MCID: PRT002
MIFTS: 54

Paratyphoid Fever malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Paratyphoid Fever

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Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 45NCIt, 54Orphanet, 62SNOMED-CT, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Paratyphoid Fever:

Name: Paratyphoid Fever 11 54 39 13 68
Paratyphoid B Fever 11 68
Paratyphoid C Fever 11 68
Paratyphoid Fever B 11
Paratyphoid a Fever 11
Paratyphoid Fever C 11
 
Paratyphoid Fever a 11
Paratyphoid a 11
Paratyphoid B 11
Paratyphoid C 11
Paratyphoid 11

Characteristics:

Orphanet epidemiological data:

54
paratyphoid fever:
Inheritance: Not applicable

Classifications:



Summaries for Paratyphoid Fever

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Disease Ontology:11 A primary bacterial infectious disease that results in infection located in intestine, has material basis in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted by ingestion of contaminated food. The infection has symptom fever, has symptom headache, has symptom abdominal pain, has symptom malaise, has symptom anorexia, has symptom constipation, has symptom rosy spots on the central body, has symptom non productive cough (in early stage of illness), has symptom bradycardia, and has symptom hepatosplenomegaly.

MalaCards based summary: Paratyphoid Fever, also known as paratyphoid b fever, is related to typhoid fever and salmonellosis, and has symptoms including fever, headache and abdominal pain. An important gene associated with Paratyphoid Fever is IFNGR1 (Interferon Gamma Receptor 1), and among its related pathways are Transcription_NF-kB signaling pathway and Hypertrophy Model. Affiliated tissues include intestine, skin and testes, and related mouse phenotypes are craniofacial and endocrine/exocrine gland.

Wikipedia:71 Paratyphoid fever, also known simply as paratyphoid, is a bacterial infection caused by one of the three... more...

Related Diseases for Paratyphoid Fever

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Diseases related to Paratyphoid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1typhoid fever11.5
2salmonellosis10.9
3intravascular papillary endothelial hyperplasia10.2IFNG, IFNGR1
4crustacean allergy10.2IFNG, IFNGR1
5variola minor10.1IFNG, IFNGR1
6chromosome 16p11.2 duplication syndrome autism, susceptibility to, 14b, included10.1CASP1, IL1B
7egg allergy10.1IL1B, IL1R1
8chondrodysplasia punctata, rhizomelic, type 110.1IFNGR1, IL1B
9warthin tumor10.1IL1B, IL1R1
10juvenile amyotrophic lateral sclerosis with dementia10.1CASP1, TNFRSF1A
11primary ciliary dyskinesia10.1IL1R1, TNFRSF1A
12amelanotic melanoma10.1CASP1, IL1B
13anal atresia, hypospadias, and penoscrotal inversion10.1IFNG, IFNGR1
14microcephaly10.1IFNG, IFNGR1
15stocco dos santos syndrome10.1IFNG, IL1B
16benign neonatal seizures10.1IL1B, IL1R1
17ethmoid sinus cancer10.1IFNG, IL1B
18cerebrum cancer10.0IL1B, TNFRSF1A
19amyotrophic lateral sclerosis type 1410.0IFNG, IL1B
20parkinson disease 1110.0IFNG, IL1B
21rosacea10.0IFNG, IL1B
22ectodermal dysplasia bartalos type10.0IFNG, IL1B
23rickettsialpox10.0IFNG, IL1B
24keratoconus10.0IL1B, IL1R1
25periventricular leukomalacia10.0IFNG, IL1B
26oral cavity carcinoma in situ10.0IFNG, IL1B
27familial hyperthyroidism due to mutations in tsh receptor10.0CASP1, IL1B, IL1R1
28benign eccrine breast spiradenoma9.9IFNG, IFNGR1, IL1B
29senile reticular retinal degeneration9.9IFNG, IL1B, IL1R1
30dysentery9.9
31respiratory system disease9.9IFNG, IL1B, IL1R1
32bare lymphocyte syndrome, type i9.9IFNG, IL1B, IL1R1
33patau syndrome9.9IL1B, TNFRSF1A
34status epilepticus9.9IFNG, IL1B
35gastric leiomyoma9.9IL12B, IL1B
36pyloric stenosis, infantile hypertrophic, 29.9CASP1, IL1B, TNFRSF1A
37keratomalacia9.9CASP1, IFNG, IL1B
38aortic aneurysm, familial thoracic 69.9IFNG, IL1B, IL1R1
39pancreas lymphoma9.9IL1B, TNFRSF1A
40complex regional pain syndrome9.9IFNG, IL1B, TNFRSF1A
41ectothrix infectious disease9.9IFNG, IL12B
42goodpasture syndrome9.9IFNG, IL1B, TNFRSF1A
43advanced sleep phase syndrome, familial, 19.9IFNG, IL1B, TNFRSF1A
44nasopharyngitis9.8IFNG, IL1B
45hepatitis9.8
46hepatitis b9.8
47ileitis9.8
48nephrotic syndrome9.8
49hepatitis a9.8
50biliary atresia9.8

Graphical network of the top 20 diseases related to Paratyphoid Fever:



Diseases related to paratyphoid fever

Symptoms & Phenotypes for Paratyphoid Fever

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Symptoms:

 11 (show all 10)
  • fever
  • headache
  • abdominal pain
  • malaise
  • anorexia
  • constipation
  • rosy spots on the central body
  • non productive cough (in early stage of illness)
  • bradycardia
  • hepatosplenomegaly

MGI Mouse Phenotypes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

41 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.1IFNG, IL12B, IL1R1, TNFRSF1A
2MP:00053799.1CASP1, IFNG, IFNGR1, IL1R1, TNFRSF1A
3MP:00053678.9CASP1, IFNG, IFNGR1, IL1R1, TNFRSF1A
4MP:00053818.6CASP1, IFNG, IFNGR1, IL12B, TNFRSF1A
5MP:00053858.4CASP1, IFNG, IFNGR1, IL1B, IL1R1, TNFRSF1A
6MP:00107718.4CASP1, IFNG, IFNGR1, IL1B, IL1R1, TNFRSF1A
7MP:00036318.3CASP1, IFNG, IFNGR1, IL1B, IL1R1, TNFRSF1A
8MP:00053977.6CASP1, IFNG, IFNGR1, IL12B, IL1B, IL1R1
9MP:00053767.6CASP1, IFNG, IFNGR1, IL12B, IL1B, IL1R1
10MP:00053877.6CASP1, IFNG, IFNGR1, IL12B, IL1B, IL1R1
11MP:00107687.6CASP1, IFNG, IFNGR1, IL12B, IL1B, IL1R1
12MP:00020067.6CASP1, IFNG, IFNGR1, IL12B, IL1B, IL1R1
13MP:00053907.2IFNG, IFNGR1, IL12B, IL1B, IL1R1, TNFRSF1A

Drugs & Therapeutics for Paratyphoid Fever

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Drugs for Paratyphoid Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 4, Phase 1, Phase 26611
2Pharmaceutical SolutionsPhase 1, Phase 28192
3Liver ExtractsPhase 1, Phase 24067
4LecithinNutraceuticalPhase 1, Phase 274
5Soy BeanNutraceuticalPhase 1, Phase 2554

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central VietnamCompletedNCT00131820Phase 4
2Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, ChinaCompletedNCT00131833Phase 4
3Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in ChildhoodCompletedNCT00125047Phase 4
4Evaluation of the Vi Polysaccharide Vaccine Against Typhoid FeverCompletedNCT00125008Phase 4
5TY800 Dose Escalation (Typhoid)CompletedNCT00269295Phase 1, Phase 2
6Safety and Efficacy Study of Mix Vaccine in Prostate Carcinoma PatientCompletedNCT02338700Phase 1, Phase 2
7Safety and Efficacy Study of Mix Vaccine in Breast Carcinoma PatientCompletedNCT02338804Phase 1, Phase 2
8Safety and Efficacy Study of Mix Vaccine in Hepatocyte Carcinoma PatientCompletedNCT02338778Phase 1, Phase 2
9Safety and Efficacy Study of Mix Vaccine in Pancreatic Carcinoma PatientCompletedNCT02338752Phase 1, Phase 2
10Investigating Enteric Fever - Salmonella Typhi and Paratyphi Challenge StudyRecruitingNCT02192008
11Investigating Typhoid Fever PathogenesisRecruitingNCT03067961
12Understanding Paratyphoid InfectionActive, not recruitingNCT02100397

Search NIH Clinical Center for Paratyphoid Fever


Cochrane evidence based reviews: paratyphoid fever

Genetic Tests for Paratyphoid Fever

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Anatomical Context for Paratyphoid Fever

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MalaCards organs/tissues related to Paratyphoid Fever:

36
Skin, Testes, Bone, Bone marrow

FMA organs/tissues related to Paratyphoid Fever:

17
Intestine

Publications for Paratyphoid Fever

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Articles related to Paratyphoid Fever:

(show top 50)    (show all 132)
idTitleAuthorsYear
1
Status of paratyphoid fever vaccine research and development. (27083427)
2016
2
Six Cases of Paratyphoid Fever Due to Salmonella Paratyphi A in Travelers Returning from Myanmar Between July 2014 and August 2015. (27352874)
2016
3
Increase in paratyphoid fever cases in Japanese travellers returning from Cambodia in 2013. (26169980)
2015
4
A Large-Scale Community-Based Outbreak of Paratyphoid Fever Caused by Hospital-Derived Transmission in Southern China. (26186586)
2015
5
Recurrent paratyphoid fever A co-infected with hepatitis A reactivated chronic hepatitis B. (24884719)
2014
6
Paratyphoid fever: splicing the global analyses. (24904229)
2014
7
Typhoid and paratyphoid fever. (24707582)
2014
8
Psychosis in paratyphoid fever - a case report from Australia. (24820292)
2014
9
The application of the grey disaster model to forecast epidemic peaks of typhoid and paratyphoid fever in China. (23565260)
2013
10
Correction: The Application of the Grey Disaster Model to Forecast Epidemic Peaks of Typhoid and Paratyphoid Fever in China. (24039655)
2013
11
Spatiotemporal transmission and determinants of typhoid and paratyphoid fever in Hongta District, Yunnan Province, China. (23516653)
2013
12
Typhoid fever and paratyphoid fever: Systematic review to estimate global morbidity and mortality for 2010. (23198130)
2012
13
Study of clinical profile and antibiotic sensitivity in paratyphoid Fever cases admitted at teaching hospital in South India. (24479019)
2012
14
Association between the incidence of typhoid and paratyphoid fever and meteorological variables in Guizhou, China. (22490402)
2012
15
Typhoid and paratyphoid fever in Western Sydney Local Health District, NSW, January-June 2011. (23043747)
2012
16
WITHDRAWN: Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever). (21975751)
2011
17
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (21975746)
2011
18
Typhoid and paratyphoid fever - prevention in travellers. (21301658)
2010
19
Global trends in typhoid and paratyphoid Fever. (20014951)
2010
20
Burden of typhoid and paratyphoid fever in a densely populated urban community, Dhaka, Bangladesh. (20236850)
2010
21
Yields from blood cultures of patients with suspected paratyphoid fever A. (24031492)
2010
22
Epidemiology of typhoid and paratyphoid fever hospitalizations in Spain (1997-2005). (19276655)
2009
23
Study on blood cultures and bacteria counts in the blood of paratyphoid fever A patients. (19526258)
2009
24
Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever). (18843701)
2008
25
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (18843659)
2008
26
Epidemiology of typhoid and paratyphoid fever in India. (19745523)
2008
27
Laboratory-based surveillance of paratyphoid fever in the United States: travel and antimicrobial resistance. (18422453)
2008
28
Comparisons of predictors for typhoid and paratyphoid fever in Kolkata, India. (17935611)
2007
29
Ty21a live oral typhoid vaccine and prevention of paratyphoid fever caused by Salmonella enterica Serovar Paratyphi B. (17582564)
2007
30
Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever. (17477815)
2007
31
Deep-seated resistance in relapsed paratyphoid fever. (16652303)
2006
32
PARK2/PACRG polymorphisms and susceptibility to typhoid and paratyphoid fever. (16734611)
2006
33
Typhoid and paratyphoid fever. (16125594)
2005
34
Identification of typhoid fever and paratyphoid fever cases at presentation in outpatient clinics in Jakarta, Indonesia. (15837356)
2005
35
Paratyphoid fever in Vellore, South India. (16105360)
2005
36
Typhoid and paratyphoid fever. (16271635)
2005
37
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (15846718)
2005
38
Epidemiology of typhoid and paratyphoid fever in Kathmandu: two years study and trends of antimicrobial resistance. (16082406)
2005
39
Typhoid and paratyphoid fever. (16271636)
2005
40
Typhoid and paratyphoid fever in travellers. (16183516)
2005
41
Risk factors for typhoid and paratyphoid fever in Jakarta, Indonesia. (15173152)
2004
42
LipschA1tz genital ulceration: a rare manifestation of paratyphoid fever. (12804994)
2003
43
An unusual paratyphoid fever. (11762624)
2001
44
Typhoid and paratyphoid fever: a 10-year retrospective study of 41 cases in a Parisian hospital. (11726293)
2001
45
Typhoid and paratyphoid fever in south-eastern Sydney, 1992-1997. (11022389)
2000
46
Oral administration of fluoroquinolones in the treatment of typhoid fever and paratyphoid fever in Japan. (11197787)
2000
47
Epidemiological studies of an outbreak of paratyphoid fever in the Shima area of Mie Prefecture. (10738368)
1999
48
Paratyphoid fever in India: An emerging problem. (10341194)
1999
49
A relapse of paratyphoid fever after treatment with ciprofloxacin in a child with congenital biliary atresia. (9183498)
1997
50
Paratyphoid fever due to Salmonella enterica serotype Paratyphi A. (9284393)
1997

Variations for Paratyphoid Fever

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Expression for genes affiliated with Paratyphoid Fever

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Search GEO for disease gene expression data for Paratyphoid Fever.

Pathways for genes affiliated with Paratyphoid Fever

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Pathways related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idSuper pathwaysScoreTop Affiliating Genes
19.5IL1R1, TNFRSF1A
29.5IFNG, IL1R1
3
Show member pathways
9.4IL1B, IL1R1
4
Show member pathways
9.4IFNG, TNFRSF1A
59.4IFNG, TNFRSF1A
69.4IFNG, TNFRSF1A
79.4CASP1, IL1B
89.4CASP1, IL1B
99.4CASP1, IL1B
109.3IFNG, IL1B
119.3IFNG, IL1B
12
Show member pathways
9.1IFNG, IL12B
13
Show member pathways
9.1IFNG, IFNGR1, TNFRSF1A
149.1IFNG, IFNGR1, TNFRSF1A
159.0IL12B, IL1B
16
Show member pathways
9.0CASP1, IL1B, IL1R1
179.0IFNG, IFNGR1, IL1B
188.9IL1B, IL1R1, TNFRSF1A
198.9IFNG, IL1B, IL1R1
208.9IFNG, IL1B, IL1R1
218.9IFNG, IL1B, IL1R1
22
Show member pathways
8.8IFNG, IL1B, TNFRSF1A
238.8IFNG, IL1B, TNFRSF1A
24
Show member pathways
8.8IFNG, IFNGR1, IL12B
258.8IFNG, IFNGR1, IL12B
268.6CASP1, IL12B, IL1B
278.6CASP1, IL12B, IL1B
28
Show member pathways
8.5IFNG, IFNGR1, IL1B, IL1R1
29
Show member pathways
8.5IFNG, IFNGR1, IL1B, IL1R1
30
Show member pathways
8.5IFNG, IL12B, IL1B
318.5IFNG, IL12B, IL1B
328.5IFNG, IL12B, IL1B
338.5IFNG, IL12B, IL1B
34
Show member pathways
8.5IFNG, IL12B, IL1B
358.5IFNG, IL12B, IL1B
368.5IFNG, IL12B, IL1B
37
Show member pathways
8.5CASP1, IFNG, IFNGR1, IL1B
38
Show member pathways
8.5CASP1, IFNG, IFNGR1, IL1B
39
Show member pathways
8.5CASP1, IL1B, IL1R1, TNFRSF1A
408.4IFNG, IL1B, IL1R1, TNFRSF1A
41
Show member pathways
8.2IFNG, IFNGR1, IL12B, TNFRSF1A
42
Show member pathways
8.1IFNG, IFNGR1, IL12B, IL1B
438.1IL12B, IL1B, IL1R1, TNFRSF1A
448.1IFNG, IL12B, IL1B, IL1R1
45
Show member pathways
8.1IFNG, IL12B, IL1B, IL1R1
46
Show member pathways
8.1IFNG, IL12B, IL1B, IL1R1
47
Show member pathways
8.1CASP1, IFNG, IL12B, IL1B
488.0IFNG, IFNGR1, IL1B, IL1R1, TNFRSF1A
49
Show member pathways
8.0IFNG, IFNGR1, IL1B, IL1R1, TNFRSF1A
50
Show member pathways
8.0IFNG, IFNGR1, IL1B, IL1R1, TNFRSF1A

GO Terms for genes affiliated with Paratyphoid Fever

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Cellular components related to Paratyphoid Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.1CASP1, IFNG, IL12B, IL1B, IL1R1, TNFRSF1A

Biological processes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1regulation of interferon-gamma-mediated signaling pathwayGO:006033410.3IFNG, IFNGR1
2positive regulation of interleukin-1 beta secretionGO:005071810.3CASP1, IFNG
3positive regulation of tyrosine phosphorylation of Stat1 proteinGO:004251110.2IFNG, TNFRSF1A
4cellular response to organic substanceGO:007131010.2CASP1, IL1B
5interleukin-1 beta productionGO:003261110.2CASP1, IL1B
6response to ATPGO:003319810.1CASP1, IL1B
7positive regulation of calcidiol 1-monooxygenase activityGO:006055910.1IFNG, IL1B
8positive regulation of chemokine biosynthetic processGO:004508010.1IFNG, IL1B
9positive regulation of interleukin-6 biosynthetic processGO:004541010.1IFNG, IL1B
10positive regulation of membrane protein ectodomain proteolysisGO:005104410.1IFNG, IL1B
11positive regulation of nitric oxide biosynthetic processGO:004542910.1IFNG, IL1B
12regulation of establishment of endothelial barrierGO:190314010.1IL1B, TNFRSF1A
13regulation of defense response to virus by hostGO:005069110.1IFNG, IL1B
14defense response to protozoanGO:00428329.9IFNG, IL12B
15negative regulation of growth of symbiont in hostGO:00441309.9IFNG, IL12B
16negative regulation of interleukin-17 productionGO:00327009.9IFNG, IL12B
17negative regulation of smooth muscle cell proliferationGO:00486629.9IFNG, IL12B
18positive regulation of cell adhesionGO:00457859.9IFNG, IL12B
19positive regulation of inflammatory responseGO:00507299.9IL12B, TNFRSF1A
20positive regulation of interleukin-12 productionGO:00327359.9IFNG, IL12B
21positive regulation of osteoclast differentiationGO:00456729.9IFNG, IL12B
22positive regulation of smooth muscle cell apoptotic processGO:00343939.9IFNG, IL12B
23positive regulation of tumor necrosis factor productionGO:00327609.9IFNG, IL12B
24positive regulation of granulocyte macrophage colony-stimulating factor productionGO:00327259.8IL12B, IL1B
25positive regulation of interferon-gamma productionGO:00327299.8IL12B, IL1B
26positive regulation of NF-kappaB import into nucleusGO:00423469.8IL12B, IL1B
27cellular response to mechanical stimulusGO:00712609.7CASP1, IL1B, TNFRSF1A
28positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.6CASP1, IL1B, TNFRSF1A
29response to lipopolysaccharideGO:00324969.6CASP1, IL1B, TNFRSF1A
30defense response to virusGO:00516079.5IFNG, IFNGR1, IL12B
31positive regulation of tyrosine phosphorylation of STAT proteinGO:00425319.4IFNG, IL12B, TNFRSF1A
32positive regulation of T cell proliferationGO:00421029.3IFNG, IL12B, IL1B
33immune responseGO:00069559.2IFNG, IL1B, IL1R1, TNFRSF1A
34apoptotic processGO:00069159.1CASP1, IFNG, IL1B, TNFRSF1A
35cell surface receptor signaling pathwayGO:00071669.0IFNG, IL12B, IL1R1, TNFRSF1A
36cytokine-mediated signaling pathwayGO:00192218.9IL12B, IL1B, IL1R1, TNFRSF1A
37signal transductionGO:00071658.1CASP1, IFNGR1, IL1B, IL1R1, TNFRSF1A

Molecular functions related to Paratyphoid Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.5IFNG, IL12B, IL1B

Sources for Paratyphoid Fever

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet