MCID: PRT010
MIFTS: 69

Parathyroid Carcinoma malady

Cancer diseases, Endocrine diseases categories

Summaries for Parathyroid Carcinoma

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Parathyroid carcinoma is a rare malignant neoplasm resulting in parathyroid adenoma to carcinoma... more...

MalaCards: Parathyroid Carcinoma, also known as parathyroid cancer, is related to hyperparathyroidism and parathyroid adenoma. An important gene associated with Parathyroid Carcinoma is CDC73 (cell division cycle 73), and among its related pathways are HTLV-I infection and Cell cycle. The compounds sb-216763 and pamidronate have been mentioned in the context of this disorder. Affiliated tissues include the parathyroid gl, thyroid and lung, and related mouse phenotypes are skeleton and respiratory system.

Disease Ontology:8 An endocrine gland cancer located in the parathyroid glands located in the neck.

Description from OMIM:46 608266

Aliases & Classifications for Parathyroid Carcinoma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 22GTR, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
parathyroid carcinoma:
Prevalence: 1-9/1000000


Aliases & Descriptions:

parathyroid carcinoma 8 9 42 46 10 44 48
parathyroid cancer 42 22 44
malignant tumor of parathyroid gland 8 60
malignant neoplasm of parathyroid gland 8
malignant neoplasm of the parathyroid 8
parathyroid gland adenocarcinoma 60
carcinoma of parathyroid gland 8
neoplasm of parathyroid gland 8
parathyroid gland neoplasm 8
parathyroid gland cancer 8
parathyroid neoplasms 60
parathyroid neoplasm 8


External Ids:

Disease Ontology8 DOID:1540
OMIM46 608266
NCIt39 C3313
MeSH34 D010282
ICD10 via Orphanet26 C75.0
SNOMED-CT via Orphanet57 255037004
ICD1025 C75.0

Related Diseases for Parathyroid Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Parathyroid Carcinoma family:

Cdc73-Related Parathyroid Carcinoma

Diseases related to Parathyroid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1hyperparathyroidism31.1CDC73, RET, SCT, CALCA, MEN1, PTH
2parathyroid adenoma30.9CCND1, CALCA, CASR, MEN1, CDC73, RET
3adenoma30.8PTH, CASR, CCND1, TERT, LGALS3, KRT14
4hypercalcemia30.8CALCA, PTH, CDC73, MEN1, SCT, CASR
5primary hyperparathyroidism30.8CALCA, CASR, SCT, MEN1, CDC73, RET
6thyroiditis30.5CALCA
7pancreatitis30.3SCT, CASR
8papillary thyroid carcinoma30.2LGALS3, CCND1, CALCA, RET, MEN1
9papillary carcinoma30.2RET, KRT14, LGALS3, MKI67, CALCA
10hyperparathyroidism-jaw tumor syndrome29.9CDC73
11osteitis fibrosa29.9PTH, CASR
12hypothyroidism29.9CASR, PTH
13neurofibromatosis29.9KRT14, RET, MEN1
14thyroid medullary carcinoma29.9MEN1, CASR, CALCA, RET, LGALS3
15thyroid cancer29.9TERT, CALCA, LGALS3, CASR, RET
16retinoblastoma29.9MKI67, KRT14, CCND1, RB1, TERT, MEN1
17mediastinitis10.5
18bone carcinoma10.5
19parathyroid cancer, childhood10.2
20acute pancreatitis10.1
21thymic carcinoma10.1
22cdc73-related parathyroid carcinoma10.1
23lung cancer10.0CCND1
24primary hyperoxaluria10.0CASR
25craniopharyngioma10.0KRT14
26multiple myeloma10.0CCND1
27giant cell tumor10.0CALCA
28sipple syndrome10.0B3GALT2
29wilms tumor10.0CDC73
30hirschsprung's disease10.0RET
31gastritis10.0SCT
32liver cirrhosis10.0SCT
33wermer syndrome10.0CDC73, MEN1
34hemangioma10.0RET, MEN1
35familial isolated hyperparathyroidism10.0CDC73, MEN1
36vipoma10.0SCT, MEN1
37prolactinoma10.0MEN1
38paget's disease of bone10.0CALCA
39leiomyosarcoma10.0RB1
40hypoparathyroidism familial isolated10.0CASR, PTH
41ductal carcinoma in situ10.0CCND1, KRT14
42glucagonoma10.0MEN1, SCT
43leukoplakia10.0MKI67
44calcinosis10.0PTH, CASR
45rhabdomyosarcoma10.0RB1
46deficiency anemia10.0PTH, CGB5
47insulin resistance10.0GSK3B
48chordoma10.0LGALS3, KRT14
49uremia10.0CASR, MEN1, PTH
50measles10.0SCT

Graphical network of the top 20 diseases related to Parathyroid Carcinoma:



Diseases related to parathyroid carcinoma

Clinical Features for Parathyroid Carcinoma

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46OMIM
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Clinical features from OMIM:

608266

Drugs & Therapeutics for Parathyroid Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Parathyroid Carcinoma

Drug clinical trials:

Search ClinicalTrials for Parathyroid Carcinoma

Search NIH Clinical Center for Parathyroid Carcinoma

Search CenterWatch for Parathyroid Carcinoma

Genetic Tests for Parathyroid Carcinoma

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22GTR
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Genetic tests related to Parathyroid Carcinoma:

id Genetic test Affiliating Genes
1 Parathyroid Carcinoma22

Anatomical Context for Parathyroid Carcinoma

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Parathyroid Carcinoma:

32
Thyroid, Lung, Bone, Breast, Liver, Prostate, Lymph node, Pituitary, Colon, Skin, Pancreas, Endothelial, Monocytes, Testes, Thymus, Bone marrow, Brain, Spinal cord, Ovary, Cervix

FMA organs/tissues related to Parathyroid Carcinoma:

14
The parathyroid gl

Animal Models for Parathyroid Carcinoma or affiliated genes

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36MGI
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Publications for Parathyroid Carcinoma

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50PubMed
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Articles related to Parathyroid Carcinoma:

(show top 50)    (show all 589)
idTitleAuthorsYear
1
Parathyroid Carcinoma in the Setting of Tertiary Hyperparathyroidism after Renal Transplant. (24234965)
2013
2
The Third/Second Generation PTH Assay Ratio as a Marker for Parathyroid Carcinoma: Evaluation Using an Automated Platform. (24423313)
2013
3
FDG-anorectic parathyroid carcinoma with FDG-avid bone metastasis on PET/CT images. (24089062)
2013
4
Denosumab for Management of Parathyroid Carcinoma-Mediated Hypercalcemia. (24178790)
2013
5
Parathyroid carcinoma: the importance of high clinical suspicion for a correct management. (23050135)
2012
6
Biomarkers of parathyroid carcinoma. (23001705)
2012
7
Parathyroid carcinoma as a challenging diagnosis: report of three cases. (22908071)
2012
8
Hypercalcaemia due to parathyroid carcinoma presenting in the third trimester of pregnancy. (22188427)
2012
9
Sensitivity of HRPT2 mutation screening to detect parathyroid carcinoma and atypical parathyroid adenoma of Thai patients. (21717873)
2011
10
Nontruncated amino-terminal parathyroid hormone overproduction in two patients with parathyroid carcinoma: a possible link to HRPT2 gene inactivation. (21521290)
2011
11
Parafibromin as a diagnostic instrument for parathyroid carcinoma-lone ranger or part of the posse? (21197463)
2010
12
Parathyroid carcinoma. (19172564)
2009
13
Dual-phase 99mTc-MIBI parathyroid imaging reveals synchronous parathyroid adenoma and papillary thyroid carcinoma: a case report. (19181586)
2008
14
Challenging lesions in the differential diagnosis of endocrine tumors: parathyroid carcinoma. (19058032)
2008
15
Parathyroid carcinoma presenting as a giant mediastinal retrotracheal functioning cyst. (17975683)
2007
16
Normocalcemic parathyroid carcinoma: an unusual clinical presentation. (16504029)
2006
17
Metastatic calcifications and severe hypercalcemia in a patient with parathyroid carcinoma. (16957413)
2006
18
Parathyroid carcinoma]. (16444365)
2005
19
Parathyroid carcinoma should be suspected in dialysis patients with rapid changes in serum parathormone levels. (15770934)
2005
20
Prognostic value of immunocytochemical determination of parathyroid hormone-related peptide expression in cells of mammary ductal carcinoma. Analysis of 7 years of the disease course. (12647214)
2003
21
Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma. (14585940)
2003
22
Hypercalcemia and acute renal failure caused by production of parathyroid hormone-related protein from renal cell carcinoma. (12028689)
2002
23
Thyroid carcinoma found at parathyroidectomy: association with parathyroid carcinoma. (12394140)
2002
24
Hypercalcemia associated with parathyroid hormone-related protein at the terminal stage of uncomplicated squamous cell carcinoma in the head and neck region. (11774403)
2002
25
Metachronous primary hyperparathyroidism due to a parathyroid adenoma and a subsequent carcinoma: report of a case. (11759885)
2001
26
A newly recognized germline mutation of MEN1 gene identified in a patient with parathyroid adenoma and carcinoma. (10963041)
2000
27
Dendritic cell immuno-therapy in disseminated parathyroid carcinoma. (10210012)
1999
28
Parathyroid hormone related protein and carcinoma of the penis: paraneoplastic hypercalcemia. (10210405)
1999
29
Parathyroid hormone-related protein is an independent prognostic factor for renal cell carcinoma. (10491530)
1999
30
Parathyroid carcinoma secondary to prolonged hyperplasia in chronic renal failure and in coeliac disease. (10188867)
1999
31
Parathyroid carcinoma: sixteen new cases and suggestions for correct management. (9841748)
1998
32
Successful resection of hepatic and pulmonary metastases in a patient with parathyroid carcinoma. (8609702)
1996
33
Technetium-99m MIBI uptake in recurrent parathyroid carcinoma and brown tumors. (7738654)
1995
34
Tc-99m sestamibi uptake by parathyroid carcinoma. False-positive localization of parathyroid adenoma. (7586884)
1995
35
Humoral hypercalcemia of hepatocellular carcinoma associated with elevated levels of parathyroid-hormone-related-peptide. (15251588)
1995
36
Parathyroid carcinoma: the relationship of nuclear DNA content to clinical outcome. (8441964)
1993
37
Surgical and medical management of patients with pulmonary metastasis from parathyroid carcinoma. (8256207)
1993
38
Common expression of parathyroid hormone-related protein and no correlation of calcium level in renal cell carcinomas. (8467460)
1993
39
Primary hyperparathyroidism secondary to parathyroid carcinoma: report of a case. (8515201)
1993
40
Mucin-producing parathyroid carcinoma. (1581111)
1992
41
Nonfunctioning parathyroid carcinoma. (1647716)
1991
42
Parathyroid carcinoma: clinical presentation and treatment. (2240416)
1990
43
Synchronous occurrence of parathyroid carcinoma and adenoma in an elderly woman. (2814826)
1989
44
Concurrent primary parathyroid hyperplasia and parathyroid carcinoma. (6687992)
1983
45
Parathyroid carcinoma, adenoma and hyperplasia in a case of chronic renal insufficiency on dialysis. (7140028)
1982
46
Light and electron microscopic investigation of parathyroid carcinoma during dedifferentiation. Survey and study of a case. (7445424)
1980
47
Parathyroid carcinoma with tracheal invasion and airway obstruction. (7350715)
1980
48
Hyperfunctioning parathyroid carcinoma presenting as acute pancreatitis in pregnancy. (7411530)
1980
49
Parathyroid carcinoma. A case report. (1007795)
1976
50
Fatal recurrence of parathyroid carcinoma after seven years. (14017871)
1962

Genetic Variations for Parathyroid Carcinoma

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Expression for genes affiliated with Parathyroid Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Parathyroid Carcinoma

Search GEO for disease gene expression data for Parathyroid Carcinoma.

Pathways for genes affiliated with Parathyroid Carcinoma

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology
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Compounds for genes affiliated with Parathyroid Carcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Parathyroid Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1sb-2167634410.3GSK3B, CCND1
2pamidronate44 49 1112.3CALCA, CASR, PTH
3gossypol4410.1CCND1, RB1, CGB5
425-hydroxyvitamin d4410.0CALCA, CASR, PTH
51,25 dihydroxy vitamin d34410.0PTH, RB1, CASR, CALCA
6depsipeptide4410.0CCND1
7phosphorus449.9PTH, CASR, CALCA
8acetone449.9MKI67, CGB5, CCND1
9vincristine44 49 1111.9CCND1, CALCA, RB1, MKI67
10calcitriol44 59 11 2412.8PTH, TERT, RB1, CASR, CALCA
11ibmx44 28 5911.8CALCA, SCT, CGB5, PTH
12streptavidin449.8MKI67, CGB5, SCT
13paclitaxel44 49 1111.8CCND1, RB1, CGB5, TERT
14vitamin d449.8CALCA, CASR, MEN1, KRT14, PTH, LGALS3
15dutp449.7CCND1, MKI67, LGALS3
16thymidylate449.7CCND1, RB1, MKI67, TERT
17acth449.7CALCA, CASR, SCT, CGB5, LGALS3
18bromodeoxyuridine449.7CCND1, RB1, MKI67, KRT14, PTH
19ribonucleic acid449.6PTH, TERT, RET, CGB5, CASR
20wortmannin449.6CCND1, CASR, RET, TERT, LGALS3
21glucose449.6CASR, SCT, CGB5, KRT14, PTH
22pd 98,059449.6CCND1, CASR, SCT, RB1, RET, TERT
23formaldehyde44 2410.6LGALS3, MKI67, RB1, CCND1
24adenylate449.6CCND1, CALCA, CASR, SCT, CGB5, PTH
25forskolin44 49 1111.5CALCA, CASR, SCT, CGB5, PTH, GSK3B
26tamoxifen44 49 28 1112.5CCND1, CGB5, MKI67, KRT14, PTH
27lysine449.4KRT14, MKI67, RB1, SCT, UCHL1, CASR
28estradiol44 11 2411.3CCND1, SCT, RB1, CGB5, MKI67, PTH
29thymidine44 2410.3CCND1, SCT, MEN1, RB1, MKI67, TERT
30doxorubicin44 49 1111.3CCND1, RB1, CGB5, MKI67, TERT
31glycogen44 2410.2CCND1, CGB5, MKI67, LGALS3, GSK3B
32oligonucleotide449.2CCND1, SCT, RB1, RET, TERT, LGALS3
33cysteine449.1CASR, UCHL1, SCT, RB1, RET, KRT14
34phosphatidylinositol449.1CCND1, CASR, SCT, RB1, RET, TERT
35genistein44 28 59 2 11 2414.1CCND1, RB1, CGB5, RET, TERT
36atp44 2810.1SCT, RB1, CGB5, RET, PTH, LGALS3
37cisplatin44 49 59 1112.1CCND1, RB1, CGB5, MKI67, KRT14, TERT
38cyclic amp44 2410.1CALCA, CASR, SCT, RB1, CGB5, RET
39progesterone44 59 28 11 2413.0CCND1, RB1, CGB5, MKI67, KRT14, LGALS3
40nitric oxide44 11 2410.9CALCA, CASR, RB1, CGB5, MKI67, TERT
41threonine448.9CCND1, RB1, MKI67, RET, KRT14, TERT
42paraffin448.8CCND1, RB1, CGB5, MKI67, RET, KRT14
43arginine448.7CASR, SCT, CGB5, MKI67, RET, KRT14
44retinoic acid44 249.6CCND1, SCT, RB1, CGB5, MKI67, RET
45lipid448.5SCT, RB1, CGB5, MKI67, RET, KRT14
46vegf448.5RB1, MEN1, CALCA, CCND1, CGB5, MKI67
47testosterone44 59 11 2411.4CCND1, CALCA, SCT, RB1, CGB5, MKI67
48calcium44 49 11 2411.1RB1, MEN1, SCT, CASR, CALCA, CGB5
49serine447.9MEN1, SCT, UCHL1, CASR, CCND1, RB1
50tyrosine447.7GSK3B, CCND1, CASR, UCHL1, SCT, MEN1

GO Terms for genes affiliated with Parathyroid Carcinoma

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16Gene Ontology
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Cellular components related to Parathyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:0057308.7MEN1, MKI67, RNF20, KRT14, TERT, GSK3B
2nucleusGO:0056347.2GSK3B, CCND1, CALCA, UCHL5, UCHL1, MEN1

Biological processes related to Parathyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1re-entry into mitotic cell cycleGO:00032010.2GSK3B, CCND1
2positive regulation of histone methylationGO:03106210.1RNF20, MEN1
3histone H2B ubiquitinationGO:03352310.0RNF20, CDC73
4histone monoubiquitinationGO:01039010.0RNF20, CDC73
5positive regulation of macrophage differentiationGO:0456519.9CALCA, RB1
6neuron maturationGO:0425519.7RB1, RET

Molecular functions related to Parathyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.9PTH, SCT, CALCA
2omega peptidase activityGO:0082429.6UCHL1, UCHL5
3protein bindingGO:0055156.8GSK3B, CCND1, CALCA, CASR, UCHL5, UCHL1

Products for genes affiliated with Parathyroid Carcinoma

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  • Antibodies
  • Proteins
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Sources for Parathyroid Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet