MCID: PRT010
MIFTS: 69

Parathyroid Carcinoma malady

Cancer diseases, Endocrine diseases categories

Summaries for Parathyroid Carcinoma

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Parathyroid carcinoma is a rare malignant neoplasm resulting in parathyroid adenoma to carcinoma... more...

MalaCards: Parathyroid Carcinoma, also known as parathyroid cancer, is related to hyperparathyroidism and parathyroid adenoma. An important gene associated with Parathyroid Carcinoma is CDC73 (cell division cycle 73), and among its related pathways are HTLV-I infection and Cell cycle. The compounds sb-216763 and pamidronate have been mentioned in the context of this disorder. Affiliated tissues include the parathyroid gl, thyroid and lung, and related mouse phenotypes are skeleton and respiratory system.

Disease Ontology:8 An endocrine gland cancer located in the parathyroid glands located in the neck.

Description from OMIM:46 608266

Aliases & Classifications for Parathyroid Carcinoma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 22GTR, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
parathyroid carcinoma:
Prevalence: 1-9/1000000


Aliases & Descriptions:

parathyroid carcinoma 8 9 42 46 10 44 48
parathyroid cancer 42 22 44
malignant tumor of parathyroid gland 8 60
malignant neoplasm of parathyroid gland 8
malignant neoplasm of the parathyroid 8
parathyroid gland adenocarcinoma 60
carcinoma of parathyroid gland 8
neoplasm of parathyroid gland 8
parathyroid gland neoplasm 8
parathyroid gland cancer 8
parathyroid neoplasms 60
parathyroid neoplasm 8


External Ids:

Disease Ontology8 DOID:1540
OMIM46 608266
NCIt39 C3313
MeSH34 D010282
ICD10 via Orphanet26 C75.0
SNOMED-CT via Orphanet57 255037004
ICD1025 C75.0

Related Diseases for Parathyroid Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Parathyroid Carcinoma family:

Cdc73-Related Parathyroid Carcinoma

Diseases related to Parathyroid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1hyperparathyroidism31.1CDC73, RET, SCT, CALCA, MEN1, PTH
2parathyroid adenoma30.9CCND1, CALCA, CASR, MEN1, CDC73, RET
3adenoma30.8PTH, CASR, CCND1, TERT, LGALS3, KRT14
4hypercalcemia30.8CALCA, PTH, CDC73, MEN1, SCT, CASR
5primary hyperparathyroidism30.8CALCA, CASR, SCT, MEN1, CDC73, RET
6thyroiditis30.5CALCA
7pancreatitis30.3SCT, CASR
8papillary thyroid carcinoma30.2LGALS3, CCND1, CALCA, RET, MEN1
9papillary carcinoma30.2RET, KRT14, LGALS3, MKI67, CALCA
10hyperparathyroidism-jaw tumor syndrome29.9CDC73
11osteitis fibrosa29.9PTH, CASR
12hypothyroidism29.9CASR, PTH
13neurofibromatosis29.9KRT14, RET, MEN1
14thyroid medullary carcinoma29.9MEN1, CASR, CALCA, RET, LGALS3
15thyroid cancer29.9TERT, CALCA, LGALS3, CASR, RET
16retinoblastoma29.9MKI67, KRT14, CCND1, RB1, TERT, MEN1
17mediastinitis10.5
18bone carcinoma10.5
19parathyroid cancer, childhood10.2
20acute pancreatitis10.1
21thymic carcinoma10.1
22cdc73-related parathyroid carcinoma10.1
23lung cancer10.0CCND1
24primary hyperoxaluria10.0CASR
25craniopharyngioma10.0KRT14
26multiple myeloma10.0CCND1
27giant cell tumor10.0CALCA
28sipple syndrome10.0B3GALT2
29wilms tumor10.0CDC73
30hirschsprung's disease10.0RET
31gastritis10.0SCT
32liver cirrhosis10.0SCT
33wermer syndrome10.0CDC73, MEN1
34hemangioma10.0RET, MEN1
35familial isolated hyperparathyroidism10.0CDC73, MEN1
36vipoma10.0SCT, MEN1
37prolactinoma10.0MEN1
38paget's disease of bone10.0CALCA
39leiomyosarcoma10.0RB1
40hypoparathyroidism familial isolated10.0CASR, PTH
41ductal carcinoma in situ10.0CCND1, KRT14
42glucagonoma10.0MEN1, SCT
43leukoplakia10.0MKI67
44calcinosis10.0PTH, CASR
45rhabdomyosarcoma10.0RB1
46deficiency anemia10.0PTH, CGB5
47insulin resistance10.0GSK3B
48chordoma10.0LGALS3, KRT14
49uremia10.0CASR, MEN1, PTH
50measles10.0SCT

Graphical network of the top 20 diseases related to Parathyroid Carcinoma:



Diseases related to parathyroid carcinoma

Clinical Features for Parathyroid Carcinoma

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46OMIM
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Clinical features from OMIM:

608266

Drugs & Therapeutics for Parathyroid Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Parathyroid Carcinoma

Drug clinical trials:

Search ClinicalTrials for Parathyroid Carcinoma

Search NIH Clinical Center for Parathyroid Carcinoma

Search CenterWatch for Parathyroid Carcinoma

Genetic Tests for Parathyroid Carcinoma

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22GTR
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Genetic tests related to Parathyroid Carcinoma:

id Genetic test Affiliating Genes
1 Parathyroid Carcinoma22

Anatomical Context for Parathyroid Carcinoma

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Parathyroid Carcinoma:

32
Thyroid, Lung, Bone, Breast, Liver, Prostate, Pituitary, Colon, Lymph node, Skin, Testes, Cervix, Monocytes, Endothelial, Ovary, Pancreas, Spinal cord, Brain, Thymus, Bone marrow

FMA organs/tissues related to Parathyroid Carcinoma:

14
The parathyroid gl

Animal Models for Parathyroid Carcinoma or affiliated genes

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36MGI
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Publications for Parathyroid Carcinoma

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50PubMed
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Articles related to Parathyroid Carcinoma:

(show top 50)    (show all 589)
idTitleAuthorsYear
1
Parathyroid carcinoma survival: improvements in the era of intact parathyroid hormone monitoring? (23772298)
2013
2
Complete genomic landscape of a recurring sporadic parathyroid carcinoma. (23616356)
2013
3
Ectopic mediastinal parathyroid carcinoma presenting as acute pancreatitis. (23351422)
2013
4
Novel HRPT2/CDC73 gene mutations and loss of expression of parafibromin in Chinese patients with clinically sporadic parathyroid carcinomas. (23029104)
2012
5
Hyperfunctional parathyroid carcinoma with mediastinal extension. (21296306)
2012
6
Parathyroid carcinoma. (23217487)
2012
7
Downregulation of CASR expression and global loss of parafibromin staining are strong negative determinants of prognosis in parathyroid carcinoma. (21240254)
2011
8
Parathyroid carcinoma in multiple endocrine neoplasia type 1. Case report and review of the literature. (22281890)
2011
9
Parathyroid carcinoma: current understanding and new insights into gene expression and intraoperative parathyroid hormone kinetics. (20051478)
2010
10
Nonfunctional parathyroid carcinoma. (20224881)
2010
11
Parathyroid carcinoma with anaplastic feature: association of a p53 gene mutation with anaplastic transformation. (19154265)
2009
12
Loss of heterozygosity of selected tumor suppressor genes in parathyroid carcinoma. (19041002)
2008
13
Mediastinal parathyroid carcinoma with tumor implants in a child: a unique occurrence. (18701514)
2008
14
An N-terminal molecular form of parathyroid hormone (PTH) distinct from hPTH(1 84) is overproduced in parathyroid carcinoma. (17599957)
2007
15
Parathyroid carcinoma in multiple endocrine neoplasia type 1 (MEN1) syndrome: two case reports of an unrecognised entity. (17392605)
2007
16
Subcutaneous local recurrence of parathyroid carcinoma. (17461325)
2006
17
Production of granulocyte colony-stimulating factor and parathyroid hormone-related protein in squamous cell carcinoma of the renal pelvis accompanied with inferior vena cava thrombus]. (17154030)
2006
18
Indian primary hyperparathyroidism patients with parathyroid carcinoma do not differ in clinicoinvestigative characteristics from those with benign parathyroid pathology. (16680588)
2006
19
Metastatic parathyroid carcinoma in the superior vena cava. (16213967)
2005
20
Expression of nm23 antimetastatic gene product in parathyroid hyperplasia, adenoma and carcinoma. An immunohistological assessment. (15951858)
2005
21
Proposal for the histological classification of parathyroid carcinoma. (16000846)
2005
22
Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma. (12864795)
2003
23
Primary hyperparathyroidism secondary to simultaneous bilateral parathyroid carcinoma. (12092283)
2002
24
Production of parathyroid hormone-related protein in two new cell lines of renal cell carcinoma. (11737483)
2001
25
Occult parathyroid carcinoma in a patient with papillary thyroid carcinoma and Hashimoto's thyroiditis. (11227731)
2001
26
Primary adenosquamous carcinoma of the liver which produces granulocyte-colony-stimulating factor and parathyroid hormone related protein: association with leukocytosis and hypercalcemia. (11506305)
2001
27
Multiple brown tumors simulating bone metastases: a case of parathyroid adenoma coexisting with papillary carcinoma of the thyroid. (11043714)
2000
28
Induction of cellular immunity in a parathyroid carcinoma treated with tumor lysate-pulsed dendritic cells. (10700726)
2000
29
Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995: a National Cancer Data Base Report. The American College of Surgeons Commission on Cancer and the American Cancer Society. (10430265)
1999
30
Malignant hypercalcemia induced by a parathyroid hormone-related protein secreted by a cutaneous squamous cell carcinoma. (9006391)
1997
31
Parathyroid carcinoma and primary autoimmune hypothyroidism in an elderly woman. (9125488)
1997
32
Clonal heterogeneity of the growth and invasive response of a human breast carcinoma cell line to parathyroid hormone-related peptide fragments. (9054585)
1997
33
Thyroid anaplastic carcinoma producing granulocyte-colony-stimulating factor and parathyroid hormone-related protein. (7549149)
1995
34
Patterns of DNA methylation of the parathyroid hormone-related protein gene in human lung carcinoma. (7488427)
1995
35
In situ localization of parathyroid hormone-like protein and mRNA in intraepithelial neoplasia and invasive carcinoma of the uterine cervix. (8406415)
1993
36
Hypercalcemia and parathyroid hormone-related protein in hepatocellular carcinoma. (8295494)
1993
37
Humoral hypercalcaemia in renal carcinoma due to parathyroid hormone related protein. (8306145)
1993
38
Parathyroid hormone-related protein, chromogranin A, and calcitonin gene products in the neuroendocrine skin carcinoma cell lines MKL1 and MKL2. (1717086)
1991
39
Parathyroid carcinoma: a review. (3309302)
1987
40
Nonsecretory parathyroid carcinoma of the mediastinum. Light microscopic, immunocytochemical, and ultrastructural features of a case, and review of the literature. (3533247)
1986
41
Natural history of parathyroid carcinoma. Diagnosis, treatment, and results. (3985291)
1985
42
Parathyroid carcinoma presenting as tertiary hyperparathyroidism. (3983057)
1985
43
Fatal acute hyperparathyroidism and parathyroid carcinoma. (6828913)
1983
44
Parathyroid carcinoma in an adolescent. (522827)
1979
45
Successful removal of single metastasis in recurrent parathyroid carcinoma. (4691063)
1973
46
Recurrent hyperparathyroidism due to parathyroid carcinoma. (4107487)
1971
47
Parathyroid carcinoma. (13483715)
1957
48
Mediastinal parathyroid carcinoma with metastases; report of a case and review of the literature. (13420393)
1957
49
Metastasizing Carcinoma of the Parathyroid Gland with Osteitis Fibrosa Cystica and Extensive Calcinosis. (19970978)
1951
50
Parathyroid carcinoma. (14897475)
1951

Genetic Variations for Parathyroid Carcinoma

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Expression for genes affiliated with Parathyroid Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Parathyroid Carcinoma

Search GEO for disease gene expression data for Parathyroid Carcinoma.

Pathways for genes affiliated with Parathyroid Carcinoma

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology
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Compounds for genes affiliated with Parathyroid Carcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Parathyroid Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1sb-2167634410.3CCND1, GSK3B
2pamidronate44 49 1112.3CALCA, CASR, PTH
3depsipeptide4410.3CCND1
4gossypol4410.1RB1, CCND1, CGB5
51,25 dihydroxy vitamin d34410.0CASR, CALCA, PTH, RB1
625-hydroxyvitamin d4410.0CALCA, CASR, PTH
7acetone449.9MKI67, CGB5, CCND1
8vincristine44 49 1111.9MKI67, RB1, CALCA, CCND1
9calcitriol44 59 11 2412.8CASR, CALCA, PTH, TERT, RB1
10ibmx44 28 5911.8CALCA, PTH, CGB5, SCT
11streptavidin449.8CGB5, MKI67, SCT
12paclitaxel44 49 1111.8TERT, CCND1, RB1, CGB5
13dutp449.8LGALS3, MKI67, CCND1
14vitamin d449.8MEN1, PTH, CASR, CALCA, LGALS3, KRT14
15thymidylate449.7CCND1, MKI67, RB1, TERT
16acth449.7CALCA, CASR, CGB5, SCT, LGALS3
17bromodeoxyuridine449.7MKI67, RB1, CCND1, KRT14, PTH
18ribonucleic acid449.6RET, CGB5, TERT, PTH, CASR
19wortmannin449.6CCND1, RET, TERT, LGALS3, CASR
20phosphorus449.6PTH, CALCA, CASR
21glucose449.6SCT, CASR, CGB5, KRT14, PTH
22pd 98,059449.6CASR, SCT, RB1, RET, TERT, CCND1
23formaldehyde44 2410.6MKI67, RB1, LGALS3, CCND1
24adenylate449.6PTH, CGB5, SCT, CASR, CALCA, CCND1
25forskolin44 49 1111.5GSK3B, CGB5, CASR, CALCA, SCT, PTH
26tamoxifen44 49 28 1112.5KRT14, MKI67, CGB5, CCND1, PTH
27lysine449.4UCHL1, RB1, MKI67, KRT14, CASR, SCT
28estradiol44 11 2411.3SCT, RB1, MKI67, PTH, CCND1, CGB5
29thymidine44 2410.3PTH, RB1, TERT, MKI67, MEN1, SCT
30doxorubicin44 49 1111.3RB1, MKI67, CGB5, TERT, CCND1
31glycogen44 2410.2CGB5, CCND1, MKI67, GSK3B, LGALS3
32oligonucleotide449.2TERT, RET, RB1, SCT, LGALS3, CCND1
33cysteine449.1TERT, SCT, KRT14, UCHL1, LGALS3, CASR
34phosphatidylinositol449.1GSK3B, CCND1, SCT, RB1, CASR, RET
35genistein44 28 59 2 11 2414.1TERT, RET, CGB5, RB1, CCND1
36atp44 2810.1RB1, CGB5, RET, LGALS3, SCT, PTH
37cisplatin44 49 59 1112.1LGALS3, TERT, CCND1, RB1, CGB5, MKI67
38cyclic amp44 2410.1CASR, CGB5, SCT, GSK3B, RB1, PTH
39progesterone44 59 28 11 2413.0CGB5, LGALS3, KRT14, MKI67, RB1, CCND1
40nitric oxide44 11 2410.9PTH, MKI67, RB1, LGALS3, CGB5, TERT
41threonine448.9GSK3B, KRT14, RET, MKI67, RB1, TERT
42paraffin448.8CCND1, LGALS3, TERT, KRT14, RET, MKI67
43arginine448.7TERT, LGALS3, KRT14, RET, MKI67, SCT
44retinoic acid44 249.6LGALS3, MKI67, TERT, KRT14, RET, CGB5
45lipid448.5LGALS3, TERT, KRT14, RET, MKI67, GSK3B
46vegf448.5MEN1, CGB5, CCND1, CALCA, RB1, MKI67
47testosterone44 59 11 2411.4CCND1, CALCA, SCT, RB1, CGB5, MKI67
48calcium44 49 11 2411.1CASR, RB1, CGB5, PTH, TERT, SCT
49serine447.9RET, LGALS3, TERT, KRT14, GSK3B, MKI67
50tyrosine447.7TERT, KRT14, CCND1, CASR, UCHL1, SCT

GO Terms for genes affiliated with Parathyroid Carcinoma

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16Gene Ontology
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Cellular components related to Parathyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:0057308.7MEN1, MKI67, RNF20, KRT14, TERT, GSK3B
2nucleusGO:0056347.2GSK3B, CCND1, CALCA, UCHL5, UCHL1, MEN1

Biological processes related to Parathyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1re-entry into mitotic cell cycleGO:00032010.2GSK3B, CCND1
2positive regulation of histone methylationGO:03106210.1RNF20, MEN1
3histone H2B ubiquitinationGO:03352310.0RNF20, CDC73
4histone monoubiquitinationGO:01039010.0RNF20, CDC73
5positive regulation of macrophage differentiationGO:0456519.9CALCA, RB1
6neuron maturationGO:0425519.7RB1, RET

Molecular functions related to Parathyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.9PTH, SCT, CALCA
2omega peptidase activityGO:0082429.6UCHL1, UCHL5
3protein bindingGO:0055156.8GSK3B, CCND1, CALCA, CASR, UCHL5, UCHL1

Products for genes affiliated with Parathyroid Carcinoma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Parathyroid Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet