Parkinson Disease 4 malady

MalaCards: Parkinson Disease 4, also known as parkinson disease, is related to dementia and alzheimer's disease. An important gene associated with Parkinson Disease 4 is SNCA (synuclein, alpha (non A4 component of amyloid precursor)). The drugs bromocriptine and pergolide have been mentioned in the context of this disorder.

OMIM: 605543

parkinson disease 4 33 parkinson disease 43

Disease types for parkinson's disease family:

parkinson disease type 3	parkinson disease type 9
parkinson disease 10	parkinson disease-16
parkinson disease 12	parkinson disease 11
parkinson disease 5	parkinson disease 4
parkinson disease 1	parkinson disease 14

Diseases related to parkinson disease 4 by text searches and GeneDecks gene sharing:

(show top 50)    (show all 52)

id	Related Disease	Score	Top Affiliating Genes
1	dementia	8.9
2	alzheimer's disease	8.4
3	lrrk2-related parkinson disease	8.2
4	autosomal recessive juvenile parkinson disease	7.9
5	htra2-related parkinson disease	7.7
6	pink1 type of young-onset parkinson disease	7.7
7	parkinson disease type 3	7.7
8	parkin type of juvenile parkinson disease	7.5
9	park7-related parkinson disease	7.5
10	snca-related parkinson disease	7.5
11	essential tremor	7.5
12	parkinson disease type 9	7.2
13	parkinson disease 10	7.2
14	tremor	7.2
15	parkinson disease 14	6.8
16	parkinson disease 1	6.8
17	parkinson disease, resistance to	6.8
18	postencephalitic parkinson disease	6.8
19	secondary parkinson disease	6.8
20	neuroblastoma	6.8
21	parkinson disease multi-gene panels	6.8
22	parkinson disease 6, early onset	6.8
23	parkinson disease 7, autosomal recessive early-onset	6.8
24	parkinson disease 12	6.8
25	parkinson disease-16	6.8
26	parkinson disease, juvenile, type 2	6.8
27	parkinson disease 11	6.8
28	parkinson disease 15, autosomal recessive	6.8
29	cholesterol	6.3
30	fbxo7-related parkinson disease	6.3
31	frontotemporal dementia	6.3
32	gaucher's disease	6.3
33	homocysteine	6.3
34	lateral sclerosis	6.3
35	lewy body dementia	6.3
36	parkinson disease 5	6.3
37	paralysis agitans, juvenile, of hunt	6.3
38	pathological gambling	6.3
39	vps35-related parkinson disease	6.3
40	torsion dystonia	5.4
41	amyotrophic lateral sclerosis	5.4
42	bell's palsy	5.4
43	wolff-parkinson-white syndrome	5.4
44	corticobasal degeneration	5.4
45	dysphagia	5.4
46	lung cancer	5.4
47	melanoma	5.4
48	oculopharyngeal muscular dystrophy	5.4
49	pallidopyramidal syndrome	5.4
50	prolidase deficiency	5.4

Clinical features from OMIM: 605543

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 amantadine, amantadine hydrochloride, benztropine, benztropine mesylate, biperiden, biperiden hydrochloride, biperiden lactate, bromocriptine, bromocriptine mesylate, cabergoline, carbidopa, entacapone, levodopa, pergolide, pergolide mesylate, pramipexole, pramipexole dihydrochloride, ropinirole, ropinirole hydrochloride, selegiline, selegiline hydrochloride, tolcapone, trihexyphenidyl, trihexyphenidyl hydrochloride

Genes related to parkinson disease 4 according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Disorders