MCID: PRS063
MIFTS: 22

Paresthesia malady

Summaries for Paresthesia

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Paresthesia refers to a burning or prickling sensation that is usually felt in the hands, arms, legs, or feet, but can also occur in other parts of the body. The sensation, which happens without warning, is usually painless and described as tingling or numbness, skin crawling, or itching.Most people have experienced temporary paresthesia -- a feeling of "pins and needles" -- at some time in their lives when they have sat with legs crossed for too long, or fallen asleep with an arm crooked under their head. It happens when sustained pressure is placed on a nerve. The feeling quickly goes away once the pressure is relieved.Chronic paresthesia is often a symptom of an underlying neurological disease or traumatic nerve damage. Paresthesia can be caused by disorders affecting the central nervous system, such as stroke and transient ischemic attacks (mini-strokes), multiple sclerosis, transverse myelitis, and encephalitis. A tumor or vascular lesion pressed up against the brain or spinal cord can also cause paresthesia. Nerve entrapment syndromes, such as carpal tunnel syndrome, can damage peripheral nerves and cause paresthesia accompanied by pain. Diagnostic evaluation is based on determining the underlying condition causing the paresthetic sensations. An individual's medical history, physical examination, and laboratory tests are essential for the diagnosis. Physicians may order additional tests depending on the suspected cause of the paresthesia.

MalaCards: Paresthesia is related to cervicitis and burns. An important gene associated with Paresthesia is SLC12A3 (solute carrier family 12 (sodium/chloride transporter), member 3), and among its related pathways is Hematopoietic cell lineage. The compounds chlorine and melphalan have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and spinal cord.

Wikipedia:63 Paresthesia (/ˌpærɨsˈθiːziə/ or /ˌpærɨsˈθiːʒə/), is a sensation of tingling, tickling,... more...

Aliases & Classifications for Paresthesia

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43NINDS
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Aliases & Descriptions:

paresthesia 43


Related Diseases for Paresthesia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Paresthesia:



Diseases related to paresthesia

Clinical Features for Paresthesia

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Drugs & Therapeutics for Paresthesia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Paresthesia

Genetic Tests for Paresthesia

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Anatomical Context for Paresthesia

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32MalaCards
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MalaCards organs/tissues related to Paresthesia:

32
Skin, Brain, Spinal cord, Testes

Animal Models for Paresthesia or affiliated genes

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Publications for Paresthesia

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Genetic Variations for Paresthesia

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Expression for genes affiliated with Paresthesia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paresthesia

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Pathways for genes affiliated with Paresthesia

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29KEGG
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Pathways related to Paresthesia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.8IL7R, CD24, TNF

Compounds for genes affiliated with Paresthesia

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Sources:
44Novoseek, 24HMDB, 11DrugBank
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Compounds related to Paresthesia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1chlorine44 2410.2SLC12A3, TTR
2melphalan44 1110.0TTR, TNF
3neopterin448.8TTR, TNF

GO Terms for genes affiliated with Paresthesia

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16Gene Ontology
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Cellular components related to Paresthesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451219.3CD24, TNF

Biological processes related to Paresthesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of MAP kinase activityGO:0434069.3CD24, TNF
2cell activationGO:0017759.0CD24, TNF

Products for genes affiliated with Paresthesia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Paresthesia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet