MCID: PRT002
MIFTS: 57

Paratyphoid Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Paratyphoid Fever

MalaCards integrated aliases for Paratyphoid Fever:

Name: Paratyphoid Fever 12 72 55 41 14 69
Paratyphoid B Fever 12 69
Paratyphoid C Fever 12 69
Paratyphoid a Fever 12
Paratyphoid Fever a 12
Paratyphoid Fever B 12
Paratyphoid Fever C 12
Paratyphoid a 12
Paratyphoid B 12
Paratyphoid C 12
Paratyphoid 12

Characteristics:

Orphanet epidemiological data:

55
paratyphoid fever
Inheritance: Not applicable;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:3055
MeSH 41 D010284
Orphanet 55 ORPHA443227
UMLS via Orphanet 70 C0030528
ICD10 via Orphanet 33 A01.1 A01.2 A01.3 more

Summaries for Paratyphoid Fever

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection located in intestine, has material basis in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has symptom fever, has symptom headache, has symptom abdominal pain, has symptom malaise, has symptom anorexia, has symptom constipation, has symptom rosy spots on the central body, has symptom non productive cough (in early stage of illness), has symptom bradycardia, and has symptom hepatosplenomegaly.

MalaCards based summary : Paratyphoid Fever, also known as paratyphoid b fever, is related to typhoid fever and salmonellosis, and has symptoms including fever, headache and abdominal pain. An important gene associated with Paratyphoid Fever is IFNGR1 (Interferon Gamma Receptor 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Vaccines and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include intestine, skin and prostate, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 72 Paratyphoid fever, also known simply as paratyphoid, is a bacterial infection caused by one of the three... more...

Related Diseases for Paratyphoid Fever

Diseases related to Paratyphoid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 typhoid fever 31.9 CASP1 IFNGR1 TNF
2 salmonellosis 31.8 CASP1 IFNGR1
3 radiculopathy 10.2 IL1A IL1R1
4 cinca syndrome 10.2 CASP1 IL1R1
5 familial cold autoinflammatory syndrome 10.2 CASP1 IL1R1
6 wells syndrome 10.1 IL1R1 TNFRSF1A
7 dysentery 10.0
8 vulvar vestibulitis syndrome 10.0 IL1R1 TNF
9 cellulitis 10.0 IL1R1 TNF
10 streptococcal meningitis 10.0 IL1R1 TNF
11 aseptic meningitis 10.0 IL1R1 TNF
12 lepromatous leprosy 10.0 IFNGR1 TNF
13 joint disorders 10.0 IL1R1 TNF
14 pyoderma 10.0 IL1R1 TNF
15 periventricular leukomalacia 10.0 IL1R1 TNF
16 leukomalacia 10.0 IL1R1 TNF
17 adult-onset still's disease 10.0 IL1R1 TNF
18 skin conditions 9.9 IL1A TNF
19 irritant dermatitis 9.9 IL1A TNF
20 stachybotrys chartarum 9.9 IL1A TNF
21 multidrug-resistant tuberculosis 9.9 IL1A TNF
22 leprosy 3 9.9 PRKN TNF
23 malaria, mild 9.9
24 hepatitis 9.9
25 hepatitis b 9.9
26 ileitis 9.9
27 nephrotic syndrome 9.9
28 hepatitis a 9.9
29 biliary atresia 9.9
30 purpura 9.9
31 appendicitis 9.9
32 duodenitis 9.9
33 vasculitis 9.9
34 adult respiratory distress syndrome 9.9 IL1R1 TNF
35 lymphadenitis 9.9 IFNGR1 TNF
36 legionellosis 9.9 CASP1 TNF
37 keratoconjunctivitis sicca 9.8 IL1A TNF
38 chronic gonococcal salpingitis 9.8 TNF TNFRSF1A
39 retinitis pigmentosa 75 9.8 TNF TNFRSF1A
40 bacterial vaginosis 9.8 IL1A TNF
41 relapsing fever 9.8 TNF TNFRSF1A
42 dystrophinopathies 9.8 TNF TNFRSF1A
43 idiopathic neutropenia 9.8 IL1A TNF
44 periodic fever, familial, autosomal dominant 9.8 TNF TNFRSF1A
45 acute salpingitis 9.8 TNF TNFRSF1A
46 tonsillitis 9.8 IL1A TNF
47 chronic salpingitis 9.8 TNF TNFRSF1A
48 aggressive periodontitis 9.8 IL1A TNF
49 bacteremia 2 9.8
50 aortic aneurysm 9.8

Graphical network of the top 20 diseases related to Paratyphoid Fever:



Diseases related to Paratyphoid Fever

Symptoms & Phenotypes for Paratyphoid Fever

Symptoms:

12
  • fever
  • headache
  • abdominal pain
  • malaise
  • anorexia
  • constipation
  • rosy spots on the central body
  • non productive cough (in early stage of illness)
  • bradycardia
  • hepatosplenomegaly

GenomeRNAi Phenotypes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 TNF TNFRSF1A CASP1 IL1A PRKN
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 TNF TNFRSF1A CASP1 IL1A PRKN

MGI Mouse Phenotypes related to Paratyphoid Fever:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 TNF IL1A TNFRSF1A IL1R1 CASP1 PRKN
2 cellular MP:0005384 9.93 IFNGR1 TNF IL1R1 CASP1 PRKN TNFRSF1A
3 homeostasis/metabolism MP:0005376 9.91 IFNGR1 TNF IL1A TNFRSF1A IL1R1 CASP1
4 hematopoietic system MP:0005397 9.88 IFNGR1 TNF IL1A TNFRSF1A IL1R1 CASP1
5 endocrine/exocrine gland MP:0005379 9.83 IFNGR1 TNF IL1R1 CASP1 TNFRSF1A
6 immune system MP:0005387 9.8 IFNGR1 TNF IL1A IL1R1 CASP1 TNFRSF1A
7 integument MP:0010771 9.8 TNF IL1A TNFRSF1A IL1R1 CASP1 PRKN
8 neoplasm MP:0002006 9.63 TNF IL1A TNFRSF1A IL1R1 CASP1 IFNGR1
9 nervous system MP:0003631 9.43 IFNGR1 TNF IL1R1 CASP1 PRKN TNFRSF1A
10 skeleton MP:0005390 9.02 IFNGR1 TNF IL1R1 PRKN TNFRSF1A

Drugs & Therapeutics for Paratyphoid Fever

Drugs for Paratyphoid Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 1,Phase 2
2 Pharmaceutical Solutions Phase 1, Phase 2
3 Liver Extracts Phase 1, Phase 2
4 Lecithin Nutraceutical Phase 1, Phase 2
5 Soy Bean Nutraceutical Phase 1, Phase 2

Interventional clinical trials:

(show all 12)

# Name Status NCT ID Phase Drugs
1 Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China Completed NCT00131833 Phase 4
2 Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central Vietnam Completed NCT00131820 Phase 4
3 Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in Childhood Completed NCT00125047 Phase 4
4 Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever Completed NCT00125008 Phase 4
5 TY800 Dose Escalation (Typhoid) Completed NCT00269295 Phase 1, Phase 2 Placebo
6 Safety and Efficacy Study of Mix Vaccine in Prostate Carcinoma Patient Completed NCT02338700 Phase 1, Phase 2
7 Safety and Efficacy Study of Mix Vaccine in Breast Carcinoma Patient Completed NCT02338804 Phase 1, Phase 2
8 Safety and Efficacy Study of Mix Vaccine in Hepatocyte Carcinoma Patient Completed NCT02338778 Phase 1, Phase 2
9 Safety and Efficacy Study of Mix Vaccine in Pancreatic Carcinoma Patient Completed NCT02338752 Phase 1, Phase 2
10 Investigating Enteric Fever - Salmonella Typhi and Paratyphi Challenge Study Recruiting NCT02192008
11 Understanding Paratyphoid Infection Active, not recruiting NCT02100397
12 Investigating Typhoid Fever Pathogenesis Active, not recruiting NCT03067961

Search NIH Clinical Center for Paratyphoid Fever

Cochrane evidence based reviews: paratyphoid fever

Genetic Tests for Paratyphoid Fever

Anatomical Context for Paratyphoid Fever

The Foundational Model of Anatomy Ontology organs/tissues related to Paratyphoid Fever:

18
Intestine

MalaCards organs/tissues related to Paratyphoid Fever:

38
Skin, Prostate, Breast, Liver, Testes, Bone, Bone Marrow

Publications for Paratyphoid Fever

Articles related to Paratyphoid Fever:

(show top 50) (show all 134)
# Title Authors Year
1
Review of current typhoid fever vaccines, cross-protection against paratyphoid fever, and the European guidelines. ( 28856924 )
2017
2
Overview of the impact of Typhoid and Paratyphoid fever. Utility of Ty21a vaccine (VivotifAr). ( 28515625 )
2017
3
Six Cases of Paratyphoid Fever Due to Salmonella Paratyphi A in Travelers Returning from Myanmar Between July 2014 and August 2015. ( 27352874 )
2016
4
Status of paratyphoid fever vaccine research and development. ( 27083427 )
2016
5
A Large-Scale Community-Based Outbreak of Paratyphoid Fever Caused by Hospital-Derived Transmission in Southern China. ( 26186586 )
2015
6
Increase in paratyphoid fever cases in Japanese travellers returning from Cambodia in 2013. ( 26169980 )
2015
7
Paratyphoid fever: splicing the global analyses. ( 24904229 )
2014
8
Psychosis in paratyphoid fever - a case report from Australia. ( 24820292 )
2014
9
Typhoid and paratyphoid fever. ( 24707582 )
2014
10
Recurrent paratyphoid fever A co-infected with hepatitis A reactivated chronic hepatitis B. ( 24884719 )
2014
11
The application of the grey disaster model to forecast epidemic peaks of typhoid and paratyphoid fever in China. ( 23565260 )
2013
12
Correction: The Application of the Grey Disaster Model to Forecast Epidemic Peaks of Typhoid and Paratyphoid Fever in China. ( 24039655 )
2013
13
Spatiotemporal transmission and determinants of typhoid and paratyphoid fever in Hongta District, Yunnan Province, China. ( 23516653 )
2013
14
Typhoid fever and paratyphoid fever: Systematic review to estimate global morbidity and mortality for 2010. ( 23198130 )
2012
15
Typhoid and paratyphoid fever in Western Sydney Local Health District, NSW, January-June 2011. ( 23043747 )
2012
16
Association between the incidence of typhoid and paratyphoid fever and meteorological variables in Guizhou, China. ( 22490402 )
2012
17
Study of clinical profile and antibiotic sensitivity in paratyphoid Fever cases admitted at teaching hospital in South India. ( 24479019 )
2012
18
WITHDRAWN: Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever). ( 21975751 )
2011
19
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). ( 21975746 )
2011
20
Burden of typhoid and paratyphoid fever in a densely populated urban community, Dhaka, Bangladesh. ( 20236850 )
2010
21
Typhoid and paratyphoid fever - prevention in travellers. ( 21301658 )
2010
22
Global trends in typhoid and paratyphoid Fever. ( 20014951 )
2010
23
Yields from blood cultures of patients with suspected paratyphoid fever A. ( 24031492 )
2010
24
Study on blood cultures and bacteria counts in the blood of paratyphoid fever A patients. ( 19526258 )
2009
25
Epidemiology of typhoid and paratyphoid fever hospitalizations in Spain (1997-2005). ( 19276655 )
2009
26
Laboratory-based surveillance of paratyphoid fever in the United States: travel and antimicrobial resistance. ( 18422453 )
2008
27
Epidemiology of typhoid and paratyphoid fever in India. ( 19745523 )
2008
28
Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever). ( 18843701 )
2008
29
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). ( 18843659 )
2008
30
Ty21a live oral typhoid vaccine and prevention of paratyphoid fever caused by Salmonella enterica Serovar Paratyphi B. ( 17582564 )
2007
31
Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever. ( 17477815 )
2007
32
Comparisons of predictors for typhoid and paratyphoid fever in Kolkata, India. ( 17935611 )
2007
33
PARK2/PACRG polymorphisms and susceptibility to typhoid and paratyphoid fever. ( 16734611 )
2006
34
Deep-seated resistance in relapsed paratyphoid fever. ( 16652303 )
2006
35
Typhoid and paratyphoid fever. ( 16271636 )
2005
36
Epidemiology of typhoid and paratyphoid fever in Kathmandu: two years study and trends of antimicrobial resistance. ( 16082406 )
2005
37
Typhoid and paratyphoid fever. ( 16125594 )
2005
38
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). ( 15846718 )
2005
39
Typhoid and paratyphoid fever in travellers. ( 16183516 )
2005
40
Typhoid and paratyphoid fever. ( 16271635 )
2005
41
Identification of typhoid fever and paratyphoid fever cases at presentation in outpatient clinics in Jakarta, Indonesia. ( 15837356 )
2005
42
Paratyphoid fever in Vellore, South India. ( 16105360 )
2005
43
Risk factors for typhoid and paratyphoid fever in Jakarta, Indonesia. ( 15173152 )
2004
44
LipschA1tz genital ulceration: a rare manifestation of paratyphoid fever. ( 12804994 )
2003
45
An unusual paratyphoid fever. ( 11762624 )
2001
46
Typhoid and paratyphoid fever: a 10-year retrospective study of 41 cases in a Parisian hospital. ( 11726293 )
2001
47
Oral administration of fluoroquinolones in the treatment of typhoid fever and paratyphoid fever in Japan. ( 11197787 )
2000
48
Typhoid and paratyphoid fever in south-eastern Sydney, 1992-1997. ( 11022389 )
2000
49
Epidemiological studies of an outbreak of paratyphoid fever in the Shima area of Mie Prefecture. ( 10738368 )
1999
50
Paratyphoid fever in India: An emerging problem. ( 10341194 )
1999

Variations for Paratyphoid Fever

Expression for Paratyphoid Fever

Search GEO for disease gene expression data for Paratyphoid Fever.

Pathways for Paratyphoid Fever

Pathways related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 CASP1 IFNGR1 IL1A IL1R1 PRKN TNF
2
Show member pathways
13.42 CASP1 IFNGR1 IL1A IL1R1 TNF TNFRSF1A
3
Show member pathways
13.32 IFNGR1 IL1A IL1R1 TNF TNFRSF1A
4
Show member pathways
13.11 CASP1 IL1A IL1R1 TNF TNFRSF1A
5
Show member pathways
13.11 CASP1 IFNGR1 IL1A IL1R1 TNF TNFRSF1A
6
Show member pathways
13.02 IFNGR1 IL1A IL1R1 TNF TNFRSF1A
7
Show member pathways
12.8 CASP1 IL1A IL1R1 TNF
8
Show member pathways
12.65 CASP1 IL1R1 TNF TNFRSF1A
9
Show member pathways
12.55 CASP1 IFNGR1 IL1A TNF TNFRSF1A
10
Show member pathways
12.54 IL1A IL1R1 TNF TNFRSF1A
11 12.49 CASP1 IL1A IL1R1 TNF TNFRSF1A
12
Show member pathways
12.45 IFNGR1 TNF TNFRSF1A
13
Show member pathways
12.41 IFNGR1 TNF TNFRSF1A
14
Show member pathways
12.41 IFNGR1 IL1A IL1R1 TNF
15
Show member pathways
12.38 IFNGR1 TNF TNFRSF1A
16
Show member pathways
12.34 CASP1 TNF TNFRSF1A
17
Show member pathways
12.33 CASP1 IL1A IL1R1 TNF TNFRSF1A
18
Show member pathways
12.32 IFNGR1 IL1A IL1R1 TNF TNFRSF1A
19 12.27 IL1R1 TNF TNFRSF1A
20
Show member pathways
12.16 CASP1 IL1A IL1R1
21 12.11 CASP1 TNF TNFRSF1A
22
Show member pathways
12.1 CASP1 IL1A TNF TNFRSF1A
23
Show member pathways
12.08 IFNGR1 IL1A TNF TNFRSF1A
24
Show member pathways
12.07 IFNGR1 IL1A IL1R1 TNF
25
Show member pathways
12.05 IFNGR1 IL1R1 TNF
26 12.05 IFNGR1 TNF TNFRSF1A
27 12.05 IFNGR1 IL1A TNF TNFRSF1A
28
Show member pathways
11.91 CASP1 TNF TNFRSF1A
29 11.89 IL1A IL1R1 TNF
30
Show member pathways
11.86 CASP1 TNF TNFRSF1A
31 11.81 IL1A IL1R1 TNF TNFRSF1A
32 11.77 IL1A IL1R1 TNF
33 11.75 IL1R1 TNF TNFRSF1A
34
Show member pathways
11.71 CASP1 IFNGR1
35 11.69 CASP1 IFNGR1 IL1A
36 11.62 CASP1 IL1A TNF
37
Show member pathways
11.6 CASP1 IFNGR1 IL1A TNF TNFRSF1A
38 11.54 TNF TNFRSF1A
39
Show member pathways
11.53 IL1A TNF TNFRSF1A
40 11.46 CASP1 TNF
41 11.42 TNF TNFRSF1A
42
Show member pathways
11.42 IFNGR1 TNF TNFRSF1A
43 11.36 IL1A TNF
44 11.35 TNF TNFRSF1A
45 11.35 TNF TNFRSF1A
46
Show member pathways
11.34 IL1R1 TNF
47 11.29 IL1A IL1R1 TNF TNFRSF1A
48
Show member pathways
11.25 TNF TNFRSF1A
49 11.24 IL1A TNF
50 11.19 TNF TNFRSF1A

GO Terms for Paratyphoid Fever

Biological processes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.88 IL1A PRKN TNF TNFRSF1A
2 inflammatory response GO:0006954 9.79 IL1A TNF TNFRSF1A
3 positive regulation of gene expression GO:0010628 9.79 IL1A PRKN TNF
4 immune response GO:0006955 9.76 IL1A IL1R1 TNF TNFRSF1A
5 cytokine-mediated signaling pathway GO:0019221 9.65 IL1A IL1R1 TNFRSF1A
6 positive regulation of protein catabolic process GO:0045732 9.61 PRKN TNF
7 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.6 TNF TNFRSF1A
8 regulation of autophagy GO:0010506 9.59 CASP1 PRKN
9 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.58 TNF TNFRSF1A
10 positive regulation of interleukin-6 production GO:0032755 9.57 IL1A TNF
11 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.56 CASP1 TNF
12 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.55 IL1A TNF
13 regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 9.54 TNF TNFRSF1A
14 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.52 TNF TNFRSF1A
15 regulation of reactive oxygen species metabolic process GO:2000377 9.51 PRKN TNF
16 interleukin-1-mediated signaling pathway GO:0070498 9.49 IL1A IL1R1
17 positive regulation of ceramide biosynthetic process GO:2000304 9.43 TNF TNFRSF1A
18 regulation of inflammatory response GO:0050727 9.43 CASP1 IL1R1 TNF
19 death-inducing signaling complex assembly GO:0071550 9.4 TNF TNFRSF1A
20 positive regulation of tumor necrosis factor-mediated signaling pathway GO:1903265 9.37 CASP1 PRKN
21 regulation of establishment of endothelial barrier GO:1903140 9.32 TNF TNFRSF1A
22 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.26 CASP1 PRKN TNF TNFRSF1A
23 positive regulation of neutrophil extravasation GO:2000391 9.16 IL1A IL1R1
24 positive regulation of cytokine secretion GO:0050715 8.8 CASP1 IL1A TNF

Sources for Paratyphoid Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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