MCID: PRT002
MIFTS: 47

Paratyphoid Fever malady

Infectious diseases, Gastrointestinal diseases categories

Aliases & Classifications for Paratyphoid Fever

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Aliases & Descriptions for Paratyphoid Fever:

Name: Paratyphoid Fever 10 12 65 36
Paratyphoid C Fever 10 65
Paratyphoid B Fever 10 65
Paratyphoid Fever a 10
Paratyphoid a Fever 10
Paratyphoid Fever B 10
 
Paratyphoid Fever C 10
Paratyphoid B 10
Paratyphoid a 10
Paratyphoid C 10
Paratyphoid 10


Classifications:



Summaries for Paratyphoid Fever

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Disease Ontology:10 A primary bacterial infectious disease that results in infection located in intestine, has material basis in salmonella enterica subsp enterica serovar paratyphi a, b or c, which are transmitted by ingestion of contaminated food. the infection has symptom fever, has symptom headache, has symptom abdominal pain, has symptom malaise, has symptom anorexia, has symptom constipation, has symptom rosy spots on the central body, has symptom non productive cough (in early stage of illness), has symptom bradycardia, and has symptom hepatosplenomegaly.

MalaCards based summary: Paratyphoid Fever, also known as paratyphoid c fever, is related to typhoid fever and dysentery, and has symptoms including fever, headache and abdominal pain. An important gene associated with Paratyphoid Fever is IFNGR1 (Interferon Gamma Receptor 1), and among its related pathways are Hypertrophy Model and Cellular Transformation by HTLV1. Affiliated tissues include intestine, bone and testes, and related mouse phenotypes are integument and skeleton.

Related Diseases for Paratyphoid Fever

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Diseases related to Paratyphoid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1typhoid fever10.6
2dysentery10.3
3hepatitis10.2
4hepatitis b10.2
5biliary atresia10.2
6hepatitis a10.2
7appendicitis10.2
8duodenitis10.2
9ileitis10.2
10nephrotic syndrome10.2
11purpura10.2
12vasculitis10.2
13idiopathic neutropenia10.2IL1A, IL1R1
14optic nerve sheath meningioma10.2IL1A, IL1R1
15glycogen storage disease viii10.1IFNGR1, TNF
16bacteremia10.1
17aortic aneurysm10.1
18aneurysm10.1
19diffuse cutaneous mastocytosis10.1IL1A, IL1R1
20t cell immunodeficiency primary10.1IL1R1, TNF
21central epithelioid sarcoma10.1IL1R1, TNF
22intermediate dend syndrome10.1IL1R1, TNF
23pyrimidine metabolic disorder10.1IL1R1, TNF
24petrositis10.1IL1R1, TNF
25herpangina10.1IFNGR1, TNF
26extraskeletal chondroma10.1IL1R1, TNF
27skin disease10.1IL1A, TNF
28leukomelanoderma mental redardation hypotrichosis10.1IL1R1, TNF
29fibroepithelial polyp of the anus10.1IL1A, TNF
30second-degree atrioventricular block10.1IL1A, TNF
31alopecia universalis10.1IL1A, TNF
32leiomyoma10.0CASP1, TNF
33splenic manifestation of prolymphocytic leukemia10.0CASP1, IL1B
34familial mediterranean fever, ar10.0
35splenic infarction10.0
36orchitis10.0
37intestinal perforation10.0
38primary bacterial infectious disease10.0
39extrinsic allergic alveolitis10.0IFNGR1, IL1B
40diabetic cataract10.0IL1A, IL1B
41wells-jankovic syndrome10.0IL1B, IL1R1
42ischemia10.0IL1A, IL1B
43liver cirrhosis10.0IL1A, IL1B
44meningoencephalocele10.0IL1A, IL1B
45methylmalonic aciduria and homocystinuria type cble10.0IL1A, IL1B
46meckel's diverticulitis10.0IL1B, TNF
47stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features10.0IL1B, TNF
48peyronie's disease10.0IL1B, TNF
49plantar nerve lesion10.0IL1B, TNF
50larynx sarcoma10.0IL1B, TNF

Graphical network of the top 20 diseases related to Paratyphoid Fever:



Diseases related to paratyphoid fever

Symptoms for Paratyphoid Fever

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Symptoms:

 10 (show all 10)
  • fever
  • headache
  • abdominal pain
  • malaise
  • anorexia
  • constipation
  • rosy spots on the central body
  • non productive cough (in early stage of illness)
  • bradycardia
  • hepatosplenomegaly

Drugs & Therapeutics for Paratyphoid Fever

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Drugs for Paratyphoid Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Soy BeanNutraceuticalPhase 1, Phase 2427
2LecithinNutraceuticalPhase 1, Phase 257

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Evaluation of the Vi Polysaccharide Vaccine Against Typhoid FeverCompletedNCT00125008Phase 4
2Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central VietnamCompletedNCT00131820Phase 4
3Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, ChinaCompletedNCT00131833Phase 4
4Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in ChildhoodCompletedNCT00125047Phase 4
5TY800 Dose Escalation (Typhoid)CompletedNCT00269295Phase 1, Phase 2
6Safety and Efficacy Study of Mix Vaccine in Prostate Carcinoma PatientCompletedNCT02338700Phase 1, Phase 2
7Safety and Efficacy Study of Mix Vaccine in Breast Carcinoma PatientCompletedNCT02338804Phase 1, Phase 2
8Safety and Efficacy Study of Mix Vaccine in Hepatocyte Carcinoma PatientCompletedNCT02338778Phase 1, Phase 2
9Safety and Efficacy Study of Mix Vaccine in Pancreatic Carcinoma PatientCompletedNCT02338752Phase 1, Phase 2
10Investigating Enteric Fever - Salmonella Typhi and Paratyphi Challenge StudyRecruitingNCT02192008
11Understanding Paratyphoid InfectionActive, not recruitingNCT02100397

Search NIH Clinical Center for Paratyphoid Fever


Cochrane evidence based reviews: Paratyphoid Fever

Genetic Tests for Paratyphoid Fever

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Anatomical Context for Paratyphoid Fever

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MalaCards organs/tissues related to Paratyphoid Fever:

33
Bone, Testes, Bone marrow

FMA organs/tissues related to Paratyphoid Fever:

16
Intestine

Animal Models for Paratyphoid Fever or affiliated genes

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MGI Mouse Phenotypes related to Paratyphoid Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.3CASP1, IFNGR1, IL1R1, PARK2, TNF
2MP:00053908.1IFNGR1, IL1B, IL1R1, PARK2, TNF
3MP:00020067.4CASP1, IFNGR1, IL1A, IL1B, IL1R1, TNF
4MP:00036317.4CASP1, IFNGR1, IL1B, IL1R1, PARK2, TNF
5MP:00053877.3CASP1, IFNGR1, IL1A, IL1B, IL1R1, TNF
6MP:00053977.2CASP1, IFNGR1, IL1A, IL1B, IL1R1, TNF
7MP:00053857.0CASP1, IFNGR1, IL1A, IL1B, IL1R1, PARK2
8MP:00053766.8CASP1, IFNGR1, IL1A, IL1B, IL1R1, PARK2

Publications for Paratyphoid Fever

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Articles related to Paratyphoid Fever:

(show top 50)    (show all 130)
idTitleAuthorsYear
1
Psychosis in paratyphoid fever - a case report from Australia. (24820292)
2014
2
Correction: The Application of the Grey Disaster Model to Forecast Epidemic Peaks of Typhoid and Paratyphoid Fever in China. (24039655)
2013
3
Typhoid and paratyphoid fever in Western Sydney Local Health District, NSW, January-June 2011. (23043747)
2012
4
Association between the incidence of typhoid and paratyphoid fever and meteorological variables in Guizhou, China. (22490402)
2012
5
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (21975746)
2011
6
Burden of typhoid and paratyphoid fever in a densely populated urban community, Dhaka, Bangladesh. (20236850)
2010
7
Typhoid and paratyphoid fever - prevention in travellers. (21301658)
2010
8
Yields from blood cultures of patients with suspected paratyphoid fever A. (24031492)
2010
9
Study on blood cultures and bacteria counts in the blood of paratyphoid fever A patients. (19526258)
2009
10
Epidemiology of typhoid and paratyphoid fever hospitalizations in Spain (1997-2005). (19276655)
2009
11
Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever). (18843701)
2008
12
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (18843659)
2008
13
Laboratory-based surveillance of paratyphoid fever in the United States: travel and antimicrobial resistance. (18422453)
2008
14
Comparisons of predictors for typhoid and paratyphoid fever in Kolkata, India. (17935611)
2007
15
Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever. (17477815)
2007
16
Typhoid and paratyphoid fever. (16125594)
2005
17
Paratyphoid fever in Vellore, South India. (16105360)
2005
18
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (15846718)
2005
19
Typhoid and paratyphoid fever: a 10-year retrospective study of 41 cases in a Parisian hospital. (11726293)
2001
20
Paratyphoid fever in India: An emerging problem. (10341194)
1999
21
Paratyphoid fever due to Salmonella enterica serotype Paratyphi A. (9284393)
1997
22
A relapse of paratyphoid fever after treatment with ciprofloxacin in a child with congenital biliary atresia. (9183498)
1997
23
Monoclonal antibodies against protein antigens of salmonellae causing paratyphoid fever and their diagnostic application. (7488347)
1995
24
Cutaneous leukocytoclastic vasculitis in the rose spot of paratyphoid fever. (6807856)
1982
25
Typhoid and paratyphoid fever. (115625)
1979
26
Influence of chloramphenicol and ampicillin on antibody response in typhoid-paratyphoid fever. (4984110)
1970
27
A comparative trial of furazolidone and chloramphenicol in typhoid and paratyphoid fever. (4995053)
1970
28
COMPARISON OF AMPICILLIN AND CHLORAMPHENICOL IN TREATMENT OF PARATYPHOID FEVER. (14072634)
1964
29
AMPICILLIN IN THE TREATMENT OF PARATYPHOID FEVER--A COMPARATIVE TRIAL. (14246856)
1964
30
Paratyphoid fever traced to desiccated coconut. (13750036)
1961
31
Acute ileitis with ulceration and perforation due to paratyphoid fever; report of eighty-five cases. (13399825)
1957
32
Typhoid and paratyphoid fever; report of six cases with one death. (13361260)
1956
33
PARATYPHOID fever and cream cakes. (13094092)
1953
34
Dissemination of paratyphoid fever from a bakery. (14824638)
1951
35
Typhoid and paratyphoid fever in immunized subjects. (18147216)
1949
36
Thrombocytopenic purpura complicating typhoid and paratyphoid fever. (18141777)
1949
37
Field investigation of paratyphoid fever with typing of Salm. paratyphi B by means of Vi bacteriophage. (20262099)
1947
38
Pregnancy and typhoid, paratyphoid fever. (20246001)
1947
39
Paratyphoid fever. (20296482)
1946
40
Observations on an epidemic of paratyphoid fever in Dundee, 1941. (20475679)
1944
41
Paratyphoid fever: an epidemiological study. (20475641)
1942
42
Paratyphoid Fever and Aertrycke Enteritis in Aberdeen-a Contrast. (20474903)
1926
43
Discussion on Paratyphoid Fever. (19979288)
1916
44
DISCUSSION ON PARATYPHOID FEVER. (19979278)
1916
45
Discussion on Paratyphoid Fever. (19979286)
1916
46
Discussion on Paratyphoid Fever. (19979289)
1916
47
Discussion on Paratyphoid Fever. (19979283)
1916
48
The AEtiology and Epidemiology of Paratyphoid Fever and "Food-poisoning.". (19975429)
1911
49
Report of an Epidemic of Probable Paratyphoid Fever. (19599427)
1910
50
A Note on Paratyphoid Fever from the Public Health Standpoint. (19599793)
1903

Variations for Paratyphoid Fever

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Expression for genes affiliated with Paratyphoid Fever

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Search GEO for disease gene expression data for Paratyphoid Fever.

Pathways for genes affiliated with Paratyphoid Fever

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Pathways related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL1A, IL1R1
2
Show member pathways
9.5IFNGR1, TNF
39.3IFNGR1, IL1B
49.1IL1A, IL1B
59.0IL1B, TNF
69.0IL1B, TNF
79.0IL1B, TNF
8
Apoptosis (WikiPathways)
Show member pathways
9.0IL1B, TNF
98.9IL1A, IL1R1, TNF
10
Show member pathways
8.9CASP1, IL1A, TNF
11
Show member pathways
8.8CASP1, IFNGR1, IL1B
12
Show member pathways
8.7IL1A, IL1B, IL1R1
13
Show member pathways
8.7IL1A, IL1B, IL1R1
148.7CASP1, IL1A, IL1B
15
Show member pathways
8.7IFNGR1, IL1B, TNF
168.6IL1B, IL1R1, TNF
17
Show member pathways
8.6IL1B, IL1R1, TNF
188.6IL1B, IL1R1, TNF
198.6CASP1, IL1B, TNF
20
Show member pathways
8.6CASP1, IL1B, TNF
218.6CASP1, IL1B, TNF
22
Show member pathways
8.5IL1A, IL1B, TNF
238.5IL1A, IL1B, TNF
248.5IL1A, IL1B, TNF
258.5IL1A, IL1B, TNF
268.5IL1A, IL1B, TNF
278.5IL1A, IL1B, TNF
28
Salmonella infection (KEGG)
Show member pathways
8.3IL1A, IL1B, TNF
29
Show member pathways
8.3CASP1, IL1A, IL1B, IL1R1
30
Show member pathways
8.2IFNGR1, IL1B, IL1R1, TNF
31
Show member pathways
8.1IFNGR1, IL1A, IL1B, TNF
32
Show member pathways
8.1IFNGR1, IL1A, IL1B, TNF
338.1IFNGR1, IL1A, IL1B, TNF
348.1IL1A, IL1B, IL1R1, TNF
35
Show member pathways
8.1IL1A, IL1B, IL1R1, TNF
368.1IL1A, IL1B, IL1R1, TNF
378.1CASP1, IL1A, IL1B, TNF
38
Show member pathways
7.7IFNGR1, IL1A, IL1B, IL1R1, TNF
397.7IFNGR1, IL1A, IL1B, IL1R1, TNF
40
Show member pathways
7.7IFNGR1, IL1A, IL1B, IL1R1, TNF
41
Show member pathways
7.7IFNGR1, IL1A, IL1B, IL1R1, TNF
42
Show member pathways
7.7IFNGR1, IL1A, IL1B, IL1R1, TNF
43
Show member pathways
7.7CASP1, IFNGR1, IL1A, IL1B, TNF
44
Apoptosis (KEGG)
Show member pathways
7.6CASP1, IFNGR1, IL1A, IL1B, TNF
45
Show member pathways
7.6CASP1, IL1A, IL1B, IL1R1, TNF
46
Show member pathways
7.6CASP1, IL1A, IL1B, IL1R1, TNF
47
Show member pathways
7.6CASP1, IL1A, IL1B, IL1R1, TNF
487.6CASP1, IL1A, IL1B, IL1R1, TNF
49
Show member pathways
7.3CASP1, IFNGR1, IL1A, IL1B, IL1R1, TNF
50
Show member pathways
6.7CASP1, IFNGR1, IL1A, IL1B, IL1R1, PARK2

GO Terms for genes affiliated with Paratyphoid Fever

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Biological processes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show all 44)
idNameGO IDScoreTop Affiliating Genes
1ovulationGO:00307289.9IL1B, IL1R1
2interleukin-1 beta productionGO:00326119.9CASP1, IL1B
3regulation of autophagyGO:00105069.9CASP1, PARK2
4inflammatory response to antigenic stimulusGO:00024379.8IL1A, IL1B
5fever generationGO:00016609.8IL1A, IL1B
6regulation of reactive oxygen species metabolic processGO:20003779.8PARK2, TNF
7sequestering of triglycerideGO:00307309.7IL1B, TNF
8positive regulation of calcidiol 1-monooxygenase activityGO:00605599.7IL1B, TNF
9regulation of establishment of endothelial barrierGO:19031409.7IL1B, TNF
10extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.7IL1A, IL1B
11ectopic germ cell programmed cell deathGO:00352349.7IL1A, IL1B
12chronic inflammatory response to antigenic stimulusGO:00024399.7IL1B, TNF
13positive regulation of chemokine biosynthetic processGO:00450809.7IL1B, TNF
14positive regulation of interleukin-2 biosynthetic processGO:00450869.7IL1A, IL1B
15positive regulation of membrane protein ectodomain proteolysisGO:00510449.7IL1B, TNF
16negative regulation of lipid catabolic processGO:00509959.7IL1B, TNF
17positive regulation of JUN kinase activityGO:00435079.6IL1B, TNF
18positive regulation of interferon-gamma productionGO:00327299.6IL1B, TNF
19positive regulation of heterotypic cell-cell adhesionGO:00341169.6IL1B, TNF
20positive regulation of NF-kappaB import into nucleusGO:00423469.6IL1B, TNF
21positive regulation of fever generationGO:00316229.6IL1B, TNF
22cellular response to glucose stimulusGO:00713339.6IL1B, IL1R1
23lipopolysaccharide-mediated signaling pathwayGO:00316639.6IL1B, TNF
24protein kinase B signalingGO:00434919.6IL1B, TNF
25positive regulation of vascular endothelial growth factor productionGO:00105759.6IL1A, IL1B
26cellular response to organic substanceGO:00713109.6CASP1, IL1B
27positive regulation of interleukin-8 productionGO:00327579.6IL1B, TNF
28regulation of I-kappaB kinase/NF-kappaB signalingGO:00431229.5IL1B, TNF
29positive regulation of cytokine secretionGO:00507159.5CASP1, IL1A, TNF
30positive regulation of interleukin-6 productionGO:00327559.4IL1B, TNF
31positive regulation of phagocytosisGO:00507669.4IL1B, TNF
32positive regulation of nitric oxide biosynthetic processGO:00454299.3IL1B, TNF
33response to ATPGO:00331989.1CASP1, IL1B
34negative regulation of gene expressionGO:00106298.9IL1B, PARK2, TNF
35inflammatory responseGO:00069548.9IL1A, IL1B, TNF
36positive regulation of mitotic nuclear divisionGO:00458408.8IL1A, IL1B
37positive regulation of JNK cascadeGO:00463308.7IL1A, IL1B, TNF
38positive regulation of ERK1 and ERK2 cascadeGO:00703748.7IL1A, IL1B, TNF
39negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012408.5IL1A, IL1B, TNF
40cytokine-mediated signaling pathwayGO:00192218.5IFNGR1, IL1A, IL1B, IL1R1
41immune responseGO:00069558.4IL1A, IL1B, IL1R1, TNF
42positive regulation of gene expressionGO:00106288.1IL1A, IL1B, PARK2, TNF
43positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431238.0CASP1, IL1A, IL1B, PARK2, TNF
44positive regulation of transcription from RNA polymerase II promoterGO:00459448.0IL1A, IL1B, PARK2, TNF

Molecular functions related to Paratyphoid Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051499.5IL1A, IL1B
2cytokine activityGO:00051258.5IL1A, IL1B, TNF

Sources for Paratyphoid Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet