MCID: PRT002
MIFTS: 54

Paratyphoid Fever malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Paratyphoid Fever

Aliases & Descriptions for Paratyphoid Fever:

Name: Paratyphoid Fever 12 56 42 14 69
Paratyphoid B Fever 12 69
Paratyphoid C Fever 12 69
Paratyphoid a Fever 12
Paratyphoid Fever a 12
Paratyphoid Fever B 12
Paratyphoid Fever C 12
Paratyphoid a 12
Paratyphoid B 12
Paratyphoid C 12
Paratyphoid 12

Characteristics:

Orphanet epidemiological data:

56
paratyphoid fever
Inheritance: Not applicable;

Classifications:

Orphanet: 56  
Rare infectious diseases


Summaries for Paratyphoid Fever

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection located in intestine, has material basis in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has symptom fever, has symptom headache, has symptom abdominal pain, has symptom malaise, has symptom anorexia, has symptom constipation, has symptom rosy spots on the central body, has symptom non productive cough (in early stage of illness), has symptom bradycardia, and has symptom hepatosplenomegaly.

MalaCards based summary : Paratyphoid Fever, also known as paratyphoid b fever, is related to typhoid fever and salmonellosis, and has symptoms including fever, headache and abdominal pain. An important gene associated with Paratyphoid Fever is IFNGR1 (Interferon Gamma Receptor 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Vaccines and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 71 Paratyphoid fever, also known simply as paratyphoid, is a bacterial infection caused by one of the three... more...

Related Diseases for Paratyphoid Fever

Diseases related to Paratyphoid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
id Related Disease Score Top Affiliating Genes
1 typhoid fever 11.5
2 salmonellosis 10.9
3 intravascular papillary endothelial hyperplasia 10.2 IFNG IFNGR1
4 crustacean allergy 10.2 IFNG IFNGR1
5 variola minor 10.1 IFNG IFNGR1
6 chromosome 16p11.2 duplication syndrome autism, susceptibility to, 14b, included 10.1 CASP1 IL1B
7 egg allergy 10.1 IL1B IL1R1
8 chondrodysplasia punctata, rhizomelic, type 1 10.1 IFNGR1 IL1B
9 warthin tumor 10.1 IL1B IL1R1
10 juvenile amyotrophic lateral sclerosis with dementia 10.1 CASP1 TNFRSF1A
11 primary ciliary dyskinesia 10.1 IL1R1 TNFRSF1A
12 amelanotic melanoma 10.1 CASP1 IL1B
13 anal atresia, hypospadias, and penoscrotal inversion 10.1 IFNG IFNGR1
14 microcephaly 10.1 IFNG IFNGR1
15 stocco dos santos syndrome 10.1 IFNG IL1B
16 benign neonatal seizures 10.1 IL1B IL1R1
17 ethmoid sinus cancer 10.1 IFNG IL1B
18 cerebrum cancer 10.0 IL1B TNFRSF1A
19 amyotrophic lateral sclerosis type 14 10.0 IFNG IL1B
20 parkinson disease 11 10.0 IFNG IL1B
21 rosacea 10.0 IFNG IL1B
22 ectodermal dysplasia bartalos type 10.0 IFNG IL1B
23 rickettsialpox 10.0 IFNG IL1B
24 keratoconus 10.0 IL1B IL1R1
25 periventricular leukomalacia 10.0 IFNG IL1B
26 oral cavity carcinoma in situ 10.0 IFNG IL1B
27 familial hyperthyroidism due to mutations in tsh receptor 10.0 CASP1 IL1B IL1R1
28 benign eccrine breast spiradenoma 9.9 IFNG IFNGR1 IL1B
29 senile reticular retinal degeneration 9.9 IFNG IL1B IL1R1
30 dysentery 9.9
31 respiratory system disease 9.9 IFNG IL1B IL1R1
32 bare lymphocyte syndrome, type i 9.9 IFNG IL1B IL1R1
33 patau syndrome 9.9 IL1B TNFRSF1A
34 status epilepticus 9.9 IFNG IL1B
35 gastric leiomyoma 9.9 IL12B IL1B
36 pyloric stenosis, infantile hypertrophic, 2 9.9 CASP1 IL1B TNFRSF1A
37 keratomalacia 9.9 CASP1 IFNG IL1B
38 aortic aneurysm, familial thoracic 6 9.9 IFNG IL1B IL1R1
39 pancreas lymphoma 9.9 IL1B TNFRSF1A
40 complex regional pain syndrome 9.9 IFNG IL1B TNFRSF1A
41 ectothrix infectious disease 9.9 IFNG IL12B
42 goodpasture syndrome 9.9 IFNG IL1B TNFRSF1A
43 advanced sleep phase syndrome, familial, 1 9.9 IFNG IL1B TNFRSF1A
44 nasopharyngitis 9.8 IFNG IL1B
45 biliary atresia 9.8
46 purpura 9.8
47 appendicitis 9.8
48 duodenitis 9.8
49 vasculitis 9.8
50 hepatitis 9.8

Graphical network of the top 20 diseases related to Paratyphoid Fever:



Diseases related to Paratyphoid Fever

Symptoms & Phenotypes for Paratyphoid Fever

Symptoms:

12
  • fever
  • headache
  • abdominal pain
  • malaise
  • anorexia
  • constipation
  • rosy spots on the central body
  • non productive cough (in early stage of illness)
  • bradycardia
  • hepatosplenomegaly

MGI Mouse Phenotypes related to Paratyphoid Fever:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10 CASP1 IFNG IFNGR1 IL1B IL1R1 TNFRSF1A
2 hematopoietic system MP:0005397 10 IL12B IL1B IL1R1 TNFRSF1A CASP1 IFNG
3 homeostasis/metabolism MP:0005376 9.98 IFNG IFNGR1 IL12B IL1B IL1R1 TNFRSF1A
4 immune system MP:0005387 9.95 CASP1 IFNG IFNGR1 IL12B IL1B IL1R1
5 digestive/alimentary MP:0005381 9.89 CASP1 IFNG IFNGR1 IL12B TNFRSF1A
6 endocrine/exocrine gland MP:0005379 9.88 CASP1 IFNG IFNGR1 IL1R1 TNFRSF1A
7 mortality/aging MP:0010768 9.87 CASP1 IFNG IFNGR1 IL12B IL1B IL1R1
8 integument MP:0010771 9.85 CASP1 IFNG IFNGR1 IL1B IL1R1 TNFRSF1A
9 craniofacial MP:0005382 9.81 IFNG IL12B IL1R1 TNFRSF1A
10 neoplasm MP:0002006 9.8 CASP1 IFNG IFNGR1 IL12B IL1B IL1R1
11 nervous system MP:0003631 9.63 IL1R1 TNFRSF1A CASP1 IFNG IFNGR1 IL1B
12 renal/urinary system MP:0005367 9.35 CASP1 IFNG IFNGR1 IL1R1 TNFRSF1A
13 skeleton MP:0005390 9.1 IFNG IFNGR1 IL12B IL1B IL1R1 TNFRSF1A

Drugs & Therapeutics for Paratyphoid Fever

Drugs for Paratyphoid Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 1,Phase 2
2 Pharmaceutical Solutions Phase 1, Phase 2
3 Liver Extracts Phase 1, Phase 2
4 Lecithin Nutraceutical Phase 1, Phase 2
5 Soy Bean Nutraceutical Phase 1, Phase 2

Interventional clinical trials:

(show all 12)
id Name Status NCT ID Phase
1 Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central Vietnam Completed NCT00131820 Phase 4
2 Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China Completed NCT00131833 Phase 4
3 Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in Childhood Completed NCT00125047 Phase 4
4 Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever Completed NCT00125008 Phase 4
5 TY800 Dose Escalation (Typhoid) Completed NCT00269295 Phase 1, Phase 2
6 Safety and Efficacy Study of Mix Vaccine in Prostate Carcinoma Patient Completed NCT02338700 Phase 1, Phase 2
7 Safety and Efficacy Study of Mix Vaccine in Breast Carcinoma Patient Completed NCT02338804 Phase 1, Phase 2
8 Safety and Efficacy Study of Mix Vaccine in Hepatocyte Carcinoma Patient Completed NCT02338778 Phase 1, Phase 2
9 Safety and Efficacy Study of Mix Vaccine in Pancreatic Carcinoma Patient Completed NCT02338752 Phase 1, Phase 2
10 Investigating Enteric Fever - Salmonella Typhi and Paratyphi Challenge Study Recruiting NCT02192008
11 Investigating Typhoid Fever Pathogenesis Recruiting NCT03067961
12 Understanding Paratyphoid Infection Active, not recruiting NCT02100397

Search NIH Clinical Center for Paratyphoid Fever

Cochrane evidence based reviews: paratyphoid fever

Genetic Tests for Paratyphoid Fever

Anatomical Context for Paratyphoid Fever

MalaCards organs/tissues related to Paratyphoid Fever:

39
Skin, Testes, Bone, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Paratyphoid Fever:

18
Intestine

Publications for Paratyphoid Fever

Articles related to Paratyphoid Fever:

(show top 50) (show all 132)
id Title Authors Year
1
Status of paratyphoid fever vaccine research and development. ( 27083427 )
2016
2
Six Cases of Paratyphoid Fever Due to Salmonella Paratyphi A in Travelers Returning from Myanmar Between July 2014 and August 2015. ( 27352874 )
2016
3
Increase in paratyphoid fever cases in Japanese travellers returning from Cambodia in 2013. ( 26169980 )
2015
4
A Large-Scale Community-Based Outbreak of Paratyphoid Fever Caused by Hospital-Derived Transmission in Southern China. ( 26186586 )
2015
5
Recurrent paratyphoid fever A co-infected with hepatitis A reactivated chronic hepatitis B. ( 24884719 )
2014
6
Paratyphoid fever: splicing the global analyses. ( 24904229 )
2014
7
Typhoid and paratyphoid fever. ( 24707582 )
2014
8
Psychosis in paratyphoid fever - a case report from Australia. ( 24820292 )
2014
9
The application of the grey disaster model to forecast epidemic peaks of typhoid and paratyphoid fever in China. ( 23565260 )
2013
10
Correction: The Application of the Grey Disaster Model to Forecast Epidemic Peaks of Typhoid and Paratyphoid Fever in China. ( 24039655 )
2013
11
Spatiotemporal transmission and determinants of typhoid and paratyphoid fever in Hongta District, Yunnan Province, China. ( 23516653 )
2013
12
Typhoid fever and paratyphoid fever: Systematic review to estimate global morbidity and mortality for 2010. ( 23198130 )
2012
13
Study of clinical profile and antibiotic sensitivity in paratyphoid Fever cases admitted at teaching hospital in South India. ( 24479019 )
2012
14
Association between the incidence of typhoid and paratyphoid fever and meteorological variables in Guizhou, China. ( 22490402 )
2012
15
Typhoid and paratyphoid fever in Western Sydney Local Health District, NSW, January-June 2011. ( 23043747 )
2012
16
WITHDRAWN: Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever). ( 21975751 )
2011
17
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). ( 21975746 )
2011
18
Typhoid and paratyphoid fever - prevention in travellers. ( 21301658 )
2010
19
Global trends in typhoid and paratyphoid Fever. ( 20014951 )
2010
20
Burden of typhoid and paratyphoid fever in a densely populated urban community, Dhaka, Bangladesh. ( 20236850 )
2010
21
Yields from blood cultures of patients with suspected paratyphoid fever A. ( 24031492 )
2010
22
Epidemiology of typhoid and paratyphoid fever hospitalizations in Spain (1997-2005). ( 19276655 )
2009
23
Study on blood cultures and bacteria counts in the blood of paratyphoid fever A patients. ( 19526258 )
2009
24
Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever). ( 18843701 )
2008
25
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). ( 18843659 )
2008
26
Epidemiology of typhoid and paratyphoid fever in India. ( 19745523 )
2008
27
Laboratory-based surveillance of paratyphoid fever in the United States: travel and antimicrobial resistance. ( 18422453 )
2008
28
Comparisons of predictors for typhoid and paratyphoid fever in Kolkata, India. ( 17935611 )
2007
29
Ty21a live oral typhoid vaccine and prevention of paratyphoid fever caused by Salmonella enterica Serovar Paratyphi B. ( 17582564 )
2007
30
Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever. ( 17477815 )
2007
31
Deep-seated resistance in relapsed paratyphoid fever. ( 16652303 )
2006
32
PARK2/PACRG polymorphisms and susceptibility to typhoid and paratyphoid fever. ( 16734611 )
2006
33
Typhoid and paratyphoid fever. ( 16125594 )
2005
34
Identification of typhoid fever and paratyphoid fever cases at presentation in outpatient clinics in Jakarta, Indonesia. ( 15837356 )
2005
35
Paratyphoid fever in Vellore, South India. ( 16105360 )
2005
36
Typhoid and paratyphoid fever. ( 16271635 )
2005
37
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). ( 15846718 )
2005
38
Epidemiology of typhoid and paratyphoid fever in Kathmandu: two years study and trends of antimicrobial resistance. ( 16082406 )
2005
39
Typhoid and paratyphoid fever. ( 16271636 )
2005
40
Typhoid and paratyphoid fever in travellers. ( 16183516 )
2005
41
Risk factors for typhoid and paratyphoid fever in Jakarta, Indonesia. ( 15173152 )
2004
42
LipschA1tz genital ulceration: a rare manifestation of paratyphoid fever. ( 12804994 )
2003
43
An unusual paratyphoid fever. ( 11762624 )
2001
44
Typhoid and paratyphoid fever: a 10-year retrospective study of 41 cases in a Parisian hospital. ( 11726293 )
2001
45
Typhoid and paratyphoid fever in south-eastern Sydney, 1992-1997. ( 11022389 )
2000
46
Oral administration of fluoroquinolones in the treatment of typhoid fever and paratyphoid fever in Japan. ( 11197787 )
2000
47
Epidemiological studies of an outbreak of paratyphoid fever in the Shima area of Mie Prefecture. ( 10738368 )
1999
48
Paratyphoid fever in India: An emerging problem. ( 10341194 )
1999
49
A relapse of paratyphoid fever after treatment with ciprofloxacin in a child with congenital biliary atresia. ( 9183498 )
1997
50
Paratyphoid fever due to Salmonella enterica serotype Paratyphi A. ( 9284393 )
1997

Variations for Paratyphoid Fever

Expression for Paratyphoid Fever

Search GEO for disease gene expression data for Paratyphoid Fever.

Pathways for Paratyphoid Fever

Pathways related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 CASP1 IFNG IFNGR1 IL12B IL1B IL1R1
2
Show member pathways
13.43 CASP1 IFNG IFNGR1 IL12B IL1B IL1R1
3
Show member pathways
13.37 IFNG IFNGR1 IL12B IL1B IL1R1 TNFRSF1A
4
Show member pathways
13.16 CASP1 IL12B IL1B IL1R1 TNFRSF1A
5
Show member pathways
13.06 IFNG IFNGR1 IL1B IL1R1 TNFRSF1A
6
Show member pathways
13.06 CASP1 IFNG IFNGR1 IL12B IL1B IL1R1
7
Show member pathways
12.8 IFNG IFNGR1 IL12B IL1B TNFRSF1A
8
Show member pathways
12.63 CASP1 IFNG IL12B IL1B
9 12.61 CASP1 IL1B IL1R1 TNFRSF1A
10
Show member pathways
12.53 IFNG IFNGR1 IL12B TNFRSF1A
11
Show member pathways
12.52 IFNG IFNGR1 IL1B IL1R1 TNFRSF1A
12
Show member pathways
12.5 CASP1 IL12B IL1B IL1R1 TNFRSF1A
13
Show member pathways
12.43 IFNG IL12B IL1B
14
Show member pathways
12.43 IFNG IFNGR1 IL12B IL1B IL1R1
15
Show member pathways
12.43 CASP1 IFNG IFNGR1 IL12B IL1B TNFRSF1A
16 12.39 IFNG IL1B TNFRSF1A
17
Show member pathways
12.2 IFNG IFNGR1 IL1B IL1R1
18
Show member pathways
12.19 CASP1 IL1B IL1R1
19
Show member pathways
12.11 IFNG IFNGR1 IL12B
20
Show member pathways
12.11 IFNG IFNGR1 IL1B IL1R1
21 12.09 IFNG IFNGR1 TNFRSF1A
22
Show member pathways
12.08 IFNG IL12B IL1B
23
Show member pathways
12.04 IFNG IFNGR1 IL12B IL1B TNFRSF1A
24 12.01 IFNG IL1B IL1R1 TNFRSF1A
25 11.94 IFNG IL1B IL1R1
26
Show member pathways
11.89 IFNG IL12B IL1B IL1R1
27
Show member pathways
11.84 IFNG IFNGR1 IL12B IL1B
28 11.82 IL1B IL1R1 TNFRSF1A
29 11.81 IFNG IFNGR1 IL12B IL1B TNFRSF1A
30
Show member pathways
11.79 IFNG IL12B IL1B IL1R1
31 11.74 IFNG IL1B IL1R1
32 11.74 IFNG IL12B IL1B IL1R1
33 11.71 CASP1 IL12B IL1B
34 11.67 CASP1 IFNG IFNGR1 IL1B
35 11.65 IFNG IFNGR1 IL12B
36
Show member pathways
11.62 IFNG IL1B TNFRSF1A
37 11.56 CASP1 IL12B IL1B
38 11.53 IL12B IL1B
39
Show member pathways
11.51 IFNG IFNGR1 TNFRSF1A
40 11.49 IFNG IL12B IL1B
41 11.49 IFNG IL12B IL1B
42 11.46 IL1R1 TNFRSF1A
43 11.43 IFNG TNFRSF1A
44 11.41 IFNG IL1B
45 11.37 IFNG IL1B
46 11.36 IFNG IFNGR1 IL1B
47
Show member pathways
11.35 IL1B IL1R1
48 11.33 CASP1 IL1B
49 11.33 IFNG IL12B IL1B
50
Show member pathways
11.31 IFNG TNFRSF1A

GO Terms for Paratyphoid Fever

Cellular components related to Paratyphoid Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 CASP1 IFNG IL12B IL1B IL1R1 TNFRSF1A

Biological processes related to Paratyphoid Fever according to GeneCards Suite gene sharing:

(show all 37)
id Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.94 CASP1 IFNG IL1B TNFRSF1A
2 immune response GO:0006955 9.87 IFNG IL1B IL1R1 TNFRSF1A
3 response to lipopolysaccharide GO:0032496 9.81 CASP1 IL1B TNFRSF1A
4 defense response to virus GO:0051607 9.77 IFNG IFNGR1 IL12B
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.77 CASP1 IL1B TNFRSF1A
6 positive regulation of inflammatory response GO:0050729 9.67 IL12B TNFRSF1A
7 positive regulation of cell adhesion GO:0045785 9.67 IFNG IL12B
8 positive regulation of tumor necrosis factor production GO:0032760 9.66 IFNG IL12B
9 positive regulation of interferon-gamma production GO:0032729 9.66 IL12B IL1B
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 IFNG IL1B
11 cellular response to organic substance GO:0071310 9.65 CASP1 IL1B
12 negative regulation of smooth muscle cell proliferation GO:0048662 9.65 IFNG IL12B
13 positive regulation of interleukin-12 production GO:0032735 9.64 IFNG IL12B
14 positive regulation of interleukin-1 beta secretion GO:0050718 9.63 CASP1 IFNG
15 positive regulation of NF-kappaB import into nucleus GO:0042346 9.62 IL12B IL1B
16 positive regulation of osteoclast differentiation GO:0045672 9.62 IFNG IL12B
17 defense response to protozoan GO:0042832 9.61 IFNG IL12B
18 response to ATP GO:0033198 9.61 CASP1 IL1B
19 negative regulation of growth of symbiont in host GO:0044130 9.58 IFNG IL12B
20 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 IFNG IL1B
21 cellular response to mechanical stimulus GO:0071260 9.58 CASP1 IL1B TNFRSF1A
22 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.56 IFNG IFNGR1
23 cell surface receptor signaling pathway GO:0007166 9.56 IFNG IL12B IL1R1 TNFRSF1A
24 negative regulation of interleukin-17 production GO:0032700 9.55 IFNG IL12B
25 positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 9.54 IFNG TNFRSF1A
26 positive regulation of T cell proliferation GO:0042102 9.54 IFNG IL12B IL1B
27 positive regulation of chemokine biosynthetic process GO:0045080 9.52 IFNG IL1B
28 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.51 IL12B IL1B
29 positive regulation of smooth muscle cell apoptotic process GO:0034393 9.49 IFNG IL12B
30 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.48 IFNG IL1B
31 regulation of defense response to virus by host GO:0050691 9.46 IFNG IL1B
32 regulation of establishment of endothelial barrier GO:1903140 9.43 IL1B TNFRSF1A
33 interleukin-1 beta production GO:0032611 9.32 CASP1 IL1B
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IFNG IL1B
35 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.13 IFNG IL12B TNFRSF1A
36 cytokine-mediated signaling pathway GO:0019221 8.92 IL12B IL1B IL1R1 TNFRSF1A
37 signal transduction GO:0007165 10.06 CASP1 IFNGR1 IL1B IL1R1 TNFRSF1A

Molecular functions related to Paratyphoid Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IFNG IL12B IL1B

Sources for Paratyphoid Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
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48 NDF-RT
51 NINDS
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54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
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68 Tocris
69 UMLS
70 UMLS via Orphanet
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