MCID: PRT002
MIFTS: 52

Paratyphoid Fever malady

Categories: Infectious diseases, Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Paratyphoid Fever

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Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 45NCIt, 54Orphanet, 62SNOMED-CT, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Paratyphoid Fever:

Name: Paratyphoid Fever 11 54 39 13 68
Paratyphoid B Fever 11 68
Paratyphoid C Fever 11 68
Paratyphoid Fever B 11
Paratyphoid a Fever 11
Paratyphoid Fever C 11
 
Paratyphoid Fever a 11
Paratyphoid a 11
Paratyphoid B 11
Paratyphoid C 11
Paratyphoid 11

Characteristics:

Orphanet epidemiological data:

54
paratyphoid fever:
Inheritance: Not applicable

Classifications:



Summaries for Paratyphoid Fever

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Disease Ontology:11 A primary bacterial infectious disease that results in infection located in intestine, has material basis in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted by ingestion of contaminated food. The infection has symptom fever, has symptom headache, has symptom abdominal pain, has symptom malaise, has symptom anorexia, has symptom constipation, has symptom rosy spots on the central body, has symptom non productive cough (in early stage of illness), has symptom bradycardia, and has symptom hepatosplenomegaly.

MalaCards based summary: Paratyphoid Fever, also known as paratyphoid b fever, is related to typhoid fever and primary biliary cirrhosis, and has symptoms including fever, headache and abdominal pain. An important gene associated with Paratyphoid Fever is IFNGR1 (Interferon Gamma Receptor 1), and among its related pathways are Jak/STAT Signaling Pathway and Cellular Transformation by HTLV1. Affiliated tissues include intestine, skin and prostate, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and Synthetic lethal with MLN4924 (a NAE inhibitor).

Wikipedia:71 Paratyphoid fever, also known simply as paratyphoid, is a bacterial infection caused by one of the three... more...

Related Diseases for Paratyphoid Fever

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Diseases related to Paratyphoid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1typhoid fever11.5
2primary biliary cirrhosis10.0IL1R1, TNFRSF1A
3immunodeficiency 27b, mycobacteriosis, ad9.9IFNGR1, IL1B
4dysentery9.9
5warm antibody hemolytic anemia9.9IL1B, IL1R1
6askin's tumor9.9IFNGR1, IL1B
7keloids9.9IL1B, IL1R1
8dystonia 17, torsion, autosomal recessive9.8CASP1, IL1B
9lymphocele9.8CASP1, IL1B
10syphilitic encephalitis9.8IL12B, IL1B
11hepatitis9.8
12hepatitis b9.8
13ileitis9.8
14hepatitis a9.8
15biliary atresia9.8
16purpura9.8
17appendicitis9.8
18duodenitis9.8
19vasculitis9.8
20keratosis9.7IFNGR1, IL1B
21bacteremia9.7
22aortic aneurysm9.7
23aneurysm9.7
24kidney rhabdoid cancer9.7IL1B, TNFRSF1A
25nasopharyngitis9.7CASP1, IL1B
26pediatric supratentorial ependymoma9.7IL12B, IL1B
27pulmonary systemic sclerosis9.6IL1B, IL1R1
28nephrosclerosis9.6IL1B, TNFRSF1A
29benign peritoneal mesothelioma9.6IL1B, TNFRSF1A
30cutaneous porphyria9.5CASP1, IFNGR1, IL1B
31pleomorphic lipoma9.5CASP1, IFNGR1, IL1B
32lethal midline granuloma9.5IFNGR1, IL12B, IL1B
33familial dupuytren contracture9.5CASP1, IL1B, IL1R1
34ovary transitional cell carcinoma9.5IFNGR1, IL12B, IL1B
35myelitis9.5IL1B, TNFRSF1A
36uterine inversion9.4IL1B, TNFRSF1A
37pyloric stenosis, infantile hypertrophic, 29.3CASP1, IL1B, TNFRSF1A
38low compliance bladder9.3IL12B, IL1B
39familial cold-induced inflammatory syndrome 19.0CASP1, IL1B, IL1R1, TNFRSF1A
40astrocytoma9.0CASP1, IFNGR1, IL1R1, PARK2, TNFRSF1A
41cinca syndrome9.0CASP1, IL1B, IL1R1, TNFRSF1A
42muckle-wells syndrome9.0CASP1, IL1B, IL1R1, TNFRSF1A
43malaria8.5CASP1, IFNGR1, IL12B, IL1B, TNFRSF1A

Graphical network of the top 20 diseases related to Paratyphoid Fever:



Diseases related to paratyphoid fever

Symptoms & Phenotypes for Paratyphoid Fever

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Symptoms:

 11 (show all 10)
  • fever
  • headache
  • abdominal pain
  • malaise
  • anorexia
  • constipation
  • rosy spots on the central body
  • non productive cough (in early stage of illness)
  • bradycardia
  • hepatosplenomegaly

GenomeRNAi Phenotypes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-358.8IL1B, IL1R1, PARK2
2GR00250-A-16.1CASP1, IL1B, PARK2, TNFRSF1A, CASP1, IL1B

MGI Mouse Phenotypes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.8CASP1, IFNGR1, IL1R1, TNFRSF1A
2MP:00053907.7IFNGR1, IL12B, IL1B, IL1R1, PARK2, TNFRSF1A
3MP:00107717.7CASP1, IFNGR1, IL1B, IL1R1, PARK2, TNFRSF1A
4MP:00020067.6CASP1, IFNGR1, IL12B, IL1B, IL1R1, TNFRSF1A
5MP:00053877.6CASP1, IFNGR1, IL12B, IL1B, IL1R1, TNFRSF1A
6MP:00053977.6CASP1, IFNGR1, IL12B, IL1B, IL1R1, TNFRSF1A
7MP:00036317.5CASP1, IFNGR1, IL1B, IL1R1, PARK2, TNFRSF1A
8MP:00053857.5CASP1, IFNGR1, IL1B, IL1R1, PARK2, TNFRSF1A
9MP:00107687.0CASP1, IFNGR1, IL12B, IL1B, IL1R1, PARK2
10MP:00053767.0CASP1, IFNGR1, IL12B, IL1B, IL1R1, PARK2

Drugs & Therapeutics for Paratyphoid Fever

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Drugs for Paratyphoid Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 4, Phase 1, Phase 26428
2Pharmaceutical SolutionsPhase 1, Phase 27793
3Liver ExtractsPhase 1, Phase 23868
4LecithinNutraceuticalPhase 1, Phase 270
5Soy BeanNutraceuticalPhase 1, Phase 2535

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central VietnamCompletedNCT00131820Phase 4
2Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, ChinaCompletedNCT00131833Phase 4
3Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in ChildhoodCompletedNCT00125047Phase 4
4Evaluation of the Vi Polysaccharide Vaccine Against Typhoid FeverCompletedNCT00125008Phase 4
5TY800 Dose Escalation (Typhoid)CompletedNCT00269295Phase 1, Phase 2
6Safety and Efficacy Study of Mix Vaccine in Prostate Carcinoma PatientCompletedNCT02338700Phase 1, Phase 2
7Safety and Efficacy Study of Mix Vaccine in Breast Carcinoma PatientCompletedNCT02338804Phase 1, Phase 2
8Safety and Efficacy Study of Mix Vaccine in Hepatocyte Carcinoma PatientCompletedNCT02338778Phase 1, Phase 2
9Safety and Efficacy Study of Mix Vaccine in Pancreatic Carcinoma PatientCompletedNCT02338752Phase 1, Phase 2
10Investigating Enteric Fever - Salmonella Typhi and Paratyphi Challenge StudyRecruitingNCT02192008
11Understanding Paratyphoid InfectionActive, not recruitingNCT02100397

Search NIH Clinical Center for Paratyphoid Fever


Cochrane evidence based reviews: paratyphoid fever

Genetic Tests for Paratyphoid Fever

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Anatomical Context for Paratyphoid Fever

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MalaCards organs/tissues related to Paratyphoid Fever:

36
Skin, Prostate, Liver, Testes, Bone, Bone marrow

FMA organs/tissues related to Paratyphoid Fever:

17
Intestine

Publications for Paratyphoid Fever

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Articles related to Paratyphoid Fever:

(show top 50)    (show all 132)
idTitleAuthorsYear
1
Six Cases of Paratyphoid Fever Due to Salmonella Paratyphi A in Travelers Returning from Myanmar Between July 2014 and August 2015. (27352874)
2016
2
Status of paratyphoid fever vaccine research and development. (27083427)
2016
3
A Large-Scale Community-Based Outbreak of Paratyphoid Fever Caused by Hospital-Derived Transmission in Southern China. (26186586)
2015
4
Increase in paratyphoid fever cases in Japanese travellers returning from Cambodia in 2013. (26169980)
2015
5
Psychosis in paratyphoid fever - a case report from Australia. (24820292)
2014
6
Recurrent paratyphoid fever A co-infected with hepatitis A reactivated chronic hepatitis B. (24884719)
2014
7
Paratyphoid fever: splicing the global analyses. (24904229)
2014
8
Typhoid and paratyphoid fever. (24707582)
2014
9
Correction: The Application of the Grey Disaster Model to Forecast Epidemic Peaks of Typhoid and Paratyphoid Fever in China. (24039655)
2013
10
The application of the grey disaster model to forecast epidemic peaks of typhoid and paratyphoid fever in China. (23565260)
2013
11
Spatiotemporal transmission and determinants of typhoid and paratyphoid fever in Hongta District, Yunnan Province, China. (23516653)
2013
12
Study of clinical profile and antibiotic sensitivity in paratyphoid Fever cases admitted at teaching hospital in South India. (24479019)
2012
13
Typhoid and paratyphoid fever in Western Sydney Local Health District, NSW, January-June 2011. (23043747)
2012
14
Association between the incidence of typhoid and paratyphoid fever and meteorological variables in Guizhou, China. (22490402)
2012
15
Typhoid fever and paratyphoid fever: Systematic review to estimate global morbidity and mortality for 2010. (23198130)
2012
16
WITHDRAWN: Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever). (21975751)
2011
17
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (21975746)
2011
18
Typhoid and paratyphoid fever - prevention in travellers. (21301658)
2010
19
Global trends in typhoid and paratyphoid Fever. (20014951)
2010
20
Burden of typhoid and paratyphoid fever in a densely populated urban community, Dhaka, Bangladesh. (20236850)
2010
21
Yields from blood cultures of patients with suspected paratyphoid fever A. (24031492)
2010
22
Study on blood cultures and bacteria counts in the blood of paratyphoid fever A patients. (19526258)
2009
23
Epidemiology of typhoid and paratyphoid fever hospitalizations in Spain (1997-2005). (19276655)
2009
24
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (18843659)
2008
25
Epidemiology of typhoid and paratyphoid fever in India. (19745523)
2008
26
Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever). (18843701)
2008
27
Laboratory-based surveillance of paratyphoid fever in the United States: travel and antimicrobial resistance. (18422453)
2008
28
Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever. (17477815)
2007
29
Comparisons of predictors for typhoid and paratyphoid fever in Kolkata, India. (17935611)
2007
30
Ty21a live oral typhoid vaccine and prevention of paratyphoid fever caused by Salmonella enterica Serovar Paratyphi B. (17582564)
2007
31
PARK2/PACRG polymorphisms and susceptibility to typhoid and paratyphoid fever. (16734611)
2006
32
Deep-seated resistance in relapsed paratyphoid fever. (16652303)
2006
33
Paratyphoid fever in Vellore, South India. (16105360)
2005
34
Typhoid and paratyphoid fever in travellers. (16183516)
2005
35
Typhoid and paratyphoid fever. (16271635)
2005
36
Typhoid and paratyphoid fever. (16125594)
2005
37
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (15846718)
2005
38
Identification of typhoid fever and paratyphoid fever cases at presentation in outpatient clinics in Jakarta, Indonesia. (15837356)
2005
39
Epidemiology of typhoid and paratyphoid fever in Kathmandu: two years study and trends of antimicrobial resistance. (16082406)
2005
40
Typhoid and paratyphoid fever. (16271636)
2005
41
Risk factors for typhoid and paratyphoid fever in Jakarta, Indonesia. (15173152)
2004
42
LipschA1tz genital ulceration: a rare manifestation of paratyphoid fever. (12804994)
2003
43
Typhoid and paratyphoid fever: a 10-year retrospective study of 41 cases in a Parisian hospital. (11726293)
2001
44
An unusual paratyphoid fever. (11762624)
2001
45
Oral administration of fluoroquinolones in the treatment of typhoid fever and paratyphoid fever in Japan. (11197787)
2000
46
Typhoid and paratyphoid fever in south-eastern Sydney, 1992-1997. (11022389)
2000
47
Paratyphoid fever in India: An emerging problem. (10341194)
1999
48
Epidemiological studies of an outbreak of paratyphoid fever in the Shima area of Mie Prefecture. (10738368)
1999
49
Paratyphoid fever due to Salmonella enterica serotype Paratyphi A. (9284393)
1997
50
A relapse of paratyphoid fever after treatment with ciprofloxacin in a child with congenital biliary atresia. (9183498)
1997

Variations for Paratyphoid Fever

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Expression for genes affiliated with Paratyphoid Fever

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Search GEO for disease gene expression data for Paratyphoid Fever.

Pathways for genes affiliated with Paratyphoid Fever

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Pathways related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show all 39)
idSuper pathwaysScoreTop Affiliating Genes
19.6IFNGR1, IL12B
2
Show member pathways
9.5IFNGR1, TNFRSF1A
39.4IL1R1, TNFRSF1A
49.3IFNGR1, IL1B
5
Show member pathways
9.2IL1B, IL1R1
69.2IL1B, IL1R1
79.1CASP1, IL1B
89.1CASP1, IL1B
99.1IL12B, IL1B
109.1IL12B, IL1B
119.1IL12B, IL1B
12
Show member pathways
9.0IFNGR1, IL12B, TNFRSF1A
13
Show member pathways
8.9CASP1, IL1R1, TNFRSF1A
14
Show member pathways
8.9IFNGR1, IL1B, IL1R1
15
Show member pathways
8.9IFNGR1, IL1B, IL1R1
16
Show member pathways
8.8CASP1, IFNGR1, IL1B
17
Show member pathways
8.8IFNGR1, IL12B, IL1B
18
Show member pathways
8.7CASP1, IL1B, IL1R1
19
Show member pathways
8.7IL12B, IL1B, IL1R1
208.7IL12B, IL1B, IL1R1
21
Show member pathways
8.7IL12B, IL1B, IL1R1
228.6IL1B, IL1R1, TNFRSF1A
23
Show member pathways
8.6IL1B, IL1R1, TNFRSF1A
248.6CASP1, IL12B, IL1B
258.6CASP1, IL12B, IL1B
26
Show member pathways
8.2IFNGR1, IL1B, IL1R1, TNFRSF1A
278.2IFNGR1, IL1B, IL1R1, TNFRSF1A
28
Show member pathways
8.2IFNGR1, IL1B, IL1R1, TNFRSF1A
29
Show member pathways
8.1IFNGR1, IL12B, IL1B, TNFRSF1A
30
Show member pathways
8.1IFNGR1, IL12B, IL1B, TNFRSF1A
318.1IFNGR1, IL12B, IL1B, TNFRSF1A
328.1CASP1, IL1B, IL1R1, TNFRSF1A
33
Show member pathways
7.7IFNGR1, IL12B, IL1B, IL1R1, TNFRSF1A
34
Show member pathways
7.6CASP1, IFNGR1, IL12B, IL1B, TNFRSF1A
35
Show member pathways
7.6CASP1, IL12B, IL1B, IL1R1, TNFRSF1A
36
Show member pathways
7.6CASP1, IL12B, IL1B, IL1R1, TNFRSF1A
37
Show member pathways
7.2CASP1, IFNGR1, IL12B, IL1B, IL1R1, TNFRSF1A
38
Show member pathways
7.2CASP1, IFNGR1, IL12B, IL1B, IL1R1, TNFRSF1A
39
Show member pathways
6.7CASP1, IFNGR1, IL12B, IL1B, IL1R1, PARK2

GO Terms for genes affiliated with Paratyphoid Fever

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Biological processes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1regulation of inflammatory responseGO:005072710.1CASP1, IL1R1
2regulation of autophagyGO:001050610.1CASP1, PARK2
3positive regulation of inflammatory responseGO:005072910.0IL12B, TNFRSF1A
4cellular response to glucose stimulusGO:00713339.9IL1B, IL1R1
5ovulationGO:00307289.9IL1B, IL1R1
6cellular response to organic substanceGO:00713109.8CASP1, IL1B
7interleukin-1 beta productionGO:00326119.8CASP1, IL1B
8positive regulation of granulocyte macrophage colony-stimulating factor productionGO:00327259.8IL12B, IL1B
9positive regulation of interferon-gamma productionGO:00327299.8IL12B, IL1B
10positive regulation of NF-kappaB import into nucleusGO:00423469.8IL12B, IL1B
11positive regulation of T cell proliferationGO:00421029.8IL12B, IL1B
12response to ATPGO:00331989.7CASP1, IL1B
13regulation of establishment of endothelial barrierGO:19031409.6IL1B, TNFRSF1A
14cell surface receptor signaling pathwayGO:00071669.6IL12B, IL1R1, TNFRSF1A
15cellular response to mechanical stimulusGO:00712609.2CASP1, IL1B, TNFRSF1A
16cytokine-mediated signaling pathwayGO:00192218.8IL12B, IL1B, IL1R1, TNFRSF1A
17positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431238.7CASP1, IL1B, PARK2, TNFRSF1A
18response to lipopolysaccharideGO:00324968.5CASP1, IL1B, TNFRSF1A

Sources for Paratyphoid Fever

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet