperparathyroidism. (18782355)	Caron P.... Souberbielle J.C.	2009	PTH
2	Parathyroid carcinoma in multiple endocrine neoplasia type 1 with a classic germline mutation. (19491073)	Shih R.Y.... Wells D.	2009	MEN1, SCT
3	Diagnosis of parathyroid carcinoma using immunohistoc hemical staining against hTERT. (19885612)	Osawa N.... Hirakawa K.	2009	TERT
4	Loss of expression for the Wnt pathway components adenomatous polyposis coli and glycogen synthase kinase 3-beta in parathyroid carcinomas. (19148484)	Juhlin C.C.... HAPAPg A.	2009	GSK3B, CDC73
5	Accuracy of combined protein gene product 9.5 and parafibromin markers for immunohistochemical diagnosis of parathyroid carcinoma. (19017757)	Howell V.M.... Marsh D.J.	2009	UCHL1, CDC73
6	Human chorionic gonadotropin measurements in parathyroid carcinoma. (18625691)	Rubin M.R.... Silverberg S.J.	2008	CGB5
7	Challenging lesions in the differential diagnosis of endocrine tumors: parathyroid carcinoma. (19058032)	DeLellis R.A.	2008	CDC73
8	Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroid carcinomas. (17555500)	Haven C.J.... Morreau H.	2007	MEN1, CDC73
9	Aberrant methylation of the HRPT2 gene in parathyroid carcinoma. (18217513)	Hewitt K.M.... Hobbs M.	2007	CDC73
10	Should parafibromin staining replace HRTP2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma? (17468190)	Cetani F.... Marcocci C.	2007	CCND1, CDC73
11	Hyperparathyroidism-jaw tumor syndrome. A hereditary form of primary hyperparathyroidism with parathyroid carcinoma (17583828)	Raue F.... Frank-Raue K.	2007	CDC73
12	Loss of nuclear expression of parafibromin distinguishes parathyroid carcinomas and hyperparathyroidism-jaw tumor (HPT-JT) syndrome-related adenomas from sporadic parathyroid adenomas and hyperplasias. (16931959)	Gill A.J.... Marsh D.J.	2006	CDC73
13	Parathyroid carcinoma. (16357559)	Rodgers S.E.... Perrier N.D.	2006	CDC73
14	Parathyroid carcinoma. (16237743)	Rawat N.... Baxter J.N.	2005	CDC73
15	Galectin-3 expression in parathyroid carcinoma: immunohistochemical study of 26 cases. (16112008)	Bergero N.... Papotti M.	2005	LGALS3, MKI67
16	Parathyroid carcinoma: an overview. (15731573)	DeLellis R.A.	2005	CDC73
17	Parathyroid carcinoma (16444365)	Vieira J.G.... Lazaretti-Castro M.	2005	CDC73
18	Parathyroid carcinoma. (15719375)	Mittendorf E.A.... McHenry C.R.	2005	CDC73
19	Loss of parafibromin immunoreactivity is a distinguishing feature of parathyroid carcinoma. (15475453)	Tan M.H.... Teh B.T.	2004	CDC73
20	Differential expression of the calcium sensing receptor and combined loss of chromosomes 1q and 11q in parathyroid carcinoma. (14694525)	Haven C.J.... Morreau H.	2004	CCND1, CASR, CDC73
21	Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma. (12864795)	Shattuck T.M.... Arnold A.	2003	RB1
22	Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma. (14585940)	Shattuck T.M.... Arnold A.	2003	CDC73
23	Oxyphil parathyroid carcinomas: a clinicopathologic and immunohistochemical study of 10 cases. (11859206)	Erickson L.A.... Lloyd R.V.	2002	KRT14
24	Coexistence of parathyroid carcinoma and non-medullar y carcinoma of the thyroid. (11386024)	Bednarek-Tupikowska G.... Milewicz A.	2001	CALCA
25	Expression of cyclin D1 in parathyroid carcinomas, adenomas, and hyperplasias: a paraffin immunohistochemical study. (10229506)	Vasef M.A.... Robinson R.A.	1999	CCND1
26	Familial isolated primary hyperparathyroidism with parathyroid carcinomas: clinical and molecular features. (9509070)	Yoshimoto K.... Itakura M.	1998	BRCA2
27	Treatment of hypercalcemia secondary to parathyroid carcinoma with a novel calcimimetic agent. (9543122)	Collins M.T.... Marx S.J.	1998	CALCA, CASR
28	Successful treatment by surgical removal of bone meta stasis producing PTH: new approach to the management of metastatic parathyroid carcinoma. (7849385)	Koyano H.... Furui S.	1994	CALCA
29	p53 abnormalities in human parathyroid carcinoma. (8200932)	Cryns V.L.... Arnold A.	1994	TP53
30	Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma. (7906387)	Cryns V.L.... Arnold A.	1994	RB1, CCND1
31	Immunohistological study of nonfunctional parathyroid carcinoma. Report of a case. (1609615)	Yamashita H.... Daa T.	1992	PTH
32	Studies in a kindred with parathyroid carcinoma. (1639936)	Streeten E.A.... Zimering M.B.	1992	PTH

Genes related to parathyroid carcinoma according to GeneCards:

(show all 22)

id	Symbol	Description	Score	GeneCards Section Context
1	CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	11.1	Summaries, Orthologs, Publications
2	MEN1	multiple endocrine neoplasia I	11.0	Publications
3	PTH	parathyroid hormone	11.0	Publications
4	CASR	calcium-sensing receptor	11.0	Publications
5	RET	ret proto-oncogene	11.0
6	CCND1	cyclin D1	11.0	Publications
7	RTP2	receptor (chemosensory) transporter protein 2	11.0
8	B3GALT2	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2	11.0
9	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	11.0	Publications
10	RNF20	ring finger protein 20, E3 ubiquitin protein ligase	11.0
11	KRT14	keratin 14	11.0	Publications
12	SCT	secretin	11.0	Publications
13	UCHL5	ubiquitin carboxyl-terminal hydrolase L5	11.0
14	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
15	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
16	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
17	RB1	retinoblastoma 1	11.0	Publications
18	BRCA2	breast cancer 2, early onset	11.0	Publications
19	TERT	telomerase reverse transcriptase	11.0	Publications
20	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
21	GSK3B	glycogen synthase kinase 3 beta	11.0	Publications
22	TP53	tumor protein p53	11.0	Publications

Pathways related to parathyroid carcinoma according to GeneDecks:

(show all 23)

id	Pathway	Score	Top Affiliating Genes
1	Pancreatic cancer20	10.4	BRCA2
2	p53 Signaling36	10.3	TP53
3	Non-small cell lung cancer20	10.2	RB1
4	Endometrial cancer20	9.9	CCND1, TP53
5	Class B/2 (Secretin family receptors)38	9.9	PTH, CALCA, SCT
6	Thyroid cancer20	9.8	TP53, CCND1, RET
7	Signal transduction AKT signaling10	9.8	GSK3B
8	Colorectal cancer20	9.7	GSK3B
9	Bladder cancer20	9.6	RB1, CCND1, TP53
10	Chronic myeloid leukemia20	9.3	RB1, CCND1, TP53
11	Cell cycle_Regulation of G1/S transition (part 2)41	9.3	CCND1, GSK3B, RB1
12	Cell cycle Regulation of G1/S transition (part 2)10	9.3	CCND1, GSK3B, RB1
13	Glioma20	9.2	TP53, CCND1, RB1
14	BRCA1 Pathway36	9.2	RB1, BRCA2, TP53
15	Signal transduction_AKT signaling41	9.1	TP53, CCND1, GSK3B
16	Melanoma20	9.0	RB1, CCND1, TP53
17	Glioblastoma Multiforme36	9.0	TP53, GSK3B, RB1
18	Cell Cycle / Checkpoint Control3	9.0	TP53, CCND1, CDC73, BRCA2, RB1
19	G1-S Phase Transition36	8.9	RB1, GSK3B, CCND1, TP53
20	Cyclins and Cell Cycle Regulation36	8.9	TP53, CCND1, GSK3B, RB1
21	Prostate cancer20	8.8	RB1, GSK3B, CCND1, TP53
22	Cell cycle20	8.8	RB1, GSK3B, CCND1, TP53
23	Pathways in cancer20	8.2	TP53, CCND1, GSK3B, BRCA2, RB1, RET

Compounds related to parathyroid carcinoma according to GeneDecks:

(show top 50)    (show all 87)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	13.2	CALCA, CGB5
2	pamidronate32 9 9	12.0	CASR, CALCA, PTH
3	gossypol32 42	10.8	RB1, CCND1, CGB5
4	hpvs32	9.6	RB1, KRT14, TP53
5	olomoucine32 42 9 9	12.5	RB1, TP53, CCND1
6	acetone32	9.4	CGB5, MKI67, CCND1
7	sb-21676332	9.3	CCND1, GSK3B
8	1,25 dihydroxy vitamin d332	9.3	PTH, RB1, CASR, CALCA
9	ibmx32	9.3	SCT, CGB5, PTH, CALCA
10	vitamin d32	9.3	KRT14, MEN1, CASR, CALCA, PTH, LGALS3
11	acth32	9.3	CALCA, SCT, LGALS3, CGB5, CASR
12	depsipeptide32	9.2	TERT, CCND1, TP53, RB1
13	dutp32	9.2	CCND1, LGALS3, MKI67, TP53
14	bromodeoxyuridine32	9.1	PTH, KRT14, CCND1, MKI67, RB1
15	ribonucleic acid32	9.1	CASR, PTH, RET, TERT, CGB5
16	calcitriol32 42 9 18 9	13.1	CALCA, PTH, CASR, RB1, TERT
17	pd 98,05932	9.0	TERT, CASR, CCND1, RB1, SCT, RET
18	arginine32	8.9	KRT14, PTH, TERT, CASR, CGB5, RET
19	estradiol32 9 18 9	11.9	CGB5, BRCA2, CCND1, MKI67, RB1
20	cysteine32	8.8	CASR, KRT14, UCHL1, SCT, TERT, LGALS3
21	adpribose32	8.8	TERT, RB1, TP53, BRCA2, CCND1
22	etoposide32 42 9 9	11.7	CGB5, RB1, LGALS3, TP53, TERT
23	adriamycin32	8.7	CCND1, BRCA2, RB1, TP53, TERT
24	lysine32	8.6	UCHL1, RB1, SCT, KRT14, CASR, MKI67
25	genistein32 9 18 9	11.6	RET, CGB5, CCND1, RB1, BRCA2, TERT
26	mitomycin c32	8.6	TP53, RB1, BRCA2, MKI67
27	thymidylate32	8.6	MKI67, TP53, RB1, CCND1, TERT
28	resveratrol32 9 18 9	11.6	BRCA2, RB1, TP53, CCND1
29	forskolin32 42 9 9	11.5	CALCA, PTH, CASR, GSK3B, CGB5, SCT
30	butyrate32	8.4	RET, RB1, LGALS3, CCND1, TP53, TERT
31	tamoxifen32 34 9 9	11.3	KRT14, PTH, BRCA2, CGB5, MKI67, CCND1
32	doxorubicin32 34 9 9	11.2	RB1, CGB5, MKI67, CCND1, TP53, TERT
33	retinoic acid32 42 18	10.2	RET, TERT, CGB5, CCND1, LGALS3, SCT
34	cyclic amp32 18	9.1	CGB5, SCT, GSK3B, RET, CASR, RB1
35	phosphatidylinositol32	7.9	CCND1, TERT, GSK3B, LGALS3, RB1, BRCA2
36	oligonucleotide32	7.9	LGALS3, TERT, CCND1, TP53, BRCA2, RB1
37	nitric oxide32 9 18 9	10.9	PTH, TERT, CALCA, CASR, MKI67, CGB5
38	paclitaxel32 34 9 9	10.8	CGB5, MKI67, CCND1, TP53, TERT, RB1
39	thymidine32 18	8.5	PTH, BRCA2, SCT, MKI67, RB1, MEN1
40	threonine32	7.4	KRT14, TERT, MKI67, LGALS3, RB1, CCND1
41	cisplatin32 34 9 9	10.2	MKI67, TP53, CGB5, TERT, KRT14, CCND1
42	paraffin32	7.0	TP53, LGALS3, BRCA2, KRT14, RB1, RET
43	vegf32	7.0	RET, TERT, TP53, CGB5, RB1, CALCA
44	lipid32	7.0	LGALS3, KRT14, GSK3B, MKI67, CGB5, SCT
45	calcium32 9 18 9	9.9	CALCA, PTH, KRT14, TERT, CASR, MEN1
46	progesterone32 42 9 18 9	10.9	BRCA2, LGALS3, CGB5, MKI67, RB1, GSK3B
47	testosterone32 9 18 9	9.5	BRCA2, RET, PTH, TERT, CALCA, CCND1
48	estrogen32	6.3	CALCA, TERT, TP53, KRT14, CASR, CCND1
49	tyrosine32	6.1	CASR, CCND1, MEN1, SCT, MKI67, UCHL1
50	serine32	5.8	CCND1, KRT14, MEN1, GSK3B, MKI67, TP53

Cellular components related to parathyroid carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	PML body	GO:016605	9.0	RB1, TP53, TERT
2	nucleolus	GO:005730	6.5	BRCA2, KRT14, RNF20, TERT, TP53, MEN1
3	nucleus	GO:005634	5.0	MEN1, CCND1, CALCA, TP53, RNF20, KRT14

Biological processes related to parathyroid carcinoma according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	histone H2B ubiquitination	GO:033523	10.0	CDC73, RNF20
2	neuron maturation	GO:042551	9.9	RET, RB1
3	mitotic cell cycle G1/S transition DNA damage checkpoint	GO:031571	9.8	TP53, CCND1
4	positive regulation of macrophage differentiation	GO:045651	9.8	CALCA, RB1
5	re-entry into mitotic cell cycle	GO:000320	9.6	GSK3B, CCND1
6	response to gamma radiation	GO:010332	9.5	BRCA2, MEN1, TP53
7	ER overload response	GO:006983	8.8	GSK3B, TP53
8	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.3	PTH, TP53, MEN1, GSK3B, CDC73, RB1
9	negative regulation of transcription, DNA-dependent	GO:045892	8.2	TP53, CALCA, MEN1, GSK3B, RB1

Molecular functions related to parathyroid carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ubiquitin protein ligase binding	GO:031625	8.5	RB1, GSK3B, TP53, RNF20
2	protein binding	GO:005515	4.1	RET, KRT14, RNF20, TERT, TP53, CALCA