MCID: PRT002
MIFTS: 62

Paratyphoid Fever malady

Infectious diseases category

Summaries for Paratyphoid Fever

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection located in intestine, has material basis in salmonella enterica subsp enterica serovar paratyphi a, b or c, which are transmitted by ingestion of contaminated food. the infection has symptom fever, has symptom headache, has symptom abdominal pain, has symptom malaise, has symptom anorexia, has symptom constipation, has symptom rosy spots on the central body, has symptom non productive cough (in early stage of illness), has symptom bradycardia, and has symptom hepatosplenomegaly.

MalaCards: Paratyphoid Fever, also known as paratyphoid b fever, is related to typhoid fever and appendicitis, and has symptoms including hepatosplenomegaly, bradycardia and non productive cough (in early stage of illness). An important gene associated with Paratyphoid Fever is IFNGR1 (interferon gamma receptor 1), and among its related pathways are Th17 Differentiation and Senescence and Autophagy. The compounds amphotericin b and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include intestine, testes and bone, and related mouse phenotypes are integument and tumorigenesis.

Wikipedia:63 Paratyphoid fevers are a group of enteric illnesses caused by serotypic strains of the Salmonella genus... more...

Aliases & Classifications for Paratyphoid Fever

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

paratyphoid fever 8 10 60
paratyphoid b fever 8 60
paratyphoid c fever 8 60
paratyphoid fever a 8
paratyphoid a fever 8
paratyphoid fever c 8
paratyphoid fever b 8
paratyphoid b 8
paratyphoid a 8
paratyphoid c 8
paratyphoid 8


Related Diseases for Paratyphoid Fever

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17GeneCards, 18GeneDecks
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Diseases related to Paratyphoid Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1typhoid fever31.5IFNGR1, HIST1H1D
2appendicitis30.1CRP
3vasculitis30.1CRP
4aortic aneurysm29.9CRP
5rare form of salmonellosis10.6
6dysentery10.3
7relapsing fever10.3
8biliary atresia10.1
9duodenitis10.1
10nephrotic syndrome10.1
11purpura10.1
12spotted fever10.1
13urticaria10.0CASP1
14diabetic retinopathy10.0CASP1
15hodgkin's lymphoma10.0HDAC11
16campylobacteriosis10.0SUMF2
17neutropenia10.0TNFRSF1A
18schnitzler syndrome10.0IL1R1
19common variable immune deficiency10.0TNFRSF1A
20down syndrome10.0CASP1
21infertility10.0CASP1
22hepatocellular carcinoma10.0CASP1
23pancreatic cancer10.0CASP1
24measles10.0IL12B, HIST1H1A
25polymyalgia rheumatica10.0CRP
26paracoccidioidomycosis10.0TNFRSF1A
27dermatomyositis10.0IL1A
28silicosis10.0IL1A
29crohn's disease10.0CRP
30rheumatic disease10.0CRP
31pemphigus vulgaris10.0IL1A
32ulcerative colitis10.0CRP
33deficiency anemia10.0CRP
34viral hepatitis10.0TNFRSF1A
35rheumatic fever10.0CRP
36mycobacterium avium complex disease10.0IFNGR1
37myeloid leukemia10.0CASP1
38acute myocardial infarction10.0CRP
39hypercalcemia10.0IL1A
40hyperglycemia10.0CRP
41insulinoma10.0CASP1
42herpes simplex10.0CASP1, IL12B
43kawasaki disease10.0CRP
44pulmonary fibrosis10.0IL1B
45systemic lupus erythematosus10.0CRP
46polymyositis10.0IL1A
47interstitial lung disease10.0IL1B
48coronary heart disease10.0CRP
49obesity10.0CRP
50acquired immunodeficiency syndrome10.0IL1B

Graphical network of the top 20 diseases related to Paratyphoid Fever:



Diseases related to paratyphoid fever

Clinical Features for Paratyphoid Fever

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8Disease Ontology
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Symptoms:

8 (show all 10)
  • hepatosplenomegaly
  • bradycardia
  • non productive cough (in early stage of illness)
  • rosy spots on the central body
  • constipation
  • anorexia
  • malaise
  • abdominal pain
  • headache
  • fever

Drugs & Therapeutics for Paratyphoid Fever

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Paratyphoid Fever

Search NIH Clinical Center for Paratyphoid Fever

Search CenterWatch for Paratyphoid Fever

Genetic Tests for Paratyphoid Fever

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Anatomical Context for Paratyphoid Fever

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Paratyphoid Fever:

32
Testes, Bone, Bone marrow

FMA organs/tissues related to Paratyphoid Fever:

14
Intestine

Animal Models for Paratyphoid Fever or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Paratyphoid Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.3CASP1, OGN, CTSC, IL1R1
2MP:00020069.2CASP1, IFNG, IFNGR1, TNFRSF1A, IL12B, IL1R1
3MP:00053679.1IL1R1, CXCL14, TNFRSF1A, IFNGR1, IFNG, CASP1
4MP:00053858.5CASP1, IFNG, IFNGR1, TNFRSF1A, CRP, HIST1H1D
5MP:00053978.3CASP1, IFNG, IFNGR1, TNFRSF1A, HIST1H1D, CXCL14
6MP:00053877.9IL1B, CASP1, IFNG, IFNGR1, TNFRSF1A, CTSC
7MP:00053767.8CASP1, OGN, IFNG, IFNGR1, TNFRSF1A, CTSC

Publications for Paratyphoid Fever

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50PubMed
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Articles related to Paratyphoid Fever:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
Correction: The Application of the Grey Disaster Model to Forecast Epidemic Peaks of Typhoid and Paratyphoid Fever in China. (24039655)
2013
2
The application of the grey disaster model to forecast epidemic peaks of typhoid and paratyphoid fever in China. (23565260)
2013
3
Spatiotemporal transmission and determinants of typhoid and paratyphoid fever in Hongta District, Yunnan Province, China. (23516653)
2013
4
Typhoid and paratyphoid fever in Western Sydney Local Health District, NSW, January-June 2011. (23043747)
2012
5
Typhoid fever and paratyphoid fever: Systematic review to estimate global morbidity and mortality for 2010. (23198130)
2012
6
Burden of typhoid and paratyphoid fever in a densely populated urban community, Dhaka, Bangladesh. (20236850)
2010
7
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (18843659)
2008
8
Epidemiology of typhoid and paratyphoid fever in India. (19745523)
2008
9
Comparisons of predictors for typhoid and paratyphoid fever in Kolkata, India. (17935611)
2007
10
Deep-seated resistance in relapsed paratyphoid fever. (16652303)
2006
11
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (15846718)
2005
12
Typhoid and paratyphoid fever in travellers. (16183516)
2005
13
Identification of typhoid fever and paratyphoid fever cases at presentation in outpatient clinics in Jakarta, Indonesia. (15837356)
2005
14
Typhoid and paratyphoid fever. (16271635)
2005
15
Risk factors for typhoid and paratyphoid fever in Jakarta, Indonesia. (15173152)
2004
16
An unusual paratyphoid fever. (11762624)
2001
17
Epidemiological studies of an outbreak of paratyphoid fever in the Shima area of Mie Prefecture. (10738368)
1999
18
Monoclonal antibodies against protein antigens of salmonellae causing paratyphoid fever and their diagnostic application. (7488347)
1995
19
An outbreak of paratyphoid fever in the UK associated with a fish-and-chip shop. (2514109)
1989
20
Cutaneous leukocytoclastic vasculitis in the rose spot of paratyphoid fever. (6807856)
1982
21
Paratyphoid fever: a report of 62 cases with several unusual findings and a review of the literature. (826229)
1976
22
A case of paratyphoid fever accidentally treated with amoxycillin. (Case report). (4218307)
1974
23
Haemoglobinuria due to typhoid and paratyphoid fever. (4621889)
1972
24
Unusual case of paratyphoid fever. (4625730)
1972
25
Typhoid and paratyphoid fever in children. Review of symptoms and therapy in 165 cases. (4975732)
1969
26
AMPICILLIN IN PARATYPHOID FEVER. (14072629)
1964
27
Paratyphoid fever traced to desiccated coconut. (13750036)
1961
28
Typhoid and paratyphoid fever; report of six cases with one death. (13361260)
1956
29
Paratyphoid fever associated with Chinese frozen whole egg; outbreaks in two bakeries. (13269854)
1955
30
PARATYPHOID fever and cream cakes. (13094092)
1953
31
Dissemination of paratyphoid fever from a bakery. (14824638)
1951
32
Two cases of paratyphoid fever treated with chloramphenicol. (14772491)
1950
33
Typhoid and paratyphoid fever; a review of four cases treated with chloromycetin. (15405410)
1950
34
A difficulty experienced in the bacteriological diagnosis of paratyphoid fever in cases treated with sulphonamides. (18130255)
1949
35
An outbreak of paratyphoid fever in Edmonton, Alta. (18894973)
1948
36
Field investigation of paratyphoid fever with typing of Salm. paratyphi B by means of Vi bacteriophage. (20262099)
1947
37
Pregnancy and typhoid, paratyphoid fever. (20246001)
1947
38
Paratyphoid fever. (20296482)
1946
39
Paratyphoid fever: an epidemiological study. (20475641)
1942
40
Paratyphoid Fever in Massachusetts. (18015087)
1939
41
Paratyphoid Fever and Aertrycke Enteritis in Aberdeen-a Contrast. (20474903)
1926
42
Discussion on Paratyphoid Fever. (19979288)
1916
43
DISCUSSION ON PARATYPHOID FEVER. (19979278)
1916
44
Discussion on Paratyphoid Fever. (19979286)
1916
45
DISCUSSION ON PARATYPHOID FEVER. (19979292)
1916
46
COMBINED PREVENTIVE INOCULATION AGAINST TYPHOID AND PARATYPHOID FEVER AND BACILLARY DYSENTERY. (20767977)
1916
47
Discussion on Paratyphoid Fever. (19979280)
1916
48
The AEtiology and Epidemiology of Paratyphoid Fever and "Food-poisoning.". (19975429)
1911
49
Report of an Epidemic of Probable Paratyphoid Fever. (19599427)
1910
50
Observations on the Bacteriology of Paratyphoid Fever and on the Reactions of Typhoid and Paratyphoid Sera. (20474245)
1906

Genetic Variations for Paratyphoid Fever

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Expression for genes affiliated with Paratyphoid Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paratyphoid Fever

Search GEO for disease gene expression data for Paratyphoid Fever.

Pathways for genes affiliated with Paratyphoid Fever

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Sources:
52R&D Systems, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN, 59Tocris Bioscience
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Pathways related to Paratyphoid Fever according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3IL1R1
210.1CXCL14
310.1IFNGR1, IFNG
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.0IFNG, IL1A
5
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9.9IL1A, IL12B, IFNGR1
6
Apoptosis and survival Caspase cascade
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9.9CASP1, TNFRSF1A, IL1A
79.9IL1B, IL12B, CASP1
89.9TNFRSF1A, IL1R1, IL1A
9
Hide members
9.9IFNG, IFNGR1, TNFRSF1A
109.9IL1B, IL1R1, TNFRSF1A
119.8IL1B, IL1A, CASP1
12
Hide members
9.8IL1B, IL1A, IL1R1
13
Hide members
9.8IL1B, IL1A, IL1R1
149.8IL1R1, IL1A, IL1B
159.8IL1R1, IL1A, IL1B
16
Hide members
9.8OGN, TNFRSF1A, IL12B
179.8IL1B, IFNGR1, IFNG
189.8IFNG, IL12B, IL1B
199.8IL1B, IL12B, IFNG
209.8IFNG, CRP, IL1B
219.7IL1B, IL1A, IL12B, CASP1
22
Hide members
9.6CASP1, IL1R1, IL1A, IL1B
23
Hide members
9.6CASP1, IL1R1, IL1A, IL1B
24
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9.6OGN, CXCL14, IL12B
25
Hide members
9.6IL1B, IL12B, IFNGR1, IFNG
26
Immune response IFN gamma signaling pathway
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9.6CASP1, IFNG, IFNGR1, IL1B
279.6IL1B, IL1R1, IL12B, IFNG
28
Hide members
9.6IFNG, IL12B, IL1R1, IL1B
299.6IL1B, IL1A, IL12B, IFNG
309.6IFNG, IL12B, IL1A, IL1B
31
Hide members
9.5IL1B, IL1A, IL1R1, TNFRSF1A, CASP1
32
Hide members
9.5CASP1, TNFRSF1A, IL1R1, IL1A, IL1B
33
Hide members
9.4IL1B, IL12B, TNFRSF1A, IFNGR1, IFNG
349.4CASP1, IFNG, IFNGR1, IL1A, IL1B
35
Immune response Bacterial infections in normal airways
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9.4IFNG, IFNGR1, IL1R1, IL1A, IL1B
36
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9.4IL1B, IL1A, IL1R1, IFNGR1, IFNG
37
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9.4OGN, TNFRSF1A, IL1R1, IL1A, IL1B
38
Hide members
9.3CASP1, TNFRSF1A, IL12B, IL1R1, IL1A, IL1B
39
Hide members
9.3OGN, TNFRSF1A, CXCL14, IL12B, IL1R1
40
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9.2CASP1, IFNG, IFNGR1, IL1R1, IL1A, IL1B
41
Hide members
9.2CASP1, IFNG, TNFRSF1A, HIST1H1A, HIST1H1D
429.2IFNG, IFNGR1, TNFRSF1A, IL12B, IL1A, IL1B
43
Hide members
9.2IFNG, IFNGR1, TNFRSF1A, IL12B, IL1A, IL1B
449.2IFNG, IFNGR1, TNFRSF1A, IL1R1, IL1A, IL1B
45
Hide members
9.2IFNG, IFNGR1, TNFRSF1A, IL1R1, IL1A, IL1B
46
Hide members
9.0CASP1, IFNG, IFNGR1, TNFRSF1A, IL12B, IL1A
47
Hide members
9.0CASP1, IFNG, IFNGR1, CTSC, IL1R1, IL1A
48
Hide members
8.9IL1A, CXCL14, HDAC11, TNFRSF1A, IFNGR1, CASP1
49
Hide members
8.8OGN, TNFRSF1A, CXCL14, IL12B, IL1R1, IL1A

Compounds for genes affiliated with Paratyphoid Fever

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Paratyphoid Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1amphotericin b4410.6IL1R1
2indomethacin44 59 28 1113.6IL1R1
3endotoxin4410.6CASP1, TNFRSF1A
4tenidap44 2811.5IL1R1, IL1A
5pirfenidone44 5911.4IL1B, IL1A
6pentoxifylline44 1111.4IL12B, IL1R1, CASP1
7gm-csf44 2811.3IFNG
8acetyl-tyr-val-ala-asp-cho4410.3CASP1, IL1B
9nh4cl4410.3CTSC, TNFRSF1A
10git 275910.2IL1A, IL1B, IL1R1
114-ipp5910.2IL1B, IL1A, IL1R1
12bucillamine4410.1CRP, IL1B, IFNG
13minocycline44 1111.1IL1A, CASP1, IL1B
14adalimumab44 49 1112.1IL1R1, IFNG, CRP
15auranofin44 59 28 1113.1IFNG, IL1A, IL1B
16imiquimod44 28 59 1113.1IL12B, IFNG, IL1A
17peptidoglycan44 2811.1IL1R1, CASP1, IL12B, IL1B
18staurosporin4410.1CASP1, IL1B, IFNG
19cuprophan4410.1CASP1, IL1R1, IL1B, TNFRSF1A
20anakinra44 1111.1IL1B, IL1R1, CRP, CASP1
21as 10159 4411.1IL1A, IL1R1, CASP1, IL1B
22polysulfone4410.1IL1B, IL1R1, CRP
23il-124410.0IL1B, IFNG, IL1R1, IL12B
24poly(i-c)4410.0IL12B, IL1B, IFNG, CASP1
25leflunomide49 44 1112.0TNFRSF1A, IL1B, IL1R1
26gold sodium thiomalate4410.0IFNG, IL1R1, IL1A, IL1B
27polyethylene glycol4410.0IL1R1, CRP, TNFRSF1A, IL1A
28polyinosinic-polycytidylic acid4410.0IFNG, IL1B, IL1A, IL12B
29okt34410.0IFNG, TNFRSF1A, CRP
30polymyxin b4410.0IL1A, IFNG, IL1B
31ccl344 2811.0IL1R1, IL1B, IL1A, IFNG
32lipoteichoic acid449.9IL1B, IL1R1, IL12B
33sulfasalazine44 28 49 1112.9IL1A, IL1R1, IL12B, CRP, IL1B
34il 10449.8IL12B, IL1B, IL1A, IL1R1, IFNG
35ns 39844 5910.8IL1B, IL1A, TNFRSF1A
36etanercept44 49 1111.8IL1B, CRP, TNFRSF1A, IFNG, IL1R1
37infliximab44 49 1111.8IL1B, IL1R1, CRP, IFNG, TNFRSF1A
38thalidomide44 49 59 1112.8IL1A, IL1B, IL1R1, TNFRSF1A, IFNG
39ribonucleic acid449.8IL1R1, IL1B, IL1A, TNFRSF1A, CASP1
40n acetylcysteine449.8TNFRSF1A, CRP, IL1R1, CASP1, IL1B
41rantes449.6IL1A, IL1B, IFNG, TNFRSF1A, IL12B, IL1R1
42ivig449.6IL1R1, CRP, TNFRSF1A, IFNG, IL1A, IL1B
43neopterin449.6IFNG, CRP, IL1R1, TNFRSF1A, IL1B, IL1A
44actinomycin d449.6IFNG, CASP1, TNFRSF1A, IL1B, IL1A, IL1R1
45simvastatin44 49 59 28 11 2414.6TNFRSF1A, IL1A, IFNG, CRP
46s-nitroso-n-acetylpenicillamine449.5IL1B, CASP1, IFNG
47herbimycin a44 5910.5IL1A, IL1B, TNFRSF1A, IFNG
48nitric oxide44 11 2411.4CASP1, TNFRSF1A, IL12B, IL1R1, IL1A, IFNG
49vegf449.3IFNG, IL1B, CASP1, TNFRSF1A, CRP, IL1R1
50sb 20358044 5910.2TNFRSF1A, IFNG, CRP, IL12B, IL1R1, IL1A

GO Terms for genes affiliated with Paratyphoid Fever

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16Gene Ontology
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Cellular components related to Paratyphoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.7OGN, IFNG, TNFRSF1A, CRP, IL1R1, IL1A
2extracellular spaceGO:0056158.2IL1B, OGN, IFNG, TNFRSF1A, CRP, CXCL14

Biological processes related to Paratyphoid Fever according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1interleukin-1 beta productionGO:03261110.3CASP1, IL1B
2fever generationGO:00166010.3IL1B, IL1A
3positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.3IL12B, IL1B
4positive regulation of calcidiol 1-monooxygenase activityGO:06055910.3IFNG, IL1B
5positive regulation of smooth muscle cell apoptotic processGO:03439310.3IL12B, IFNG
6negative regulation of interleukin-17 productionGO:03270010.2IFNG, IL12B
7positive regulation of interleukin-6 biosynthetic processGO:04541010.2IL1B, IFNG
8positive regulation of tumor necrosis factor productionGO:03276010.2IL12B, TNFRSF1A, IFNG
9positive regulation of chemokine biosynthetic processGO:04508010.2IFNG, IL1B
10positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.1TNFRSF1A, IFNG
11cellular response to mechanical stimulusGO:07126010.1IL1B, TNFRSF1A, CASP1
12negative regulation of smooth muscle cell proliferationGO:04866210.1OGN, IFNG, IL12B
13positive regulation of T cell proliferationGO:04210210.1IL1B, IL12B, IFNG
14positive regulation of interleukin-2 biosynthetic processGO:04508610.0IL1B, IL1A
15positive regulation of angiogenesisGO:0457669.9TNFRSF1A, IL1A, IL1B
16positive regulation of membrane protein ectodomain proteolysisGO:0510449.9IL1B, IFNG
17cytokine-mediated signaling pathwayGO:0192219.7IL1B, IL1A, TNFRSF1A, IFNGR1, IFNG
18immune responseGO:0069559.5IL1B, IL1A, IL1R1, CXCL14, CTSC
19apoptotic processGO:0069159.4IL1B, IL1A, TNFRSF1A, IFNG, CASP1
20inflammatory responseGO:0069549.3TNFRSF1A, CRP, IL1A, IL1B

Molecular functions related to Paratyphoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.0IL1B, IL1A
2cytokine activityGO:0051259.3IL1B, IL1A, IL12B, IFNG

Products for genes affiliated with Paratyphoid Fever

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Sources for Paratyphoid Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet