MCID: PRT002
MIFTS: 55

Paratyphoid Fever malady

Infectious category

Summaries for Paratyphoid Fever

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A primary bacterial infectious disease that results in infection located in intestine, has material basis in salmonella enterica subsp enterica serovar paratyphi a, b or c, which are transmitted by ingestion of contaminated food. the infection has symptom fever, has symptom headache, has symptom abdominal pain, has symptom malaise, has symptom anorexia, has symptom constipation, has symptom rosy spots on the central body, has symptom non productive cough (in early stage of illness), has symptom bradycardia, and has symptom hepatosplenomegaly.

MalaCards: Paratyphoid Fever, also known as paratyphoid b fever, is related to typhoid fever and appendicitis, and has symptoms including fever, headache and abdominal pain. An important gene associated with Paratyphoid Fever is IFNGR1 (interferon gamma receptor 1), and among its related pathways are Th17 Differentiation and Senescence and Autophagy. The compounds amphotericin b and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include intestine, bone marrow and whole blood, and related mouse phenotypes are integument and tumorigenesis.

Wikipedia:64 Paratyphoid fevers are a group of enteric illnesses caused by serotypic strains of the Salmonella genus... more...

Aliases & Classifications for Paratyphoid Fever

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

paratyphoid fever 8 10 61
paratyphoid b fever 8 61
paratyphoid c fever 8 61
paratyphoid fever a 8
paratyphoid a fever 8
paratyphoid fever c 8
paratyphoid fever b 8
paratyphoid b 8
paratyphoid a 8
paratyphoid c 8
paratyphoid 8


Related Diseases for Paratyphoid Fever

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Paratyphoid Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1typhoid fever31.5IFNGR1, HIST1H1D
2appendicitis30.2CRP
3vasculitis30.2CRP
4aortic aneurysm29.9CRP
5q fever10.3
6biliary atresia10.1
7n syndrome10.1
8urticaria10.0CASP1
9diabetic retinopathy10.0CASP1
10hodgkin's lymphoma10.0HDAC11
11campylobacteriosis10.0SUMF2
12neutropenia10.0TNFRSF1A
13schnitzler syndrome10.0IL1R1
14common variable immune deficiency10.0TNFRSF1A
15down syndrome10.0CASP1
16infertility10.0CASP1
17hepatocellular carcinoma10.0CASP1
18pancreatic cancer10.0CASP1
19measles10.0IL12B, HIST1H1A
20polymyalgia rheumatica10.0CRP
21paracoccidioidomycosis10.0TNFRSF1A
22dermatomyositis10.0IL1A
23silicosis10.0IL1A
24crohn's disease10.0CRP
25rheumatic disease10.0CRP
26pemphigus vulgaris10.0IL1A
27ulcerative colitis10.0CRP
28deficiency anemia10.0CRP
29viral hepatitis10.0TNFRSF1A
30rheumatic fever10.0CRP
31mycobacterium avium complex disease10.0IFNGR1
32myeloid leukemia10.0CASP1
33acute myocardial infarction10.0CRP
34hypercalcemia10.0IL1A
35hyperglycemia10.0CRP
36insulinoma10.0CASP1
37herpes simplex10.0CASP1, IL12B
38kawasaki disease10.0CRP
39pulmonary fibrosis10.0IL1B
40systemic lupus erythematosus10.0CRP
41polymyositis10.0IL1A
42interstitial lung disease10.0IL1B
43coronary heart disease10.0CRP
44obesity10.0CRP
45acquired immunodeficiency syndrome10.0IL1B
46septic arthritis10.0CRP
47acute pyelonephritis10.0CRP
48degenerative disc disease10.0IL1B
49amyotrophic lateral sclerosis10.0CASP1
50myopathy10.0CRP

Graphical network of the top 20 diseases related to Paratyphoid Fever:



Diseases related to paratyphoid fever

Clinical Features for Paratyphoid Fever

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 10)
  • fever
  • headache
  • abdominal pain
  • malaise
  • anorexia
  • constipation
  • rosy spots on the central body
  • non productive cough (in early stage of illness)
  • bradycardia
  • hepatosplenomegaly

Drugs & Therapeutics for Paratyphoid Fever

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Paratyphoid Fever

Drug clinical trials:

Search ClinicalTrials for Paratyphoid Fever

Search NIH Clinical Center for Paratyphoid Fever

Search CenterWatch for Paratyphoid Fever

Genetic Tests for Paratyphoid Fever

Anatomical Context for Paratyphoid Fever

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Paratyphoid Fever:

33
Bone marrow, Whole blood

FMA organs/tissues related to Paratyphoid Fever:

14
Intestine

Animal Models for Paratyphoid Fever or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Paratyphoid Fever

Sources:
51PubMed
See all sources

Articles related to Paratyphoid Fever:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
Correction: The Application of the Grey Disaster Model to Forecast Epidemic Peaks of Typhoid and Paratyphoid Fever in China. (24039655)
2013
2
Spatiotemporal transmission and determinants of typhoid and paratyphoid fever in Hongta District, Yunnan Province, China. (23516653)
2013
3
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (21975746)
2011
4
Typhoid and paratyphoid fever - prevention in travellers. (21301658)
2010
5
Global trends in typhoid and paratyphoid Fever. (20014951)
2010
6
Epidemiology of typhoid and paratyphoid fever in India. (19745523)
2008
7
Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever. (17477815)
2007
8
Ty21a live oral typhoid vaccine and prevention of paratyphoid fever caused by Salmonella enterica Serovar Paratyphi B. (17582564)
2007
9
Typhoid and paratyphoid fever. (16125594)
2005
10
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (15846718)
2005
11
Typhoid and paratyphoid fever in travellers. (16183516)
2005
12
Epidemiology of typhoid and paratyphoid fever in Kathmandu: two years study and trends of antimicrobial resistance. (16082406)
2005
13
Risk factors for typhoid and paratyphoid fever in Jakarta, Indonesia. (15173152)
2004
14
LipschA1tz genital ulceration: a rare manifestation of paratyphoid fever. (12804994)
2003
15
Paratyphoid fever in India: An emerging problem. (10341194)
1999
16
Monoclonal antibodies against protein antigens of salmonellae causing paratyphoid fever and their diagnostic application. (7488347)
1995
17
Paratyphoid fever: analysis of 18 cases and its unusual complications. (3146430)
1988
18
Paratyphoid fever presenting with grand mal fits and cerebellar signs. (3920327)
1985
19
Cutaneous leukocytoclastic vasculitis in the rose spot of paratyphoid fever. (6807856)
1982
20
Paratyphoid fever: a report of 62 cases with several unusual findings and a review of the literature. (826229)
1976
21
A case of paratyphoid fever accidentally treated with amoxycillin. (Case report). (4218307)
1974
22
Haemoglobinuria due to typhoid and paratyphoid fever. (4621889)
1972
23
Unusual case of paratyphoid fever. (4625730)
1972
24
Influence of chloramphenicol and ampicillin on antibody response in typhoid-paratyphoid fever. (4984110)
1970
25
Treatment of typhoid and paratyphoid fever with nalidixic acid. (4987433)
1970
26
Epidemiological investigations of typhoid and paratyphoid fever in Japan with aid of the phage typing method. I. Distribution of phage-types of salmonella typhi and salmonella paratyphi b in Japan, 1956-1965. (4968085)
1967
27
AMPICILLIN IN PARATYPHOID FEVER. (14072629)
1964
28
Transport in the tropics of faecal samples for bacteriological examination for typhoid and paratyphoid fever and bacillary dysentery. (13753960)
1960
29
Acute ileitis with ulceration and perforation due to paratyphoid fever; report of eighty-five cases. (13399825)
1957
30
Typhoid and paratyphoid fever; report of six cases with one death. (13361260)
1956
31
Second attack of paratyphoid fever. (13276681)
1956
32
Some Important Lessons from the Lancaster, Pennsylvania, Paratyphoid Fever Epidemic. (18017556)
1956
33
Paratyphoid fever associated with Chinese frozen whole egg; outbreaks in two bakeries. (13269854)
1955
34
PARATYPHOID fever and cream cakes. (13094092)
1953
35
Two cases of paratyphoid fever treated with chloramphenicol. (14772491)
1950
36
Typhoid and paratyphoid fever; a review of four cases treated with chloromycetin. (15405410)
1950
37
A difficulty experienced in the bacteriological diagnosis of paratyphoid fever in cases treated with sulphonamides. (18130255)
1949
38
Field investigation of paratyphoid fever with typing of Salm. paratyphi B by means of Vi bacteriophage. (20262099)
1947
39
Paratyphoid fever. (20296482)
1946
40
3 cases of skeletal changes round the knee joint in paratyphoid fever in infants. (20985426)
1946
41
Paratyphoid fever simulating acute appendicitis. (20275908)
1946
42
Paratyphoid fever: an epidemiological study. (20475641)
1942
43
Paratyphoid Fever and Aertrycke Enteritis in Aberdeen-a Contrast. (20474903)
1926
44
DISCUSSION ON PARATYPHOID FEVER. (19979278)
1916
45
COMBINED PREVENTIVE INOCULATION AGAINST TYPHOID AND PARATYPHOID FEVER AND BACILLARY DYSENTERY. (20767977)
1916
46
Discussion on Paratyphoid Fever. (19979284)
1916
47
Discussion on Paratyphoid Fever. (19979282)
1916
48
Report of an Epidemic of Probable Paratyphoid Fever. (19599427)
1910
49
Observations on the Bacteriology of Paratyphoid Fever and on the Reactions of Typhoid and Paratyphoid Sera. (20474245)
1906
50
A Note on Paratyphoid Fever from the Public Health Standpoint. (19599793)
1903

Genetic Variations for Paratyphoid Fever

Expression for genes affiliated with Paratyphoid Fever

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Paratyphoid Fever

Search GEO for disease gene expression data for Paratyphoid Fever.

Pathways for genes affiliated with Paratyphoid Fever

Sources:
53R&D Systems, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 30KEGG, 52QIAGEN, 60Tocris Bioscience
See all sources

Pathways related to Paratyphoid Fever according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3IL1R1
210.1CXCL14
310.1IFNGR1, IFNG
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.0IFNG, IL1A
5
Hide members
9.9IL1A, IL12B, IFNGR1
6
Apoptosis and survival Caspase cascade
Hide members
9.9CASP1, TNFRSF1A, IL1A
79.9IL1B, IL12B, CASP1
89.9TNFRSF1A, IL1R1, IL1A
9
Hide members
9.9IFNG, IFNGR1, TNFRSF1A
109.9IL1B, IL1R1, TNFRSF1A
119.8IL1B, IL1A, CASP1
12
Hide members
9.8IL1B, IL1A, IL1R1
13
Hide members
9.8IL1B, IL1A, IL1R1
149.8IL1R1, IL1A, IL1B
159.8IL1R1, IL1A, IL1B
16
Hide members
9.8OGN, TNFRSF1A, IL12B
179.8IL1B, IFNGR1, IFNG
189.8IFNG, IL12B, IL1B
199.8IL1B, IL12B, IFNG
209.8IFNG, CRP, IL1B
219.7IL1B, IL1A, IL12B, CASP1
22
Hide members
9.6CASP1, IL1R1, IL1A, IL1B
23
Hide members
9.6CASP1, IL1R1, IL1A, IL1B
24
Hide members
9.6OGN, CXCL14, IL12B
25
Hide members
9.6IL1B, IL12B, IFNGR1, IFNG
26
Immune response IFN gamma signaling pathway
Hide members
9.6CASP1, IFNG, IFNGR1, IL1B
279.6IL1B, IL1R1, IL12B, IFNG
28
Hide members
9.6IFNG, IL12B, IL1R1, IL1B
299.6IL1B, IL1A, IL12B, IFNG
309.6IFNG, IL12B, IL1A, IL1B
31
Hide members
9.5IL1B, IL1A, IL1R1, TNFRSF1A, CASP1
32
Hide members
9.5CASP1, TNFRSF1A, IL1R1, IL1A, IL1B
33
Hide members
9.4IL1B, IL12B, TNFRSF1A, IFNGR1, IFNG
349.4CASP1, IFNG, IFNGR1, IL1A, IL1B
35
Immune response Bacterial infections in normal airways
Hide members
9.4IFNG, IFNGR1, IL1R1, IL1A, IL1B
36
Hide members
9.4IL1B, IL1A, IL1R1, IFNGR1, IFNG
37
Hide members
9.4OGN, TNFRSF1A, IL1R1, IL1A, IL1B
38
Hide members
9.3CASP1, TNFRSF1A, IL12B, IL1R1, IL1A, IL1B
39
Hide members
9.3OGN, TNFRSF1A, CXCL14, IL12B, IL1R1
40
Hide members
9.2CASP1, IFNG, IFNGR1, IL1R1, IL1A, IL1B
41
Hide members
9.2CASP1, IFNG, TNFRSF1A, HIST1H1A, HIST1H1D
429.2IFNG, IFNGR1, TNFRSF1A, IL12B, IL1A, IL1B
43
Hide members
9.2IFNG, IFNGR1, TNFRSF1A, IL12B, IL1A, IL1B
449.2IFNG, IFNGR1, TNFRSF1A, IL1R1, IL1A, IL1B
45
Hide members
9.2IFNG, IFNGR1, TNFRSF1A, IL1R1, IL1A, IL1B
46
Hide members
9.0CASP1, IFNG, IFNGR1, TNFRSF1A, IL12B, IL1A
47
Hide members
9.0CASP1, IFNG, IFNGR1, CTSC, IL1R1, IL1A
48
Hide members
8.9IL1A, CXCL14, HDAC11, TNFRSF1A, IFNGR1, CASP1
49
Hide members
8.8OGN, TNFRSF1A, CXCL14, IL12B, IL1R1, IL1A

Compounds for genes affiliated with Paratyphoid Fever

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Paratyphoid Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1amphotericin b4510.6IL1R1
2indomethacin45 60 29 1113.6IL1R1
3endotoxin4510.6CASP1, TNFRSF1A
4tenidap45 2911.5IL1R1, IL1A
5pirfenidone45 6011.4IL1B, IL1A
6pentoxifylline45 1111.4IL12B, IL1R1, CASP1
7gm-csf45 2911.3IFNG
8acetyl-tyr-val-ala-asp-cho4510.3CASP1, IL1B
9nh4cl4510.3CTSC, TNFRSF1A
10git 276010.2IL1A, IL1B, IL1R1
114-ipp6010.2IL1B, IL1A, IL1R1
12bucillamine4510.1CRP, IL1B, IFNG
13minocycline45 1111.1IL1A, CASP1, IL1B
14adalimumab45 50 1112.1IL1R1, IFNG, CRP
15auranofin45 60 29 1113.1IFNG, IL1A, IL1B
16imiquimod45 29 60 1113.1IL12B, IFNG, IL1A
17peptidoglycan45 2911.1IL1R1, CASP1, IL12B, IL1B
18staurosporin4510.1CASP1, IL1B, IFNG
19cuprophan4510.1CASP1, IL1R1, IL1B, TNFRSF1A
20anakinra45 1111.1IL1B, IL1R1, CRP, CASP1
21as 10160 4511.1IL1A, IL1R1, CASP1, IL1B
22polysulfone4510.1IL1B, IL1R1, CRP
23il-124510.0IL1B, IFNG, IL1R1, IL12B
24poly(i-c)4510.0IL12B, IL1B, IFNG, CASP1
25leflunomide50 45 1112.0TNFRSF1A, IL1B, IL1R1
26gold sodium thiomalate4510.0IFNG, IL1R1, IL1A, IL1B
27polyethylene glycol4510.0IL1R1, CRP, TNFRSF1A, IL1A
28polyinosinic-polycytidylic acid4510.0IFNG, IL1B, IL1A, IL12B
29okt34510.0IFNG, TNFRSF1A, CRP
30polymyxin b4510.0IL1A, IFNG, IL1B
31ccl345 2911.0IL1R1, IL1B, IL1A, IFNG
32lipoteichoic acid459.9IL1B, IL1R1, IL12B
33sulfasalazine45 29 50 1112.9IL1A, IL1R1, IL12B, CRP, IL1B
34il 10459.8IL12B, IL1B, IL1A, IL1R1, IFNG
35ns 39845 6010.8IL1B, IL1A, TNFRSF1A
36etanercept45 50 1111.8IL1B, CRP, TNFRSF1A, IFNG, IL1R1
37infliximab45 50 1111.8IL1B, IL1R1, CRP, IFNG, TNFRSF1A
38thalidomide45 50 60 1112.8IL1A, IL1B, IL1R1, TNFRSF1A, IFNG
39ribonucleic acid459.8IL1R1, IL1B, IL1A, TNFRSF1A, CASP1
40n acetylcysteine459.8TNFRSF1A, CRP, IL1R1, CASP1, IL1B
41rantes459.6IL1A, IL1B, IFNG, TNFRSF1A, IL12B, IL1R1
42ivig459.6IL1R1, CRP, TNFRSF1A, IFNG, IL1A, IL1B
43neopterin459.6IFNG, CRP, IL1R1, TNFRSF1A, IL1B, IL1A
44actinomycin d459.6IFNG, CASP1, TNFRSF1A, IL1B, IL1A, IL1R1
45simvastatin45 50 60 29 11 2414.6TNFRSF1A, IL1A, IFNG, CRP
46s-nitroso-n-acetylpenicillamine459.5IL1B, CASP1, IFNG
47herbimycin a45 6010.5IL1A, IL1B, TNFRSF1A, IFNG
48nitric oxide45 11 2411.4CASP1, TNFRSF1A, IL12B, IL1R1, IL1A, IFNG
49vegf459.3IFNG, IL1B, CASP1, TNFRSF1A, CRP, IL1R1
50sb 20358045 6010.2TNFRSF1A, IFNG, CRP, IL12B, IL1R1, IL1A

GO Terms for genes affiliated with Paratyphoid Fever

Sources:
16Gene Ontology
See all sources

Cellular components related to Paratyphoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.7CASP1, OGN, IFNG, TNFRSF1A, CRP, IL1R1
2extracellular spaceGO:0056158.2OGN, IFNG, TNFRSF1A, CRP, CXCL14, IL12B

Biological processes related to Paratyphoid Fever according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1interleukin-1 beta productionGO:03261110.3CASP1, IL1B
2fever generationGO:00166010.3IL1B, IL1A
3positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.3IL12B, IL1B
4positive regulation of calcidiol 1-monooxygenase activityGO:06055910.3IFNG, IL1B
5positive regulation of smooth muscle cell apoptotic processGO:03439310.3IL12B, IFNG
6negative regulation of interleukin-17 productionGO:03270010.2IFNG, IL12B
7positive regulation of interleukin-6 biosynthetic processGO:04541010.2IL1B, IFNG
8positive regulation of tumor necrosis factor productionGO:03276010.2IL12B, TNFRSF1A, IFNG
9positive regulation of chemokine biosynthetic processGO:04508010.2IFNG, IL1B
10positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.1TNFRSF1A, IFNG
11cellular response to mechanical stimulusGO:07126010.1IL1B, TNFRSF1A, CASP1
12negative regulation of smooth muscle cell proliferationGO:04866210.1OGN, IFNG, IL12B
13positive regulation of T cell proliferationGO:04210210.1IL1B, IL12B, IFNG
14positive regulation of interleukin-2 biosynthetic processGO:04508610.0IL1B, IL1A
15positive regulation of angiogenesisGO:0457669.9TNFRSF1A, IL1A, IL1B
16positive regulation of membrane protein ectodomain proteolysisGO:0510449.9IL1B, IFNG
17cytokine-mediated signaling pathwayGO:0192219.7IL1B, IL1A, TNFRSF1A, IFNGR1, IFNG
18immune responseGO:0069559.5IL1B, IL1A, IL1R1, CXCL14, CTSC
19apoptotic processGO:0069159.4IL1B, IL1A, TNFRSF1A, IFNG, CASP1
20inflammatory responseGO:0069549.3TNFRSF1A, CRP, IL1A, IL1B

Molecular functions related to Paratyphoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.0IL1B, IL1A
2cytokine activityGO:0051259.3IL1B, IL1A, IL12B, IFNG

Products for genes affiliated with Paratyphoid Fever

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Paratyphoid Fever

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet