Parkinson Disease 10 malady

MalaCards: Parkinson Disease 10 is related to parkinson's disease and dementia. An important gene associated with Parkinson Disease 10 is PARK10 (Parkinson disease 10 (susceptibility)), and among its related pathways are Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. The compounds 1 methyl 4 phenylpyridinium and mptp have been mentioned in the context of this disorder. Related mouse phenotypes are no phenotypic analysis and behavior/neurological.

parkinson disease 10 33 43

Disease types for parkinson's disease family:

parkinson disease type 3	parkinson disease type 9
parkinson disease 10	parkinson disease-16
parkinson disease 12	parkinson disease 11
parkinson disease 5	parkinson disease 4
parkinson disease 1	parkinson disease 14

Diseases related to parkinson disease 10 by text searches and GeneDecks gene sharing:

(show top 50)    (show all 79)

id	Related Disease	Score	Top Affiliating Genes
1	parkinson's disease	38.5	SNCA, PARK7
2	dementia	29.7	LRRK2, SNCA, PARK2, PARK7, PINK1
3	essential tremor	29.0	LRRK2, SNCA, PARK2
4	parkinson disease type 3	28.8	PARK7, PARK2, SNCA, LRRK2
5	alzheimer's disease	28.7	LRRK2, SNCA, PARK2, PARK7, PINK1
6	gaucher's disease	27.6	PARK2, SNCA
7	neurodegeneration	27.6	PINK1, PARK7, PARK2, SNCA, LRRK2
8	lewy body dementia	27.2	PARK2, SNCA, LRRK2
9	tremor	27.2	PINK1, PARK7, PARK2, SNCA, LRRK2
10	frontotemporal dementia	27.2	PARK2, SNCA, LRRK2
11	neuroblastoma	26.6	LRRK2, SNCA, PARK2, PARK7
12	lateral sclerosis	26.4	PARK7, PARK2, SNCA, LRRK2
13	tauopathy	25.2	LRRK2, SNCA, PARK2, PARK7
14	amyotrophic lateral sclerosis	25.1	LRRK2, SNCA, PARK2, PARK7
15	multiple sclerosis	25.1	SNCA, PARK2, PARK7, PINK1
16	cognitive disease	12.4	SNCA, PARK2
17	dysautonomia	12.4	PARK2, SNCA
18	spinocerebellar ataxia type 3	12.4	PARK2, SNCA
19	restless legs syndrome	12.3	SNCA, PARK2
20	gliosis	12.3	PARK2, SNCA
21	aphasia	12.3	SNCA, LRRK2
22	myoclonus	12.2	SNCA, PARK2
23	prion disease	12.1	PARK2, SNCA
24	inclusion body myositis	12.0	PARK7, PARK2, SNCA
25	myositis	12.0	PARK7, PARK2, SNCA
26	pick's disease	11.9	PARK7, SNCA
27	progressive supranuclear palsy	11.9	PARK2, SNCA, LRRK2
28	supranuclear palsy	11.4	PARK7, PARK2, SNCA, LRRK2
29	multiple system atrophy	11.4	LRRK2, SNCA, PARK2, PARK7
30	cerebritis	11.2	LRRK2, SNCA, PARK2, PARK7
31	movement disease	11.0	LRRK2, SNCA, PARK2, PARK7, PINK1
32	neurodegenerative disease	10.9	LRRK2, SNCA, PARK2, PARK7, PINK1
33	lrrk2-related parkinson disease	8.2
34	autosomal recessive juvenile parkinson disease	7.9
35	htra2-related parkinson disease	7.7
36	pink1 type of young-onset parkinson disease	7.7
37	neuronitis	7.5
38	parkin type of juvenile parkinson disease	7.5
39	park7-related parkinson disease	7.5
40	snca-related parkinson disease	7.5
41	parkinson disease type 9	7.2
42	parkinson disease 11	6.8
43	parkinson disease 15, autosomal recessive	6.8
44	parkinson disease 14	6.8
45	parkinson disease 4	6.8
46	parkinson disease 1	6.8
47	parkinson disease, resistance to	6.8
48	postencephalitic parkinson disease	6.8
49	secondary parkinson disease	6.8
50	parkinson disease multi-gene panels	6.8

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to parkinson disease 10:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	no phenotypic analysis	MP:0003012	8.0	PINK1, PARK2, SNCA, LRRK2
2	behavior/neurological phenotype	MP:0005386	7.6	LRRK2, SNCA, PARK2, PARK7, PINK1
3	homeostasis/metabolism phenotype	MP:0005376	7.5	PARK2, SNCA, PINK1, LRRK2, PARK7
4	nervous system phenotype	MP:0003631	7.4	PINK1, PARK7, PARK2, SNCA, LRRK2
5	cellular phenotype	MP:0005384	7.2	PINK1, PARK2, LRRK2, SNCA, PARK7

Articles related to parkinson disease 10:

id	Title	Authors	Year	Affiliating Genes
1	Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder. (17761553)	Klein C.... Schlossmacher M.G.	2007	SNCA, PARK7, PARK2

Genes related to parkinson disease 10 according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	PARK10	Parkinson disease 10 (susceptibility)	11.1	Aliases & Descriptions
2	PARK7	parkinson protein 7	11.0	Publications
3	PINK1	PTEN induced putative kinase 1	11.0	Publications
4	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Publications
5	LRRK2	leucine-rich repeat kinase 2	11.0	Publications
6	PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	11.0	Publications

Pathways related to parkinson disease 10 according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway41	9.3	PARK2, SNCA
2	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway10	9.0	PARK2, SNCA
3	Parkinsons Disease Pathway36	8.3	PARK7, PINK1, SNCA, PARK2
4	Parkinsons disease20	7.6	PINK1, LRRK2, SNCA, PARK2, PARK7
5	Neuroscience3	7.5	PINK1, PARK2, PARK7, SNCA, LRRK2

Compounds related to parkinson disease 10 according to GeneDecks:

(show all 12)

id	Compound	Score	Top Affiliating Genes
1	1 methyl 4 phenylpyridinium32	9.5	PARK2, SNCA
2	mptp32	9.4	SNCA, PARK2
3	geldanamycin32 9 9	11.3	PARK2, SNCA
4	catecholamine32	9.3	SNCA, PARK2
5	rotenone32	9.1	PARK2, PARK7, SNCA
6	6-hydroxydopamine32	9.1	PARK7, PARK2, SNCA
7	lactacystin32	9.0	SNCA, PARK2
8	methionine32	9.0	SNCA, PARK7, PINK1
9	lysine32	8.9	SNCA, PARK7, PARK2
10	h2o232	8.8	SNCA, PARK2, PARK7
11	levodopa32 9 9	9.8	PARK7, PINK1, LRRK2, SNCA, PARK2
12	dopamine32 9 18 9	10.8	PARK2, PARK7, PINK1, SNCA, LRRK2

Cellular components related to parkinson disease 10 according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrion	GO:005739	7.5	PINK1, PARK7, PARK2, SNCA, LRRK2

Biological processes related to parkinson disease 10 according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrion degradation	GO:000422	9.6	PINK1, PARK2
2	dopamine uptake involved in synaptic transmission	GO:051583	9.6	SNCA, PARK7
3	negative regulation of cell death	GO:060548	9.5	PARK7, PARK2
4	neuron death	GO:070997	9.3	PARK2, LRRK2
5	adult locomotory behavior	GO:008344	9.3	SNCA, PARK7
6	regulation of locomotion	GO:040012	9.2	LRRK2, SNCA
7	peptidyl-serine phosphorylation	GO:018105	9.1	LRRK2, PINK1
8	cell death	GO:008219	9.0	PARK7, PARK2, PINK1
9	negative regulation of neuron apoptotic process	GO:043524	9.0	SNCA, PARK2, PARK7
10	autophagy	GO:006914	8.9	PARK7, LRRK2