MCID: PRT002
MIFTS: 62

Paratyphoid Fever malady

Infectious diseases category

Summaries for Paratyphoid Fever

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection located in intestine, has material basis in salmonella enterica subsp enterica serovar paratyphi a, b or c, which are transmitted by ingestion of contaminated food. the infection has symptom fever, has symptom headache, has symptom abdominal pain, has symptom malaise, has symptom anorexia, has symptom constipation, has symptom rosy spots on the central body, has symptom non productive cough (in early stage of illness), has symptom bradycardia, and has symptom hepatosplenomegaly.

MalaCards: Paratyphoid Fever, also known as paratyphoid b fever, is related to typhoid fever and appendicitis, and has symptoms including hepatosplenomegaly, bradycardia and non productive cough (in early stage of illness). An important gene associated with Paratyphoid Fever is IFNGR1 (interferon gamma receptor 1), and among its related pathways are Th17 Differentiation and Senescence and Autophagy. The compounds amphotericin b and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include intestine, testes and bone, and related mouse phenotypes are integument and tumorigenesis.

Wikipedia:63 Paratyphoid fevers are a group of enteric illnesses caused by serotypic strains of the Salmonella genus... more...

Aliases & Classifications for Paratyphoid Fever

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

paratyphoid fever 8 10 60
paratyphoid b fever 8 60
paratyphoid c fever 8 60
paratyphoid fever a 8
paratyphoid a fever 8
paratyphoid fever c 8
paratyphoid fever b 8
paratyphoid b 8
paratyphoid a 8
paratyphoid c 8
paratyphoid 8


Related Diseases for Paratyphoid Fever

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17GeneCards, 18GeneDecks
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Diseases related to Paratyphoid Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1typhoid fever31.5IFNGR1, HIST1H1D
2appendicitis30.1CRP
3vasculitis30.1CRP
4aortic aneurysm29.9CRP
5rare form of salmonellosis10.6
6dysentery10.3
7relapsing fever10.3
8biliary atresia10.1
9duodenitis10.1
10nephrotic syndrome10.1
11purpura10.1
12spotted fever10.1
13urticaria10.0CASP1
14diabetic retinopathy10.0CASP1
15hodgkin's lymphoma10.0HDAC11
16campylobacteriosis10.0SUMF2
17neutropenia10.0TNFRSF1A
18schnitzler syndrome10.0IL1R1
19common variable immune deficiency10.0TNFRSF1A
20down syndrome10.0CASP1
21infertility10.0CASP1
22hepatocellular carcinoma10.0CASP1
23pancreatic cancer10.0CASP1
24measles10.0IL12B, HIST1H1A
25polymyalgia rheumatica10.0CRP
26paracoccidioidomycosis10.0TNFRSF1A
27dermatomyositis10.0IL1A
28silicosis10.0IL1A
29crohn's disease10.0CRP
30rheumatic disease10.0CRP
31pemphigus vulgaris10.0IL1A
32ulcerative colitis10.0CRP
33deficiency anemia10.0CRP
34viral hepatitis10.0TNFRSF1A
35rheumatic fever10.0CRP
36mycobacterium avium complex disease10.0IFNGR1
37myeloid leukemia10.0CASP1
38acute myocardial infarction10.0CRP
39hypercalcemia10.0IL1A
40hyperglycemia10.0CRP
41insulinoma10.0CASP1
42herpes simplex10.0CASP1, IL12B
43kawasaki disease10.0CRP
44pulmonary fibrosis10.0IL1B
45systemic lupus erythematosus10.0CRP
46polymyositis10.0IL1A
47interstitial lung disease10.0IL1B
48coronary heart disease10.0CRP
49obesity10.0CRP
50acquired immunodeficiency syndrome10.0IL1B

Graphical network of the top 20 diseases related to Paratyphoid Fever:



Diseases related to paratyphoid fever

Clinical Features for Paratyphoid Fever

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8Disease Ontology
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Symptoms:

8 (show all 10)
  • hepatosplenomegaly
  • bradycardia
  • non productive cough (in early stage of illness)
  • rosy spots on the central body
  • constipation
  • anorexia
  • malaise
  • abdominal pain
  • headache
  • fever

Drugs & Therapeutics for Paratyphoid Fever

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Paratyphoid Fever

Drug clinical trials:

Search ClinicalTrials for Paratyphoid Fever

Search NIH Clinical Center for Paratyphoid Fever

Search CenterWatch for Paratyphoid Fever

Genetic Tests for Paratyphoid Fever

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Anatomical Context for Paratyphoid Fever

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Paratyphoid Fever:

32
Testes, Bone, Bone marrow

FMA organs/tissues related to Paratyphoid Fever:

14
Intestine

Animal Models for Paratyphoid Fever or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Paratyphoid Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.3CASP1, OGN, CTSC, IL1R1
2MP:00020069.2CASP1, IFNG, IFNGR1, TNFRSF1A, IL12B, IL1R1
3MP:00053679.1IL1R1, CXCL14, TNFRSF1A, IFNGR1, IFNG, CASP1
4MP:00053858.5CASP1, IFNG, IFNGR1, TNFRSF1A, CRP, HIST1H1D
5MP:00053978.3CASP1, IFNG, IFNGR1, TNFRSF1A, HIST1H1D, CXCL14
6MP:00053877.9IL1B, CASP1, IFNG, IFNGR1, TNFRSF1A, CTSC
7MP:00053767.8CASP1, OGN, IFNG, IFNGR1, TNFRSF1A, CTSC

Publications for Paratyphoid Fever

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50PubMed
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Articles related to Paratyphoid Fever:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (21975746)
2011
2
Typhoid and paratyphoid fever - prevention in travellers. (21301658)
2010
3
Yields from blood cultures of patients with suspected paratyphoid fever A. (24031492)
2010
4
Global trends in typhoid and paratyphoid Fever. (20014951)
2010
5
Study on blood cultures and bacteria counts in the blood of paratyphoid fever A patients. (19526258)
2009
6
Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever. (17477815)
2007
7
Ty21a live oral typhoid vaccine and prevention of paratyphoid fever caused by Salmonella enterica Serovar Paratyphi B. (17582564)
2007
8
Typhoid and paratyphoid fever. (16125594)
2005
9
Paratyphoid fever in Vellore, South India. (16105360)
2005
10
Epidemiology of typhoid and paratyphoid fever in Kathmandu: two years study and trends of antimicrobial resistance. (16082406)
2005
11
LipschA1tz genital ulceration: a rare manifestation of paratyphoid fever. (12804994)
2003
12
Oral administration of fluoroquinolones in the treatment of typhoid fever and paratyphoid fever in Japan. (11197787)
2000
13
Paratyphoid fever in India: An emerging problem. (10341194)
1999
14
Paratyphoid fever due to Salmonella enterica serotype Paratyphi A. (9284393)
1997
15
A relapse of paratyphoid fever after treatment with ciprofloxacin in a child with congenital biliary atresia. (9183498)
1997
16
Typhoid and paratyphoid fever: a retrospective study. (1413100)
1992
17
Paratyphoid fever: analysis of 18 cases and its unusual complications. (3146430)
1988
18
Typhoid and paratyphoid fever in 192 hospitalized children in Thailand. (3115088)
1987
19
Paratyphoid fever presenting with grand mal fits and cerebellar signs. (3920327)
1985
20
Paratyphoid fever in England and Wales, 1978-82. (6416417)
1983
21
Prevention of development of carriers in typhoid and paratyphoid fever. (4196796)
1973
22
Influence of chloramphenicol and ampicillin on antibody response in typhoid-paratyphoid fever. (4984110)
1970
23
A comparative trial of furazolidone and chloramphenicol in typhoid and paratyphoid fever. (4995053)
1970
24
Treatment of typhoid and paratyphoid fever with nalidixic acid. (4987433)
1970
25
Epidemiological investigations of typhoid and paratyphoid fever in Japan with aid of the phage typing method. I. Distribution of phage-types of salmonella typhi and salmonella paratyphi b in Japan, 1956-1965. (4968085)
1967
26
COMPARISON OF AMPICILLIN AND CHLORAMPHENICOL IN TREATMENT OF PARATYPHOID FEVER. (14072634)
1964
27
AMPICILLIN IN THE TREATMENT OF PARATYPHOID FEVER--A COMPARATIVE TRIAL. (14246856)
1964
28
PATHOGENESIS OF RECURRENCE OF PARATYPHOID FEVER AFTER ANTIBIOTIC THERAPY. (14196944)
1964
29
Transport in the tropics of faecal samples for bacteriological examination for typhoid and paratyphoid fever and bacillary dysentery. (13753960)
1960
30
Acute ileitis with ulceration and perforation due to paratyphoid fever; report of eighty-five cases. (13399825)
1957
31
Typhoid and paratyphoid fever; report of six cases with one death. (13361260)
1956
32
Second attack of paratyphoid fever. (13276681)
1956
33
Some Important Lessons from the Lancaster, Pennsylvania, Paratyphoid Fever Epidemic. (18017556)
1956
34
Paratyphoid fever and bakers' confectionery; an analysis of an epidemic in South Wales, 1952. (13099191)
1953
35
Paratyphoid fever; a case report. (14874678)
1951
36
Chloromycetin in typhoid and paratyphoid fever. (14794145)
1950
37
A small outbreak of paratyphoid fever. (15393118)
1949
38
Field investigation of paratyphoid fever with typing of Salm. paratyphi B by means of Vi bacteriophage. (20262099)
1947
39
3 cases of skeletal changes round the knee joint in paratyphoid fever in infants. (20985426)
1946
40
Paratyphoid fever simulating acute appendicitis. (20275908)
1946
41
Observations on an epidemic of paratyphoid fever in Dundee, 1941. (20475679)
1944
42
Paratyphoid fever: an epidemiological study. (20475641)
1942
43
TWO CASES OF HAEMORRHAGIC PARATYPHOID FEVER. (20776232)
1931
44
Relationship of Paratyphoid Fever to Food Poisoning Outbreaks. (20474853)
1925
45
DISCUSSION ON PARATYPHOID FEVER. (19979279)
1916
46
Discussion on Paratyphoid Fever. (19979284)
1916
47
Discussion on Paratyphoid Fever. (19979285)
1916
48
Discussion on Paratyphoid Fever. (19979282)
1916
49
Discussion on Paratyphoid Fever. (19979287)
1916
50
A Note on Paratyphoid Fever from the Public Health Standpoint. (19599793)
1903

Genetic Variations for Paratyphoid Fever

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Expression for genes affiliated with Paratyphoid Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paratyphoid Fever

Search GEO for disease gene expression data for Paratyphoid Fever.

Pathways for genes affiliated with Paratyphoid Fever

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Sources:
52R&D Systems, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN, 59Tocris Bioscience
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Pathways related to Paratyphoid Fever according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3IL1R1
210.1CXCL14
310.1IFNG, IFNGR1
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.0IFNG, IL1A
5
Hide members
9.9IL1A, IL12B, IFNGR1
6
Apoptosis and survival Caspase cascade
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9.9CASP1, TNFRSF1A, IL1A
79.9CASP1, IL1B, IL12B
89.9IL1A, IL1R1, TNFRSF1A
9
Hide members
9.9TNFRSF1A, IFNG, IFNGR1
109.9IL1R1, TNFRSF1A, IL1B
119.8IL1B, IL1A, CASP1
129.8IL1A, IL1B, IL1R1
139.8IL1A, IL1B, IL1R1
14
Hide members
9.8IL1A, IL1B, IL1R1
15
Hide members
9.8IL1R1, IL1A, IL1B
16
Hide members
9.8OGN, TNFRSF1A, IL12B
179.8IL1B, IFNG, IFNGR1
189.8IFNG, IL1B, IL12B
199.8IL12B, IL1B, IFNG
209.8IFNG, CRP, IL1B
219.7CASP1, IL1B, IL12B, IL1A
22
Hide members
9.6IL1R1, CASP1, IL1B, IL1A
23
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9.6IL1A, IL1B, CASP1, IL1R1
24
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9.6OGN, IL12B, CXCL14
25
Hide members
9.6IFNGR1, IL12B, IL1B, IFNG
26
Immune response IFN gamma signaling pathway
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9.6IFNGR1, CASP1, IFNG, IL1B
279.6IL12B, IFNG, IL1R1, IL1B
28
Hide members
9.6IFNG, IL12B, IL1B, IL1R1
299.6IL1B, IL1A, IFNG, IL12B
309.6IL1B, IL12B, IFNG, IL1A
31
Hide members
9.5IL1R1, CASP1, TNFRSF1A, IL1A, IL1B
32
Hide members
9.5TNFRSF1A, CASP1, IL1R1, IL1A, IL1B
33
Hide members
9.4IL12B, TNFRSF1A, IFNGR1, IL1B, IFNG
349.4CASP1, IFNG, IFNGR1, IL1A, IL1B
35
Hide members
9.4IL1B, IL1A, IL1R1, IFNGR1, IFNG
36
Immune response Bacterial infections in normal airways
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9.4IFNGR1, IL1B, IL1A, IFNG, IL1R1
37
Hide members
9.4IL1R1, IL1A, IL1B, TNFRSF1A, OGN
38
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9.3IL1B, CASP1, TNFRSF1A, IL12B, IL1R1, IL1A
39
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9.3TNFRSF1A, CXCL14, IL12B, IL1R1, OGN
40
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9.2IFNGR1, IL1A, IL1R1, IFNG, IL1B, CASP1
41
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9.2IFNG, HIST1H1D, CASP1, HIST1H1A, TNFRSF1A
42
Hide members
9.2IL1A, IL12B, TNFRSF1A, IFNGR1, IFNG, IL1B
439.2IL1B, TNFRSF1A, IFNGR1, IL12B, IFNG, IL1A
44
Hide members
9.2TNFRSF1A, IL1R1, IL1B, IFNGR1, IL1A, IFNG
459.2IFNG, IFNGR1, TNFRSF1A, IL1R1, IL1A, IL1B
46
Hide members
9.0IL12B, IL1B, IL1A, TNFRSF1A, IFNGR1, CASP1
47
Hide members
9.0CTSC, IL1A, IFNGR1, IL1B, CASP1, IL1R1
48
Hide members
8.9CXCL14, CASP1, IFNGR1, TNFRSF1A, HDAC11, IL1A
49
Hide members
8.8OGN, IL1A, IL1B, IL1R1, IL12B, CXCL14

Compounds for genes affiliated with Paratyphoid Fever

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Paratyphoid Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1amphotericin b4410.6IL1R1
2indomethacin44 59 28 1113.6IL1R1
3endotoxin4410.6CASP1, TNFRSF1A
4tenidap44 2811.5IL1R1, IL1A
5pirfenidone44 5911.4IL1B, IL1A
6pentoxifylline44 1111.4IL12B, IL1R1, CASP1
7gm-csf44 2811.3IFNG
8acetyl-tyr-val-ala-asp-cho4410.3CASP1, IL1B
9nh4cl4410.3CTSC, TNFRSF1A
10git 275910.2IL1A, IL1B, IL1R1
114-ipp5910.2IL1B, IL1A, IL1R1
12bucillamine4410.1CRP, IL1B, IFNG
13minocycline44 1111.1IL1A, CASP1, IL1B
14adalimumab44 49 1112.1IL1R1, IFNG, CRP
15auranofin44 59 28 1113.1IFNG, IL1A, IL1B
16imiquimod44 28 59 1113.1IL12B, IFNG, IL1A
17peptidoglycan44 2811.1IL1R1, CASP1, IL12B, IL1B
18staurosporin4410.1CASP1, IL1B, IFNG
19cuprophan4410.1CASP1, IL1R1, IL1B, TNFRSF1A
20anakinra44 1111.1IL1B, IL1R1, CRP, CASP1
21as 10159 4411.1IL1A, IL1R1, CASP1, IL1B
22polysulfone4410.1IL1B, IL1R1, CRP
23il-124410.0IL1B, IFNG, IL1R1, IL12B
24poly(i-c)4410.0IL12B, IL1B, IFNG, CASP1
25leflunomide49 44 1112.0TNFRSF1A, IL1B, IL1R1
26gold sodium thiomalate4410.0IFNG, IL1R1, IL1A, IL1B
27polyethylene glycol4410.0IL1R1, CRP, TNFRSF1A, IL1A
28polyinosinic-polycytidylic acid4410.0IFNG, IL1B, IL1A, IL12B
29okt34410.0IFNG, TNFRSF1A, CRP
30polymyxin b4410.0IL1A, IFNG, IL1B
31ccl344 2811.0IL1R1, IL1B, IL1A, IFNG
32lipoteichoic acid449.9IL1B, IL1R1, IL12B
33sulfasalazine44 28 49 1112.9IL1A, IL1R1, IL12B, CRP, IL1B
34il 10449.8IL12B, IL1B, IL1A, IL1R1, IFNG
35ns 39844 5910.8IL1B, IL1A, TNFRSF1A
36etanercept44 49 1111.8IL1B, CRP, TNFRSF1A, IFNG, IL1R1
37infliximab44 49 1111.8IL1B, IL1R1, CRP, IFNG, TNFRSF1A
38thalidomide44 49 59 1112.8IL1A, IL1B, IL1R1, TNFRSF1A, IFNG
39ribonucleic acid449.8IL1R1, IL1B, IL1A, TNFRSF1A, CASP1
40n acetylcysteine449.8TNFRSF1A, CRP, IL1R1, CASP1, IL1B
41rantes449.6IL1A, IL1B, IFNG, TNFRSF1A, IL12B, IL1R1
42ivig449.6IL1R1, CRP, TNFRSF1A, IFNG, IL1A, IL1B
43neopterin449.6IFNG, CRP, IL1R1, TNFRSF1A, IL1B, IL1A
44actinomycin d449.6IFNG, CASP1, TNFRSF1A, IL1B, IL1A, IL1R1
45simvastatin44 49 59 28 11 2414.6TNFRSF1A, IL1A, IFNG, CRP
46s-nitroso-n-acetylpenicillamine449.5IL1B, CASP1, IFNG
47herbimycin a44 5910.5IL1A, IL1B, TNFRSF1A, IFNG
48nitric oxide44 11 2411.4CASP1, TNFRSF1A, IL12B, IL1R1, IL1A, IFNG
49vegf449.3IFNG, IL1B, CASP1, TNFRSF1A, CRP, IL1R1
50sb 20358044 5910.2TNFRSF1A, IFNG, CRP, IL12B, IL1R1, IL1A

GO Terms for genes affiliated with Paratyphoid Fever

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16Gene Ontology
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Cellular components related to Paratyphoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.7OGN, IFNG, TNFRSF1A, CRP, IL1R1, IL1A
2extracellular spaceGO:0056158.2IL1B, OGN, IFNG, TNFRSF1A, CRP, CXCL14

Biological processes related to Paratyphoid Fever according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1interleukin-1 beta productionGO:03261110.3CASP1, IL1B
2fever generationGO:00166010.3IL1B, IL1A
3positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.3IL12B, IL1B
4positive regulation of calcidiol 1-monooxygenase activityGO:06055910.3IFNG, IL1B
5positive regulation of smooth muscle cell apoptotic processGO:03439310.3IL12B, IFNG
6negative regulation of interleukin-17 productionGO:03270010.2IFNG, IL12B
7positive regulation of interleukin-6 biosynthetic processGO:04541010.2IL1B, IFNG
8positive regulation of tumor necrosis factor productionGO:03276010.2IL12B, TNFRSF1A, IFNG
9positive regulation of chemokine biosynthetic processGO:04508010.2IFNG, IL1B
10positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.1TNFRSF1A, IFNG
11cellular response to mechanical stimulusGO:07126010.1IL1B, TNFRSF1A, CASP1
12negative regulation of smooth muscle cell proliferationGO:04866210.1OGN, IFNG, IL12B
13positive regulation of T cell proliferationGO:04210210.1IL1B, IL12B, IFNG
14positive regulation of interleukin-2 biosynthetic processGO:04508610.0IL1B, IL1A
15positive regulation of angiogenesisGO:0457669.9TNFRSF1A, IL1A, IL1B
16positive regulation of membrane protein ectodomain proteolysisGO:0510449.9IL1B, IFNG
17cytokine-mediated signaling pathwayGO:0192219.7IL1B, IL1A, TNFRSF1A, IFNGR1, IFNG
18immune responseGO:0069559.5IL1B, IL1A, IL1R1, CXCL14, CTSC
19apoptotic processGO:0069159.4IL1B, IL1A, TNFRSF1A, IFNG, CASP1
20inflammatory responseGO:0069549.3TNFRSF1A, CRP, IL1A, IL1B

Molecular functions related to Paratyphoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.0IL1B, IL1A
2cytokine activityGO:0051259.3IL1B, IL1A, IL12B, IFNG

Products for genes affiliated with Paratyphoid Fever

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  • Antibodies
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Sources for Paratyphoid Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet