Parkinson Disease 1 malady

MalaCards: Parkinson Disease 1, also known as parkinson disease, is related to parkinson's disease and dementia. An important gene associated with Parkinson Disease 1 is SH3KBP1 (SH3-domain kinase binding protein 1). The drugs bromocriptine and pergolide have been mentioned in the context of this disorder.

OMIM: 168601

parkinson disease 1 33 parkinson disease 43

Disease types for parkinson's disease family:

parkinson disease type 3	parkinson disease type 9
parkinson disease 10	parkinson disease-16
parkinson disease 12	parkinson disease 11
parkinson disease 5	parkinson disease 4
parkinson disease 1	parkinson disease 14

Diseases related to parkinson disease 1 by text searches and GeneDecks gene sharing:

(show top 50)    (show all 62)

id	Related Disease	Score	Top Affiliating Genes
1	parkinson's disease	38.0	SNCA, SH3KBP1
2	dementia	8.9
3	alzheimer's disease	8.4
4	lrrk2-related parkinson disease	8.2
5	autosomal recessive juvenile parkinson disease	7.9
6	htra2-related parkinson disease	7.7
7	pink1 type of young-onset parkinson disease	7.7
8	parkinson disease type 3	7.7
9	neurodegeneration	7.5
10	neuronitis	7.5
11	parkin type of juvenile parkinson disease	7.5
12	park7-related parkinson disease	7.5
13	snca-related parkinson disease	7.5
14	essential tremor	7.5
15	parkinson disease type 9	7.2
16	parkinson disease 10	7.2
17	tremor	7.2
18	parkinson disease 15, autosomal recessive	6.8
19	parkinson disease 14	6.8
20	parkinson disease 4	6.8
21	parkinson disease, resistance to	6.8
22	postencephalitic parkinson disease	6.8
23	secondary parkinson disease	6.8
24	neuroblastoma	6.8
25	parkinson disease multi-gene panels	6.8
26	parkinson disease 6, early onset	6.8
27	parkinson disease 7, autosomal recessive early-onset	6.8
28	parkinson disease 12	6.8
29	parkinson disease-16	6.8
30	parkinson disease, juvenile, type 2	6.8
31	parkinson disease 11	6.8
32	vps35-related parkinson disease	6.3
33	cholesterol	6.3
34	fbxo7-related parkinson disease	6.3
35	frontotemporal dementia	6.3
36	gaucher's disease	6.3
37	homocysteine	6.3
38	lateral sclerosis	6.3
39	lewy body dementia	6.3
40	parkinson disease 5	6.3
41	paralysis agitans, juvenile, of hunt	6.3
42	pathological gambling	6.3
43	tauopathy	5.4
44	alcoholism	5.4
45	torsion dystonia	5.4
46	amyotrophic lateral sclerosis	5.4
47	twinning	5.4
48	bell's palsy	5.4
49	wolff-parkinson-white syndrome	5.4
50	corticobasal degeneration	5.4

Clinical features from OMIM: 168601

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 amantadine, amantadine hydrochloride, benztropine, benztropine mesylate, biperiden, biperiden hydrochloride, biperiden lactate, bromocriptine, bromocriptine mesylate, cabergoline, carbidopa, entacapone, levodopa, pergolide, pergolide mesylate, pramipexole, pramipexole dihydrochloride, ropinirole, ropinirole hydrochloride, selegiline, selegiline hydrochloride, tolcapone, trihexyphenidyl, trihexyphenidyl hydrochloride

Articles related to parkinson disease 1:

id	Title	Authors	Year	Affiliating Genes
1	Expression of Cbl-interacting protein of 85 kDa in MPTP mouse model of Parkinson's disease and 1-methyl-4-phenyl-pyridinium ion-treated dopaminergic SH-SY5Y cells. (18535749)	Bian M.... Huang F.	2008	SH3KBP1

Genes related to parkinson disease 1 according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	SH3KBP1	SH3-domain kinase binding protein 1	11.0	Publications
2	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Disorders

Cellular components related to parkinson disease 1 according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	synapse	GO:045202	9.1	SNCA, SH3KBP1