MCID: PRS063
MIFTS: 35

Paresthesia malady

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Summaries for Paresthesia

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44NINDS, 65Wikipedia, 33MalaCards
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NINDS:44 Paresthesia refers to a burning or prickling sensation that is usually felt in the hands, arms, legs, or feet, but can also occur in other parts of the body. The sensation, which happens without warning, is usually painless and described as tingling or numbness, skin crawling, or itching.Most people have experienced temporary paresthesia -- a feeling of "pins and needles" -- at some time in their lives when they have sat with legs crossed for too long, or fallen asleep with an arm crooked under their head. It happens when sustained pressure is placed on a nerve. The feeling quickly goes away once the pressure is relieved.Chronic paresthesia is often a symptom of an underlying neurological disease or traumatic nerve damage. Paresthesia can be caused by disorders affecting the central nervous system, such as stroke and transient ischemic attacks (mini-strokes), multiple sclerosis, transverse myelitis, and encephalitis. A tumor or vascular lesion pressed up against the brain or spinal cord can also cause paresthesia. Nerve entrapment syndromes, such as carpal tunnel syndrome, can damage peripheral nerves and cause paresthesia accompanied by pain. Diagnostic evaluation is based on determining the underlying condition causing the paresthetic sensations. An individual's medical history, physical examination, and laboratory tests are essential for the diagnosis. Physicians may order additional tests depending on the suspected cause of the paresthesia.

MalaCards: Paresthesia is related to cervicitis and burns. An important gene associated with Paresthesia is SLC12A3 (solute carrier family 12 (sodium/chloride transporter), member 3), and among its related pathways is RNA Polymerase I Promoter Opening. The compounds melphalan and neopterin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and testes, and related mouse phenotype homeostasis/metabolism.

Wikipedia:65 Paresthesia (/?p more...

Aliases & Classifications for Paresthesia

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44NINDS
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Aliases & Descriptions:

paresthesia 44


Related Diseases for Paresthesia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Paresthesia:



Diseases related to paresthesia

Symptoms for Paresthesia

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Drugs & Therapeutics for Paresthesia

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Paresthesia

Genetic Tests for Paresthesia

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Anatomical Context for Paresthesia

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33MalaCards
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MalaCards organs/tissues related to Paresthesia:

33
Spinal cord, Skin, Testes, Brain, Bone, Cortex, Liver, Salivary gland, Tongue

Animal Models for Paresthesia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Paresthesia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.5SLC12A3, TTR, TNF

Publications for Paresthesia

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52PubMed
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Articles related to Paresthesia:

(show top 50)    (show all 240)
idTitleAuthorsYear
1
Effect of infrared laser in the prevention and treatment of paresthesia in orthognathic surgery. (23714864)
2013
2
Guillain-BarrAc syndrome variant with prominent facial diplegia, limb paresthesia, and brisk reflexes. (21769530)
2012
3
Effect of slow-release I^-alanine tablets on absorption kinetics and paresthesia. (22139410)
2012
4
Paresthesia during orthodontic treatment: case report and review. (21909501)
2011
5
Occurrence of paresthesia after dental local anesthetic administration in the United States. (20592403)
2010
6
A novel surgical approach to impacted mandibular third molars to reduce the risk of paresthesia: a case series. (20156664)
2010
7
More about oral paresthesia. (21037187)
2010
8
"Abscess" as a perioperative risk factor for paresthesia after third molar extraction under general anesthesia. (19138638)
2009
9
Idiopathic sclerosing orbital inflammation: two cases presenting with paresthesia. (19273935)
2009
10
Efficacy of gabapentin versus diclofenac in the treatment of chest pain and paresthesia in patients with sternotomy. (19819790)
2009
11
Left somatosensory cortex tumor presented with radicular hand pain and paresthesia. (18154431)
2008
12
Ultrasound, paresthesia, and motor response. (18035309)
2007
13
Pattern of paresthesia in patients with carpal tunnel syndrome. (17466582)
2007
14
Effects of electrode positioning on perception threshold and paresthesia coverage in spinal cord stimulation. (22151810)
2007
15
Inferior alveolar nerve paresthesia caused by a dentigerous cyst associated with three teeth. (17767104)
2007
16
Labiomandibular paresthesia caused by endodontic treatment: an anatomic and clinical study. (16997095)
2006
17
Mental nerve paresthesia associated with endodontic paste within the mandibular canal: report of a case. (17052625)
2006
18
Unexpected return of sensation following 4.5 years of paresthesia: case report. (16361887)
2005
19
Simultaneous paresthesia of the lingual nerve and inferior alveolar nerve caused by a radicular cyst. (16186760)
2005
20
Mandibular endodontic-related paresthesia. (15366300)
2004
21
Muscle weakness and paresthesia associated with epidural analgesia in a patient with an intrathecal neurofibrolipoma as part of a tethered cord syndrome. (15281540)
2004
22
Mental nerve paresthesia associated with an adhesive resin restoration: a case report. (14977311)
2004
23
Incidence of chest wall paresthesia after video-assisted thoracic surgery for primary spontaneous pneumothorax. (15145009)
2004
24
What happened to the paresthesia? (12552226)
2003
25
Fascicular anatomy, nervi nervorum, and paresthesia. (12567353)
2003
26
Apicoectomy of an endosseous implant to relieve paresthesia: a case report. (14560478)
2003
27
Idiopathic paresthesia reaction associated with rofecoxib. (11847946)
2002
28
The lumbrical provocation test in subjects with median inclusive paresthesia. (11441381)
2001
29
Alkylamides that produce tingling paresthesia activate tactile and thermal trigeminal neurons. (10526142)
1999
30
Does the interscalene block require paresthesia? (9223211)
1997
31
Temporary paresthesia of the lower lip: a complication of orthodontic treatment. A case report. (9088598)
1997
32
Infection-related mental and inferior alveolar nerve paresthesia: literature review and presentation of two cases. (9587302)
1997
33
Cutaneous paresthesia. (9216516)
1997
34
The pants paresthesia syndrome: a ten-year follow-up. (8886533)
1996
35
Mental nerve paresthesia associated with a non-vital tooth. (9206379)
1996
36
Contactants that produce pruritus and paresthesia with invisible reactions (nonrash) (7614837)
1995
37
Paresthesia in envenomation by the scorpion Leiurus quinquestriatus. (7837317)
1995
38
Thallium poisoning presenting with abdominal colic, paresthesia, and irritability. (7760453)
1995
39
Paresthesia induced by cutaneous infection with herpes simplex virus in rats. (7644115)
1995
40
Paresthesia as a result of local anesthetic. (7741937)
1994
41
Progressive paresthesia of the trigeminal nerve. (8419576)
1993
42
Interscalene brachial plexus block for shoulder surgery: a proximal paresthesia is effective. (1510259)
1992
43
Diarrhea, fever, paresthesia and shortness of breath. (2123781)
1990
44
Pruritus and paresthesia after i.v. administration of Gd-DTPA. (2505565)
1989
45
Subclavian perivascular block: influence of location of paresthesia. (2735542)
1989
46
Paresthesia of the inferior alveolar nerve caused by periodontal-endodontic pathosis. (3468471)
1987
47
Lip paresthesia. A case report. (3858756)
1985
48
Contact "pants paresthesia syndrome". (6839756)
1983
49
Postextraction osseous repair as a cause of paresthesia. (6953188)
1982
50
Iontophoresis and ultrasound for postsurgical temporomandibular trismus and paresthesia. (7355161)
1980

Variations for Paresthesia

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Expression for genes affiliated with Paresthesia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paresthesia

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Pathways for genes affiliated with Paresthesia

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50PathCards, 55Reactome, 30KEGG
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Compounds for genes affiliated with Paresthesia

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 3BitterDB, 24HMDB
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Compounds related to Paresthesia according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1melphalan45 51 1111.4TTR, TNF
2neopterin459.4TTR, TNF
3fibrinogen459.3TTR, TNF
4genistein45 29 61 3 24 1114.3TNF, TTR
5chlorine45 2410.3SLC12A3, TTR
6cyclosporin a45 29 6111.2TTR, TNF
7guanine45 24 1111.2SLC12A3, TTR
8lactate459.2TTR, TNF
9leucine459.0TTR, SLC12A3
10alanine459.0SLC12A3, TTR
11dexamethasone45 51 29 1112.0TTR, TNF
12threonine458.7SLC12A3, TTR
13serine458.7TNF, TTR, SLC12A3

GO Terms for genes affiliated with Paresthesia

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16Gene Ontology
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Biological processes related to Paresthesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:0301989.1TTR, TNF
2transportGO:0068108.7SLC12A3, TTR

Molecular functions related to Paresthesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1TTR, TNF

Products for genes affiliated with Paresthesia

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  • Antibodies
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Sources for Paresthesia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet