Summaries for Paresthesia

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NINDS:42 Paresthesia refers to a burning or prickling sensation that is usually felt in the hands, arms, legs, or feet, but can also occur in other parts of the body. The sensation, which happens without warning, is usually painless and described as tingling or numbness, skin crawling, or itching.Most people have experienced temporary paresthesia -- a feeling of "pins and needles" -- at some time in their lives when they have sat with legs crossed for too long, or fallen asleep with an arm crooked under their head. It happens when sustained pressure is placed on a nerve. The feeling quickly goes away once the pressure is relieved.Chronic paresthesia is often a symptom of an underlying neurological disease or traumatic nerve damage. Paresthesia can be caused by disorders affecting the central nervous system, such as stroke and transient ischemic attacks (mini-strokes), multiple sclerosis, transverse myelitis, and encephalitis. A tumor or vascular lesion pressed up against the brain or spinal cord can also cause paresthesia. Nerve entrapment syndromes, such as carpal tunnel syndrome, can damage peripheral nerves and cause paresthesia accompanied by pain. Diagnostic evaluation is based on determining the underlying condition causing the paresthetic sensations. An individual's medical history, physical examination, and laboratory tests are essential for the diagnosis. Physicians may order additional tests depending on the suspected cause of the paresthesia.

MalaCards based summary: Paresthesia is related to liver disease and hypocalcemia, autosomal dominant. An important gene associated with Paresthesia is SLC12A3 (solute carrier family 12 (sodium/chloride transporter), member 3), and among its related pathways is RNA Polymerase I Promoter Opening. The compounds melphalan and neopterin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, testes and skin, and related mouse phenotype homeostasis/metabolism.

Wikipedia:63 Paresthesia (/?p more...

Aliases & Classifications for Paresthesia

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Paresthesia, Aliases & Descriptions:

Name: Paresthesia 42


Related Diseases for Paresthesia

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Diseases related to Paresthesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1liver disease29.7TNF, TTR
2hypocalcemia, autosomal dominant10.2
3burns10.2
4cervicitis10.2
5porphyria, acute intermittent10.1
6fabry disease10.1
7cerebritis10.1
8dermatitis10.1
9back pain10.1
10chediak-higashi syndrome10.0
11ehlers-danlos syndrome, type iii10.0
12breast cancer10.0
13wegener granulomatosis10.0
14haim-munk syndrome10.0
15gitelman syndrome10.0
16schindler disease, type i10.0
17migraine10.0
18cerebral amyloid angiopathy10.0
19mucopolysaccharidosis is10.0
20stuve-wiedemann syndrome/schwartz-jampel type 2 syndrome10.0
21multiple endocrine neoplasia iia10.0
22thalassemia, hispanic gamma-delta-beta10.0
23neuropathy, recurrent, with pressure palsies10.0
24myotonia congenita, atypical, acetazolamide-responsive10.0
25behcet's disease10.0
26thromboangiitis obliterans10.0
27hemorrhagic thrombocythemia10.0
28fragile x-associated tremor/ataxia syndrome10.0
29acromegaly10.0
30neuronitis10.0
31polyarteritis nodosa10.0
32cronkhite-canada syndrome10.0
33lyme disease10.0
34amyotrophic neuralgia10.0
35herpes zoster10.0
36thoracic outlet syndrome10.0
37tabes dorsalis10.0
38rabies10.0
39arachnoiditis10.0
40alveolar echinococcosis10.0
41melas syndrome10.0
42cogan syndrome10.0
43adiposis dolorosa10.0
44temporal arteritis10.0
45allergic contact dermatitis10.0
46contact dermatitis10.0
47herpes simplex10.0
48periodontitis10.0
49degos disease10.0
50eosinophilic fasciitis10.0

Graphical network of the top 20 diseases related to Paresthesia:



Diseases related to paresthesia

Symptoms for Paresthesia

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Drugs & Therapeutics for Paresthesia

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Drug clinical trials:

Search ClinicalTrials for Paresthesia

Search NIH Clinical Center for Paresthesia

Genetic Tests for Paresthesia

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Anatomical Context for Paresthesia

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MalaCards organs/tissues related to Paresthesia:

31
Spinal cord, Testes, Skin, Brain, Bone, Breast, Cortex, Liver, Salivary gland, Dorsal root ganglion, Tongue

Animal Models for Paresthesia or affiliated genes

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MGI Mouse Phenotypes related to Paresthesia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.5SLC12A3, TTR, TNF

Publications for Paresthesia

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Articles related to Paresthesia:

(show top 50)    (show all 262)
idTitleAuthorsYear
1
Diagnostic role of magnetic resonance imaging in assessing orofacial pain and paresthesia. (25148636)
2014
2
How fast pain, numbness, and paresthesia resolves after lumbar nerve root decompression: a retrospective study of patient's self-reported computerized pain drawing. (24480941)
2014
3
Cleaning and decompression of inferior alveolar canal to treat dysesthesia and paresthesia following endodontic treatment of a third molar. (25099006)
2014
4
Comprehensive visualization of paresthesia in breast cancer survivors. (24496514)
2014
5
Multiple Locations of Nerve Compression: An Unusual Cause of Persistent Lower Limb Paresthesia. (25128915)
2014
6
Guillain-BarrAc syndrome variant with prominent facial diplegia, limb paresthesia, and brisk reflexes. (21769530)
2012
7
Paresthesia during orthodontic treatment: case report and review. (21909501)
2011
8
Occurrence of paresthesia after dental local anesthetic administration in the United States. (20592403)
2010
9
A novel surgical approach to impacted mandibular third molars to reduce the risk of paresthesia: a case series. (20156664)
2010
10
Endodontics-related paresthesia of the mental and inferior alveolar nerves: an updated review. (21118633)
2010
11
More about oral paresthesia. (21037187)
2010
12
"Abscess" as a perioperative risk factor for paresthesia after third molar extraction under general anesthesia. (19138638)
2009
13
Idiopathic sclerosing orbital inflammation: two cases presenting with paresthesia. (19273935)
2009
14
Efficacy of gabapentin versus diclofenac in the treatment of chest pain and paresthesia in patients with sternotomy. (19819790)
2009
15
Left somatosensory cortex tumor presented with radicular hand pain and paresthesia. (18154431)
2008
16
Ultrasound, paresthesia, and motor response. (18035309)
2007
17
Pattern of paresthesia in patients with carpal tunnel syndrome. (17466582)
2007
18
Effects of electrode positioning on perception threshold and paresthesia coverage in spinal cord stimulation. (22151810)
2007
19
Inferior alveolar nerve paresthesia caused by a dentigerous cyst associated with three teeth. (17767104)
2007
20
Labiomandibular paresthesia caused by endodontic treatment: an anatomic and clinical study. (16997095)
2006
21
Mental nerve paresthesia associated with endodontic paste within the mandibular canal: report of a case. (17052625)
2006
22
Unexpected return of sensation following 4.5 years of paresthesia: case report. (16361887)
2005
23
Simultaneous paresthesia of the lingual nerve and inferior alveolar nerve caused by a radicular cyst. (16186760)
2005
24
Mandibular endodontic-related paresthesia. (15366300)
2004
25
Muscle weakness and paresthesia associated with epidural analgesia in a patient with an intrathecal neurofibrolipoma as part of a tethered cord syndrome. (15281540)
2004
26
Mental nerve paresthesia associated with an adhesive resin restoration: a case report. (14977311)
2004
27
Incidence of chest wall paresthesia after video-assisted thoracic surgery for primary spontaneous pneumothorax. (15145009)
2004
28
What happened to the paresthesia? (12552226)
2003
29
Fascicular anatomy, nervi nervorum, and paresthesia. (12567353)
2003
30
Idiopathic paresthesia reaction associated with rofecoxib. (11847946)
2002
31
The lumbrical provocation test in subjects with median inclusive paresthesia. (11441381)
2001
32
Alkylamides that produce tingling paresthesia activate tactile and thermal trigeminal neurons. (10526142)
1999
33
Does the interscalene block require paresthesia? (9223211)
1997
34
Temporary paresthesia of the lower lip: a complication of orthodontic treatment. A case report. (9088598)
1997
35
Infection-related mental and inferior alveolar nerve paresthesia: literature review and presentation of two cases. (9587302)
1997
36
The pants paresthesia syndrome: a ten-year follow-up. (8886533)
1996
37
Mental nerve paresthesia associated with a non-vital tooth. (9206379)
1996
38
Contactants that produce pruritus and paresthesia with invisible reactions (nonrash) (7614837)
1995
39
Paresthesia in envenomation by the scorpion Leiurus quinquestriatus. (7837317)
1995
40
Thallium poisoning presenting with abdominal colic, paresthesia, and irritability. (7760453)
1995
41
Paresthesia induced by cutaneous infection with herpes simplex virus in rats. (7644115)
1995
42
Paresthesia as a result of local anesthetic. (7741937)
1994
43
Progressive paresthesia of the trigeminal nerve. (8419576)
1993
44
Interscalene brachial plexus block for shoulder surgery: a proximal paresthesia is effective. (1510259)
1992
45
Diarrhea, fever, paresthesia and shortness of breath. (2123781)
1990
46
Pruritus and paresthesia after i.v. administration of Gd-DTPA. (2505565)
1989
47
Lip paresthesia. A case report. (3858756)
1985
48
Contact "pants paresthesia syndrome". (6839756)
1983
49
Postextraction osseous repair as a cause of paresthesia. (6953188)
1982
50
Iontophoresis and ultrasound for postsurgical temporomandibular trismus and paresthesia. (7355161)
1980

Variations for Paresthesia

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Expression for genes affiliated with Paresthesia

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Search GEO for disease gene expression data for Paresthesia.

Pathways for genes affiliated with Paresthesia

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Compounds for genes affiliated with Paresthesia

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Compounds related to Paresthesia according to GeneCards Suite gene sharing:

(show all 13)
idCompoundScoreTop Affiliating Genes
1melphalan43 49 1211.4TTR, TNF
2neopterin439.4TTR, TNF
3fibrinogen439.3TTR, TNF
4genistein43 28 59 2 24 1214.3TNF, TTR
5chlorine43 2410.3SLC12A3, TTR
6cyclosporin a43 28 5911.2TTR, TNF
7guanine43 24 1211.2SLC12A3, TTR
8lactate439.2TTR, TNF
9leucine439.0TTR, SLC12A3
10alanine439.0SLC12A3, TTR
11dexamethasone43 49 28 1212.0TTR, TNF
12threonine438.7SLC12A3, TTR
13serine438.7TNF, TTR, SLC12A3

GO Terms for genes affiliated with Paresthesia

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Biological processes related to Paresthesia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:00301989.1TTR, TNF
2transportGO:00068108.7SLC12A3, TTR

Molecular functions related to Paresthesia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:00428029.1TTR, TNF

Products for genes affiliated with Paresthesia

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  • Antibodies
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Sources for Paresthesia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet