MCID: PRT010
MIFTS: 63

Parathyroid Carcinoma malady

Cancer, Endocrine categories

Summaries for Parathyroid Carcinoma

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Parathyroid carcinoma is a rare malignant neoplasm resulting in parathyroid adenoma to carcinoma... more...

MalaCards: Parathyroid Carcinoma, also known as parathyroid cancer, is related to adenoma and hypercalcemia. An important gene associated with Parathyroid Carcinoma is CDC73 (cell division cycle 73), and among its related pathways are HTLV-I infection and Cell cycle. The compounds sb-216763 and pamidronate have been mentioned in the context of this disorder. Affiliated tissues include the parathyroid gl, skin and ovary, and related mouse phenotypes are skeleton and respiratory system.

Disease Ontology:8 An endocrine gland cancer located in the parathyroid glands located in the neck.

Description from OMIM:47 608266

Aliases & Classifications for Parathyroid Carcinoma

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 22GTR, 57SNOMED-CT, 40NCIt, 35MeSH, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Endocrine


Characteristics (Orphanet epidemiological data):

49
parathyroid carcinoma:
Prevalence: 1-9/1000000


Aliases & Descriptions:

parathyroid carcinoma 8 9 43 47 10 45 49
parathyroid cancer 43 22 45
malignant tumor of parathyroid gland 8 61
parathyroid neoplasms 45 61
malignant neoplasm of parathyroid gland 8
malignant neoplasm of the parathyroid 8
parathyroid gland adenocarcinoma 61
carcinoma of parathyroid gland 8
neoplasm of parathyroid gland 8
parathyroid gland neoplasm 8
parathyroid gland cancer 8
parathyroid neoplasm 8


External Ids:

Disease Ontology8 DOID:1540
OMIM47 608266
NCIt40 C3313
MeSH35 D010282
ICD10 via Orphanet26 C75.0
SNOMED-CT via Orphanet58 255037004
ICD1025 C75.0

Related Diseases for Parathyroid Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Parathyroid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.9MEN1, SCT, CASR, CALCA, CCND1, RB1
2hypercalcemia30.8CALCA, CASR, SCT, MEN1, CDC73, PTH
3primary hyperparathyroidism30.8CALCA, CASR, SCT, MEN1, CDC73, RET
4multiple endocrine neoplasia30.4CALCA, MEN1, CDC73, RET
5papillary carcinoma30.3CALCA, MKI67, RET, KRT14, LGALS3
6hyperparathyroidism-jaw tumor syndrome29.9CDC73
7thyroiditis29.9CALCA
8osteitis fibrosa29.9CASR, PTH
9familial isolated hyperparathyroidism29.9MEN1, CDC73
10neurofibromatosis29.9KRT14, RET, MEN1
11thyroid medullary carcinoma29.9CALCA, CASR, MEN1, RET, LGALS3
12thyroid cancer29.9CALCA, CASR, RET, TERT, LGALS3
13bone carcinoma10.5
14parathyroid cancer, childhood10.3
15acute pancreatitis10.1
16n syndrome10.1
17thymic carcinoma10.1
18cdc73-related parathyroid carcinoma10.1
19birt-hogg-dube syndrome10.0
20ollier disease10.0
21lung cancer10.0CCND1
22primary hyperoxaluria10.0CASR
23craniopharyngioma10.0KRT14
24multiple myeloma10.0CCND1
25giant cell tumor10.0CALCA
26wilms tumor10.0CDC73
27sipple syndrome10.0B3GALT2
28hirschsprung's disease10.0RET
29gastritis10.0SCT
30liver cirrhosis10.0SCT
31pancreatitis10.0SCT, CASR
32wermer syndrome10.0MEN1, CDC73
33hemangioma10.0RET, MEN1
34vipoma10.0MEN1, SCT
35paget's disease of bone10.0CALCA
36prolactinoma10.0MEN1
37leiomyosarcoma10.0RB1
38hypoparathyroidism familial isolated10.0CASR, PTH
39ductal carcinoma in situ10.0CCND1, KRT14
40glucagonoma10.0MEN1, SCT
41skin cancer10.0KRT14
42bone fracture10.0
43neuroendocrine carcinoma10.0
44polycythemia vera10.0
45amyloid tumor10.0
46polymyalgia rheumatica10.0
47ectopic thymus10.0
48papillary adenoma10.0
49trachea carcinoma10.0
50hypothyroidism, autoimmune10.0

Graphical network of the top 20 diseases related to Parathyroid Carcinoma:



Diseases related to parathyroid carcinoma

Clinical Features for Parathyroid Carcinoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

608266

Drugs & Therapeutics for Parathyroid Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Parathyroid Carcinoma

Drug clinical trials:

Search ClinicalTrials for Parathyroid Carcinoma

Search NIH Clinical Center for Parathyroid Carcinoma

Search CenterWatch for Parathyroid Carcinoma

Genetic Tests for Parathyroid Carcinoma

Sources:
22GTR
See all sources

Genetic tests related to Parathyroid Carcinoma:

id Genetic test Affiliating Genes
1 Parathyroid Carcinoma22

Anatomical Context for Parathyroid Carcinoma

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Parathyroid Carcinoma:

33
Skin, Ovary, Liver, Spinal cord, Brain, Lymph node, Lung, Bone marrow, Thymus, Colon, Pancreas, Thyroid, Breast, Prostate, Cervix, Monocytes, B cells, Endothelial, Temporal lobe, Pancreatic islet, Pituitary

FMA organs/tissues related to Parathyroid Carcinoma:

14
The parathyroid gl

Animal Models for Parathyroid Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Parathyroid Carcinoma

Sources:
51PubMed
See all sources

Articles related to Parathyroid Carcinoma:

(show top 50)    (show all 590)
idTitleAuthorsYear
1
Unusual localization of parathyroid carcinoma in anterior chest wall. (24056572)
2013
2
An unusual combination of parathyroid adenoma, medullary and papillary thyroid carcinoma. (23737320)
2013
3
Parathyroid carcinoma presenting as a hyperparathyroid crisis. (22707898)
2012
4
Parathyroid carcinoma with lung metastasis in a thirteen-year-old girl. (22708102)
2012
5
Cinacalcet for hypercalcemia caused by pulmonary squamous cell carcinoma producing parathyroid hormone-related Peptide. (22379470)
2012
6
Intrathyroidal parathyroid carcinoma in a pediatric patient. (21519840)
2011
7
Parathyroid carcinoma: a 43-year outcome and survival analysis. (21937626)
2011
8
Parathyroid carcinoma arising from four-gland hyperplasia. (21247853)
2011
9
Differential expression of microRNAs in human parathyroid carcinomas compared with normal parathyroid tissue. (19926710)
2010
10
Parathyroid carcinoma. (20510726)
2010
11
Mediastinal parathyroid carcinoma presenting with severe skeletal manifestations. (20237944)
2010
12
Severe Hyperparathyroidism Versus Parathyroid Carcinoma: A clinical dilemma. (21509088)
2010
13
A rare presentation in a case of parathyroid carcinoma. (19810371)
2009
14
Parathyroid carcinoma in multiple endocrine neoplasia type 1 with a classic germline mutation. (19491073)
2009
15
Brown tumors simulating metastases on FDG PET in a patient with parathyroid carcinoma. (18265978)
2008
16
Human chorionic gonadotropin measurements in parathyroid carcinoma. (18625691)
2008
17
Hyperparathyroidism-jaw tumor syndrome. A hereditary form of primary hyperparathyroidism with parathyroid carcinoma]. (17583828)
2007
18
Hypercalcemia induced by ovarian clear cell carcinoma producing all transcriptional variants of parathyroid hormone-related peptide gene during pregnancy. (16956653)
2006
19
Incidental parathyroid adenoma mimicking tumor recurrence in a patient with follicular thyroid carcinoma. (16424689)
2006
20
Results of iterative surgery for persistent and recurrent parathyroid carcinoma. (15933877)
2005
21
Primary hyperparathyroidism: can parathyroid carcinoma be anticipated on clinical and biochemical grounds? Report of nine cases and review of the literature. (15889214)
2005
22
Predicting the presence of parathyroid carcinoma. (15952075)
2005
23
The management of parathyroid carcinoma. (15167044)
2004
24
Higher expression of K-ras is associated with parathyroid hormone-related protein-induced hypercalcaemia in renal cell carcinoma. (11851621)
2001
25
Immunohistochemical detection of parathyroid hormone-related protein in a squamous cell carcinoma arising from mature cystic teratoma causing humoral hypercalcemia of malignancy. (11104629)
2000
26
Multifocal parathyroid carcinoma in subtotal thyroidectomy. (11079593)
2000
27
Parathyroid carcinoma during pregnancy. (11094233)
2000
28
Recurrent clear cell carcinoma of the ovary changing into producing parathyroid hormone-related protein (PTH-rP) with hypercalcemia. (10206422)
1999
29
Detection of disseminated carcinoma cells in bone marrow and peripheral blood in primary breast cancer with RT/PCR of parathyroid hormone-related protein (PTHrP)]. (14518259)
1998
30
Nuclear medicine imaging in a case of hyperfunctioning parathyroid carcinoma associated with a parathyroid adenoma. (8521661)
1995
31
Effects of transforming growth factor-beta on parathyroid hormone-related protein production and ribonucleic acid expression by a squamous carcinoma cell line in vitro. (8194469)
1994
32
Regulation of parathyroid hormone-related protein production in a human lung squamous cell carcinoma line. (7829996)
1994
33
Immunohistological study of nonfunctional parathyroid carcinoma. Report of a case. (1609615)
1992
34
Studies in a kindred with parathyroid carcinoma. (1639936)
1992
35
Metastatic calcification in a patient with malignant parathyroid carcinoma. Correlation of clinical, surgical, radiographic, and scintigraphic findings. (2225672)
1990
36
Two cases of parathyroid carcinoma in patients on long-term hemodialysis. (2392196)
1990
37
Modulation of the production of a parathyroid hormone-like protein in human squamous carcinoma cell lines by interaction with fibroblasts. (2160322)
1990
38
Parathyroid carcinoma in a chronic hemodialysis patient. (2739858)
1989
39
Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene. (3290897)
1988
40
Parathyroid carcinoma of the oxyphil cell type. A report of two cases, light and electron microscopic study. (3978540)
1985
41
Parathyroid carcinoma. A report of five cases. (4014880)
1985
42
Successful combination chemotherapy for metastatic parathyroid carcinoma. (6696578)
1984
43
Parathyroid carcinoma with massive parathyroid hormone production and severe mitral incompetence: report of a case with review of the literature. (6480439)
1984
44
Surgical treatment of ten cases of parathyroid carcinoma: importance of an initial en bloc tumor resection. (6464494)
1984
45
Cytologic features of a functioning parathyroid carcinoma: a case report. (6959463)
1982
46
Multiple endocrine neoplasia. Pituitary adenoma, multicentric papillary thyroid carcinoma, bilateral carotid body paraganglioma, parathyroid hyperplasia, gastric leiomyoma, and systemic amyloidosis. (7137085)
1982
47
Therapy of hypercalcemia due to parathyroid carcinoma with intravenous dichloromethylene diphosphonate. (6211978)
1982
48
Parathyroid carcinoma in familial hyperparathyroidism. (412876)
1977
49
Parathyroid carcinoma; report of a case and review of the literature. (13555942)
1958
50
Parathyroid carcinoma associated with acute parathyroid intoxication. (18125449)
1949

Genetic Variations for Parathyroid Carcinoma

Expression for genes affiliated with Parathyroid Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Parathyroid Carcinoma

Search GEO for disease gene expression data for Parathyroid Carcinoma.

Pathways for genes affiliated with Parathyroid Carcinoma

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Parathyroid Carcinoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Parathyroid Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1sb-2167634510.3GSK3B, CCND1
2pamidronate45 50 1112.3CALCA, CASR, PTH
3gossypol4510.1CCND1, RB1, CGB5
425-hydroxyvitamin d4510.0CALCA, CASR, PTH
51,25 dihydroxy vitamin d34510.0PTH, RB1, CASR, CALCA
6depsipeptide4510.0CCND1
7phosphorus459.9PTH, CASR, CALCA
8acetone459.9MKI67, CGB5, CCND1
9vincristine45 50 1111.9CCND1, CALCA, RB1, MKI67
10calcitriol45 60 11 2412.8PTH, TERT, RB1, CASR, CALCA
11ibmx45 29 6011.8CALCA, SCT, CGB5, PTH
12streptavidin459.8MKI67, CGB5, SCT
13paclitaxel45 50 1111.8CCND1, RB1, CGB5, TERT
14vitamin d459.8CALCA, CASR, MEN1, KRT14, PTH, LGALS3
15dutp459.7CCND1, MKI67, LGALS3
16thymidylate459.7CCND1, RB1, MKI67, TERT
17acth459.7CALCA, CASR, SCT, CGB5, LGALS3
18bromodeoxyuridine459.7CCND1, RB1, MKI67, KRT14, PTH
19ribonucleic acid459.6PTH, TERT, RET, CGB5, CASR
20wortmannin459.6CCND1, CASR, RET, TERT, LGALS3
21glucose459.6CASR, SCT, CGB5, KRT14, PTH
22pd 98,059459.6CCND1, CASR, SCT, RB1, RET, TERT
23formaldehyde45 2410.6LGALS3, MKI67, RB1, CCND1
24adenylate459.6CCND1, CALCA, CASR, SCT, CGB5, PTH
25forskolin45 50 1111.5CALCA, CASR, SCT, CGB5, PTH, GSK3B
26tamoxifen45 50 29 1112.5CCND1, CGB5, MKI67, KRT14, PTH
27lysine459.4KRT14, MKI67, RB1, SCT, UCHL1, CASR
28estradiol45 11 2411.3CCND1, SCT, RB1, CGB5, MKI67, PTH
29thymidine45 2410.3CCND1, SCT, MEN1, RB1, MKI67, TERT
30doxorubicin45 50 1111.3CCND1, RB1, CGB5, MKI67, TERT
31glycogen45 2410.2CCND1, CGB5, MKI67, LGALS3, GSK3B
32oligonucleotide459.2CCND1, SCT, RB1, RET, TERT, LGALS3
33cysteine459.1CASR, UCHL1, SCT, RB1, RET, KRT14
34phosphatidylinositol459.1CCND1, CASR, SCT, RB1, RET, TERT
35genistein45 29 60 2 11 2414.1CCND1, RB1, CGB5, RET, TERT
36atp45 2910.1SCT, RB1, CGB5, RET, PTH, LGALS3
37cisplatin45 50 60 1112.1CCND1, RB1, CGB5, MKI67, KRT14, TERT
38cyclic amp45 2410.1CALCA, CASR, SCT, RB1, CGB5, RET
39progesterone45 60 29 11 2413.0CCND1, RB1, CGB5, MKI67, KRT14, LGALS3
40nitric oxide45 11 2410.9CALCA, CASR, RB1, CGB5, MKI67, TERT
41threonine458.9CCND1, RB1, MKI67, RET, KRT14, TERT
42paraffin458.8CCND1, RB1, CGB5, MKI67, RET, KRT14
43arginine458.7CASR, SCT, CGB5, MKI67, RET, KRT14
44retinoic acid45 249.6CCND1, SCT, RB1, CGB5, MKI67, RET
45lipid458.5SCT, RB1, CGB5, MKI67, RET, KRT14
46vegf458.5RB1, MEN1, CALCA, CCND1, CGB5, MKI67
47testosterone45 60 11 2411.4CCND1, CALCA, SCT, RB1, CGB5, MKI67
48calcium45 50 11 2411.1RB1, MEN1, SCT, CASR, CALCA, CGB5
49serine457.9MEN1, SCT, UCHL1, CASR, CCND1, RB1
50tyrosine457.7GSK3B, CCND1, CASR, UCHL1, SCT, MEN1

GO Terms for genes affiliated with Parathyroid Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Parathyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:0057308.7MEN1, MKI67, RNF20, KRT14, TERT, GSK3B
2nucleusGO:0056347.2GSK3B, CCND1, CALCA, UCHL5, UCHL1, MEN1

Biological processes related to Parathyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1re-entry into mitotic cell cycleGO:00032010.2GSK3B, CCND1
2positive regulation of histone methylationGO:03106210.1RNF20, MEN1
3histone H2B ubiquitinationGO:03352310.0RNF20, CDC73
4histone monoubiquitinationGO:01039010.0RNF20, CDC73
5positive regulation of macrophage differentiationGO:0456519.9CALCA, RB1
6neuron maturationGO:0425519.7RB1, RET

Molecular functions related to Parathyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.9PTH, SCT, CALCA
2omega peptidase activityGO:0082429.6UCHL1, UCHL5
3protein bindingGO:0055156.8GSK3B, CCND1, CALCA, CASR, UCHL5, UCHL1

Products for genes affiliated with Parathyroid Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Parathyroid Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet