MCID: PRS063
MIFTS: 32

Paresthesia malady

Summaries for Paresthesia

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Paresthesia refers to a burning or prickling sensation that is usually felt in the hands, arms, legs, or feet, but can also occur in other parts of the body. The sensation, which happens without warning, is usually painless and described as tingling or numbness, skin crawling, or itching.Most people have experienced temporary paresthesia -- a feeling of "pins and needles" -- at some time in their lives when they have sat with legs crossed for too long, or fallen asleep with an arm crooked under their head. It happens when sustained pressure is placed on a nerve. The feeling quickly goes away once the pressure is relieved.Chronic paresthesia is often a symptom of an underlying neurological disease or traumatic nerve damage. Paresthesia can be caused by disorders affecting the central nervous system, such as stroke and transient ischemic attacks (mini-strokes), multiple sclerosis, transverse myelitis, and encephalitis. A tumor or vascular lesion pressed up against the brain or spinal cord can also cause paresthesia. Nerve entrapment syndromes, such as carpal tunnel syndrome, can damage peripheral nerves and cause paresthesia accompanied by pain. Diagnostic evaluation is based on determining the underlying condition causing the paresthetic sensations. An individual's medical history, physical examination, and laboratory tests are essential for the diagnosis. Physicians may order additional tests depending on the suspected cause of the paresthesia.

MalaCards: Paresthesia is related to back pain and tabes dorsalis. An important gene associated with Paresthesia is SLC12A3 (solute carrier family 12 (sodium/chloride transporter), member 3), and among its related pathways is Hematopoietic cell lineage. The compounds chlorine and melphalan have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord.

Wikipedia:64 Paresthesia (/ˌpærɨsˈθiːziə/ or /ˌpærɨsˈθiːʒə/), is a sensation of tingling, tickling,... more...

Aliases & Classifications for Paresthesia

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44NINDS
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Aliases & Descriptions:

paresthesia 44


Related Diseases for Paresthesia

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Paresthesia:



Diseases related to paresthesia

Clinical Features for Paresthesia

Drugs & Therapeutics for Paresthesia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Paresthesia

Anatomical Context for Paresthesia

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33MalaCards
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MalaCards organs/tissues related to Paresthesia:

33
Brain, Cortex, Spinal cord, Skeletal muscle, Liver, Salivary gland, Skin, Trigeminal ganglion, Tongue

Animal Models for Paresthesia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Paresthesia

Sources:
51PubMed
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Articles related to Paresthesia:

(show top 50)    (show all 242)
idTitleAuthorsYear
1
Influence of upper extremity positioning on pain, paresthesia, and tolerance: advancing current practice. (23702855)
2013
2
Spinal cord stimulation paresthesia and activity of primary afferents. (22900508)
2012
3
Treatment of traumatic infra orbital nerve paresthesia. (23833503)
2012
4
Paresthesia during orthodontic treatment: case report and review. (21909501)
2011
5
Paresthesia and forearm pain after phlebotomy due to medial antebrachial cutaneous nerve injury. (21896172)
2011
6
More about oral paresthesia. (21037187)
2010
7
Inferior alveolar nerve paresthesia secondary to orthodontic tooth movement: report of a case. (20156669)
2010
8
Inferior alveolar nerve paresthesia after overfilling of endodontic sealer into the mandibular canal. (20647109)
2010
9
"Abscess" as a perioperative risk factor for paresthesia after third molar extraction under general anesthesia. (19138638)
2009
10
Delayed paresthesia of inferior alveolar nerve after extraction of mandibular third molar: case report and possible etiology. (19615596)
2009
11
Left somatosensory cortex tumor presented with radicular hand pain and paresthesia. (18154431)
2008
12
Labiomandibular paresthesia caused by endodontic treatment: an anatomic and clinical study. (16997095)
2006
13
Distal lower extremity paresthesia and foot drop developing during adalimumab therapy. (16227104)
2005
14
August 2004: 64-year-old man with intermittent paresthesia of the abdomen and of the legs. (15779244)
2005
15
Mandibular endodontic-related paresthesia. (15366300)
2004
16
Incidence of chest wall paresthesia after video-assisted thoracic surgery for primary spontaneous pneumothorax. (15145009)
2004
17
Syringomyelia in a college football player with motor weakness and paresthesias. (15237903)
2004
18
Paresthesia but no motor response: what's going on? (12552224)
2003
19
Paresthesia associated with local anesthetics: a perspective on articaine. (15055644)
2003
20
Inferior alveolar nerve paresthesia relieved by microscopic endodontic treatment. (15103918)
2003
21
A review of paresthesia in association with administration of local anesthesia. (12680261)
2003
22
Paresthesia of the mental nerve. (11458238)
2001
23
What is the relationship between paresthesia and nerve stimulation for axillary brachial plexus block? (11251131)
2001
24
Paresthesia of the mental nerve induced by periapical infection: a case report. (11113821)
2000
25
Fingertip paresthesia and occupational allergic contact dermatitis caused by acrylics in a dental nurse. (9506232)
1998
26
Spinal geometry and paresthesia coverage in spinal cord stimulation. (22150980)
1998
27
Tactile, thermal and pain sensibility in burned patients with and without chronic pain and paresthesia problems. (9808349)
1998
28
Lingual nerve paresthesia following third molar surgery: a retrospective clinical study. (9347495)
1997
29
Effect of anode-cathode configuration on paresthesia coverage in spinal cord stimulation. (9310984)
1997
30
Headache, circumoral paresthesia, and facial flushing associated with high-dose carmustine infusion. (9134180)
1997
31
Paresthesia in envenomation by the scorpion Leiurus quinquestriatus. (7837317)
1995
32
Thallium poisoning presenting with abdominal colic, paresthesia, and irritability. (7760453)
1995
33
Area of paresthesia as determinant of sensory block in axillary brachial plexus block. (8608067)
1995
34
A 21 year retrospective study of reports of paresthesia following local anesthetic administration. (7736335)
1995
35
Interscalene brachial plexus block for shoulder surgery: a proximal paresthesia is effective. (1510259)
1992
36
Distal paresthesia in patients with cervical cord lesions. (1330246)
1992
37
Facial and neck paresthesia associated with nafarelin administration. (1830009)
1991
38
Pruritus and paresthesia after i.v. administration of Gd-DTPA. (2505565)
1989
39
Paresthesia of the second division of the trigeminal nerve secondary to endodontic manipulation with N2. (3557957)
1987
40
Lip paresthesia. A case report. (3858756)
1985
41
Paresthesia of the mental nerve after overextension with AH26 and gutta-percha: report of case. (3856599)
1985
42
Post-bronchoscopy palatine paresthesia. (6697811)
1984
43
Paresthesia resulting from local anesthetics. (6585500)
1984
44
Intraosseous lipogranuloma presenting with mental nerve paresthesia. (6582238)
1984
45
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. (6945343)
1981
46
Paresthesia of the inferior alveolar nerve caused by Hydron: a case report. (6935355)
1980
47
Pinched belly paresthesia. (7363667)
1980
48
Calcified plaque in the cervical spine with pain and paresthesia. (762817)
1979
49
Paresthesia following endodontic treatment. (1069090)
1976
50
Quinine for the relief of paresthesia of undetermined origin. (12993271)
1952

Genetic Variations for Paresthesia

Expression for genes affiliated with Paresthesia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paresthesia

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Pathways for genes affiliated with Paresthesia

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30KEGG
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Pathways related to Paresthesia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.8IL7R, CD24, TNF

Compounds for genes affiliated with Paresthesia

Sources:
45Novoseek, 24HMDB, 11DrugBank
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Compounds related to Paresthesia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1chlorine45 2410.2SLC12A3, TTR
2melphalan45 1110.0TTR, TNF
3neopterin458.8TTR, TNF

GO Terms for genes affiliated with Paresthesia

Sources:
16Gene Ontology
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Cellular components related to Paresthesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451219.3CD24, TNF

Biological processes related to Paresthesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of MAP kinase activityGO:0434069.3CD24, TNF
2cell activationGO:0017759.0CD24, TNF

Products for genes affiliated with Paresthesia

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Sources for Paresthesia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet